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https://www.readbyqxmd.com/read/28319882/pain-characteristics-as-important-contributing-factors-to-upper-limb-dysfunctions-in-breast-cancer-survivors-at-long-term
#1
An De Groef, Mira Meeus, Tessa De Vrieze, Lore Vos, Marijke Van Kampen, Marie-Rose Christiaens, Patrick Neven, Inge Geraerts, Nele Devoogdt
PURPOSE: The aim of this study was to explore the treatment, patient, and impairment-related risk factors associated with upper limb dysfunctions in breast cancer survivors. METHODS: A cross-sectional study was performed in 274 women treated for breast cancer. The following risk factors were analysed by bivariable and multivariable analysis: 1) treatment-related variables (type of surgery, levels of lymph node dissected, radiotherapy, chemotherapy, hormone therapy and trastuzumab); 2) patient's related variables (age and Body Mass Index); 3) and finally impairment-related variables such as pain (intensity, quality and pressure hypersensitivity, signs of central sensitisation, the degree of pain catastrophizing and vigilance and awareness to pain), active ROM and upper limb strength were investigated...
March 14, 2017: Musculoskelet Sci Pract
https://www.readbyqxmd.com/read/28319380/evaluation-and-characterization-of-trk-kinase-inhibitors-for-the-treatment-of-pain-reliable-binding-affinity-predictions-from-theory-and-computation
#2
Shunzhou Wan, Agastya P Bhati, Sarah Skerratt, Kiyoyuki Omoto, Veerabahu Shanmugasundaram, Sharan K Bagal, Peter Vivian Coveney
Optimisation of ligand binding affinity to the target protein of interest is a primary objective in small-molecule drug discovery. Until now, the prediction of binding affinities by computational methods has not been widely applied in the drug discovery process, mainly due to its lack of accuracy and reproducibility, as well as the long turnaround times required to obtain results. Herein, we report on a collaborative study that compares tropomyosin receptor kinase A (TrkA) binding affinity predictions using two recently formulated fast computational approaches - namely ESMACS (Enhanced Sampling of Molecular dynamics with Approximation of Continuum Solvent) and TIES (Thermodynamic Integration with Enhanced Sampling) - to experimentally derived TrkA binding affinities for a set of Pfizer pan-Trk compounds...
March 20, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28319024/the-prostatic-utricle-an-under-recognized-condition-resulting-in-significant-morbidity-in-boys-with-both-hypospadias-and-normal-external-genitalia
#3
Austin G Hester, Stanley J Kogan
INTRODUCTION: Pediatric presentations of a prostatic utricle have received only scant attention. Though recognized with increased frequency in boys with hypospadias, little is described about their incidence and potential for morbidity in boys with normal external genitalia. METHODS: We initially reviewed a cohort of 64 patients with hypospadias seen over a 3-year period to determine the frequency of investigative lower urinary tract studies and utricle identification...
March 1, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28301977/cognitive-complaints-in-women-with-fibromyalgia-are-they-due-to-depression-or-to-objective-cognitive-dysfunction
#4
Olga Gelonch, Maite Garolera, Joan Valls, Lluís Rosselló, Josep Pifarré
INTRODUCTION: Cognitive complaints are common in fibromyalgia, but it is unclear whether they represent an objective cognitive dysfunction or whether they could be explained by depressive symptoms. Here, we aim to elucidate the frequency of subjective cognitive complaints in a sample of women with fibromyalgia, in addition to analyzing associations between these subjective complaints and objective measures linked to the attention and executive cognitive domains. Finally, we aim to investigate the ability of demographic, clinical, and psychological variables to explain the subjective complaints observed...
March 17, 2017: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/28301890/kasuistik-late-onset-small-fiber-neuropathie-nach-kritischer-erkrankung
#5
Susanne Koch, Rabih Moshourab, Tobias Wollersheim, Claudia Spies, Thomas Fritzsche, Steffen Weber-Carstens
A 42-year-old patient presented with acute allodynia and hyperalgesia in her distal limbs, most severe in the innervation area of the ulnar nerve. The patient developed critical illness myopathy/polyneuropathy after septic shock 5 months prior to her presentation. After exclusion of differential diagnosis, "late onset small fiber neuropathy" after critical illness was diagnosed. Recent studies showed small fiber lesions during critical illness and in follow-up exams, where additionally neuropathic pain were proved...
March 2017: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
https://www.readbyqxmd.com/read/28295505/is-there-an-association-between-fear-avoidance-beliefs-and-pain-and-disability-in-patients-with-orofacial-pain
#6
Susan L Edmond, Carla S Enriquez, Michelle H Millner, Cibele Nasri-Heir, Gary M Heir
BACKGROUND: Numerous psychosocial factors have been shown to contribute to the development and perpetuation of orofacial pain. One well-recognized model for explaining the link between psychosocial factors and chronic pain is the Fear Avoidance Model. To date, this proposed link has not been studied in subjects with orofacial pain. METHODS: During the initial evaluation of subjects with orofacial pain, we collected data on fear avoidance beliefs using the Fear Avoidance Beliefs Questionnaire, and disability and pain...
March 10, 2017: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/28292301/examining-the-relationship-between-therapeutic-self-care-and-adverse-events-for-home-care-clients-in-ontario-canada-a-retrospective-cohort-study
#7
Winnie Sun, Diane M Doran, Walter P Wodchis, Elizabeth Peter
BACKGROUND: In an era of a rapidly aging population who requires home care services, clients must possess or develop therapeutic self-care ability in order to manage their health conditions safely in their homes. Therapeutic self-care is the ability to take medications as prescribed and to recognize and manage symptoms that may be experienced, such as pain. The purpose of this research study was to investigate whether therapeutic self-care ability explained variation in the frequency and types of adverse events experienced by home care clients...
March 14, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28291952/modeling-quality-of-life-in-patients-with-rheumatic-diseases-the-role-of-pain-catastrophizing-fear-avoidance-beliefs-physical-disability-and-depression
#8
Eun-Jung Shim, Bong-Jin Hahm, Dong Jin Go, Kwang-Min Lee, Hae Lim Noh, Seung-Hee Park, Yeong Wook Song
PURPOSE: To examine factors in the fear-avoidance model, such as pain, pain catastrophizing, fear-avoidance beliefs, physical disability, and depression and their relationships with physical and psychological quality of life in patients with rheumatic diseases. MATERIALS AND METHODS: The data were obtained from 360 patients with rheumatic diseases who completed self-report measures assessing study variables. Structural equation modeling was used to examine the hypothesized relationships among factors specified in the fear-avoidance model predicting physical and psychological quality of life...
March 14, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28289539/contextually-aided-recovery-care-a-scientific-theory-for-innate-healing
#9
Dave Newell, Lise R Lothe, Timothy J L Raven
BACKGROUND: The chiropractic profession emerged when scientific explanations for causes of health and disease were still in infancy and the co-existence of notions such as innate healing and vitalism were perhaps admissible within such a historical context. Notwithstanding, within the scientific culture of the 21(st) Century all healthcare paradigms require evidential support which in regard these early concepts are in large part, absent. Nevertheless, a large body of emerging scientific evidence supports the existence of innate healing phenomena that may explain a plethora of clinical outcomes observed during chiropractic care...
2017: Chiropractic & Manual Therapies
https://www.readbyqxmd.com/read/28289243/use-of-standard-risk-screening-and-assessment-forms-to-prevent-harm-to-older-people-in-australian-hospitals-a-mixed-methods-study
#10
Bernice Redley, Michelle Raggatt
BACKGROUND: Standard risk screening and assessment forms are frequently used in strategies to prevent harm to older people in hospitals. Little is known about good practices for their use. OBJECTIVE: Scope the preventable harms addressed by standard forms used to screen and assess older people and how standard forms are operationalised in hospitals across Victoria, Australia. METHODS: Mixed methods study: (1) cross-sectional audit of the standard risk screening and assessment forms used to assess older people at 11 health services in 2015; (2) nine focus groups with a purposive sample of 69 participants at 9 health services...
March 13, 2017: BMJ Quality & Safety
https://www.readbyqxmd.com/read/28287775/musculoskeletal-complaints-anxiety-depression-symptoms-and-neuroticism-a-study-of-middle-aged-twins
#11
Olav Vassend, Espen Røysamb, Christopher Sivert Nielsen, Nikolai Olavi Czajkowski
BACKGROUND: Musculoskeletal (MS) complaints are reported commonly, but the extent to which such complaints reflect the severity of site-specific pathology or a more generalized susceptibility to feel pain/discomfort is uncertain. Both site-specific and more widespread MS conditions have been shown to be linked to anxiety and depression, but the nature of this relationship is poorly understood. In the present study the role of neuroticism as a shared risk factor that may possibly explain the co-occurrence between anxiety-depression and MS complaints was investigated...
March 13, 2017: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
https://www.readbyqxmd.com/read/28286493/attachment-style-and-chronic-pain-toward-an-interpersonal-model-of-pain
#12
Annunziata Romeo, Valentina Tesio, Gianluca Castelnuovo, Lorys Castelli
Chronic pain (CP) is a burdensome symptom. Different psychological models have been proposed to explain the role of psychological and social factors in developing and maintaining CP. Attachment, for example, is a psychological construct of possible relevance in CP. The first studies on the role of attachment in CP did not investigate the partner's psychological factors, thus neglecting the influence of the latter. The main aim of this mini-review was to examine the more recent literature investigating the relationship between CP and attachment style...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28286178/vagus-nerve-stimulation-suppresses-acute-noxious-activation-of-trigeminocervical-neurons-in-animal-models-of-primary-headache
#13
Simon Akerman, Bruce Simon, Marcela Romero-Reyes
Vagus nerve stimulation (VNS) has been reported to be effective in the abortive treatment of both migraine and cluster headache. Using validated animal models of acute dural-intracranial (migraine-like) and trigeminal-autonomic (cluster-like) head pain we tested whether VNS suppresses ongoing and nociceptive-evoked firing of trigeminocervical neurons to explain its abortive effects in migraine and cluster headache. Unilateral VNS was applied invasively via hook electrodes placed on the vagus nerve. A single dose of ipsilateral or contralateral VNS, to trigeminal recording and dural-stimulating side, suppressed ongoing spontaneous and noxious dural-evoked trigeminocervical neuronal firing...
March 9, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/28282730/racial-and-ethnic-differences-in-psychotropic-medication-use-among-community-dwelling-persons-with-dementia-in-the-united-states
#14
Elsie L Grace, Rebecca S Allen, Keisha Ivey, Shannon M Knapp, Louis D Burgio
OBJECTIVES: Little is known about the patterns of psychotropic medication use in community-dwelling minority persons with dementia (PWD). The purpose of this study was to investigate racial/ethnic differences in psychotropic medication use across a diverse population of community-dwelling PWD and to examine the extent to which caregiver characteristics influence this use. METHOD: Data were drawn from the baseline assessment of the Resources for Enhancing Alzheimer's Caregiver Health II trial...
February 16, 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/28279704/beliefs-about-pharmaceutical-medicines-and-natural-remedies-explain-individual-variation-in-placebo-analgesia
#15
Andrew Watkinson, Sarah C E Chapman, Rob Horne
This study examined whether placebo responses were predicted by a theoretical model of specific and general treatment beliefs. Using a randomised cross-over, experimental design (168 healthy individuals) we assessed whether responses to a cold pressor task were influenced by two placebo creams described as Pharmaceutical vs Natural origin. We assessed whether placebo responses were predicted by pre-treatment beliefs about the treatments (placebo) and by beliefs about the pain. The efficacy of both Pharmaceutical and Natural Placebos in reducing Pain Intensity was predicted by aspects of pain catastrophizing including Feelings of Helplessness (Pharmaceutical: B=0...
March 6, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28278366/development-and-validation-of-a-condition-specific-measure-for-chronic-periodontitis-oral-health-impact-profile-for-chronic-periodontitis-ohip-cp
#16
Songlin He, Jinhua Wang, Shicheng Wei, Ping Ji
AIM: The aim of this study was to develop and validate the first condition-specific tool to assess oral health-related quality of life (OHRQoL) impairment in association with chronic periodontitis and to use it as an outcome measure in clinical trials. METHODS: Twenty-three potential items were developed using a combined method consisting of a literature review, semi-structured patient interviews (n=20) and expert panel 1. Subsequently, item selection was carried out by means of qualitative content analysis and quantitative classical test theory (CTT) with 110 patients and expert panel 2...
March 9, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28275316/cohort-description-the-danish-study-of-functional-disorders
#17
Thomas Meinertz Dantoft, Jeanette Frost Ebstrup, Allan Linneberg, Sine Skovbjerg, Anja Lykke Madsen, Jesper Mehlsen, Louise Brinth, Lene Falgaard Eplov, Tina Wisbech Carstensen, Andreas Schroder, Per Klausen Fink, Erik Lykke Mortensen, Torben Hansen, Oluf Pedersen, Torben Jørgensen
The Danish study of Functional Disorders (DanFunD) cohort was initiated to outline the epidemiology of functional somatic syndromes (FSS) and is the first larger coordinated epidemiological study focusing exclusively on FSS. FSS are prevalent in all medical settings and can be defined as syndromes that, after appropriate medical assessment, cannot be explained in terms of a conventional medical or surgical disease. FSS are frequent and the clinical importance varies from vague symptoms to extreme disability...
2017: Clinical Epidemiology
https://www.readbyqxmd.com/read/28270756/role-of-the-lateral-habenula-in-pain-associated-depression
#18
Yanhui Li, Yumeng Wang, Chengluan Xuan, Yang Li, Lianhua Piao, Jicheng Li, Hua Zhao
Patients with chronic pain have significantly higher incidences of depression and anxiety than the average person. However, the mechanism underlying this link has not been elucidated in terms of how chronic pain causes significant mood changes and further develops into severe anxiety or depression. The serotonergic system in the raphe nuclei is an important component in both pain processing and the pathogenesis of depression. Since the lateral habenular nucleus (LHb) controls the raphe nuclei, it may participate in the regulation of pain-associated depression...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28267634/chronic-low-back-pain-and-the-risk-of-depression-or-anxiety-symptoms-insights-from-a-longitudinal-twin-study
#19
Matt Fernandez, Lucia Colodro-Conde, Jan Hartvigsen, Manuela L Ferreira, Kathryn M Refshauge, Marina B Pinheiro, Juan R Ordoñana, Paulo H Ferreira
BACKGROUND CONTEXT: Pain is commonly associated with symptoms of depression or anxiety, although this relationship is considered bidirectional. There is limited knowledge regarding causal relationships. PURPOSE: This study aims to investigate whether chronic low back pain (LBP) increases the risk of depression or anxiety symptoms, after adjusting for shared familial factors. STUDY DESIGN: This is a longitudinal, genetically informative study design from the Murcia Twin Registry in Spain...
March 4, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28267630/psychometric-evaluation-of-the-pain-attitudes-questionnaire-revised-for-people-with-advanced-cancer
#20
Kenneth Mah, Kim T Tran, Lynn R Gauthier, Gary Rodin, Camilla Zimmermann, David Warr, S Lawrence Librach, Malcolm Moore, Frances A Shepherd, Lucia Gagliese
Pain-related stoicism and cautiousness are theorized to be more prevalent in older than younger patients and to lead to greater pain underreporting and consequently inadequate pain management in older patients. The Pain Attitudes Questionnaire-Revised (PAQ-R), which measures five pain-related stoicism (fortitude, concealment, superiority) and cautiousness (self-doubt, reluctance) factors in chronic pain, can help test this hypothesis in advanced cancer but requires validation. We conducted a psychometric evaluation of the PAQ-R in 155 younger (< 60 years) and 114 older (≥ 60 years) patients with advanced cancer...
March 3, 2017: Journal of Pain: Official Journal of the American Pain Society
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