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Endocrine disruptors

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https://www.readbyqxmd.com/read/28928807/effects-of-low-dose-of-bisphenol-a-on-the-proliferation-and-mechanism-of-primary-cultured-prostate-epithelial-cells-in-rodents
#1
Dongyan Huang, Jianhui Wu, Xin Su, Han Yan, Zuyue Sun
Bisphenol A (BPA) is a well-known endocrine disruptor compound (EDC) that aggravates testosterone-induced benign prostate hyperplasia by increasing the relative weight of the ventral and dorsolateral prostate in rats. This phenomenon is primarily attributed to the exogenous estrogen effect of BPA. However, the direct effect of BPA on prostate cells has not been characterized. The present study investigated the proliferative effect and possible mechanisms of action of BPA on the prostatic epithelium of rats...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28928476/bisphenol-a-affects-on-the-functional-properties-and-proteome-of-testicular-germ-cells-and-spermatogonial-stem-cells-in-vitro-culture-model
#2
Polash Chandra Karmakar, Hyun-Gu Kang, Yong-Hee Kim, Sang-Eun Jung, Md Saidur Rahman, Hee-Seok Lee, Young-Hyun Kim, Myung-Geol Pang, Buom-Yong Ryu
The endocrine disruptor bisphenol A (BPA) is well known for its adverse effect on male fertility. Growing evidence suggests that BPA may interact with testicular germ cells and cause infertility as a result of its estrogenic activity. Objective of current in vitro study was to investigate the proliferation, survivability and stemness properties of mouse testicular germ cells exposed to BPA, and to evaluate possible expression of cellular proteome. Our results showed that germ cell viability and proliferation were not affected by low concentrations (0...
September 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28919451/biphasic-modulation-of-neuro-and-interrenal-steroidogenesis-in-juvenile-african-sharptooth-catfish-clarias-gariepinus-exposed-to-waterborne-di-2-ethylhexyl-phthalate
#3
Augustine Arukwe, Oju R Ibor, Aina O Adeogun
Receptor (i.e genomic) and non-receptor (or non-genomic) effects of endocrine toxicology have received limited or almost non-existent attention for tropical species and regions. In the present study, we have studied the effects of di-(2-ethylhexyl) phthalate (DEHP) on neuro- and interrenal steroidogenesis of the African catfish (Clarias gariepinus) using molecular, immunochemical and physiological approaches. Juvenile fish (mean weight and length: 5.6 ± 0.6g and 8.2 ± 1.2 cm, respectively), were randomly distributed into ten 120 L rectangular glass tanks containing 60 L of dechlorinated tap water, at 50 fish per exposure group...
September 14, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28918853/hormone-related-cancers-and-endocrine-disruptors-new-aspects-of-an-old-question
#4
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
December 5, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28916285/profiling-of-bisphenol-s-towards-nuclear-receptors-activities-in-human-reporter-cell-lines
#5
Ondrej Zenata, Zdenek Dvorak, Radim Vrzal
Bisphenol S (BPS) is heat-stable structural analog of bisphenol A (BPA), a known endocrine disruptor. Due to the effort to replace BPA with BPS, it is essential to know if BPS is suitable non-toxic replacement without reported deleterious effects of BPA. Since most of the BPA effects are ascribed to its ability to activate nuclear receptors, we screened some prominent members of this family in order to confirm or refute some recent findings. We found that BPS insignificantly activated aryl hydrocarbon receptor (AhR) in reporter gene assay and no induction of AhR target gene CYP1A1 was observed in human hepatocytes (HH)...
September 12, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28915546/emergent-contaminants-endocrine-disruptors-and-their-laccase-assisted-degradation-a-review
#6
REVIEW
Carlos Barrios-Estrada, Magdalena de Jesús Rostro-Alanis, Blanca Delia Muñoz-Gutiérrez, Hafiz M N Iqbal, Soundarapandian Kannan, Roberto Parra-Saldívar
Herein, an effort has been made to highlight the trends of the state-of-the-art of laccase-assisted degradation of emerging contaminants at large and endocrine disruptors in particular. Since first described in the 19th century, laccase has received particular interest for inter- and multidisciplinary investigations due to its uniqueness and remarkable biotechnological applicability. There has always been a paramount concern over the widespread occurrences of various pollutant types, around the globe. Therefore, pollution free processes are gaining ground all over the world...
September 11, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28915506/maternal-diethylhexyl-phthalate-exposure-affects-adiposity-and-insulin-tolerance-in-offspring-in-a-pcna-dependent-manner
#7
Brian G Hunt, Yuan-Liang Wang, Min-Shan Chen, Shao-Chun Wang, Susan E Waltz
The ubiquitous plasticizer, diethylhexyl phthalate (DEHP), is a known endocrine disruptor. However, DEHP exposure effects are not well understood. Changes in industrial and agricultural practices have resulted in increased prevalence of DEHP exposure and has coincided with the heightened occurrence of metabolic syndrome and obesity. DEHP and its metabolites are detected in the umbilical cord blood of newborns; however, the prenatal and perinatal effects of DEHP exposure have not been intensively studied. Previously, we discovered that phosphorylation (p) of proliferating cell nuclear antigen (PCNA) at tyrosine 114 (Y114) is required for adipogenesis and diet-induced obesity in mice...
September 12, 2017: Environmental Research
https://www.readbyqxmd.com/read/28915396/a-novel-biodegradation-pathway-of-the-endocrine-disruptor-di-2-ethyl-hexyl-phthalate-by-pleurotus-ostreatus-based-on-quantum-chemical-investigation
#8
Miriam Ahuactzin-Pérez, Saúl Tlecuitl-Beristain, Jorge García-Dávila, Ericka Santacruz-Juárez, Manuel González-Pérez, María Concepción Gutiérrez-Ruíz, Carmen Sánchez
Di(2-ethyl hexyl) phthalate (DEHP) is a plasticizer that interfere with endocrine systems in mammals. Growth parameters for Pleurotus ostreatus grown on media containing glucose and different concentrations of DEHP (0, 500 and 1000mg/L) were evaluated. The highest biomass production was observed in medium supplemented with 1000mg of DEHP/L. Half-life of DEHP biodegradation, biodegradation constant of DEHP, and percentage of removal efficiency (%E) were also determined. P. ostreatus degraded 100% of DEHP after 504h...
September 12, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28915126/toxicological-profile-of-organochlorines-aldrin-and-dieldrin-an-indian-perspective
#9
REVIEW
Noopur Sharma, Deepali Garg, Roumi Deb, Ratika Samtani
Several epidemiological studies have suggested various environmental factors as a possible cause for increased incidence of various abnormalities. Of the various environmental contaminants, the most prevalent and the most discussed are the endocrine disrupting chemicals. Contact of such disruptors with humans has become inevitable today. They are cosmopolitan and present from agriculture to industrial sectors, even in day-to-day consumer products. Aldrin and dieldrin belong to one such class of substances which are known to have a toxic effect on various physiological systems of the human body...
September 15, 2017: Reviews on Environmental Health
https://www.readbyqxmd.com/read/28914781/response-to-elwood-m-et-al-comment-on-maternal-exposure-to-domestic-hair-cosmetics-and-occupational-endocrine-disruptors-is-associated-with-a-higher-risk-of-hypospadias-in-the-offspring-int-j-environ-res-public-health-2017-14-27
#10
Elodie Haraux, Karine Braun, Philippe Buisson, Erwan Stéphan-Blanchard, Camille Devauchelle, Jannick Ricard, Bernard Boudailliez, Pierre Tourneux, Richard Gouron, Karen Chardon
Dear Editor, Thank you for inviting us to reply to a "Comment" paper to our published paper "Maternal Exposure to Domestic Hair Cosmetics and Occupational Endocrine Disruptors Is Associated with a Higher Risk of Hypospadias in the Offspring" (Authors: Elodie Haraux, Karine Braun, Philippe Buisson, Erwan Stéphan-Blanchard, Jannick Ricard, Camille Devauchelle, Bernard Boudailliez, Pierre Tourneux, Richard Gouron, Karen Chardon).[...].
September 15, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28911802/transient-gestational-exposure-to-drinking-water-containing-excess-hexavalent-chromium-modifies-insulin-signaling-in-liver-and-skeletal-muscle-of-rat-progeny
#11
Navaneethabalakrishnan Shobana, Mariajoseph Michael Aruldhas, Lalmuankimi Tochhawng, Ayyalu Loganathan, Sadhasivam Balaji, Mani Kathiresh Kumar, Liaquat Alikhan Sheerin Banu, Ajit Kumar Navin, Chinnaiyan Mayilvanan, Ramachandran Ilangovan, Karundevi Balasubramanian
Chromium (Cr), an essential micronutrient potentiates insulin action, whereas excess hexavalent Cr (CrVI) acts as an endocrine disruptor. Pregnant mothers living in areas abutting industries using the metal and chromite ore dumps are exposed to ground water contaminated with Cr. Nevertheless, the impact of prenatal exposure to excess CrVI on insulin signaling in the progeny remains obscure. We tested the hypothesis "transient gestational exposure to drinking water containing excess CrVI may modify insulin signaling during postnatal life"...
September 11, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28910977/bisphenol-a-induced-apoptosis-and-transcriptome-differences-of-spermatogonial-stem-cells-in-vitro
#12
Xiaowen Gong, Hui Xie, Xiaoyong Li, Ji Wu, Yi Lin
Bisphenol A (BPA) is widely used as an industrial plasticizer, which is also an endocrine disruptor and considered to have adverse effects on reproduction. In male mammals, the long-term production of billions of spermatozoa relies on the regulated proliferation and differentiation of spermatogonial stem cells (SSCs). However, little is known about the effects of BPA on the viability of SSCs. To investigate the influence of BPA exposure on SSCs in vitro, we isolated SSCs from mouse and successfully established in vitro propagation of SSCs...
September 1, 2017: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/28906429/comment-on-maternal-exposure-to-domestic-hair-cosmetics-and-occupational-endocrine-disruptors-is-associated-with-a-higher-risk-of-hypospadias-in-the-offspring-int-j-environ-res-public-health-2017-14-27
#13
Mark Elwood, Dillon O'Brien, Katie-Anne Budgen
There are considerable inconsistencies in the results of Haraux et al. [1].[...].
September 14, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28903489/from-the-cover-exposure-to-an-environmentally-relevant-mixture-of-brominated-flame-retardants-decreased-p-%C3%AE-cateninser675-expression-and-its-interaction-with-e-cadherin-in-the-mammary-glands-of-lactating-rats
#14
Elham Dianati, Michael G Wade, Barbara F Hales, Bernard Robaire, Isabelle Plante
Proper mammary gland development and function require precise hormonal regulation and bidirectional cross talk between cells provided by means of paracrine factors as well as intercellular junctions; exposure to environmental endocrine disruptors can disturb these processes. Exposure to one such family of chemicals, the brominated flame retardants (BFRs), is ubiquitous. Here, we tested the hypothesis that BFR exposures disrupt signaling pathways and intercellular junctions that control mammary gland development...
September 1, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28902174/distribution-of-non-persistent-endocrine-disruptors-in-two-different-regions-of-the-human-brain
#15
Thomas P van der Meer, Francisco Artacho-Cordón, Dick F Swaab, Dicky Struik, Konstantinos C Makris, Bruce H R Wolffenbuttel, Hanne Frederiksen, Jana V van Vliet-Ostaptchouk
Non-persistent endocrine disrupting chemicals (npEDCs) can affect multiple organs and systems in the body. Whether npEDCs can accumulate in the human brain is largely unknown. The major aim of this pilot study was to examine the presence of environmental phenols and parabens in two distinct brain regions: the hypothalamus and white-matter tissue. In addition, a potential association between these npEDCs concentrations and obesity was investigated. Post-mortem brain material was obtained from 24 individuals, made up of 12 obese and 12 normal-weight subjects (defined as body mass index (BMI) > 30 and BMI < 25 kg/m², respectively)...
September 13, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28898977/from-the-cover-metabolomics-reveals-a-role-of-betaine-in-prenatal-dbp-exposure-induced-epigenetic-transgenerational-failure-of-spermatogenesis-in-rats
#16
Beilei Yuan, Wei Wu, Minjian Chen, Hao Gu, Qiuqin Tang, Dan Guo, Ting Chen, Yiqiu Chen, Chuncheng Lu, Ling Song, Yankai Xia, Daozhen Chen, Virender K Rehan, Jiahao Sha, Xinru Wang
There is increasing concern that early-life exposure to endocrine disruptors affects male offspring reproduction. However, whether di-n-butyl phthalate (DBP), a widely used endocrine disruptor, has transgenerational effects and, if so, the exact underlying molecular mechanisms involved remain unknown. In our study, 5 of time-mated pregnant SD rats were exposed to 0 and 500 mg/kg DBP with corn oil as the vehicle via oral gavage from embryonic days (E8-E14). Epigenetic and metabolomic of testis were analyzed after post-natal 60 days...
August 1, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28895924/artificial-turf-contested-terrains-for-precautionary-public-health-with-particular-reference-to-europe
#17
Andrew Watterson
Millions of adults, children and teenagers use artificial sports pitches and playgrounds globally. Pitches are artificial grass and bases may be made up of crumb rubber from recycled tires or new rubber and sand. Player injury on pitches was a major concern. Now, debates about health focus on possible exposure and uptake of chemicals within pitch and base materials. Research has looked at potential risks to users from hazardous substances such as metals, volatile organic compounds, polycyclic aromatic hydrocarbons including benzo (a) (e) pyrenes and phthalates: some are carcinogens and others may be endocrine disruptors and have developmental reproductive effects...
September 12, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28895675/estrogenic-activity-of-commercial-milk-as-revealed-in-immature-hamster-uterotrophic-assay-%C3%A2-pilot-study
#18
Lidia Radko, Maria Minta, Sylwia Stypuła-Trębas
Background: The risk for public health posed by endocrine disruptors present in food is relatively new issue. Our current understanding of human exposure is mainly based on the residue analysis of selected compounds. With such approach potential, effects of mixtures, including so-far unidentified compounds are not taken into consideration. Therefore, the knowledge of overall hormonal activity in food samples is of big importance. Objective: Milk and dairy products are a rich source of estrogens but very rarely undergo testing for estrogenic activity...
2017: Roczniki Państwowego Zakładu Higieny
https://www.readbyqxmd.com/read/28894220/binding-modes-of-environmental-endocrine-disruptors-to-human-serum-albumin-insights-from-std-nmr-itc-spectroscopic-and-molecular-docking-studies
#19
Hongqin Yang, Yanmei Huang, Jiuyang Liu, Peixiao Tang, Qiaomei Sun, Xinnuo Xiong, Bin Tang, Jiawei He, Hui Li
Given that bisphenols have an endocrine-disrupting effect on human bodies, thoroughly exposing their potential effects at the molecular level is important. Saturation transfer difference (STD) NMR-based binding studies were performed to investigate the binding potential of two bisphenol representatives, namely, bisphenol B (BPB) and bisphenol E (BPE), toward human serum albumin (HSA). The relative STD (%) suggested that BPB and BPE show similar binding modes and orientations, in which the phenolic rings were spatially close to HSA binding site...
September 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28891708/-the-crisis-of-the-hormonal-system-the-health-effects-of-endocrine-disruptors
#20
György Csaba
The endocrine disruptors are natural or arteficial molecules wich are present in the animal (human) environment and entering into the organism. They are bound by hormone receptors, simulating or inhibiting the normal hormonal message. This way they are able to stimulate or hinder the function of the given cell, as well as the synthesis and transport of hormones or receptors. They can cause faulty hormonal imprinting in critical periods of development with lifelong consequences, as alteration of hormone-influenced cell functions, inclination to or manifestation of diseases, so they have medical importance...
September 2017: Orvosi Hetilap
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