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Endocrine disruptors

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https://www.readbyqxmd.com/read/27902454/environmental-chemicals-as-endocrine-disruptors
#1
David O Carpenter, Peter D Sly
No abstract text is available yet for this article.
December 1, 2016: Reviews on Environmental Health
https://www.readbyqxmd.com/read/27901017/daily-intake-and-hazard-index-of-parabens-based-upon-24%C3%A2-h-urine-samples-of-the-german-environmental-specimen-bank-from-1995-to-2012
#2
Rebecca K Moos, Petra Apel, Christa Schröter-Kermani, Marike Kolossa-Gehring, Thomas Brüning, Holger M Koch
In recent years, exposure to parabens has become more of a concern because of evidence of ubiquitous exposure in the general population, combined with evidence of their potency as endocrine disruptors. New human metabolism data from oral exposure experiments enable us to back calculate daily paraben intakes from urinary paraben levels. We report daily intakes (DIs) for six parabens based on 660 24 h urine samples from the German Environmental Specimen Bank collected between 1995 and 2012. Median DI values ranged between 1...
November 30, 2016: Journal of Exposure Science & Environmental Epidemiology
https://www.readbyqxmd.com/read/27890585/cadmium-in%C3%A2-vivo-exposure-alters-stress-response-and-endocrine-related-genes-in-the-freshwater-snail-physa-acuta-new-biomarker-genes-in-a-new-model-organism
#3
Pedro Martínez-Paz, Mónica Morales, Paloma Sánchez-Argüello, Gloria Morcillo, José Luis Martínez-Guitarte
The freshwater snail Physa acuta is a sensitive organism to xenobiotics that is appropriate for toxicity testing. Cadmium (Cd) is a heavy metal with known toxic effects on several organisms, which include endocrine disruption and activation of the cellular stress responses. There is scarce genomic information on P. acuta; hence, in this work, we identify several genes related to the hormonal system, the stress response and the detoxification system to evaluate the effects of Cd. The transcriptional activity of the endocrine-related genes oestrogen receptor (ER), oestrogen-related receptor (ERR), and retinoid X receptor (RXR), the heat shock proteins genes hsp70 and hsp90 and a metallothionein (MT) gene was analysed in P...
November 24, 2016: Environmental Pollution
https://www.readbyqxmd.com/read/27884139/brominated-flame-retardants-in-placental-tissues-associations-with-infant-sex-and-thyroid-hormone-endpoints
#4
Christopher Leonetti, Craig M Butt, Kate Hoffman, Stephanie C Hammel, Marie Lynn Miranda, Heather M Stapleton
BACKGROUND: Brominated flame retardants (BFRs) are endocrine disruptors that bioaccumulate in the placenta, but it remains unclear if they disrupt tissue thyroid hormone (TH) metabolism. Our primary goal was to investigate associations between placental BFRs, TH levels, Type 3 deiodinase (DIO3) activity and TH sulfotransferase (SULT) activities. METHODS: Placenta samples collected from 95 women who delivered term (>37 weeks) infants in Durham, NC, USA (enrolled 2010-2011) were analyzed for polybrominated diphenyl ethers (PBDEs), 2,4,6-tribromophenol (2,4,6-TBP), THs (T4, T3 and rT3), and DIO3 and TH SULT activities...
November 25, 2016: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/27875720/multi-generational-xenoestrogenic-effects-of-perfluoroalkyl-acids-pfaas-mixture-on-oryzias-latipes-using-a-flow-through-exposure-system
#5
Jin Wuk Lee, Jae-Woo Lee, Yu-Jin Shin, Ji-Eun Kim, Tae-Kwon Ryu, Jisung Ryu, Jaean Lee, Pilje Kim, Kyunghee Choi, Kyunghwa Park
To elucidate the multi-generational estrogenic potential of Perfluoroalkyl acids (PFAAs) mixture, vitellogenin (VTG) expression, growth indices, histological alteration, fecundity, hatching rate, larval survival rate, and sex ratio of Japanese medaka (Oryzias latipes) were investigated by exposing the fish to a mixture of perfluorooctane sulfonate (PFOS), perfluroroctanoic acid (PFOA), perfluorobutane sulfonate (PFBS), and perfluorononanoic acid (PFNA) for three generations (238 days). Mixture composition is in the ratio of 1:1:1:1...
November 19, 2016: Chemosphere
https://www.readbyqxmd.com/read/27867807/screening-for-potential-endocrine-disruptors-in-fish-evidence-from-structural-alerts-and-in-vitro-and-in-vivo-toxicological-assays
#6
Monika Nendza, Andrea Wenzel, Martin Müller, Geertje Lewin, Nelly Simetska, Frauke Stock, Jürgen Arning
BACKGROUND: The European chemicals' legislation REACH aims to protect man and the environment from substances of very high concern (SVHC). Chemicals like endocrine disruptors (EDs) may be subject to authorization. Identification of (potential) EDs with regard to the environment is limited because specific experimental assessments are not standard requirements under REACH. Evidence is based on a combination of in vitro and in vivo experiments (if available), expert judgement, and structural analogy with known EDs...
2016: Environmental Sciences Europe
https://www.readbyqxmd.com/read/27856373/a-systematic-study-of-the-release-of-bisphenol-a-by-orthodontic-materials-and-its-biological-effects
#7
Abdelali Halimi, Hicham Benyahia, Loubna Bahije, Hanane Adli, Mohamed-Faouzi Azeroual, Fatima Zaoui
INTRODUCTION: Bisphenol A (BPA) is a synthetic chemical substance used as a starting ingredient in the manufacturing process of a number or orthodontic materials. It is a well-known endocrine disruptor with low estrogenic properties. The aim of this investigation is to present a systematic review regarding the issue of bisphenol A release by orthodontic materials and its impact in orthodontics. MATERIALS AND METHODS: A systematic analysis was performed by electronic search (between 1936 and 2015) on several data bases...
November 14, 2016: International Orthodontics
https://www.readbyqxmd.com/read/27856274/improved-assessment-of-sensorimotor-gating-in-animal-models-relevant-to-asd-a-data-modelling-approach-to-quantify-prepulse-inhibition-of-the-acoustic-startle-reflex
#8
Stéphanie Degroote, Darel Hunting, Larissa Takser
BACKGROUND: The PrePulse Inhibition (PPI) of the acoustic startle reflex is a neurobehavioral test frequently used in neurodevelopmental studies. Most PPI studies have used rodent models of schizophrenia; however, the currently used data analysis method does not take into account the variability present in autistic preclinical models. NEW METHOD: We propose a new data modelling approach for PPI data obtained from animals exposed to valproic acid or endocrine disruptors, using mixed modeling; and a new calculation of inhibition of the acoustic startle, which takes into account the habituation phenomenon...
November 14, 2016: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/27853917/benzene-and-2-ethyl-phthalate-induce-proliferation-in-normal-rat-pituitary-cells
#9
Laura Tapella, Antonella Sesta, Maria Francesca Cassarino, Valentina Zunino, Maria Graziella Catalano, Francesca Pecori Giraldi
PURPOSE: Endocrine disruptors are known to modulate a variety of endocrine functions and increase the risk for neoplasia. Epidemiological data reported increased prevalence of pituitary tumors in high industrial areas while genotyping studies showed that mutations in the aryl hydrocarbon receptor (AhR) interacting protein (AIP)-chaperone to the dioxin ligand AhR-gene are linked to predisposition to pituitary tumor development. Aim of the present study was to establish whether endocrine pollutants can induce cell proliferation in normal rat pituitary cells...
November 16, 2016: Pituitary
https://www.readbyqxmd.com/read/27852690/maternal-use-of-mild-analgesics-during-pregnancy-associated-with-reduced-anogenital-distance-in-sons-a-cohort-study-of-1027-mother-child-pairs
#10
Dorte Vesterholm Lind, Katharina M Main, Henriette Boye Kyhl, David Møbjerg Kristensen, Jorma Toppari, Helle Raun Andersen, Marianne Skovsager Andersen, Niels E Skakkebæk, Tina Kold Jensen
STUDY QUESTION: Is maternal use of mild analgesics in pregnancy associated with anogenital distance (AGD)-the distance from the anus to the genitals-in the offspring? SUMMARY ANSWER: Maternal use of mild analgesics [especially simultaneous use of paracetamol and nonsteroidal anti-inflammatory drugs (NSAIDs)] during pregnancy was associated with a shorter AGD in boys whereas no effect was found in girls. WHAT IS KNOWN ALREADY: Mild analgesics including paracetamol (acetaminophen) and NSAIDs (e...
November 16, 2016: Human Reproduction
https://www.readbyqxmd.com/read/27845755/effects-of-di-2-ethylhexyl-phthalate-on-the-hypothalamus-uterus-in-pubertal-female-rats
#11
Te Liu, Yiyang Jia, Liting Zhou, Qi Wang, Di Sun, Jin Xu, Juan Wu, Huaiji Chen, Feng Xu, Lin Ye
The pollution of endocrine disruptors and its impact on human reproductive system have attracted much attention. Di-(2-ethylhexyl) phthalate (DEHP), an environmental endocrine disruptor, is widely used in food packages, containers, medical supplies and children's toys. It can cause diseases such as infertility, sexual precocity and uterine bleeding and thus arouse concerns from the society and scholars. The effect of DEHP on pubertal female reproductive system is still not well-studied. This study was to investigate the effects of DEHP on the hypothalamus-uterus in pubertal female rats, reveal the reproductive toxicity of DEHP on pubertal female rats and its mechanism, and provide scientific evidence for the evaluation of toxicity and toxic mechanism of DEHP on reproductive system...
November 12, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27837466/thyroid-disruption-by-perfluorooctane-sulfonate-pfos-and-perfluorooctanoate-pfoa
#12
REVIEW
F Coperchini, O Awwad, M Rotondi, F Santini, M Imbriani, L Chiovato
BACKGROUND: Perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) are two fluorinated compounds widely used in industry because of their useful chemical characteristics. They were identified as endocrine disruptors due to their ability to interfere with thyroid function. The resistance of PFOA and PFOS to environmental degradation, their bio-accumulation in food chains, and their long half-life raised concern in the scientific community, and several studies were performed with the aim to establish the real dangerousness of these compounds for the human health...
November 11, 2016: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/27836535/effect-of-the-herbicide-atrazine-and-its-metabolite-dact-on-bovine-sperm-quality
#13
Alisa Komsky-Elbaz, Zvi Roth
Atrazine (ATZ), one of the most extensively used herbicides, is considered a ubiquitous environmental contaminant. ATZ is a known endocrine disruptor, and deleterious effects on reproductive function have been shown, even at low, ecologically relevant doses (0.1-3μg/L). Once it enters the body, ATZ is metabolized to various metabolites, which are further detected in the urine, serum and tissues. In mammals, the major ATZ metabolite is diaminochlorotriazine (DACT). The current study focuses on direct effects of low doses of ATZ and DACT on bovine sperm isolated from ejaculates or epididymis compartments (head, body and tail)...
November 9, 2016: Reproductive Toxicology
https://www.readbyqxmd.com/read/27826822/an-updated-systematic-review-on-the-possible-effect-of-nonylphenol-on-male-fertility
#14
Zahra Noorimotlagh, Neemat Jaafarzadeh Haghighi, Mehdi Ahmadimoghadam, Fakher Rahim
Diverse industries like detergents, resins and polymers, hair dyes, intravaginal spermicides, and pesticides produce endocrine disruptor (ED)-containing wastewaters that have hazardous effects on the environment and public health. Nonylphenol (NP) is a chemical substance that consists of a phenolic group and an attached lipophilic linear nonyl chain. NP has weak estrogenic activity and affects estrogen receptor (ER), as well as induces male infertility via a negative impact on spermatogenesis and sperm quality...
November 8, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27810580/the-influence-of-control-group-reproduction-on-the-statistical-power-of-the-environmental-protection-agency-s-medaka-extended-one-generation-reproduction-test-meogrt
#15
Kevin Flynn, Joe Swintek, Rodney Johnson
Because of various Congressional mandates to protect the environment from endocrine disrupting chemicals (EDCs), the United States Environmental Protection Agency (USEPA) initiated the Endocrine Disruptor Screening Program. In the context of this framework, the Office of Research and Development within the USEPA developed the Medaka Extended One Generation Reproduction Test (MEOGRT) to characterize the endocrine action of a suspected EDC. One important endpoint of the MEOGRT is fecundity of medaka breeding pairs...
October 27, 2016: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/27794445/heavy-metals-in-the-volcanic-environment-and-thyroid-cancer
#16
R Vigneri, P Malandrino, F Gianì, M Russo, P Vigneri
In the last two decades thyroid cancer incidence has increased worldwide more than any other cancer. Overdiagnosis of subclinical microcarcinomas has certainly contributed to this increase but many evidences indicate that a true increase, possibly due to environmental factors, has also occurred. Thyroid cancer incidence is markedly increased in volcanic areas. Thus, the volcanic environment is a good model to investigate the possible factors favoring thyroid cancer. In the volcanic area of Mt. Etna in Sicily, as well as in other volcanic areas, a non-anthropogenic pollution with heavy metals has been documented, a consequence of gas, ash and lava emission...
October 26, 2016: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/27789757/population-attributable-risks-and-costs-of-diabetogenic-chemical-exposures-in-the-elderly
#17
Leonardo Trasande, Erik Lampa, Lars Lind, P Monica Lind
BACKGROUND: A previous analysis examined the contribution of endocrine disruptor exposures (endocrine-disrupting chemicals, EDCs) to adult diabetes, but was limited to effects of phthalates in middle-aged women and did not simultaneously examine multiple EDCs which are known to coexist in the environment. We therefore endeavoured to quantify potential reductions in diabetes and disease costs that could result from reducing synthetic chemical diabetogenic exposures in the elderly in Europe...
October 27, 2016: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/27787652/transcriptional-control-of-apoptotic-cell-clearance-by-macrophage-nuclear-receptors
#18
Tamás Röszer
Apoptotic cell clearance by macrophages is key for normal tissue development and homeostasis. Nuclear receptors, such as peroxisome proliferator activated receptors (PPARs), liver X receptor (LXR), retinoic acid receptor (RAR), retinoid X receptor (RXR) and glucocorticoid receptor (GR) orchestrate this vital process. The underlying mechanism involves the transcriptional control of key genes of apoptotic cell recognition and internalization, such as Cd36, Mertk, Axl, C1qa, Tgm2, Abca1. In addition, apoptotic cell uptake leads to M2 activation of macrophages, and this process is also controlled at the gene transcription level by nuclear receptors...
October 27, 2016: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/27776203/obesogens-and-male-fertility
#19
A M Cardoso, M G Alves, P P Mathur, P F Oliveira, J E Cavaco, L Rato
In the last decades, several studies evidenced a decrease in male fertility in developed countries. Although the aetiology of this trend in male reproductive health remains a matter of debate, environmental compounds that predispose to weight gain, namely obesogens, are appointed as contributors because of their action as endocrine disruptors. Obesogens favour adipogenesis by an imbalance of metabolic processes and can be found virtually everywhere. These compounds easily accumulate in tissues with high lipid content...
October 24, 2016: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/27771877/removal-of-methylparaben-from-synthetic-aqueous-solutions-using-polyacrylonitrile-beads-kinetic-and-equilibrium-studies
#20
Maurizio Forte, Luigi Mita, Rosa Perrone, Sergio Rossi, Mario Argirò, Damiano Gustavo Mita, Marco Guida, Marianna Portaccio, Tzonka Godievargova, Yavour Ivanov, Mahmoud T Tamer, Ahmed M Omer, Mohamed S Mohy Eldin
The removal of methylparaben (MP), a well-known endocrine disruptor, from aqueous solutions using polyacrylonitrile (PAN) beads has been studied under batch conditions, at room temperature and at different initial MP concentrations. The kinetic and equilibrium results have been analyzed. Kinetic modeling analysis has been carried out with three different types of adsorption models: pseudo-first-order, pseudo-second-order, and Elovich model. Kinetic data analysis indicated that the adsorption was a second-order process...
October 22, 2016: Environmental Science and Pollution Research International
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