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https://www.readbyqxmd.com/read/29221165/angiogenesis-in-adenosquamous-cancer-of-pancreas
#1
Nicola Silvestris, Katia Danza, Vito Longo, Oronzo Brunetti, Livia Fucci, Antonella Argentiero, Angela Calabrese, Ivana Cataldo, Roberto Tamma, Domenico Ribatti, Stefania Tommasi
Adenosquamous carcinoma of the pancreas (ASCP) is an uncommon variant of exocrine pancreatic malignancies, characterized by a histological admixture of adenomatous and squamous cell elements. This cancer is characterized by a poorly differentiated histology and a poorer clinical outcome compared to pancreatic ductal adenocarcinoma (PDAC). Unlike PDAC, that is characterized by a low microvascular density (MVD) and collapsed vasculature, no data are available about angiogenesis in ASPC. Immunohistochemical evaluation of MVD and trypatse-positive mast cells (MCs) were performed on a single case of ASCP compared to PDAC...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29212395/prenatal-prediction-of-small-for-gestational-age-neonates-using-mr-imaging-comparison-with-conventional-2d-ultrasound
#2
Andrew Carlin, Caroline Kadji, Riccardo De Angelis, Mieke M Cannie, Jacques C Jani
PURPOSE: To evaluate the performance of estimating fetal weight (EFW) using magnetic resonance (MR) imaging as compared with two-dimensional (2D) ultrasound (US) in the prediction of small-for-gestational age neonates (SGA). MATERIALS & METHODS: Written informed consent was obtained for this Ethical Committee approved study. Between March 2011 and May 2016, women with singleton pregnancies underwent US-EFW and MR-EFW within 48 h before delivery. US-EFW was based on Hadlock et al...
December 6, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29167164/nrf2-prevents-hypertension-increased-adma-microvascular-oxidative-stress-and-dysfunction-in-mice-with-two-weeks-of-angiotensin-ii-infusion
#3
Cheng Wang, Zaiming Luo, Gabriella Carter, Anton Wellstein, Pedro A Jose, James Tomlinson, James Leiper, William J Welch, Christopher S Wilcox, Dan Wang
Nuclear factor erythyroid factor 2 (Nrf2) transcribes genes in cultured endothelial cells that reduce reactive oxygen species (ROS) and generate nitric oxide (NO) or metabolize asymmetric dimethylarginine (ADMA) that inhibits NO synthase (NOS). Therefore, we undertook a functional study to test the hypothesis that activation of Nrf2 by tert-butylhydroquinone (tBHQ) preserves microvascular endothelial function during oxidative stress. Wild-type CB57Bl/6 (wt), Nrf2 wt (+/+), or knockout (-/-) mice received vehicle (Veh) or tBHQ (0...
November 22, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29166708/-effects-of-astragalus-polysaccharide-on-cardiac-dysfunction-in-rabbits-with-severe-scald-injury
#4
L Zhong, J H Zhan, J H Luo, X Cheng
Objective: To investigate the effects of astragalus polysaccharide (AP) on cardiac dysfunction in rabbits with severe scald injury. Methods: Sixty-four New Zealand white rabbits were divided into pure scald group and AP group according to the random number table, with 32 rabbits in each group. Rabbits in the two groups were all inflicted with 30% total body surface area full-thickness scald on the back. Immediately after injury, rabbits in two groups were intraperitoneally injected with lactated Ringer's solution once for antishock...
November 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/29151687/medium-term-anatomical-results-of-laser-peripheral-iridoplasty-an-anterior-segment-optical-coherence-tomography-study
#5
Joobin Hooshmand, James Cy Leong, Jeremy O'Connor, Ghee S Ang, Anthony P Wells
Aim: To evaluate by anterior segment optical coherence tomography (AS-OCT) the medium-term (mean duration 3.2 years) anatomical changes in the anterior chamber angle (ACA) after laser peripheral iridoplasty. Materials and methods: This is a longitudinal, retrospective case series of 31 eyes of 31 patients with primary angle-closure suspicion, primary angle closure (PAC), or primary angle-closure glaucoma (PACG) who underwent laser peripheral iridoplasty. All patients had persistent iridotrabecular contact (ITC) despite the presence of a patent peripheral iridotomy (PI)...
September 2017: Journal of Current Glaucoma Practice
https://www.readbyqxmd.com/read/29151032/elevated-baseline-serum-fibrinogen-effect-on-2-year-major-adverse-cardiovascular-events-following-percutaneous-coronary-intervention
#6
Lawrence Ang, Omid Behnamfar, Samhita Palakodeti, Felice Lin, Ali Pourdjabbar, Mitul P Patel, Ryan R Reeves, Ehtisham Mahmud
BACKGROUND: Elevated fibrinogen is associated with short-term major adverse cardiovascular events (MACE) after percutaneous coronary intervention, but the relation with late MACE is unknown. METHODS AND RESULTS: Baseline demographics and 2-year MACE were recorded among subjects undergoing nonemergent percutaneous coronary intervention. A total of 332 subjects (66.6±19.5 years, 69.9% male, 25.3% acute coronary syndrome) were enrolled. Two-year MACE (periprocedural myocardial infarction 9...
November 18, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29149676/high-salt-diet-decreases-reproductive-performance-in-rams-and-down-regulates-gene-expression-of-some-components-of-the-renin-angiotensin-system-in-the-testis
#7
Yi Fang, Rongzhen Zhong, Xuezhao Sun, Daowei Zhou
Although salt-tolerant plants can be used to combat dryland salinity, these plants contain high concentrations of salt (NaCl), which may have deleterious effects if fed to livestock. Twenty-four Merino rams (9 mo of age) with similar body weight were equally allocated to two groups and fed a normal- or high-salt diet (0.5 and 12% NaCl, respectively) for 3 mo. Rams fed the high-salt diet had lower live weight gains, higher water intake, smaller testes (466 ± 48.4 vs 604 ± 51.1 g) and reductions (P <0...
November 10, 2017: Theriogenology
https://www.readbyqxmd.com/read/29130489/angiotensin-1-7-modulates-electrophysiological-characteristics-and-calcium-homeostasis-in-pulmonary-veins-cardiomyocytes-via-mas-pi3k-enos-signaling-pathway
#8
Yen-Yu Lu, Wen-Shiann Wu, Yung-Kuo Lin, Chen-Chuan Cheng, Yao-Chang Chen, Shih-Ann Chen, Yi-Jen Chen
BACKGROUND: Atrial fibrillation (AF) is the most common sustained arrhythmia, and pulmonary veins (PVs) play a critical role in triggering AF. Angiotensin (Ang)-(1-7) regulates calcium (Ca(2+) ) homeostasis and also plays a critical role in cardiovascular pathophysiology. However, the role of Ang-(1-7) in PV arrhythmogenesis remains unclear. MATERIALS AND METHODS: Conventional microelectrodes, whole-cell patch-clamp, and the Fluo-3 fluorimetric ratio technique were used to record ionic currents and intracellular Ca(2+) in isolated rabbit PV preparations, and in single isolated PV cardiomyocytes, before and after administration of Ang-(1-7)...
November 12, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29128399/nitric-oxide-production-by-glomerular-podocytes
#9
Oleg Palygin, Daria V Ilatovskaya, Vladislav Levchenko, Bradley T Endres, Aron M Geurts, Alexander Staruschenko
Nitric Oxide (NO), a potent vasodilator and vital signaling molecule, has been shown to contribute to the regulation of glomerular ultrafiltration. However, whether changes in NO occur in podocytes during the pathogenesis of salt-sensitive hypertension has not yet been thoroughly examined. We showed here that podocytes produce NO, and further hypothesized that hypertensive animals would exhibit reduced NO production in these cells in response to various paracrine factors, which might contribute to the damage of glomeruli filtration barrier and development of proteinuria...
November 8, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/29121075/functional-evaluation-of-therapeutic-response-of-hcc827-lung-cancer-to-bevacizumab-and-erlotinib-targeted-therapy-using-dynamic-contrast-enhanced-and-diffusion-weighted-mri
#10
Yi-Fang Chen, Ang Yuan, Kuan-Hung Cho, Yi-Chien Lu, Mark Yen-Ping Kuo, Jyh-Horng Chen, Yeun-Chung Chang
This study aimed to investigate the therapeutic responses of lung cancer mice models with adenocarcinoma HCC827 (gefitinib sensitive) and HCC827R (gefitinib resistant) to the epidermal growth factor receptor-tyrosine kinase inhibitor erlotinib alone and in combination with the anti-angiogenesis agent bevacizumab using dynamic contrast enhanced (DCE) and diffusion-weighted MRI. In the HCC827 model, temporal changes in DCE-MRI derived parameters (Ktrans, kep, and iAUC90) and apparent diffusion coefficient (ADC) were significantly correlated with tumor size...
2017: PloS One
https://www.readbyqxmd.com/read/29113826/ghrelin-suppresses-cardiac-fibrosis-of-post-myocardial-infarction-heart-failure-rats-by-adjusting-the-activin-a-follistatin-imbalance
#11
Chunyan Yang, Jinsha Liu, Kai Liu, Beibei Du, Kaiyao Shi, Mei Ding, Bing Li, Ping Yang
Ghrelin, a growth hormone-releasing peptide, potentially improves cardiac function, but the mechanisms remain unclear. In the study, the rat heart failure (HF) model was established by ligating the left anterior descending coronary artery (LAD) and treated with ghrelin (100μg/kg, subcutaneous injection, bid); neonatal rat cardiomyocytes were cultured and stimulated with Ang II (0.1μM) and ghrelin(0.1μM) to explore the underlying mechanism of ghrelin in myocardial remodeling. Hemodynamic changes and serum brain natriuretic peptide (BNP) concentrations were measured to assess cardiac function...
November 4, 2017: Peptides
https://www.readbyqxmd.com/read/29095811/clinical-whole-exome-sequencing-for-the-diagnosis-of-rare-disorders-with-congenital-anomalies-and-or-intellectual-disability-substantial-interest-of-prospective-annual-reanalysis
#12
Sophie Nambot, Julien Thevenon, Paul Kuentz, Yannis Duffourd, Emilie Tisserant, Ange-Line Bruel, Anne-Laure Mosca-Boidron, Alice Masurel-Paulet, Daphné Lehalle, Nolwenn Jean-Marçais, Mathilde Lefebvre, Pierre Vabres, Salima El Chehadeh-Djebbar, Christophe Philippe, Frederic Tran Mau-Them, Judith St-Onge, Thibaud Jouan, Martin Chevarin, Charlotte Poé, Virginie Carmignac, Antonio Vitobello, Patrick Callier, Jean-Baptiste Rivière, Laurence Faivre, Christel Thauvin-Robinet
PurposeCongenital anomalies and intellectual disability (CA/ID) are a major diagnostic challenge in medical genetics-50% of patients still have no molecular diagnosis after a long and stressful diagnostic "odyssey." Solo clinical whole-exome sequencing (WES) was applied in our genetics center to improve diagnosis in patients with CA/ID.MethodsThis retrospective study examined 416 consecutive tests performed over 3 years to demonstrate the effectiveness of periodically reanalyzing WES data. The raw data from each nonpositive test was reanalyzed at 12 months with the most recent pipeline and in the light of new data in the literature...
November 2, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/29093566/hypertension-induces-additional-cardiometabolic-impairments-and-attenuates-aerobic-exercise-training-adaptations-in-fructose-fed-ovariectomized-rats
#13
Janaina de O Brito-Monzani, Iris Callado Sanches, Nathalia Bernardes, Kátia Ponciano, Ivana C Moraes-Silva, Maria-Cláudia Irigoyen, Susana Llesuy, Kátia De Angelis
We tested whether hypertension favors the development of additional cardiometabolic changes in fructose-fed ovariectomized rats and how it affects aerobic exercise training (ET) effects. All rats received fructose in drinking water (10%) beginning at weaning, were ovariectomized at 10 weeks of age and divided into the normotensive sedentary (NFOS) and trained (NFOT) and hypertensive sedentary (HFOS) and trained (HFOT) groups. ET was performed on a treadmill. Arterial pressure (AP) was directly recorded; heart rate and AP variabilities were analyzed...
November 2, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29072703/bcl6-attenuates-renal-inflammation-via-negative-regulation-of-nlrp3-transcription
#14
Dan Chen, Xiao-Qing Xiong, Ying-Hao Zang, Ying Tong, Bing Zhou, Qi Chen, Yue-Hua Li, Xing-Ya Gao, Yu-Ming Kang, Guo-Qing Zhu
Renal inflammation contributes to the pathogeneses of hypertension. This study was designed to determine whether B-cell lymphoma 6 (BCL6) attenuates renal NLRP3 inflammasome activation and inflammation and its underlying mechanism. Male spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY) were used in the present study. Angiotensin (Ang) II or lipopolysaccharides (LPS) was used to induce inflammation in HK-2 cells, a human renal tubular epithelial (RTE) cell line. NLRP3 inflammasome was activated and BCL6 was downregulated in the kidneys of SHR...
October 26, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29072547/serum-concentrations-of-ang-2-and-flt-1-may-be-predictive-of-pregnancy-outcome-in-women-with-pregnancies-of-uncertain-viability-a-phase-i-exploratory-prognostic-factor-study
#15
Alison Richardson, Shilpa Deb, Bruce Campbell, Nick Raine-Fenning
The aim of this study was to determine whether serum concentrations of Ang-1, Ang-2, Flt-1, IL-15 and/or TRAIL can be used to predict outcome in women with pregnancies of uncertain viability (PUVs). Women presenting to the Early Pregnancy Unit at the Queen's Medical Centre in Nottingham between 17.06.14 and 01.09.15 were prospectively recruited. Serum concentrations of Ang-1, Ang-2, Flt-1, IL-15 and TRAIL were measured in women with PUVs. Women were followed-up according to departmental protocols until viability was determined...
October 26, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29071954/-protective-effect-of-acupuncture-serum-derived-from-acute-convulsion-rats-on-cultured-hip-pocampal-neurons-with-seizure-like-discharges-by-regulating-expression-of-endoplasmic-reticulum-stress-inducible-molecular-chaperones
#16
Hui Zhang, Fan Yang, Xu Wu, De-Kai Shen, Hao Chen, Sheng-Bing Wu, Wen-Ping Ang, Xiao-Ge Song, Ming-Yue Xie
OBJECTIVE: To observe the effect of acupuncture serum on the number of apoptosis of the cultured hippocampal neurons with seizure-like discharges and the expression levels of endoplasmic reticulum stress-inducible molecular chaperones glucose-regulated protein 78 (GRP 78), C/EBP homologous protein (CHOP) and cysteine protease protein-12(Caspase-12), so as to reveal its protective mechanism on seizure-induced injury of hippocampal neurons. METHODS: A regular primary culture of neurons derived from the hippocampus of the newly-born SD rats was conducted for 10 days, then these cultured neurons that displayed seizure-like discharges in Mg(2+)-free medium were divided into normal extracellular fluid (medium) group (normal), Mg(2+)-free medium group, acupuncture serum group and non-acupuncture serum group (n=30)...
April 25, 2017: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/29070570/hypoxia-reoxygenation-enhances-murine-afferent-arteriolar-vasoconstriction-by-angiotensin-ii
#17
Tamara Margit Pahlitzsch, Zhi Zhao Liu, Amira Al-Masri, Diana Braun, Stefanie Dietze, Pontus B Persson, Wolf-Hagen Schunck, Maximilian Blum, Eckehardt Kupsch, Marion Ludwig, Andreas Patzak
We tested the hypothesis that hypoxia/reoxygenation (H/R) augments vasoreactivity to angiotensin II (Ang II). In particular, we compared an in situ live kidney slice model with isolated afferent arterioles (C57Bl6 mice) to assess the impact of tubules on microvessel response. H&E staining was used to estimate slice viability. Arterioles in the slices were located by DIC microscopy, and responses to vasoactive substances were assessed. Cytosolic calcium transients and NADPH oxidase mRNA expression were studied in isolated afferent arterioles...
October 25, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29058665/real-time-modelling-of-a-pandemic-influenza-outbreak
#18
Paul J Birrell, Richard G Pebody, André Charlett, Xu-Sheng Zhang, Daniela De Angelis
BACKGROUND: Real-time modelling is an essential component of the public health response to an outbreak of pandemic influenza in the UK. A model for epidemic reconstruction based on realistic epidemic surveillance data has been developed, but this model needs enhancing to provide spatially disaggregated epidemic estimates while ensuring that real-time implementation is feasible. OBJECTIVES: To advance state-of-the-art real-time pandemic modelling by (1) developing an existing epidemic model to capture spatial variation in transmission, (2) devising efficient computational algorithms for the provision of timely statistical analysis and (3) incorporating the above into freely available software...
October 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29045452/prospective-multicenter-french-study-evaluating-the-clinical-impact-of-the-breast-cancer-intrinsic-subtype-prosigna%C3%A2-test-in-the-management-of-early-stage-breast-cancers
#19
MULTICENTER STUDY
Delphine Hequet, Céline Callens, David Gentien, Benoit Albaud, Marie-Ange Mouret-Reynier, Coraline Dubot, Paul Cottu, Cyrille Huchon, Sonia Zilberman, Helene Berseneff, Cyril Foa, Rémy Salmon, Aurélie Roulot, Florence Lerebours, Anne Salomon, Nadeem Ghali, Pascale Morel, Qianyi Li, Anne Cayre, Jean-Marc Guinebretière, John Hornberger, Frédérique Penault-Llorca, Roman Rouzier
PURPOSE: The Prosigna® breast cancer prognostic gene signature assay identifies a gene-expression profile that permits the classification of tumors into subtypes and gives a score for the risk of recurrence (ROR) at 10 years. The primary objective of this multicenter study was to evaluate the impact of Prosigna's assay information on physicians' adjuvant treatment decisions in patients with early-stage breast cancer. Secondary objectives were to assess confidence of practitioners in their therapeutic recommendations before and after the added information provided by the Prosigna assay; and to evaluate the emotional state of patients before and after the Prosigna test results...
2017: PloS One
https://www.readbyqxmd.com/read/29040151/sex-differences-in-vascular-reactivity-to-angiotensin-ii-during-the-evolution-of-myocardial-infarction
#20
Flores-Monroy Jazmín, Ramirez-Hernández Diana, Samano-Hernández Citali, Lezama-Martínez Diego, Sampieri-Cabrera Raul, Martínez-Aguilar Luisa
The influence of sex on the vascular response during the progression of myocardial infarction (MI) has not been extensively studied. In this work, we analyzed the differences of the vasoconstriction-induced by angiotensin II (Ang II) in the absence and presence of valsartan (200 nM) on the aortic rings of male and female Wistar rats at 2, 4, 24, and 48 h and 1, 2, 3, and 4 weeks after induction of MI. In the aortic rings of males an increase was observed in the contractile response that lasts up to 4 weeks; on females, this effect is diminished since 48 h until reaching sham group values at 2 weeks of coronary occlusion...
September 29, 2017: Journal of Cardiovascular Pharmacology
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