Emily Evans-Hoeker, Zheng Wang, Henk Groen, Astrid E P Cantineau, Ann Thurin-Kjellberg, Christina Bergh, Joop S E Laven, Alexandra Dietz de Loos, Geranne Jiskoot, Jean-Patrice Baillargeon, Stefano Palomba, Kyra Sim, Lisa J Moran, Juan J Espinós, Trine Moholdt, Amy E Rothberg, Donna Shoupe, Annemieke Hoek, Richard S Legro, Ben W Mol, Rui Wang
INTRODUCTION: Dietary and/or physical activity interventions are often recommended for women with overweight or obesity as the first step prior to fertility treatment. However, randomised controlled trials (RCTs) so far have shown inconsistent results. Therefore, we propose this individual participant data meta-analysis (IPDMA) to evaluate the effectiveness and safety of dietary and/or physical activity interventions in women with infertility and overweight or obesity on reproductive, maternal and perinatal outcomes and to explore if there are subgroup(s) of women who benefit from each specific intervention or their combination (treatment-covariate interactions)...
November 7, 2022: BMJ Open