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Ang 2 AND NO

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https://www.readbyqxmd.com/read/27932265/ottawa-panel-evidence-based-clinical-practice-guidelines-for-structured-physical-activity-in-the-management-of-juvenile-idiopathic-arthritis
#1
REVIEW
Sabrina Cavallo, Lucie Brosseau, Karine Toupin-April, George A Wells, Christine A M Smith, Arlanna G Pugh, Jennifer Stinson, Roanne Thomas, Sara Ahmed, Ciarán M Duffy, Prinon Rahman, Inmaculada C Àlvarez-Gallardo, Laurianne Loew, Gino De Angelis, Debbie Ehrmann Feldman, Annette Majnemer, Isabelle J Gagnon, Désirée Maltais, Marie-Ève Mathieu, Glen P Kenny, Susan Tupper, Kristi Whitney-Mahoney, Sarah Bigford
OBJECTIVE: To create guidelines focused on the use of structured physical activity (PA) in the management of juvenile idiopathic arthritis (JIA). DATA SOURCES: A systematic literature search was conducted using the electronic databases Cochrane Central Register of Controlled Trials, Medline (Ovid), EMBASE (Ovid), and Physiotherapy Evidence Database (PEDro) for all studies related to PA programs for JIA from January 1966 until December 2014, and was updated in May 2015...
December 5, 2016: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/27909412/modeling-disease-progression-angiotensin-ii-indirectly-inhibits-nitric-oxide-production-via-adma-accumulation-in-spontaneously-hypertensive-rats
#2
Haidong Wang, Hao Jiang, Haochen Liu, Xue Zhang, Guimei Ran, Hua He, Xiaoquan Liu
Nitric oxide (NO) production impairment is involved in the onset and development of hypertension. Although NO production impairment in spontaneously hypertensive rat (SHR) has been reported in a variety of researches, the time course of this progressive procedure, as well as its relationship with asymmetric dimethylarginine (ADMA) and angiotensin II (Ang II), has not been quantified. The aim of this research is to establish a mechanism-based disease progression model to assess Ang II and ADMA's inhibition of NO production in SHR's disease progression with/without ramipril's intervention...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27909084/sustained-benefits-of-exercise-based-motivational-interviewing-but-only-among-nonusers-of-opioids-in-patients-with-fibromyalgia
#3
Sunghye Kim, James E Slaven, Dennis C Ang
OBJECTIVE: Given the known side effects of opioids and their potential effects on cognition, we sought to evaluate the benefits of motivational interviewing (MI) to promote physical activity on 2 subsets of participants with fibromyalgia (FM): nonusers and users of opioids. METHODS: This was a secondary data analysis of a 36-week randomized controlled trial to assess the efficacy of MI to promote physical activity among participants with FM. Participants were randomized to 1 of 2 treatment arms: 6 phone-based MI sessions (n = 107) or 6 sessions of FM self-management instructions [attention control (AC), n = 109]...
December 1, 2016: Journal of Rheumatology
https://www.readbyqxmd.com/read/27905921/systematic-review-of-the-role-of-angiopoietin-1-and-angiopoietin-2-in-plasmodium-species-infections-biomarkers-or-therapeutic-targets
#4
Gerdie M de Jong, Jasper J Slager, Annelies Verbon, Jaap J van Hellemond, Perry J J van Genderen
BACKGROUND: Levels of both angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2) correlate with malaria disease severity and are proposed as biomarkers and possible therapeutic targets. To establish their role in malaria, a systematic review was performed of the literature on Ang-1 and Ang-2 with regard to their potential as biomarkers in malaria and discuss their possible place in adjuvant treatment regimens. METHODS: Ten electronic databases were systematically searched to identify studies investigating Ang-1 and Ang-2 in human and murine malaria in both clinical and experimental settings...
December 1, 2016: Malaria Journal
https://www.readbyqxmd.com/read/27899891/cardiac-stat3-deficiency-impairs-contractility-and-metabolic-homeostasis-in-hypertension
#5
Raffaele Altara, Romain Harmancey, Sean P Didion, George W Booz, Fouad A Zouein
Signal transducer and activator of transcription 3 (STAT3) protects the heart from acute ischemic stress. However, the importance of STAT3 to the heart in chronic stress, such as hypertension, is not known. To study this, we used cardiomyocyte-targeted STAT3 knockout (KO) mice and Angiotensin II (ANG II) infusion by osmotic minipumps. After 4 weeks, ANG II induced similar cardiac hypertrophy in wild type (WT) and cardiac Cre-expressing control (CTRL) mice with no impairment of cardiac function. In contrast, STAT3 KO mice exhibited reduced contractile function but similar hypertrophy to CTRL mice...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27896943/ang-1-7-protects-cardiomyocytes-against-hg-induced-injuries-through-inhibiting-ros-activated-leptin-p38-mapk-erk1-2-pathways-but-not-leptin-jnk-pathway-in-vitro
#6
Yiyan Lei, Qing Xu, Bo Zeng, Wei Zhang, Yulan Zhen, Yuansheng Zhai, Fei Cheng, Weiyi Mei, Dongdan Zheng, Jianqiang Feng, Jun Lan, Jingfu Chen
AIMS: Angiotensin-(1-7) [Ang-(1-7)], recognized as a new bioactive peptide in renin-angiotensin system (RAS), shows biological and pharmacological properties in diabetic cardiovascular diseases. Leptin induced-p38 MAPK pathway has been reported to contribute to the high glucose (HG)-induced injury. In this study, we demonstrated the mechanism that how Ang-(1-7) can protect from HG-stimulated injuries in H9c2 cells. METHODS: H9c2 cells were treated with 35 mM glucose (HG) for 24 h to establish a model of HG-induced damage...
November 29, 2016: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/27889753/renal-denervation-attenuates-multi-organ-fibrosis-and-improves-vascular-remodeling-in-rats-with-transverse-aortic-constriction-induced-cardiomyopathy
#7
Kai Wang, Dasheng Lu, Bin Zhang, Shengchan Wang, Qian Liu, Qi Zhang, Jie Geng, Qijun Shan
BACKGROUND/AIMS: To investigate the effects of renal denervation (RDN) on multi-organ fibrosis and vascular remodeling in cardiomyopathy. METHODS: Thirty-six male Sprague-Dawley rats underwent transverse aortic constriction (TAC). Five weeks later, 28 surviving TAC rats were randomly assigned to three groups: (1) RDN, (2) Sham, (3) Carvedilol. Six male Sham TAC rats served as the Control. Ten weeks after TAC, samples were collected. RESULTS: TAC rats showed an increased diastolic interventricular septal thickness at week 5...
November 25, 2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27888281/the-actions-of-relaxin-family-peptides-on-signal-transduction-pathways-activated-by-the-relaxin-family-peptide-receptor-rxfp4
#8
Sheng Y Ang, Dana S Hutchinson, Bronwyn A Evans, Mohammed A Hossain, Nitin Patil, Ross A D Bathgate, Martina Kocan, Roger J Summers
The relaxin family peptide receptor 4 (RXFP4) is a G protein-coupled receptor (GPCR) expressed in the colorectum with emerging roles in metabolism and appetite regulation. It is activated by its cognate ligand insulin-like peptide 5 (INSL5) that is expressed in enteroendocrine L cells in the gut. Whether other evolutionarily related peptides such as relaxin-2, relaxin-3, or INSL3 activate RXFP4 signal transduction mechanisms with a pattern similar to or distinct from INSL5 is still unclear. In this study, we compare the signaling pathways activated by various relaxin family peptides to INSL5...
November 26, 2016: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/27878396/new-dinitrosyl-iron-complexes-bound-with-physiologically-active-dipeptide-carnosine
#9
Konstantin B Shumaev, Olga V Kosmachevskaya, Elvira I Nasybullina, Sergey V Gromov, Alexander A Novikov, Alexey F Topunov
Dinitrosyl iron complexes (DNICs) are physiological NO derivatives and account for many NO functions in biology. Polyfunctional dipeptide carnosine (beta-alanyl-L-histidine) is considered to be a very promising pharmacological agent. It was shown that in the system containing carnosine, iron ions and Angeli's salt, a new type of DNICs bound with carnosine as ligand {(carnosine)2-Fe-(NO)2}, was formed. We studied how the carbonyl compound methylglyoxal influenced this process. Carnosine-bound DNICs appear to be one of the cell's adaptation mechanisms when the amount of reactive carbonyl compounds increases at hyperglycemia...
November 22, 2016: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/27872953/a-phase-i-study-of-afatinib-combined-with-paclitaxel-and-bevacizumab-in-patients-with-advanced-solid-tumors
#10
James Spicer, Sheeba Irshad, Joo Ern Ang, Deborah Enting, Rebecca Kristeleit, Martina Uttenreuther-Fischer, Karine Pemberton, Katy Pelling, David Schnell, Johann de Bono
PURPOSE: The combination of afatinib, an irreversible ErbB family blocker, with paclitaxel and bevacizumab was assessed in patients with advanced solid tumors. METHODS: This phase I study used a 3 + 3 design to determine the maximum tolerated dose (MTD) of afatinib combined with paclitaxel and bevacizumab. Safety, pharmacokinetics, and anti-tumor activity were also assessed. The starting dose was oral afatinib 40 mg once daily plus intravenous paclitaxel (fixed dose 80 mg/m(2), Days 1, 8, and 15 of a 4-week cycle) and intravenous bevacizumab 5 mg/kg every 2 weeks...
November 21, 2016: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/27867691/efficacy-of-small-volume-simethicone-given-at-least-30-min-before-gastroscopy
#11
Mingjun Song, Andrew Boon Eu Kwek, Ngai Moh Law, Jeannie Peng Lan Ong, Jessica Yi-Lyn Tan, Prem Harichander Thurairajah, Daphne Shih Wen Ang, Tiing Leong Ang
AIM: To evaluate the efficacy of 5 mL simethicone solution in decreasing gastric foam if given at least 30 min before gastroscopy. METHODS: This was a randomized, placebo controlled, endoscopist blinded study performed at Changi General Hospital. Patients were at least 21 years old, had no prior surgical resection of the upper gastrointestinal tract, and scheduled for elective diagnostic gastroscopies. The primary outcome was the total mucosal visibility score (TMVS) which was evaluated using McNally score...
November 6, 2016: World Journal of Gastrointestinal Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27861620/prazosin-can-prevent-glucocorticoid-mediated-capillary-rarefaction
#12
Erin R Mandel, Emily C Dunford, Anastassia Trifonova, Ghoncheh Abdifarkosh, Trevor Teich, Michael C Riddell, Tara L Haas
Glucocorticoids (GC) elicit skeletal muscle capillary rarefaction, which can subsequently impair blood distribution and muscle function; however, the mechanisms have not been established. We hypothesized that CORT would inhibit endothelial cell survival signals but that treatment with the alpha-1 adrenergic receptor inhibitor prazosin, which leads to angiogenesis in skeletal muscle of healthy rats, would reverse these effects and induce angiogenesis within the skeletal muscle of corticosterone (CORT)-treated rats...
2016: PloS One
https://www.readbyqxmd.com/read/27853668/the-effectiveness-and-safety-of-exoskeletons-as-assistive-and-rehabilitation-devices-in-the-treatment-of-neurologic-gait-disorders-in-patients-with-spinal-cord-injury-a-systematic-review
#13
Christian Fisahn, Mirko Aach, Oliver Jansen, Marc Moisi, Angeli Mayadev, Krystle T Pagarigan, Joseph R Dettori, Thomas A Schildhauer
Study Design Systematic review. Clinical Questions (1) When used as an assistive device, do wearable exoskeletons improve lower extremity function or gait compared with knee-ankle-foot orthoses (KAFOs) in patients with complete or incomplete spinal cord injury? (2) When used as a rehabilitation device, do wearable exoskeletons improve lower extremity function or gait compared with other rehabilitation strategies in patients with complete or incomplete spinal cord injury? (3) When used as an assistive or rehabilitation device, are wearable exoskeletons safe compared with KAFO for assistance or other rehabilitation strategies for rehabilitation in patients with complete or incomplete spinal cord injury? Methods PubMed, Cochrane, and Embase databases and reference lists of key articles were searched from database inception to May 2, 2016, to identify studies evaluating the effectiveness of wearable exoskeletons used as assistive or rehabilitative devices in patients with incomplete or complete spinal cord injury...
December 2016: Global Spine Journal
https://www.readbyqxmd.com/read/27846309/use-of-antihypertensive-drugs-and-ischemic-stroke-severity-is-there-a-role-for-angiotensin-ii
#14
Wen Yea Hwong, Michiel L Bots, Sharmini Selvarajah, Zariah Abdul Aziz, Norsima Nazifah Sidek, Wilko Spiering, L Jaap Kappelle, Ilonca Vaartjes
BACKGROUND: The increase in angiotensin II (Ang II) formation by selected antihypertensive drugs is said to exhibit neuroprotective properties, but this translation into improvement in clinical outcomes has been inconclusive. We undertook a study to investigate the relationship between types of antihypertensive drugs used prior to a stroke event and ischemic stroke severity. We hypothesized that use of antihypertensive drugs that increase Ang II formation (Ang II increasers) would reduce ischemic stroke severity when compared to antihypertensive drugs that suppress Ang II formation (Ang II suppressors)...
2016: PloS One
https://www.readbyqxmd.com/read/27846185/single-incision-laparoscopic-appendectomy-by-surgical-trainees
#15
Sang Gyun Suh, Hee Joo Sohn, Beom Gyu Kim, Joong-Min Park, Yoo-Shin Choi, Yong Keum Park, Seung Eun Lee
BACKGROUND: Single-incision laparoscopic appendectomy (SILA) is one of the most commonly performed single port surgeries in the world. However, there are few publications documenting a young resident's experience. The purpose of this study is to investigate clinical outcomes of SILA performed by a surgical trainee and to evaluate its feasibility and safety compared with conventional three-port laparoscopic appendectomy (TPLA) when performed by a surgical trainee and SILA by surgical staff...
December 2016: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/27842568/efficacy-and-safety-of-tension-band-wiring-versus-plate-fixation-in-olecranon-fractures-a-systematic-review-and-meta-analysis
#16
Yi-Ming Ren, Hu-Yun Qiao, Zhi-Jian Wei, Wei Lin, Bao-You Fan, Jun Liu, Ang Li, Yi Kang, Shen Liu, Yan Hao, Xian-Hu Zhou, Shi-Qing Feng
BACKGROUND: Olecranon fracture (OF) is a common upper limb fracture, and the most commonly used techniques are still tension band wiring (TBW) and plate fixation (PF). The aim of the current study is to discuss whether TBW or PF technique of internal fixation is better in the treatment of OFs, using the method of meta-analysis. METHODS: The eligible studies were acquired from PubMed, CNKI, Embase, Cochrane Library, and other sources. The data were extracted by two of the coauthors independently and were analyzed by RevMan5...
November 14, 2016: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/27836804/the-shape-effect-of-magnetic-mesoporous-silica-nanoparticles-on-endocytosis-biocompatibility-and-biodistribution
#17
Dan Shao, Meng-Meng Lu, Ya-Wei Zhao, Fan Zhang, Yong-Fei Tan, Xiao Zheng, Yue Pan, Xuan-Ang Xiao, Zheng Wang, Wen-Fei Dong, Jing Li, Li Chen
: Although the aspect ratio (AR) play a crucial role in determining biological effects of homogeneous nanomaterials, studies available concerning how the shape contributes to biological effect of heterogeneous nanomaterials is limited. To systematically clarify the shape influence on the endocytosis, biocompatibility and biodistribution of magnetic mesoporous silica nanoparticles (M-MSNPs), three FITC-labeled M-MSNPs with different aspect ratio (AR=1, 2, and 4) were specifically designed and constructed through altering the ratios of CTAB/TEOS in a modified so-gel method...
November 9, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27822383/neuronal-nitric-oxide-synthase-in-hypertension-an-update
#18
REVIEW
Yin Hua Zhang
Hypertension is a prevalent condition worldwide and is the key risk factor for fatal cardiovascular complications, such as stroke, sudden cardiac death and heart failure. Reduced bioavailability of nitric oxide (NO) in the endothelium is an important precursor for impaired vasodilation and hypertension. In the heart, NO deficiency deteriorates the adverse consequences of pressure-overload and causes cardiac hypertrophy, fibrosis and myocardial infarction which lead to fatal heart failure and sudden cardiac death...
2016: Clinical Hypertension
https://www.readbyqxmd.com/read/27806985/high-fat-diet-induced-glucose-dysregulation-is-independent-of-changes-in-islet-ace2-in-mice
#19
Harshita Chodavarapu, Kavaljit H Chhabra, Huijing Xia, Vinayak Shenoy, Xinping Yue, Eric Lazartigues
While restoration of ACE2 activity in the pancreas leads to improvement of glycemia in experimental models of type 2 diabetes, global deficiency in ACE2 disrupts β-cell function and impairs glucose tolerance in mice, demonstrating the physiological role of ACE2 in glucose homeostasis. Although the contribution of pancreatic ACE2 to glucose regulation has been demonstrated in genetic models of diabetes and in models with overexpression of the renin-angiotensin system (RAS), it is unclear whether islet ACE2 is involved in glycemic control in common models of human type 2 diabetes...
November 2, 2016: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/27791295/vascular-architecture-as-diagnostic-marker-for-differentiation-of-who-thymoma-subtypes-and-thymic-carcinoma
#20
Frederick Pfister, Hussam Hussain, Djeda Belharazem, Svenja Busch, Katja Simon-Keller, Dominic Becker, Eva Pfister, Ralf Rieker, Philipp Ströbel, Alexander Marx
BACKGROUND: Thymomas and thymic squamous cell carcinomas (TSQCC) are rare thymic epithelial tumors. Data on angiogenesis and vascular phenotype in these tumors is limited, and no study took histological WHO subtypes into account. METHODS: Vascular density, diameter and architecture and expression of SMA, PDGFRb, VEGFR1 and VEGFR2 were investigated in WHO type A, AB, B1, B2 and B3 thymomas and TSQCC, using immuno-stainings, quantitative morphometry and tumor vessel isolation by trypsin digestion...
October 28, 2016: Histopathology
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