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The role of iodine

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https://www.readbyqxmd.com/read/27904869/value-of-dedicated-head-and-neck-18-f-fdg-pet-ct-protocol-in-detecting-recurrent-and-metastatic-lesions-in-post-surgical-differentiated-thyroid-carcinoma-patients-with-high-serum-thyroglobulin-level-and-negative-131-i-whole-body-scan
#1
Mai Hong Son, Bui Quang Bieu, Le Ngoc Ha
OBJECTIVES: In clinical practice, approximately 10-25% of post-surgical differentiated thyroid carcinoma (DTC) patients with high serum thyroglobulin (Tg) and negative (131)I whole-body scan (WBS) have poor prognosis due to recurrent or metastatic lesions after radioactive iodine treatment. The purpose of this study was to evaluate the value of (18)F-FDG PET/CT scan in DTC patients with high serum Tg level and negative (131)I WBS. METHODS: 69 post-surgical DTC patients with high serum Tg level and negative post ablation (131)I WBS were enrolled in this study...
2016: Asia Oceania Journal of Nuclear Medicine & Biology
https://www.readbyqxmd.com/read/27894786/mr-angiography-can-guide-ed-management-of-suspected-acute-aortic-dissection
#2
Gary X Wang, Sandeep S Hedgire, Thang Q Le, Jonathan D Sonis, Brian J Yun, Michael H Lev, Ali S Raja, Anand M Prabhakar
BACKGROUND: Aortic dissection is typically evaluated with computed tomography angiography (CTA). However, the feasibility of using magnetic resonance angiography (MRA) in the ED is unclear. This study examined the indications and outcomes of MRA in suspected aortic dissection evaluation in the ED. METHODS: An IRB approved review identified patients who underwent MRA in the ED for acute thoracic aortic dissection from January 2010 to June 2016. Demographics, clinical assessment, CTA contraindications, outcomes, and ED disposition were analyzed...
November 17, 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27869417/micronutrients-and-neurodevelopment-an-update
#3
REVIEW
Horacio F González, Silvana Visentin
Micronutrients make up the central nervous system structure and play major functional roles: they stimulate nerve cell development, migration, and differentiation. The goal of this study is to review the scientific literature regarding the role of micronutrients in infant brain structure and function. Thus, we aim at providing pediatricians with knowledge on the importance of introducing all nutrients into the diet based on breast milk composition. The following databases were reviewed: MEDLINE, through PubMed, TRIP Database, and LILACS...
December 1, 2016: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/27846003/imaging-of-prostate-specific-membrane-antigen-expression-in-metastatic-differentiated-thyroid-cancer-using-68ga-hbed-cc-psma-pet-ct
#4
Susanne Lütje, Benedikt Gomez, Joseph Cohnen, Lale Umutlu, Martin Gotthardt, Thorsten D Poeppel, Andreas Bockisch, Sandra Rosenbaum-Krumme
PURPOSE: The prostate-specific membrane antigen (PSMA) was shown to be overexpressed on the neovasculature of several malignancies. Here, the role of Ga-HBED-CC-PSMA PET/CT for the detection of PSMA expression in patients with metastasized differentiated thyroid cancer (DTC) was evaluated. METHODS: Six patients with iodine-negative and F-FDG-positive metastasized DTC (mean TG, 1616 ng/mL) received 71-93 MBq of the Ga-labeled PSMA ligand and underwent PET/CT at 62 ± 7 minutes p...
November 11, 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27831955/ce-preventing-contrast-induced-acute-kidney-injury
#5
Yvonne Gallegos, Asma Ali Taha, Dana N Rutledge
: Diagnostic radiographic imaging scans using intravascular iodinated contrast media can lead to various complications. The most salient of these is contrast-induced acute kidney injury (CI-AKI) or contrast-induced nephropathy, a potentially costly and serious patient safety concern. Prevention strategies are the cornerstone of evidence-based clinical management for patients receiving contrast agents. These include preprocedure screening, stratification of patients based on risk factors, and protective interventions, the most important of which is hydration both before and after the radiographic imaging scan...
December 2016: American Journal of Nursing
https://www.readbyqxmd.com/read/27829313/taz-induction-directs-differentiation-of-thyroid-follicular-cells-from-human-embryonic-stem-cells
#6
Risheng Ma, Syed Morshed, Rauf Latif, Terry F Davies
OBJECTIVE: The differentiation program for human thyroid follicular cells (TFCs) relies on the interplay between sequence-specific transcription factors and transcriptional co-regulators. TAZ (transcriptional co-activator with PDZ-binding motif) is a co-activator that regulates several transcription factors, including PAX8 and NKX2-1, which play a central role in thyroid-specific gene transcription. TAZ and PAX8/NKX2-1 are co-expressed in the nuclei of thyroid cells and TAZ interacts directly with both PAX8 and NKX2-1 leading to their enhanced transcriptional activity on the thyroglobulin (TG) promoter and additional genes...
November 9, 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27825825/changes-in-sk-channel-expression-in-the-basal-ganglia-after-partial-nigrostriatal-dopamine-lesions-in-rats-functional-consequences
#7
Christiane Mourre, Christine Manrique, Jeremy Camon, Sabrine Aidi-Knani, Thierry Deltheil, Nathalie Turle-Lorenzo, Gaelle Guiraudie-Capraz, Marianne Amalric
Parkinson's disease (PD) is a progressive neurodegenerative disease originating from the loss of dopamine (DA) neurons in the substantia nigra pars compacta (SNC). The small-conductance calcium-activated potassium (SK) channels play an essential role in the regulation of midbrain DA neuron activity patterns, as well as excitability of other types of neurons of the basal ganglia. We therefore questioned whether the SK channel expression in the basal ganglia is modified in parkinsonian rats and how this could impact behavioral performance in a reaction time task...
November 5, 2016: Neuropharmacology
https://www.readbyqxmd.com/read/27820928/pulmonary-perfusion-changes-as-assessed-by-contrast-enhanced-dual-energy-computed-tomography-after-endoscopic-lung-volume-reduction-by-coils
#8
Frédéric Lador, Anne-Lise Hachulla, Olivia Hohn, Jérôme Plojoux, Maxime Ronot, Xavier Montet, Paola M Soccal
BACKGROUND: Endoscopic lung volume reduction by coils (LVRC) is a recent treatment approach for severe emphysema. Furthermore, dual-energy computed tomography (DECT) now offers a combined assessment of lung morphology and pulmonary perfusion. OBJECTIVES: The aim of our study was to assess the impact of LVRC on pulmonary perfusion with DECT. METHODS: Seventeen patients (64.8 ± 6.7 years) underwent LVRC. DECT was performed prior to and after LVRC...
2016: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/27803709/iodine-and-selenium-biofortification-with-additional-application-of-salicylic-acid-affects-yield-selected-molecular-parameters-and-chemical-composition-of-lettuce-plants-lactuca-sativa-l-var-capitata
#9
Sylwester Smoleń, Iwona Kowalska, Małgorzata Czernicka, Mariya Halka, Kinga Kęska, Włodzimierz Sady
Iodine (I) and selenium (Se) are included in the group of beneficial elements. They both play important roles in humans and other animals, particularly in the regulation of thyroid functioning. A substantial percentage of people around the world suffer from health disorders related to the deficiency of these elements in the diet. Salicylic acid (SA) is a compound similar to phytohormones and is known to improve the efficiency of I biofortification of plants. The influence of SA on Se enrichment of plants has not, however, been recognized together with its effect on simultaneous application of I and Se to plants...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27797386/femtosecond-charge-and-molecular-dynamics-of-i-containing-organic-molecules-induced-by-intense-x-ray-free-electron-laser-pulses
#10
K Nagaya, K Motomura, E Kukk, Y Takahashi, K Yamazaki, S Ohmura, H Fukuzawa, S Wada, S Mondal, T Tachibana, Y Ito, R Koga, T Sakai, K Matsunami, K Nakamura, M Kanno, A Rudenko, C Nicolas, X-J Liu, C Miron, Y Zhang, Y Jiang, J Chen, M Anand, D E Kim, K Tono, M Yabashi, M Yao, H Kono, K Ueda
We studied the electronic and nuclear dynamics of I-containing organic molecules induced by intense hard X-ray pulses at the XFEL facility SACLA in Japan. The interaction with the intense XFEL pulse causes absorption of multiple X-ray photons by the iodine atom, which results in the creation of many electronic vacancies (positive charges) via the sequential electronic relaxation in the iodine, followed by intramolecular charge redistribution. In a previous study we investigated the subsequent fragmentation by Coulomb explosion of the simplest I-substituted hydrocarbon, iodomethane (CH3I)...
October 31, 2016: Faraday Discussions
https://www.readbyqxmd.com/read/27794246/incidental-papillary-thyroid-carcinoma-in-thyroglossal-duct-cyst-case-report
#11
Ana Karen Lira Medina, Eliseo Fernandez Berdeal, Ernesto Bernal Cisneros, Rebeca Betancourt Galindo, Pamela Frigerio
INTRODUCTION: The thyroglossal cyst is found in 7% of the population and the incidental papillary thyroid carcinoma in thyroglossal cyst is a rare entity with an incidence 1 to 2%. The clinical presentation is indistinguishable from a benign lesion and the histopathological postoperative study defines the diagnosis. Papillary carcinomas have favorable prognosis and cervical or distant metastases are rare. There is now a consensus on the indication of total thyroidectomy, radioablation with iodine and/or suppressive therapy with levothyroxine after being removed surgically [1-3] (Patrucco et al...
October 15, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27792348/metal-free-regioselective-hypervalent-iodine-mediated-c-2-and-c-3-difunctionalization-of-n-substituted-indoles
#12
Dongdong Xu, Wen-Wu Sun, Yanli Xie, Ji-Kai Liu, Bin Liu, Yingbi Zhou, Bin Wu
Mild, metal-free, highly regioselective hypervalent-iodine mediated C-2 acetoxylation and C-3 oxidations of N-substituted indoles with (diacetoxyiodo)benzene [PhI(OAc)2] have been reported. The reaction involves three cascade steps. The quantity of PhI(OAc)2 employed in this reaction plays a key role in the outcome of three types of products (2a-4a). Furthermore, the mild and highly regioselective C-2 oxidation and C-3 dichlorination of N-substituted indoles with PhICl2 have been developed. Extensive studies including in situ IR techniques and H2O18-labeling experiment were performed to gain insight into the possible reaction mechanism...
October 28, 2016: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/27788013/electrosynthesis-using-a-recyclable-mediator-electrolyte-system-based-on-ionically-tagged-phenyl-iodide-and-1-1-1-3-3-3-hexafluoroisopropanol
#13
Timo Broese, Robert Francke
A new type of redox mediator for electrosynthesis based on the iodine(I)/iodine(III) redox couple is reported. It is demonstrated that the use of 1,1,1,3,3,3-hexafluoroisopropanol as solvent plays a crucial role for both the selective anodic generation of the active iodine(III) species and the subsequent chemical transformation. Furthermore, the supporting electrolyte is merged with the mediator by tethering the redox-active iodophenyl moiety to an alkylammonium group, allowing for straightforward recovery and reuse of both components...
October 27, 2016: Organic Letters
https://www.readbyqxmd.com/read/27785740/analysis-of-hair-trace-elements-in-children-with-autism-spectrum-disorders-and-communication-disorders
#14
Anatoly V Skalny, Natalia V Simashkova, Tatiana P Klyushnik, Andrei R Grabeklis, Ivan V Radysh, Margarita G Skalnaya, Alexey A Tinkov
The primary objective of the present study is analysis of hair trace elements content in children with communication disorder (CD) and autism spectrum disorder (ASD). A total of 99 children from control, CD, and ASD groups (n = 33) were examined. All children were additionally divided into two subgroups according to age. Hair levels of trace elements were assessed using inductively coupled plasma mass spectrometry. The difference was considered significant at p < 0.01. The obtained data demonstrate that children with CD are characterized by significantly increased hair lithium (Li) (96 %; p = 0...
October 26, 2016: Biological Trace Element Research
https://www.readbyqxmd.com/read/27773282/ultrasound-synergized-electrostatic-field-extraction-of-total-flavonoids-from-hemerocallis-citrina-baroni
#15
Ri-Fu Yang, Lin-Lin Geng, Hai-Qin Lu, Xiao-Dan Fan
The total flavonoids from Hemerocallis citrina baroni are regarded as a green and natural health care product with many beneficial impacts on human health. In this study, ultrasound-synergized electrostatic field extraction (UEE) of the total flavonoids (TF) from H. citrina was investigated. Significant independent variables of the extraction, including the electrostatic field, ultrasonic power, ethanol concentration and extraction time, were optimized using the Box-Behnken (BB) method, and the optimal extraction conditions were obtained by response surface methodology (RSM)...
January 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/27758131/assessment-of-nutritional-status-of-iodine-through-urinary-iodine-screening-among-local-children-and-adolescents-after-the-fukushima-daiichi-nuclear-power-plant-accident
#16
Masaharu Tsubokura, Shuhei Nomura, Hajime Watanobe, Yoshitaka Nishikawa, Chiaki Suzuki, Sae Ochi, Claire Leppold, Hirokatsu Kinoshita, Shigeaki Kato, Yasutoshi Saito
Background Iodine deficiency is an important modifier of the risk of thyroid cancer following irradiation; however, little information is available on a prevalence of iodine deficiency in Fukushima and its surroundings after the Fukushima Daiichi nuclear power plant accident that occurred in March, 2011. Methods To assess urinary iodine concentrations (UIC) and a prevalence of iodine deficiency and to elucidate any associations between demographic characteristics and UIC levels among children and adolescents aged 18 or younger at the time of the accident in Fukushima Prefecture and its surroundings, we evaluated the data on voluntary UIC testing conducted by Hirata Central Hospital, Fukushima...
October 19, 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27750020/variable-cold-induced-brown-adipose-tissue-response-to-thyroid-hormone-status
#17
Alina Gavrila, Per-Olof Hasselgren, Allison Glasgow, Ashley N Doyle, Alice J Lee, Peter Fox, Shiva Gautam, James V Hennessey, Gerald M Kolodny, Aaron M Cypess
BACKGROUND: In addition to its role in adaptive thermogenesis, brown adipose tissue (BAT) may protect from weight gain, insulin resistance/diabetes, and metabolic syndrome. Prior studies have shown contradictory results regarding the influence of thyroid hormone (TH) levels on BAT volume and activity. The aim of this pilot study was to gain further insights regarding the effect of TH treatment on BAT function in adult humans by evaluating the BAT mass and activity prospectively in six patients, first in the hypothyroid and then in the thyrotoxic phase...
November 29, 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27732333/the-history-of-the-follicular-variant-of-papillary-thyroid-carcinoma
#18
Giovanni Tallini, R Michael Tuttle, Ronald A Ghossein
CONTEXT: The purpose of this review is to provide the historical context to recent developments in the classification of the follicular variant of papillary thyroid carcinoma (FVPTC), an entity that has long created significant controversy. The scope is to illustrate the evolution of the diagnostic criteria for papillary thyroid carcinoma, clarifying the role of molecular analysis, and the impact on patient management. EVIDENCE ACQUISITION: A PubMed search using the terms "follicular variant" and "papillary thyroid carcinoma" covering the years 1960-2016 was performed...
October 12, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27729199/r%C3%A3-le-of-contrast-media-viscosity-in-altering-vessel-wall-shear-stress-and-relation-to-the-risk-of-contrast-extravasations
#19
Sophia Sakellariou, Wenguang Li, Manosh C Paul, Giles Roditi
Iodinated contrast media (CM) are the most commonly used injectables in radiology today. A range of different media are commercially available, combining various physical and chemical characteristics (ionic state, osmolality, viscosity) and thus exhibiting distinct in vivo behaviour and safety profiles. In this paper, numerical simulations of blood flow with contrast media were conducted to investigate the effects of contrast viscosity on generated vessel wall shear stress and vessel wall pressure to elucidate any possible relation to extravasations...
October 8, 2016: Medical Engineering & Physics
https://www.readbyqxmd.com/read/27721494/nlrp3-inflammasome-mediates-contrast-media-induced-acute-kidney-injury-by-regulating-cell-apoptosis
#20
Jianxiao Shen, Ling Wang, Na Jiang, Shan Mou, Minfang Zhang, Leyi Gu, Xinghua Shao, Qin Wang, Chaojun Qi, Shu Li, Wanpeng Wang, Xiajing Che, Zhaohui Ni
Iodinated contrast media serves as a direct causative factor of acute kidney injury (AKI) and is involved in the progression of cellular dysfunction and apoptosis. Emerging evidence indicates that NLRP3 inflammasome triggers inflammation, apoptosis and tissue injury during AKI. Nevertheless, the underlying renoprotection mechanism of NLRP3 inflammasome against contrast-induced AKI (CI-AKI) was still uncertain. This study investigated the role of NLRP3 inflammasome in CI-AKI both in vitro and in vivo. In HK-2 cells and unilateral nephrectomy model, NLRP3 and NLRP3 inflammasome member ASC were significantly augmented with the treatment of contrast media...
October 10, 2016: Scientific Reports
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