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https://www.readbyqxmd.com/read/29651791/a-discrete-event-simulation-model-to-assess-the-economic-value-of-a-hypothetical-pharmacogenomics-test-for-statin-induced-myopathy-in-patients-initiating-a-statin-in-secondary-cardiovascular-prevention
#1
Dominic Mitchell, Jason R Guertin, Anick Dubois, Marie-Pierre Dubé, Jean-Claude Tardif, Ange Christelle Iliza, Fiorella Fanton-Aita, Alexis Matteau, Jacques LeLorier
BACKGROUND: Statin (HMG-CoA reductase inhibitor) therapy is the mainstay dyslipidemia treatment and reduces the risk of a cardiovascular (CV) event (CVE) by up to 35%. However, adherence to statin therapy is poor. One reason patients discontinue statin therapy is musculoskeletal pain and the associated risk of rhabdomyolysis. Research is ongoing to develop a pharmacogenomics (PGx) test for statin-induced myopathy as an alternative to the current diagnosis method, which relies on creatine kinase levels...
April 12, 2018: Molecular Diagnosis & Therapy
https://www.readbyqxmd.com/read/29649035/pharmacological-characterization-of-levorphanol-a-g-protein-biased-opioid-analgesic
#2
Valerie Le Rouzic, Ankita Narayan, Amanda Hunkle, Gina F Marrone, Zhigang Lu, Susruta Majumdar, Jin Xu, Ying-Xian Pan, Gavril W Pasternak
BACKGROUND: Levorphanol is a potent analgesic that has been used for decades. Most commonly used for acute and cancer pain, it also is effective against neuropathic pain. The recent appreciation of the importance of functional bias and the uncovering of multiple µ opioid receptor splice variants may help explain the variability of patient responses to different opioid drugs. METHODS: Here, we evaluate levorphanol in a variety of traditional in vitro receptor binding and functional assays...
April 11, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29649012/clinical-improvements-are-not-explained-by-changes-in-tendon-structure-on-utc-following-an-exercise-program-for-patellar-tendinopathy
#3
Mathijs van Ark, Ebonie Rio, Jill Cook, Inge van den Akker-Scheek, James E Gaida, Johannes Zwerver, Sean Docking
OBJECTIVES: The aim of this study was to investigate the effects of a 4-week in-season exercise program of isometric or isotonic exercises on tendon structure and dimensions as quantified by Ultrasound Tissue Characterization (UTC). DESIGN: Randomized clinical trial. Volleyball and basketball players (16-31 years, n=29) with clinically diagnosed patellar tendinopathy were randomized to a 4-week isometric or isotonic exercise program. The programs were designed to decrease patellar tendon pain...
April 11, 2018: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/29648854/potential-mechanisms-involved-in-the-effect-of-cognitive-behavioral-therapy-on-fatigue-severity-in-type-1-diabetes
#4
Juliane Menting, Cees J Tack, Rogier Donders, Hans Knoop
OBJECTIVE: To identify mediators of the beneficial effect of cognitive-behavioral therapy (CBT) on fatigue severity in chronically fatigued patients with Type 1 diabetes. METHOD: We performed secondary analyses of a randomized controlled trial testing the efficacy of CBT. Primary outcome was fatigue severity assessed with the Checklist Individual Strength, subscale fatigue severity. We used multiple mediation analysis to determine potential mediators of the treatment effect...
April 2018: Journal of Consulting and Clinical Psychology
https://www.readbyqxmd.com/read/29629615/optimal-screening-for-prediction-of-referral-and-outcome-ospro-for-musculoskeletal-pain-conditions-results-from-the-validation-cohort
#5
Steven Z George, Jason M Beneciuk, Trevor A Lentz, Samuel S Wu, Yunfeng Dai, Joel E Bialosky, Giorgio Zeppieri
Study Design Observational, prospective cohort. Background Musculoskeletal pain is a common reason to seek healthcare and earlier non-pharmacological treatment and enhancement of personalized care options are two high priority areas. Validating concise assessment tools is an important step in establishing better care pathways. Objectives To determine the predictive validity of Optimal Screening for Prediction of Referral and Outcome (OSPRO) tools for individuals with neck, low back, shoulder, or knee pain. Methods A convenience sample (n = 440) was gathered by Orthopaedic Physical Therapy-Investigator Network clinics (n = 9)...
April 7, 2018: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/29626143/opioid-analgesia-on-the-battlefield-a-retrospective-review-of-data-from-operation-herrick
#6
Pip Lewis, C Wright, C Hooper
BACKGROUND: Acute pain secondary to trauma is commonly encountered on the battlefield. The use of morphine to manage pain during combat has been well established since the 19th century. Despite this, there is relatively little research on analgesia use in this environment. This study aims to review the use and complications of morphine and other opioids during Operation HERRICK. METHODS: A database search of the Joint Theatre Trauma Registry was completed looking for all incidences of morphine, fentanyl or naloxone use from February 2007 to September 2014...
April 6, 2018: Journal of the Royal Army Medical Corps
https://www.readbyqxmd.com/read/29625603/postural-awareness-and-its-relation-to-pain-validation-of-an-innovative-instrument-measuring-awareness-of-body-posture-in-patients-with-chronic-pain
#7
Holger Cramer, Wolf E Mehling, Felix J Saha, Gustav Dobos, Romy Lauche
BACKGROUND: Habitual postural patterns are associated with musculoskeletal pain, and improving a maladaptive posture requires postural awareness in order to lead to clinical improvements. This study aimed to develop and evaluate the psychometric properties of an innovative postural awareness scale. METHODS: A 12-item Postural Awareness Scale (PAS) was developed and administered to 512 chronic pain patients (50.3 ± 11.4 years, 91.6% female, 37.1% spinal/shoulder pain) to assess its factor structure and reliability...
April 6, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29625412/which-is-the-best-predictor-of-excessive-hip-internal-rotation-in-women-with-patellofemoral-pain-rearfoot-eversion-or-hip-muscle-strength-exploring-subgroups
#8
Amanda Schenatto Ferreira, Danilo de Oliveira Silva, Ronaldo Valdir Briani, Deisi Ferrari, Fernando Amâncio Aragão, Marcella Ferraz Pazzinatto, Fábio Mícolis de Azevedo
BACKGROUND: Patellofemoral pain (PFP) has been linked to increased patellofemoral joint stress as a result of excessive hip internal rotation. Lower hip strength and/or excessive rearfoot eversion have been used to explain such altered movement pattern; however, it is unknown which one is the best predictor of excessive hip internal rotation. RESEARCH QUESTION: To investigate if peak rearfoot eversion and/or peak concentric hip abductor strength can predict peak hip internal rotation during stair ascent in women with PFP...
March 26, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29625231/the-oxidized-linoleic-acid-metabolite-12-13-dihome-mediates-thermal-hyperalgesia-during-inflammatory-pain
#9
Béla Zimmer, Carlo Angioni, Tabea Osthues, Andy Toewe, Dominique Thomas, Sandra C Pierre, Gerd Geisslinger, Klaus Scholich, Marco Sisignano
Eicosanoids play a crucial role in inflammatory pain. However, there is very little knowledge about the contribution of oxidized linoleic acid metabolites in inflammatory pain and peripheral sensitization. Here, we identify 12,13-dihydroxy-9Z-octadecenoic acid (12,13-DiHOME), a cytochrome P450-derived linoleic acid metabolite, as crucial mediator of thermal hyperalgesia during inflammatory pain. We found 12,13-DiHOME in increased concentrations in peripheral nervous tissue during acute zymosan- and complete Freund's Adjuvant-induced inflammatory pain...
April 3, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29623059/cognitive-impairments-in-fibromyalgia-syndrome-associations-with-positive-and-negative-affect-alexithymia-pain-catastrophizing-and-self-esteem
#10
Carmen M Galvez-Sánchez, Gustavo A Reyes Del Paso, Stefan Duschek
Fibromyalgia syndrome (FMS) is a chronic condition characterized by widespread pain accompanied by symptoms like depression, anxiety, sleep disturbance and fatigue. In addition, affected patients frequently report cognitive disruption such as forgetfulness, concentration difficulties or mental slowness. Though cognitive deficits in FMS have been confirmed in various studies, not much is known about the mechanisms involved in their origin. This study aimed to investigate the contribution of affect-related variables to cognitive impairments in FMS...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29621662/plasma-membrane-depolarization-and-permeabilization-due-to-electric-pulses-in-cell-lines-of-different-excitability
#11
Janja Dermol-Černe, Damijan Miklavčič, Matej Reberšek, Primož Mekuč, Sylvia M Bardet, Ryan Burke, Delia Arnaud-Cormos, Philippe Leveque, Rodney O'Connor
In electroporation-based medical treatments, excitable tissues are treated, either intentionally (irreversible electroporation of brain cancer, gene electrotransfer or ablation of the heart muscle, gene electrotransfer of skeletal muscles), or unintentionally (excitable tissues near the target area). We investigated how excitable and non-excitable cells respond to electric pulses, and if electroporation could be an effective treatment of the tumours of the central nervous system. For three non-excitable and one excitable cell line, we determined a strength-duration curve for a single pulse of 10ns-10ms...
March 21, 2018: Bioelectrochemistry
https://www.readbyqxmd.com/read/29621638/proving-cortical-death-after-vascular-coma-evoked-potentials-eeg-and-neuroimaging
#12
Florent Gobert, Frederic Dailler, Catherine Fischer, Nathalie André-Obadia, Jacques Luauté
OBJECTIVES: Several studies have shown that bilateral abolition of somatosensory evoked potentials after a nontraumatic coma has 100% specificity for nonawakening with ethical consequences for active care withdrawal. We propose to evaluate the prognostic value of bilateral abolished cortical components of SEPs in severe vascular coma. METHODS: A total of 144 comatose patients after subarachnoid haemorrhage were evaluated by multimodal evoked potentials (EPs); 7 patients presented a bilateral abolition of somatosensory and auditory EPs...
March 17, 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29620949/associations-between-race-and-dementia-status-and-the-quality-of-end-of-life-care
#13
Elizabeth A Luth, Holly G Prigerson
BACKGROUND: Non-Hispanic black and dementia patients receive more invasive and futile treatment at end of life (EOL) relative to others. Little is known about the relationship between race/ethnicity, dementia, and EOL care quality. OBJECTIVE: Identify the relationship between race/ethnicity, dementia, and proxy reporters' evaluation of EOL care quality in older adults. DESIGN: Latent class analysis (LCA) of national survey data. SETTING: 1588 deceased Medicare beneficiaries age 65 and older from the National Health and Aging Trends Study (2011-2016)...
April 5, 2018: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/29620648/epiduroscopic-laser-neural-decompression-as-a-treatment-for-migrated-lumbar-disc-herniation-case-series
#14
Jinyoung Oh, Daehyun Jo
OBJECTIVE: Epiduroscopic laser neural decompression (ELND) is one of the more invasive techniques for managing patients with herniated lumbar disc. However, ELND can be used to treat, and diagnose the epidural pathology; indications for ELND remain controversial, especially, when applied in cases of large disc extrusion and migrated disc. This paper reports cases of patients that were satisfied with the ELND procedure for migrated lumbar disc herniation. METHODS: We reviewed the medical records of patients that received ELND for migrated lumbar disc in an outpatient clinic...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29619928/studies-of-upper-limb-pain-in-occupational-medicine-in-general-practice-and-among-computer-operators
#15
Jørgen Riis Jepsen
Diagnostic consensus criteria cannot be applied in a major proportion of patients with upper limb complaints, many of which are regarded as "non-specific". The three empirical studies in this thesis aimed to address this diagnostic challenge by incorporating representative neurological qualities in the physical examination.
Patterns of muscle weakness, sensory abnormalities and nerve trunk allodynia based on the nerves' topography and their motor and cutaneous innervation were defined to reflect peripheral nerve afflictions and their locations...
April 2018: Danish Medical Journal
https://www.readbyqxmd.com/read/29618118/neural-mechanisms-of-the-rejection-aggression-link
#16
David S Chester, Donald R Lynam, Richard Milich, C Nathan DeWall
Social rejection is a painful event that often increases aggression. However, the neural mechanisms of this rejection-aggression link remain unclear. A potential clue may be that rejected people often recruit the ventrolateral prefrontal cortex's (VLPFC) self-regulatory processes to manage the pain of rejection. Using functional MRI, we replicated previous links between rejection and activity in the brain's mentalizing network, social pain network, and VLPFC. VLPFC recruitment during rejection was associated with greater activity in the brain's reward network (i...
March 28, 2018: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/29616222/does-a-better-perfusion-of-deconditioned-muscle-tissue-release-chronic-low-back-pain
#17
Paola Valdivieso, Martino V Franchi, Christian Gerber, Martin Flück
Non-specific chronic low back pain (nsCLBP) is a multifactorial condition of unknown etiology and pathogenesis. Physical and genetic factors may influence the predisposition of individuals to CLBP, which in many instances share a musculoskeletal origin. A reduced pain level in low back pain patients that participate in exercise therapy highlights that disuse-related muscle deconditioning may predispose individuals to nsCLBP. In this context, musculoskeletal pain may be the consequence of capillary rarefaction in inactive muscle as this would lower local tissue drainage and washing out of toxic waste...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29614629/genetic-modifiers-of-severity-in-sickle-cell-disease
#18
Alicia K Chang, Carly C Ginter Summarell, Parendi T Birdie, Vivien A Sheehan
Sickle cell disease (SCD) is one of the most common single disease disorders world-wide. It is remarkable for its clinical heterogeneity, even among individuals with identical genotypes. Some individuals experience morbidity and mortality in early childhood, while others have a relatively mild course, and normal or near normal life expectancy. Many clinical complications are associated with SCD; most notably frequent pain episodes, stroke, acute chest syndrome, avascular necrosis, nephropathy, retinopathy and pulmonary hypertension...
2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29611292/vitamin-d-deficiency-is-associated-with-ethnicity-and-knee-pain-in-a-multi-ethnic-south-east-asian-nation-results-from-malaysian-elders-longitudinal-research-melor
#19
Sumaiyah Mat, Mohamad Hasif Jaafar, Sargunan Sockalingam, Jasmin Raja, Shahrul Bahyah Kamaruzzaman, Ai-Vyrn Chin, Azlina Amir Abbas, Chee Ken Chan, Noran Naqiah Hairi, Sajaratulnisah Othman, Robert Cumming, Maw Pin Tan
AIM: To determine the association between vitamin D and knee pain among participants of the Malaysian Elders Longitudinal Research (MELoR) study. METHOD: This was a cross-sectional study from the MELoR study consisting of a representative group of 1011 community-dwelling older persons (57% female), mean age 86.5 (54-94) years; 313 were Malays, 367 Chinese and 330 Indians. Participants were asked if they had knee pain. Levels of serum 25-hydroxy cholecalciferol (25-[OH]D), an indicator of vitamin D status, were measured using routine laboratory techniques...
April 3, 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29610620/evaluation-of-maximum-bite-force-in-patients-with-complete-dentures
#20
Kujtim Shala, Arlinda Tmava-Dragusha, Linda Dula, Teuta Pustina-Krasniqi, Teuta Bicaj, Enis Ahmedi, Zana Lila
OBJECTIVE: This study aimed to evaluate maximum bite forces (mBF) in dominant (DS) and non-dominant sides (NDS) at certain time periods after the insertion of new complete dentures based on prior experience and gender. MATERIALS AND METHODS: A total of 88 patients, complete denture wearers (CDWs), were examined. The maximum bite force at the intercuspal position between the first molars in 3 seconds was registered and recorded with piezoelectric gnathodynamometer...
March 15, 2018: Open Access Macedonian Journal of Medical Sciences
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