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The role of iodine

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https://www.readbyqxmd.com/read/29353104/galactosylated-iodine-based-small-molecule-i-v-ct-contrast-agent-for-bile-duct-imaging
#1
Yeonjin Jung, Hee Sook Hwang, Kun Na
Computed tomography (CT) with contrast plays an important role as a clinical diagnostic tool but still has a limited diagnostic range. In this work, we developed a novel injectable iodine-based small molecule CT contrast agent, even can be used for bile duct diagnostics. The bile duct diagnosable CT contrast agent (BDICA) is synthesized with 5-amino-2,4,6-triiodoisophthaloyl dichloride (ATIPC), tromethamine and lactobionic acid (LBA) for asialoglycoprotein receptor (ASGPR) targeted delivery via receptor-mediated endocytosis and transport to the bile canaliculi...
January 12, 2018: Biomaterials
https://www.readbyqxmd.com/read/29349788/roles-of-water-quality-and-disinfectant-application-on-inactivation-of-fish-pathogenic-streptococcus-agalactiae-with-povidone-iodine-quaternary-ammonium-compounds-and-glutaraldehyde
#2
N Mon-On, W Surachetpong, S Mongkolsuk, K Sirikanchana
Streptococcosis is an important bacterial disease in Nile tilapia causing severe economic losses to tilapia aquaculture worldwide. The effects of water quality (low- [LS] and high-level [HS] soiling, to mimic clean or dirty surface conditions and temperatures) and disinfectant application (diluted concentrations and exposure time) were characterized on the inactivation of Streptococcus agalactiae isolated from diseased tilapia. Five isolates were tested against three commercial disinfectant products with the main ingredients being povidone iodine (Anidine 100™; AD), benzalkonium chloride (Better BKC 80%™; BKC 80), and a mixture of quaternary ammonium compounds and glutaraldehyde (Chloraldehyde™; CR)...
January 19, 2018: Journal of Fish Diseases
https://www.readbyqxmd.com/read/29340973/reference-intervals-for-thyrotropin-in-an-area-of-northern-italy-the-pordenone-thyroid-study-tripp
#3
R Tozzoli, F D'Aurizio, P Metus, A Steffan, C Mazzon, M Bagnasco
PURPOSE: Thyrotropin (TSH) is the most accurate marker of thyroid dysfunction in the absence of pituitary or hypothalamic disease. Studies on TSH reference intervals (RIs) showed wide inter-individual variability and prompted an intense debate about the best estimation of TSH RIs. DESIGN: We performed a population study on TSH RIs, using current data stored in the laboratory information system (LIS), at the Hospital Department of Laboratory Medicine, Pordenone (Italy), historically an area of mild-moderate iodine deficiency with a relatively high goiter prevalence...
January 16, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29334343/breast-milk-iodine-concentrations-and-iodine-levels-of-infants-according-to-the-iodine-status-of-the-country-of-residence-a-systematic-review-and-meta-analysis
#4
Pantea Nazeri, Ali Kabir, Hosein Dalili, Parvin Mirmiran, Fereidoun Azizi
BACKGROUND: Iodine, an essential micronutrient, plays a critical role in normal growth and development, especially during the first two years of life. This systematic review and meta-analysis is among the first to evaluate breast-milk iodine concentrations and infant iodine status in countries characterized by iodine sufficiency or deficiency. METHODS: PubMed, Web of Science, Cochrane Library, Google Scholar, and other relevant databases, as well as reference lists of previous reviews, were searched for relevant studies published between 1986 and 2016...
January 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29329593/targeting-ectodysplasin-promotor-by-crispr-dcas9-effector-effectively-induces-the-reprogramming-of-human-bone-marrow-derived-mesenchymal-stem-cells-into-sweat-gland-like-cells
#5
Sujing Sun, Jun Xiao, Jiahui Huo, Zhijun Geng, Kui Ma, Xiaoyan Sun, Xiaobing Fu
BACKGROUND: Patients with a deep burn injury are characterized by losing the function of perspiration and being unable to regenerate the sweat glands. Because of their easy accession, multipotency, and lower immunogenicity, bone marrow-derived mesenchymal stem cells (BM-MSCs) represent as an ideal biological source for cell therapy. The aim of this study was to identify whether targeting the promotor of ectodysplasin (EDA) by CRISPR/dCas9-effector (dCas9-E) could induce the BM-MSCs to differentiate into sweat gland-like cells (SGCs)...
January 12, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29317481/iaps-cause-resistance-to-trail-dependent-apoptosis-in-follicular-thyroid-cancer
#6
Thomas Artur Werner, Inga Nolten, Levent Dizdar, Jasmin Riemer, Sina Christin Schütte, Pablo Emilio Verde, Katharina Raba, Matthias Schott, Wolfram Trudo Knoefel, Andreas Krieg
Follicular thyroid cancer's (FTC) excellent long-term prognosis is mainly dependent on complete surgical removal and postoperative radioactive iodine (RAI) treatment. However, once the tumour becomes RAI refractory the 10-year disease specific survival rate drops below 10 %. The aim of our study was to evaluate the prognostic and biological role of the TRAIL system in FTC and to elucidate the influence of small molecule mediated antagonization of inhibitor of apoptosis proteins (IAPs) on TRAIL-sensitivity in vitro...
January 9, 2018: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29285620/effect-of-the-combined-treatment-of-albumin-with-plasma-synthesised-pyrrole-polymers-on-motor-recovery-after-traumatic-spinal-cord-injury-in-rats
#7
Omar Fabela-Sánchez, Hermelinda Salgado-Ceballos, Luis Medina-Torres, Laura Álvarez-Mejía, Stephany Sánchez-Torres, Rodrigo Mondragón-Lozano, Axayácatl Morales-Guadarrama, Araceli Díaz-Ruiz, María-Guadalupe Olayo, Guillermo J Cruz, Juan Morales, Camilo Ríos, Roberto Olayo
Traumatic spinal cord injury (TSCI) is a health problem for which there is currently no treatment or definitive therapy. Medicine has explored therapeutic options for patients with TSCI with the aim to improve their quality of life. One alternative has been the development of biomaterials that offer neuroprotection or neuroregeneration of damaged nerve tissue. The microinjection of iodine-doped polypyrrole particles synthesised by plasma (PPPy/I) has shown neuroprotective effects that favour motor function recovery in experimental animals with TSCI...
December 28, 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/29243843/signaling-cascades-in-thyroid-cancer-increasing-the-armory-of-archers-to-hit-bullseye
#8
Faiza Abdul Rashid, Qaisar Mansoor, Hafsa Aziz, Sobia Tabassum, Waleed O Arfat, George E Naoum, Muhammad Ismail, Ammad Ahmad Farooqi
Thyroid cancer is a multifaceted and therapeutically challenging disease and rapidly accumulating experimentally verified findings have considerably improve our understanding of the molecular mechanisms which underlie its development. Substantial fraction of information has been added into existing landscape of molecular oncology and we have started to develop a sharper understanding of the underlying mechanisms of thyroid cancer. Wealth of information demystified different intracellular signaling cascades which are frequently deregulated in thyroid cancer...
December 15, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29241733/autophagy-regulates-high-concentrations-of-iodide-induced-apoptosis-in-sh-sy5y-cells
#9
Bin Zhang, Yushan Cui, Lingzhi Wang, Liang Zhao, Changchun Hou, Qiang Zeng, Zushan Zhang, Jingwen Yu, Yang Zhao, Junyan Nie, Xuemin Chen, Aiguo Wang, Hongliang Liu
To date, there are many people residing in areas with high levels of iodide in water. Our previous epidemiological study showed that exposure to high iodine in drinking water significantly reduced the intelligence of children although the mechanisms remain unclear. To explore whether high concentrations of iodide may cause cytotoxic effect and the role of autophagy in the high iodide-induced apoptosis, human neuroblastoma cells (SH-SY5Y cells) were exposed to high concentrations of iodide. Morphological phenotypes, cell viability, Hoechst 33258 staining, the expression levels of apoptosis and autophagy-related proteins were detected...
December 11, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/29237517/hypopharyngeal-cancer-associated-with-synchronous-oesophageal-cancer-risk-factors-and-benefits-of-image-enhanced-endoscopic-screening
#10
X-G Ni, Q-Q Zhang, J-Q Zhu, G-Q Wang
OBJECTIVES: To explore the risk factors associated with the occurrence of synchronous oesophageal cancer in patients with hypopharyngeal cancer, and to investigate the roles of image-enhanced endoscopic screening in the prediction and diagnosis of early oesophageal cancer. METHODS: The clinical characteristics of patients with hypopharyngeal cancer (n = 160) were analysed. All patients underwent laryngoscopic and gastroscopic examination using image-enhanced endoscopic techniques before treatment...
December 14, 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/29234476/syntheses-structures-and-stabilities-of-aliphatic-and-aromatic-fluorous-iodine-i-and-iodine-iii-compounds-the-role-of-iodine-lewis-basicity
#11
Tathagata Mukherjee, Soumik Biswas, Andreas Ehnbom, Subrata K Ghosh, Ibrahim El-Zoghbi, Nattamai Bhuvanesh, Hassan S Bazzi, John A Gladysz
The title molecules are sought in connection with various synthetic applications. The aliphatic fluorous alcohols Rfn CH2OH (Rfn = CF3(CF2) n-1; n = 11, 13, 15) are converted to the triflates Rfn CH2OTf (Tf2O, pyridine; 22-61%) and then to Rfn CH2I (NaI, acetone; 58-69%). Subsequent reactions with NaOCl/HCl give iodine(III) dichlorides Rfn CH2ICl2 (n = 11, 13; 33-81%), which slowly evolve Cl2. The ethereal fluorous alcohols CF3CF2CF2O(CF(CF3)CF2O) x CF(CF3)CH2OH (x = 2-5) are similarly converted to triflates and then to iodides, but efforts to generate the corresponding dichlorides fail...
2017: Beilstein Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29219161/the-atomic-level-mechanism-of-white-phosphorous-demolition-by-di-iodine
#12
Carlo Mealli, Andrea Ienco, Maurizio Peruzzini, Gabriele Manca
A detailed mechanism of the I2-induced transformation of white phosphorus into PI3 emerges from a DFT analysis. This multi-step process implies that at any stage one P-P and two I-I bonds cleavages, associated with the formation of two P-I bonds plus an in situ generated brand new I2 molecule. Significant electron transfer between the atoms is observed at any step, but the reactions are better defined as concerted rather than redox. Along the steepest descent to the product, no significant barrier is encountered except for the very first P4 activation, which costs +14...
December 8, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29216866/cross-sectional-study-of-serum-selenium-concentration-and-esophageal-squamous-dysplasia-in-western-kenya
#13
Natalie R Pritchett, Stephen L Burgert, Gwen A Murphy, John D Brockman, Russell E White, Justus Lando, Robert Chepkwony, Mark D Topazian, Christian C Abnet, Sanford M Dawsey, Michael M Mwachiro
BACKGROUND: Low serum selenium status has been associated with increased risk of esophageal squamous cell carcinoma (ESCC). East Africa is a region of high ESCC incidence and is known to have low soil selenium levels, but this association has not previously been evaluated. In this study we assessed the association of serum selenium concentration and the prevalence of esophageal squamous dysplasia (ESD), the precursor lesion of ESCC, in a cross-sectional study of subjects from Bomet, Kenya...
December 8, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29216296/correction-the-potential-role-of-kelp-forests-on-iodine-speciation-in-coastal-seawater
#14
Jennifer Gonzales, Teresa Tymon, Frithjof C Küpper, Matthew S Edwards, Carl J Carrano
[This corrects the article DOI: 10.1371/journal.pone.0180755.].
2017: PloS One
https://www.readbyqxmd.com/read/29209273/updates-on-the-management-of-advanced-metastatic-and-radioiodine-refractory-differentiated-thyroid-cancer
#15
REVIEW
Dario Tumino, Francesco Frasca, Kate Newbold
Differentiated thyroid cancer (DTC) accounts for 95% of all thyroid cancers and is generally an indolent tumor, treated effectively with surgery, radioactive iodine, and thyroid-stimulating hormone suppressive therapy. However, 5-10% of patients have advanced disease, with aerodigestive tract invasion, distant metastases, or radioiodine refractory disease, with poor prognosis. This review focuses on the approaches for treating advanced DTC, including management of gross extra-thyroidal extension, recurrent loco-regional or distant metastatic disease, the role of external beam radiation therapy and systemic treatment...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29200262/on-surface-growth-dynamics-of-graphene-nanoribbons-the-role-of-halogen-functionalization
#16
Marco Di Giovannantonio, Okan Deniz, José I Urgel, Roland Widmer, Thomas Dienel, Samuel Stolz, Carlos Sánchez-Sánchez, Matthias Muntwiler, Tim Dumslaff, Reinhard Berger, Akimitsu Narita, Xinliang Feng, Klaus Müllen, Pascal Ruffieux, Roman Fasel
On-surface synthesis is a powerful route toward the fabrication of specific graphene-like nanostructures confined in two dimensions. This strategy has been successfully applied to the growth of graphene nanoribbons of diverse width and edge morphology. Here, we investigate the mechanisms driving the growth of 9-atom wide armchair graphene nanoribbons by using scanning tunneling microscopy, fast X-ray photoelectron spectroscopy, and temperature-programmed desorption techniques. Particular attention is given to the role of halogen functionalization (Br or I) of the molecular precursors...
December 4, 2017: ACS Nano
https://www.readbyqxmd.com/read/29194287/expression-of-adamts2-and-adamts5-in-the-salivary-gland-of-rats-after-radioiodine-therapy
#17
Murat Sadic, Koray Demirel, Sevil O Halacli, Emre Karakok, Gokhan Koca, Ozgur Ekinci, Kadir Demircan, Meliha Korkmaz
OBJECTIVE: The aim of this study was to investigate the presence of ADAMTS2 and ADAMTS5 in the salivary gland (SG) of rats after high-dose radioiodine therapy. METHODS: A total of 36 male Wistar albino rats were used for this study. Thirty-six male rats were divided randomly into six groups: control and five radioactive iodine (RAI) treatment groups of six rats each. All animals were killed. The evaluation of biodistribution and histopathological studies were carried out on the SGs removed...
November 29, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29191749/design-and-verification-of-halogen-bonding-system-at-the-complex-interface-of-human-fertilization-related-mup-pdz5-domain-with-camk-s-c-terminal-peptide
#18
Juan Wang, Yunjie Guo, Xue Zhang
Calmodulin-dependent protein kinase (CAMK) is physiologically activated in fertilized human oocytes and is involved in the Ca2+ response pathways that link the fertilization calmodulin signal to meiosis resumption and cortical granule exocytosis. The kinase has an unstructured C-terminal tail that can be recognized and bound by the PDZ5 domain of its cognate partner, the multi-PDZ domain protein (MUP). In the current study, we reported a rational biomolecular design of halogen-bonding system at the complex interface of CAMK's C-terminal peptide with MUP PDZ5 domain by using high-level computational approaches...
November 21, 2017: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/29187856/a-role-for-iodide-and-thyroglobulin-in-modulating-the-function-of-human-immune-cells
#19
Mahmood Y Bilal, Svetlana Dambaeva, Joanne Kwak-Kim, Alice Gilman-Sachs, Kenneth D Beaman
Iodine is an essential element required for the function of all organ systems. Although the importance of iodine in thyroid hormone synthesis and reproduction is well known, its direct effects on the immune system are elusive. Human leukocytes expressed mRNA of iodide transporters (NIS and PENDRIN) and thyroid-related proteins [thyroglobulin (TG) and thyroid peroxidase (TPO)]. The mRNA levels of PENDRIN and TPO were increased whereas TG transcripts were decreased post leukocyte activation. Flow cytometric analysis revealed that both PENDRIN and NIS were expressed on the surface of leukocyte subsets with the highest expression occurring on monocytes and granulocytes...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29184536/insulin-resistance-any-role-in-the-changing-epidemiology-of-thyroid-cancer
#20
REVIEW
Roberta Malaguarnera, Veronica Vella, Maria Luisa Nicolosi, Antonino Belfiore
In the past few decades, the incidence of thyroid cancer (TC), namely of its papillary hystotype (PTC), has shown a steady increase worldwide, which has been attributed at least in part to the increasing diagnosis of early stage tumors. However, some evidence suggests that environmental and lifestyle factors can also play a role. Among the potential risk factors involved in the changing epidemiology of TC, particular attention has been drawn to insulin-resistance and related metabolic disorders, such as obesity, type 2 diabetes, and metabolic syndrome, which have been also rapidly increasing worldwide due to widespread dietary and lifestyle changes...
2017: Frontiers in Endocrinology
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