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Ang 2 AND nitric oxide

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https://www.readbyqxmd.com/read/28905315/preliminary-studies-of-acute-cadmium-administration-effects-on-the-calcium-activated-potassium-skca-and-bkca-channels-and-na-k-atpase-activity-in-isolated-aortic-rings-of-rats
#1
Dalton V Vassallo, Camila C P Almenara, Gilson Brás Broseghini-Filho, Ariane Calazans Teixeira, David Chaves F da Silva, Jhuli K Angeli, Alessandra S Padilha
Cadmium is an environmental pollutant closely linked with cardiovascular diseases that seems to involve endothelium dysfunction and reduced nitric oxide (NO) bioavailability. Knowing that NO causes dilatation through the activation of potassium channels and Na(+)/K(+)-ATPase, we aimed to determine whether acute cadmium administration (10 μM) alters the participation of K(+) channels, voltage-activated calcium channel, and Na(+)/K(+)-ATPase activity in vascular function of isolated aortic rings of rats. Cadmium did not modify the acetylcholine-induced relaxation...
September 13, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28878301/epa-dha-6-1-prevents-angiotensin-ii-induced-hypertension-and-endothelial-dysfunction-in-rats-role-of-nadph-oxidase-and-cox-derived-oxidative-stress
#2
Zahid Rasul Niazi, Grazielle C Silva, Thais Porto Ribeiro, Antonio J León-González, Mohamad Kassem, Abdur Mirajkar, Azhar Alvi, Malak Abbas, Faraj Zgheel, Valérie B Schini-Kerth, Cyril Auger
Eicosapentaenoic acid:docosahexaenoic acid (EPA:DHA) 6:1, an omega-3 polyunsaturated fatty acid formulation, has been shown to induce a sustained formation of endothelial nitric oxide (NO) synthase-derived NO, a major vasoprotective factor. This study examined whether chronic intake of EPA:DHA 6:1 prevents hypertension and endothelial dysfunction induced by angiotensin II (Ang II) in rats. Male Wister rats received orally corn oil or EPA:DHA 6:1 (500 mg kg(-1) per day) before chronic infusion of Ang II (0...
September 7, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/28875323/evodiamine-inhibits-angiotensin-ii-induced-rat-cardiomyocyte-hypertrophy
#3
Na He, Qi-Hai Gong, Feng Zhang, Jing-Yi Zhang, Shu-Xian Lin, Hua-Hua Hou, Qin Wu, An-Sheng Sun
OBJECTIVE: To investigate the effects of evodiamine (Evo), a component of Evodiaminedia rutaecarpa Juss.) Benth, on cardiomyocyte hypertrophy induced by angiotensin II (Ang II) and further explore the potential mechanisms. METHODS: Cardiomyocytes from neonatal Sprague Dawley rats were isolated and characterized, and then the cadiomyocyte cultures were randomly divided into control, model (Ang II 0.1 μmol/L), and Evo (0.03, 0.3, 3 μmol/L) groups. The cardiomyocyte surface area, protein level, intracellular free calcium ([Ca(2+)]i) concentration, activity of nitric oxide synthase (NOS) and content of nitric oxide (NO) were measured, respectively...
September 5, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28861607/glomerular-and-tubular-effects-of-nitric-oxide-no-are-regulated-by-angiotensin-ii-ang-ii-in-an-age-dependent-manner-through-activation-of-both-angiotensin-receptors-at1rs-and-at2rs-in-conscious-lambs
#4
Angela E Vinturache, Francine G Smith
Renin-angiotensin (RAS) and nitric oxide (NO) systems and the balance and interaction between them are considered of primary importance in maintaining fluid and electrolyte homeostasis. It has been suggested that the effects of NO may be modulated at least in part by the angiotensin (Ang) II, yet the roles of angiotensin receptor type 1 (AT1R) and type 2 (AT2R) are not well understood. Even though both Ang II and NO are elevated at birth and during the newborn period, their contribution to the adaptation of the newborn to life after birth as well as their physiological roles during development are poorly understood...
August 31, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/28840773/prorenin-receptor-prr-mediated-nadph-oxidase-nox-signaling-regulates-vegf-synthesis-under-hyperglycemic-condition-in-arpe-19-cells
#5
Rashidul Haque, P Michael Iuvone, Li He, Elizabeth H Hur, Kimberly Su Chung Choi, Daniel Park, Annie N Farrell, Ashley Ngo, Samantha Gokhale, Madiha Aseem, Bhavna Kumar
The stimulation of angiotensin II (Ang II), the effector peptide of renin-angiotensin system, has been reported to increase the expression of vascular endothelial growth factor (VEGF) through the activation of the Ang II type 1 receptor (AT1R). In this study, we investigated whether hyperglycemia (HG, 33 mM glucose) in ARPE-19 cells could promote the expression of VEGF independently of Ang II through prorenin receptor (PRR), via an NADPH oxidase (Nox)-dependent mechanism. ARPE-19 cells were treated with the angiotensin converting enzyme (ACE) inhibitor perindopril to block the synthesis of Ang II...
August 25, 2017: Journal of Receptor and Signal Transduction Research
https://www.readbyqxmd.com/read/28710069/vitamin-c-mitigates-oxidative-nitrosative-stress-and-inflammation-in-doxorubicin-induced-cardiomyopathy
#6
Gauri Akolkar, Danielle da Silva Dias, Prathapan Ayyappan, Ashim K Bagchi, Davinder S Jassal, Vera Mc Salemi, Maria Claudia Irigoyen, Katia De Angelis, Pawan K Singal
Increase in oxidative/nitrosative stress is one of the mechanisms associated with the development of cardiotoxicity due to Doxorubicin (Dox), a potent chemotherapy drug. Previously, we reported mitigation of Dox-induced oxidative/nitrosative stress and apoptosis by Vitamin C (Vit C) in isolated cardiomyocytes. In the present in vivo study in rats, we investigated the effect of prophylactic treatment with Vit C on Dox-induced apoptosis, inflammation, oxidative/nitrosative stress, cardiac dysfunction and Vit C transporter proteins...
July 14, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28653133/dysregulation-of-cerebellar-adrenomedullin-signaling-during-hypertension
#7
Leticia Figueira, Anita Israel
Adrenomedullin (AM) is a peptide involved in blood pressure regulation. AM activates three different receptors, the AM type 1 (AM1), type 2 (AM2), and calcitonin gene-related peptide 1 (CGRP1) receptors. AM triggers several signaling pathways such as adenylyl cyclase (AC), guanylyl cyclase (GC), and extracellular signal-regulated kinases (ERK) and modulates reactive oxygen species (ROS) metabolism. Cerebellar AM, AM-binding sites, and its receptor components are altered during hypertension, although it is unknown if these alterations are associated with changes in AM signaling...
August 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/28620011/dietary-restriction-but-not-angiotensin-ii-type-1-receptor-blockade-improves-dna-damage-related-vasodilator-dysfunction-in-rapidly-aging-ercc1-%C3%AE-mice
#8
Haiyan Wu, Bibi S van Thiel, Paula K Bautista-Niño, Erwin Reiling, Matej Durik, Frank P J Leijten, Yanto Ridwan, Renata M C Brandt, Harry van Steeg, Martijn E T Dollé, Wilbert P Vermeij, Jan H J Hoeijmakers, Jeroen Essers, Ingrid van der Pluijm, A H Jan Danser, Anton J M Roks
DNA damage is an important contributor to endothelial dysfunction and age-related vascular disease. Recently, we demonstrated in a DNA repair-deficient, prematurely aging mouse model (Ercc1(Δ/-) mice) that dietary restriction (DR) strongly increases life- and health span, including ameliorating endothelial dysfunction, by preserving genomic integrity. In this mouse mutant displaying prominent accelerated, age-dependent endothelial dysfunction we investigated the signaling pathways involved in improved endothelium-mediated vasodilation by DR, and explore the potential role of the renin-angiotensin system (RAS)...
August 1, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28554983/cyp2j2-metabolites-epoxyeicosatrienoic-acids-attenuate-ang-ii-induced-cardiac-fibrotic-response-by-targeting-g%C3%AE-12-13
#9
Zuowen He, Yong Yang, Zheng Wen, Chen Chen, Xizhen Xu, Yanfang Zhu, Yan Wang, Dao Wen Wang
The arachidonic acid-cytochrome P450 2J2-epoxyeicosatrienoic acid (AA-CYP2J2-EET) metabolic pathway has been identified to be protective in the cardiovascular system. This study explored the effects of the AA-CYP2J2-EET metabolic pathway on cardiac fibrosis from the perspective of cardiac fibroblasts and underlying mechanisms. In in vivo studies, 8-week-old male CYP2J2 transgenic mice (aMHC-CYP2J2-Tr) and littermates were infused with angiotensin II (Ang II) or saline for 2 weeks. Results showed that CYP2J2 overexpression increased EET production...
July 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28534086/neuronal-nitric-oxide-synthase-modulation-of-intracellular-ca-2-handling-overrides-fatty-acid-potentiation-of-cardiac-inotropy-in-hypertensive-rats
#10
Chun Li Jin, Ming Zhe Yin, Jin Chul Paeng, Seunggyun Ha, Jeong Hoon Lee, Peng Jin, Chun Zi Jin, Zai Hao Zhao, Yue Wang, Keon Wook Kang, Chae Hun Leem, Jong-Wan Park, Sung Joon Kim, Yin Hua Zhang
Cardiac neuronal nitric oxide synthase (nNOS) is an important molecule that regulates intracellular Ca(2+) homeostasis and contractility of healthy and diseased hearts. Here, we examined the effects of nNOS on fatty acid (FA) regulation of left ventricular (LV) myocyte contraction in sham and angiotensin II (Ang II)-induced hypertensive (HTN) rats. Our results showed that palmitic acid (PA, 100 μM) increased the amplitudes of sarcomere shortening and intracellular ATP in sham but not in HTN despite oxygen consumption rate (OCR) was increased by PA in both groups...
May 22, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/28443955/a-single-resistance-exercise-session-improves-aortic-endothelial-function-in-hypertensive-rats
#11
Thaís de Oliveira Faria, Jhuli Keli Angeli, Luiz Guilherme Marchesi Mello, Gustavo Costa Pinto, Ivanita Stefanon, Dalton Valentim Vassallo, Juliana Hott de Fúcio Lizardo
BACKGROUND: Physical exercise is an important tool for the improvement of endothelial function. OBJECTIVE: To assess the effects of acute dynamic resistance exercise on the endothelial function of spontaneously hypertensive rats (SHR). METHODS: Ten minutes after exercise, the aorta was removed to evaluate the expression of endothelial nitric oxide synthase (eNOS), phosphorylated endothelial nitric oxide synthase (p-eNOS1177) and inducible nitric oxide synthase (iNOS) and to generate concentration-response curves to acetylcholine (ACh) and to phenylephrine (PHE)...
March 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28282029/distribution-of-pericellular-matrix-molecules-in-the-temporomandibular-joint-and-their-chondroprotective-effects-against-inflammation
#12
Wern Cui Chu, Shipin Zhang, Timothy J Sng, Yu Jie Ong, Wen-Li Tan, Vivien Y Ang, Casper B Foldager, Wei Seong Toh
The objectives of this study were to (1) determine the distribution and synthesis of pericellular matrix (PCM) molecules (collagen VI, collagen IV and laminin) in rat temporomandibular joint (TMJ) and (2) investigate the effects of PCM molecules on chondrocytes against inflammation in osteoarthritis. Four zones (fibrous, proliferating, mature and hypertrophic) of condylar cartilage and three bands (anterior, intermediate and posterior) of disc were analysed by immunohistochemistry for the presence of PCM molecules in rat TMJs...
March 2017: International Journal of Oral Science
https://www.readbyqxmd.com/read/28218456/endothelial-cells-inhibit-the-angiotensin-ii-induced-phenotypic-modulation-of-rat-vascular-adventitial-fibroblasts
#13
Jia-Ying Xu, Neng-Bin Chang, Tao Li, Rui Jiang, Xiao-Lei Sun, Yan-Zheng He, Jun Jiang
The phenotypic modulation of vascular adventitial fibroblasts plays an important role in vascular remodeling. Evidence have shown that endothelial cells and adventitial fibroblasts interact under certain conditions. In this study, we investigated the influence of endothelial cells on the phenotypic modulation of adventitial fibroblasts. Endothelial cells and adventitial fibroblasts from rat thoracic aorta were cultivated in a co-culture system and adventitial fibroblasts were induced with angiotensin II (Ang II)...
February 20, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28160390/angiotensin-ii-type-ii-receptors-and-colonic-dysmotility-in-2-4-dinitrofluorobenzenesulfonic-acid-induced-colitis-in-rats
#14
M G Zizzo, M Auteri, A Amato, G Caldara, D Nuzzo, M Di Carlo, R Serio
BACKGROUND: Angiotensin II (Ang II), the main peptide of the renin-angiotensin system (RAS), has been suggested to be involved in inflammatory bowel diseases. Since RAS has emerged as gut motility regulator, and dysmotility is associated with intestinal inflammation, our objective was to investigate in rat 2,4-dinitrobenzenesulfonic acid (DNBS)-induced colitis the functionality of RAS and its contribution to colonic motor alterations. METHODS: The effects of Ang II on the longitudinal colonic muscular contractility of control and DNBS-treated rats were characterized in vitro...
June 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28131844/mas-receptor-is-involved-in-the-estrogen-receptor-induced-nitric-oxide-dependent-vasorelaxation
#15
Agua Sobrino, Susana Vallejo, Susana Novella, Macarena Lázaro-Franco, Ana Mompeón, Carlos Bueno-Betí, Thomas Walther, Carlos Sánchez-Ferrer, Concepción Peiró, Carlos Hermenegildo
The Mas receptor is involved in the angiotensin (Ang)-(1-7) vasodilatory actions by increasing nitric oxide production (NO). We have previously demonstrated an increased production of Ang-(1-7) in human umbilical vein endothelial cells (HUVEC) exposed to estradiol (E2), suggesting a potential cross-talk between E2 and the Ang-(1-7)/Mas receptor axis. Here, we explored whether the vasoactive response and NO-related signalling exerted by E2 are influenced by Mas. HUVEC were exposed to 10nM E2 for 24h in the presence or absence of the selective Mas receptor antagonist A779, and the estrogen receptor (ER) antagonist ICI182780 (ICI)...
April 1, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28096047/cellular-basis-of-angiotensin-1-7-induced-augmentation-of-left-ventricular-functional-performance-in-heart-failure
#16
Xiaowei Zhang, Heng-Jie Cheng, Peng Zhou, Dalane W Kitzman, Carlos M Ferrario, Wei-Min Li, Che Ping Cheng
BACKGROUND: Angiotensin-(1-7) [Ang-(1-7)] exhibits cardiovascular effects opposite those of angiotensin II (Ang II), thus providing protection against heart disease. However, how Ang-(1-7) imparts cardioprotection is unclear, and its direct cardiac effects are controversial. Whether heart failure (HF) alters cardiac contractile responses to Ang-(1-7) remains undetermined. We tested the hypothesis that in HF, Ang-(1-7) may produce positive modulation on [Ca(2+)]i regulation, enhancing left ventricular (LV) and myocyte contraction and relaxation via Ang-(1-7) Mas receptor coupled with nitric oxide (NO)/bradykinin (BK)-mediated mechanism...
June 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28088475/role-of-some-vasoactive-mediators-in-scorpion-envenomed-children-possible-relation-to-envenoming-outcome
#17
Sahar E M El-DeeK, Ayat A Sayed, Ahmed Y Nassar, Zeynab M Mohey-Eldeen, Hussein M Eldeeb, Abdel-Raheim M A Meki
Scorpion envenomation causes an autonomic storm resulting in changes in the vasoactive mediators' levels which lead to myocardial damage, cardiovascular disturbances, peripheral circulatory failure, pulmonary edema, multi-system-organ-failure and death. The study aimed to determine the circulating levels of adrenaline, noradrenaline, angiotensin converting enzyme (ACE), Angiotensin II (Ang II), kallikrein enzyme, nitric oxide (NO), aldosterone, and electrolytes Na(+), K(+) and Ca(+2) in scorpion envenomed children and to evaluate the potential relation between these vasoactive mediators, the severity of scorpion envenoming and the clinical outcome of envenomed children...
March 1, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28052871/myoglobin-facilitates-angiotensin-ii-induced-constriction-of-renal-afferent-arterioles
#18
Z Z Liu, S Mathia, T Pahlitzsch, I C Wennysia, P B Persson, E Y Lai, A Högner, M Z Xu, R Schubert, C Rosenberger, A Patzak
Vasoconstriction plays an important role in the development of acute kidney injury in rhabdomyolysis. We hypothesized that myoglobin enhances the angiotensin II (ANG II) response in afferent arterioles by increasing superoxide and reducing nitric oxide (NO) bioavailability. Afferent arterioles of C57Bl6 mice were isolated perfused, and vasoreactivity was analyzed using video microscopy. NO bioavailability, superoxide concentration in the vessel wall, and changes in cytosolic calcium were measured using fluorescence techniques...
May 1, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28036029/fenofibrate-therapy-restores-antioxidant-protection-and-improves-myocardial-insulin-resistance-in-a-rat-model-of-metabolic-syndrome-and-myocardial-ischemia-the-role-of-angiotensin-ii
#19
Luz Ibarra-Lara, María Sánchez-Aguilar, Alicia Sánchez-Mendoza, Leonardo Del Valle-Mondragón, Elizabeth Soria-Castro, Elizabeth Carreón-Torres, Eulises Díaz-Díaz, Héctor Vázquez-Meza, Verónica Guarner-Lans, María Esther Rubio-Ruiz
Renin-angiotensin system (RAS) activation promotes oxidative stress which increases the risk of cardiac dysfunction in metabolic syndrome (MetS) and favors local insulin resistance. Fibrates regulate RAS improving MetS, type-2 diabetes and cardiovascular diseases. We studied the effect of fenofibrate treatment on the myocardic signaling pathway of Angiotensin II (Ang II)/Angiotensin II type 1 receptor (AT1) and its relationship with oxidative stress and myocardial insulin resistance in MetS rats under heart ischemia...
December 28, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27983965/cyanidin-3-glucoside-attenuates-angiotensin-ii-induced-oxidative-stress-and-inflammation-in-vascular-endothelial-cells
#20
Sivanan Sivasinprasasn, Rungusa Pantan, Sarinthorn Thummayot, Jiraporn Tocharus, Apichart Suksamrarn, Chainarong Tocharus
Angiotensin II (Ang II) causes oxidative stress and vascular inflammation, leading to vascular endothelial cell dysfunction, and is associated with the development of inflammatory cardiovascular diseases such as atherosclerosis. Therefore, interventions of oxidative stress and inflammation may contribute to the reduction of cardiovascular diseases. Cyanidin-3-glucoside (C3G) plays a role in the prevention of oxidative damage in several diseases. Here, we investigated the effect of C3G on Ang II-induced oxidative stress and vascular inflammation in human endothelial cells (EA...
October 28, 2016: Chemico-biological Interactions
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