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JOURNAL ARTICLE
Nathan Trometer, Jérémy Pecourneau, Liwen Feng, José A Navarro-Huerta, Danielle Lazarin-Bidóia, Sueli de Oliveira Silva Lautenschlager, Louis Maes, Amanda Fortes Francisco, John M Kelly, Brigitte Meunier, Monica Cal, Pascal Mäser, Marcel Kaiser, Elisabeth Davioud-Charvet
Chagas disease, or American trypanosomiasis, is a neglected tropical disease which is a top priority target of the World Health Organization. The disease, endemic mainly in Latin America, is caused by the protozoan Trypanosoma cruzi and has spread around the globe due to human migration. There are multiple transmission routes, including vectorial, congenital, oral, and iatrogenic. Less than 1% of patients have access to treatment, relying on two old redox-active drugs that show poor pharmacokinetics and severe adverse effects...
April 12, 2024: ACS Infectious Diseases
#2
JOURNAL ARTICLE
Ethan Moitra, Toni M Amaral, Madeline B Benz, Simranjeet Cambow, A Rani Elwy, Zachary J Kunicki, Zhengduo Lu, Neil S Rafferty, Ana Rabasco, Rita Rossi, Heather T Schatten, Brandon A Gaudiano
BACKGROUND: The transition from acute (e.g., psychiatric hospitalization) to outpatient care is associated with increased risk for rehospitalization, treatment disengagement, and suicide among people with serious mental illness (SMI). Mobile interventions (i.e., mHealth) have the potential to increase monitoring and improve coping post-acute care for this population. This protocol paper describes a Hybrid Type 1 effectiveness-implementation study, in which a randomized controlled trial will be conducted to determine the effectiveness of a multi-component mHealth intervention (tFOCUS) for improving outcomes for adults with SMI transitioning from acute to outpatient care...
February 29, 2024: Contemporary Clinical Trials
#3
JOURNAL ARTICLE
Nohaila Rharmili, Omar Abdellaoui, Fouad Ouazzani Chahdi, Joel T Mague, Tuncer Hökelek, Ahmed Mazzah, Youssef Kandri Rodi, Nada Kheira Sebbar
The in-do-line portion of the title mol-ecule, C16 H13 NO2 , is planar. In the crystal, a layer structure is generated by C-H⋯O hydrogen bonds and C-H⋯π(ring), π-stacking and C=O⋯π(ring) inter-actions. The Hirshfeld surface analysis of the crystal structure indicates that the most important contributions for the crystal packing are from H⋯H (43.0%), H⋯C/C⋯H (25.0%) and H⋯O/O⋯H (22.8%) inter-actions. Hydrogen bonding and van der Waals inter-actions are the dominant inter-actions in the crystal packing...
February 1, 2024: Acta Crystallographica. Section E, Crystallographic Communications
#4
JOURNAL ARTICLE
Mira Sandersfeld, Maike Büttner-Herold, Fulvia Ferrazzi, Kerstin Amann, Kerstin Benz, Christoph Daniel
BACKGROUND: Macrophages play an important role in the pathogenesis of lupus nephritis (LN), but less is known about macrophage subtypes in pediatric LN. Here we compared renal inflammation in LN with other inflammatory pediatric kidney diseases and assessed whether inflammation correlates with clinical parameters. METHODS: Using immunofluorescence microscopy, we analyzed renal biopsies from 20 pediatric patients with lupus nephritis (ISN/RPS classes II-V) and pediatric controls with other inflammatory kidney diseases for infiltration with M1-like (CD68 + /CD206 - , CD68 + /CD163 -), M2a-like (CD206 + /CD68 +), and M2c-like macrophages (CD163 + /CD68 +) as well as CD3 + T-cells, CD20 + B-cells, and MPO + neutrophilic granulocytes...
February 8, 2024: Arthritis Research & Therapy
#5
REVIEW
Courtney B Lagarde, Joachim Kavalakatt, Megan C Benz, Mackenzie L Hawes, Carter A Arbogast, Nicole M Cullen, Emily C McConnell, Caroline Rinderle, Katherine L Hebert, Maninder Khosla, Jorge A Belgodere, Van T Hoang, Bridgette M Collins-Burow, Bruce A Bunnell, Matthew E Burow, Suresh K Alahari
Both breast cancer and obesity can regulate epigenetic changes or be regulated by epigenetic changes. Due to the well-established link between obesity and an increased risk of developing breast cancer, understanding how obesity-mediated epigenetic changes affect breast cancer pathogenesis is critical. Researchers have described how obesity and breast cancer modulate the epigenome individually and synergistically. In this review, the epigenetic alterations that occur in obesity, including DNA methylation, histone, and chromatin modification, accelerated epigenetic age, carcinogenesis, metastasis, and tumor microenvironment modulation, are discussed...
February 3, 2024: Oncogene
#6
JOURNAL ARTICLE
Marta C Cruz Cisneros, Elizabeth J Anderson, Brea K Hampton, Breantié Parotti, Sanjay Sarkar, Sharon Taft-Benz, Timothy A Bell, Matthew Blanchard, Jacob A Dillard, Kenneth H Dinnon, Pablo Hock, Sarah R Leist, Emily A Madden, Ginger D Shaw, Ande West, Ralph S Baric, Victoria K Baxter, Fernando Pardo-Manuel de Villena, Mark T Heise, Martin T Ferris
The COVID-19 pandemic led to the rapid and worldwide development of highly effective vaccines against SARS-CoV-2. However, there is significant individual-to-individual variation in vaccine efficacy due to factors including viral variants, host age, immune status, environmental and host genetic factors. Understanding those determinants driving this variation may inform the development of more broadly protective vaccine strategies. While host genetic factors are known to impact vaccine efficacy for respiratory pathogens such as influenza and tuberculosis, the impact of host genetic variation on vaccine efficacy against COVID-19 is not well understood...
January 20, 2024: Vaccines
#7
JOURNAL ARTICLE
Paul M Dahlke, Christian Benzing, Georg Lurje, Thomas Malinka, Nathanael Raschzok, Can Kamali, Safak Gül-Klein, Wenzel Schöning, Karl H Hillebrandt, Johann Pratschke, Jens Neudecker, Felix Krenzien
BACKGROUND: Adherence to enhanced recovery after surgery (ERAS) protocols is crucial for successful liver surgery. The aim of this study was to assess the impact of minimally invasive liver surgery complexity on adherence after implementing an ERAS protocol. METHODS: Between July 2018 and August 2021, a prospective observational study involving minimally invasive liver surgery patients was conducted. Perioperative treatment followed ERAS guidelines and was recorded in the ERAS interactive audit system...
January 3, 2024: BJS Open
#8
B E Morgado, B Sicardy, F Braga-Ribas, J L Ortiz, H Salo, F Vachier, J Desmars, C L Pereira, P Santos-Sanz, R Sfair, T de Santana, M Assafin, R Vieira-Martins, A R Gomes-Júnior, G Margoti, V S Dhillon, E Fernández-Valenzuela, J Broughton, J Bradshaw, R Langersek, G Benedetti-Rossi, D Souami, B J Holler, M Kretlow, R C Boufleur, J I B Camargo, R Duffard, W Beisker, N Morales, J Lecacheux, F L Rommel, D Herald, W Benz, E Jehin, F Jankowsky, T R Marsh, S P Littlefair, G Bruno, I Pagano, A Brandeker, A Collier-Cameron, H G Florén, N Hara, G Olofsson, T G Wilson, Z Benkhaldoun, R Busuttil, A Burdanov, M Ferrais, D Gault, M Gillon, W Hanna, S Kerr, U Kolb, P Nosworthy, D Sebastian, C Snodgrass, J P Teng, J de Wit
No abstract text is available yet for this article.
January 16, 2024: Nature
#9
JOURNAL ARTICLE
Yesh Datar, Olivier F Clerc, Sarah A M Cuddy, Sirwoo Kim, Alexandra Taylor, Jocelyn Canseco Neri, Dominik C Benz, Giada Bianchi, Andrew J Yee, Vaishali Sanchorawala, Frederick L Ruberg, Heather Landau, Ronglih Liao, Marie Foley Kijewski, Michael Jerosch-Herold, Raymond Y Kwong, Marcelo F Di Carli, Rodney H Falk, Sharmila Dorbala
AIMS: In systemic light-chain (AL) amyloidosis, quantification of right ventricular (RV) amyloid burden has been limited and the pathogenesis of RV dysfunction is poorly understood. Using 18F-florbetapir positron emission tomography/computed tomography (PET/CT), we aimed to quantify RV amyloid, correlate RV amyloid with RV structure and function, determine the independent contributions of RV, left ventricular (LV) and lung amyloid to RV function, and to associate RV amyloid with major adverse cardiac events (MACE: death, heart failure hospitalization, cardiac transplantation)...
January 9, 2024: European Heart Journal Cardiovascular Imaging
#10
JOURNAL ARTICLE
S Anwer, S Nussbaum, N E Winkler, D C Benz, D Zuercher, T G Donati, G Tsiourantani, V Wilzeck, J Michel, A M Kasel, F C Tanner
INTRODUCTION: Echocardiography is used for assessment of patients after transcatheter aortic valve implantation (TAVI). Global work index (GWI) integrates LV deformation throughout the cardiac cycle and LV afterload and may be advantageous for long-term follow-up. METHODS: We analysed 144 patients with severe aortic stenosis who underwent TAVI and echocardiography within two weeks afterwards. GE EchoPAC v2.6 was applied for determining LV ejection fraction, global longitudinal strain (GLS), stroke work (SW), cardiac power output (CPO), and GWI...
December 29, 2023: International Journal of Cardiology
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JOURNAL ARTICLE
R Luque, H P Osborn, A Leleu, E Pallé, A Bonfanti, O Barragán, T G Wilson, C Broeg, A Collier Cameron, M Lendl, P F L Maxted, Y Alibert, D Gandolfi, J-B Delisle, M J Hooton, J A Egger, G Nowak, M Lafarga, D Rapetti, J D Twicken, J C Morales, I Carleo, J Orell-Miquel, V Adibekyan, R Alonso, A Alqasim, P J Amado, D R Anderson, G Anglada-Escudé, T Bandy, T Bárczy, D Barrado Navascues, S C C Barros, W Baumjohann, D Bayliss, J L Bean, M Beck, T Beck, W Benz, N Billot, X Bonfils, L Borsato, A W Boyle, A Brandeker, E M Bryant, J Cabrera, S Carrazco-Gaxiola, D Charbonneau, S Charnoz, D R Ciardi, W D Cochran, K A Collins, I J M Crossfield, Sz Csizmadia, P E Cubillos, F Dai, M B Davies, H J Deeg, M Deleuil, A Deline, L Delrez, O D S Demangeon, B-O Demory, D Ehrenreich, A Erikson, E Esparza-Borges, B Falk, A Fortier, L Fossati, M Fridlund, A Fukui, J Garcia-Mejia, S Gill, M Gillon, E Goffo, Y Gómez Maqueo Chew, M Güdel, E W Guenther, M N Günther, A P Hatzes, Ch Helling, K M Hesse, S B Howell, S Hoyer, K Ikuta, K G Isaak, J M Jenkins, T Kagetani, L L Kiss, T Kodama, J Korth, K W F Lam, J Laskar, D W Latham, A Lecavelier des Etangs, J P D Leon, J H Livingston, D Magrin, R A Matson, E C Matthews, C Mordasini, M Mori, M Moyano, M Munari, F Murgas, N Narita, V Nascimbeni, G Olofsson, H L M Osborne, R Ottensamer, I Pagano, H Parviainen, G Peter, G Piotto, D Pollacco, D Queloz, S N Quinn, A Quirrenbach, R Ragazzoni, N Rando, F Ratti, H Rauer, S Redfield, I Ribas, G R Ricker, A Rudat, L Sabin, S Salmon, N C Santos, G Scandariato, N Schanche, J E Schlieder, S Seager, D Ségransan, A Shporer, A E Simon, A M S Smith, S G Sousa, M Stalport, Gy M Szabó, N Thomas, A Tuson, S Udry, A M Vanderburg, V Van Eylen, V Van Grootel, J Venturini, I Walter, N A Walton, N Watanabe, J N Winn, T Zingales
Planets with radii between that of the Earth and Neptune (hereafter referred to as 'sub-Neptunes') are found in close-in orbits around more than half of all Sun-like stars1,2 . However, their composition, formation and evolution remain poorly understood3 . The study of multiplanetary systems offers an opportunity to investigate the outcomes of planet formation and evolution while controlling for initial conditions and environment. Those in resonance (with their orbital periods related by a ratio of small integers) are particularly valuable because they imply a system architecture practically unchanged since its birth...
November 2023: Nature
#12
JOURNAL ARTICLE
A M Api, D Belsito, D Botelho, M Bruze, G A Burton, M A Cancellieri, H Chon, M L Dagli, M Date, W Dekant, C Deodhar, A D Fryer, L Jones, K Joshi, M Kumar, A Lapczynski, M Lavelle, I Lee, D C Liebler, H Moustakas, M Na, T M Penning, G Ritacco, J Romine, N Sadekar, T W Schultz, D Selechnik, F Siddiqi, I G Sipes, G Sullivan, Y Thakkar, Y Tokura
No abstract text is available yet for this article.
November 27, 2023: Food and Chemical Toxicology
#13
JOURNAL ARTICLE
Maja Wyczanska, Jana Rohling, Ursula Keller, Marcus R Benz, Carsten Kirschning, Bärbel Lange-Sperandio
Urinary tract obstruction during renal development leads to inflammation, tubular apoptosis, and interstitial fibrosis. Toll like receptors (TLRs) expressed on leukocytes, myofibroblasts and renal cells play a central role in acute inflammation. TLR2 is activated by endogenous danger signals in the kidney; its contribution to renal injury in early life is still a controversial topic. We analyzed TLR2 for a potential role in the neonatal mouse model of congenital obstructive nephropathy. Inborn obstructive nephropathies are a leading cause of end-stage kidney disease in children...
2023: PloS One
#14
Mark Heise, Jacob Dillard, Sharon Taft-Benz, Audrey Knight, Elizabeth Anderson, Katia Pressey, Breantié Parotti, Sabian Martinez, Jennifer Diaz, Sanjay Sarkar, Emily Madden, Gabriela De la Cruz, Lily Adams, Kenneth Dinnon Iii, Sarah Leist, David Martinez, Alexandra Schaefer, John Powers, Boyd Yount, Izabella Castillo, Noah Morales, Jane Burdick, Mia Katrina Evangelista, Lauren Ralph, Nicholas Pankow, Colton Linnertz, Prem Lakshmanane, Stephanie Montgomery, Martin Ferris, Ralph Baric, Victoria Baxter
Inactivated whole virus SARS-CoV-2 vaccines adjuvanted with aluminum hydroxide (Alum) are among the most widely used COVID-19 vaccines globally and have been critical to the COVID-19 pandemic response. Although these vaccines are protective against homologous virus infection in healthy recipients, the emergence of novel SARS-CoV-2 variants and the presence of large zoonotic reservoirs provide significant opportunities for vaccine breakthrough, which raises the risk of adverse outcomes including vaccine-associated enhanced respiratory disease (VAERD)...
October 27, 2023: Research Square
#15
JOURNAL ARTICLE
2-[4-(2-Chloro-benz-yl)-3-methyl-6-oxo-1,6-di-hydro-pyridazin-1-yl]- N -(4-fluoro-phen-yl)acetamide.
Hamza Assila, Issam Ameziane El Hassani, Abderrazzak El Moutaouakil Ala Allah, Abdulsalam Alsubari, Joel T Mague, Youssef Ramli, MHammed Ansar
The conformation of the title mol-ecule, C20 H17 ClFN3 O2 , is partly determined by an intra-molecular C-H⋯O hydrogen bond, which leads to a dihedral angle of 14.7 (4)° between the fluoro-benzene ring and the acetamide group. The 2-chloro-benzyl group is rotationally disordered over two orientations in a 0.656 (2): 0.344 (2) ratio. In the crystal, a layered structure is formed by N-H⋯O, C-H⋯O and C-H⋯F hydrogen bonds plus slipped π-π stacking inter-actions...
October 2023: IUCrData
#16
JOURNAL ARTICLE
Sita Arjune, Simon Oehm, Polina Todorova, Ron T Gansevoort, Stephan J L Bakker, Florian Erger, Thomas Benzing, Volker Burst, Franziska Grundmann, Philipp Antczak, Roman-Ulrich Müller
BACKGROUND: The identification of new biomarkers in autosomal-dominant polycystic kidney disease (ADPKD) is crucial to improve and simplify prognostic assessment as a basis for patient selection for targeted therapies. Post hoc analyses of the TEMPO 3:4 study indicated that copeptin could be one of those biomarkers. METHODS: Copeptin was tested in serum samples from patients of the AD(H)PKD study. Serum copeptin levels were measured using a time-resolved amplified cryptate emission (TRACE)-based assay...
November 2023: Clinical Kidney Journal
#17
Olivier F Clerc, Sarah A M Cuddy, Michael Jerosch-Herold, Dominik C Benz, Ethan Katznelson, Jocelyn Canseco Neri, Alexandra Taylor, Marie Foley Kijewski, Giada Bianchi, Frederick L Ruberg, Marcelo F Di Carli, Ronglih Liao, Raymond Y Kwong, Rodney H Falk, Sharmila Dorbala
AIMS: In systemic light-chain (AL) amyloidosis, cardiac involvement portends poor prognosis. Using myocardial characteristics on magnetic resonance imaging (MRI), this study aimed to detect early myocardial alterations, to analyze temporal changes with plasma cell therapy, and to predict risk of major adverse cardiac events (MACE) in AL amyloidosis. METHODS AND RESULTS: Participants with recently diagnosed AL amyloidosis were prospectively enrolled. Presence of AL cardiomyopathy (AL-CMP vs...
October 5, 2023: medRxiv
#18
JOURNAL ARTICLE
Tora Rydtun Haug, Mai-Britt Worm Ørntoft, Danilo Miskovic, Lene Hjerrild Iversen, Søren Paaske Johnsen, Jan Brink Valentin, Marcos Gómez Ruiz, Stefan Benz, Kristian Eeg Storli, Adam T Stearns, Anders Husted Madsen
AIM: The complete mesocolic excision competency assessment tool (CMECAT) is a novel tool designed to assess technical skills in minimally invasive complete mesocolic excision (CME) surgery. The aim of this study was to assess construct validity and reliability of CMECAT in a clinical context. METHOD: Colorectal surgeons were asked to submit video recorded laparoscopic CME resections for independent assessment of their technical abilities. The videos were grouped by surgeons' training level, and four established CME experts were recruited as CMECAT assessors...
September 30, 2023: Colorectal Disease
#19
JOURNAL ARTICLE
Elizabeth Benz, Lies Lahousse, Johnmary T Arinze, Sara Wijnant, Maria de Ridder, Fernando Rivadeneira, Guy Brusselle, Bruno H Stricker
BACKGROUND: Sarcopenia is characterised by two major phenotypic components: low handgrip strength (HGS) and appendicular skeletal muscle index (ASMI). Oral corticosteroid (OCS) use is an important medication for acute respiratory exacerbations in patients with COPD and asthma. However, the association of OCS and sarcopenia components in older people is largely unexplored. The aim of this study was to examine the association between OCS use and HGS or ASMI in the general population and explore interactions with chronic airway diseases...
September 2023: ERJ Open Research
#20
Olivier F Clerc, Yesh Datar, Sarah Am Cuddy, Giada Bianchi, Alexandra Taylor, Dominik C Benz, Matthew Robertson, Marie Foley Kijewski, Michael Jerosch-Herold, Raymond Y Kwong, Frederick L Ruberg, Ronglih Liao, Marcelo F Di Carli, Rodney H Falk, Sharmila Dorbala
BACKGROUND: Myocardial immunoglobulin light-chain (AL) amyloid deposits trigger heart failure, cardiomyocyte stretch and myocardial injury, leading to adverse cardiac outcomes. Positron emission tomography/computed tomography (PET/CT) with 18 F-florbetapir, a novel amyloid-targeting radiotracer, can quantify left ventricular (LV) amyloid burden, but its prognostic value is not known. Therefore, we aimed to evaluate the prognostic value of LV amyloid burden quantified by 18 F-florbetapir PET/CT and to identify mechanistic pathways mediating its association with outcomes...
September 14, 2023: medRxiv
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