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https://www.readbyqxmd.com/read/29679094/depletion-of-angiotensin-converting-enzyme-2-reduces-brain-serotonin-and-impairs-the-running-induced-neurogenic-response
#1
Friederike Klempin, Valentina Mosienko, Susann Matthes, Daniel C Villela, Mihail Todiras, Josef M Penninger, Michael Bader, Robson A S Santos, Natalia Alenina
Physical exercise induces cell proliferation in the adult hippocampus in rodents. Serotonin (5-HT) and angiotensin (Ang) II are important mediators of the pro-mitotic effect of physical activity. Here, we examine precursor cells in the adult brain of mice lacking angiotensin-converting enzyme (ACE) 2, and explore the effect of an acute running stimulus on neurogenesis. ACE2 metabolizes Ang II to Ang-(1-7) and is essential for the intestinal uptake of tryptophan (Trp), the 5-HT precursor. In ACE2-deficient mice, we observed a decrease in brain 5-HT levels and no increase in the number of BrdU-positive cells following exercise...
April 20, 2018: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/29663962/tuberculous-lymphadenitis-is-associated-with-altered-levels-of-circulating-angiogenic-factors
#2
G R Kathamuthu, K Moideen, D Baskaran, G Sekar, S Rathinam, V J Bharathi, G R Ganeshan, S Babu
BACKGROUND: Angiogenic factors are important in granuloma formation and serve as biomarkers in pulmonary tuberculosis (PTB). The relationship between these markers and tuberculous lymphadenitis (TBL) is not known. OBJECTIVE AND DESIGN: To examine the association of vascular endothelial growth factor (VEGF) and angiopoietin (Ang) family molecules in TBL, we measured systemic levels of VEGF-A, C, D, R1 (VEGF-receptor 1), R2, R3, Ang-1, Ang-2 and TIE2 (tyrosine kinase with immunoglobulin-like and epidermal growth factor-like domains 2) levels in TBL, latent tuberculous infection (LTBI) and lymph node culture supernatants (VEGF-A, C and Ang-2) of the same TBL patients...
May 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29660426/coffee-and-tea-drinking-in-relation-to-risk-of-hip-fracture-in-the-singapore-chinese-health-study
#3
Zhaoli Dai, Aizhen Jin, Avril Zixin Soh, Li-Wei Ang, Jian-Min Yuan, Woon-Puay Koh
Meta-analyses of studies conducted among Western populations suggest that coffee consumption does not affect osteoporotic fracture risk. However, experimental studies have shown that the effect of caffeine on bone health may depend on dosage. We examined the associations between consumption of coffee, tea and caffeine and risk of hip fracture in an Asian cohort. In a population-based prospective cohort of 63,257 Chinese men and women aged 45-74 years in Singapore, a validated semi-quantitative food frequency questionnaire was used to assess habitual consumption of coffee and tea at baseline...
April 13, 2018: Bone
https://www.readbyqxmd.com/read/29659570/laboratory-mouse-housing-conditions-can-be-improved-using-common-environmental-enrichment-without-compromising-data
#4
Viola André, Christine Gau, Angelika Scheideler, Juan A Aguilar-Pimentel, Oana V Amarie, Lore Becker, Lillian Garrett, Wolfgang Hans, Sabine M Hölter, Dirk Janik, Kristin Moreth, Frauke Neff, Manuela Östereicher, Ildiko Racz, Birgit Rathkolb, Jan Rozman, Raffi Bekeredjian, Jochen Graw, Martin Klingenspor, Thomas Klopstock, Markus Ollert, Carsten Schmidt-Weber, Eckhard Wolf, Wolfgang Wurst, Valérie Gailus-Durner, Markus Brielmeier, Helmut Fuchs, Martin Hrabé de Angelis
Animal welfare requires the adequate housing of animals to ensure health and well-being. The application of environmental enrichment is a way to improve the well-being of laboratory animals. However, it is important to know whether these enrichment items can be incorporated in experimental mouse husbandry without creating a divide between past and future experimental results. Previous small-scale studies have been inconsistent throughout the literature, and it is not yet completely understood whether and how enrichment might endanger comparability of results of scientific experiments...
April 16, 2018: PLoS Biology
https://www.readbyqxmd.com/read/29658856/pembrolizumab-plus-chemotherapy-in-metastatic-non-small-cell-lung-cancer
#5
Leena Gandhi, Delvys Rodríguez-Abreu, Shirish Gadgeel, Emilio Esteban, Enriqueta Felip, Flávia De Angelis, Manuel Domine, Philip Clingan, Maximilian J Hochmair, Steven F Powell, Susanna Y-S Cheng, Helge G Bischoff, Nir Peled, Francesco Grossi, Ross R Jennens, Martin Reck, Rina Hui, Edward B Garon, Michael Boyer, Belén Rubio-Viqueira, Silvia Novello, Takayasu Kurata, Jhanelle E Gray, John Vida, Ziwen Wei, Jing Yang, Harry Raftopoulos, M Catherine Pietanza, Marina C Garassino
Background First-line therapy for advanced non-small-cell lung cancer (NSCLC) that lacks targetable mutations is platinum-based chemotherapy. Among patients with a tumor proportion score for programmed death ligand 1 (PD-L1) of 50% or greater, pembrolizumab has replaced cytotoxic chemotherapy as the first-line treatment of choice. The addition of pembrolizumab to chemotherapy resulted in significantly higher rates of response and longer progression-free survival than chemotherapy alone in a phase 2 trial. Methods In this double-blind, phase 3 trial, we randomly assigned (in a 2:1 ratio) 616 patients with metastatic nonsquamous NSCLC without sensitizing EGFR or ALK mutations who had received no previous treatment for metastatic disease to receive pemetrexed and a platinum-based drug plus either 200 mg of pembrolizumab or placebo every 3 weeks for 4 cycles, followed by pembrolizumab or placebo for up to a total of 35 cycles plus pemetrexed maintenance therapy...
April 16, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29609847/angiotensin-iv-improves-subnormothermic-machine-perfusion-preservation-of-rat-liver-graft
#6
Donia Tabka, Mohamed Bejaoui, James Javellaud, Jean-Michel Achard, Hassen Ben Abdennebi
This study aims to determine whether Angiotensin IV (Ang IV) addition to Celsior preservation solution could improve hepatic endothelium function and provide better liver protection during subnormothermic machine preservation (SMP). Two experimental models were used: In the first part of the study, rings isolated from rat hepatic artery were preserved in Celsior solution (6 h, 20 °C) with and without Ang IV (10-9  M), then, endothelium-dependent relaxation (EDR) and the concentration of acetylcholine inducing half-maximal relaxation of pre-contracted rings (EC50) were measured...
March 30, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29602193/microvascular-endothelial-function-is-an-independent-predictor-for-albuminuria-progression-among-asians-with-type-2-diabetes-a-prospective-cohort-study
#7
Xiao Zhang, Serena Low, Keven Ang, Yeoh Lee Ying, Subramaniam Tavintharan, Chee Fang Sum, Lim Su Chi
OBJECTIVES: We aim to investigate whether microvascular endothelial dysfunction is an independent predictor for future albuminuria progression in type 2 diabetes (T2DM) cohort. METHODS: 1,098 T2DM patients were clinically assessed at baseline and 3.2-year follow-up. Progression was defined as transition from normo- (albumin-to-creatinine ratio (ACR)<30mg/g) to microalbuminuria (ACR=30-299mg/g) or macroalbuminuria (ACR>300mg/g), or micro- to macroalbuminuria...
March 30, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29601950/association-between-mdr-1-cyp3a4-oprm-1-gene-polymorphisms-and-the-post-caesarean-fentanyl-analgesic-effect-on-chinese-women
#8
Jingliang Zhang, Li Zhang, Xia Zhao, Sheliang Shen, Xiaopan Luo, Yunlong Zhang
OBJECTIVE: Our study aimed to evaluate the association between the multidrug resistance 1 (MDR1 )/cytochrome P450 3A4 (CYP3A4)/μ-opioid receptor (OPRM1 ) gene polymorphisms and the post-caesarean analgesic effect of fentanyl on Chinese women. METHODS: We recruited 240 patients who received lower segment caesarean section surgeries. Sanger sequencing was used to analyze the MDR1 1236C > T/CYP3A4*1G/OPRM1 A118G polymorphisms. We evaluated post-operative fentanyl consumption and the effect of intravenous analgesia in patients with different genotypes...
March 27, 2018: Gene
https://www.readbyqxmd.com/read/29570986/ampk-phosphorylation-of-ace2-in-endothelium-mitigates-pulmonary-hypertension
#9
Jiao Zhang, Jianjie Dong, Marcy Martin, Ming He, Brendan Gongol, Traci L Marin, Lili Chen, Xinxing Shi, Yanjun Yin, Fenqing Shang, Yan Wu, Hsi-Yuan Huang, Jin Zhang, Yu Zhang, Jian Kang, Esteban A Moya, Hsien-Da Huang, Frank L Powell, Zhen Chen, Patricia A Thistlethwaite, Zu-Yi Yuan, John Y-J Shyy
RATIONALE: Endothelial dysfunction plays an integral role in pulmonary hypertension (PH). AMP-activated protein kinase (AMPK) and angiotensin-converting enzyme 2 (ACE2) are crucial in endothelial homeostasis. The mechanism by which AMPK regulates ACE2 in the pulmonary endothelium and its protective role in PH remains elusive. OBJECTIVES: We investigate the role of AMPK phosphorylation of ACE2 Ser-680 in ACE2 stability and decipher the functional consequences of this post-translational modification of ACE2 in endothelial homeostasis and PH...
March 23, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29570421/five-year-follow-up-of-nivolumab-in-previously-treated-advanced-non-small-cell-lung-cancer-results-from-the-ca209-003-study
#10
Scott Gettinger, Leora Horn, David Jackman, David Spigel, Scott Antonia, Matthew Hellmann, John Powderly, Rebecca Heist, Lecia V Sequist, David C Smith, Philip Leming, William J Geese, Dennis Yoon, Ang Li, Julie Brahmer
Purpose In two phase III studies, nivolumab, a programmed death-1 (PD-1) inhibitor antibody, improved overall survival (OS) versus docetaxel in pretreated advanced non-small-cell lung cancer (NSCLC). We report 5-year follow-up results from an early phase I study of nivolumab in this patient population and describe characteristics of 5-year survivors. Patients and Methods Patients with pretreated, advanced NSCLC received nivolumab 1, 3, or 10 mg/kg every 2 weeks in 8-week cycles for up to 96 weeks. OS from the time of first dose was estimated by the Kaplan-Meier method...
March 23, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29568266/normalization-of-blood-pressure-with-spinal-cord-epidural-stimulation-after-severe-spinal-cord-injury
#11
Susan J Harkema, Siqi Wang, Claudia A Angeli, Yangsheng Chen, Maxwell Boakye, Beatrice Ugiliweneza, Glenn A Hirsch
Chronic low blood pressure and orthostatic hypotension remain challenging clinical issues after severe spinal cord injury (SCI), affecting health, rehabilitation, and quality of life. We previously reported that targeted lumbosacral spinal cord epidural stimulation (scES) could promote stand and step functions and restore voluntary movement in patients with chronic motor complete SCI. This study addresses the effects of targeted scES for cardiovascular function (CV-scES) in individuals with severe SCI who suffer from chronic hypotension...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29566148/co-administration-of-resveratrol-with-doxorubicin-in-young-mice-attenuates-detrimental-late-occurring-cardiovascular-changes
#12
Nobutoshi Matsumura, Beshay N Zordoky, Ian M Robertson, Shereen M Hamza, Nirmal Parajuli, Carrie-Lynn M Soltys, Donna L Beker, Marianne K Grant, Maria Razzoli, Alessandro Bartolomucci, Jason R B Dyck
AIMS: Doxorubicin (DOX) is among the most effective chemotherapies used in pediatric cancer patients. However, the clinical utility of DOX is offset by its well-known cardiotoxicity, which often does not appear until later in life. Since hypertension significantly increases the risk of late-onset heart failure in childhood cancer survivors, we investigated whether juvenile DOX exposure impairs the ability to adapt to angiotensin II (Ang II)-induced hypertension later in life as well as treatments that could prevent this...
March 16, 2018: Cardiovascular Research
https://www.readbyqxmd.com/read/29564917/interactive-effects-of-apelin-renin-angiotensin-system-and-nitric-oxide-in-treatment-of-obesity-induced-type-2-diabetes-mellitus-in-male-albino-rats
#13
Maha Mohamed Sabry, Manal Moustafa Mahmoud, Heba Samy Shoukry, Laila Rashed, Samaa Samir Kamar, Mona Mohamed Ahmed
Apelin and its receptor (APJ) are involved in the regulation of a variety of pathophysiological processes. We studied the effect of apelin treatment on obesity-induced type 2 diabetes mellitus (T2DM) and possible interaction between apelin/APJ system and renin-angiotensin system (RAS). Forty eight male albino rats were divided into two groups: control group and diabetic group. Diabetic group was subdivided into: control diabetic, apelin-treated, apelin + losartan-treated, apelin + l-NAME-treated and losartan-treated diabetic subgroup...
March 22, 2018: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29561187/increased-urinary-angiotensin-converting-enzyme-2-ace2-and-neprilysin-nep-in-type-2-diabetic-patients
#14
Sridevi Gutta, Nadja Grobe, Meenasri Kumbaji, Hassan Osman, Mohammad Saklayen, Gengxin Li, Khalid M Elased
ACE2 and NEP are metalloproteases which are highly expressed in the renal proximal tubules. ACE2 and NEP generate renoprotective angiotensin (1-7) from angiotensin II (Ang II) and Ang I, respectively, and therefore could have a major role in chronic kidney disease (CKD). Recent data demonstrated increased urinary ACE2 in diabetic patients with CKD and kidney transplants. We tested the hypothesis that urinary ACE2, NEP and ADAM17 are increased and could be risk predictors of CKD in diabetic patients. Urinary and plasma ACE2, NEP, and ADAM17 were investigated in twenty healthy nondiabetics (ND), and forty diabetic patients with normoalbuminuria (Dnormo), microalbuminuria (Dmicro) and macroalbuminuria (Dmacro) using ELISA, Western blot, fluorogenic and novel mass spectrometric-based enzyme assays...
March 21, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29559373/the-toxicity-and-efficacy-evaluation-of-different-fractions-of-kansui-fry-baked-with-vinegar-on-walker-256-tumor-bearing-malignant-ascites-effusion-rats-and-normal-rats
#15
Jian-Wei Lou, Liang-Liang Cao, Qiao Zhang, Dong-Jing Jiang, Wei-Feng Yao, Bei-Hua Bao, Yu-Dan Cao, Yu-Ping Tang, Li Zhang, Kun Wang, Guan-Cheng Dai
ETHNOPHARMACOLOGICAL RELEVANCE: Kansui, the root of Euphorbia kansui S.L.Liou ex S.B.Ho (E.kansui), is a classical traditional Chinese medicine (TCM) with certain toxicity. According to the theory of TCM, kansui fry-baked with vinegar (VEK) possesses low toxicity and mild diuretic and purgative efficacy. In clinical practice, it is commonly used for the treatment of ascites and oliguria. The present study aimed to evaluate the toxicity and efficacy of different fractions of VEK and reveal the underlying material basis by employing an animal model of malignant ascites effusion (MAE) in rats...
March 17, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29552858/-effect-of-ophiopogonin-d-in-resisting-vascular-endothelial-cell-apoptosis-induced-by-ang%C3%A2-through-up-regulating-cyp2j2-eets
#16
Xiao-Yan Huang, Yu-Guang Wang, Yi Wang, Yue Gao
This study aimed to investigate the effect and mechanism of ophiopogonin D (OP-D) on Ang Ⅱ-induced HUVECs apoptosis, in order to provide a reliable basis for the safety and efficacy of traditional Chinese medicines. The effect of Ang Ⅱ on survival and total proteins content of HUVECs were measured by MTT and Western blotting. The effect of OP-D on Ang Ⅱ-induced lactate dehydrogenase (LDH) release rate in HUVECs was measured by enzyme standard instrument. The effects of OP-D and 11,12-EET on phosphorylation of JNK/c-Jun induced by Ang Ⅱ were measured by Western blot and RT-PCR with the help of JNK specific inhibitor SP600125 and CYP450 isozymes selective inhibitor 6-(2-propargyloxyphenyl) hexanoic acid (PPOH)...
January 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29543659/do-pain-coping-and-pain-beliefs-associate-with-outcome-measures-before-knee-arthroplasty-in-patients-who-catastrophize-about-pain-a-cross-sectional-analysis-from-a-randomized-clinical-trial
#17
Daniel L Riddle, Mark P Jensen, Dennis Ang, James Slover, Robert Perera, Levent Dumenci
BACKGROUND: Pain-coping strategies and appraisals are responses to the pain experience. They can influence patient-reported and physical performance outcome measures in a variety of disorders, but the associations between a comprehensive profile of pain-coping responses and preoperative pain/function and physical performance measures in patients scheduled for knee arthroplasty have not been examined. Patients with moderate to high pain catastrophizing (a pain appraisal approach associated with an exaggerated focus on the threat value of pain) may represent an excellent study population in which to address this knowledge gap...
April 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/29536765/the-first-activation-study-of-a-%C3%AE-carbonic-anhydrase-tweca%C3%AE-from-the-diatom-thalassiosira-weissflogii-is-effectively-activated-by-amines-and-amino-acids
#18
Andrea Angeli, Fatmah A S Alasmary, Sonia Del Prete, Sameh M Osman, Zeid AlOthman, William A Donald, Clemente Capasso, Claudiu T Supuran
The activation of the δ-class carbonic anhydrase (CAs, EC 4.2.1.1) from the diatom Thalassiosira weissflogii (TweCAδ) was investigated using a panel of natural and non-natural amino acids and amines. The most effective activator of TweCAδ was d-Tyr (KA of 51 nM), whereas several other amino acids and amines, such as L-His, L-Trp, d-Trp, dopamine and serotonin were submicromolar activators (KA s from 0.51 to 0.93 µM). The most ineffective activator of TweCAδ was 4-amino-l-Phe (18.9 µM), whereas d-His, l-/d-Phe, l-/d-DOPA, l-Tyr, histamine, some pyridyl-alkylamines, l-adrenaline and aminoethyl-piperazine/morpholine were moderately potent activators (KA s from 1...
December 2018: Journal of Enzyme Inhibition and Medicinal Chemistry
https://www.readbyqxmd.com/read/29535183/insl5-activates-multiple-signalling-pathways-and-regulates-glp-1-secretion-in-nci-h716-cells
#19
Sheng Y Ang, Bronwyn A Evans, Daniel P Poole, Romke Bron, Jesse J DiCello, Ross A D Bathgate, Martina Kocan, Dana S Hutchinson, Roger J Summers
Insulin-like peptide 5 (INSL5) is a newly discovered gut hormone expressed in colonic enteroendocrine L-cells but little is known about its biological function. Here, we show using RT-qPCR and in situ hybridisation that Insl5 mRNA is highly expressed in the mouse colonic mucosa, colocalised with proglucagon immunoreactivity. In comparison, mRNA for RXFP4 (the cognate receptor for INSL5) is expressed in various mouse tissues, including the intestinal tract. We show that the human enteroendocrine L-cell model NCI-H716 cell line, and goblet-like colorectal cell lines SW1463 and LS513 endogenously express RXFP4...
April 2018: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/29531923/the-role-of-vasodilator-receptors-of-renin-angiotensin-system-on-nitric-oxide-formation-and-kidney-circulation-after-angiotensin-ii-infusion-in-renal-ischemia-reperfusion-rats
#20
Maryam Maleki, Jalal Hasanshahi, Fatemeh Moslemi
Background: Nitric oxide (NO) as a vasodilator factor has renoprotective effect against renal ischemia. The balance between angiotensin II (Ang II) and NO can affect kidney homeostasis. The aim of this study was to determine NO alteration in response to renin-Ang system vasodilator receptors antagonists (PD123319; Ang II type 2 receptor antagonist and A779; Mas receptor antagonist) in renal ischemia/reperfusion injury (IRI) in rats. Materials and Methods: Sixty-three Wistar male and female rats were used...
2018: Advanced Biomedical Research
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