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RA lag

Jakub Závada, Petra Hánová, Jana Hurňáková, Lenka Szczuková, Michal Uher, Šárka Forejtová, Martin Klein, Herman Mann, Marta Olejárová, Olga Růžičková, Olga Šléglová, Karel Hejduk, Karel Pavelka
BACKGROUND: Restoring normal physical functioning is a major therapeutic aim in the management of rheumatoid arthritis (RA). It is unknown, whether the extent of synovial inflammation quantified by musculoskeletal ultrasound (US) can predict current or future capacity for physical functioning. To answer this question we investigated the longitudinal relationship between physical function assessed by the health assessment questionnaire (HAQ) and the German 7-joint ultrasound score (US7S) in a prospective cohort of patients with RA...
January 13, 2017: Arthritis Research & Therapy
Yang Liu, Hong-Yan Wen, Li-Hua Wang, Chen Wang
INTRODUCTION: The co-existence of focal segmental glomerulosclerosis (FSGS) and rheumatoid arthritis (RA), presenting either together or in succession, is very rare. A variety of histopathological features in the clinical renal disease may occur in RA. Only 8 studies have previously reported this poorly understood connection. CLINICAL FINDINGS/DIAGNOSES: A case of a 54-year-old male with RA lasting for more than 7 years developed cheirarthritis as the first signs...
January 2017: Medicine (Baltimore)
Chae Hun Ra, Min Ji Kim, Gwi-Taek Jeong, Sung-Koo Kim
A total monosaccharide concentration of 37.8 g/L and 85.9% conversion from total fermentable monosaccharides of 44.0 g/L from 110 g dw/L Eucheuma denticulatum slurry were obtained by thermal acid hydrolysis and enzymatic saccharification. Subsequent adsorption treatment to remove 5-hydroxymethylfurfural (5-HMF) using 5% activated carbon and an adsorption time of 10 min were used to prevent a prolonged lag phase, reduced cell growth, and low ethanol production. The equilibrium adsorption capacity (q e) of HMF (58...
November 9, 2016: Bioprocess and Biosystems Engineering
Kevin C Chung, Sandra V Kotsis, Patricia B Burns, Frank D Burke, E F Shaw Wilgis, David A Fox, H Myra Kim
OBJECTIVE: Rheumatoid arthritis (RA) causes destruction of the metacarpophalangeal (MCP) joints leading to hand deformities, pain, and loss of function. This study prospectively assessed long-term functional and health-related quality of life outcomes in RA patients with severe deformity at the MCP joints. METHODS: RA patients between the ages of 18-80 with severe deformity at the MCP joints were referred to one of the three study sites. Subjects who elected to undergo silicone metacarpophalangeal joint arthroplasty (SMPA) while continuing with medical management were followed in the SMPA cohort...
October 1, 2016: Arthritis Care & Research
Dam Kim, Chan-Bum Choi, Jiyoung Lee, Soo-Kyung Cho, Soyoung Won, So-Young Bang, Hoon-Suk Cha, Jung-Yoon Choe, Won Tae Chung, Seung-Jae Hong, Jae-Bum Jun, Young Ok Jung, Jinseok Kim, Seong-Kyu Kim, Tae-Hwan Kim, Tae-Jong Kim, Eunmi Koh, Hye-Soon Lee, Jaejoon Lee, Jisoo Lee, Sang-Heon Lee, Shin-Seok Lee, Sung Won Lee, Seung-Cheol Shim, Dae-Hyun Yoo, Bo Young Yoon, Yoon-Kyoung Sung, Sang-Cheol Bae
Background/Aims: To determine whether early diagnosis is beneficial for functional status of various disease durations in rheumatoid arthritis (RA) patients. Methods: A total of 4,540 RA patients were enrolled as part of the Korean Observational Study Network for Arthritis (KORONA). We defined early diagnosis as a lag time between symptom onset and RA diagnosis of ≤ 12 months, whereas patients with a longer lag time comprised the delayed diagnosis group. Demographic characteristics and outcomes were compared between early and delayed diagnosis groups...
September 13, 2016: Korean Journal of Internal Medicine
Laura Solfietti, Giovanni B Binello, Stefania Stella, Mario Bazzan, Milena Salierno, Dario Roccatello
OBJECTIVES: Growing evidences show a direct link between inflammation and activation of haemostasis. That could increase thrombotic and cardiovascular risk in patients with active autoimmune diseases such as rheumatoid arthritis (RA) and systemic sclerosis (SSc). The aim of this study was to evaluate a possible hypercoagulable condition in RA and SSc patients, using the thrombin generation assay (TGA). METHODS: TGA was assessed in 44 RA [33 with active disease (actRA) and 11 inactive (non-actRA)], 25 SSc patients and 41 healthy controls using a fluorimetric technique and the TGA RB Low reagent...
September 2016: Clinical and Experimental Rheumatology
Daniel Daigle, Agnès Costerg, Anne Plisson, Noémia Ruberto, Joëlle Varin
For children with dyslexia, learning to write constitutes a great challenge. There has been consensus that the explanation for these learners' delay is related to a phonological deficit. Results from studies designed to describe dyslexic children's spelling errors are not always as clear concerning the role of phonological processes as those found in reading studies. In irregular languages like French, spelling abilities involve other processes than phonological processes. The main goal of this study was to describe the relative contribution of these other processes in dyslexic children's spelling ability...
May 2016: Dyslexia: the Journal of the British Dyslexia Association
B Charruau, J Laulan, Y Saint-Cast
BACKGROUND: Swan-neck deformity (SND) of the fingers can cause major functional impairment. The Zancolli-Tonkin procedure is a crossed dynamic tenodesis that prevents overextension of the proximal interphalangeal (PIP) joint and promotes extension of the distal interphalangeal (DIP) joint. We assessed the outcomes of this procedure in patients with SND due to various causes. HYPOTHESIS: The Zancolli-Tonkin procedure provides effective and stable correction of SND due not only to RA, but also to other conditions...
June 2016: Orthopaedics & Traumatology, Surgery & Research: OTSR
Roisin S M Hegarty, Gareth J Treharne, Simon Stebbings, Tamlin S Conner
OBJECTIVE: The present study examined the within-day relationship between fatigue and positive and negative mood among adults with rheumatoid arthritis (RA) or osteoarthritis (OA). METHOD: A sample of 142 adults-70 with RA and 72 with OA (67.6% women, 32.4% men)-completed daily diaries during 4 fixed time windows per day for 7 days. In each diary, participants reported fatigue, pain, happiness, and frustration. Multilevel modeling tested the temporal patterns in fatigue across the day and the lagged associations between fatigue and subsequent mood (and vice versa)...
May 2016: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
Waleed Hussain, Abdulsalam Noorwali, Nahid Janoudi, Maatouqa Baamer, Lina Kebbi, Hanady Mansafi, Ashraf Ibrahim, Shereen Gohary, Joan Minguet, Hani Almoallim
OBJECTIVES: Rheumatoid arthritis (RA) is often not diagnosed or treated quickly enough to alter outcomes. We aimed to evaluate the lag times from disease onset to first clinical consultation and diagnosis and to identify factors contributing to delayed diagnosis in Saudi Arabia. METHODS: This retrospective, multicenter study collected data on 250 patients, from six hospitals in Saudi Arabia, who met the 2010 American College of Rheumatology criteria for RA. RESULTS: The patients mean age was 43...
January 2016: Oman Medical Journal
Noriko Kimura, Katsuya Suzuki, Tsutomu Takeuchi
OBJECTIVES: To evaluate the efficacy and safety of adalimumab (ADA) and methotrexate (MTX) in patients with rheumatoid arthritis (RA) and investigate critical factors associated with efficacy. METHODS: In this retrospective cohort study, patients received ADA at a single facility. Clinical outcome was retrospectively evaluated using the Disease Activity Score in 28 joints with Erythrocyte Sedimentation Rate (DAS28-ESR). RESULTS: Of the 122 patients undergoing treatment with ADA between July 2008 and April 2014, DAS28-ESR data after 6 months of treatment were available for 103 and 87 (84...
September 2016: Modern Rheumatology
Kechi Fang, Kunlin Zhang, Jing Wang
Primary Sjögren's syndrome (pSS) is a complex autoimmune disorder. So far, genetic research in pSS has lagged far behind and the underlying biological mechanism is unclear. Further exploring existing genome-wide association study (GWAS) data is urgently expected to uncover disease-related gene combination patterns. Herein, we conducted a network-based analysis by integrating pSS GWAS in Han Chinese with a protein-protein interactions network to identify pSS candidate genes. After module detection and evaluation, 8 dense modules covering 40 genes were obtained for further functional annotation...
December 21, 2015: Scientific Reports
Anastasios Papapetrou, Demetrios Moris, Nikolaos Patelis, George N Kouvelos, Chris Bakogiannis, Chris Klonaris, Sotiris Georgopoulos
BACKGROUND The exact role of shunting during carotid endarterectomy remains controversial and unclear. The aim of this experimental study was to investigate to what degree carotid clamping may induce changes in the cerebral oxidative status and to focus on the relation of these changes with shunt insertion. MATERIAL AND METHODS Forty New-Zealand rabbits were randomized into 4 groups: group 1 classifying animals with carotid shunt and patent contralateral carotid artery; group 2 shunt and occlusion of the contralateral carotid artery; group 3 no-shunt and patent contralateral carotid artery; and group 4 no-shunt and occlusion of the contralateral carotid artery...
2015: Medical Science Monitor Basic Research
Yvonne C Lee, Jessica Agnew-Blais, Susan Malspeis, Katherine Keyes, Karen Costenbader, Laura D Kubzansky, Andrea L Roberts, Karestan C Koenen, Elizabeth W Karlson
OBJECTIVE: To examine the association between symptoms of post-traumatic stress disorder (PTSD) and rheumatoid arthritis (RA) risk in a prospective cohort and to characterize the role of smoking in this relationship. METHODS: A subset (n = 54,224) of the Nurses' Health Study II, a prospective cohort of female nurses, completed the Brief Trauma Questionnaire and a screen for PTSD symptoms. Participants were categorized based on trauma exposure and number of PTSD symptoms...
March 2016: Arthritis Care & Research
Anita Kern, Attila Balog, Sonja Dulic, Eszter Barabás, Mária Kiszelák, Barna Vásárhelyi
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disorder resulting in the erosion of the cartilage and bone. Systemic involvement including the cardiovascular system with the risk of atherosclerosis may also occur. Calibrated automated thrombogram (CAT), a commercially available thrombin generation assay is suitable for the general assessment of the functionality of coagulation system. In this study we performed CAT assay in RA patients and in non-affected control subjects (matched for age, sex and comorbidities)...
April 2016: Journal of Thrombosis and Thrombolysis
I Hollan, P H Dessein, N Ronda, M C Wasko, E Svenungsson, S Agewall, J W Cohen-Tervaert, K Maki-Petaja, M Grundtvig, G A Karpouzas, P L Meroni
The increased risk of cardiovascular disease (CVD) in rheumatoid arthritis (RA) has been recognized for many years. However, although the characteristics of CVD and its burden resemble those in diabetes, the focus on cardiovascular (CV) prevention in RA has lagged behind, both in the clinical and research settings. Similar to diabetes, the clinical picture of CVD in RA may be atypical, even asymptomatic. Therefore, a proactive screening for subclinical CVD in RA is warranted. Because of the lack of clinical trials, the ideal CVD prevention (CVP) in RA has not yet been defined...
October 2015: Autoimmunity Reviews
Emily Molina, Inmaculada Del Rincon, Jose Felix Restrepo, Daniel F Battafarano, Agustin Escalante
OBJECTIVE: To examine the association of socioeconomic status (SES) and delays in disease-modifying antirheumatic drug (DMARD) treatment with clinical measures in rheumatoid arthritis (RA) patients. METHODS: RA patients were recruited from rheumatology practices. We assessed SES based on education, occupation, and income, and divided patients into tertiles. The time from RA symptom onset to DMARD initiation (DMARD lag) was determined by self-report of the 2 dates, and distance to the rheumatologist (Distance) was obtained from Google Maps...
July 2015: Arthritis Care & Research
Tim Spelman, Orla Gray, Maria Trojano, Thor Petersen, Guillermo Izquierdo, Alessandra Lugaresi, Raymond Hupperts, Roberto Bergamaschi, Pierre Duquette, Pierre Grammond, Giorgio Giuliani, Cavit Boz, Freek Verheul, Celia Oreja-Guevara, Michael Barnett, Francois Grand'Maison, Maria Edite Rio, Jeannette Lechner-Scott, Vincent Van Pesch, Ricardo Fernandez Bolanos, Shlomo Flechter, Leontien Den Braber-Moerland, Gerardo Iuliano, Maria Pia Amato, Mark Slee, Edgardo Cristiano, Maria Laura Saladino, Mark Paine, Norbert Vella, Krisztian Kasa, Norma Deri, Joseph Herbert, Fraser Moore, Tatjana Petkovska-Boskova, Raed Alroughani, Aldo Savino, Cameron Shaw, Steve Vucic, Vetere Santiago, Elizabeth Alejandra Bacile, Eli Skromne, Dieter Poehlau, Jose Antonio Cabrera-Gomez, Robyn Lucas, Helmut Butzkueven
OBJECTIVE: Previous studies assessing seasonal variation of relapse onset in multiple sclerosis have had conflicting results. Small relapse numbers, differing diagnostic criteria, and single region studies limit the generalizability of prior results. The aim of this study was to determine whether there is a temporal variation in onset of relapses in both hemispheres and to determine whether seasonal peak relapse probability varies with latitude. METHODS: The international MSBase Registry was utilized to analyze seasonal relapse onset distribution by hemisphere and latitudinal location...
December 2014: Annals of Neurology
Maria Jesús Cánepa, Nicolás Matías Ortega, Melisa Carolina Monteleone, Nicolas Mucci, German Gustavo Kaiser, Marcela Brocco, Adrián Mutto
Reproductive biotechnologies such as in vitro fertilization (IVF) and somatic cell nuclear transfer (SCNT) enable improved reproductive efficiency of animals. However, the birth rate of in vitro-derived embryos still lags behind that of their in vivo counterparts. Thus, it is critical to develop an accurate evaluation and prediction system of embryo competence, both for commercial purposes and for scientific research. Previous works have demonstrated that in vitro culture systems induce alterations in the relative abundance (RA) of diverse transcripts and thus compromise embryo quality...
2014: PloS One
Elena Zavyalova, Nadezhda Samoylenkova, Alexander Revishchin, Andrey Golovin, Galina Pavlova, Alexey Kopylov
Aptamers are nucleic acid based molecular recognition elements with a high potential for the theranostics. Some of the aptamers are under development for therapeutic applications as promising antithrombotic agents; and G-quadruplex DNA aptamers, which directly inhibit the thrombin activity, are among them. RA-36, the 31-meric DNA aptamer, consists of two thrombin binding pharmacophores joined with the thymine linker. It has been shown earlier that RA-36 directly inhibits thrombin in the reaction of fibrinogen hydrolysis, and also it inhibits plasma and blood coagulation...
2014: PloS One
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