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https://www.readbyqxmd.com/read/28549738/direct-actions-of-macronutrient-components-on-goldfish-hepatopancreas-in-vitro-to-modulate-the-expression-of-ghr-i-ghr-ii-igf-i-and-igf-ii-mrnas
#1
Juan Ignacio Bertucci, Ayelén Melisa Blanco, Luis Fabián Canosa, Suraj Unniappan
In mammals and fish, somatic growth and metabolism are coordinated by the GH-IGF axis, composed of growth hormone (GH), growth hormone receptors I and II (GHR-I and GHR-II), and the insulin-like growth factors I and II (IGF-I and IGF-II). In order to determine if dietary macronutrients regulate the hepatopancreatic expression of ghr-I, ghr-II, igf-I and igf-II independently of circulating GH, organ culture experiments were conducted. Briefly, goldfish hepatopancreas sections were incubated with different doses of glucose; L-tryptophan; oleic acid; linolenic acid (LNA); eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)...
May 23, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28548560/microalgal-oil-from-schizochytrium-sp-prevents-hfd-induced-abdominal-fat-accumulation-in-mice
#2
Jinhui Yu, Yong Ma, Jie Sun, Liyuan Ran, Youwei Li, Ning Wang, Tao Yu, Wenting Gao, Wenbin Jia, Rujiao Jiang, Meihua Guo, Yuping Bi, Yingjie Wu
OBJECTIVE: Dietary n-3 polyunsaturated fatty acids (PUFAs), especially eicosapentaenoic acids (EPA) and docosahexaenoic acid (DHA), are proved to be effective in obesity reduction. Microalgal oil (MO) is an important alternative source of n-3 PUFAs that effectively alleviates obesity. The aim of the present study was to explore the anti-obesity effects of microalgal oil from Schizochytrium sp. (SMO) and to compare the effects of 2 SMOs (SMO1 and SMO2) with different levels of purity of n-3 PUFAs on high fat diet (HFD)-induced obesity in male C57BL/6J mice...
May 26, 2017: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/28544702/within-person-reproducibility-and-sensitivity-to-dietary-change-of-c15-0-and-c17-0-levels-in-dried-blood-spots-data-from-the-european-food4me-study
#3
Viviana Albani, Carlos Celis-Morales, Clare B O'Donovan, Marianne C Walsh, Clara Woolhead, Hannah Forster, Rosalind Fallaize, Anna L Macready, Cyril F M Marsaux, Santiago Navas-Carretero, Rodrigo San-Cristobal, Silvia Kolossa, Christina Mavrogianni, Christina P Lambrinou, George Moschonis, Magdalena Godlewska, Agnieszka Surwillo, Iwona Traczyk, Thomas E Gundersen, Christian A Drevon, Hannelore Daniel, Yannis Manios, J Alfredo Martinez, Wim H M Saris, Julie A Lovegrove, Michael J Gibney, Eileen R Gibney, John C Mathers, Ashley J Adamson, Lorraine Brennan
SCOPE: Previous work highlighted the potential of odd-chain length saturated fatty acids as potential markers of dairy intake. The aim of this study was to assess the reproducibility of these biomarkers and their sensitivity to changes in dairy intake. METHODS AND RESULTS: Fatty acid profiles and dietary intakes from food frequency questionnaires (FFQs) were measured three times over six months in the Food4Me Study. Reproducibility was explored through intra-class correlation coefficients (ICCs) and within-subject coefficients of variation (WCV)...
May 24, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28542308/lipid-content-and-fatty-acid-composition-of-porosira-glacialis-and-attheya-longicornis-in-response-to-carbon-dioxide-co2-aeration
#4
E Y Artamonova, T Vasskog, H C Eilertsen
In the current study two novel psychrophilic diatoms Porosira glacialis and Attheya longicornis were tested for suitability to CO2 mitigation coupled with production of the physiologically requisite omega- 3 fatty acids. This study is in line with the worldwide conducted research aimed at applying biorefinery concept to heavy polluting industries. Since the production of algal high value compounds, i.e. essential fatty acids, relies on utilization of residual CO2 emissions coming from industry, the costs of such production maybe substantially reduced...
2017: PloS One
https://www.readbyqxmd.com/read/28540852/association-of-polyunsaturated-saturated-fatty-acids-to-metabolic-syndrome-cardiovascular-risk-factors-and-lipoprotein-a-in-hypertensive-type-2-diabetic-patients
#5
Amira Fatma Bennacer, Elmahdi Haffaf, Ghouti Kacimi, Brahim Oudjit, Elhadj-Ahmed Koceir
The interactions between fatty acids (FA) classes: polyunsaturated (PUFA-ω6, PUFA-ω3), saturated (SFA), EPA (eicosapentaenoic acid-ω3), DHA (docosahexaenoic-ω3) and cardiometabolic syndrome (CMS) clusters, thrombosis development and vascular inflammation are subtle. This relationship is mediated by insulin resistance (IR), endothelial dysfunction, platelet aggregation disorder and atherosclerosis. OBJECTIVES: We investigated whether PUFA/SFA - PUFA-ω6/PUFA-ω3 ratios and EPA + DHA can be associated with predictive atherothrombogenic biomarkers status in type 2 diabetes (T2D) patients with or without hypertension (HT)...
June 1, 2017: Annales de Biologie Clinique
https://www.readbyqxmd.com/read/28536068/polyunsaturated-fatty-acids-and-inflammatory-markers-in-major-depressive-episodes-during-pregnancy
#6
Jane Pei-Chen Chang, Chih-Ying Lin, Pan-Yen Lin, Yin-Hua Shih, Tsan-Hung Chiu, Ming Ho, Hui-Ting Yang, Shih-Yih Huang, Piotr Gałecki, Kuan-Pin Su
INTRODUCTION: Prenatal depression (PND) is a common psychiatric disorder in pregnant women and leads to psychosocial dysfunction, high suicidal rate, and adverse childcare. Patients with PND have omega-3 polyunsaturated fatty acid (omega-3 or n-3 PUFAs) deficits, which might link to chronic low-grade inflammatory process and the pathophysiological mechanisms of depression. In this case-control study, we examined the levels of PUFAs and inflammatory cytokines in PND. METHOD: Blood samples were obtained and analyzed from 16 healthy controls and 17 depressed cases (PND group) diagnosed with Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV)...
May 20, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28535834/the-potential-impact-of-compositional-changes-in-farmed-fish-on-its-health-giving-properties-is-it-time-to-reconsider-current-dietary-recommendations
#7
Baukje de Roos, Alan A Sneddon, Matthew Sprague, Graham W Horgan, Ingeborg A Brouwer
Assessment of national dietary guidelines in a number of European countries reveals that some are based on cohort studies, focusing on total seafood consumption, while others are based on the content of EPA and DHA, distinguishing between oily and other fish. The mean actual intake of fish in most countries is around or below the recommended intake, with differences in intake of fish being present between sex and age groups. Many people do not reach the national recommendation for total fish intake. Dietary recommendations for fish and EPA/DHA are based mainly on data collected more than 10 years ago...
May 24, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28534446/blood-fatty-acid-changes-in-healthy-young-americans-in-response-to-a-10-week-diet-that-increased-n-3-and-reduced-n-6-fatty-acid-consumption-a-randomised-controlled-trial
#8
Andrew J Young, Bernadette P Marriott, Catherine M Champagne, Michael R Hawes, Scott J Montain, Neil M Johannsen, Kevin Berry, Joseph R Hibbeln
Military personnel generally under-consume n-3 fatty acids and overconsume n-6 fatty acids. In a placebo-controlled, double-blinded study, we investigated whether a diet suitable for implementation in military dining facilities and civilian cafeterias could benefit n-3/n-6 fatty acid status of consumers. Three volunteer groups were provided different diets for 10 weeks. Control (CON) participants consumed meals from the US Military's Standard Garrison Dining Facility Menu. Experimental, moderate (EXP-Mod) and experimental-high (EXP-High) participants consumed the same meals, but high n-6 fatty acid and low n-3 fatty acid containing chicken, egg, oils and food ingredients were replaced with products having less n-6 fatty acids and more n-3 fatty acids...
May 23, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28530595/comparison-of-solvents-for-extraction-of-krill-oil-from-krill-meal-lipid-yield-phospholipids-content-fatty-acids-composition-and-minor-components
#9
Dan Xie, Jun Jin, Jiang Sun, Li Liang, Xiaosan Wang, Wei Zhang, Xingguo Wang, Qingzhe Jin
The effects of seven different extraction solvents (ethanol, isopropanol, acetone, ethyl acetate, isohexane, n-hexane, and subcritical butane) on the lipid yield and quality of the oil extracted from krill meal were investigated in this study. Phospholipids (PL), fatty acids (FA) composition and minor components including sterols, astaxanthin, vitamin A and tocopherols in the extracted krill oil were analyzed. The results indicated that ethanol and isopropanol led to comparatively higher lipid yields (16.33 and 14...
October 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28529072/rescue-of-il-1%C3%AE-induced-reduction-of-human-neurogenesis-by-omega-3-fatty-acids-and-antidepressants
#10
Alessandra Borsini, Silvia Alboni, Mark A Horowitz, Luis M Tojo, Giuseppe Cannazza, Kuan-Pin Su, Carmine M Pariante, Patricia A Zunszain
Both increased inflammation and reduced neurogenesis have been associated with the pathophysiology of major depression. We have previously described how interleukin-1 (IL-1) β,a pro-inflammatory cytokine increased in depressed patients, decreases neurogenesis in human hippocampal progenitor cells. Here, using the same human in vitro model, we show how omega-3 (ω-3) polyunsaturated fatty acids and conventional antidepressants reverse this reduction in neurogenesis, while differentially affecting the kynurenine pathway...
May 18, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28528591/conversion-ratios-of-n-3-fatty-acids-between-plasma-and-erythrocytes-a-systematic-review-and-meta-regression
#11
Xue Feng Hu, Simran K Sandhu, William S Harris, Hing Man Chan
As biomarkers of dietary intake or disease risk factor, n-3 fatty acid (FA) can be measured in plasma phospholipids (PL), total lipids (TL) or erythrocytes. However, the numeric relationships between n-3 FA in these lipid pools are not clear. Our goal was to derive conversion ratios for plasma and erythrocyte n-3 FA. Potential studies were identified through systematic literature search in PubMed, Embase and the Cochrane Library of Systematic reviews (1950 to October 2014). In all, fifty-six studies reporting n-3 in healthy individuals were included, of which thirty-four articles reported plasma PL and erythrocytes, and twenty-two reported plasma TL and erythrocytes...
May 22, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28527220/quantitative-erythrocyte-omega-3-epa-plus-dha-levels-are-related-to-higher-regional-cerebral-blood-flow-on-brain-spect
#12
Daniel G Amen, William S Harris, Parris M Kidd, Somayeh Meysami, Cyrus A Raji
BACKGROUND: The interrelationships between omega-3 fatty acids status, brain perfusion, and cognition are not well understood. OBJECTIVE: To evaluate if SPECT brain imaging of cerebral perfusion and cognition varies as a function of omega-3 fatty acid levels. METHODS: A random sample of 166 study participants was drawn from a psychiatric referral clinical for which erythrocyte quantification of omega-3 eicosapentaenoic acid (EPA) plus docosahexaenoic acid (DHA) (the Omega-3 Index) was available...
May 18, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28526351/docosahexaenoyl-serotonin-emerges-as-most-potent-inhibitor-of-il-17-and-ccl-20-released-by-blood-mononuclear-cells-from-a-series-of-n-acyl-serotonins-identified-in-human-intestinal-tissue
#13
Ya Wang, Michiel G J Balvers, Henk F J Hendriks, Tessa Wilpshaar, Tjarda van Heek, Renger F Witkamp, Jocelijn Meijerink
Fatty acid amides (FAAs), conjugates of fatty acids with ethanolamine, mono-amine neurotransmitters or amino acids are a class of molecules that display diverse functional roles in different cells and tissues. Recently we reported that one of the serotonin-fatty acid conjugates, docosahexaenoyl serotonin (DHA-5-HT), previously found in gut tissue of mouse and pig, attenuates the IL-23-IL-17 signaling axis in LPS-stimulated mice macrophages. However, its presence and effects in humans remained to be elucidated...
May 16, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28526084/liver-phospholipids-fatty-acids-composition-in-response-to-different-types-of-diets-in-rats-of-both-sexes
#14
Slavica Ranković, Tamara Popović, Jasmina Debeljak Martačić, Snježana Petrović, Mirko Tomić, Đurđica Ignjatović, Gordana Tovilović-Kovačević, Maria Glibetić
BACKGROUND: Dietary intake influence changes in fatty acids (FA) profiles in liver which plays a central role in fatty acid metabolism, triacylglycerol synthesis and energy homeostasis. We investigated the effects of 4-weeks treatment with milk- and fish-based diet, on plasma biochemical parameters and FA composition of liver phospholipids (PL) in rats of both sexes. METHODS: Adult, 4 months old, Wistar rats of both sexes, were fed with different types of diets: standard, milk-based and fish-based, during 4 weeks...
May 19, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28515020/supplementation-with-high-dose-docosahexaenoic-acid-increases-the-omega-3-index-more-than-high-dose-eicosapentaenoic-acid
#15
Janie Allaire, William S Harris, Cécile Vors, Amélie Charest, Johanne Marin, Kristina Harris Jackson, André Tchernof, Patrick Couture, Benoît Lamarche
BACKGROUND: Recent studies suggest that eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids have distinct effects on cardiometabolic risk factors. The Omega-3 Index (O3I), which is calculated as the proportion of EPA and DHA in red blood cell (RBC) membranes, has been inversely associated with the risk of coronary heart diseases and coronary mortality. The objective of this study was to compare the effects of EPA and DHA supplementation on the O3I in men and women with abdominal obesity and subclinical inflammation...
May 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/28511049/the-omega-3-index-and-relative-risk-for-coronary-heart-disease-mortality-estimation-from-10-cohort-studies
#16
William S Harris, Liana Del Gobbo, Nathan L Tintle
BACKGROUND AND AIMS: A recent 19-cohort meta-analysis examined the relationships between biomarkers of omega-3 fatty acids and risk for coronary heart disease (CHD). That study did not, however, report hazard ratios (HRs) specifically as a function of erythrocyte eicosapentaenoic (EPA) plus docosahexaenoic (DHA) levels, a metric called the Omega-3 Index in which EPA + DHA content is expressed as a percent of total fatty acids. The Omega-3 Index has been used in several recent studies and is a validated biomarker of omega-3 fatty acid tissue levels, but additional data are needed to confirm (or refute) the originally-proposed clinical cut-points of <4% (higher risk) and 8%-12% (lower risk)...
May 6, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28503432/nutrient-patterns-and-risk-of-cataract-a-case-control-study
#17
Fatemeh Sedaghat, Matin Ghanavati, Parisa Nezhad Hajian, Sara Hajishirazi, Mehdi Ehteshami, Bahram Rashidkhani
AIM: To assess the relation between nutrient patterns and cataract risk. METHODS: This is a hospital-based case-control study with 97 cataract patients and 198 matched controls. Dietary consumption was collected through a valid food frequency questionnaire (FFQ). Nutrient patterns were detected by applying factor analysis. Unconditional logistic regression models were used to estimate odds ratio (ORs) and 95%CIs. RESULTS: We extracted 5 main nutrient patterns...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28502496/minimal-food-effect-for-eicosapentaenoic-acid-and-docosahexaenoic-acid-bioavailability-from-omega-3-acid-ethyl-esters-with-an-advanced-lipid-technologies-tm-alt-%C3%A2-based-formulation
#18
Miguel A Lopez-Toledano, Thorsteinn Thorsteinsson, Ahmed A Daak, Kevin C Maki, Colleen Johns, Adrian L Rabinowicz, Frederick D Sancilio
BACKGROUND: The absorption of eicosapentaenoic acid (EPA; 20:5n-3) and docosahexaenoic acid (DHA; 22:6n-3) omega-3-acid ethyl esters (EEs) is influenced by food. There is a need for a formulation of EE that is less impacted by food effect. SC401 is a novel Advanced Lipid Technologies-based formulation of EPA-EE and DHA-EE. In the presence of an aqueous medium, Advanced Lipid Technologies forms stable micelles in situ independent of bile salt secretion. This effect is hypothesized to improve EPA-EE and DHA-EE bioavailability while it helps mitigate the food effect associated with their consumption...
March 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28497479/proximate-composition-amino-acid-and-fatty-acid-profiles-of-marine-snail-rapana-venosa-meat-visceral-mass-and-operculum
#19
Fenglei Luo, Ronge Xing, Xueqin Wang, Quancai Peng, Pengcheng Li
BACKGROUND: Rapana venosa (Rv), an important marine snail, presents increasing nutritional, and economic importance. However, there still has been limited information on their nutritional composition. This study highlighted and provided new information on the proximate composition, amino acids and fatty acids profiles of Rv different body parts in order to its better application and research. RESULTS: The operculum contained high amount of protein and flavor amino acids...
May 12, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28495596/the-role-of-omega-3-and-omega-9-fatty-acids-for-the-treatment-of-neuropathic-pain-after-neurotrauma
#20
REVIEW
Iriana Galán-Arriero, Diego Serrano-Muñoz, Julio Gómez-Soriano, Carlos Goicoechea, Julian Taylor, Ana Velasco, Gerardo Ávila-Martín
Omega-3 polyunsaturated fatty acids (PUFAs), such as Docosaexaenoic Acid (DHA) and Eicosapentaenoic Acid (EPA), mediate neuroactive effects in experimental models of traumatic peripheral nerve and spinal cord injury. Cellular mechanisms of PUFAs include reduced neuroinflammation and oxidative stress, enhanced neurotrophic support, and activation of cell survival pathways. Bioactive omega-9 monounsaturated fatty acids, such as Oleic Acid (OA) and 2-Hydroxy Oleic Acid (2-OHOA), also show therapeutic effects in neurotrauma models...
May 8, 2017: Biochimica et Biophysica Acta
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