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The role of iodine

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https://www.readbyqxmd.com/read/28819948/the-role-of-selenium-in-thyroid-gland-pathophysiology
#1
Michał Stuss, Marta Michalska-Kasiczak, Ewa Sewerynek
It is now assumed that proper functioning of the thyroid gland (TG), beside iodine, requires also a number of elements, including selenium, iron, zinc, copper, and calcium. In many cases, only an adequate supply of one of these microelements (e.g. iodine) may reveal symptoms resulting from deficits of other microelements (e.g. iron or selenium). Selenium is accounted to the trace elements of key importance for homeostasis of the human system, in particular, for the proper functioning of the immune system and the TG...
2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/28814251/the-role-of-radiopharmaceuticals-in-amiodarone-induced-thyroid-pathology
#2
Doina Piciu, Alexandru Irimie
Amiodarone is a di-iodinated benzofuran derivative and is classified as a class III antiarrhythmic agent. It is one of the most powerful and effective antiarrhythmics, being a first-line agent due to its ability to treat ventricular and supraventricular dysrhythmias; since 1960 the drug has become one of the most frequently prescribed antiarrhythmics, despite its potentially serious, side effects. By far, one of the most challenging condition is the thyroid pathology induced by this drug. Each 200 mg tablet of amiodarone contains approximately 75 mg of iodine, 3-10% from each tablet being released as free iodine...
August 16, 2017: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/28808810/interactions-of-cisplatin-analogues-with-lysozyme-a-comparative-analysis
#3
Giarita Ferraro, Ilaria De Benedictis, Annamaria Malfitano, Giancarlo Morelli, Ettore Novellino, Daniela Marasco
The biophysical characterization of drug binding to proteins plays a key role in structural biology and in the discovery and optimization of drug discovery processes. The search for optimal combinations of biophysical techniques that can correctly and efficiently identify and quantify binding of metal-based drugs to their final target is challenging, due to the physicochemical properties of these agents. Different cisplatin derivatives have shown different citotoxicities in most common cancer lines, suggesting that they exert their biological activity via different mechanisms of action...
August 14, 2017: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/28800586/the-potential-role-of-kelp-forests-on-iodine-speciation-in-coastal-seawater
#4
Jennifer Gonzales, Teresa Tymon, Frithjof C Küpper, Matthew S Edwards, Carl J Carrano
Kelps have a major role in marine and atmospheric iodine cycling in the coastal zone of temperate regions, with potential wide-ranging impacts on ozone destruction in the coastal marine boundary layer. However, little is known about the impact of kelp forests on iodine speciation in coastal sea water. To address this, we examined iodide and iodate concentrations in seawater in and around a giant kelp forest near San Diego, CA, USA, and a nearby site that was not influenced by kelp biology. Our data shows that while both iodide and iodate concentrations remained unchanged during the year at the nearby site, these concentrations changed significantly in and around the kelp forest, and were strongly related to changes in kelp canopy biomass...
2017: PloS One
https://www.readbyqxmd.com/read/28799338/negative-ion-photoelectron-spectra-of-iso3-is2o3-and-is2o4-intermediates-formed-in-interfacial-reactions-of-ozone-and-iodide-sulfite-aqueous-microdroplets
#5
Zhengbo Qin, Gao-Lei Hou, Zheng Yang, Marat Valiev, Xue-Bin Wang
Three short-lived, anionic intermediates, ISO3(-), IS2O3(-), and IS2O4(-), are detected during reactions between ozone and aqueous iodine/sulfur oxide microdroplets. These species may play an important role in ozone-driven inorganic aerosol formation; however their chemical properties remain largely unknown. This is the issue addressed in this work using negative ion photoelectron spectroscopy (NIPES) and ab initio modeling. The NIPE spectra reveal that all of the three anionic species are characterized by high adiabatic detachment energies (ADEs) - 4...
December 7, 2016: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28782016/light-induced-picosecond-rotational-disordering-of-the-inorganic-sublattice-in-hybrid-perovskites
#6
Xiaoxi Wu, Liang Z Tan, Xiaozhe Shen, Te Hu, Kiyoshi Miyata, M Tuan Trinh, Renkai Li, Ryan Coffee, Shi Liu, David A Egger, Igor Makasyuk, Qiang Zheng, Alan Fry, Joseph S Robinson, Matthew D Smith, Burak Guzelturk, Hemamala I Karunadasa, Xijie Wang, Xiaoyang Zhu, Leeor Kronik, Andrew M Rappe, Aaron M Lindenberg
Femtosecond resolution electron scattering techniques are applied to resolve the first atomic-scale steps following absorption of a photon in the prototypical hybrid perovskite methylammonium lead iodide. Following above-gap photoexcitation, we directly resolve the transfer of energy from hot carriers to the lattice by recording changes in the mean square atomic displacements on 10-ps time scales. Measurements of the time-dependent pair distribution function show an unexpected broadening of the iodine-iodine correlation function while preserving the Pb-I distance...
July 2017: Science Advances
https://www.readbyqxmd.com/read/28770938/the-role-of-halogens-in-on-surface-ullmann-polymerization
#7
Gianluca Galeotti, Marco Di Giovannantonio, Josh Lipton-Duffin, Maryam Ebrahimi, Stefano Tebi, Alberto Verdini, Luca Floreano, Yannick Fagot-Revurat, Dmitrii F Perepichka, Federico Rosei, Giorgio Contini
Ullmann coupling is the most common approach to form surface-confined one- and two-dimensional conjugated structures from haloaryl derivatives. The dimensions of the formed nanostructures can be controlled by the number and location of halogens within the molecular precursors. Our study illustrates that the type of halogen plays an essential role in the design, orientation, and extent of the surface-confined organometallic and polymeric nanostructures. We performed a comparative analysis of five 1,4-dihalobenzene molecules containing chlorine, bromine, and iodine on Cu(110) using scanning tunneling microscopy, fast-X-ray photoelectron and near edge X-ray absorption fine structure spectroscopies...
August 3, 2017: Faraday Discussions
https://www.readbyqxmd.com/read/28770606/experimental-and-theoretical-quantification-of-the-lewis-acidity-of-iodine-iii-species
#8
Axel Labattut, Pierre-Luc Tremblay, Odile Moutounet, Claude Y Legault
The role of hypervalent iodine reagents as oxidants has been widely recognized for more than 20 years. As electrophilic species, they could also play the role of Lewis acids. While not surprising, this aspect of these reagents has not been fully considered and exploited in the literature. The experimental quantification of the Lewis acidity of a small series of diaryliodonium salts was performed using the Gutmann-Beckett method. Validation of a theoretical model using the experimental data was done in order to predict the Lewis acidity of other cationic iodine(III) species...
August 3, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28755858/iodine-is-associated-to-semen-quality-in-men-who-undergo-consultations-for-infertility
#9
Ana B Partal-Lorente, Vicente Maldonado-Ezequiel, Luis Martinez-Navarro, Isidoro Herrera-Contreras, Carolina Gutierrez-Repiso, Eduardo García-Fuentes, Piedad Santiago-Fernandez
The role that adequate iodine intake could have on the male reproductive function is not entirely known. The aim of this study is to determine whether there is a relation between male infertility and urinary and semen iodine levels in 96 couples who underwent consultation for infertility. The median of semen iodine was higher in men who consumed iodized salt than in those who consumed non-iodized salt (p=0.019). Men with a higher semen iodine level had more morphological alterations in spermatozoa (p=0.032)...
July 26, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28746059/nutrition-micronutrients-in-child-growth-and-development-a-systematic-review-on-current-evidence-recommendations-and-opportunities-for-further-research
#10
Mohammad Yawar Yakoob, Clifford W Lo
OBJECTIVE: An important aspect of malnutrition is deficiency of different micronutrients during pregnancy or early childhood. We systematically reviewed the role of nutrition in child growth (weight or height gain) and development. METHODS: A comprehensive literature search was done on PubMed/Cochrane Library browsing through 38,795 abstracts until December 31, 2016 to select systematic reviews/meta-analyses and individual randomized controlled trials (RCTs) of micronutrient supplementation...
July 25, 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/28741707/photophysical-and-photochemical-properties-of-naturally-cccurring-normelinonine-f-and-melinonine-f-alkaloids-and-structurally-related-n-2-and-or-n-9-methyl-%C3%AE-carboline-derivatives
#11
Federico A O Rasse-Suriani, Fernando S García-Einschlag, Matías Rafti, Tobías Schmidt De León, Pedro M David Gara, Rosa Erra-Balsells, Franco M Cabrerizo
In the present work, we have synthesized and fully characterized the photophysical and photochemical properties of a selected group of N-methyl-β-carboline derivatives (9-methyl-β-carbolines and iodine salts of 2-methyl- and 2,9-dimethyl-β-carbolinium) in aqueous solutions, in the pH-range 4.0 - 14.5. Moreover, despite the quite extensive studies reported in the literature regarding the overall photophysical behaviour of N-unsubstituted βCs, this work constitutes the first full and unambiguous characterization of anionic species of N-unsubstituted βCs (norharmane, harmane and harmine), present in aqueous solution under highly alkaline conditions (pH > 13...
July 25, 2017: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/28737011/a-distinctive-patchy-osteomalacia-characterises-phospho1-deficient-mice
#12
Alan Boyde, Katherine A Staines, Behzad Javaheri, Jose Luis Millan, Andrew A Pitsillides, Colin Farquharson
The phosphatase PHOSPHO1 is involved in the initiation of biomineralisation. Bones in Phospho1 knockout (KO) mice show histological osteomalacia with frequent bowing of long bones and spontaneous fractures: they contain less mineral, with smaller mineral crystals. However, the consequences of Phospho1 ablation on the microscale structure of bone are not yet fully elucidated. Tibias and femurs obtained from wild-type and Phospho1 null (KO) mice (25-32 weeks old) were embedded in PMMA, cut and polished to produce near longitudinal sections...
August 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/28724406/iodine-concentration-calculated-by-dual-energy-computed-tomography-dect-as-a-functional-parameter-to-evaluate-thyroid-metabolism-in-patients-with-hyperthyroidism
#13
Duong Duc Binh, Takahito Nakajima, Hidenori Otake, Tetsuya Higuchi, Yoshito Tsushima
BACKGROUND: Thyroid function in patients with Grave's disease is usually evaluated by thyroid scintigraphy with radioactive iodine. Recently, dual-energy computed tomography (DECT) with two different energy X-rays can calculate iodine concentrations and can be applied for iodine measurements in thyroid glands. This study aimed to assess the potential use of DECT for the functional assessment of the thyroid gland. METHODS: Thirteen patients with Grave's disease treated at our hospital from May to September 2015 were included in this retrospective study...
July 19, 2017: BMC Medical Imaging
https://www.readbyqxmd.com/read/28720593/vitamin-a-endocrine-tissues-and-hormones-interplay-and-interactions
#14
Julie Brossaud, Veronique Pallet, Jean-Benoit Corcuff
Vitamin A (retinol) is a micronutrient critical for cell proliferation and differentiation. In adults, vitamin A and metabolites such as retinoic acid (RA) play major roles in vision, immune and brain functions, and tissue remodelling and metabolism. This review presents the physiological interactions of retinoids and endocrine tissues and hormonal systems. Two endocrine systems have been particularly studied. In the pituitary, retinoids targets the corticotrophs with a possible therapeutic use in corticotropinomas...
July 18, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28718179/genetic-alterations-in-pendrin-slc26a4-gene-in-adult-hypothyroid-patients
#15
Sourav Mukherjee, Manalee Guha, Bidisha Adhikary, Biswabandhu Bankura, Pubali Mitra, Subhankar Chowdhury, Madhusudan Das
Current study was aimed to screen the SLC26A4 gene in 127 nonautoimmune and noncongenital hypothyroid patients, who were under optimal iodine nutrition and devoid of any characteristics of Pendred syndrome from eastern part of Indian population. 8 single nucleotide variants/mutations were identified in heterozygous state in 20% patient population, which include 1 novel nonsynonymous (p.C18S), 1 novel intronic (g.942C>A), 3 known nonsynonymous (p.S23X, p.V239D, and p.I455F), and 3 known intronic (g.23034G>T, g...
July 17, 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/28712279/the-role-of-adjuvant-external-beam-radiation-therapy-for-papillary-thyroid-carcinoma-invading-the-trachea
#16
Young Suk Kim, Jae Hyuck Choi, Kwang Sik Kim, Gil Chae Lim, Jeong Hong Kim, Ju Wan Kang, Hee-Sung Song, Sang Ah Lee, Chang Lim Hyun, Yunseon Choi, Gwi Eon Kim
PURPOSE: To evaluate the effect of adjuvant external beam radiation therapy (EBRT) on local failure-free survival rate (LFFS) for papillary thyroid cancer (PTC) invading the trachea. MATERIALS AND METHODS: Fifty-six patients with locally advanced PTC invading the trachea were treated with surgical resection. After surgery, 21 patients received adjuvant EBRT and radioactive iodine therapy (EBRT group) and 35 patients were treated with radioactive iodine therapy (control group)...
June 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/28712072/clinical-role-of-guidance-by-c-arm-ct-for-125-i-brachytherapy-on-pulmonary-tumors
#17
Dechao Jiao, Kewei Ren, Zongming Li, Shaofeng Shui, Xinwei Han
PURPOSE: To evaluate the clinical value of C-arm CT (CACT)-guided interstitial iodine-125 ((125)I) brachytherapy on pulmonary tumors. MATERIALS AND METHODS: 30 patients with 40 solid pulmonary tumors were enrolled to undergo CACT-guided interstitial (125)I brachytherapy between November 2011 and November 2014. The needle path was planned on a CACT virtual navigation and real-time fluoroscopy system. Technical success, puncture score, procedure time, local control rate (LCR), radiation exposure, complications and survival were investigated...
July 15, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28707872/povidone-iodine-based-polymeric-nanoparticles-for-antibacterial-applications
#18
Tianyi Gao, Hongbo Fan, Xinjie Wang, Yangyang Gao, Wenxin Liu, Wanjun Chen, Alideertu Dong, Yan-Jie Wang
As microbial contamination is becoming more and more serious, antibacterial agents play an important role in preventing and removing bacterial pathogens from microbial pollution in our daily life. To solve the issues with water solubility and antibacterial stability of PVP-I2 (povidone-iodine) as a strong antibacterial agent, we successfully obtain hydrophobic povidone-iodine nanoparticles (povidone-iodine NPs) by a two-step method related to the advantage of nanotechnology. First, the synthesis of poly(N-vinyl-2-pyrrolidone-co-methyl methacrylate) nanoparticles, i...
August 9, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28698763/wolf-s-panniculitis
#19
Anastasiya Atanasova Chokoeva, Georgi Tchernev
A 28-year-old male patient, presented with a one-week history of pain and itching on the skin of the left upper leg. Erythematous indurated, warm and painful on palpation, subcutaneous plaques and nodules were clinically observed, affecting the skin of the left upper leg, within a recent black-wolf tattoo. The diagnosis of traumatic panniculitis with superposed bacterial infection, provoked by a wolf tattoo was made. The patient underwent 7-days systemic antibiotic treatment regimen and topical application of iodine povidone unguent under occlusion for 7 days...
June 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28693291/diagnostic-clue-of-nodular-fasciitis-mimicking-metastasis-in-papillary-thyroid-cancer-mismatching-findings-on-18-f-fdg-pet-ct-and-123-i-whole-body-scan-a-case-report
#20
Minjung Seo, Misung Kim, Eun Sook Kim, Hongbo Sim, Sungmin Jun, Seol Hoon Park
This study reports a case of nodular fasciitis incidentally detected in a patient with papillary thyroid cancer. A 47-year-old woman underwent a total thyroidectomy and radioactive iodine therapy for papillary thyroid cancer. On a follow-up fluorodeoxyglucose ((18)F-FDG) PET/computed tomography (CT) scan after 12 months, a focal (18)F-FDG-avid lesion was incidentally detected in the paraspinal muscle. It was well-enhanced on CT and magnetic resonance imaging, indicating metastasis. However, the lesion was not iodine avid on the (123)I whole body scan, which favored benign etiology over metastasis from thyroid cancer...
July 2017: Oncology Letters
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