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deep thrombosis occult

Joachim Mikkelsen, Steen Henrik Matzen
INTRODUCTION: Cancer is a recognized risk factor of venous thromboembolism (VTE) as it induces a prothrombotic state through various mechanisms of activation of coagulation. Recognizing occult cancer as a risk factor is equally important. In patients with no known thromboembolic risk factors, utilizing PET/CT as a screening tool may be considered in order to reveal occult malignancy associated with otherwise unexplainable VTE. METHODS: This case report has been reported in line with the SCARE criteria...
October 14, 2016: International Journal of Surgery Case Reports
Karen N Zaghiyan, Harry C Sax, Emily Miraflor, David Cossman, Willis Wagner, James Mirocha, Bruce Gewertz, Phillip Fleshner
OBJECTIVE: To identify the optimal timing of perioperative chemical thromboprophylaxis (CTP) and incidence of occult preoperative deep vein thrombosis (OP-DVT) in patients undergoing major colorectal surgery. BACKGROUND: There is limited Level 1 data regarding the optimal timing of CTP in major colorectal surgery and the incidence of OP-DVT remains unclear. Both issues influence the occurrence of venous thromboembolism (VTE) and may impact Medicare reimbursement because of penalties for hospital-acquired conditions...
October 2016: Annals of Surgery
Prajwal Dhakal, Krishna Gundabolu, Vijaya R Bhatt
Venous thromboembolism (VTE) is associated with significant morbidity and mortality. Factors such as the presence of transient risk factors for VTE, risk of bleeding, and location of deep vein thrombosis (DVT) determine the duration of anticoagulation. Extended anticoagulation is offered to patients with unprovoked pulmonary embolism (PE) or proximal DVT and a low risk of bleeding. Anticoagulation for 3 months is advised in patients with provoked DVT or PE, high risk of bleeding, and isolated distal or upper extremity DVT...
June 5, 2016: Clinical and Applied Thrombosis/hemostasis
Amgad Said, Justin Keasberry
BACKGROUND: Venous gangrene complicating deep vein thrombosis in the context of anticoagulation use in patients with gynecologic malignancy is rarely reported. We report an unusual presentation of venous gangrene of the lower limbs associated with warfarin therapy in a 53-year-old woman from the Cook Islands with an occult ovarian cancer. CASE PRESENTATION: A 53-year-old woman of Cook Islands origin presented with exertional dyspnea, rapid atrial fibrillation, bilateral lower limb edema, and painful digital ischemia of her hallux...
2016: Journal of Medical Case Reports
Andrew S Griffin, Matthew D Crawford, Rajan T Gupta
Gas gangrene is a rare but often fatal soft-tissue infection. Because it is uncommon and the classic symptom of crepitus does not appear until the infection is advanced, prompt diagnosis requires a high index of suspicion. We present a case report of a middle-aged man who presented with acute onset lower-extremity pain that was initially thought to be due to deep vein thrombosis. After undergoing workup for pulmonary embolism, he was found to have massive gas gangrene of the lower extremity secondary to an occult colon adenocarcinoma and died within hours of presentation from multisystem organ failure...
June 2016: Radiology case reports
T I Hussain, J A Stephenson, B Das, S Naqvi, R Verma, D Barnes
AIM: To investigate and review the diagnostic yield for occult malignancy in patients who underwent abdominopelvic computed tomography (CT) after the diagnosis of unprovoked venous thromboembolism (VTE) with reference to the guidelines set by The National Institute for Health and Clinical Excellence (NICE). MATERIALS AND METHODS: We retrospectively reviewed all unprovoked VTE diagnosed within a large teaching hospital over a period of 21 months for subsequent imaging investigations and cancer diagnoses...
October 2016: Clinical Radiology
M Berrah-Bennaceur, A Berrah, M Arrada
INTRODUCTION: Venous thromboembolism (VTE) and cancer is an association with increasing progression and poor prognosis. It always raises many issues including the question what is the exact incidence of occult cancer in a VTE? Is there a simple biological marker with a predictive value of this combination? Can we define a strategy thromboprophylaxis in cancer patients? AIM: To try to answer these questions we conducted a prospective study. MATERIALS AND METHODS: We collected 140 patients with VTE, 70 of neoplastic origin ( group A) and 70 of other etiologies (Group B)...
April 2016: Thrombosis Research
Donghee Han, Bríain ó Hartaigh, Ji Hyun Lee, In-Jeong Cho, Chi Young Shim, Hyuk-Jae Chang, Geu-Ru Hong, Jong-Won Ha, Namsik Chung
BACKGROUND: Unprovoked venous thromboembolism (VTE) is related to a higher incidence of occult cancer. D-dimer is clinically used for screening VTE, and has often been shown to be present in patients with malignancy. We explored the predictive value of D-dimer for detecting occult cancer in patients with unprovoked VTE. METHODS: We retrospectively examined data from 824 patients diagnosed with deep vein thrombosis or pulmonary thromboembolism. Of these, 169 (20...
2016: PloS One
Milan Jovanović, Natasa Janjusević, Darko Mirković, Maja Vulović, Bosko Milev, Miroslav Mitrović, Bratislav Trifunović
INTRODUCTION: Primary extragonadal seminomas are rare tumors. There have been only a few cases of the primary retroperitoneal seminomas reported in the literature up to date. CASE REPORT: We reported a 56-year-old man with giant primary retroperitoneal seminoma presented with the enlargement of the left side of the abdomen and deep venous thrombosis of the left leg. Computed tomography of the abdomen showed a large tumor occupying the left part of the retroperitoneal space with 23 x 13 cm in diameter...
February 2016: Vojnosanitetski Pregled. Military-medical and Pharmaceutical Review
Hongwei Shen, Jianhong Shang, Gang Niu, Jun Liu, Zeshan You, Shanyang He
Ovarian cancer associated with deep venous thrombosis (DVT) is an uncommon, potentially life-threatening condition. The primary therapeutic strategy for the treatment of this condition is up-front primary cytoreductive surgery, with placement of an inferior vena cava (IVC) filter prior to surgery to prevent fatal pulmonary embolism. The present study describes the case of a 49-year-old female, who presented with DVT unresponsive to anticoagulant therapy in the lower extremities prior to the diagnosis of ovarian cancer...
October 2015: Oncology Letters
Jonathan Montomoli, Rune Erichsen, Kirstine Kobberøe Søgaard, Dóra Körmendiné Farkas, Anna-Marie Bloch Münster, Henrik Toft Sørensen
OBJECTIVE: Venous thromboembolism (VTE) may be a marker of occult cancer in the general population. While liver disease is known to increase the risk of VTE and cancer, it is unclear whether VTE in patients with liver disease is also a marker of occult cancer. DESIGN: A population-based cohort study. SETTING: Denmark. PARTICIPANTS: We used population-based health registries to identify all patients with liver disease in Denmark with a first-time diagnosis of VTE (including superficial or deep venous thrombosis and pulmonary embolism) during 1980-2010...
2015: BMJ Open Gastroenterology
John A Harris, Carolyn W Swenson, Shitanshu Uppal, Neil Kamdar, Nichole Mahnert, Sawsan As-Sanie, Daniel M Morgan
BACKGROUND: In April 2014, the US Food and Drug Administration (FDA) published its first safety communication discouraging "the use of laparoscopic power morcellation during hysterectomy or myomectomy for the treatment of women with uterine fibroids." Due to the concern of worsening outcomes for patients with occult uterine malignancy, specifically uterine leiomyosarcoma, the FDA recommended a significant change to existing surgical planning, patient consent, and surgical technique in the United States...
January 2016: American Journal of Obstetrics and Gynecology
Julio Jiménez-Bonilla, Remedios Quirce, Ignacio Banzo, Isabel Martínez-Rodríguez, José Manuel Carril
In a 73-year-old man, an occult neoplasm was suspected after 2 consecutive deep venous thrombosis, the latter under anticoagulant therapy and previous axonopathy. After normal CT and MRI findings, a requested (18)F-FDG PET/CT showed a focal uptake in the prostate. Because FDG uptake in the prostate is infrequent, a (11)C-choline PET/CT was indicated revealing a focal uptake in the same location. No other abnormalities were detected in the rest of the body. A guided biopsy by ultrasonography was performed revealing a prostate carcinoma and inflammation in both prostatic lobes...
August 2015: Clinical Nuclear Medicine
Christopher P Michetti, Elizabeth Franco, Jonathan Coleman, Anna Bradford, Amber W Trickey
BACKGROUND: Trauma patients requiring acute inpatient rehabilitation are significantly injured, with increased risk for deep vein thrombosis (DVT). We evaluated routine screening for occult DVT in such patients, and analyzed DVT risk factors. MATERIALS AND METHODS: Data from level I trauma center patients discharged to a single acute rehabilitation center (ARC) from 2007-2011 were retrospectively reviewed. Routine lower extremity duplex was performed on ARC admission...
December 2015: Journal of Surgical Research
Cliona C Kirwan, C N McCollum, G McDowell, G J Byrne
UNLABELLED: Venous thromboembolism (VTE) during chemotherapy is common, with 7% mortality in metastatic breast cancer (MBC). In a prospective cohort study of patients with breast cancer, we investigated whether vascular endothelial cell activation (VECA), and whether apoptosis, is the cause of chemotherapy-induced VTE. METHODS: Serum markers of VECA, E-selectin (E-sel), vascular cell adhesion molecule 1 (VCAM-1) and d-dimer (fibrin degradation and hypercoagulability marker) were measured prechemotherapy and at 1, 4, and 8 days following chemotherapy...
July 2015: Clinical and Applied Thrombosis/hemostasis
Kelly Welker, Shimoni Dharia
Pleural Student/Resident Case Report PostersSESSION TYPE: Medical Student/Resident Case ReportPRESENTED ON: Tuesday, October 28, 2014 at 01:30 PM - 02:30 PMINTRODUCTION: Spontaneous chylothorax is a rare cause of pleural effusions outside of the neonatal period. A case of traumatic chylothorax and spinal contusion in a toddler is described without any overt signs of injury.CASE PRESENTATION: A healthy fifteen month female presented to the emergency room with inability to bear weight. Earlier that day, she played in a bounce house and upon returning home she could not ambulate...
October 1, 2014: Chest
M Czihal, J Röling, A Rademacher, A Schröttle, P Kuhlencordt, U Hoffmann
OBJECTIVES: To evaluate the clinical presentation and disease course of symptomatic plantar vein thrombosis. PATIENTS AND METHODS: Patients with a first diagnosis of symptomatic plantar vein thrombosis at our institution were retrospectively identified from a prospectively maintained database. All patients underwent complete venous compression sonography extended to the plantar veins because of local symptoms at the sole of the foot. Clinical characteristics were obtained from the medical records...
December 2015: Phlebology
Sameer A Patel, Hamid Abdollahi, John A Ridge, Eric I Chang, Miriam N Lango, Neal S Topham
The free fibula flap is the preferred reconstructive method for oncologic defects of the mandible. Arterial inflow of the extremity is routinely evaluated with several modalities; however, venous screening is rarely performed. Patients with cancer are at elevated risk of occult deep venous thrombosis (DVT). An asymptomatic thrombus encountered during free fibula reconstruction is a serious concern. Although such cases have been reported, we suspect the incidence of DVT during fibula free flap harvest is underappreciated...
April 2016: Annals of Plastic Surgery
Takashi Ueda, Kenichi Tanabe, Miho Morita, Chihoko Nakahara, Kensei Katsuoka
A 66-year-old woman with a history of deep vein thrombosis (DVT) presented with an irregularly shaped leg ulcer surrounded by pigmentation on the left lower limb. In addition, the circumference of her left thigh had gradually increased. The ulcer did not respond to topical treatment and enlarged, therefore, she visited our hospital. Arteriography of the left lower limb showed multiple arteriovenous malformations (AVMs), based on which we made a diagnosis of a leg ulcer due to multiple AVMs. Transcatheter arterial embolisation with a mixture of N-butyl-2-cyanoacrylate and lipiodol was performed six times in the period of about a year for treating the AVMs...
April 2016: International Wound Journal
Peter Y M Woo, Danny T M Chan, Tom C Y Cheung, X L Zhu, W S Poon
Trousseau's syndrome is defined as any unexplained thrombotic event that precedes the diagnosis of an occult visceral malignancy or appears concomitantly with a tumour. This report describes a young, previously healthy man diagnosed to have an acute middle cerebral arterial ischaemic stroke and lower-limb deep vein thrombosis, who subsequently succumbed to pulmonary arterial embolism. During the course of his illness, he was diagnosed to have a malignant pleural effusion secondary to an occult adenocarcinoma...
February 2014: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
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