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https://www.readbyqxmd.com/read/28741800/eteplirsen-for-the-treatment-of-duchenne-muscular-dystrophy-quality-of-evidence-concerns-an-alternative-viewpoint
#1
Adriane N Irwin, Megan C Herink
We read the paper by Reinig AM and colleagues entitled "Advances in the Treatment of Duchenne Muscular Dystrophy: New and Emerging Pharmacotherapies" with great interest.(1) The authors discuss several novel therapies to increase production of dystrophin in myocytes, of which, eteplirsen (Exondys) is the only currently approved by the US Food & Drug Administration (FDA).(2) Pharmacologic management of Duchenne muscular dystrophy (DMD) centers on the use of glucocorticoids which works by decreasing inflammation and reducing immune system activity...
July 25, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/28728059/iterative-variational-mode-decomposition-based-automated-detection-of-glaucoma-using-fundus-images
#2
Shishir Maheshwari, Ram Bilas Pachori, Vivek Kanhangad, Sulatha V Bhandary, U Rajendra Acharya
Glaucoma is one of the leading causes of permanent vision loss. It is an ocular disorder caused by increased fluid pressure within the eye. The clinical methods available for the diagnosis of glaucoma require skilled supervision. They are manual, time consuming, and out of reach of common people. Hence, there is a need for an automated glaucoma diagnosis system for mass screening. In this paper, we present a novel method for an automated diagnosis of glaucoma using digital fundus images. Variational mode decomposition (VMD) method is used in an iterative manner for image decomposition...
June 19, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28723916/stakeholders-views-and-experiences-of-care-and-interventions-for-addressing-frailty-and-pre-frailty-a-meta-synthesis-of-qualitative-evidence
#3
Barbara D'Avanzo, Rachel Shaw, Silvia Riva, Joao Apostolo, Elzbieta Bobrowicz-Campos, Donata Kurpas, Maria Bujnowska, Carol Holland
Frailty is a common condition in older age and is a public health concern which requires integrated care and involves different stakeholders. This meta-synthesis focuses on experiences, understanding, and attitudes towards screening, care, intervention and prevention for frailty across frail and healthy older persons, caregivers, health and social care practitioners. Studies published since 2001 were identified through search of electronic databases; 81 eligible papers were identified and read in full, and 45 papers were finally included and synthesized...
2017: PloS One
https://www.readbyqxmd.com/read/28719766/energy-expenditure-of-standing-compared-to-sitting-while-conducting-office-tasks
#4
Jill Burns, Cuisle Forde, Sara Dockrell
Objectives This study aimed to investigate the energy expenditure of common office-based tasks. The objectives were to: (a) test the classification of tasks as sedentary or light-intensity physical activity and (b) compare the energy expenditure of tasks under two postural conditions (sitting and standing). Background The sedentary nature of office work has been highlighted as a health risk, and strategies to reduce sedentary behavior at work have been developed. However, there is limited evidence to guide the utilization of sit-stand workstations in the workplace for metabolic health benefits...
July 1, 2017: Human Factors
https://www.readbyqxmd.com/read/28699568/evaluation-of-the-informatician-perspective-determining-types-of-research-papers-preferred-by-clinicians
#5
Boshu Ru, Xiaoyan Wang, Lixia Yao
BACKGROUND: To deliver evidence-based medicine, clinicians often reference resources that are useful to their respective medical practices. Owing to their busy schedules, however, clinicians typically find it challenging to locate these relevant resources out of the rapidly growing number of journals and articles currently being published. The literature-recommender system may provide a possible solution to this issue if the individual needs of clinicians can be identified and applied...
July 5, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28696841/international-multi-site-survey-on-the-use-of-online-support-groups-in-bipolar-disorder
#6
Rita Bauer, Jörn Conell, Tasha Glenn, Martin Alda, Raffaella Ardau, Bernhard T Baune, Michael Berk, Yuly Bersudsky, Amy Bilderbeck, Alberto Bocchetta, Letizia Bossini, Angela M Paredes Castro, Eric Y W Cheung, Caterina Chillotti, Sabine Choppin, Maria Del Zompo, Rodrigo Dias, Seetal Dodd, Anne Duffy, Bruno Etain, Andrea Fagiolini, Miryam Fernández Hernandez, Julie Garnham, John Geddes, Jonas Gildebro, Ana Gonzalez-Pinto, Guy M Goodwin, Paul Grof, Hirohiko Harima, Stefanie Hassel, Chantal Henry, Diego Hidalgo-Mazzei, Vaisnvy Kapur, Girish Kunigiri, Beny Lafer, Erik R Larsen, Ute Lewitzka, Rasmus W Licht, Anne Hvenegaard Lund, Blazej Misiak, Patryk Piotrowski, Scott Monteith, Rodrigo Munoz, Takako Nakanotani, René E Nielsen, Claire O'donovan, Yasushi Okamura, Yamima Osher, Andreas Reif, Philipp Ritter, Janusz K Rybakowski, Kemal Sagduyu, Brett Sawchuk, Elon Schwartz, Ângela M Scippa, Claire Slaney, Ahmad H Sulaiman, Kirsi Suominen, Aleksandra Suwalska, Peter Tam, Yoshitaka Tatebayashi, Leonardo Tondo, Eduard Vieta, Maj Vinberg, Biju Viswanath, Julia Volkert, Mark Zetin, Peter C Whybrow, Michael Bauer
BACKGROUND: Peer support is an established component of recovery from bipolar disorder, and online support groups may offer opportunities to expand the use of peer support at the patient's convenience. Prior research in bipolar disorder has reported value from online support groups. AIMS: To understand the use of online support groups by patients with bipolar disorder as part of a larger project about information seeking. METHODS: The results are based on a one-time, paper-based anonymous survey about information seeking by patients with bipolar disorder, which was translated into 12 languages...
July 11, 2017: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/28673253/an-improved-filtering-algorithm-for-big-read-datasets-and-its-application-to-single-cell-assembly
#7
Axel Wedemeyer, Lasse Kliemann, Anand Srivastav, Christian Schielke, Thorsten B Reusch, Philip Rosenstiel
BACKGROUND: For single-cell or metagenomic sequencing projects, it is necessary to sequence with a very high mean coverage in order to make sure that all parts of the sample DNA get covered by the reads produced. This leads to huge datasets with lots of redundant data. A filtering of this data prior to assembly is advisable. Brown et al. (2012) presented the algorithm Diginorm for this purpose, which filters reads based on the abundance of their k-mers. METHODS: We present Bignorm, a faster and quality-conscious read filtering algorithm...
July 3, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28657899/a-descriptive-cross-sectional-survey-of-turkish-nurses-knowledge-of-pressure-ulcer-risk-prevention-and-staging
#8
Asiye Gul, Isil Isik Andsoy, Birgul Ozkaya, Ayten Zeydan
Nurses' knowledge of pressure ulcer (PU) prevention and management is an important first step in the provision of optimal care. To evaluate PU prevention/risk, staging, and wound description knowledge, a descriptive, cross-sectional survey was conducted among nurses working in an acute care Turkish hospital. The survey instrument was a modified and translated version of the Pieper Pressure Ulcer Knowledge Test (PUKT), and its validity and reliability were established. Nurses completed a Personal Characteristics Form, including sociodemographic information and exposure to educational presentations and information about and experience with PUs, followed by the 49-item modified PUKT which includes 33 prevention/risk items, 9 staging items, and 7 wound description items...
June 2017: Ostomy/wound Management
https://www.readbyqxmd.com/read/28639384/nurses-attitudes-towards-older-people-care-an-integrative-review
#9
REVIEW
Kathy L Rush, Stormee Hickey, Sheila Epp, Robert Janke
AIMS/OBJECTIVES: To examine hospital nurses' attitudes towards caring for older adults and delineate associated factors contributing to their attitudes. BACKGROUND: Population aging is of international significance. A nursing workforce able to care for the ageing population is critical for ensuring quality older adult care. A synthesis of research related to nurses' attitudes towards older adult care is important for informing care quality and the nursing workforce issues...
June 21, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28635439/social-and-occupational-factors-associated-with-psychological-wellbeing-among-occupational-groups-affected-by-disaster-a-systematic-review
#10
Samantha K Brooks, Rebecca Dunn, Richard Amlôt, G James Rubin, Neil Greenberg
BACKGROUND: The psychological impact of disasters has been well-documented; less attention has been paid to factors affecting the wellbeing of those exposed to disasters as occupational groups. AIMS: To conduct a systematic literature review identifying social and occupational factors affecting the wellbeing of disaster-exposed employees; to use these factors to identify recommendations for potential interventions. METHOD: Four electronic literature databases were searched; reference lists of relevant papers were hand-searched...
March 1, 2017: Journal of Mental Health
https://www.readbyqxmd.com/read/28633460/guidelines-for-composing-and-assessing-a-paper-on-treatment-of-pain
#11
Nikolai Bogduk, David J Kennedy, Yakov Vorobeychik, Andrew Engel
Authors, readers, and editors share a common focus. Authors want to publish their work. Readers want to see high-quality, new information. Referees and editors serve to ensure that authors provide valid conclusions based on the quality of information that readers want. Common to each of these roles are instructions to authors. However, these are typically written in an uninspiring, legalistic style, as if they are a set of rules that authors must obey if they expect to get published. This renders the instructions boring and oppressive, if not forbidding...
June 17, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28612998/symptom-experience-in-non-dialysis-dependent-chronic-kidney-disease-a-qualitative-descriptive-study
#12
Karen Pugh-Clarke, Sue Cheryl Read, Julius Sim
BACKGROUND: Studies indicate that symptoms attributable to impaired kidney function are important determinants of quality of life and functional status in patients with chronic kidney disease (CKD). Accordingly, symptom assessment and subsequent control are prerequisites of high-quality care in this patient population. Whilst symptom burden in patients with advanced CKD managed without dialysis has been likened to that of palliative care cancer populations, there is little information about the nature and range of symptoms in earlier stages of the CKD trajectory...
June 14, 2017: Journal of Renal Care
https://www.readbyqxmd.com/read/28594591/30-years-of-translational-research-in-zirconia-dental-implants-a-systematic-review-of-the-literature
#13
Allauddin Siddiqi, Abdul Samad Khan, Sobia Zafar
Thirty years of transitional research in zirconia (Zr) ceramics has led significant improvements in the biomedical field especially in dental Implantology. Oral implants made of Yttria-tetragonal zirconia polycrystals (Y-TZP) because of their excellent mechanical properties, good biocompatibility and aesthetically acceptable colour have emerged as an attractive metal-free alternative to titanium implants. The aim of the review was to highlight the translation research in Zr dental implants that has been conducted over the last three decades using pre-clinical animal models...
June 8, 2017: Journal of Oral Implantology
https://www.readbyqxmd.com/read/28593606/gazepath-an-eye-tracking-analysis-tool-that-accounts-for-individual-differences-and-data-quality
#14
Daan R van Renswoude, Maartje E J Raijmakers, Arnout Koornneef, Scott P Johnson, Sabine Hunnius, Ingmar Visser
Eye-trackers are a popular tool for studying cognitive, emotional, and attentional processes in different populations (e.g., clinical and typically developing) and participants of all ages, ranging from infants to the elderly. This broad range of processes and populations implies that there are many inter- and intra-individual differences that need to be taken into account when analyzing eye-tracking data. Standard parsing algorithms supplied by the eye-tracker manufacturers are typically optimized for adults and do not account for these individual differences...
June 7, 2017: Behavior Research Methods
https://www.readbyqxmd.com/read/28570245/a-descriptive-study-to-explore-the-effect-of-peristomal-skin-complications-on-quality-of-life-of-adults-with-a-permanent-ostomy
#15
Diane Maydick-Youngberg
Approximately 1 million people are living with an ostomy, and 100 000 to 130 000 new ostomies are created each year. The exact incidence and prevalence of complications are unknown but have been reported to be as high as 70% and to affect quality of life (QoL). Using convenience sampling methods, a descriptive study was conducted to explore QoL scores and peristomal complications reported by adults with a permanent ostomy attending the 2009 United Ostomy Associations of America conference. Attendees who had a permanent ileostomy, colostomy, or urostomy; were at least 18 years of age; and able to read and speak English were invited to participate...
May 2017: Ostomy/wound Management
https://www.readbyqxmd.com/read/28503123/thromboelastometry-and-thrombelastography-analysis-under-normal-physiological-conditions-systematic-review
#16
Marcel Adler, Sandra Ivic, Nicolas S Bodmer, Hugo Ten Cate, Lucas M Bachmann, Walter A Wuillemin, Michael Nagler
BACKGROUND: Studies investigating thromboelastometry or thrombelastography analyses in a physiological context are scattered and not easy to access. OBJECTIVE: To systematically retrieve and describe published reports studying healthy subjects and targeting at the correlation of ROTEM® and TEG® measurements with conventional parameters of hemostasis. METHODS: Systematic Review: Papers were searched in Medline, Scopus and the Science Citation Index database...
April 2017: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/28499931/empowered-to-cook-the-crucial-role-of-food-agency-in-making-meals
#17
Amy B Trubek, Maria Carabello, Caitlin Morgan, Jacob Lahne
What makes an individual, on any given occasion, able and willing to prepare a meal for themselves: that is, to cook? As home cooking has increasingly become the focus of public-health, nutrition, and policy interventions and campaigns, the need for a better understanding has become apparent. It is clear that cooking is not merely a matter of mechanical skill or rote training; beyond this, it is difficult to explain why similar individuals have such different capacities for setting and achieving food-related goals...
May 9, 2017: Appetite
https://www.readbyqxmd.com/read/28474435/a-review-of-the-oral-health-related-quality-of-life-ohrql-model-for-dental-hygiene-eighteen-years-later
#18
C C Gadbury-Amyot, K S Austin, M Simmer-Beck
PURPOSE: The purpose of this paper is to review available evidence to determine the impact of the oral health-related quality of life (OHRQL) Model for Dental Hygiene on education, research, and practice. METHODS: A search was conducted in PubMed using the search terms oral health-related quality of life, OHRQL, and dental hygiene and limited to publications between 1998 and 2016. Google Scholar was also used to identify citations for the two original OHRQL model papers to capture the literature widely read by practicing dental hygienists but not indexed in PubMed...
May 5, 2017: International Journal of Dental Hygiene
https://www.readbyqxmd.com/read/28468166/etiology-of-nasal-bone-fractures
#19
Kun Hwang, So Jung Ki, Sang Hyun Ko
The aim of this study was to perform a systematic review of the etiology of nasal bone fractures (NBFs).In PubMed (500 titles) and Scopus (272), the search terms "nasal bone fracture" AND "etiology OR cause" were used. Among the 772 titles, 137 were duplicated and excluded. The 552 titles were excluded and 83 abstracts were read. Subsequently, 42 abstracts were excluded and 41 full articles providing data on etiologies of NBFs were reviewed. Finally, 26 papers were incorporated into this analysis.The causes of NBFs were different between adults and children...
May 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28468023/islamic-civilization-in-spain-a-magnificient-example-of-interaction-and-unity-of-religion-and-science
#20
Safvet Halilović
Islam and its followers had created a civilization that played very important role on the world stage for more than a thousand years. One of the most important specific qualities of the Islamic civilization is that it is a well-balanced civilization that brought together science and faith, struck a balance between spirit and matter and did not separate this world from the Hereafter. This is what distinguishes the Islamic civilization from other civilizations which attach primary importance to the material aspect of life, physical needs and human instincts, and attach greater attention to this world by striving to instantly satisfy desires of the flesh, without finding a proper place for God and the Hereafter in their philosophies and education systems...
April 2017: Psychiatria Danubina
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