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Endocrine disruptors

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https://www.readbyqxmd.com/read/28436414/daily-diet-containing-canned-products-significantly-increases-serum-concentrations-of-endocrine-disruptor-bisphenol-a-in-young-women
#1
Aleksandra Szybiak, Aleksandra Rutkowska, Kamila Wilczewska, Andrzej Wasik, Jacek Namieśnik, Dominik Rachoń
No abstract text is available yet for this article.
April 24, 2017: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/28431277/endocrine-disruption-by-environmental-gestagens-in-amphibians-a-short-review-supported-by-new-in%C3%A2-vitro-data-using-gonads-of-xenopus-laevis
#2
REVIEW
Andrea Ziková, Claudia Lorenz, Frauke Hoffmann, Wibke Kleiner, Ilka Lutz, Matthias Stöck, Werner Kloas
Endocrine disruption caused by various anthropogenic compounds is of persisting concern, especially for aquatic wildlife, because surface waters are the main sink of these so-called endocrine disruptors (ED). In the past, research focused on (anti)estrogenic, (anti)androgenic, and (anti)thyroidal substances, affecting primarily reproduction and development in vertebrates; however, other endocrine systems might be also targeted by ED. Environmental gestagens, including natural progestogens (e.g. progesterone (P4)) and synthetic progestins used for contraception, are supposed to affect vertebrate reproduction via progesterone receptors...
April 5, 2017: Chemosphere
https://www.readbyqxmd.com/read/28430968/sex-chromosome-dependent-differential-viability-of-human-spermatozoa-during-prolonged-incubation
#3
Young-Ah You, Woo-Sung Kwon, Md Saidur Rahman, Yoo-Jin Park, Young-Ju Kim, Myung-Geol Pang
STUDY QUESTION: Are there significant differences in the ability of X chromosome-bearing (X) spermatozoa and Y chromosome-bearing (Y) spermatozoa to survive incubation under stressful conditions? SUMMARY ANSWER: Y spermatozoa are more vulnerable to stress than their X counterparts depending on culture period and temperature, and show higher expression of apoptotic proteins. WHAT IS KNOWN ALREADY: The primary sex ratio is determined by there being an equal number of spermatozoa carrying X and Y chromosomes...
April 19, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28422034/endocrine-disruptors-and-prostate-cancer
#4
Eduardo Sénchez de Badajoz, José Maria Lage-Sánchez, Pilar Sánchez-Gallegos
OBJECTIVES: Although prostate cancer is probably the most frequent cancer in men, little is known about its etiology. Clear evidence exists about variations in the incidence of prostate cancer between populations living in different countries. These variations could be explained by differences in lifestyle and a possible association with a set of substances that are able to intervene in the origin of the disease. METHODS: The reason that lifestyle may be the cause of prostate cancer is related to endocrine disruptors...
April 2017: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/28414217/selection-of-group-specific-pae-binding-dna-aptamers-via-rational-designed-target-immobilization-and-applications-for-ultrasensitive-and-highly-selective-detection-of-paes
#5
Yu Han, Donglin Diao, Zhangwei Lu, Xiaoning Li, Qian Guo, Yumeng Huo, Qing Xu, Youshan Li, Sheng-Li Cao, Jianchun Wang, Yuan Wang, Jiaxing Zhao, Zhongfeng Li, Miao He, Zhaofeng Luo, Xinhui Lou
Phthalic acid esters(PAEs) are ubiquitous in the environment and some of them are recognized as endocrine disruptors that cause concerns on ecosystem functioning and public health. Due to the diversity of PAEs in the environment, there is a vital need to detect the total concentration of PAEs in a timely and low-cost way. To fulfill this requirement, it is highly desired to obtain group-specific PAE binders that are specific to the basic PAE skeleton. In this study, for the first time we have identified the group-specific PAE-binding aptamers via rational designed target immobilization...
April 17, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28413450/fetal-testis-organ-culture-reproduces-the-dynamics-of-epigenetic-reprogramming-in-rat-gonocytes
#6
Arlette Rwigemera, Fabien Joao, Geraldine Delbes
BACKGROUND: Epigenetic reprogramming is a critical step in male germ cell development that occurs during perinatal life. It is characterized by the remodeling of different epigenetic marks such as DNA methylation (5mC) and methylation of histone H3. It has been suggested that endocrine disruptors can affect the male germline epigenome by altering epigenetic reprogramming, but the mechanisms involved are still unknown. We have previously used an organ culture system that maintains the development of the different fetal testis cell types, to evaluate the effects of various endocrine disruptors on gametogenesis and steroidogenesis in the rat...
2017: Epigenetics & Chromatin
https://www.readbyqxmd.com/read/28404993/impacts-of-bisphenol-a-and-ethinyl-estradiol-on-male-and-female-cd-1-mouse-spleen
#7
Robin B Gear, Scott M Belcher
The endocrine disruptor bisphenol A (BPA) and the pharmaceutical 17α-ethinyl estradiol (EE) are synthetic chemicals with estrogen-like activities. Despite ubiquitous human exposure to BPA, and the wide-spread clinical use of EE as oral contraceptive adjuvant, the impact of these estrogenic endocrine disrupting chemicals (EDCs) on the immune system is unclear. Here we report results of in vivo dose response studies that analyzed the histology and microstructural changes in the spleen of adult male and female CD-1 mice exposed to 4 to 40,000 μg/kg/day BPA or 0...
April 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28402180/analytical-determination-of-bisphenol-a-bpa-and-bisphenol-analogues-in-paper-products-by-gc-ms-ms
#8
A Jurek, E Leitner
Bisphenol A (BPA; 4-[2-(4-Hydroxyphenyl)propan-2-yl]phenol), a suspected endocrine disruptor with a weak estrogenic activity is used in a variety of consumer products, including food contact materials made of paper and cardboard products. Due to restrictions for the use of BPA because of its potential health risks, BPA is gradually being replaced by other bisphenols, as no limitations exist for these substances. The present study presents a method for the simultaneous analysis of bisphenol A (BPA), bisphenol AF (BPAF), bisphenol B (BPB), bisphenol E (BPE), bisphenol F (BPF) and bisphenol S (BPS) in paper and board products, using gas chromatography-tandem mass spectrometry (GC-MS/MS)...
April 12, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/28392374/evaluation-of-the-toxic-effect-of-endocrine-disruptor-bisphenol-a-bpa-in-the-acute-and-chronic-toxicity-tests-with-pomacea-lineata-gastropod
#9
André Lucas Correa de Andrade, Priscila Rafaela Leão Soares, Stephannie Caroline Barros Lucas da Silva, Marília Cordeiro Galvão da Silva, Thamiris Pinheiro Santos, Marilia Ribeiro Sales Cadena, Pierre Castro Soares, Pabyton Gonçalves Cadena
Bisphenol A (BPA) is a plasticizer and a risk when it interacts with organisms, and can cause changes in the development and reproduction of them. This study aimed to evaluate the effects of BPA, by acute and chronic toxicity tests with neonates and adults of Pomacea lineata. Adults and neonates were divided into groups exposed to BPA (1-20mg/L), or 17β-estradiol (1mg/L) and control in the acute and chronic toxicity tests. Behavior, heart rate, reproduction and hemolymph biochemical analysis were measured...
April 6, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28389628/metabolic-syndrome-endocrine-disruptors-and-prostate-cancer-associations-biochemical-and-pathophysiological-evidences
#10
Vincenzo Quagliariello, Sabrina Rossetti, Carla Cavaliere, Rossella Di Palo, Elvira Lamantia, Luigi Castaldo, Flavia Nocerino, Gianluca Ametrano, Francesca Cappuccio, Gabriella Malzone, Micaela Montanari, Daniela Vanacore, Francesco Jacopo Romano, Raffaele Piscitelli, Gelsomina Iovane, Maria Filomena Pepe, Massimiliano Berretta, Carmine D'Aniello, Sisto Perdonà, Paolo Muto, Gerardo Botti, Gennaro Ciliberto, Bianca Maria Veneziani, Francesco De Falco, Piera Maiolino, Michele Caraglia, Maurizio Montella, Rosario Vincenzo Iaffaioli, Gaetano Facchini
This review summarizes the main pathophysiological basis of the relationship between metabolic syndrome, endocrine disruptor exposure and prostate cancer that is the most common cancer among men in industrialized countries. Metabolic syndrome is a cluster of metabolic and hormonal factors having a central role in the initiation and recurrence of many western chronic diseases including hormonal-related cancers and it is considered as the world's leading health problem in the coming years. Many biological factors correlate metabolic syndrome to prostate cancer and this review is aimed to focus, principally, on growth factors, cytokines, adipokines, central obesity, endocrine abnormalities and exposure to specific endocrine disruptors, a cluster of chemicals, to which we are daily exposed, with a hormone-like structure influencing oncogenes, tumor suppressors and proteins with a key role in metabolism, cell survival and chemo-resistance of prostate cancer cells...
March 30, 2017: Oncotarget
https://www.readbyqxmd.com/read/28388912/environmental-pollutants-a-possible-etiology-for-premature-ovarian-insufficiency-a-narrative-review-of-animal-and-human-data
#11
REVIEW
Pauline Vabre, Nicolas Gatimel, Jessika Moreau, Véronique Gayrard, Nicole Picard-Hagen, Jean Parinaud, Roger D Leandri
BACKGROUND: Because only 25% of cases of premature ovarian insufficiency (POI) have a known etiology, the aim of this review was to summarize the associations and mechanisms of the impact of the environment on this pathology. Eligible studies were selected from an electronic literature search from the PUBMED database from January 2000 to February 2016 and associated references in published studies. Search terms included ovary, follicle, oocyte, endocrine disruptor, environmental exposure, occupational exposure, environmental contaminant, pesticide, polyaromatic hydrocarbon, polychlorinated biphenyl PCB, phenol, bisphenol, flame retardant, phthalate, dioxin, phytoestrogen, tobacco, smoke, cigarette, cosmetic, xenobiotic...
April 7, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/28387320/endocrine-disruptors-chemical-contaminants-a-toxic-mixture-for-neurodevelopment
#12
Morgan E Hernandez, Andrea C Gore
No abstract text is available yet for this article.
April 7, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28384430/low-doses-of-bisphenol-a-can-impair-postnatal-testicular-development-directly-without-affecting-hormonal-or-oxidative-stress-levels
#13
Fernanda M Ogo, Glaucia E M L Siervo, Géssica D Gonçalves, Rubens Cecchini, Flavia A Guarnier, Janete Ap Anselmo-Franci, Glaura S A Fernandes
Bisphenol A (BPA) is considered a potent endocrine disruptor, causing changes in the endocrine system due to its oestrogenic activity. Male individuals may be susceptible to endocrine, morphological and physiological alterations during testicular postnatal development. The aim of the present study was to evaluate whether exposure to BPA during the peripubertal period can damage testicular development. To this end, male Wistar rats were treated with BPA via gavage at doses of 20 or 200µgkg-1 on Postnatal Days (PND) 36-66...
April 7, 2017: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/28371731/proteomic-response-of-macrobrachium-rosenbergii-hepatopancreas-exposed-to-chlordecone-identification-of-endocrine-disruption-biomarkers
#14
Anne Lafontaine, Dominique Baiwir, Célia Joaquim-Justo, Edwin De Pauw, Soazig Lemoine, Céline Boulangé-Lecomte, Joëlle Forget-Leray, Jean-Pierre Thomé, Eric Gismondi
The present work is the first study investigating the impacts of chlordecone, an organochlorine insecticide, on the proteome of the decapod crustacean Macrobrachium rosenbergii, by gel-free proteomic analysis. The hepatopancreas protein expression variations were analysed in organisms exposed to three environmental relevant concentrations of chlordecone (i.e. 0.2, 2 and 20µg/L). Results revealed that 62 proteins were significantly up- or down-regulated in exposed prawns compared to controls. Most of these proteins are involved in important physiological processes such as ion transport, defense mechanisms and immune system, cytoskeleton dynamics, or protein synthesis and degradation...
March 31, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28371296/population-exposure-to-phthalate-containing-drugs
#15
Anne Broe, Zandra Nymand Ennis, Anton Pottegård, Jesper Hallas, Thomas Ahern, Per Damkier
Phthalates are known endocrine disruptors. Not commonly recognised, phthalates are used as excipients in a number of drug formulations. We aimed to describe the sale of phthalate-containing drugs in Denmark from 2004 to 2015. National data on annual sale of medications (tablets only) were accessed from medstat.dk. Data from the Danish Medicines Agency on phthalate content per tablet were merged with data on total sale for each active substance and drug formulation. We used the 'defined daily dose' (DDD) as the unit of sale and calculated the total amount of phthalate (mg) dispensed per 1,000 inhabitants...
March 29, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28369636/maternal-fenvalerate-exposure-induces-fetal-intrauterine-growth-restriction-through-disrupting-placental-thyroid-hormone-receptor-signaling
#16
Bo Wang, Ji-Jie Liu, Yan Wang, Lin Fu, Ru Shen, Zhen Yu, Hua Wang, Yuan-Hua Chen, Cheng Zhang, Xiu-Hong Meng, De-Xiang Xu
Fenvalerate is an environmental endocrine disruptor that disrupts testosterone and estradiol synthesis. Nevertheless, whether fenvalerate disturbs placental TR signaling remains unclear. The aim of this study was to investigate whether maternal fenvalerate exposure causes fetal intrauterine growth restriction (IUGR) and to explore the role of placental thyroid hormone receptor (TR) signaling. Pregnant mice except controls were orally administered to fenvalerate (0.2, 2.0 or 20 mg/kg) daily throughout pregnancy...
March 23, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28365492/interaction-of-mycotoxin-zearalenone-with-human-serum-albumin
#17
Miklós Poór, Sándor Kunsági-Máté, Mónika Bálint, Csaba Hetényi, Zsófia Gerner, Beáta Lemli
Zearalenone (ZEN) is a mycotoxin produced mainly by Fusarium species. Fungal contamination of cereals and plants can result in the formation of ZEN, leading to its presence in different foods, animal feeds, and drinks. Because ZEN is an endocrine disruptor, it causes reproductive disorders in farm animals and hyperoestrogenic syndromes in humans. Despite toxicokinetic properties of ZEN were studied in more species, we have no information regarding the interaction of ZEN with serum albumin. Since albumin commonly plays an important role in the toxicokinetics of different toxins, interaction of ZEN with albumin has of high biological importance...
March 27, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28363854/effects-of-individual-and-combined-toxicity-of-bisphenol-a-dibutyl-phthalate-and-cadmium-on-oxidative-stress-and-genotoxicity-in-hepg-2%C3%A2-cells
#18
Xiaohui Li, Pinghe Yin, Ling Zhao
Bisphenol A, dibutyl phthalate and cadmium can be found in environment simultaneously. Several studies suggested that they had genotoxic effect. In this study, mono-exposure and co-exposure treatments, designed by 3 × 3 full factorial, were established to determine the individual toxicity and binary mixtures' combined effects on the oxidative stress and genotoxicity in HepG 2 cells. The highest oxidative damage was observed in the Cd treatments groups. Compared with control groups, the maximum level of reactive oxygen species and malondialdehyde were ∼1...
March 28, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28361461/bisphenol-a-removal-by-submerged-macrophytes-and-the-contribution-of-epiphytic-microorganisms-to-the-removal-process
#19
Guosen Zhang, Yu Wang, Jinhui Jiang, Shao Yang
Bisphenol A (BPA), a typical endocrine disruptor, has been found in global aquatic environments, causing great concern. The capabilities of five common submerged macrophytes to remove BPA from water and the contributions of epiphytic microorganisms were investigated. Macrophytes removed 62%-100% of total BPA (5 mg/L) over 12 days; much higher rates than that observed in the control (2%, F = 261.511, p = 0.000). Ceratophyllum demersum was the most efficient species. C. demersum samples from lakes with different water qualities showed no significant differences in BPA removal rates...
March 31, 2017: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28361414/cytophysiological-changes-in-the-follicular-epithelium-of-the-thyroid-gland-after-long-term-exposure-to-low-doses-of-dichlorodiphenyltrichloroethane-ddt
#20
N V Yaglova, V V Yaglov
Exposure to endocrine disruptors is considered as a risk factor thyroid gland diseases. We analyzed cytophysiological changes in rat thyroid follicular epithelium after long-term exposure to low doses of the most widespread disruptor DDT. Analysis of thyroid hormone production and light and electron microscopy of thyroid gland samples revealed cytophysiological changes in thyroid epithelium related to impaired transport through the apical membrane, suppressed Golgi complex activity, and impaired thyrotrophic hormone regulation of the secretory functions of thyroid cells, which led to compensatory transition from merocrine to microapocrine secret release...
March 30, 2017: Bulletin of Experimental Biology and Medicine
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