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The role of iodine

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https://www.readbyqxmd.com/read/29771756/thyrotropin-receptor-antibodies-an-overview
#1
Anupam Kotwal, Marius Stan
PURPOSE: Thyroid autoimmunity affects approximately 5% of the population, and its investigation relies heavily on the use of autoantibodies. Thyroid stimulating hormone receptor (TSHR) autoantibodies (TRAb) play a central role in the evaluation of Graves disease (GD), Graves ophthalmopathy (GO) and pretibial myxedema (PTM). However, there is still controversy regarding overall TRAb assay diagnostic accuracy and their prognostic utility. METHODS: We reviewed and analyzed the literature reporting TRAb assays and their clinical utility...
May 2, 2018: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29769067/antioxidant-capacity-of-cinnamon-extract-for-palm-oil-stability
#2
Muhammad Zia Shahid, Hafiza Saima, Adeela Yasmin, Muhammad Tahir Nadeem, Muhammad Imran, Muhammad Afzaal
BACKGROUND: Spices and their bioactive components are more promising attractions for their inclusion in diet-based regimes to improve human health. These are sources of natural antioxidants and play an important role in the chemoprevention of diseases and aging. The aim of the current study was to explore the antioxidant potential of cinnamon; a widely used spice throughout the world. METHODS: The current research was aimed to investigate the antioxidant potential of cinnamon extract...
May 16, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29757392/thyroid-function-in-early-pregnancy-child-iq-and-autistic-traits-a-meta-analysis-of-individual-participant-data
#3
Deborah Levie, Tim I M Korevaar, Sarah C Bath, Albert Dalmau-Bueno, Mario Murcia, Mercedes Espada, Mariana Dineva, Jesús M Ibarluzea, Jordi Sunyer, Henning Tiemeier, Marisa Rebagliato, Margaret P Rayman, Robin P Peeters, Mònica Guxens
Context: Low maternal free thyroxine (FT4) has been associated with poor child neurodevelopment in some single-centre studies. Evidence remains scarce for potential adverse effects of high FT4 and whether associations differ in countries with a different iodine status. Objective: To assess the association of maternal thyroid function in early pregnancy with child neurodevelopment in countries with a different iodine status. Design, Setting and Participants: Meta-analysis of individual-participant data compromising 9,036 mother-child pairs from three prospective population-based birth cohorts: INMA (Spain), Generation R (The Netherlands) and ALSPAC (United Kingdom)...
May 10, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29745980/preparation-of-novel-iodized-salt-with-natural-iodine-rich-sources-by-spray-drying
#4
Han Sol Doh, Jung A Ko, Hyun Jin Park
Marine products are rich in not only micronutrients but also iodine content. However, the applications of iodine in marine products in the food industry have not been studied extensively. Therefore, in this study, a novel iodized salt was prepared through a simple method for iodine extraction from natural iodine-rich sources and spray drying. Laminaria ochroleuca (kombu), Porphyra umbilicalis (nori), Undaria pinnatifida (wakame), and Haliotis discus hannai (abalone) were selected as natural iodine-rich sources...
May 10, 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29742982/the-nfe2-related-transcription-factor-2-nrf2-coordinates-antioxidant-defense-with-thyroglobulin-production-and-iodination-in-the-thyroid-gland
#5
Panos G Ziros, Ioannis Habeos, Dionysios V Chartoumpekis, Eleni Ntalampyra, Emmanuel Somm, Cédric O Renaud, Massimo Bongiovanni, Ioannis P Trougakos, Masayuki Yamamoto, Thomas W Kensler, Pilar Santisteban, Nancy Carrasco, Carrie Ris-Stalpers, Elena Amendola, Xiao-Hui Liao, Luciano Rossich, Lisa Thomasz, Guillermo Juan Juvenal, Samuel Refetoff, Gerasimos P Sykiotis
BACKGROUND: The thyroid gland has a special relationship with oxidative stress. While generation of oxidative substances is part of normal iodide metabolism during thyroid hormone synthesis, the gland must also defend itself against excessive oxidation in order to maintain normal function. Although antioxidant and detoxification enzymes presumably aid thyroid cells to maintain homeostasis by ameliorating oxidative insults, including under conditions of exposure to excess iodide, the factors that coordinate their expression with the cellular redox status are not known...
May 10, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29738593/bilateral-keratoconus-induced-by-secondary-hypothyroidism-after-radioactive-iodine-therapy
#6
Ramon Lee, Farhad Hafezi, J Bradley Randleman
PURPOSE: To present a case of new-onset, bilateral, rapidly progressive keratoconus induced by secondary hypothyroidism after radioactive iodine therapy during the sixth decade of life that was successfully treated with corneal cross-linking. METHODS: Case report and literature review. RESULTS: A 53-year-old woman with no ocular complaints but with a history of Graves' disease and thyrotoxicosis was treated with radioactive iodine therapy and oral levothyroxine for secondary acquired hypothyroidism 3 years prior...
May 1, 2018: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/29732519/comprehensive-assessment-of-takotsubo-cardiomyopathy-by-cardiac-computed-tomography
#7
Daisuke Sueta, Seitaro Oda, Yasuhiro Izumiya, Koichi Kaikita, Masafumi Kidoh, Daisuke Utsunomiya, Yasuyuki Yamashita, Kenichi Tsujita
Cardiac computed tomography (CT) now plays an important role in emergency settings because of its accessibility and fast acquisition time, which cardiac magnetic resonance imaging (CMR) cannot match. Although cardiac CT was originally conceived for the assessment of the coronary artery tree, it has evolved to embrace several non-coronary applications. These include myocardial assessment, resulting in myocardial characterization comparable with that of CMR and cardiac CT for late enhancement imaging. In this report, we describe a patient with takotsubo cardiomyopathy who underwent a comprehensive assessment using cardiac CT...
May 7, 2018: Emergency Radiology
https://www.readbyqxmd.com/read/29718033/center-iodized-graphene-as-an-advanced-anode-material-to-significantly-boost-the-performance-of-lithium-ion-batteries
#8
Jie Chen, Mao-Wen Xu, Jinggao Wu, Chang Ming Li
Iodine edge-doped graphene can improve the capacity and stability of lithium-ion batteries (LIBs). Our theoretical calculations indicate that center-iodization can further significantly enhance the anode catalytic process. To experimentally prove the theoretical prediction, iodine-doped graphene materials were prepared by one-pot hydrothermal and ball-milling approaches to realize different doping-sites. Results show that the center-iodinated graphene (CIG) anode exhibits a remarkably high reversible capacity (1121 mA h g-1 after 180 cycles at 0...
May 2, 2018: Nanoscale
https://www.readbyqxmd.com/read/29704906/contemporary-challenges-to-iodine-status-and-nutrition-the-role-of-foods-dietary-recommendations-fortification-and-supplementation
#9
M Bouga, M E J Lean, E Combet
Iodine deficiency (ID) in women of childbearing age remains a global public health concern, mainly through its impact on fetal and infant neurodevelopment. While iodine status is improving globally, ID is still prevalent in pregnancy, when requirements increase. More than 120 countries have implemented salt iodisation and food fortification, strategies that have been partially successful. Supplementation during pregnancy is recommended in some countries and supported by the WHO when mandatory salt iodisation is not present...
April 29, 2018: Proceedings of the Nutrition Society
https://www.readbyqxmd.com/read/29697470/update-on-techniques-to-prevent-infections-associated-with-prostate-needle-biopsy
#10
Matteo Fontana, Luca Boeri, Emanuele Montanari
PURPOSE OF REVIEW: Postbiopsy infections (PBIs) are among the most common complications associated with transrectal ultrasound-guided prostate biopsy (TRUSPB). This article discusses the pathogenesis of TRUSPB-associated infectious complications and reviews the most recent findings on techniques to prevent PBIs. RECENT FINDINGS: Risk stratification is a powerful tool for identifying TRUSPB candidates whom warrant additional preventive measures. Bowel preparation with povidone-iodine-based enemas and needle disinfection with formalin solution are simple and attractive strategies, but their effectiveness needs to be thoroughly assessed...
April 24, 2018: Current Opinion in Urology
https://www.readbyqxmd.com/read/29680838/mitophagy-plays-a-protective-role-in-iodinated-contrast-induced-acute-renal-tubular-epithelial-cells-injury
#11
Rong Lei, Fei Zhao, Cheng-Yuan Tang, Min Luo, Shi-Kun Yang, Wei Cheng, Xu-Wei Li, Shao-Bin Duan
BACKGROUND/AIMS: Contrast induced-acute kidney injury (CI-AKI) is one of the most common causes of acute kidney injury (AKI) in hospitalized patients. Mitophagy, the selective elimination of mitochondria via autophagy, is an important mechanism of mitochondrial quality control in physiological and pathological conditions. In this study, we aimed to determine effects of iohexol and iodixanol on mitochondrial reactive oxygen species (ROS), mitophagy and the potential role of mitophagy in CI-AKI cell models...
2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29673971/changes-in-trophoblasts-gene-expression-in-response-to-perchlorate-exposition
#12
De la Peña Sol, Santiago-Roque Isela, Olivo-Vidal Zendy, Navarro-Meza Mónica, Xochihua-Rosas Irene, Arroyo-Helguera Omar
Contaminated water with chlorates is a public health problem associated with iodine deficiency. Epidemiological evidence shows that iodine deficiency is a risk factor for preeclampsia (PE). In this study we use human BeWo trophoblast cells exposed to perchlorate (KClO4 ) and changes in gene expression were analyzed by microarrays, quantitative RT-PCR (qRT-PCR) and immunoblot. The microarray analysis identified 48 transcripts up-regulated and 112 down-regulated in comparison with non-exposed trophoblast. The qRT-PCR analysis confirmed changes in GAS7, PKP2, Emilin, Dynatic 3, protocadherins 11, 15, gamma A12, EGFR, SAFB1, ACE2, ANXA2, Apoliprotein E, SREBF1, and C/EBP-β...
April 16, 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/29665575/role-of-fungal-laccase-in-iodide-oxidation-in-soils
#13
Reiko Nihei, Mizuki Usami, Taro Taguchi, Seigo Amachi
Previously, we hypothesized that microbial laccase oxidizes iodide (I- ) in soils to molecular iodine (I2 ) or hypoiodous acid (HIO), both of which are easily incorporated into natural soil organic matter, and thus plays a role in iodine sorption on soils. In this study, soil iodide oxidase activity was determined by a colorimetric assay to evaluate if laccase is responsible for iodide oxidation in soils. Three types of Japanese soil showed significant iodide oxidase activities (0.751-2.87 mU g soil-1 ) at pH 4...
April 14, 2018: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/29662563/-123-i-labeled-oxldl-is-widely-distributed-throughout-the-whole-body-in-mice
#14
Atushi Nakano, Hidekazu Kawashima, Yoshinori Miyake, Tsutomu Zeniya, Akihide Yamamoto, Kazuhiro Koshino, Takashi Temma, Tetsuya Fukuda, Yoshiko Fujita, Akemi Kakino, Shigehiko Kanaya, Tatsuya Sawamura, Hidehiro Iida
Purpose: Oxidized low-density lipoprotein (oxLDL) plays a key role in endothelial dysfunction, vascular inflammation, and atherogenesis. The aim of this study was to assess blood clearance and in vivo kinetics of radiolabeled oxLDL in mice. Methods: We synthesized 123 I-oxLDL by the iodine monochloride method, and performed an uptake study in CHO cells transfected with lectin-like oxLDL receptor-1 (LOX-1). In addition, we evaluated the consistency between the 123 I-oxLDL autoradiogram and the fluorescence image of DiI-oxLDL after intravenous injection for both spleen and liver...
April 2018: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29659059/high-electrical-conductivity-of-single-metal-organic-chains
#15
Pablo Ares, Pilar Amo-Ochoa, José M Soler, Juan José Palacios, Julio Gómez-Herrero, Félix Zamora
Molecular wires are essential components for future nanoscale electronics. However, the preparation of individual long conductive molecules is still a challenge. MMX metal-organic polymers are quasi-1D sequences of single halide atoms (X) bridging subunits with two metal ions (MM) connected by organic ligands. They are excellent electrical conductors as bulk macroscopic crystals and as nanoribbons. However, according to theoretical calculations, the electrical conductance found in the experiments should be even higher...
April 16, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29652048/-should-a-doctor-take-into-consideration-the-influence-of-climatic-factors-deliberations-on-the-occasion-of-the-publication-of-a-new-monograph-the-book-of-essays-of-arid-medicine-by-z-r-zununov-i-h-nurov-and-s-z-zununova
#16
E L Povazhnaya
The authors analyze the monograph of the Uzbek scientists professor Z.R. Zununov, I.H. Nurov, and S.Z. Zununova «Essays of arid medicine» (Tashkent: «KAMALAK-PRESS» publishing house, 2016;540). The book presents the results of the comprehensive bioclimatic assessment of the arid zones of Uzbekistan, their extreme climatic conditions (such as high intensity and solar radiation and the considerable duration of its period, dry air and summer heat, sandstorms (the so-called «Afghans»), and the great variety of the natural health-improving factors including mineral waters, microclimate of the speleotherapeutic cave, the desert dune sand, etc...
April 9, 2018: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
https://www.readbyqxmd.com/read/29650270/radioiodine-refractory-differentiated-thyroid-cancer
#17
REVIEW
Yuchen Jin, Douglas Van Nostrand, Lingxiao Cheng, Min Liu, Libo Chen
Differentiated thyroid cancer (DTC) is usually curable with surgery, radioactive iodine (RAI), and thyroid-stimulating hormone (TSH) suppression. However, local recurrence and/or distant metastases occur in approximately 15% of cases during follow-up, and nearly two-thirds of these patients will become RAI-refractory (RR-DTC) with a poor prognosis. This review focuses on the most challenging and rapidly evolving aspects of RR-DTC, and we discuss the considerable improvement in more accurately defining RR-DTC, more effective therapeutic strategies, and describe the diagnosis, pathogenesis, and future prospects of RR-DTC...
May 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29649642/is-cervical-anterior-spinal-artery-compromised-in-cervical-spondylotic-myelopathy-patients-dual-energy-computed-tomography-analysis-of-cervical-anterior-spinal-artery
#18
Wu Shiyang, Chandoo Suraj, Zhu Minyu, Huang Kelun, Wang Yu, Wang Zhenzhang, Teng Honglin
OBJECTIVE: Cervical myelopathy is a common acquired cause of spinal cord dysfunction in elderly. It is postulated that hypoxic/ischemic environment secondary to chronic spinal cord compression plays an important role in the pathogenesis of myelopathy. This study aims to assess the altered blood flow to spinal cord in Cervical spondylotic myelopthy patients using Dual-Energy Computed Tomography. To our knowledge, this is the first study to utilize DECT in identifying comprised Anterior Spinal Artery blood flow in CSM patients...
April 9, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29643667/role-of-preablative-stimulated-thyroglobulin-in-prediction-of-nodal-and-distant-metastasis-on-iodine-whole-body-scan
#19
Meghana Prabhu, Sanju Samson, Avinash Reddy, Sunil Hejaji Venkataramanarao, Naveen Hedne Chandrasekhar, Vijay Pillai, Vivek Shetty, Moni Abraham Koriokose, Bushan Vaidhya, Subramanian Kannan
Background: Preablative stimulated thyroglobulin (ps-Tg) is an important investigation in the follow-up of patients with Differentiated thyroid cancer(DTC) after surgery. Levels of ps-Tg >2-10 ng/ml have been suggested to predict metastasis to cervical and extracervical sites. There is still debate on the need for routine iodine whole-body scan (131 I WBS) in the management of low-to-intermediate-risk DTC patients. Objective: We analyzed our data of patients with DTC who underwent total thyroidectomy to discuss the predictability of ps-Tg on metastatic disease on the 131 I WBS...
April 2018: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/29643159/role-of-iodine-containing-multivitamins-during-pregnancy-for-children-s-brain-function-protocol-of-an-ongoing-randomised-controlled-trial-the-swiddich-study
#20
Sofia Manousou, Birgitta Johansson, Anna Chmielewska, Janna Eriksson, Kerstin Gutefeldt, Carl-Johan Tornhage, Robert Eggertsen, Helge Malmgren, Lena Hulthen, Magnus Domellöf, Helena Nystrom Filipsson
INTRODUCTION: Iodine is essential for normal brain development. Moderate and severe fetal iodine deficiency results in substantial to serious developmental delay in children. Mild iodine deficiency in pregnancy is associated with neurodevelopmental deficits in the offspring, but evidence from randomised trials is lacking. The aim of the Swedish Iodine in Pregnancy and Development in Children study is to determine the effect of daily supplementation with 150 µg iodine during pregnancy on the offspring's neuropsychological development up to 14 years of age...
April 10, 2018: BMJ Open
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