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https://www.readbyqxmd.com/read/29778182/evidence-for-involvement-of-the-fas-bcax-regulon-in-capsule-synthesis-by-streptococcus-equi
#1
Sridhar Velineni, John F Timoney
The constitutively expressed hyaluronic acid capsule is an important virulence factor of Streptococcus equi, the cause of equine strangles. Study of the genomic sequence of CF22caps-, a non-encapsulated mutant of S. equi CF22 generated by gamma (Co60 ) irradiation revealed a non-sense mutation in fasC (SEQ_0302), a sensor kinase gene in FasBCAX an operon with an important regulatory role in expression of streptococcal secreted virulence and matrix binding proteins. The mutation was associated with a significant (p < ...
June 2018: Veterinary Microbiology
https://www.readbyqxmd.com/read/29776593/heat-shock-influences-the-fatty-acid-composition-of-the-muscle-of-the-antarctic-fish-trematomus-bernacchii
#2
C Truzzi, S Illuminati, M Antonucci, G Scarponi, A Annibaldi
In the Ross Sea region (average temperature of -1.87 °C), shelf water warming up to +0.8-+1.4 °C is predicted by 2200, so there is an urgent need to understand how organisms can respond to rising temperatures. In this study, we analyzed the effect of a heat shock on the fatty acid (FAs) composition of muscle of the Antarctic teleost Trematomus bernacchii, caught in Terra Nova Bay (Ross Sea), and held in fish tanks at 0, +1 or +2 °C, for 1, 5 and 10 days. In general, heat shock produced, beyond a reduction in total lipid content correlated to the temperature, an increase in the percentage of saturated FAs, and a decrease in mono-unsaturated FAs; however, the level of poly-unsaturated FAs did not seem to directly correlate with temperature...
April 3, 2018: Marine Environmental Research
https://www.readbyqxmd.com/read/29775012/-the-clinical-value-of-china-savin-pollen-extract-used-for-skin-prick-test
#3
Kai Guan, J X Zhou, R Q Wang, J Yin, L L Wang, Y X Zhi, J L Sun, H Li, L P Wen, J Q Gu, R Tang, Z X Wang, L S Li, T Xu
Objective: The aim of this study is to evaluate the effectiveness and safety of China Savin pollen extract which was used for skin prick test (SPT) in the diagnosis of China Savin pollen allergy. Method: Patients with diagnosis of allergic diseases were collected from Allergy Department of Peking Union Medical College Hospital. All patients were given SPT with China Savin pollen extract, and the mean wheal diameter (MWD) was measured after 15 minutes. Receiver operating characteristic curve (ROC) analysis was performed based on the results of serum specific immunoglobulin E (sIgE)...
February 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29774529/inhibition-of-prmt3-activity-selectively-impairs-lxr-driven-transcription-of-hepatic-lipogenic-genes-in-vivo
#4
Joya E Nahon, Christianne Groeneveldt, Janine J Geerling, Miranda Van Eck, Menno Hoekstra
BACKGROUND AND PURPOSE: Agonists for the liver X receptor (LXR) are considered promising therapeutic moieties in cholesterol-driven diseases by promoting cellular cholesterol efflux pathways. However, current clinical application of these agents is hampered by the concomitant LXR-induced activation of a lipogenic transcriptional network, leading to hepatic steatosis. Recent studies have suggested that protein arginine methyltransferase 3 (PRMT3) may act as a selective co-activator of LXR activity...
May 18, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29772677/lambertianic-acid-sensitizes-non-small-cell-lung-cancers-to-trail-induced-apoptosis-via-inhibition-of-xiap-nf-%C3%AE%C2%BAb-and-activation-of-caspases-and-death-receptor-4
#5
Deok Soo Ahn, Hyo Jung Lee, Jisung Hwang, Hyukgyu Han, Bonglee Kim, BumSang Shim, Sung-Hoon Kim
Lambertianic acid (LA) is a biologically active compound from the leaves of Pinus koraiensis. In the present study, apoptotic mechanisms of LA plus TNF-related apoptosis-inducing ligand (TRAIL) were elucidated in non-small cell lung cancer cells (NSCLCs). Cytotoxicity assay, flow cytometry, immunoprecipitation, and Western blotting were performed. Here, combined treatment of LA and TRAIL increased cytotoxicity, sub-G1 population, cleaved poly (ADP-ribose) polymerase (PARP), and caspase3/8/9 in A549 and H1299 cells compared to LA or TRAIL alone...
May 16, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29772244/gender-difference-in-the-effect-of-progesterone-on-neonatal-hypoxic-ischemic-brain-injury-in-mouse
#6
Shuyu Dong, Qian Zhang, Delian Kong, Chao Zhou, Jie Zhou, Jingjing Han, Yan Zhou, Guoliang Jin, Xiaodong Hua, Jun Wang, Fang Hua
This study was to investigate the effects of progesterone (PROG) on neonatal hypoxic/ischemic (NHI) brain injury, the differences in effects between genders, and the underlying mechanisms. NHI brain injury was established in both male and female neonatal mice induced by occlusion of the left common carotid artery followed by hypoxia. The mice were treated with PROG or vehicle. Fluoro-Jade B staining (F-JB), long term behavior testing, and brain magnetic resonance image (MRI) were applied to evaluate neuronal death, neurological function, and brain damage...
May 14, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29771917/the-differentiation-of-preadipocytes-and-gene-expression-related-to-adipogenesis-in-ducks-anas-platyrhynchos
#7
Shasha Wang, Yang Zhang, Qi Xu, Xiaoya Yuan, Wangcheng Dai, Xiaokun Shen, Zhixiu Wang, Guobin Chang, Zhiquan Wang, Guohong Chen
Meat quality is closely related to adipose tissues in ducks, and adipogenesis is controlled by a complex network of transcription factors tightly acting at different stages of differentiation especially in ducks. The aim of this study was to establish the preadipocyte in vitro culture system and understand the biological characteristics of expansion of duck adipocyte tissue at the cellular and molecular level. We isolated pre-adipocytes from the subcutaneous fat of three breeds of duck and differentiated them into mature adipocytes using a mixture of insulin, rosiglitazone, dexamethasone, 3-isobutyl-1-methylxanthine, and oleic acid over 0,2, 4, 6, and 8 days...
2018: PloS One
https://www.readbyqxmd.com/read/29771834/family-functions-and-life-quality-of-parents-of-children-with-cleft-lip-and-palate
#8
Belma I Aslan, Ayşe Gülşen, Şadiye B Tirank, Kemal Findikçioğlu, F Deniz Uzuner, Hakan Tutar, Neslihan Üçüncü
OBJECTIVE: This study was designed to identify variables affecting family functions and life quality of parents with cleft lip and/or palate children. MATERIALS AND METHODS: Family Assesment Scale (FAS) and short form of World Health Organization quality of life (WHOQOL-BREF-TR) were used to measure family functions and life quality of parents. Questionnaire Forms were given to 146 parents: 74 having cleft lip and/or palate children (cleft-group), and the other 72 with healthy children (control-group)...
May 15, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29770949/selenium-ameliorates-afb-1-induced-excess-apoptosis-in-chicken-splenocytes-through-death-receptor-and-endoplasmic-reticulum-pathways
#9
Jing Fang, Panpan Zhu, Zhuangzhi Yang, Xi Peng, Zhicai Zuo, Hengmin Cui, Ping Ouyang, Gang Shu, Zhengli Chen, Chao Huang, Wentao Liu
Aflatoxin B1 (AFB1 ) can cause hepatotoxicity, genotoxicity, and immunosuppressive effects for a variety of organisms. Selenium (Se), as an essential nutrient element, plays important protective effects against cell apoptosis induced by AFB1 . This research aimed to reveal the ameliorative effects of selenium on AFB1 -induced excess apoptosis in chicken splenocytes through death receptor and endoplasmic reticulum pathways in vivo. Two hundred sixteen neonatal chickens, randomized into four treatments, were fed with basal diet (control treatment), 0...
May 16, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29770156/probing-into-the-mechanism-of-alkaline-citrus-extract-promoted-apoptosis-in-pulmonary-fibroblasts-of-bleomycin-induced-pulmonary-fibrosis-mice
#10
Qi Wu, Yao Zhou, Fan-Chao Feng, Yi-Han Jin, Zhi-Chao Wang, Xian-Mei Zhou
We extracted the primary pulmonary fibroblasts of the normal and bleomycin-induced pulmonary fibrosis mice and investigated the functioning mechanism of citrus alkaline extract (CAE) in the induction of pulmonary fibroblast apoptosis. The expression intensity of vimentin of the pulmonary fibroblasts in the model mice was higher than that in the normal mice. Meanwhile, the positive expression rate and expression intensity of alpha smooth muscle actin ( α -SMA) of the pulmonary fibroblasts in the model mice were higher than those in the normal mice...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29769471/-ministry-of-health-2015-penultimate-year-children-and-survey-and-research-project-promoting-the-parenting-support-actual-conditions-report-on-the-results-of-the-investigation-on-allergy-control-in-day-care-centers-admissions-children-of-allergic-diseases-situation
#11
Noriyuki Yanagida, Motohiro Ebisawa, Toshio Katsunuma, Jyoji Yoshizawa
BACKGROUND: There are no reports on the prevalence and social acceptance of food allergies (FAs) and FAinduced symptoms in nursery schools in Japan. PURPOSE: The purpose of this study is to clarify the current status of FA among children in nurseries. METHODS: Investigations were conducted in childcare facilities nationwide through survey request forms found on the Web page or sent via post. RESULT: We received responses from 15722 out of the 32210 institutions (48...
2018: Arerugī, [Allergy]
https://www.readbyqxmd.com/read/29768196/loss-of-abhd15-impairs-the-anti-lipolytic-action-of-insulin-by-altering-pde3b-stability-and-contributes-to-insulin-resistance
#12
Wenmin Xia, Ariane R Pessentheiner, Dina C Hofer, Melina Amor, Renate Schreiber, Gabriele Schoiswohl, Thomas O Eichmann, Evelyn Walenta, Bianca Itariu, Gerhard Prager, Hubert Hackl, Thomas Stulnig, Dagmar Kratky, Thomas Rülicke, Juliane G Bogner-Strauss
Elevated circulating fatty acids (FAs) contribute to obesity-associated metabolic complications, but the mechanisms by which insulin suppresses lipolysis are poorly understood. We show that α/β-hydrolase domain-containing 15 (ABHD15) is required for the anti-lipolytic action of insulin in white adipose tissue (WAT). Neither insulin nor glucose treatments can suppress FA mobilization in global and conditional Abhd15-knockout (KO) mice. Accordingly, insulin signaling is impaired in Abhd15-KO adipocytes, as indicated by reduced AKT phosphorylation, glucose uptake, and de novo lipogenesis...
May 15, 2018: Cell Reports
https://www.readbyqxmd.com/read/29767244/propranolol-induces-hemangioma-endothelial-cell-apoptosis-via-a-p53%C3%A2-bax-mediated-pathway
#13
Tian-Hua Yao, Parekejiang Pataer, Krishna Prasad Regmi, Xi-Wen Gu, Quan-Yan Li, Jing-Ting Du, Su-Meng Ge, Jun-Bo Tu
The use of propranolol for the treatment of infantile hemangioma (IH) has been widely investigated in recent years. However, the underlying therapeutic mechanism of propranolol for the treatment of IH remains poorly understood. The aim of the present study was to investigate the expression of proteins regulated by cellular tumor antigen p53 (p53) in associated apoptosis pathways in IH endothelial cells (HemECs) treated with propranolol. Furthermore, the present study aimed to investigate the exact apoptotic pathway underlying the therapeutic effect of propranolol against IH...
May 14, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29766819/synthesis-in-silico-molecular-docking-and-pharmacokinetic-studies-in-vitro-antimycobacterial-and-antimicrobial-studies-of-new-imidozolones-clubbed-with-thiazolidinedione
#14
Imran H Khan, Navin B Patel, Vatsal M Patel
BACKGROUND: A series of (E)-5-(4-((Z)-4-substitutedbenzylidene/2-thienylmethylene-5-oxo-2-phenyl-4,5-dihydro-1H-imidazol-1-yl) benzylidene)thiazolidine-2,4-dione were synthesized and evaluated for antimycobacterial and antimicrobial activity. All these ligands were docked against protein (InhA) Enoyl-ACP reductase of the type II fatty acid syntase (FAS-II) system, (PDB ID: 4COD). OBJECTIVE: In this report we have designed and synthesized azole scaffolds with good antitubercular activities as there is a real need to develop new candidates with less toxicity and more efficient toward pathogen...
May 15, 2018: Current Computer-aided Drug Design
https://www.readbyqxmd.com/read/29763727/antibacterial-activity-of-flavonoid-isolated-from-trianthema-decandra-against-pseudomonas-aeruginosa-and-molecular-docking-study-of-fabz
#15
R Geethalakshmi, Jagadish Chandrabose Sundaramurthi, D V L Sarada
The natural product flavonoid demonstrates an extensive sort of pharmacological properties including antimicrobial activity. Although its Pseudomonas aeruginosa inhibition has been discovered, no target for action against flavonoid has been revealed to date. The anti - P. aeruginosa activity of the 2 - (3', 4' dihydroxy-phenyl) - 3, 5, 7-trihydroxy-chromen-4-one isolated from T. decandra was evaluated by disc diffusion and minimum inhibitory concentration methods. The molecular docking of the flavonoid isolated from T...
May 12, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29762502/molecular-mechanisms-of-apoptosis-in-heparg-cell-line-induced-by-polyphyllin-vi-via-the-fas-death-pathway-and-mitochondrial-dependent-pathway
#16
Yi Liu, Xiaoxv Dong, Wenping Wang, Longtai You, Xingbin Yin, Chunjing Yang, Na Sai, Xin Leng, Jian Ni
Polyphyllin VI, which is an active saponin, is mainly isolated from traditional medicinal plant Paris polyphylla , which causes liver damage in rats. In the present study, we aimed to explore the potential cytotoxicity of polyphyllin VI on the growth of HepaRG cells and to determine the molecular mechanism. The results revealed that polyphyllin VI changed cell morphology and induced apoptosis in HepaRG cells. Flow cytometric assay displayed that polyphyllin VI promoted the generation of reactive oxygen species (ROS), depolarized the mitochondrial membrane potential (MMP), and induced S phase cell cycle arrest by decreasing the expression of cyclin A2 and CDK2, while significantly increasing the expression of p21 protein...
May 15, 2018: Toxins
https://www.readbyqxmd.com/read/29760682/daily-gene-expression-rhythms-in-rat-white-adipose-tissue-do-not-differ-between-subcutaneous-and-intra-abdominal-depots
#17
Rianne van der Spek, Eric Fliers, Susanne E la Fleur, Andries Kalsbeek
White adipose tissue (WAT) is present in different depots throughout the body. Although all depots are exposed to systemic humoral signals, they are not functionally identical. Studies in clock gene knockout animals and in shift workers suggest that daily rhythmicity may play an important role in lipid metabolism. Differences in rhythmicity between fat depots might explain differences in depot function; therefore, we measured mRNA expression of clock genes and metabolic genes on a 3-h interval over a 24-h period in the subcutaneous inguinal depot and in the intra-abdominal perirenal, epididymal, and mesenteric depots of male Wistar rats...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29759071/metformin-attenuates-triglyceride-accumulation-in-hepg2-cells-through-decreasing-stearyl-coenzyme-a-desaturase-1-expression
#18
Xiaopeng Zhu, Hongmei Yan, Mingfeng Xia, Xinxia Chang, Xi Xu, Liu Wang, Xiaoyang Sun, Yan Lu, Hua Bian, Xiaoying Li, Xin Gao
BACKGROUND: The prevalence of nonalcoholic fatty liver disease (NAFLD) has increased worldwide. Metformin decreases triglyceride (TG) accumulation in hepatocytes in vivo and in vitro. Stearyl-coenzyme A desaturase 1 (SCD1) knockout mice also show decreased liver TG accumulation; however, whether SCD1 plays a role in the effect of metformin on TG accumulation is unknown. Therefore, the aim of this study was to investigate whether SCD1 mediated the effect of metformin on TG accumulation...
May 14, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29758875/thifluzamide-affects-lipid-metabolism-in-zebrafish-danio-reio
#19
Yang Yang, Fengshou Dong, Xingang Liu, Jun Xu, Xiaohu Wu, Suzhen Qi, Wenxian Liu, Yongquan Zheng
Thifluzamide, a succinate dehydrogenase inhibitor (SDHI) fungicide, has been widely used in rice fields throughout the world and causes hepatotoxicity in zebrafish (Danio reio). This study was conducted to investigate the effect of thifluzamide on lipid metabolism in zebrafish after exposure to a control or, 0.019, 0.19, or 1.90mg/L thifluzamide for 28days. Following exposure, pathological changes in the liver were evaluated. Total cholesterol (TCHO) level, and triglyceride (TG) levels as well as hepatic lipase (HL), lipoprotein lipase (LPL), fatty acid synthetase (FAS) and carnitine palmitoyltransferase (CPT-I) activities were measured...
August 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29755604/probiotics-strains-modulate-gut-microbiota-and-lipid-metabolism-in-mule-ducks
#20
Maxime Even, Stéphane Davail, Mikael Rey, Annabelle Tavernier, Marianne Houssier, Marie Dominique Bernadet, Karine Gontier, Géraldine Pascal, Karine Ricaud
Background: Livestock production should respond to societal, environmental and economic changes. Since 2006 and the ban on antibiotics as growth factors in European Union, the use of probiotics has become widespread and has demonstrated the effect of intestinal microbiota on the performance of farm animals. Objective: The aim of this study was to investigate the effect of supplementation with Lactobacillus salivarius (as a probiotics strain or combined with other strains) on zootechnical performance, metabolic and immune gene expression and intestinal microbiota diversity in mule ducks using high-throughput sequencing and real-time PCR...
2018: Open Microbiology Journal
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