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https://www.readbyqxmd.com/read/29786833/assessment-of-cerebral-perfusion-and-edema-in-preeclampsia-with-intravoxel-incoherent-motion-mri
#1
Maria Nelander, Daniel Hannsberger, Inger Sundström-Poromaa, Lina Bergman, Jan Weis, Helena Åkerud, Johan Wikström, Anna-Karin Wikström
INTRODUCTION: Cerebral complications are the main reasons for morbidity and mortality in preeclampsia and eclampsia. Still we do not know if the pathophysiology entails hypo- or hyperperfusion of the brain, or how and when edema emerges, due to the difficulty to examine the cerebral circulation. MATERIAL AND METHODS: We have used a non-invasive diffusion weighted magnetic resonance imaging (MRI) technique, intravoxel incoherent motion, to study cerebral perfusion on the capillary level and cerebral edema in women with preeclampsia (n=30), normal pregnancy (n=32) and non-pregnant women (n=16)...
May 22, 2018: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29766469/proteinuric-glomerulopathy-in-an-adolescent-with-a-distal-partial-trisomy-chromosome-1
#2
Takaya Sasaki, Masahiro Okabe, Takeshi Tosaki, Yu Honda, Masahiro Ishikawa, Nobuo Tsuboi, Takashi Yokoo
We report a case of distal partial trisomy 1 from q32.1 to 41 that have exhibited proteinuric glomerulopathy. The patient was a 17-year-old adolescent with clinical features of low birth weight, mild mental retardation and mild deafness, from the birth. He exhibited non-nephrotic range proteinuria with the mild obesity since the age of sixteen. Image studies did not reveal morphological abnormalities of the kidneys. Renal biopsy findings showed no definitive evidence of primary glomerular diseases, and were characterized by a very low glomerular density, glomerulomegaly and focal effacement of podocyte foot processes...
May 16, 2018: CEN Case Reports
https://www.readbyqxmd.com/read/29760312/change-in-cerebral-blood-flow-after-palliative-percutaneous-angioplasty-and-timing-of-second-stage-carotid-artery-stenting-in-staged-angioplasty
#3
Hisashi Nagashima, Kazuhiro Hongo, Alhusain Nagm
The purpose of this study is to elucidate the hemodynamic changes after palliative angioplasty and the timing of second stage carotid artery stenting (CAS) in staged angioplasty for patients with severe hemodynamically compromised carotid artery stenosis. Among consecutive 111 patients with carotid artery stenosis, chronological changes in the cerebral blood flow of all 11 hemodynamically compromised patients treated with CAS were evaluated with single photon emission computed tomogram (SPECT) in each stage of the treatment...
May 11, 2018: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/29757425/four-dimensional-flow-mri-analysis-of-cerebral-blood-flow-before-and-after-high-flow-extracranial-intracranial-bypass-surgery-with-internal-carotid-artery-ligation
#4
Erika Orita, Yasuo Murai, Tetsuro Sekine, Ryo Takagi, Yasuo Amano, Takahiro Ando, Kotomi Iwata, Makoto Obara, Shinichiro Kumita
BACKGROUND: The hemodynamic changes that occur after high-flow (extracranial-intracranial) EC-IC bypass surgery with internal carotid artery (ICA) ligation are not well known. OBJECTIVE: To assess blood flow changes after high-flow EC-IC bypass with ICA ligation by time-resolved 3-dimensional phase-contrast (4D Flow) magnetic resonance imaging (MRI). METHODS: We enrolled 11 patients who underwent high-flow EC-IC bypass. 4D Flow MRI was performed before and after surgery to quantify the blood flow volume (BFV) of the ipsilateral ICA (BFViICA), bypass artery (BFVbypass), contralateral ICA (BFVcICA), and basilar artery (BFVBA)...
May 11, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29751289/perfusion-alterations-converge-with-patterns-of-pathological-spread-in-transactive-response-dna-binding-protein-43-proteinopathies
#5
Pilar M Ferraro, Charles Jester, Christopher A Olm, Katerina Placek, Federica Agosta, Lauren Elman, Leo McCluskey, David J Irwin, John A Detre, Massimo Filippi, Murray Grossman, Corey T McMillan
Amyotrophic lateral sclerosis (ALS) and the behavioral variant of frontotemporal dementia (bvFTD) commonly share the presence of transactive response DNA-binding protein 43 (TDP-43) inclusions. Structural magnetic resonance imaging studies demonstrated evidence for TDP-43 pathology spread, but while structural imaging usually reveals overt neuronal loss, perfusion imaging may detect more subtle neural activity alterations. We evaluated perfusion as an early marker for incipient pathology-associated brain alterations in TDP-43 proteinopathies...
April 17, 2018: Neurobiology of Aging
https://www.readbyqxmd.com/read/29729468/the-angiography-of-cervical-carotid-plaque-rupture-due-to-percutaneus-transluminal-balloon-arterioplasty
#6
Tomoya Omae, Naomoto Senbokuya, Toshiharu Yanagisawa
The authors describe the rare imaging of plaque rupture at cervical internal carotid artery stenosis after balloon-arterioplasty. The patient was 82 year-old male who was complained of lt. hemiparesis. Magnetic Resonance imaging-diffusion weight imaging revealed multiple high signal intensity at rt. cerebral hemisphere. Magnetic Resonance angiography showed severe stenosis at cervical internal carotid artery. We considered high risk of hyperperfusion syndrome after revascularization. We planned staged angioplasty...
May 2, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29726017/effect-of-cerebral-flow-autoregulation-function-on-cerebral-flow-rate-under-continuous-flow-left-ventricular-assist-device-support
#7
Selim Bozkurt
Neurological complications in continuous flow left ventricular assist device (CF-LVAD) patients are the second-leading risk of death after multi-organ failure. They are associated with altered blood flow in the cardiovascular system because of CF-LVAD support. Moreover, an impaired cerebral autoregulation function may also contribute to complications such as hyperperfusion in the cerebral circulation under mechanical circulatory support. The aim of this study is to evaluate the effect of cerebral autoregulatory function on cerebral blood flow rate under CF-LVAD support...
May 3, 2018: Artificial Organs
https://www.readbyqxmd.com/read/29689406/hyperperfusion-syndrome-after-trapping-with-high-flow-bypass-for-a-giant-paraclinoid-internal-carotid-artery-aneurysm
#8
Masanao Mohri, Toshiya Ichinose, Naoyuki Uchiyama, Kouichi Misaki, Iku Nambu, Yasushi Takabatake, Mitsutoshi Nakada
BACKGROUND: Hyperperfusion syndrome associated with aneurysm surgery is rare. The occurrence of the syndrome after trapping with high-flow bypass has not been described previously. Herein, we present a case of the syndrome occurring after trapping with high-flow bypass of an unruptured giant paraclinoid internal carotid artery (ICA) aneurysm. CASE DESCRIPTION: The patient was a 68-year-old woman with progressive loss of vision in her left eye. After a diagnosis of a left giant ICA aneurysm, she underwent successful trapping with high-flow bypass...
April 21, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29685407/staged-carotid-artery-stenting-in-patients-with-severe-carotid-stenosis-multicenter-experience
#9
Dong Hyun Yoo, Hong Gee Roh, See-Sung Choi, Jusun Moon, Jeongjun Lee, Young Dae Cho, Moon Hee Han, Keun-Hwa Jung, Byung-Woo Yoon, Hyun-Seung Kang
Cerebral hyperperfusion syndrome (CHS) is serious complication after carotid artery stenting (CAS) caused by decreased cerebral vasoreactivity (CVR) due to long standing hypoperfusion of the brain. We hypothesized that partial dilatation of carotid stenosis would allow the recovery of CVR, and prevent CHS when definitive angioplasty with stent is performed afterward. In this study, we aimed to evaluate the safety and efficacy of staged CAS in patients with severe carotid artery stenosis with evident hemodynamic compromise in regard to preventing hyperperfusion syndrome...
April 20, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29677060/cerebral-small-vessel-but-not-large-vessel-disease-is-associated-with-impaired-cerebral-autoregulation-during-cardiopulmonary-bypass-a-retrospective-cohort-study
#10
Yohei Nomura, Roland Faegle, Daijiro Hori, Abbas Al-Qamari, Alexander J Nemeth, Rebecca Gottesman, Gayane Yenokyan, Charles Brown, Charles W Hogue
BACKGROUND: Impaired cerebral blood flow (CBF) autoregulation during cardiopulmonary bypass (CPB) is associated with stroke and other adverse outcomes. Large and small arterial stenosis is prevalent in patients undergoing cardiac surgery. We hypothesize that large and/or small vessel cerebral arterial disease is associated with impaired cerebral autoregulation during CPB. METHODS: A retrospective cohort analysis of data from 346 patients undergoing cardiac surgery with CPB enrolled in an ongoing prospectively randomized clinical trial of autoregulation monitoring were evaluated...
April 17, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29668855/the-negative-ultraslow-potential-electrophysiological-correlate-of-infarction-in-the-human-cortex
#11
Janos Lückl, Coline L Lemale, Vasilis Kola, Viktor Horst, Uldus Khojasteh, Ana I Oliveira-Ferreira, Sebastian Major, Maren K L Winkler, Eun-Jeung Kang, Karl Schoknecht, Peter Martus, Jed A Hartings, Johannes Woitzik, Jens P Dreier
Spreading depolarizations are characterized by abrupt, near-complete breakdown of the transmembrane ion gradients, neuronal oedema, mitochondrial depolarization, glutamate excitotoxicity and activity loss (depression). Spreading depolarization induces either transient hyperperfusion in normal tissue; or hypoperfusion (inverse coupling = spreading ischaemia) in tissue at risk for progressive injury. The concept of the spreading depolarization continuum is critical since many spreading depolarizations have intermediate characteristics, as opposed to the two extremes of spreading depolarization in either severely ischaemic or normal tissue...
April 16, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29663353/positron-emission-tomography-imaging-of-cerebral-glucose-metabolism-and-type-1-cannabinoid-receptor-availability-during-temporal-lobe-epileptogenesis-in-the-amygdala-kindling-model-in-rhesus-monkeys
#12
Evy Cleeren, Cindy Casteels, Karolien Goffin, Michel Koole, Koen Van Laere, Peter Janssen, Wim Van Paesschen
OBJECTIVE: We investigated changes in the endocannabinoid system and glucose metabolism during temporal lobe epileptogenesis. METHODS: Because it is rarely possible to study epileptogenesis in humans, we applied the electrical amygdala kindling model in nonhuman primates to image longitudinal changes in type 1 cannabinoid receptor (CB1R) binding and cerebral glucose metabolism. Two rhesus monkeys received [18 F]-MK-9470 and fluorodeoxyglucose-positron emission tomography ([18 F]-FDG -PET) scans in each of the 4 kindling stages to quantify relative changes over time of CB1R binding and cerebral glucose metabolism in vivo...
April 17, 2018: Epilepsia
https://www.readbyqxmd.com/read/29661465/allograft-portacaval-shunt-in-small-for-size-liver-in-deceased-donor-liver-transplant
#13
J H Nguyen, D M Harnois
Portal hyperperfusion is detrimental to small-for-size livers (SFSLs) in liver transplantation. Surgical techniques modulating portal inflow provide the most effective approach to protect the SFSL. In this report, we describe a technique creating an allograft portacaval shunt that effectively attenuates portal inflow without a requirement of extensive surgical dissection in the recipient during the transplantation.
April 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29643681/mismatch-in-brain-perfusion-and-metabolism-detected-with-99m-tc-hexamethyl-propylene-amine-oxime-single-photon-emission-computed-tomography-and-18-f-fluorodeoxyglucose-positron-emission-tomography-in-moyamoya-disease
#14
Justo Serrano Vicente, Luis Fernández Prudencio, José Rafael Infante Torre, Juan Ignacio Rayo Madrid
We report a 47-year-old woman who developed an ischemic stroke with diplopia and dysarthria. Emergency computed tomography (CT) showed no pathological findings, and magnetic resonance (MR) showed mild ischemic-degenerative lesions. MR angiography and angiogram showed severe stenosis of both internal carotid and main intracranial arteries with plenty collateral vessels with "puff of smoke" suggesting a moyamoya disease (MMD). Brain perfusion single-photon emission CT showed global diminished perfusion in the brain lobes and a marked relative hyperperfusion in the cerebellum...
April 2018: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/29629988/early-evidence-of-sepsis-associated-hyperperfusion-a-study-of-cerebral-blood-flow-measured-with-mri-arterial-spin-labeling-in-critically-ill-septic-patients-and-control-subjects
#15
Marie-Hélène Masse, Marie Anne Richard, Frédérick D'Aragon, Charles St-Arnaud, Michael Mayette, Neill K J Adhikari, William Fraser, André Carpentier, Steven Palanchuck, David Gauthier, Luc Lanthier, Matthieu Touchette, Albert Lamontagne, Jean Chénard, Sangeeta Mehta, Yanick Sansoucy, Etienne Croteau, Martin Lepage, François Lamontagne
OBJECTIVES: Mechanisms underlying sepsis-associated encephalopathy remain unclear, but reduced cerebral blood flow, alone or in conjunction with altered autoregulation, is reported as a potential contributor. We compared cerebral blood flow of control subjects and vasopressor-dependent septic patients. DESIGN: Randomized crossover study. SETTING: MRI with arterial spin labeling. PATIENTS: Ten sedated septic patients on mechanical ventilation (four with controlled chronic hypertension) and 12 control subjects (six with controlled chronic hypertension) were enrolled...
April 6, 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29626683/assessment-of-hemodynamic-changes-and-hyperperfusion-risk-following-extracranial-to-intracranial-bypass-surgery-using-intraoperative-indocyanine-green-based-flow-analysis
#16
Robert C Rennert, Ben A Strickland, Kristina Ravina, Joshua Bakhsheshian, Jonathan J Russin
BACKGROUND: Intra-operative blood flow assessments during cerebral bypass would ideally assess vessel patency, downstream perfusion, and risk of post-operative hyperperfusion syndrome (HPS). Previous studies using Indocyanine Green-based flow analyses (ICG-BFA) have identified multiple parameters that can intra-operatively track bypass-related changes in cerebral perfusion and potentially predict post-operative HPS risk. Herein, we determine the most robust parameter and anatomic location for intra-operative ICG-BFA assessment of bypass-related perfusion changes and prediction of post-operative HPS risk...
April 4, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29622356/risk-and-outcome-profile-of-carotid-endarterectomy-with-proximal-intervention-is-concerning-in-multi-institutional-assessment
#17
W Darrin Clouse, Emel A Ergul, Zachary J Wanken, Julia Kleene, David H Stone, R Clement Darling, Richard P Cambria, Mark F Conrad
OBJECTIVE: Approaching tandem bifurcation and brachiocephalic disease using carotid endarterectomy (CEA) with ipsilateral proximal endovascular intervention (IPE) has been promulgated as safe and durable. There have been recent concerns about neurologic risk with this technique. The goal of this study was to define stroke and perioperative risk with this uncommon procedure across multiple centers. METHODS: Between August 2002 and July 2016, patients who underwent CEA + IPE were identified by operative records at three institutions...
April 2, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29620006/electroclinical-and-radiological-observation-of-dysfunctional-zones-in-a-patient-with-neurosyphilis
#18
Katsuya Sakai, Shogo Yazawa, Akiko Sugimoto, Koichi Nakao, Kazuhito Tsuruta, Eiji Ochiai, Yukiko Suzuki, Masao Matsuhashi
We report a 33-year-old Japanese man who suffered from repetitive generalized tonic-clonic seizures which were medically intractable. Neurosyphilis was serologically diagnosed in blood and cerebrospinal fluid, and penicillin G (PcG) was consequently effective. The EEG during PcG pre-treatment showed frequent right occipital spikes and right frontocentral slow waves, which disappeared after treatment. During pre-treatment, positron emission tomography with 18-fluorodeoxyglucose and Tc-99m ethyl cysteinate dimer single-photon emission computed tomography revealed occipital hypermetabolism and hyperperfusion ("hot" area) and fronto-temporo-parietal hypometabolism and hypoperfusion ("cool" area) over the right hemisphere...
April 5, 2018: Epileptic Disorders: International Epilepsy Journal with Videotape
https://www.readbyqxmd.com/read/29610036/paradoxical-association-of-symptomatic-local-vasogenic-edema-with-global-cerebral-hypoperfusion-after-direct-revascularization-surgery-for-adult-moyamoya-disease
#19
Ryosuke Tashiro, Miki Fujimura, Shunji Mugikura, Kuniyasu Niizuma, Hidenori Endo, Toshiki Endo, Teiji Tominaga
BACKGROUND: Superficial temporal artery-middle cerebral artery (STA-MCA) anastomosis is the standard treatment for Moyamoya disease (MMD). Cerebral hyperperfusion syndrome is a potential complication of this procedure and can cause local vasogenic edema and/or delayed intracerebral hemorrhage. Cerebral hypoperfusion is a contradictory postoperative pathophysiological condition implicated in MMD, but its association with symptomatic local vasogenic edema has not been reported. CASE REPORT: A 31-year-old woman with MMD underwent left STA-MCA anastomosis 3 months after a minor completed stroke in bilateral hemispheres...
March 30, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29600916/risk-factors-for-and-outcomes-of-postoperative-complications-in-adult-patients-with-moyamoya-disease
#20
Meng Zhao, Xiaofeng Deng, Dong Zhang, Shuo Wang, Yan Zhang, Rong Wang, Jizong Zhao
OBJECTIVE The risk factors and clinical significance of postoperative complications in moyamoya disease are still unclear. The aim of this study was to investigate the predictors of postoperative complications in moyamoya disease and examine the impact of complications on outcomes. METHODS The authors reviewed consecutive cases involving adult moyamoya disease patients who underwent indirect, direct, or combined bypass surgery in their hospital between 2009 and 2015. Preoperative clinical characteristics and radiographic features were recorded...
March 30, 2018: Journal of Neurosurgery
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