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https://www.readbyqxmd.com/read/29055075/association-between-genetic-polymorphisms-and-pain-sensitivity-in-patients-with-hip-osteoarthritis
#1
Anne E Olesen, Lecia M Nielsen, Søren Feddersen, Joachim Erlenwein, Frank Petzke, Michael Przemeck, Lona L Christrup, Asbjørn M Drewes
BACKGROUND: Factors such as age, gender and genetic polymorphisms may explain individual difference in pain phenotype. Genetic associations to pain sensitivity have previously been investigated in osteoarthritis patients with focus on the P2X7, TRPV1 and TACR1 genes. However, other genes may play a role as well. Osteoarthritis is a common joint disease and many patients suffering from this disease are thought to have increased sensitivity to noxious stimuli resulting from sensitization in the nociceptive system...
October 20, 2017: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/29054749/men-with-unilateral-achilles-tendinopathy-have-impaired-balance-on-the-symptomatic-side
#2
M Scholes, S Stadler, D Connell, C Barton, R A Clarke, A L Bryant, P Malliaras
OBJECTIVES: To investigate single leg standing balance in males with mid-portion Achilles tendinopathy (AT). DESIGN: Cross sectional case study. METHODS: Centre of pressure (COP) path length was measured using a Wii Balance Board (WBB) in 21 male participants (20-60 years) with unilateral mid-portion AT during single-limb standing on each limb with eyes open and closed. Ultrasound imaging of both Achilles tendons was also performed by one blinded assessor, and the anteroposterior (AP) thickness and presence of pathology was determined...
October 6, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/29042092/quality-of-life-after-surgical-treatment-of-coarctation-in-long-term-follow-up-coafu-predictive-value-of-clinical-variables
#3
Pinar Bambul Heck, Jelena Pabst von Ohain, Harald Kaemmerer, Peter Ewert, Alfred Hager
BACKGROUND: We sought to analyze the quality of life and the predictive value of clinical variables from previous follow-up study in patients late after surgical treatment of aortic coarctation on the quality of life. METHODS: All patients, who have participated in the prospective cross-sectional COALA Study in 2000 with a structural clinical investigation including blood pressure measurement and symptom-limited exercise test were contacted for the health-related quality of life questionnaire SF-36 from January 2013 through December 2014...
October 9, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29040539/explaining-recent-mortality-trends-among-younger-and-middle-aged-white-americans
#4
Ryan K Masters, Andrea M Tilstra, Daniel H Simon
Background: Recent research has suggested that increases in mortality among middle-aged US Whites are being driven by suicides and poisonings from alcohol and drug use. Increases in these 'despair' deaths have been argued to reflect a cohort-based epidemic of pain and distress among middle-aged US Whites. Methods: We examine trends in all-cause and cause-specific mortality rates among younger and middle-aged US White men and women between 1980 and 2014, using official US mortality data...
July 19, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29036858/musculoskeletal-signs-in-female-homecare-personnel-a-longitudinal-epidemiological-study
#5
Gunnar Lundberg, Björn Gerdle
BACKGROUND: In Sweden, homecare services take care of elderly and disabled people, work that often requires heavy lifting and forward bending, resulting in high prevalences of pain and work accidents. OBJECTIVE: Using an eight-year follow-up, this study determines the prognostic importance of certain musculoskeletal signs reported in earlier studies [1, 2] with respect to aspects of pain and perceived disability. METHODS: Baseline data has been reported in earlier studies of 607 women [1-3]...
October 8, 2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/29036699/pain-related-acceptance-as-a-mediator-in-the-fear-avoidance-model-of-chronic-pain-a-preliminary-study
#6
Sophie Lykkegaard Ravn, Maria Louison Vang, Henrik Bjarke Vaegter, Tonny Elmose Andersen
Objective: The fear avoidance model has served as a popular, heuristic model in explaining the transition from acute to chronic pain. In addition, the significance of pain-related acceptance in chronic pain development and adjustment is underlined in a vast number of empirical studies. The objective of the current preliminary study was to investigate pain-related acceptance as a mediator within the key cognitive relationships proposed by the fear avoidance model of chronic pain. Materials and Methods: In a cross-sectional design, bodily pain, pain catastrophizing, fear avoidance beliefs, and pain-related acceptance were assessed by questionnaires in 125 chronic pain patients in a Danish multidisciplinary pain center...
September 23, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29035799/use-of-the-endometriosis-fertility-index-in-daily-practice-a-prospective-evaluation
#7
J Boujenah, I Cedrin-Durnerin, C Herbemont, A Bricou, C Sifer, C Poncelet
OBJECTIVE: To perform a prospective evaluation of postoperative fertility management using the endometriosis fertility index (EFI). STUDY: This prospective non-interventional observational study was performed from January 2013 to February 2016 in a tertiary care university hospital and an assisted reproductive technology (ART) centre. In total, 196 patients underwent laparoscopic surgery for endometriosis-related infertility. Indications for surgery included pelvic pain (dysmenorrhoea, and/or deep dyspareunia), abnormal hysterosalpingogram, and failure to conceive after three or more superovulation cycles with or without intra-uterine insemination...
October 10, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29035178/patient-perspectives-on-communication-with-primary-care-physicians-about-chronic-low-back-pain
#8
Sarah Evers, Clarissa Hsu, Karen J Sherman, Ben Balderson, Rene Hawkes, Georgie Brewer, Anne-Marie La Porte, John Yeoman, Dan Cherkin
OBJECTIVES: Chronic low back pain (CLBP) is a common health problem with challenges for providing satisfactory care. This study was undertaken to identify opportunities to improve key aspects of physicians' communications with CLBP-affected patients. METHODS: A series of 3 focus groups, each with 7 to 11 patients with CLBP, were recruited from primary care settings and grouped by risk level of reduced function resulting from back pain, to elicit perspectives about interactions with their primary care physicians...
2017: Permanente Journal
https://www.readbyqxmd.com/read/29035124/pain-and-alcohol-use-among-latinos-in-primary-care-examining-rumination-as-an-explanatory-factor
#9
Daniel J Paulus, Joseph W Ditre, Andres G Viana, Jafar Bakhshaie, Monica Garza, Jeanette Valdivieso, Melissa Ochoa-Perez, Chad Lemaire, Michael J Zvolensky
BACKGROUND: Alcohol is a widely abused substance among Latinos. Yet, little is known regarding factors underlying hazardous drinking in this population. Growing work has linked pain to hazardous drinking, although highly limited work has focused on Latinos. OBJECTIVES: The aim of the current study was to test rumination as an underlying mechanism explaining relations between pain severity and alcohol use among Latinos. METHODS: Data from 252 low-income Latino adults (Mage = 38...
October 16, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/29033539/possible-association-between-subtypes-of-dry-eye-disease-and-seasonal-variation
#10
Masahiko Ayaki, Motoko Kawashima, Miki Uchino, Kazuo Tsubota, Kazuno Negishi
PURPOSE: The purpose of this study was to evaluate the influence of seasons on the signs and symptoms of dry eye disease (DED). METHODS: This is a cross-sectional, case-control study, and participants were non-DED subjects (n=1,916, mean age 54.4±14.4 years) and DED patients (n=684, 54.2±12.1 years) visiting six eye clinics at various practices and locations in Japan. We evaluated the signs and symptoms of DED and the seasons with the most severe results were compared to those with the least severe results in both groups...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29025967/diminazene-is-a-slow-pore-blocker-of-acid-sensing-ion-channel-1a-asic1a
#11
Axel Schmidt, Giulia Rossetti, Sylvia Joussen, Stefan Grunder
Acid-sensing ion channels (ASICs) are neuronal receptors for extracellular protons. They contribute to the excitatory postsynaptic current and to the detection of painful acidosis. Moreover, they are activated during peripheral inflammation and acidosis associated with various neuronal disorders such as stroke and neuro-inflammation, rendering them interesting drug targets. Diminazene aceturate is a small molecule inhibitor of ASICs with a reported apparent affinity in the low micromolar range, making it an interesting lead compound...
October 12, 2017: Molecular Pharmacology
https://www.readbyqxmd.com/read/29025157/chronic-pain-after-traumatic-brain-injury-pathophysiology-and-pain-mechanisms
#12
Karen-Amanda Irvine, J David Clark
Background: Traumatic brain injury refers to a broad range of neurological, cognitive, and emotional factors that result from the application of an external force to the head. Individuals recovering from traumatic brain injury will frequently experience acute and chronic pain. Objective: The objective of this paper is to discuss the pathophysiological changes resulting from traumatic brain injury and how these may be involved in the development and persistence of pain after injury...
August 29, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29024961/epidural-fat-and-its-association-with-pain-physical-function-and-disability-among-older-adults-with-low-back-pain-and-controls
#13
Jaclyn Megan Sions, Christina Angelica Rodriguez, Ryan Todd Pohlig, Gregory Evan Hicks, Peter Charles Coyle
Objective: To examine epidural fat and its relationship to pain, physical function, and disability among older adults with chronic low back pain, chronic low back pain plus leg pain, and controls. Design: Cross-sectional, comparative study. Setting: Standardized examinations were conducted in a research laboratory, and magnetic resonance images were obtained. Subjects: A total of 93 adults age 60 to 85 years (24 with chronic back pain, 25 with chronic back pain plus leg pain, and 44 controls)...
September 14, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29022686/level-of-education-as-a-risk-factor-for-extensive-prevalence-of-cervical-intervertebral-disc-degenerative-changes-and-chronic-neck-pain
#14
Vedran Markotić, Damir Zubac, Miro Miljko, Goran Šimić, Amra Zalihić, Gojko Bogdan, Dorijan Radančević, Ana Dugandžić Šimić, Josip Mašković
OBJECTIVE: The aim of this study was to document the prevalence of degenerative intervertebral disc changes in the patients who previously reported symptoms of neck pain and to determine the influence of education level on degenerative intervertebral disc changes and subsequent chronic neck pain. METHODS: One hundred and twelve patients were randomly selected from the University Hospital in Mostar, Bosna and Herzegovina, (aged 48.5±12.7 years) and submitted to magnetic resonance imaging (MRI) of the cervical spine...
September 2017: Central European Journal of Public Health
https://www.readbyqxmd.com/read/29019415/pain-characteristics-of-older-persons-with-medically-unexplained-symptoms-older-persons-with-medically-explained-symptoms-and-older-persons-with-depression
#15
Denise J C Hanssen, Peter L B J Lucassen, Paul Naarding, Margot W M de Waal, Richard C Oude Voshaar
OBJECTIVES: The main objective of the current study is to compare chronic pain characteristics of older patients with Medically Unexplained Symptoms (MUS), to those of patients with Medically Explained Symptoms (MES), and to those of patients with Major Depressive Disorder (MDD). METHOD: By combining data from the OPUS and NESDO study, we compared pain characteristics of 102 older (>60 years) MUS-patients to 145 older MES-patients and 275 older MDD-patients in a case-control study design...
October 11, 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/29017382/which-factors-are-associated-with-the-recurrence-of-endometrioma-after-cystectomy
#16
Mehmet Küçükbaş, Meryem Kurek Eken, Gülşah İlhan, Taylan Şenol, Dilşad Herkiloğlu, Bilge Kapudere
Endometrioma is the most common form of endometriosis and is a sign of wide-spread disease in symptomatic patients. Medical treatment options can be successful in endometrioma smaller than 1 cm, but ineffective for growing and symptomatic endometriomas. Conservative surgical interventions that preserve fertility, such as laparoscopic removal or destruction of endometriotic tissue or aspiration of cystic content are typically used to treat the condition. One of the most frustrating aspects of endometrioma treatment is disease recurrence...
October 10, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28993838/delta-opioid-receptor-expression-and-function-in-primary-afferent-somatosensory-neurons
#17
Amaury François, Grégory Scherrer
The functional diversity of primary afferent neurons of the dorsal root ganglia (DRG) generates a variety of qualitatively and quantitatively distinct somatosensory experiences, from shooting pain to pleasant touch. In recent years, the identification of dozens of genetic markers specifically expressed by subpopulations of DRG neurons has dramatically improved our understanding of this diversity and provided the tools to manipulate their activity and uncover their molecular identity and function. Opioid receptors have long been known to be expressed by discrete populations of DRG neurons, in which they regulate cell excitability and neurotransmitter release...
October 10, 2017: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/28992894/chronic-prostatitis-and-comorbid-non-urological-overlapping-pain-conditions-a-co-twin-control-study
#18
Marianna Gasperi, John N Krieger, Christopher Forsberg, Jack Goldberg, Dedra Buchwald, Niloofar Afari
OBJECTIVES: Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is characterized by pain and voiding symptoms in the absence of an obvious infection or other cause. CP/CPPS frequently occurs with non-urological chronic overlapping pain conditions (COPCs) of unknown etiology. We conducted a co-twin control study in men discordant for chronic prostatitis (CP), an overarching diagnosis of which approximately 90% is CP/CPPS. The primary aim was to investigate the contribution of familial factors, including shared genetic and common environmental factors, to the comorbidity of CP and COPCs...
November 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28992609/type-d-personality-in-patients-with-upper-extremity-musculoskeletal-illness-internal-consistency-structural-validity-and-relationship-to-pain-interference
#19
Mojtaba Talaei-Khoei, Amin Mohamadi, Stefan F Fischerauer, David Ring, Ana-Maria Vranceanu
OBJECTIVE: Type D personality - the joint tendency toward negative affectivity (NA) and social inhibition (SI) - is associated with greater symptom perception and negative health outcomes among various patient populations. We investigated Type D personality among patients with upper extremity musculoskeletal illness. METHOD: In cross-sectional design, we estimated the prevalence of Type D personality in this population and explored the associations of two different Type D conceptualizations (i...
September 27, 2017: General Hospital Psychiatry
https://www.readbyqxmd.com/read/28991940/posttraumatic-stress-disorder-often-missed-in-primary-care
#20
Adrienne A Williams
DeSean W, a 47-year-old man, returned to his primary care clinic with a new complaint of epigastric burning that had been bothering him for the past 4 months. He had tried several over-the-counter remedies, which provided no relief. He also remained concerned--despite assurances to the contrary at previous clinic visits--that he had contracted a sexually-transmitted disease (STD) after going to a bar one night 4 to 5 months ago. At 2 other clinic visits since that time, STD test results were negative. At this current visit, symptoms and details of sexual history were unchanged since the last visit, with the exception of the epigastric pain...
October 2017: Journal of Family Practice
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