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Kristine Pettersen, Vivi Talstad Monsen, Caroline Hild Hakvåg Pettersen, Hilde Bremseth Overland, Grete Pettersen, Helle Samdal, Almaz Nigatu Tesfahun, Anne Gøril Lundemo, Geir Bjørkøy, Svanhild A Schønberg
Polyunsaturated fatty acids (PUFAs) are important constituents of the diet and health benefits of omega-3/n-3 PUFAs, especially eicosapentaenoic acid (EPA, 20:5 n-3) and docosahexaenoic acid (DHA, 22:6 n-3) have been well documented in relation to several diseases. Increasing evidence suggests that n-3 PUFAs may have anticancer activity and improve the effect of conventional cancer therapy. The mechanisms behind these effects are still unclear and need to be elucidated. We have examined the DHA-induced stress response in two human colon cancer cell lines, SW620 and Caco-2...
January 2016: Free Radical Biology & Medicine
Divya Thomas, Zafna Rasheed, Jesny Siri Jagan, Krishnapillai Girish Kumar
Electrochemical behavior of artificial antioxidant, butylated hydroxyanisole (BHA), was investigated at a glassy carbon electrode modified with poly L- cysteine [poly (L- Cys/GCE)]. BHA exhibits a pair of well - defined redox peak on L- cysteine modified GCE with Epa = 69 mV and Epc = 4 mV. The modified electrode showed good electrocatalytic activity towards the oxidation of BHA under optimal conditions and exhibited a linear response in the range from 1.0 × 10(-5) to 1.0 × 10(-6) M with a correlation coefficient of 0...
October 2015: Journal of Food Science and Technology
Srinivasan Babuskin, Kesavan Radhakrishnan, Packirisamy Azhagu Saravana Babu, Muthusamy Sukumar, Mohammed Abbas Fayidh, Kalleary Sabina, Ganesan Archana, Meenakshisundaram Sivarajan
The present study evaluates the oxidative stability in chikkis enriched with omega 3 fatty acids using natural antioxidant from Rosmarinus officinalis. The best condition for the extraction of phenolic compounds from Rosmarinus officinalis L. (rosemary) was established, and the antioxidant activity was demonstrated based on inhibition of DPPH free radical formation. Nannochloropsis oculata and Isochrysis galbana are rich sources of Eicosapentanoic acid (EPA) and Docosahexaenoic acid (DHA). Biomass of these microalgae were incorporated in chikkis as omega 3 fatty acid source...
June 2015: Journal of Food Science and Technology
P S Sagar, U N Das
The effect of n-3 and n-6 fatty acids (FAs) on the growth of human cervical carcinoma (HeLa) cells was studied. Of all the FAs tested, docosahexaenoic acid (DHA, 22:6 n-3) and eicosapentaenoic acid (EPA, 20:5 n-3) were found to be the most potent in their cytotoxic action on HeLa cells and the potency of various fatty acids with regard to their cytotoxic action was as follows: DHA > EPA > dihomo-gamma-linolenic acid (DGLA) = gamma-linolenic acid (GLA) > linoleic acid (LA) > arachidonic acid (AA) > alpha-linolenic acid (ALA)...
October 1995: Prostaglandins, Leukotrienes, and Essential Fatty Acids
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