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https://www.readbyqxmd.com/read/29785401/rheumatoid-arthritis-and-mirnas-a-critical-review-through-a-functional-view
#1
REVIEW
Maria Cristina Moran-Moguel, Stefania Petarra-Del Rio, Evangelina E Mayorquin-Galvan, Maria G Zavala-Cerna
Rheumatoid arthritis (RA) is a systemic autoimmune disease with severe joint inflammation and destruction associated with an inflammatory environment. The etiology behind RA remains to be elucidated; most updated concepts include the participation of environmental, proteomic, epigenetic, and genetic factors. Epigenetic is considered the missing link to explain genetic diversification among RA patients. Within epigenetic factors participating in RA, miRNAs are defined as small noncoding molecules with a length of approximately 22 nucleotides, capable of gene expression modulation, either negatively through inhibition of translation and degradation of the mRNA or positively through increasing the translation rate...
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/29782993/generalized-recurrent-neural-network-accommodating-dynamic-causal-modeling-for-functional-mri-analysis
#2
Yuan Wang, Yao Wang, Yvonne W Lui
Dynamic Causal Modeling (DCM) is an advanced biophysical model which explicitly describes the entire process from experimental stimuli to functional magnetic resonance imaging (fMRI) signals via neural activity and cerebral hemodynamics. To conduct a DCM study, one needs to represent the experimental stimuli as a compact vector-valued function of time, which is hard in complex tasks such as book reading and natural movie watching. Deep learning provides the state-of-the-art signal representation solution, encoding complex signals into compact dense vectors while preserving the essence of the original signals...
May 18, 2018: NeuroImage
https://www.readbyqxmd.com/read/29759953/acceptability-of-a-mobile-phone-app-for-measuring-time-use-in-breast-cancer-survivors-life-in-a-day-mixed-methods-study
#3
Matthew Cole Ainsworth, Dori Pekmezi, Heather Bowles, Diane Ehlers, Edward McAuley, Kerry S Courneya, Laura Q Rogers
BACKGROUND: Advancements in mobile technology allow innovative data collection techniques such as measuring time use (ie, how individuals structure their time) for the purpose of improving health behavior change interventions. OBJECTIVE: The aim of this study was to examine the acceptability of a 5-day trial of the Life in a Day mobile phone app measuring time use in breast cancer survivors to advance technology-based measurement of time use. METHODS: Acceptability data were collected from participants (N=40; 100% response rate) using a self-administered survey after 5 days of Life in a Day use...
May 14, 2018: JMIR Cancer
https://www.readbyqxmd.com/read/29746695/finding-the-forgotten-motivating-military-veterans-to-register-with-a-primary-healthcare-practice
#4
Alan Finnegan, Robin Jackson, Robin Simpson
Introduction: In the UK, primary healthcare practices choose from a series of Read codes to detail certain characteristics onto a patient's medical documentation. One of these codes is for military veterans indicating a history relating to military service. However, veterans are poor at seeking help, with research indicating that this code is only applied in 7.9% of cases. Clinical staff have a clear role in motivating veterans to declare their ex-Forces status or register with a primary healthcare center...
May 9, 2018: Military Medicine
https://www.readbyqxmd.com/read/29702601/trusted-operations-on-sensor-data-%C3%A2
#5
Hassaan Janjua, Wouter Joosen, Sam Michiels, Danny Hughes
The widespread use of mobile devices has allowed the development of participatory sensing systems that capture various types of data using the existing or external sensors attached to mobile devices. Gathering data from such anonymous sources requires a mechanism to establish the integrity of sensor readings. In many cases, sensor data need to be preprocessed on the device itself before being uploaded to the target server while ensuring the chain of trust from capture to the delivery of the data. This can be achieved by a framework that provides a means to implement arbitrary operations to be performed on trusted sensor data, while guaranteeing the security and integrity of the data...
April 27, 2018: Sensors
https://www.readbyqxmd.com/read/29698001/initial-development-of-the-recovery-oriented-services-assessment-a-collaboration-with-peer-provider-consultants
#6
Amy C Lodge, Wendy Kuhn, Juli Earley, Stacey Stevens Manser
OBJECTIVE: The Recovery Self-Assessment (RSA) is a reliable and valid tool used to measure recovery-oriented services. Recent studies, however, suggest that the length and reading level of the RSA makes its routine use in service settings difficult. Recognizing the importance of including people with lived experience of a mental health challenge in research processes and the need to enhance the utility of tools that measure recovery-oriented services, this paper describes an innovative researcher-peer provider consultant multistep process used to revise the provider version of the RSA to create a new instrument-the Recovery-Oriented Services Assessment (ROSA)...
April 26, 2018: Psychiatric Rehabilitation Journal
https://www.readbyqxmd.com/read/29689052/full-disclosure-genome-assembly-is-still-hard
#7
Stephen Richards
Two recent papers highlight the fascinating comparative genomics of anhydrobiosis, the ability to withstand complete desiccation, in bdelloid rotifers and tardigrades. However, both groups had to openly deal with the significant difficulties of generating and interpreting short-read draft assemblies-especially challenging in microscopic species with high sequence polymorphism. These exemplars demonstrate the need to go beyond single draft-quality reference genomes to high-quality multiple species comparative genomics if we are to fully capture the value of genomics...
April 2018: PLoS Biology
https://www.readbyqxmd.com/read/29685871/sentiment-analysis-of-health-care-tweets-review-of-the-methods-used
#8
REVIEW
Sunir Gohil, Sabine Vuik, Ara Darzi
BACKGROUND: Twitter is a microblogging service where users can send and read short 140-character messages called "tweets." There are several unstructured, free-text tweets relating to health care being shared on Twitter, which is becoming a popular area for health care research. Sentiment is a metric commonly used to investigate the positive or negative opinion within these messages. Exploring the methods used for sentiment analysis in Twitter health care research may allow us to better understand the options available for future research in this growing field...
April 23, 2018: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/29685450/motivators-and-barriers-for-dog-and-cat-owners-and-veterinary-surgeons-in-the-united-kingdom-to-using-preventative-medicines
#9
Zoe Belshaw, Natalie J Robinson, Rachel S Dean, Marnie L Brennan
Routine use of preventative medicines is advocated as part of responsible dog and cat ownership. However, it has been suggested that the number of owners in the United Kingdom (UK) using preventative medicines to protect their pets is in decline. The aim of this novel study was to use a qualitative methodology to explore the attitudes of pet owners and veterinary surgeons in the UK to using preventative medicine products in dogs and cats. Preventative medicine was defined as "a drug or any other preparation used to prevent disease, illness or injury...
June 1, 2018: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/29674008/applying-systems-ergonomics-methods-in-sport-a-systematic-review
#10
Adam Hulme, Jason Thompson, Katherine L Plant, Gemma J M Read, Scott Mclean, Amanda Clacy, Paul M Salmon
INTRODUCTION: As sports systems become increasingly more complex, competitive, and technology-centric, there is a greater need for systems ergonomics methods to consider the performance, health, and safety of athletes in context with the wider settings in which they operate. Therefore, the purpose of this systematic review was to identify and critically evaluate studies which have applied a systems ergonomics research approach in the context of sports performance and injury management...
April 16, 2018: Applied Ergonomics
https://www.readbyqxmd.com/read/29672265/report-formatting-in-laboratory-medicine-a-call-for-harmony
#11
Graham R D Jones, Michael Legg
The results of medical laboratory testing are only useful if they lead to appropriate actions by medical practitioners and/or patients. An underappreciated component of the medical testing process is the transfer of the information from the laboratory report into the reader's brain. The format of laboratory reports can be determined by the testing laboratory, which may issue a formatted report, or by electronic systems receiving information from laboratories and controlling the report format. As doctors can receive information from many laboratories, interpreting information from reports in a safe and rapid manner is facilitated by having similar report layouts and formats...
April 19, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29659542/secure-and-usable-user-in-a-context-continuous-authentication-in-smartphones-leveraging-non-assisted-sensors
#12
Jose Maria de Fuentes, Lorena Gonzalez-Manzano, Arturo Ribagorda
Smartphones are equipped with a set of sensors that describe the environment (e.g., GPS, noise, etc.) and their current status and usage (e.g., battery consumption, accelerometer readings, etc.). Several works have already addressed how to leverage such data for user-in-a-context continuous authentication, i.e., determining if the porting user is the authorized one and resides in his regular physical environment. This can be useful for an early reaction against robbery or impersonation. However, most previous works depend on assisted sensors, i...
April 16, 2018: Sensors
https://www.readbyqxmd.com/read/29656646/towards-a-new-brewing-control-chart-for-the-21st-century
#13
John Melrose, Borja Roman-Corrochano, Marcela Montoya-Guerra, Serafim Bakalis
This paper describes new results from a base model of brewing from a bed of packed coffee grains. The model solves for the diffusion of soluble species out of a distribution of particles into the flow through the bed pore space. It requires a limited set of input parameters. It gives a simple picture of the basics physics of coffee brewing and sets out a set of reduced variables for this process. The importance of bed extraction efficiency is elucidated. A coffee brewing control chart has been widely used to describe the region of ideal coffee brewing for some 50 years...
April 14, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29642560/near-field-chipless-radio-frequency-identification-rfid-sensing-and-identification-system-with-switching-reading
#14
Ferran Paredes, Cristian Herrojo, Javier Mata-Contreras, Miquel Moras, Alba Núñez, Eloi Ramon, Ferran Martín
A chipless radio-frequency identification (chipless-RFID) and sensing system, where tags are read by proximity (near-field) through a switch, is presented. The tags consist of a set of identical resonant elements (split-ring resonators or SRRs), printed or etched at predefined and equidistant positions, forming a linear chain, each SRR providing a bit of information. The logic state ('1' or '0') associated with each resonator depends on whether it is present or not in the predefined position. The reader is an array of power splitters used to feed a set of SRR-loaded transmission lines (in equal number to the number of resonant elements, or bits, of the tag)...
April 9, 2018: Sensors
https://www.readbyqxmd.com/read/29574195/characterizing-risk-assessments-for-the-development-of-occupational-exposure-limits-for-engineered-nanomaterials
#15
REVIEW
P A Schulte, E D Kuempel, N M Drew
The commercialization of engineered nanomaterials (ENMs) began in the early 2000's. Since then the number of commercial products and the number of workers potentially exposed to ENMs is growing, as is the need to evaluate and manage the potential health risks. Occupational exposure limits (OELs) have been developed for some of the first generation of ENMs. These OELs have been based on risk assessments that progressed from qualitative to quantitative as nanotoxicology data became available. In this paper, that progression is characterized...
March 21, 2018: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29536258/a-guide-to-missing-data-for-the-pediatric-nephrologist
#16
Nicholas G Larkins, Jonathan C Craig, Armando Teixeira-Pinto
Missing data is an important and common source of bias in clinical research. Readers should be alert to and consider the impact of missing data when reading studies. Beyond preventing missing data in the first place, through good study design and conduct, there are different strategies available to handle data containing missing observations. Complete case analysis is often biased unless data are missing completely at random. Better methods of handling missing data include multiple imputation and models using likelihood-based estimation...
March 13, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29533977/testing-of-alignment-parameters-for-ancient-samples-evaluating-and-optimizing-mapping-parameters-for-ancient-samples-using-the-tapas-tool
#17
Ulrike H Taron, Moritz Lell, Axel Barlow, Johanna L A Paijmans
High-throughput sequence data retrieved from ancient or other degraded samples has led to unprecedented insights into the evolutionary history of many species, but the analysis of such sequences also poses specific computational challenges. The most commonly used approach involves mapping sequence reads to a reference genome. However, this process becomes increasingly challenging with an elevated genetic distance between target and reference or with the presence of contaminant sequences with high sequence similarity to the target species...
March 13, 2018: Genes
https://www.readbyqxmd.com/read/29533092/inherited-blood-disorders-genetic-risk-and-global-public-health-framing-birth-defects-as-preventable-in-india
#18
Sangeeta Chattoo
This paper engages critically with the global assemblage framing sickle cell and thalassaemia disorders as a 'global health crisis'; and the promise of genomics, largely DNA-based carrier/pre-conceptual screening, prenatal diagnosis with a view to terminations, deployed in framing a solution to these historically racialised spectrum of diseases as essentially preventable. Sickle cell and thalassaemia are recessively inherited, potentially life-threatening haemoglobin disorders with significant variation of severity, often needing life-long treatment...
April 2018: Anthropology & Medicine
https://www.readbyqxmd.com/read/29515656/rediscovery-in-science-a-second-eureka-moment-a-case-in-the-neovascularization-in-cancer
#19
EDITORIAL
Denys N Wheatley
Rediscoveries are not uncommon. However, sometimes they can be more significant than confirmatory or extensions of existing findings, although many authors today refer to them as discoveries in their own right. This has led to papers repeatedly rehearsing the expression "we show here for the first time…". When a finding has opened up a whole new field of research, this is more in line with a true discovery. When particular attention is drawn to such an event by editorials in widely read journals, such as Nature , its importance is bolstered...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29445869/guidelines-for-management-of-rheumatic-diseases-in-developing-countries-from-basics-to-real-world-situation-relevance-need-and-processes-for-development
#20
REVIEW
Durga Prasanna Misra, Aman Sharma, Vikas Agarwal
Guidelines or recommendations help to provide uniform standards in medical practice. The development of guidelines requires adherence to pre-defined norms prescribed by different international organizations such as the European League against Rheumatism (EULAR). We searched Pubmed and LILACS to identify published papers in five major rheumatic diseases (rheumatoid arthritis, systemic lupus erythematosus, spondyloarthropathies, osteoarthritis, and scleroderma) from different countries based on their economic prosperity and could find a lack of published literature from most economically weaker regions...
April 2018: Rheumatology International
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