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https://www.readbyqxmd.com/read/28316159/-mechanism-of-angiotensin-converting-enzyme-2-overexpression-improving-collagen-synthesis-in-lung
#1
Q J Yang, B B Zheng, N N Sun, M X Pan, Z M Zheng, Y Meng
Objective: To explore the mechanism of angiotensin-converting enzyme 2 (ACE2) overexpression improving collagen synthesis in lung. Methods: Lung fibroblasts of mice over-expressing ACE2 and the wild type (WT) were cultured in vitro and divided into 5 groups: WT-control, WT-AngiotensinⅡ (AngⅡ), ACE2(+ /+) -control, ACE2(+ /+) -AngⅡ and ACE2(+ /+) -AngⅡ+ A779. The protein relative expression levels of ACE2, collagen Ⅰ, nicotinamide adenine dinucleotide phosphate oxidase 4 (NOX4), nucleotide binding and oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3), autophagy-related protein (Beclin1), ubiquitin-binding protein p62 (P62), microtubule-associated proteins light chain 3-Ⅱ (LC3-Ⅱ) were measured by Western blot and triphosadenine (ATP) level was measured by ATP Assay Kit...
March 14, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28285745/experimental-measurements-and-mathematical-modeling-towards-quantification-of-brain-swelling-stress
#2
Stelios Angeli, Triantafyllos Stylianopoulos
Traumatic brain injury results in brain tissue swelling which can be a life threatening condition due to skull confinement. While previous efforts successfully measured the exhibited volume change in brain tissue swelling, no data exist to provide information about the exhibited stresses. In this study, confined compression mechanical testing was employed to measure swelling stress in murine brain tissue samples by varying the ionic concentration of the bathing solutions. Subsequently, computer simulations of the experimental protocol were employed to confirm a triphasic mathematical model describing the effect and provide insights into the experimental data...
March 3, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28282029/distribution-of-pericellular-matrix-molecules-in-the-temporomandibular-joint-and-their-chondroprotective-effects-against-inflammation
#3
Wern Cui Chu, Shipin Zhang, Timothy J Sng, Yu Jie Ong, Wen-Li Tan, Vivien Y Ang, Casper B Foldager, Wei Seong Toh
The objectives of this study were to (1) determine the distribution and synthesis of pericellular matrix (PCM) molecules (collagen VI, collagen IV and laminin) in rat temporomandibular joint (TMJ) and (2) investigate the effects of PCM molecules on chondrocytes against inflammation in osteoarthritis. Four zones (fibrous, proliferating, mature and hypertrophic) of condylar cartilage and three bands (anterior, intermediate and posterior) of disc were analysed by immunohistochemistry for the presence of PCM molecules in rat TMJs...
March 10, 2017: International Journal of Oral Science
https://www.readbyqxmd.com/read/28279521/recombinant-human-ace2-and-the-angiotensin-1-7-axis-as-potential-new-therapies-for-heart-failure
#4
Vaibhav B Patel, Judith N Lezutekong, Xueyi Chen, Gavin Y Oudit
Heart failure (HF) is a common cause of death and disability and a major economic burden in industrialized nations. Heart disease remains the leading cause of death in North America, with ischemic and hypertensive heart disease as the leading cause of HF. Various basic and clinical studies have established the role of an activated renin-angiotensin (Ang) system and Ang II generation in the progression of HF. Inhibition of an activated renin-Ang system using Ang-converting enzyme inhibitors, Ang II type 1 receptor blockers, and mineralocorticoid receptors antagonists have shown clinical benefits in patients with HF, although, largely limited to HF with reduced ejection fraction (HF-rEF)...
December 23, 2016: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28273198/effects-and-mechanisms-of-radiofrequency-ablation-of-renal-sympathetic-nerve-on-anti-hypertension-in-canine
#5
Wei Chen, Xiaohong Tang, Xiaofang Yang, Chunyan Weng, Kan Yang, Juan Wen, Hong Liu, Yang Wu
Background: Radiofrequency ablation of renal sympathetic nerve (RDN) shows effective BP reduction in hypertensive patients while the specific mechanisms remain unclear. Objective: We hypothesized that abnormal levels of norepinephrine (NE) and changes in NE-related enzymes and angiotensinconverting enzyme 2 (ACE2), angiotensin (Ang)-(1-7) and Mas receptor mediate the anti-hypertensive effects of RDN. Methods: Mean values of systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial pressure (MAP) were assessed at baseline and follow-up...
March 6, 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28271528/the-animal-naming-test-an-easy-tool-for-the-assessment-of-hepatic-encephalopathy
#6
Francesca Campagna, Sara Montagnese, Lorenzo Ridola, Marco Senzolo, Sami Schiff, Michele De Rui, Chiara Pasquale, Silvia Nardelli, Ilaria Pentassuglio, Carlo Merkel, Paolo Angeli, Oliviero Riggio, Piero Amodio
BACKGROUND AND AIMS: Screening for hepatic encephalopathy (HE) that does not cause obvious disorientation or asterixis (MHE/grade I HE) is important. We examined if the animal naming test (ANT1 ) (maximum number of animals listed in one minute) is useful in this context. METHODS: In total, 208 healthy controls, 40 controls with inflammatory bowel disease (IBD) and 327 consecutive patients with cirrhosis underwent the ANT1 . The patients were tested for MHE by the psychometric hepatic encephalopathy score (PHES), and 146 were assessed by electroencephalography (EEG); 202 patients were followed up regarding the occurrence of overt HE and death...
March 8, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28260550/quality-of-life-of-malaysian-children-with-chd
#7
Lai C Ong, Ching S Teh, Joyce Darshinee, Asma Omar, Hak L Ang
OBJECTIVES: The objectives of this study were to compare the quality-of-life scores of Malaysian children with CHD and their healthy siblings, to determine the level of agreement between proxy-reports and child self-reports, and to examine variables that have an impact on quality of life in those with CHD. METHODS: Parental-proxy scores of the Pediatric Quality of Life Inventory 4.0 core scales were obtained for 179 children with CHD and 172 siblings. Intra-class coefficients were derived to determine the levels of proxy-child agreement in 66 children aged 8-18 years...
March 6, 2017: Cardiology in the Young
https://www.readbyqxmd.com/read/28258473/sarcopenia-in-rheumatoid-arthritis-prevalence-influence-of-disease-activity-and-associated-factors
#8
Ange Ngeuleu, F Allali, L Medrare, A Madhi, H Rkain, N Hajjaj-Hassouni
Evaluate the prevalence of sarcopenia on patients with rheumatoid arthritis (RA), the influence of sarcopenia on disease activity and factors associated with sarcopenia. One hundred and twenty-three patients aged over 18 years with RA based on the 1987 ACR/EULAR classification criteria were enrolled. We performed a whole body DXA scan using a dual-energy X-ray absorptiometry (DXA) scanner lunar prodigy to measure fat mass, lean mass, and bone mass in the whole body and body parts. According to the anthropometric equation by Baumgartner et al...
March 3, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28242826/gender-differences-in-hypoxic-acclimatization-in-cyclooxygenase-2-deficient-mice
#9
Kui Xu, Xiaoyan Sun, Girriso F Benderro, Constantinos P Tsipis, Joseph C LaManna
The aim of this study was to determine the effect of cyclooxygenase-2 (COX-2) gene deletion on the adaptive responses during prolonged moderate hypobaric hypoxia. Wild-type (WT) and COX-2 knockout (KO) mice of both genders (3 months old) were exposed to hypobaric hypoxia (~0.4 ATM) or normoxia for 21 days and brain capillary densities were determined. Hematocrit was measured at different time intervals; brain hypoxia-inducible factor -1α (HIF-1α), angiopoietin 2 (Ang-2), brain erythropoietin (EPO), and kidney EPO were measured under normoxic and hypoxic conditions...
February 2017: Physiological Reports
https://www.readbyqxmd.com/read/28238760/vascular-and-cellular-changes-accompany-altered-expression-of-angiopoietins-in-placenta-of-non-complicated-art-pregnancies
#10
Ahmed A M Abdel-Hamid, Alaa El-Din L Firgany, Yaser Mesbah, Mona Fm Soliman
BACKGROUND: ART is steadily performed for infertility cases and most of the previous researches have focused on complicated pregnancies. Nonetheless, few ones have concerned with placenta of ART in non-complicated pregnancies. OBJECTIVES: To investigate the expression of angiopoietins (ANG) and their receptor, TIE-2, in placenta of full-term non-complicated pregnancies having ART (n=28) versus those with spontaneous conception (n=28) together with the histological as well as morphometric analysis...
February 24, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28235712/ampk-activation-reduces-the-number-of-atheromata-macrophages-in-apoe-deficient-mice
#11
Jing Wang, Ang Ma, Ming Zhao, Haibo Zhu
BACKGROUND AND AIMS: CC chemokine receptor 2 (Ccr2) governs migration of inflammatory Ly6C(hi) monocytes from the bone marrow (BM) to the circulating blood, which is a key step for macrophage accumulation during progression of atherosclerosis. Hyperlipidemia is often accompanied by low AMP-activated kinase (AMPK) activity and increased expression of Ccr2. The aim of this study was to examine whether there is a link between AMPK and chemokine networks. METHODS: ApoE(-/-) mice were fed a western diet and treated daily with AMPK activators (AICAR, A769662, or Metformin) or vehicle for 10 weeks...
March 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28222221/elastase-2-an-angiotensin-ii-generating-enzyme-contributes-to-increased-ang-ii-in-resistance-arteries-of-mice-with-myocardial-infarction
#12
Christiane Becari, Marcondes A B Silva, Marina T Durand, Cibele M Prado, Eduardo B Oliveira, Mauricio S Ribeiro, Helio C Salgado, Maria Cristina O Salgado, Rita C Tostes
Angiotensin II (Ang II), whose generation largely depends on angiotensin-converting enzyme activity, mediates most of the renin-angiotensin-system effects. Elastase-2 (ELA-2), a chymotrypsin-serine protease elastase family member 2A, alternatively generates Ang II in rat arteries. Myocardial infarction (MI) leads to intense RAS activation, but mechanisms involved on Ang II-generation in resistance arteries are unknown. We hypothesized that ELA-2 contributes to vascular Ang II generation and to cardiac damage in mice submitted to MI...
February 21, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28220122/nf-%C3%AE%C2%BAb-links-tlr2-and-par1-to-soluble-immunomodulator-factor-secretion-in-human-platelets
#13
Pauline Damien, Fabrice Cognasse, Bernard Payrastre, Sherry L Spinelli, Neil Blumberg, Charles-Antoine Arthaud, Marie-Ange Eyraud, Richard P Phipps, Archibald McNicol, Bruno Pozzetto, Olivier Garraud, Hind Hamzeh-Cognasse
The primary toll-like receptor (TLR)-mediated immune cell response pathway common for all TLRs is MyD88-dependent activation of NF-κB, a seminal transcription factor for many chemokines and cytokines. Remarkably, anucleate platelets express the NF-κB machinery, whose role in platelets remains poorly understood. Here, we investigated the contribution of NF-κB in the release of cytokines and serotonin by human platelets, following selective stimulation of TLR2 and protease activated receptor 1 (PAR1), a classical and non-classical pattern-recognition receptor, respectively, able to participate to the innate immune system...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28218456/endothelial-cells-inhibit-the-angiotensin-ii-induced-phenotypic-modulation-of-rat-vascular-fibroblasts
#14
Xu Jia-Ying, Chang Nen-Bin, Li Tao, Jiang Rui, Sun Xiao-Lei, He Yan-Zheng, Jiang Jun
PURPOSE: The phenotypic modulation of vascular adventitial fibroblasts plays an important role in vascular remodeling. Evidence have shown that endothelial cells and adventitial fibroblasts interact under certain conditions. In this study, we investigated the influence of endothelial cells on the phenotypic modulation of adventitial fibroblasts. METHODS: Endothelial cells and adventitial fibroblasts from rat thoracic aorta were cultivated in a co-culture system and adventitial fibroblasts were induced with angiotensin II (Ang II)...
February 20, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28218310/crispr-knockout-rat-cytochrome-p450-3a1-2-model-for-advancing-drug-metabolism-and-pharmacokinetics-research
#15
Jian Lu, Yanjiao Shao, Xuan Qin, Daozhi Liu, Ang Chen, Dali Li, Mingyao Liu, Xin Wang
Cytochrome P450 (CYP) 3A accounts for nearly 30% of the total CYP enzymes in the human liver and participates in the metabolism of over 50% of clinical drugs. Moreover, CYP3A plays an important role in chemical metabolism, toxicity, and carcinogenicity. New animal models are needed to investigate CYP3A functions, especially for drug metabolism. In this report, Cyp3a1/2 double knockout (KO) rats were generated by CRISPR-Cas9 technology, and then were characterized for viability and physiological status. The Cyp3a1/2 double KO rats were viable and fertile, and had no obvious physiological abnormities...
February 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28216458/incidence-of-malignancy-and-fibroid-variants-at-surgery-for-presumed-benign-symptomatic-fibroids
#16
Monique Ramos Damasco, Pui-Wan Kiri Chan, Marnie Slonim, Woun-Eng Catarina Ang, Martin Graham Healey
STUDY OBJECTIVE: In women undergoing hysterectomy or myomectomy for benign gynecology indications, where fibroids were present, to estimate the incidence of (1) leiomyosarcoma (LMS), (2) other uterine pathology (3) the frequency of use of morcellation, both mechanical and manual in laparoscopic, vaginal and laparotomy operative routes. DESIGN: Retrospective study (Canadian Task Force classification II-3). SETTING: The Royal Women's Hospital, Melbourne Australia...
February 16, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28212603/effects-of-renal-denervation-on-cardiac-oxidative-stress-and-local-activity-of-the-sympathetic-nervous-system-and-renin-angiotensin-system-in-acute-myocardial-infracted-dogs
#17
Qiaoli Feng, Chengzhi Lu, Li Wang, Lijun Song, Chao Li, Ravi Chandra Uppada
BACKGROUND: This study sought to evaluate the therapeutic effects of renal denervation (RDN) on acute myocardial infarction (MI) in canines and explore its possible mechanisms of action. METHODS: Eighteen healthy mongrel dogs were randomly assigned to either the control group, the MI group or the MI + RDN group. To assess cardiac function, left ventricular ejection fraction (LVEF), left ventricular end-diastolic dimension (LVEDD), left ventricular end-systolic dimension (LVESD) and fraction shortening (FS) were recorded...
February 17, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28210225/increased-apoptosis-in-the-paraventricular-nucleus-mediated-by-at1r-ras-erk1-2-signaling-results-in-sympathetic-hyperactivity-and-renovascular-hypertension-in-rats-after-kidney-injury
#18
Hongguo Zhu, Lishan Tan, Yumin Li, Jiawen Li, Minzi Qiu, Lanying Li, Mengbi Zhang, Min Liang, Aiqing Li
Background: The central nervous system plays a vital role in the development of hypertension, but the molecular regulatory mechanisms are not fully understood. This study aimed to explore signaling in the paraventricular nucleus (PVN) which might contribute to renal hypertension. Methods: Renal hypertension model was established by five-sixth nephrectomy operation (5/6Nx) in male Sprague Dawley rats. Ten weeks afterwards, they were random assigned to no treatment, or intracerebroventricular injection (ICV) with artificial cerebrospinal fluid, losartan [angiotensin II receptor type 1 (AT1R) antagonist], farnesylthiosalicylic acid (Ras inhibitor), PD98059 (MEK inhibitor), or SB203580 (p38 inhibitor) and Z-DEVD-FMK (caspase-3 inhibitor)...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28196323/nearly-monodisperse-insulator-cs4pbx6-x-cl-br-i-nanocrystals-their-mixed-halide-compositions-and-their-transformation-into-cspbx3-nanocrystals
#19
Quinten A Akkerman, Sungwook Park, Eros Radicchi, Francesca Nunzi, Edoardo Mosconi, Filippo De Angelis, Rosaria Brescia, Prachi Rastogi, Mirko Prato, Liberato Manna
We have developed a colloidal synthesis of nearly monodisperse nanocrystals of pure Cs4PbX6 (X = Cl, Br, I) and their mixed halide compositions with sizes ranging from 9 to 37 nm. The optical absorption spectra of these nanocrystals display a sharp, high energy peak due to transitions between states localized in individual PbX6(4-) octahedra. These spectral features are insensitive to the size of the particles and in agreement with the features of the corresponding bulk materials. Samples with mixed halide composition exhibit absorption bands that are intermediate in spectral position between those of the pure halide compounds...
March 8, 2017: Nano Letters
https://www.readbyqxmd.com/read/28168002/hepatitis-c-virus-seroprevalence-in-the-general-female-population-of-9-countries-in-europe-asia-and-africa
#20
Gary M Clifford, Tim Waterboer, Bolormaa Dondog, You Lin Qiao, Dimitri Kordzaia, Doudja Hammouda, Namory Keita, Nahid Khodakarami, Syed Ahsan Raza, Ang Tshering Sherpa, Witold Zatonski, Michael Pawlita, Martyn Plummer, Silvia Franceschi
BACKGROUND: New oral treatments with very high cure rates have the potential to revolutionize global management of hepatitis C virus (HCV), but population-based data on HCV infection are missing in many low and middle-income countries (LMIC). METHODS: Between 2004 and 2009, dried blood spots were collected from age-stratified female population samples of 9 countries: China, Mongolia, Poland, Guinea, Nepal, Pakistan, Algeria, Georgia and Iran. HCV antibodies were detected by a multiplex serology assay using bead-based technology...
2017: Infectious Agents and Cancer
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