keyword
MENU ▼
Read by QxMD icon Read
search

Benzing t

keyword
https://www.readbyqxmd.com/read/29765730/synthesis-and-structure-of-an-aryl-tellurenium-ii-cation-4-tert-butyl-2-6-bis-1-pentyl-1-h-benz-imidazol-2-yl-%C3%AE%C2%BA-n-3-phenyl-%C3%AE%C2%BA-c-1-tellurium-ii-1-4-dioxane-tri-iodido-mercurate-ii
#1
Varsha Rani, Harkesh B Singh, Ray J Butcher
In the title salt, (C34 H41 N4 Te)[HgI3 (C4 H8 O2 )], the aryl-tellurenium [C34 H41 N4 Te]+ cations and [HgI3 (dioxane)]- anions are linked by a short inter-action between the Te atom and one of the I-atom donors of the anion, as well as through weak C-H⋯I inter-actions. The geometry around the Te atom is T-shaped with the coordination comprising a C atom of the central aromatic ring and two N atom donors of the benzimidazolyl moiety. The Te-N bond lengths are almost equal [2.232 (3) and 2.244 (3) Å], while the Te-C bond length is 2...
March 1, 2018: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/29765728/different-mol-ecular-conformations-in-the-crystal-structures-of-three-5-nitro-imidazolyl-derivatives
#2
Luis F B Osorio, Samir A Carvalho, Edson F da Silva, Carlos A M Fraga, Solange M S V Wardell, Bruce F Milne, James L Wardell, William T A Harrison
The crystal structures of ( E )-1-methyl-5-nitro-1 H -imidazole-2-carbaldehyde O -benzyl-oxime, C12 H12 N4 O3 , (I), ( E )-1-methyl-5-nitro-1 H -imidazole-2-carb-alde-hyde O -(4-fluoro-benz-yl) oxime, C12 H11 FN4 O3 , (II), and ( E )-1-methyl-5-nitro-1 H -imidazole-2-carbaldehyde O -(4-bromo-benz-yl) oxime, C12 H11 BrN4 O3 , (III), are described. The dihedral angle between the ring systems in (I) is 49.66 (5)° and the linking Nm -C-C=N (m = methyl-ated) bond shows an anti conformation [torsion angle = 175...
March 1, 2018: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/29694247/protein-half-life-determines-expression-of-proteostatic-networks-in-podocyte-differentiation
#3
Christina B Schroeter, Sybille Koehler, Martin Kann, Bernhard Schermer, Thomas Benzing, Paul T Brinkkoetter, Markus M Rinschen
Podocytes are highly specialized, epithelial, postmitotic cells, which maintain the renal filtration barrier. When adapting to considerable metabolic and mechanical stress, podocytes need to accurately maintain their proteome. Immortalized podocyte cell lines are a widely used model for studying podocyte biology in health and disease in vitro. In this study, we performed a comprehensive proteomic analysis of the cultured human podocyte proteome in both proliferative and differentiated conditions at a depth of >7000 proteins...
April 25, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29617660/genomic-pathway-network-and-immunologic-features-distinguishing-squamous-carcinomas
#4
Joshua D Campbell, Christina Yau, Reanne Bowlby, Yuexin Liu, Kevin Brennan, Huihui Fan, Alison M Taylor, Chen Wang, Vonn Walter, Rehan Akbani, Lauren Averett Byers, Chad J Creighton, Cristian Coarfa, Juliann Shih, Andrew D Cherniack, Olivier Gevaert, Marcos Prunello, Hui Shen, Pavana Anur, Jianhong Chen, Hui Cheng, D Neil Hayes, Susan Bullman, Chandra Sekhar Pedamallu, Akinyemi I Ojesina, Sara Sadeghi, Karen L Mungall, A Gordon Robertson, Christopher Benz, Andre Schultz, Rupa S Kanchi, Carl M Gay, Apurva Hegde, Lixia Diao, Jing Wang, Wencai Ma, Pavel Sumazin, Hua-Sheng Chiu, Ting-Wen Chen, Preethi Gunaratne, Larry Donehower, Janet S Rader, Rosemary Zuna, Hikmat Al-Ahmadie, Alexander J Lazar, Elsa R Flores, Kenneth Y Tsai, Jane H Zhou, Anil K Rustgi, Esther Drill, Ronglei Shen, Christopher K Wong, Joshua M Stuart, Peter W Laird, Katherine A Hoadley, John N Weinstein, Myron Peto, Curtis R Pickering, Zhong Chen, Carter Van Waes
This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with smoking and/or human papillomavirus (HPV). SCCs harbor 3q, 5p, and other recurrent chromosomal copy-number alterations (CNAs), DNA mutations, and/or aberrant methylation of genes and microRNAs, which are correlated with the expression of multi-gene programs linked to squamous cell stemness, epithelial-to-mesenchymal differentiation, growth, genomic integrity, oxidative damage, death, and inflammation...
April 3, 2018: Cell Reports
https://www.readbyqxmd.com/read/29616745/in-situ-analysis-of-mast-cells-and-dendritic-cells-in-coronary-atherosclerosis-in-chronic-kidney-disease-ckd
#5
D L Wachter, D Neureiter, V Câmpean, K F Hilgers, M Büttner-Herold, C Daniel, K Benz, K Amann
AIMS: Mast cells (MC) and dendritic cells (DC) have immune modulatory function and can influence T-cell activity. Both cell types have been found in atherosclerotic plaques and are thought to play an important role for plaque stability. Compared to matched segments of the non-renal population, patients with chronic kidney disease (CKD) show a more pronounced and more aggressive course of atherosclerosis with higher plaque calcification and significantly higher complications rates. It was the aim of this study to analyze the number and localization of MCs and DCs, macrophages, T- and B-cells as well as the expression of markers of inflammation such as CRP and NFκB in calcified and non-calcified atherosclerotic plaques of patients with CKD and control patients...
April 4, 2018: Histology and Histopathology
https://www.readbyqxmd.com/read/29590750/repurposing-a-library-of-human-cathepsin-l-ligands-identification-of-macrocyclic-lactams-as-potent-rhodesain-and-trypanosoma-brucei-inhibitors
#6
Maude Giroud, Uwe Dietzel, Lilli Anselm, David Banner, Andreas Kuglstatter, Jörg Benz, Jean-Baptiste Blanc, Delphine Gaufreteau, Haixia Liu, Xianfeng Lin, August Stich, Bernd Kuhn, Franz Schuler, Marcel Kaiser, Reto Brun, Tanja Schirmeister, Caroline Kisker, François Diederich, Wolfgang Haap
Rhodesain (RD) is a parasitic, human cathepsin L (hCatL) -like cysteine protease produced by Trypanosoma brucei (T. b.) species and a potential drug target for the treatment of human African trypanosomiasis (HAT). A library of hCatL inhibitors was screened, and macrocyclic lactams were identified as potent RD inhibitors (Ki < 10 nM), preventing the cell-growth of T. b. rhodesiense (IC50 < 400 nM). SARs addressing the S2 and S3 pockets of RD were established. Three cocrystal structures with RD revealed a non-covalent binding mode of this ligand class, due to oxidation of the catalytic Cys25 to a sulfenic acid (Cys-SOH) during crystallization...
March 29, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29470729/retromesenteric-course-of-the-middle-colic-artery-challenges-and-pitfalls-in-d3-right-colectomy-for-cancer
#7
Bojan V Stimec, Bjarte T Andersen, Stefan R Benz, Jean H D Fasel, Knut M Augestad, Dejan Ignjatovic
BACKGROUND: The middle colic artery (MCA) is of crucial importance in abdominal surgery, for laparoscopic or open right and transverse colectomies. Against this background, a high number of reports concerning anatomical variations of the MCA have been published intended to contribute to the improvement of operative techniques for the treatment of colon cancer. Despite this extensive literature, briefly reviewed in the present paper, a course of the MCA posterior to the superior mesenteric vein, called a retromesenteric trajectory, has been related to only once, to the best of our knowledge...
February 22, 2018: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29346988/liquid-part-of-the-phase-diagram-and-percolation-line-for-two-dimensional-mercedes-benz-water
#8
T Urbic
Monte Carlo simulations and Wertheim's thermodynamic perturbation theory (TPT) are used to predict the phase diagram and percolation curve for the simple two-dimensional Mercedes-Benz (MB) model of water. The MB model of water is quite popular for explaining water properties, but the phase diagram has not been reported till now. In the MB model, water molecules are modeled as two-dimensional Lennard-Jones disks, with three orientation-dependent hydrogen-bonding arms, arranged as in the MB logo. The liquid part of the phase space is explored using grand canonical Monte Carlo simulations and two versions of Wertheim's TPT for associative fluids, which have been used before to predict the properties of the simple MB model...
September 2017: Physical Review. E
https://www.readbyqxmd.com/read/29316429/integrative-analysis-identifies-four-molecular-and-clinical-subsets-in-uveal-melanoma
#9
A Gordon Robertson, Juliann Shih, Christina Yau, Ewan A Gibb, Junna Oba, Karen L Mungall, Julian M Hess, Vladislav Uzunangelov, Vonn Walter, Ludmila Danilova, Tara M Lichtenberg, Melanie Kucherlapati, Patrick K Kimes, Ming Tang, Alexander Penson, Ozgun Babur, Rehan Akbani, Christopher A Bristow, Katherine A Hoadley, Lisa Iype, Matthew T Chang, Andrew D Cherniack, Christopher Benz, Gordon B Mills, Roel G W Verhaak, Klaus G Griewank, Ina Felau, Jean C Zenklusen, Jeffrey E Gershenwald, Lynn Schoenfield, Alexander J Lazar, Mohamed H Abdel-Rahman, Sergio Roman-Roman, Marc-Henri Stern, Colleen M Cebulla, Michelle D Williams, Martine J Jager, Sarah E Coupland, Bita Esmaeli, Cyriac Kandoth, Scott E Woodman
No abstract text is available yet for this article.
January 8, 2018: Cancer Cell
https://www.readbyqxmd.com/read/29128897/speed-of-processing-training-in-middle-aged-and-older-breast-cancer-survivors-soar-results-of-a-randomized-controlled-pilot
#10
Karen Meneses, Rachel Benz, Jennifer R Bail, Jacqueline B Vo, Kristen Triebel, Pariya Fazeli, Jennifer Frank, David E Vance
PURPOSE: Cognitive changes are common among breast cancer survivors. There is limited evidence to guide management of cognitive changes. This randomized controlled pilot evaluated the preliminary efficacy of a speed of processing (SOP) training among middle-aged and older breast cancer survivors. METHODS: Sixty breast cancer survivors  with self-reported cognitive changes were recruited to the SOAR study. Participants were randomized to either a home-based SOP training (n = 30) or no-contact control group (n = 30)...
February 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29119000/comparing-the-physiochemical-parameters-of-three-celluloses-reveals-new-insights-into-substrate-suitability-for-fungal-enzyme-production
#11
Lara Hassan, Manfred J Reppke, Nils Thieme, Steffen A Schweizer, Carsten W Mueller, J Philipp Benz
Background: The industrial applications of cellulases are mostly limited by the costs associated with their production. Optimized production pathways are therefore desirable. Based on their enzyme inducing capacity, celluloses are commonly used in fermentation media. However, the influence of their physiochemical characteristics on the production process is not well understood. In this study, we examined how physical, structural and chemical properties of celluloses influence cellulase and hemicellulase production in an industrially-optimized and a non-engineered filamentous fungus: Trichoderma reesei RUT-C30 and Neurospora crassa ...
2017: Fungal Biology and Biotechnology
https://www.readbyqxmd.com/read/29043842/the-protective-and-immunomodulatory-effects-of-fucoidan-against-7-12-dimethyl-benz-a-anthracene-induced-experimental-mammary-carcinogenesis-through-the-pd1-pdl1-signaling-pathway-in-rats
#12
Meilan Xue, Hui Liang, Qingjuan Tang, Chuanxing Xue, Xinjia He, Li Zhang, Zheng Zhang, Zhengyan Liang, Kang Bian, Lichen Zhang, Zhuxin Li
Fucoidan is a sulfated polysaccharide that is extracted from brown algae seaweed. This study was designed to evaluate the protective and immunomodulatory effects of dietary fucoidan on 7,12-dimethyl benz[a]anthracene (DMBA)-induced experimental mammary carcinogenesis in rats. Sixty Sprague-Dawley rats were randomly assigned to four equal groups: the control group (control group), the cancer model group (model group), and the F1 and F2 groups, which were fed fucoidan at concentrations of 200 and 400 mg/kg·body weight, respectively...
November 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/29016221/apoptotic-and-immunosuppressive-effects-of-turmeric-paste-on-7-12-di-methyl-benz-a-anthracene-induced-skin-tumor-model-of-wistar-rat
#13
R S Rajmani, Prafull Singh, Lakshya Veer Singh
Dietary components with potent anticancerous property are gaining attention as therapeutic agents due to low cost of therapy and minimal toxic effects. Turmeric is one such miracle spices of Indian and South Asian recipes with multiple medicinal properties. The anticarcinogenic properties of its active compound curcumin have been studied in detail. However, studies on the medicinal properties of crude turmeric used as dietary agents are lacking. Therefore, in this study we investigated the effects of dietary and topical crude turmeric paste on DMBA induced skin tumor of male Wistar rats...
November 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28947916/network-reconstruction-and-systems-analysis-of-plant-cell-wall-deconstruction-by-neurospora-crassa
#14
Areejit Samal, James P Craig, Samuel T Coradetti, J Philipp Benz, James A Eddy, Nathan D Price, N Louise Glass
BACKGROUND: Plant biomass degradation by fungal-derived enzymes is rapidly expanding in economic importance as a clean and efficient source for biofuels. The ability to rationally engineer filamentous fungi would facilitate biotechnological applications for degradation of plant cell wall polysaccharides. However, incomplete knowledge of biomolecular networks responsible for plant cell wall deconstruction impedes experimental efforts in this direction. RESULTS: To expand this knowledge base, a detailed network of reactions important for deconstruction of plant cell wall polysaccharides into simple sugars was constructed for the filamentous fungus Neurospora crassa...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/28877958/proline-dependent-and-basophilic-kinases-phosphorylate-human-trpc6-at-serine-14-to-control-channel-activity-through-increased-membrane-expression
#15
Henning Hagmann, Nicole Mangold, Markus M Rinschen, Tim Koenig, Karl Kunzelmann, Bernhard Schermer, Thomas Benzing, Paul T Brinkkoetter
Signaling via the transient receptor potential (TRP) ion channel C6 plays a pivotal role in hereditary and sporadic glomerular kidney disease. Several studies have identified gain-of-function mutations of TRPC6 and report induced expression and enhanced channel activity of TRPC6 in association with glomerular diseases. Interfering with TRPC6 activity may open novel therapeutic pathways. TRPC6 channel activity is controlled by protein expression and stability as well as intracellular trafficking. Identification of regulatory phosphorylation sites in TRPC6 and corresponding protein kinases is essential to understand the regulation of TRPC6 activity and may result in future therapeutic strategies...
January 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28822014/functional-igf1r-variant-predicts-breast-cancer-risk-in-women-with-preeclampsia-in-california-teachers-study
#16
Mark J Powell, Julie Von Behren, Susan Neuhausen, Peggy Reynolds, Christopher C Benz
PURPOSE: Hypertension in pregnancy has been associated with decreased future risk of breast cancer in many but not all studies. In the Marin Women's Study, pregnancy-induced hypertension was shown to interact with the T allele of a functional IGF1R gene variant, rs2016347, to result in lower breast density, as well as decreased breast cancer risk. Our objective was to explore these findings in a larger sample of women from the California Teachers Study (CTS). METHODS: The CTS cohort consists of over 130,000 female educators...
October 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28810145/integrative-analysis-identifies-four-molecular-and-clinical-subsets-in-uveal-melanoma
#17
A Gordon Robertson, Juliann Shih, Christina Yau, Ewan A Gibb, Junna Oba, Karen L Mungall, Julian M Hess, Vladislav Uzunangelov, Vonn Walter, Ludmila Danilova, Tara M Lichtenberg, Melanie Kucherlapati, Patrick K Kimes, Ming Tang, Alexander Penson, Ozgun Babur, Rehan Akbani, Christopher A Bristow, Katherine A Hoadley, Lisa Iype, Matthew T Chang, Andrew D Cherniack, Christopher Benz, Gordon B Mills, Roel G W Verhaak, Klaus G Griewank, Ina Felau, Jean C Zenklusen, Jeffrey E Gershenwald, Lynn Schoenfield, Alexander J Lazar, Mohamed H Abdel-Rahman, Sergio Roman-Roman, Marc-Henri Stern, Colleen M Cebulla, Michelle D Williams, Martine J Jager, Sarah E Coupland, Bita Esmaeli, Cyriac Kandoth, Scott E Woodman
Comprehensive multiplatform analysis of 80 uveal melanomas (UM) identifies four molecularly distinct, clinically relevant subtypes: two associated with poor-prognosis monosomy 3 (M3) and two with better-prognosis disomy 3 (D3). We show that BAP1 loss follows M3 occurrence and correlates with a global DNA methylation state that is distinct from D3-UM. Poor-prognosis M3-UM divide into subsets with divergent genomic aberrations, transcriptional features, and clinical outcomes. We report change-of-function SRSF2 mutations...
August 14, 2017: Cancer Cell
https://www.readbyqxmd.com/read/28754558/magnetic-resonance-t2-mapping-and-diffusion-weighted-imaging-for-early-detection-of-cystogenesis-and-response-to-therapy-in-a-mouse-model-of-polycystic-kidney-disease
#18
Mareike Franke, Bettina Baeßler, Jan Vechtel, Claudia Dafinger, Martin Höhne, Lori Borgal, Heike Göbel, Friederike Koerber, David Maintz, Thomas Benzing, Bernhard Schermer, Thorsten Persigehl
Polycystic kidney disease (PKD) is among the leading causes of end-stage renal disease. Increasing evidence exists that molecular therapeutic strategies targeted to cyst formation and growth might be more efficacious in early disease stages, highlighting the growing need for sensitive biomarkers. Here we apply quantitative magnetic resonance imaging techniques of T2 mapping and diffusion-weighted imaging in the jck mouse model for PKD using a clinical 3.0 T scanner. We tested whether kidney T2 values and the apparent diffusion coefficient (ADC) are superior to anatomical imaging parameters in the detection of early cystogenesis, as shown on macro- and histopathology...
December 2017: Kidney International
https://www.readbyqxmd.com/read/28668433/scan-time-adapted-contrast-agent-injection-protocols-with-low-volume-for-low-tube-voltage-ct-angiography-an-in-vitro-study
#19
Matthias R Benz, Zsolt Szucs-Farkas, Johannes M Froehlich, Geraldine Stadelmann, Georg Bongartz, Luc Bouwman, Sebastian T Schindera
PURPOSE: The aims of this study were twofold. First, we investigated the extent of changes in arterial peak enhancement and changes in the duration of a diagnostic arterial enhancement when small amounts of CA volumes (≤30mL) were administered at varying tube voltages. Second, we investigated how to optimize CA injection protocols for CT-angiography with long scan times at various tube voltages to achieve optimal vascular enhancement at the lowest reasonable CA dose. MATERIALS AND METHODS: Measurements were performed with a custom-made dynamic flow phantom...
August 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28573548/redescription-of-tripaphylus-musteli-van-beneden-1851-copepoda-sphyriidae-and-the-relegation-of-paeon-wilson-1919-to-synonymy-with-tripaphylus-richiardi-in-anonymous-1878
#20
George W Benz, Geoffrey A Boxshall
Tripaphylus musteli (van Beneden, 1851) (Copepoda, Siphonostomatoida, Sphyriidae) is redescribed from an adult female collected from the branchial chamber of a starry smooth-hound, Mustelus asterias Cloquet (Carcharhiniformes, Triakidae), captured in the English Channel off Portland, UK. The new account of T. musteli is the first based on a complete adult female and highlighted the lack of a robust distinction separating Tripaphylus Richiardi, in Anonymous, 1878 and Paeon Wilson, 1919 prompting us to relegate Paeon to a junior subjective synonym of Tripaphylus...
July 2017: Systematic Parasitology
keyword
keyword
91540
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"