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JOURNAL ARTICLE
L Cozijnsen, R L Braam, M Bakker-de Boo, A M Otten, J G Post, T Schermer, B J Bouma, B J M Mulder
AIM: To determine the prevalence of undiagnosed bicuspid aortic valve (BAV) and isolated aortic dilatation in first-degree relatives (FDRs) of patients with isolated BAV and to explore the recurrence risk of BAV in different subgroups of probands with BAV. Recent American College of Cardiology (ACC)/American Heart Association (AHA) Guidelines recommend family screening in patients with associated aortopathy only. METHODS: During follow-up visits, patients with isolated BAV received a printed invitation for their FDRs advising cardiac screening...
April 2022: Netherlands Heart Journal
#22
JOURNAL ARTICLE
Roeland B van Leeuwen, Tjard R Schermer, Carla Colijn, Tjasse D Bruintjes
Background: People with dizziness may experience driving-related limitations. Few data are available about the impact of dizziness on driving. Aim: The aim of this study is to investigate the impact of dizziness on driving, factors related to impairment (age, gender, and type of diagnosis), and the potential consequences for patients' ability to work. We also investigated whether the patients expected and actually received information about their dizziness-related fitness to drive from their physician. Methods: A cross-sectional, observational study was conducted in the Apeldoorn Dizziness Centre, a tertiary care referral centre for patients with dizziness...
2021: Frontiers in Neurology
#23
JOURNAL ARTICLE
Francesca Fabretti, Nikolai Tschernoster, Florian Erger, Andrea Hedergott, Anja K Buescher, Claudia Dafinger, Bjoern Reusch, Vincent K Köntges, Stefan Kohl, Malte P Bartram, Lutz Thorsten Weber, Holger Thiele, Janine Altmueller, Bernhard Schermer, Bodo B Beck, Sandra Habbig
Introduction: Disease-causing mutations in the protocadherin FAT1 have been recently described both in patients with a glomerulotubular nephropathy and in patients with a syndromic nephropathy. Methods: We identified 4 patients with FAT1 -associated disease, performed clinical and genetic characterization, and compared our findings to the previously published patients. Patient-derived primary urinary epithelial cells were analyzed by quantitative polymerase chain reaction (qPCR) and immunoblotting to identify possible alterations in Hippo signaling...
May 2021: KI Reports
#24
JOURNAL ARTICLE
Philip J M Brouwer, Mitch Brinkkemper, Pauline Maisonnasse, Nathalie Dereuddre-Bosquet, Marloes Grobben, Mathieu Claireaux, Marlon de Gast, Romain Marlin, Virginie Chesnais, Ségolène Diry, Joel D Allen, Yasunori Watanabe, Julia M Giezen, Gius Kerster, Hannah L Turner, Karlijn van der Straten, Cynthia A van der Linden, Yoann Aldon, Thibaut Naninck, Ilja Bontjer, Judith A Burger, Meliawati Poniman, Anna Z Mykytyn, Nisreen M A Okba, Edith E Schermer, Marielle J van Breemen, Rashmi Ravichandran, Tom G Caniels, Jelle van Schooten, Nidhal Kahlaoui, Vanessa Contreras, Julien Lemaître, Catherine Chapon, Raphaël Ho Tsong Fang, Julien Villaudy, Kwinten Sliepen, Yme U van der Velden, Bart L Haagmans, Godelieve J de Bree, Eric Ginoux, Andrew B Ward, Max Crispin, Neil P King, Sylvie van der Werf, Marit J van Gils, Roger Le Grand, Rogier W Sanders
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is continuing to disrupt personal lives, global healthcare systems, and economies. Hence, there is an urgent need for a vaccine that prevents viral infection, transmission, and disease. Here, we present a two-component protein-based nanoparticle vaccine that displays multiple copies of the SARS-CoV-2 spike protein. Immunization studies show that this vaccine induces potent neutralizing antibody responses in mice, rabbits, and cynomolgus macaques...
March 4, 2021: Cell
#25
JOURNAL ARTICLE
Fabian Braun, Markus Rinschen, Denise Buchner, Katrin Bohl, Ingo Plagmann, Daniel Bachurski, Martin Richard Späth, Philipp Antczak, Heike Göbel, Corinna Klein, Jan-Wilm Lackmann, Oliver Kretz, Victor G Puelles, Roger Wahba, Michael Hallek, Bernhard Schermer, Thomas Benzing, Tobias B Huber, Andreas Beyer, Dirk Stippel, Christine E Kurschat, Roman-Ulrich Müller
Kidney transplantation is the preferred renal replacement therapy available. Yet, long-term transplant survival is unsatisfactory, partially due to insufficient possibilities of longitudinal monitoring and understanding of the biological processes after transplantation. Small urinary extracellular vesicles (suEVs) - as a non-invasive source of information - were collected from 22 living donors and recipients. Unbiased proteomic analysis revealed temporal patterns of suEV protein signature and cellular processes involved in both early response and longer-term graft adaptation...
October 2020: Journal of Extracellular Vesicles
#26
JOURNAL ARTICLE
Anna Schorcht, Tom L G M van den Kerkhof, Christopher A Cottrell, Joel D Allen, Jonathan L Torres, Anna-Janina Behrens, Edith E Schermer, Judith A Burger, Steven W de Taeye, Alba Torrents de la Peña, Ilja Bontjer, Stephanie Gumbs, Gabriel Ozorowski, Celia C LaBranche, Natalia de Val, Anila Yasmeen, Per Johan Klasse, David C Montefiori, John P Moore, Hanneke Schuitemaker, Max Crispin, Marit J van Gils, Andrew B Ward, Rogier W Sanders
The induction of broadly neutralizing antibodies (bNAbs) is a major goal in vaccine research. HIV-1 infected individuals that develop exceptionally strong bNAb responses, termed elite neutralizers, can inform vaccine design by providing blueprints for the induction of similar bNAb responses. We describe a new recombinant native-like envelope glycoprotein (Env) SOSIP trimer, termed AMC009, based on the viral founder sequences of an elite neutralizer. The subtype B AMC009 SOSIP protein formed stable native-like trimers that displayed multiple bNAb epitopes...
September 30, 2020: Journal of Virology
#27
JOURNAL ARTICLE
Suzanne Boer, Persijn J Honkoop, Rik J B Loijmans, Jiska B Snoeck-Stroband, Willem J J Assendelft, Tjard R J Schermer, Jacob K Sont
BACKGROUND: The aim of this study was to identify patients who benefit most from exhaled nitric oxide fraction ( F ENO )-driven asthma management in primary care, based on prespecified subgroups with different levels of F ENO . METHODS: We used data from 179 adults with asthma from a 12-month primary care randomised controlled trial with 3-monthly assessments of F ENO , asthma control, medication usage, costs of medication, severe asthma exacerbations and quality of life...
July 2020: ERJ Open Research
#28
COMPARATIVE STUDY
Mieke M de Klein, Jeannette B Peters, Alex J van 't Hul, Reinier P Akkermans, Johannes C In 't Veen, Jan H Vercoulen, Erik W Bischoff, Tjard R Schermer
In this study, we compare health status between COPD patients treated in three different care levels in the Netherlands and assess determinants that influence their health status. We applied the Nijmegen Clinical Screening Instrument to measure eight health status subdomains in primary (n = 289), secondary (n = 184) and tertiary care (n = 433) COPD patient cohorts. Proportions of patients with severe problems in ≥3 subdomains are 47% in primary, 71% in secondary and 94% in tertiary care. Corrected for patient characteristics, differences between the care levels are statistically significant for nearly all health status subdomains...
September 8, 2020: NPJ Primary Care Respiratory Medicine
#29
JOURNAL ARTICLE
Julie Aitken Schermer, Lucía Colodro-Conde, Katrina L Grasby, Ian B Hickie, Jane Burns, Lannie Ligthart, Gonneke Willemsen, Timothy J Trull, Nicholas G Martin, Dorret I Boomsma
Loneliness is related to mental and somatic health outcomes, including borderline personality disorder. Here, we analyze the sources of variation that are responsible for the relationship between borderline personality features (including four dimensions, affective instability, identity disturbance, negative relationships, self-harm and a total score) and loneliness. Using genetically informative data from two large nonclinical samples of adult twin pairs from Australia and the Netherlands (N = 11,329), we estimate the phenotypic, genetic and environmental correlations between self-reported borderline personality features and loneliness...
August 2020: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
#30
JOURNAL ARTICLE
Linus Butt, David Unnersjö-Jess, Martin Höhne, Aurelie Edwards, Julia Binz-Lotter, Dervla Reilly, Robert Hahnfeldt, Vera Ziegler, Katharina Fremter, Markus M Rinschen, Martin Helmstädter, Lena K Ebert, Hayo Castrop, Matthias J Hackl, Gerd Walz, Paul T Brinkkoetter, Max C Liebau, Kálmán Tory, Peter F Hoyer, Bodo B Beck, Hjalmar Brismar, Hans Blom, Bernhard Schermer, Thomas Benzing
Mammalian kidneys constantly filter large amounts of liquid, with almost complete retention of albumin and other macromolecules in the plasma. Breakdown of the three-layered renal filtration barrier results in loss of albumin into urine (albuminuria) across the wall of small renal capillaries, and is a leading cause of chronic kidney disease. However, exactly how the renal filter works and why its permeability is altered in kidney diseases is poorly understood. Here we show that the permeability of the renal filter is modulated through compression of the capillary wall...
May 2020: Nature metabolism
#31
JOURNAL ARTICLE
Rajender R Aparasu, Sneha Sura, Jagadeswara R Earla, Aki Shiozawa, Daniel B Ng, Carol R Schermer
INTRODUCTION: Although antimuscarinics form the first-line therapy in overactive bladder (OAB), little is known regarding antimuscarinic discontinuation among OAB patients in nursing homes. This study examined treatment patterns and predictors of antimuscarinic discontinuation among long-term nursing home (LTNH) residents with OAB. METHODS: The study cohort included LTNH residents (defined as residents staying ≥ 101 consecutive days) from the Minimum Data Set linked 2013-2015 Medicare claims data...
August 2020: Advances in Therapy
#32
JOURNAL ARTICLE
Philip J M Brouwer, Tom G Caniels, Karlijn van der Straten, Jonne L Snitselaar, Yoann Aldon, Sandhya Bangaru, Jonathan L Torres, Nisreen M A Okba, Mathieu Claireaux, Gius Kerster, Arthur E H Bentlage, Marlies M van Haaren, Denise Guerra, Judith A Burger, Edith E Schermer, Kirsten D Verheul, Niels van der Velde, Alex van der Kooi, Jelle van Schooten, Mariëlle J van Breemen, Tom P L Bijl, Kwinten Sliepen, Aafke Aartse, Ronald Derking, Ilja Bontjer, Neeltje A Kootstra, W Joost Wiersinga, Gestur Vidarsson, Bart L Haagmans, Andrew B Ward, Godelieve J de Bree, Rogier W Sanders, Marit J van Gils
The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has had a large impact on global health, travel, and economy. Therefore, preventative and therapeutic measures are urgently needed. Here, we isolated monoclonal antibodies from three convalescent coronavirus disease 2019 (COVID-19) patients using a SARS-CoV-2 stabilized prefusion spike protein. These antibodies had low levels of somatic hypermutation and showed a strong enrichment in VH1-69, VH3-30-3, and VH1-24 gene usage. A subset of the antibodies was able to potently inhibit authentic SARS-CoV-2 infection at a concentration as low as 0...
August 7, 2020: Science
#33
JOURNAL ARTICLE
S J van de Hei, B M J Flokstra-de Blok, H J Baretta, N E Doornewaard, T van der Molen, K W Patberg, E C M Ruberg, T R J Schermer, I Steenbruggen, J W K van den Berg, J W H Kocks
American and European societies' (ATS/ERS) criteria for spirometry are often not met in primary care. Yet, it is unknown if quality is sufficient for daily clinical use. We evaluated quality of spirometry in primary care based on clinical usefulness, meeting ATS/ERS criteria and agreement on diagnosis between general practitioners (GPs) and pulmonologists. GPs included ten consecutive spirometry tests and detailed history questionnaires of patients who underwent spirometry as part of usual care. GPs and two pulmonologists assessed the spirometry tests and questionnaires on clinical usefulness and formulated a diagnosis...
May 15, 2020: NPJ Primary Care Respiratory Medicine
#34
COMPARATIVE STUDY
Sybille Koehler, Alexander Kuczkowski, Lucas Kuehne, Christian Jüngst, Martin Hoehne, Florian Grahammer, Sean Eddy, Matthias Kretzler, Bodo B Beck, Jörg Höhfeld, Bernhard Schermer, Thomas Benzing, Paul T Brinkkoetter, Markus M Rinschen
BACKGROUND: Understanding podocyte-specific responses to injury at a systems level is difficult because injury leads to podocyte loss or an increase of extracellular matrix, altering glomerular cellular composition. Finding a window into early podocyte injury might help identify molecular pathways involved in the podocyte stress response. METHODS: We developed an approach to apply proteome analysis to very small samples of purified podocyte fractions. To examine podocytes in early disease states in FSGS mouse models, we used podocyte fractions isolated from individual mice after chemical induction of glomerular disease (with Doxorubicin or LPS)...
March 2020: Journal of the American Society of Nephrology: JASN
#35
JOURNAL ARTICLE
R S Nannan Panday, S Wang, E H Schermer, T Cooksley, N Alam, P W B Nanayakkara
BACKGROUND: Sepsis in patients with cancer is increasingly common and associated with high mortality. To date, no studies have examined the effectiveness of prehospital antibiotics in septic patients with cancer. This study aimed without and to evaluate the effect of prehospital antibiotics in septic patients with cancer. METHODS: We conducted a post-hoc sub-analysis of the PHANTASi (PreHospital ANTibioitcs Against Sepsis) trial database: a randomised controlled trial which enrolled patients with suspected sepsis who were transported to the emergency department by ambulance...
February 2020: Netherlands Journal of Medicine
#36
JOURNAL ARTICLE
Kwinten Sliepen, Byung Woo Han, Ilja Bontjer, Petra Mooij, Fernando Garces, Anna-Janina Behrens, Kimmo Rantalainen, Sonu Kumar, Anita Sarkar, Philip J M Brouwer, Yuanzi Hua, Monica Tolazzi, Edith Schermer, Jonathan L Torres, Gabriel Ozorowski, Patricia van der Woude, Alba Torrents de la Peña, Mariëlle J van Breemen, Juan Miguel Camacho-Sánchez, Judith A Burger, Max Medina-Ramírez, Nuria González, Jose Alcami, Celia LaBranche, Gabriella Scarlatti, Marit J van Gils, Max Crispin, David C Montefiori, Andrew B Ward, Gerrit Koopman, John P Moore, Robin J Shattock, Willy M Bogers, Ian A Wilson, Rogier W Sanders
Stabilized HIV-1 envelope glycoproteins (Env) that resemble the native Env are utilized in vaccination strategies aimed at inducing broadly neutralizing antibodies (bNAbs). To limit the exposure of rare isolate-specific antigenic residues/determinants we generated a SOSIP trimer based on a consensus sequence of all HIV-1 group M isolates (ConM). The ConM trimer displays the epitopes of most known bNAbs and several germline bNAb precursors. The crystal structure of the ConM trimer at 3.9 Å resolution resembles that of the native Env trimer and its antigenic surface displays few rare residues...
May 29, 2019: Nature Communications
#37
JOURNAL ARTICLE
B E Atkinson, J A Schermer, R A Martin, N G Martin, M T Lynskey, T J Trull, P A Vernon
No abstract text is available yet for this article.
May 2, 2019: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
#38
JOURNAL ARTICLE
Paul T Brinkkoetter, Tillmann Bork, Sarah Salou, Wei Liang, Athanasia Mizi, Cem Özel, Sybille Koehler, H Henning Hagmann, Christina Ising, Alexander Kuczkowski, Svenia Schnyder, Ahmed Abed, Bernhard Schermer, Thomas Benzing, Oliver Kretz, Victor G Puelles, Simon Lagies, Manuel Schlimpert, Bernd Kammerer, Christoph Handschin, Christoph Schell, Tobias B Huber
The cellular responses induced by mitochondrial dysfunction remain elusive. Intrigued by the lack of almost any glomerular phenotype in patients with profound renal ischemia, we comprehensively investigated the primary sources of energy of glomerular podocytes. Combining functional measurements of oxygen consumption rates, glomerular metabolite analysis, and determination of mitochondrial density of podocytes in vivo, we demonstrate that anaerobic glycolysis and fermentation of glucose to lactate represent the key energy source of podocytes...
April 30, 2019: Cell Reports
#39
JOURNAL ARTICLE
Manaswita Jain, Rainer W J Kaiser, Katrin Bohl, Martin Hoehne, Heike Göbel, Malte P Bartram, Sandra Habbig, Roman-Ulrich Müller, Agnes B Fogo, Thomas Benzing, Bernhard Schermer, Katja Höpker, Gisela G Slaats
Recent human genetic studies have suggested an intriguing link between ciliary signaling defects and altered DNA damage responses in nephronophthisis (NPH) and related ciliopathies. However, the molecular mechanism and the role of altered DNA damage response in kidney degeneration and fibrosis have remained elusive. We recently identified the kinase-regulated DNA damage response target Apoptosis Antagonizing Transcription Factor (AATF) as a master regulator of the p53 response. Here, we characterized the phenotype of mice with genetic deletion of Aatf in tubular epithelial cells...
April 2019: Kidney International
#40
JOURNAL ARTICLE
Martin R Späth, Malte P Bartram, Nicolàs Palacio-Escat, K Johanna R Hoyer, Cedric Debes, Fatih Demir, Christina B Schroeter, Amrei M Mandel, Franziska Grundmann, Giuliano Ciarimboli, Andreas Beyer, Jayachandran N Kizhakkedathu, Susanne Brodesser, Heike Göbel, Jan U Becker, Thomas Benzing, Bernhard Schermer, Martin Höhne, Volker Burst, Julio Saez-Rodriguez, Pitter F Huesgen, Roman-Ulrich Müller, Markus M Rinschen
Acute kidney injury (AKI) leads to significant morbidity and mortality; unfortunately, strategies to prevent or treat AKI are lacking. In recent years, several preconditioning protocols have been shown to be effective in inducing organ protection in rodent models. Here, we characterized two of these interventions-caloric restriction and hypoxic preconditioning-in a mouse model of cisplatin-induced AKI and investigated the underlying mechanisms by acquisition of multi-layered omic data (transcriptome, proteome, N-degradome) and functional parameters in the same animals...
November 29, 2018: Kidney International
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