keyword
https://read.qxmd.com/read/38492742/-climate-and-environmental-crisis-impacts-on-women-s-health-what-specificities-what-can-be-done
#21
JOURNAL ARTICLE
Catherine Azoulay
OBJECTIVE: Pollution is one of the world's largest risk factors for disease and premature death. In Europe, it is responsible for approximately 20% of mortality. Chemicals exposure can occur by inhalation, ingestion or skin contact and begins in utero. Pollutants can be divided into three categories: endocrine disruptors (pesticides, PFAS, plastics, dioxins, etc.), heavy metals (cadmium, mercury and lead...) and nanomaterials. Climate change and air pollution are other main health threats...
March 14, 2024: Gynecologie, Obstetrique, Fertilite & Senologie
https://read.qxmd.com/read/38490142/a-functionalized-glass-fiber-as-the-adsorbent-for-efficient-analysis-of-endocrine-disruptors-in-aqueous-environments
#22
JOURNAL ARTICLE
Yingying Wang, Zhenyu Lu, Yayan Tong, Run Sun, Xue Liu, Na Chen, Mingxia Zhang, Yijun Zhang, Yuping Zhang
Estrogens and bisphenols are typical endocrine disruptors (EDs) that pose a potential hazard to the human body due to their widespread presence in aqueous environments. In this study, a β-cyclodextrin porous crosslinked polymer (β-CD-PCP) was prepared in-situ on a glass fiber surface by a nucleophilic substitution reaction. An effective and sensitive solid phase microextraction method using functionalized glass fiber with β-CD-PCP coating as the adsorbent was established for the detection of 11 EDs in a water environment...
March 11, 2024: Journal of Chromatography. A
https://read.qxmd.com/read/38489980/futuristic-advancements-in-phytoremediation-of-endocrine-disruptor-bisphenol-a-a-step-towards-sustainable-pollutant-degradation-for-rehabilitated-environment
#23
JOURNAL ARTICLE
Praveen Kumar Issac, Gokulam Ravindiran, Kadhirmathiyan Velumani, Arun Jayaseelan, Babett Greff, Ravi Mani, Soon Woong Chang, Balasubramani Ravindran, Mukesh Kumar Awasthi
Bisphenol A (BPA) accumulates in the environment at lethal concentrations because of its high production rate and utilization. BPA, originating from industrial effluent, plastic production, and consumer products, poses serious risks to both the environment and human health. The widespread aggregation of BPA leads to endocrine disruption, reactive oxygen species-mediated DNA damage, epigenetic modifications and carcinogenicity, which can disturb the normal homeostasis of the body. The living being in a population is subjected to BPA exposure via air, water and food...
March 14, 2024: Waste Management
https://read.qxmd.com/read/38488920/a-critical-and-comprehensive-review-of-the-current-status-of-17%C3%AE-estradiol-hormone-remediation-through-adsorption-technology
#24
REVIEW
Jordana Georgin, Dison Stracke Pfingsten Franco, Mohammad Saood Manzar, Lucas Meili, Noureddine El Messaoudi
Even at low concentrations, steroid hormones pose a significant threat to ecosystem health and are classified as micropollutants. Among these, 17β-estradiol (molecular formula: C18 H24 O2 ; pKa  = 10.46; Log Kow  = 4.01; solubility in water = 3.90 mg L-1 at 27 °C; molecular weight: 272.4 g mol-1 ) is extensively studied as an endocrine disruptor due to its release through natural pathways and widespread use in conventional medicine...
March 15, 2024: Environmental Science and Pollution Research International
https://read.qxmd.com/read/38479527/transgenerational-effects-of-triazole-fungicides-on-gene-expression-and-egg-compounds-in-non-exposed-offspring-a-case-study-using-red-legged-partridges-alectoris-rufa
#25
JOURNAL ARTICLE
Elena Fernández-Vizcaíno, Rafael Mateo, Isabel G Fernández de Mera, François Mougeot, Pablo R Camarero, Manuel E Ortiz-Santaliestra
Triazole fungicides are widely used to treat cereal seeds before sowing. Granivorous birds like the Red-legged Partridge (Alectoris rufa) have high exposure risk because they ingest treated seeds that remain on the field surface. As triazole fungicides can act as endocrine disruptors, affecting sterol synthesis and reproduction in birds several months after exposure, we hypothesized that these effects could also impact subsequent generations of exposed birds. To test this hypothesis, we exposed adult partridges (F0) to seeds treated at commercial doses with four different formulations containing triazoles as active ingredients (flutriafol, prothioconazole, tebuconazole, and a mixture of the latter two), simulating field exposure during late autumn sowing...
March 11, 2024: Science of the Total Environment
https://read.qxmd.com/read/38476946/editorial-recent-advances-in-bioremediation-of-emerging-contaminants-and-endocrine-disruptors
#26
EDITORIAL
Qian Sun, Takayuki Wada, Chien-Sen Liao
No abstract text is available yet for this article.
2024: Frontiers in Microbiology
https://read.qxmd.com/read/38473752/bisphenol-a-unveiling-its-role-in-glioma-progression-and-tumor-growth
#27
JOURNAL ARTICLE
Liang Niu, Juan Jia, Hu Yang, Shangyu Liu, Hongyu Wang, Yunji Yan, Qiao Li, Qiang Dong, He Zhang, Guoming Zhao, Junqiang Dai, Guoqiang Yuan, Yawen Pan
Gliomas represent the most common and lethal category of primary brain tumors. Bisphenol A (BPA), a widely recognized endocrine disruptor, has been implicated in the progression of cancer. Despite its established links to various cancers, the association between BPA and glioma progression remains to be clearly defined. This study aimed to shed light on the impact of BPA on glioma cell proliferation and overall tumor progression. Our results demonstrate that BPA significantly accelerates glioma cell proliferation in a time- and dose-dependent manner...
February 21, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38469564/characterization-of-flavonoids-with-potent-and-subtype-selective-actions-on-estrogen-receptors-alpha-and-beta
#28
JOURNAL ARTICLE
Michael J Bolt, Jessica Oceguera, Pankaj K Singh, Kazem Safari, Derek H Abbott, Kaley A Neugebauer, Maureen G Mancini, Daniel A Gorelick, Fabio Stossi, Michael A Mancini
The initial step in estrogen-regulated transcription is the binding of a ligand to its cognate receptors, named estrogen receptors (ERα and ERβ). Phytochemicals present in foods and environment can compete with endogenous hormones to alter physiological responses. We screened 224 flavonoids in our engineered biosensor ERα and ERβ PRL-array cell lines to characterize their activity on several steps of the estrogen signaling pathway. We identified 83 and 96 flavonoids that can activate ERα or ERβ, respectively...
March 15, 2024: IScience
https://read.qxmd.com/read/38469179/redox-mechanisms-of-environmental-toxicants-on-male-reproductive-function
#29
REVIEW
Tarique Hussain, Elsayed Metwally, Ghulam Murtaza, Dildar Hussain Kalhoro, Muhammad Ismail Chughtai, Bie Tan, Ali Dogan Omur, Shakeel Ahmed Tunio, Muhammad Shahzad Akbar, Muhammad Saleem Kalhoro
Humans and wildlife, including domesticated animals, are exposed to a myriad of environmental contaminants that are derived from various human activities, including agricultural, household, cosmetic, pharmaceutical, and industrial products. Excessive exposure to pesticides, heavy metals, and phthalates consequently causes the overproduction of reactive oxygen species. The equilibrium between reactive oxygen species and the antioxidant system is preserved to maintain cellular redox homeostasis. Mitochondria play a key role in cellular function and cell survival...
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38467088/relationship-of-bisphenol-a-substitutes-bisphenol-f-and-bisphenol-s-with-adiponectin-leptin-ratio-among-children-from-the-environment-and-development-of-children-cohort
#30
JOURNAL ARTICLE
Hye Jin Lee, Yun Jeong Lee, Youn-Hee Lim, Hwa Young Kim, Bung-Nyun Kim, Johanna Inhyang Kim, Yong Min Cho, Yun-Chul Hong, Choong Ho Shin, Young Ah Lee
BACKGROUND: Bisphenol A (BPA) is known as an obesogenic endocrine disruptor. Bisphenol S (BPS) and F (BPF) are substitutes that have recently replaced BPA. OBJECTIVES: To investigate the relationships of urinary bisphenols (BPA, BPS and BPF) with adiposity measurements (obesity, BMI z-score, and fat mass), serum adipokine levels (adiponectin and leptin), and adiponectin/leptin ratio (A/L ratio) in 6- and 8-year-old children. METHODS: A total of 561 children who participated in the Environment and Development of Children cohort (482 and 516 children visited at age 6 and 8, respectively) at Seoul National University Children's Hospital during 2015-2019 were included...
March 5, 2024: Environment International
https://read.qxmd.com/read/38466501/potential-application-of-2d-nano-layered-mxene-in-analysing-and-remediating-endocrine-disruptor-compounds-and-heavy-metals-in-water
#31
REVIEW
Muhammad Nur' Hafiz Rozaini, Kuan Shiong Khoo, Muhammad Amirul Aizat Mohd Abdah, Baranitharan Ethiraj, Mohammad Mahtab Alam, Aliya Fathima Anwar, Normawati M Yunus, Chin Seng Liew, Jun Wei Lim, Chii-Dong Ho, Woei-Yenn Tong
With the advancement of technologies and growth of the economy, it is inevitable that more complex processes are deployed, producing more heterogeneous wastewater that comes from biomedical, biochemical and various biotechnological industries. While the conventional way of wastewater treatment could effectively reduce the chemical oxygen demand, pH and turbidity of wastewater, trace pollutants, specifically the endocrine disruptor compounds (EDCs) that exist in µg L-1 or ng L-1 have further hardened the detection and removal of these biochemical pollutants...
March 11, 2024: Environmental Geochemistry and Health
https://read.qxmd.com/read/38465867/correction-to-developmental-exposure-to-hormone-mimicking-insect-growth-disruptors-alters-expression-of-endocrine-related-genes-in-worker-honey-bee-hymenoptera-apidae-brains-and-hypopharyngeal-glands
#32
https://read.qxmd.com/read/38462176/evaluating-the-impact-of-polycyclic-aromatic-hydrocarbon-bioaccumulation-in-adipose-tissue-of-obese-women
#33
JOURNAL ARTICLE
Sara Sousa, Paula Paíga, Diogo Pestana, Gil Faria, Cristina Delerue-Matos, Maria João Ramalhosa, Conceição Calhau, Valentina Fernandes Domingues
Polycyclic aromatic hydrocarbons (PAHs) are widespread across the environment and humans are unavoidably and constantly exposed to them. As lipophilic contaminants, these substances tend to accumulate in fatty tissues as adipose tissue and exposure to these endocrine disruptors has been associated with severe health hazards including prevalence and incidence of obesity. Previous studies have shown significantly higher concentrations of PAHs in adipose tissue compared to other human samples, such as urine and plasma, which are typically used for PAHs assessment...
March 8, 2024: Chemosphere
https://read.qxmd.com/read/38461993/phthalate-biomarkers-composition-in-relation-to-fatty-liver-evidence-from-epidemiologic-and-in-vivo-studies
#34
JOURNAL ARTICLE
Shucong Chen, Hang Liu, Yulian Sun, Shuxian Li, Yixuan Shi, Zhipeng Cheng, Hongkai Zhu, Hongwen Sun
Phthalates, classified as environmental endocrine disruptors, pose potential toxicity risks to human health. Metabolic dysfunction-associated fatty liver disease is one of the most widespread liver diseases globally. Compared to studies focusing on metabolic disorders in relation to pollutants exposure, the impact of individual factors such as fatty liver on the in vivo metabolism of pollutants is always overlooked. Therefore, this study measured concentrations and composition of phthalate monoesters (mPAEs) in human urine samples, particularly those from fatty liver patients...
March 8, 2024: Science of the Total Environment
https://read.qxmd.com/read/38461794/disruption-of-gonocyte-development-following-neonatal-exposure-to-di-2-ethylhexyl-phthalate
#35
JOURNAL ARTICLE
Estefanía Reyes-Cruz, Julio César Rojas-Castañeda, Daniel Adrian Landero-Huerta, Norma Hernández-Jardón, Rafael Reynoso-Robles, María de Lourdes Juárez-Mosqueda, Alfredo Medrano, Rosa María Vigueras-Villaseñor
Pre- and/or post-natal administrations of di(2-ethylhexyl) phthalate (DEHP) in experimental animals cause alterations in the spermatogenesis. However, the mechanism by which DEHP affects fertility is unknown and could be through alterations in the survival and differentiation of the gonocytes. The aim of the present study was to evaluate the effect of a single administration of DEHP in newborn mice on gonocytic proliferation, differentiation and survival and its long-term effects on seminiferous epithelium and sperm quality...
March 9, 2024: Reproductive Biology
https://read.qxmd.com/read/38460409/identification-of-endocrine-disrupting-chemicals-targeting-key-dcm-associated-genes-via-bioinformatics-and-machine-learning
#36
JOURNAL ARTICLE
Shu Li, Shuice Liu, Xuefei Sun, Liying Hao, Qinghua Gao
Dilated cardiomyopathy (DCM) is a primary cause of heart failure (HF), with the incidence of HF increasing consistently in recent years. DCM pathogenesis involves a combination of inherited predisposition and environmental factors. Endocrine-disrupting chemicals (EDCs) are exogenous chemicals that interfere with endogenous hormone action and are capable of targeting various organs, including the heart. However, the impact of these disruptors on heart disease through their effects on genes remains underexplored...
March 8, 2024: Ecotoxicology and Environmental Safety
https://read.qxmd.com/read/38458066/toxic-effects-of-triclosan-on-hepatic-and-intestinal-lipid-accumulation-in-zebrafish-via-regulation-of-m6a-rna-methylation
#37
JOURNAL ARTICLE
Jinyun Li, Lu Fang, Miaocui Xi, Anyu Ni, Qiuhui Qian, Zejun Wang, Huili Wang, Jin Yan
Triclosan (TCS), recognized as an endocrine disruptor, has raised significant concerns due to its widespread use and potential health risks. To explore the impact of TCS on lipid metabolism, both larval and adult zebrafish were subjected to acute and chronic exposure to TCS. Through analyzes of biochemical and physiological markers, as well as Oil Red O (ORO) and hematoxylin and eosin (H&E) staining, our investigation revealed that TCS exposure induced hepatic and intestinal lipid accumulation in larval and adult zebrafish, leading to structural damage and inflammatory responses in these tissues...
March 2, 2024: Aquatic Toxicology
https://read.qxmd.com/read/38448539/novel-biosensor-for-high-throughput-detection-of-progesterone-receptor-interacting-endocrine-disruptors
#38
JOURNAL ARTICLE
Diana A Stavreva, Lyuba Varticovski, Razi Raziuddin, Gianluca Pegoraro, R Louis Schiltz, Gordon L Hager
Progesterone receptor (PR)-interacting compounds in the environment are associated with serious health hazards. However, methods for their detection in environmental samples are cumbersome. We report a sensitive activity-based biosensor for rapid and reliable screening of progesterone receptor (PR)-interacting endocrine disrupting chemicals (EDCs). The biosensor is a cell line which expresses nuclear mCherry-NF1 and a green fluorescent protein (GFP)-tagged chimera of glucocorticoid receptor (GR) N terminus fused to the ligand binding domain (LBD) of PR (GFP-GR-PR)...
March 6, 2024: Scientific Reports
https://read.qxmd.com/read/38447467/fast-and-sustainable-planar-yeast-based-bioassay-for-endocrine-disruptors-in-complex-mixtures-start-of-cell-cultivation-to-result-within-one-day
#39
JOURNAL ARTICLE
Alisa Ronzheimer, Anne E Ringelmann, Gertrud E Morlock
High-performance thin-layer chromatography hyphenated with planar multiplex bioassays and high-resolution tandem mass spectrometry contributes to the non-target detection or even identification of active compounds in complex mixtures such as food, feed, cosmetics, commodities, and environmental samples. It can be used to discover previously unknown harmful or active substances in complex samples and to tentatively assign molecular formulas. This method is already faster than the commonly used in vitro assays along with liquid chromatographic separations, but overnight cell cultivation still prevents a planar bioassay from being performed within one day...
February 10, 2024: Talanta
https://read.qxmd.com/read/38446677/health-effects-of-fossil-fuel-derived-endocrine-disruptors
#40
REVIEW
Tracey J Woodruff
New England Journal of Medicine, Volume 390, Issue 10, Page 922-933, March 2024.
March 7, 2024: New England Journal of Medicine
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