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https://www.readbyqxmd.com/read/29441887/effect-of-npm1-type-b-mutation-on-the-proliferation-invasion-and-chemosensitivity-of-thp-1-leukemia-cells
#1
Jie Peng, Bin Fu, Gan Fu, Xielan Zhao, Xiaolin Li, Fangping Chen
Acute myeloid leukemia (AML) is the most malignant myeloid disorder in adults. AML with mutated nucleophosmin (NPM1) is regarded as an independent leukemia subtype. According to previous studies, the role of NPM1 gene A mutation in AML has been well established; however, another major type, NPM1 gene B type mutation (NPM1 MutB) has been rarely reported. In the present study, we found that overexpression of NPM1 MutB enhanced the proliferation and invasion of THP-1 AML cells through the regulation of TIMP-2, MMP-2, Ang-1, c-myc and CCND1; led to no significant change of apoptosis rate with the absence of chemotherapy agents, while enhanced the chemosensitivity of THP-1 AML cells to chemotherapy agents DNR and Ara-C through the regulation of Bax, Bcl-2 and caspase-3...
October 1, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29433675/plant-natural-product-plumbagin-presents-potent-inhibitory-effect-on-human-cytochrome-p450-2j2-enzyme
#2
Jian Lu, Daozhi Liu, Xiaojing Zhou, Ang Chen, Zhenran Jiang, Xiyun Ye, Mingyao Liu, Xin Wang
BACKGROUND: Cytochrome P450 2J2 (CYP2J2) is not only highly expressed in many kinds of human tumors, but also promotes tumor cell growth via regulating the metabolism of arachidonic acids. CYP2J2 inhibitors can significantly reduce proliferation, migration and promote apoptosis of tumor cells by inhibiting epoxyeicosatrienoic acids (EETs) biosynthesis. Therefore screening CYP2J2 inhibitors is a significant way for the development of anti-cancer drug. PURPOSE: The aim of this study was to identify a new CYP2J2 inhibitor from fifty natural compounds obtained from plants...
January 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29431621/haploidentical-hsct-for-hemoglobinopathies-improved-outcomes-with-tcr%C3%AE-%C3%AE-cd19-depleted-grafts
#3
Javid Gaziev, Antonella Isgrò, Pietro Sodani, Katia Paciaroni, Gioia De Angelis, Marco Marziali, Michela Ribersani, Cecilia Alfieri, Alessandro Lanti, Tiziana Galluccio, Gaspare Adorno, Marco Andreani
We examined outcomes of haploidentical hematopoietic cell transplantation (haplo-HCT) using T-cell receptor αβ + (TCRαβ + )/CD19 + -depleted grafts (TCR group, 14 patients) in children with hemoglobinopathies. Patients received a preparative regimen consisting of busulfan, thiotepa, cyclophosphamide, and antithymocyte globulin preceded by fludarabine, hydroxyurea, and azathioprine. The median follow-up among surviving patients was 3.9 years. The 5-year probabilities of overall survival (OS) and disease-free survival (DFS) were 84% and 69%, respectively...
February 13, 2018: Blood Advances
https://www.readbyqxmd.com/read/29431106/beneficial-effect-of-mas-receptor-deficiency-on-vascular-cognitive-impairment-in-the-presence-of-angiotensin-ii-type-2-receptor
#4
Akinori Higaki, Masaki Mogi, Jun Iwanami, Li-Juan Min, Hui-Yu Bai, Bao-Shuai Shan, Masayoshi Kukida, Toshifumi Yamauchi, Kana Tsukuda, Harumi Kan-No, Shuntaro Ikeda, Jitsuo Higaki, Masatsugu Horiuchi
BACKGROUND: The classical renin-angiotensin system is known as the angiotensin (Ang)-converting enzyme/Ang II/Ang type 1 receptor axis, which induces various organ damage including cognitive decline. The angiotensin-converting enzyme 2/Ang-(1-7)/Mas axis is known to exert antagonistic actions against the classical renin-angiotensin system axis in the cardiovascular system. However, its roles in the brain remain unclear. We examined possible roles of the angiotensin-converting enzyme 2/Ang-(1-7)/Mas axis in cognitive function, employing vascular cognitive impairment model mice...
February 3, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29429635/clinical-findings-after-bioresorbable-vascular-scaffold-implantation-in-an-unrestricted-cohort-of-patients-with-st-segment-elevation-myocardial-infarction-from-the-rai-registry
#5
Elisabetta Moscarella, Alfonso Ielasi, Attilio Varricchio, Maria Carmen De Angelis, Bruno Loi, Giuseppe Tarantini, Paolo Calabrò, Bernardo Cortese, Pietro Mazzarotto, Gabriele Gabrielli, Francesco Pisano, Michela Facchin, Leonardo Misuraca, Valerio Lucci, Roberto Gistri, Gabriele Tumminello, Luciano Moretti, Alessandro Colombo, Alessandro Durante, Massimo Fineschi, Davide Piraino, Maurizio Ferrario, Sebastian Coscarelli, Annamaria Nicolino, Maurizio Tespili, Donatella Corrado, Giuseppe Steffenino
BACKGROUND: The bioresorbable vascular scaffold (BVS) technology may be an appealing option in ST-segment elevation myocardial infarction (STEMI) patients. However, the available evidence on its use in this challenging subset is limited. METHODS: Registro Absorb Italiano (RAI) is a multicenter, prospective registry that aims to assess BVS performance through a 5-year follow-up of all consecutive patients who undergone at least 1 successful BVS implantation. As a part of it, a subgroup analysis in STEMI patients was performed and the outcomes of this cohort compared to the remaining population (defined as "non-STEMI") are reported here...
February 3, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29425387/intraoperative-patient-experience-and-postoperative-visual-quality-after-smile-and-lasik-in-a-randomized-paired-eye-controlled-study
#6
Iben B Damgaard, Marcus Ang, Mohamed Farook, Hla M Htoon, Jodhbir S Mehta
PURPOSE: To compare intraoperative and postoperative subjective patient experience after small incision lenticule extraction (SMILE) and femtosecond laser-assisted LASIK. METHODS: In a prospective, randomized, paired-eye, single-masked clinical trial at Singapore National Eye Centre, 70 patients were randomly treated with SMILE and LASIK in each eye. The intraoperative questionnaire was completed immediately after surgery and included light perception and levels of anxiety, fear, and discomfort...
February 1, 2018: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/29421438/in-vitro-study-of-fuz-as-a-novel-potential-therapeutic-target-in-non-small-cell-lung-cancer
#7
Minwei He, Kangqi Li, Chuanfei Yu, Bingfeng Lv, Ning Zhao, Jinhai Deng, Lulu Cao, He Huang, Ang Yin, Taiping Shi, Lu Wang
FUZ is regarded as a planar cell polarity effector that controls multiple cellular processes during vertebrate development. However, the role of FUZ in tumor biology remains poorly studied. Our purpose of this study is to discover the physiological effects and mechanism of FUZ in non-small-cell lung cancer (NSCLC) in vitro. With the help of bioinformatics analysis, we noticed that the expression level of FUZ negatively correlates with prognosis of NSCLC patients. Exogenous FUZ expression markedly promoted cell proliferation of NSCLC cells...
February 5, 2018: Life Sciences
https://www.readbyqxmd.com/read/29417337/natriuretic-peptide-receptor-c-activation-attenuates-angiotensin-ii-induced-enhanced-oxidative-stress-and-hyperproliferation-of-aortic-vascular-smooth-muscle-cells
#8
Padma Madiraju, Ekhtear Hossain, Madhu B Anand-Srivastava
We showed previously that natriuretic peptide receptor-C (NPR-C) agonist, C-ANP4-23, attenuated the enhanced expression of Giα proteins in vascular smooth muscle cells (VSMC) from spontaneously hypertensive rats (SHR) through the inhibition of enhanced oxidative stress. Since the enhanced levels of endogenous angiotensin II (Ang II) contribute to the overexpression of Giα proteins and augmented oxidative stress in VSMC from SHR, the present study was undertaken to investigate if C-ANP4-23 could also attenuate angiotensin II (Ang II)-induced oxidative stress and associated signaling...
February 7, 2018: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29416330/nanomedical-studies-of-the-restoration-of-nitric-oxide-peroxynitrite-balance-in-dysfunctional-endothelium-by-1-25-dihydroxy-vitamin-d3-clinical-implications-for-cardiovascular-diseases
#9
Alamzeb Khan, Hazem Dawoud, Tadeusz Malinski
Background: Clinical studies indicate that vitamin D3 improves circulation and may have beneficial effects in hypertension. This study uses nanomedical systems to investigate the role of 1,25-dihydroxy vitamin D3 in the preservation/restoration of endothelial function in an angiotensin II (Ang II) cellular model of hypertension. Methods: 1,25-dihydroxy vitamin D3-stimulated nitric oxide (NO) and peroxynitrite (ONOO-) concentrations were measured in situ with nanosensors (200-300 mm diameter with a detection limit of 1 nM) in human umbilical vein endothelial cells of African American (AA) and Caucasian American (CA) donors exposed to Ang II...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29411910/paratesticular-seminoma-echographic-features-and-histological-diagnosis-with-review-of-the-literature
#10
Andrea Palicelli, Pierluigi Neri, Giansilvio Marchioro, Paolo De Angelis, Gianmarco Bondonno, Antonio Ramponi
Primary extratesticular seminomas exceptionally occur in the epididymis or in the paratesticular region/spermatic cord. Some old papers included poor histological description or insufficient photographic documentation, reducing the number of faithful cases: an up-to-date systematic review is lacking. We report the 4th primary seminoma of the paratesticular region/spermatic cord in a 35-year-old man, including the first echographic description. We provide review of the literature and etiopathogenetic discussion...
February 7, 2018: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/29411727/effect-of-titanium-prepared-platelet-rich-fibrin-treatment-on-the-angiogenic-biomarkers-in-gingival-crevicular-fluid-in-infrabony-defects-of-patients-with-chronic-periodontitis-a-randomized-controlled-clinical-trial
#11
H G Pirebas, M K Hendek, U Kisa, M Yalim, E O Erdemir
AIM: The aim of this double-blinded, randomized, controlled clinical study was to investigate the effect of titanium-prepared platelet-rich fibrin (T-PRF) treatment on the angiogenic biomarkers in gingival crevicular fluid (GCF) in infrabony defects of patients with chronic periodontitis. MATERIALS AND METHODS: Twenty five systemically healthy participants who complied with inclusion criteria with periodontal infrabony defects were recruited. In each patient, the infrabony defect of one side of arch was designated as control group (allograft), whereas the infrabony defect on the contralateral side of same arch was designated as test group (allograft + T-PRF)...
January 2018: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29393347/renal-transplantation-increases-angiotensin-ii-receptor-mediated-vascular-contractility-associated-with-changes-of-epigenetic-mechanisms
#12
Yakun Zhao, Qingguo Zhu, Shiping Sun, Yu Qiu, Jingquan Li, Wei Liu, Gangjun Yuan, Hua Ma
Hypertension is one of the most common complications following renal transplantation, and it increases the risk of graft loss and other cardiovascular diseases. Previous studies have revealed that the use of angiotensin II (Ang II) blockers for preventing and treating hypertension is closely associated with higher survival following renal transplantation. However, the cellular and molecular mechanisms by which the vascular contractility of the recipient is altered in response to Ang II following renal transplantation have not been fully elucidated...
January 29, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29391267/association-between-grade-of-acute-on-chronic-liver-failure-and-response-to-terlipressin-and-albumin-in-patients-with-hepatorenal-syndrome
#13
Salvatore Piano, Hartmut H Schmidt, Xavier Ariza, Alex Amoros, Antonietta Romano, Anna Hüsing-Kabar, Elsa Solà, Alexander Gerbes, Mauro Bernardi, Carlo Alessandria, Bernhard Scheiner, Marta Tonon, Miriam Maschmeier, Cristina Solè, Jonel Trebicka, Thierry Gustot, Frederik Nevens, Vicente Arroyo, Pere Gines, Paolo Angeli
BACKGROUND & AIMS: Type-1 hepatorenal syndrome (HRS) is the most high-risk type of renal failure in patients with cirrhosis. Terlipressin and albumin are effective treatments for type-1 HRS. However, the effects of acute on chronic liver failure (ACLF) grade on response to treatment are not clear. We aimed to identify factors associated with response to treatment with terlipressin and albumin in patients with type 1 HRS (reduction in serum level of creatinine to below 1.5 mg/dl at the end of treatment) and factors associated with death within 90 days of HRS diagnosis (90-day mortality)...
January 29, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29382905/biological-corneal-inlay-for-presbyopia-derived-from-small-incision-lenticule-extraction-smile
#14
Yu-Chi Liu, Ericia Pei Wen Teo, Heng Pei Ang, Xin Yi Seah, Nyein Chan Lwin, Gary Hin Fai Yam, Jodhbir S Mehta
Corneal inlays are a relatively new treatment option for presbyopia. Using biological inlays, derived from lenticules extracted from small incision lenticule extraction, may offer advantages over commercialized synthetic inlays in the aspect of biocompatibility. We conducted a non-human primate study to evaluate the safety, predictability, efficacy and tissue response after autogeneic, decellularized xenogeneic and xenogeneic lenticule implantation. The lenticule implantation effectively resulted in central corneal steepening (simulated keratometric values increased by 1...
January 30, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29379943/efficacy-of-oral-mixed-tocotrienols-in-diabetic-peripheral-neuropathy-a-randomized-clinical-trial
#15
Chee Peng Hor, Wai Yee Fung, Hock Aun Ang, Sheau Chin Lim, Li Ying Kam, Su-Way Sim, Luen Hui Lim, Wai Yee Choon, Jia Woei Wong, Alan Swee Hock Ch'ng, Kelvin Khai Meng Beh, Hong Chin Wee, Loke Meng Ong, Nurzalina Abdul Karim Khan, Syed Azhar Syed Sulaiman, Ibrahim Lutfi Shuaib, Adlina Bakar, Yusnita Yusof, Yusmawati Mohd Yusof, Fatimah Abu Bakar, Wei Shuong Tang, Hoon Lang Teh, Normala Abdul Wahid, Suriani Saaidin, Najihah Idris, Chee Kin Yoon, Hoon Ngoh Ong, Jayasumithra T Ganapathy, Ching Ee Loo, Michelle M Samy, Hadzlinda Zainal, Shalini C Sree Dharan, Bee Yen Ooi, Pei Yeing Teoh, Yi Loon Tye, Chin Aun Yeoh, Dy Win Low, Irene Looi, Kah Hay Yuen
Importance: Management of painful diabetic peripheral neuropathy remains challenging. Most therapies provide symptomatic relief with varying degrees of efficacy. Tocotrienols have modulatory effects on the neuropathy pathway and may reduce neuropathic symptoms with their antioxidative and anti-inflammatory activities. Objective: To evaluate the efficacy of oral mixed tocotrienols for patients with diabetic peripheral neuropathy. Design, Setting, and Participants: The Vitamin E in Neuroprotection Study (VENUS) was a parallel, double-blind, placebo-controlled trial that recruited participants from January 30, 2011, to December 7, 2014, with 12 months of follow-up...
January 29, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29369152/paracanthal-one-snip-decompression-in-a-cadaver-model-of-retrobulbar-hemorrhage
#16
Alexander D Blandford, Jason M Young, Sruthi Arepalli, Ang Li, Catherine J Hwang, Julian D Perry
PURPOSE: The authors assess the effectiveness of a modified paracanthal or "one-snip" procedure compared with the traditional lateral canthotomy and inferior cantholysis in the reduction of intraocular pressure (IOP) and proptosis in a human cadaveric model of retrobulbar hemorrhage. METHODS: This study comprised a comparative interventional study in a cadaveric model of retrobulbar hemorrhage. Six orbits of 3 fresh cadavers were included in the study. Baseline measurements of IOP and proptosis were recorded for all 6 orbits before and after simulation of retrobulbar hemorrhage as previously described...
January 23, 2018: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29366881/metallic-gold-and-bioactive-quinacrine-hybrid-nanoparticles-inhibit-oral-cancer-stem-cell-and-angiogenesis-by-deregulating-inflammatory-cytokines-in-p53-dependent-manner
#17
Shakti Ranjan Satapathy, Anmada Nayak, Sumit Siddharth, Sarita Das, Deepika Nayak, Chanakya Nath Kundu
Complete eradication of aggressive oral cancer remains a challenge due to the presence of CSCs. They resist to conventional chemotherapeutic agents due to their self-renewal, drug efflux, and efficient DNA repair capacity. Here, we formulated a hybrid-nanoparticle (QAuNP) using quinacrine and gold and characterized; investigated its anti-angiogenic and anti-metastatic effect on OSCC-CSCs. QAuNP significantly inhibited cellular proliferation, caused apoptosis in vitro, disrupted angiogenesis in vivo and tumor regression in xenograft mice model...
January 20, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/29363361/influence-of-the-oral-status-on-cardiovascular-diseases-in-an-older-italian-population
#18
Francesca De Angelis, Stefania Basili, Fratto Giovanni, Pompiliu Dan Trifan, Stefano Di Carlo, Licia Manzon
Oral diseases have been adversely associated with cardiovascular diseases (CVD), which are also the most frequent cause of death in older population. The aim of this study was to investigate the association among oral status indexes and CVD in patients aged more than 65 years attending in the Oral department of a public hospital Policlinico Umberto 1 of Rome. The study population consisted of 533 patients. Dental status was detected measuring the Decayed, Missing, and Filled Teeth (DMFT) and Community Periodontal Index (CPI) indexes...
January 2018: International Journal of Immunopathology and Pharmacology
https://www.readbyqxmd.com/read/29358118/polygenic-risk-for-alzheimer-s-disease-influences-precuneal-volume-in-two-independent-general-populations
#19
Jin Li, Xiaolong Zhang, Ang Li, Shu Liu, Wen Qin, Chunshui Yu, Yong Liu, Bing Liu, Tianzi Jiang
Alzheimer's disease (AD) is heritable with complex genetic underpinnings. Based on previous results from large-scale genome-wide association studies, recent studies found an association between the polygenic risk score (PGRS) of AD and the structure of some preselected brain regions, but the effects of AD PGRS on all voxels of the brain have not been fully investigated. In the present study, we examined the voxel-wise effect of AD PGRS on the entire brain and the influence of AD PGRS on cognitive function in 2 independent healthy young cohorts...
December 30, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/29356920/3d-accuracy-of-implant-positions-in-template-guided-implant-placement-as-a-function-of-the-remaining-teeth-and-the-surgical-procedure-a-retrospective-study
#20
Sigmar Schnutenhaus, Cornelia Edelmann, Heike Rudolph, Jens Dreyhaupt, Ralph G Luthardt
OBJECTIVE: The aim of this study was to investigate differences between the virtually planned and clinically achieved implant positions in completely template-guided implantations as a function of the type of edentulous space, the residual natural dentition, and the surgical implementation. MATERIALS AND METHODS: Fifty-six patient cases with a total of 122 implants were evaluated retrospectively. The implantations were completely template-based. The data of the planned implant positions were overlaid with the actual clinical implant positions, followed by measurements of the 3D deviations in terms of coronal (xc) and apical distance, height (xh), and angulation (ang) and statistical analysis...
January 22, 2018: Clinical Oral Investigations
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