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The role of iodine

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https://www.readbyqxmd.com/read/28435761/dual-energy-ct-in-head-and-neck-imaging
#1
REVIEW
Elise D Roele, Veronique C M L Timmer, Lauretta A A Vaassen, Anna M J L van Kroonenburgh, A A Postma
PURPOSE OF REVIEW: To explain the technique of Dual-energy CT (DECT) and highlight its applications and advantages in head and neck radiology. RECENT FINDINGS: Using DECT, additional datasets can be created next to conventional images. In head and neck radiology, three material decomposition algorithms can be used for improved lesion detection and delineation of the tumor. Iodine concentration measurements can aid in differentiating malignant from nonmalignant lymph nodes and benign posttreatment changes from tumor recurrence...
2017: Current Radiology Reports
https://www.readbyqxmd.com/read/28428640/transforming-growth-factor-%C3%AE-plays-an-important-role-in-enhancing-wound-healing-by-topical-application-of-povidone-iodine
#2
Li Wang, Wenhan Qin, Yaying Zhou, Bin Chen, Xiaoqing Zhao, Hailin Zhao, Emma Mi, Ella Mi, Qingmei Wang, Jiaolin Ning
Povidone-iodine (PVI) is principally used as an antimicrobial agent. It has been found that 0.5% PVI can attenuate congestion, edema and pain induced by pressure sores. Thus this study aimed to assess the effects of 0.5% PVI on acute skin wounds. Four full-thickness excisional wounds were generated on the dorsal skin of male Sprague-Dawley rats with a 10-mm sterile punch. Two wounds were left untreated and the other two were dressed with gauze with 0.5% PVI for 1 hour per day for the first 5 days after injury...
April 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28417080/applying-a-systems-approach-to-thyroid-physiology-looking-at-the-whole-with-a-mitochondrial-perspective-instead-of-judging-single-tsh-values-or-why-we-should-know-more-about-mitochondria-to-understand-metabolism
#3
REVIEW
Roy Moncayo, Helga Moncayo
Classical thinking in endocrine physiology squeezes our diagnostic handling into a simple negative feedback mechanism with a controller and a controlled variable. In the case of the thyroid this is reduced to TSH and fT3 and fT4, respectively. The setting of this tight notion has no free space for any additions. In this paper we want to challenge this model of limited application by proposing a construct based on a systems approach departing from two basic considerations. In first place since the majority of cases of thyroid disease develop and appear during life it has to be considered as an acquired condition...
June 2017: BBA Clinical
https://www.readbyqxmd.com/read/28413794/comparative-evaluation-of-iodine-131-metaiodobenzylguanidine-and-18-fluorodeoxyglucose-positron-emission-tomography-in-assessing-neural-crest-tumors-will-they-play-a-complementary-role
#4
Soumyakanti Kundu, Purushottam Kand, Sandip Basu
BACKGROUND: 18-Fluorodeoxyglucose positron emission tomography (FDG-PET) has established a role in the evaluation of several malignancies. However, its precise clinical role in the neural crest cell tumors continues to evolve. PURPOSE: The purpose of this study was to compare iodine-131 metaiodobenzylguanidine ((131)I-MIBG) and FDG-PET of head to head in patients with neural crest tumors both qualitatively and semiquantitatively and to determine their clinical utility in disease status evaluation and further management...
January 2017: South Asian Journal of Cancer
https://www.readbyqxmd.com/read/28409443/role-of-prophylactic-central-neck-dissection-in-clinically-node-negative-differentiated-thyroid-cancer-assessment-of-the-risk-of-regional-recurrence
#5
Pietro Giorgio Calò, Celestino Pio Lombardi, Francesco Podda, Luca Sessa, Luigi Santini, Giovanni Conzo
Prophylactic central neck dissection in clinically node-negative patients remains controversial. The aim of this multicenter retrospective study was to determine the rate of metastases in the central neck in clinically node-negative differentiated thyroid cancer patients, to examine the morbidity, and to assess the risk of regional recurrence in patients treated with total thyroidectomy with concomitant bilateral or ipsilateral central neck dissection compared with those undergoing total thyroidectomy alone...
April 13, 2017: Updates in Surgery
https://www.readbyqxmd.com/read/28403606/halogenated-organic-compounds-identified-in-hydraulic-fracturing-wastewaters-using-ultrahigh-resolution-mass-spectrometry
#6
Jenna Lynn Luek, Philippe Schmitt-Kopplin, Paula J Mouser, William Tyler Petty, Susan D Richardson, Michael Gonsior
Large volumes of water return to the surface following hydraulic fracturing of deep shale formations to retrieve oil and natural gas. Current understanding of the specific organic constituents in these hydraulic fracturing wastewaters is limited to hydrocarbons and a fraction of known chemical additives. In this study, we analyzed hydraulic fracturing wastewater samples using ultrahigh resolution Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR-MS) as a non-targeted technique to assign unambiguous molecular formulas to singly charged molecular ions...
April 12, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28396984/iodinated-tg-in-thyroid-follicles-regulate-tsh-tshr-signaling-for-nis-expression
#7
Huibin Huang, Yaxiong Shi, Bo Liang, Huiyao Cai, Qingyan Cai
Our previous research has suggested that high degree of iodinated thyroglobulin (TG) may inhibit the expression and function of sodium iodide symporter (NIS), but the underlying mechanism remains unclear. In present study, we discuss a newly constructed follicle model in vitro, which was used to simulate the follicular structure of the thyroid and explore the regulatory roles of iodinated TG in the follicular lumen on NIS expression. The results showed that both NIS expression and PKA activity were increased in lowly iodinated TG group, while decreased NIS expression with increased PKC activity was found in highly iodinated TG group...
April 10, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28391026/radiopharmaceuticals-in-the-elderly-cancer-patient-practical-considerations-with-a-focus-on-prostate-cancer-therapy-a-position-paper-from-the-international-society-of-geriatric-oncology-task-force
#8
John O Prior, Silke Gillessen, Manfred Wirth, William Dale, Matti Aapro, Wim J G Oyen
Molecular imaging using radiopharmaceuticals has a clear role in visualising the presence and extent of tumour at diagnosis and monitoring response to therapy. Such imaging provides prognostic and predictive information relevant to management, e.g. by quantifying active tumour mass using positron emission tomography/computed tomography (PET/CT). As these techniques require only pharmacologically inactive doses, age and potential frailty are generally not important. However, this may be different for therapy involving radionuclides because the radiation can impact normal bodily function (e...
April 6, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28388674/variation-in-the-mineral-element-concentration-of-moringa-oleifera-lam-and-m-stenopetala-bak-f-cuf-role-in-human-nutrition
#9
Diriba B Kumssa, Edward Jm Joy, Scott D Young, David W Odee, E Louise Ander, Martin R Broadley
BACKGROUND: Moringa oleifera (MO) and M. stenopetala (MS) (family Moringaceae; order Brassicales) are multipurpose tree/shrub species. They thrive under marginal environmental conditions and produce nutritious edible parts. The aim of this study was to determine the mineral composition of different parts of MO and MS growing in their natural environments and their potential role in alleviating human mineral micronutrient deficiencies (MND) in sub-Saharan Africa. METHODS: Edible parts of MO (n = 146) and MS (n = 50), co-occurring cereals/vegetables and soils (n = 95) underneath their canopy were sampled from localities in southern Ethiopia and Kenya...
2017: PloS One
https://www.readbyqxmd.com/read/28388272/anomalous-coronary-arteries-that-need-intervention-review-of-pre-and-postoperative-imaging-appearances
#10
Prachi P Agarwal, Carole Dennie, Elena Pena, Elsie Nguyen, Troy LaBounty, Bo Yang, Smita Patel
Coronary artery anomalies constitute a diverse group of abnormalities, ranging from anatomic variants to those having hemodynamic consequences. This review focuses on major anomalies that have clinical implications requiring treatment, including anomalous origin of the coronary artery from the opposite sinus with interarterial course specifically with an intramural course, coronary artery origin from the pulmonary artery, and coronary artery fistula. Comprehensive imaging evaluation is necessary to precisely delineate the anatomy as well as pathophysiologic aspects of the anomaly before determining treatment options for a specific patient...
April 7, 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28381805/investigation-of-biodistribution-and-speciation-changes-of-orally-administered-dual-radiolabeled-complex-bis-5-chloro-7-131-i-iodo-8-quinolinolato-65-zn-zinc
#11
Masayuki Munekane, Masashi Ueda, Shinji Motomura, Shinichiro Kamino, Hiromitsu Haba, Yutaka Yoshikawa, Hiroyuki Yasui, Shuichi Enomoto
Many zinc (Zn) complexes have been developed as promising oral antidiabetic agents. In vitro assays using adipocytes have demonstrated that the coordination structures of Zn complexes affect the uptake of Zn into cells and have insulinomimetic activities, for which moderate stability of Zn complexes is vital. The complexation of Zn plays a major role improving its bioavailability. However, investigation of the speciation changes of Zn complexes after oral administration is lacking. A dual radiolabeling approach was applied in order to investigate the speciation of bis(5-chloro-7-iodo-8-quinolinolato)zinc complex [Zn(Cq)2], which exhibits the antidiabetic activity in diabetic mice...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28378506/structural-transformation-and-stabilization-of-metal-organic-motifs-induced-by-halogen-doping
#12
Lei Xie, Chi Zhang, Yuanqi Ding, Wei Xu
The structural transformation of supramolecular nanostructures with constitutional diversity and adaptability by dynamic coordination chemistry would be of fundamental importance for potential applications in molecular switching devices. The role of halogen doping in the formation of elementary metal-organic motifs on surfaces has not been reported. Now, the 9-ethylguanine molecule (G) and Ni atom, as a model system, are used for the structural transformation and stabilization of metal-organic motifs induced by iodine doping on Au(111)...
April 5, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28367759/role-of-the-iodine-global-network-in-elimination-of-iodine-deficiency
#13
John H Lazarus
Background Iodine deficiency (ID) is a major cause of brain damage if not corrected in early pregnancy. Even mild ID leads to measurable neurointellectual impairment. The iodine global network (IGN), previously the international council for the control of iodine deficiency disorders (ICCIDD), has achieved remarkable progress in facilitating iodine nutritional sufficiency in about 70-80% of countries in the world during the past 3 decades or so. Results At present there are 25 countries with documented iodine deficiency...
March 30, 2017: Recent Patents on Endocrine, Metabolic & Immune Drug Discovery
https://www.readbyqxmd.com/read/28363255/glycyrrhizin-a-direct-hmgb1-antagonist-ameliorates-inflammatory-infiltration-in-a-model-of-autoimmune-thyroiditis-via-inhibition-of-tlr2-hmgb1-signaling
#14
Chenyan Li, Shiqiao Peng, Xin Liu, Cheng Han, Xinyi Wang, Ting Jin, Shanshan Liu, Weiwei Wang, Xiaochen Xie, Xue He, Hanyi Zhang, Ling Shan, Chenling Fan, Zhongyan Shan, Weiping Teng
Background:High mobility group box-1(HMGB1), a non-histone protein, plays an important role in autoimmune diseases. However, the significance of HMGB1 in the pathogenesis of autoimmune thyroiditis has not been reported. The purpose of this study was to explore whether HMGB1 is participated in the progress of autoimmune thyroiditis and glycyrrhizin(GL), a direct inhibitor of HMGB1, relieves the severity of thyroid inflammatory infiltration in a murine model of autoimmune thyroiditis. METHODS: A total of 80 male NOD...
March 31, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28356096/%C3%AE-cell-protection-and-antidiabetic-activities-of-crassocephalum-crepidioides-asteraceae-benth-s-moore-extract-against-alloxan-induced-oxidative-stress-via-regulation-of-apoptosis-and-reactive-oxygen-species-ros
#15
Entaz Bahar, Kazi-Marjahan Akter, Geum-Hwa Lee, Hwa-Young Lee, Harun-Or Rashid, Min-Kyung Choi, Kashi Raj Bhattarai, Mir Mohammad Monir Hossain, Joushan Ara, Kishor Mazumder, Obayed Raihan, Han-Jung Chae, Hyonok Yoon
BACKGROUND: Medicinal plants are becoming more popular in the treatment of various diseases because of the adverse effects of the current therapy, especially antioxidant plant components such as phenols and flavonoids have a protective role against oxidative stress-induced degenerative diseases like diabetes. Thus, the purpose of this study was to investigate β-cell protection and antidiabetic activities of Crassocephalum crepidioides (Asteraceae) Benth. S. Moore. METHOD: The in-vitro study was conducted by the pancreatic β-cell culture and α-amylase inhibition technique which includes two methods, namely starch-iodine method and 3,5-dinitrosalicylic acid (DNSA) method...
March 29, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28355089/ct-vaginography-a-new-ct-technique-for-imaging-of-upper-and-middle-vaginal-fistulas
#16
Diomidis Botsikas, Nicola Pluchino, Anastasia Kalovidouri, Alexandra Platon, Xavier Montet, Patrick Dallenbach, Pierre-Alexandre Poletti
OBJECTIVE: Different types of vaginal fistulas is a relatively uncommon condition in the Western world but very frequent in developing countries. In the past, conventional vaginography was the radiological examination of choice for exploring this condition. CT and MRI are now both used for this purpose. Our objective was to test the feasibility and to explore the potential role of a new CT imaging technique implementing vaginal introitus obstruction and opacification of the vagina with iodine contrast agent, to show patency of a fistula...
May 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28337546/robotic-thyroidectomy-versus-conventional-open-thyroidectomy-for-thyroid-cancer-a-systematic-review-and-meta-analysis
#17
Jing-Hua Pan, Hong Zhou, Xiao-Xu Zhao, Hui Ding, Li Wei, Li Qin, Yun-Long Pan
BACKGROUND: Despite the new technical alternative offered by the robotic surgery for minimally invasive thyroid surgery, the role of the robotic thyroidectomy (RT) in thyroid cancer has been highly disputed. This paper gives a systematic review and meta-analysis aiming to compare RT and open thyroidectomy (OT) based on the surgical outcomes and oncologic results. METHODS: Relevant literature was searched from various databases up to July 2016, including PubMed, MEDLINE, EMBASE, Cochrane Library, Web of science and Clinical Trials...
March 23, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28333271/impact-of-thyroid-autoimmunity-in-euthyroid-women-on-live-birth-rate-after-iui
#18
D Unuane, B Velkeniers, B Bravenboer, P Drakopoulos, H Tournaye, J Parra, M De Brucker
STUDY QUESTION: Does thyroid autoimmunity (TAI) predict live birth rate in euthyroid women after one treatment cycle in IUI patients? SUMMARY ANSWER: TAI as such does not influence pregnancy outcome after IUI treatment. WHAT IS KNOWN ALREADY: The role of TAI on pregnancy outcome in the case of IVF/ICSI is largely debated in the literature. This is the first study to address this issue in the case of IUI. STUDY DESIGN, SIZE, DURATION: This was a retrospective cohort study...
April 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28323998/genes-outside-the-major-histocompatibility-complex-locus-are-linked-to-the-development-of-thyroid-autoantibodies-and-thyroiditis-in-nod-h2h4-mice
#19
Sandra M McLachlan, Sylvie Lesage, Roxanne Collin, Bianca Banuelos, Holly A Aliesky, Basil Rapoport
Thyroiditis and autoantibodies to thyroglobulin (TgAb) and thyroid peroxidase (TPOAb) develop spontaneously in NOD.H2h4 mice, a phenotype enhanced by dietary iodine. NOD.H2h4 mice were derived by introducing the major histocompatibility class (MHC) molecule I-Ak from B10.A(4R) mice to nonobese diabetic (NOD) mice. Apart from I-Ak, the genes responsible for the NOD.H2h4 phenotype are unknown. Extending serendipitous observations from crossing BALB/c to NOD.H2h4 mice, thyroid autoimmunity was investigated in both genders of the F1, F2, and the second-generation backcross of F1 to NOD...
April 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28322461/iodinated-tg-in-thyroid-follicular-lumen-regulates-ttf-1-and-pax8-expression-via-tsh-tshr-signaling-pathway
#20
Huibin Huang, Yaxiong Shi, Bo Liang, Huiyao Cai, Qingyan Cai
Our previous study showed that highly iodinated thyroglobulin (TG) inhibited thyroid transcription factor-1 (TTF-1) and paired box gene 8 (PAX8) expression, but the potential mechanism remains unclear. In this study, we constructed a thyroid follicle model in vitro to mimic its natural physiological structure and explored how iodinated TG in the follicular lumen tuned TTF-1 and PAX8 expression. Our data showed that lowly iodinated TG enhanced PKA activity while upregulation of both TTF-1 and PAX8 expression; and that highly iodinated TG triggered PKC activity while suppression of TTF-1 and PAX8 expression...
March 21, 2017: Journal of Cellular Biochemistry
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