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https://www.readbyqxmd.com/read/28224236/wavenumber-selection-in-coupled-transport-equations
#1
Arnd Scheel, Angela Stevens
We study mechanisms for wavenumber selection in a minimal model for run-and-tumble dynamics. We show that nonlinearity in tumbling rates induces the existence of a plethora of traveling- and standing-wave patterns, as well as a subtle selection mechanism for the wavenumbers of spatio-temporally periodic waves. We comment on possible implications for rippling patterns observed in colonies of myxobacteria.
February 21, 2017: Journal of Mathematical Biology
https://www.readbyqxmd.com/read/28223963/corrigendum-feasibility-and-diagnostic-accuracy-of-ischemic-stroke-territory-recognition-based-on-two-dimensional-projections-of-three-dimensional-diffusion-mri-data
#2
Jana Katharina Wrosch, Bastian Volbers, Philipp Gölitz, Daniel Frederic Gilbert, Stefan Schwab, Arnd Dörfler, Johannes Kornhuber, Teja Wolfgang Groemer
[This corrects the article on p. 239 in vol. 6, PMID: 26635717.].
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28194500/the-influence-of-applied-internal-and-external-rotation-on-the-pivot-shift-phenomenon
#3
Sebastian Kopf, Volker Musahl, Carsten Perka, Ralf Kauert, Arnd Hoburg, Roland Becker
PURPOSE: The pivot shift test is performed in different techniques and the rotation of the tibia seems to have a significant impact on the amount of the pivot shift phenomenon. It has been hypothesised that external rotation will increase the phenomenon due to less tension at the iliotibial band in knee extension. METHODS: Twenty-four patients with unilateral anterior cruciate ligament insufficiency were included prospectively. The pivot shift test was performed bilaterally in internal and external tibial rotation under general anaesthesia...
February 14, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28187783/development-of-three-dimensional-prints-of-arthritic-joints-for-supporting-patients-awareness-to-structural-damage
#4
Arnd Kleyer, Laura Beyer, Christoph Simon, Fabian Stemmler, Matthias Englbrecht, Christian Beyer, Jürgen Rech, Bernhard Manger, Gerhard Krönke, Georg Schett, Axel J Hueber
BACKGROUND: Rheumatoid arthritis (RA) and psoriatic arthritis (PsA) result in severe joint destruction and functional disability if left untreated. We aim to develop tools that help patients with RA and PsA to understand and experience the impact of inflammatory joint disease on the integrity of their (juxta-articular) bone and increase adherence to medical treatment. In this study, we used high-resolution peripheral quantitative computed tomography (HR-pQCT) to develop 3D prototypes of patients' finger joints...
February 10, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28167801/caspase-3-and-gfap-as-early-markers-for-apoptosis-and-astrogliosis-in-shrna-induced-hippocampal-cytotoxicity
#5
Anne Günther, Vince Luczak, Ted Abel, Arnd Baumann
Genetic manipulation of cells and tissue by RNA interference has significantly contributed to the functional characterization of individual proteins and their role in physiological processes. Despite its versatility, RNA interference can have detrimental side effects, including reduced cell viability. We applied recombinant adeno-associated viruses by stereotaxic injection into the murine hippocampus to express different short hairpin RNA (shRNA) constructs along with eGFP. Tissue responses were assessed immunohistochemically for up to 8 weeks post infection...
February 6, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28130602/rapid-battery-depletion-and-loss-of-therapy-due-to-a-short-circuit-in-bipolar-dbs-for-essential-tremor
#6
Niels Allert, Michael Thomas Barbe, Lars Timmermann, Volker Arnd Coenen
Technical dysfunctions have been reported reducing efficacy of deep brain stimulation (DBS). Here, we report on an essential-tremor patient in whom a short circuit in bipolar DBS resulted not only in unilateral loss of therapy but also in high current flow and thereby rapid decline of the impulse-generator battery voltage from 2.83 V a week before the event to 2.54 V, indicating the need for an impulse-generator replacement. Immediate re-programming restored therapeutic efficacy. Moreover, the reduction in current flow allowed the battery voltage to recover without immediate surgical intervention to 2...
January 27, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28030856/criteria-for-determining-malignancy-in-pancreatic-intraductal-papillary-mucinous-neoplasm-based-on-computed-tomography
#7
Peter Mönnings, Orlin Belyaev, Waldemar Uhl, Arnd Giese, Andrea Tannapfel, Odo Köster, Juris J Meier
INTRODUCTION: Determining the dignity of intraductal papillary mucinous neoplasms (IPMNs) by imaging procedures is challenging. Various CT-based criteria were evaluated. PATIENTS AND METHODS: Preoperative CT scans from 47 patients with IPMN were analyzed. Predefined criteria of malignancy were compared between patients with benign (bIPMN; n = 28) and malignant (mIPMN; n = 19) tumors, and a summation score was determined. RESULTS: Preoperative carbohydrate-antigen 19-9 levels were higher in patients with mIPMN (p = 0...
2016: Digestion
https://www.readbyqxmd.com/read/28018163/prenatal-alcohol-exposure-in-rodents-as-a-promising-model-for-the-study-of-adhd-molecular-basis
#8
REVIEW
Argelia E Rojas-Mayorquín, Edgar Padilla-Velarde, Daniel Ortuño-Sahagún
A physiological parallelism, or even a causal effect relationship, can be deducted from the analysis of the main characteristics of the "Alcohol Related Neurodevelopmental Disorders" (ARND), derived from prenatal alcohol exposure (PAE), and the behavioral performance in the Attention-deficit/hyperactivity disorder (ADHD). These two clinically distinct disease entities, exhibits many common features. They affect neurological shared pathways, and also related neurotransmitter systems. We briefly review here these parallelisms, with their common and uncommon characteristics, and with an emphasis in the subjacent molecular mechanisms of the behavioral manifestations, that lead us to propose that PAE in rats can be considered as a suitable model for the study of ADHD...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28007690/deep-brain-stimulation-for-tremor-tractographic-versus-traditional-distinct-study-protocol-of-a-randomized-controlled-feasibility-trial
#9
Bastian Elmar Alexander Sajonz, Florian Amtage, Peter Christoph Reinacher, Carolin Jenkner, Tobias Piroth, Jürgen Kätzler, Horst Urbach, Volker Arnd Coenen
BACKGROUND: Essential tremor is a movement disorder that can result in profound disability affecting the quality of life. Medically refractory essential tremor can be successfully reduced by deep brain stimulation (DBS) traditionally targeting the thalamic ventral intermediate nucleus (Vim). Although this structure can be identified with magnetic resonance (MR) imaging nowadays, Vim-DBS electrodes are still implanted in the awake patient with intraoperative tremor testing to achieve satisfactory tremor control...
December 22, 2016: JMIR Research Protocols
https://www.readbyqxmd.com/read/27997033/brain-mechanisms-of-abnormal-temperature-perception-in-cold-allodynia-induced-by-ciguatoxin
#10
Anneka Eisenblätter, Richard Lewis, Arnd Dörfler, Clemens Forster, Katharina Zimmermann
OBJECTIVE: Cold allodynia occurs as a major symptom of neuropathic pain states. It remains poorly treated with current analgesics. Ciguatoxins (CTXs), ichthyosarcotoxins that cause ciguatera, produce a large peripheral sensitization to dynamic cold stimuli in Aδ-fibers by activating sodium channels without producing heat or mechanical allodynia. We used CTXs as a surrogate model of cold allodynia to dissect the framework of cold allodynia-activated central pain pathways. METHODS: Reversible cold allodynia was induced in healthy male volunteers by shallow intracutaneous injection of low millimolar concentrations of CTX into the dorsal skin of the forefoot...
January 2017: Annals of Neurology
https://www.readbyqxmd.com/read/27989897/phenotypic-changes-of-peripheral-blood-mononuclear-cells-upon-corticosteroid-treatment-in-idiopathic-intermediate-uveitis
#11
Karoline Walscheid, Toni Weinhage, Dirk Foell, Carsten Heinz, Maren Kasper, Arnd Heiligenhaus
We analyzed phenotype and function of peripheral blood mononuclear cells in 9 patients with active idiopathic intermediate uveitis (IIU) before and after 6 and 12weeks of systemic corticosteroid (CS) treatment and compared to 28 healthy individuals. Monocytes from IIU patients showed increased MHCII expression compared with controls (p=0.09). Treatment reduced expression of MHCII, CD86, CD39 and CD124 (all p<0.05), whereas the percentage of CD121b-expressing monocytes was increased by week 6 (p=0.039). Patients showed alterations in T cell polarization (Th1/Th2 ratio: patients 5...
October 28, 2016: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/27982759/mr-imaging-derived-oxygen-metabolism-and-neovascularization-characterization-for-grading-and-idh-gene-mutation-detection-of-gliomas
#12
Andreas Stadlbauer, Max Zimmermann, Melitta Kitzwögerer, Stefan Oberndorfer, Karl Rössler, Arnd Dörfler, Michael Buchfelder, Gertraud Heinz
Purpose To explore the diagnostic performance of physiological magnetic resonance (MR) imaging of oxygen metabolism and neovascularization activity for grading and characterization of isocitrate dehydrogenase (IDH) gene mutation status of gliomas. Materials and Methods This retrospective study had institutional review board approval; written informed consent was obtained from all patients. Eighty-three patients with histopathologically proven glioma (World Health Organization [WHO] grade II-IV) were examined with quantitative blood oxygen level-dependent imaging and vascular architecture mapping...
December 13, 2016: Radiology
https://www.readbyqxmd.com/read/27939988/amtar2-functional-characterization-of-a-honeybee-tyramine-receptor-stimulating-adenylyl-cyclase-activity
#13
Tina Reim, Sabine Balfanz, Arnd Baumann, Wolfgang Blenau, Markus Thamm, Ricarda Scheiner
The biogenic monoamines norepinephrine and epinephrine regulate important physiological functions in vertebrates. Insects such as honeybees do not synthesize these neuroactive substances. Instead, they employ octopamine and tyramine for comparable physiological functions. These biogenic amines activate specific guanine nucleotide-binding (G) protein-coupled receptors (GPCRs). Based on pharmacological data obtained on heterologously expressed receptors, α- and β-adrenergic-like octopamine receptors are better activated by octopamine than by tyramine...
January 2017: Insect Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/27888608/efficacy-and-safety-of-combined-intraventricular-fibrinolysis-with-lumbar-drainage-for-prevention-of-permanent-shunt-dependency-after-intracerebral-hemorrhage-with-severe-ventricular-involvement-a-randomized-trial-and-individual-patient-data-meta-analysis
#14
Dimitre Staykov, Joji B Kuramatsu, Jürgen Bardutzky, Bastian Volbers, Stefan T Gerner, Stephan P Kloska, Arnd Doerfler, Stefan Schwab, Hagen B Huttner
OBJECTIVE: Intraventricular hemorrhage (IVH) is a negative prognostic factor in intracerebral hemorrhage (ICH) and is associated with permanent shunt dependency in a substantial proportion of patients post-ICH. IVH treatment by intraventricular fibrinolysis (IVF) was recently linked to reduced mortality rates in the CLEAR III study and IVF represents a safe and effective strategy to hasten clot resolution that may reduce shunt rates. Additionally, promising results from observational studies reported reductions in shunt dependency for a combined treatment approach of IVF plus lumbar drains (LDs)...
January 2017: Annals of Neurology
https://www.readbyqxmd.com/read/27879083/ustekinumab-in-der-therapie-der-pustulosis-palmoplantaris-eine-fallserie-mit-neun-patienten
#15
Valeska Buder, Katharina Herberger, Arnd Jacobi, Matthias Augustin, Marc Alexander Radtke
HINTERGRUND: Die Pustulosis palmoplantaris ist eine chronisch entzündliche Hauterkrankung, die mit bedeutenden Einschränkungen der Lebensqualität und der Belastbarkeit einhergeht. Aufgrund von Zulassungsbeschränkungen und einem häufig therapierefraktären Verlauf sind die Behandlungsmöglichkeiten limitiert. PATIENTEN UND METHODIK: Nach zuvor frustranen Therapien erhielten 9 Patienten mit Pustulosis palmoplantaris nach Ausschluss einer latenten Tuberkulose Ustekinumab (45 mg Ustekinumab bei < 100 kg Körpergewicht [KG], 90 mg Ustekinumab > 100 kg KG) in Woche 0, 4, 12 und 24...
November 2016: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/27879067/ustekinumab-in-the-treatment-of-palmoplantar-pustular-psoriasis-a-case-series-of-nine-patients
#16
Valeska Buder, Katharina Herberger, Arnd Jacobi, Matthias Augustin, Marc Alexander Radtke
BACKGROUND: Palmoplantar pustular psoriasis is a chronic inflammatory skin disease that is associated with considerable impairment in quality of life and resilience. Given the lack of approved pharmacological agents for this indication and the frequently recalcitrant disease course, therapeutic options are limited. PATIENTS AND METHODS: Following unsatisfactory therapeutic attempts with other treatment modalities, nine patients (six women; three men) were treated with ustekinumab (45 mg in individuals < 100 kg body weight, 90 mg in individuals > 100 kg) at weeks 0, 4, 12, and 24...
November 2016: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/27869329/novel-compound-heterozygous-synaptojanin-1-mutation-causes-l-dopa-responsive-dystonia-parkinsonism-syndrome
#17
Marc-Alexander Rauschendorf, Meike Jost, Friedrich Stock, Andreas Zimmer, Bernd Rösler, Michel Rijntjes, Tobias Piroth, Volker Arnd Coenen, Peter Christoph Reinacher, Philipp T Meyer, Lars Frings, Cornelius Weiller, Judith Fischer, Stephan Klebe
No abstract text is available yet for this article.
November 21, 2016: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/27820809/regulation-of-autoantibody-activity-by-the-il-23-th17-axis-determines-the-onset-of-autoimmune-disease
#18
René Pfeifle, Tobias Rothe, Natacha Ipseiz, Hans U Scherer, Stephan Culemann, Ulrike Harre, Jochen A Ackermann, Martina Seefried, Arnd Kleyer, Stefan Uderhardt, Benjamin Haugg, Axel J Hueber, Patrick Daum, Gordon F Heidkamp, Changrong Ge, Sybille Böhm, Anja Lux, Wolfgang Schuh, Iryna Magorivska, Kutty S Nandakumar, Erik Lönnblom, Christoph Becker, Diana Dudziak, Manfred Wuhrer, Yoann Rombouts, Carolien A Koeleman, René Toes, Thomas H Winkler, Rikard Holmdahl, Martin Herrmann, Stephan Blüml, Falk Nimmerjahn, Georg Schett, Gerhard Krönke
The checkpoints and mechanisms that contribute to autoantibody-driven disease are as yet incompletely understood. Here we identified the axis of interleukin 23 (IL-23) and the TH17 subset of helper T cells as a decisive factor that controlled the intrinsic inflammatory activity of autoantibodies and triggered the clinical onset of autoimmune arthritis. By instructing B cells in an IL-22- and IL-21-dependent manner, TH17 cells regulated the expression of β-galactoside α2,6-sialyltransferase 1 in newly differentiating antibody-producing cells and determined the glycosylation profile and activity of immunoglobulin G (IgG) produced by the plasma cells that subsequently emerged...
January 2017: Nature Immunology
https://www.readbyqxmd.com/read/27811481/dose-and-time-dependent-cellular-effects-of-cold-atmospheric-pressure-plasma-evaluated-in-3d-skin-models
#19
Cornelia Wiegand, Sarah Fink, Oliver Beier, Kerstin Horn, Andreas Pfuch, Arnd Schimanski, Bernd Grünler, Uta-Christina Hipler, Peter Elsner
BACKGROUND: Application of cold atmospheric pressure plasmas (CAPs) in or on the human body was termed 'plasma medicine'. So far, plasmas were utilized for sterilization of implants, other heat-sensitive products, or employed for chemical surface modifications. By now, CAPs are further used effectively for wound treatment. The present study analyses the effect of a plasma jet with air or nitrogen as process gas, previously evaluated for antimicrobial efficacy, on human cells using a 3D skin model...
2016: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/27787923/age-and-sex-dependent-changes-of-intra-articular-cortical-and-trabecular-bone-structure-and-the-effects-of-rheumatoid-arthritis
#20
David Simon, Arnd Kleyer, Fabian Stemmler, Christoph Simon, Andreas Berlin, Axel J Hueber, Judith Haschka, Nina Renner, Camille Figueiredo, Winfried Neuhuber, Thomas Buder, Matthias Englbrecht, Juergen Rech, Klaus Engelke K, Georg Schett
The objective of this cross-sectional study was to define normal sex and age-dependent values of intra-articular bone mass and microstructures in the metacarpal heads of healthy individuals by high-resolution peripheral quantitative computed tomography (HR-pQCT) and test the effect of rheumatoid arthritis (RA) on these parameters. Human cadaveric metacarpal heads were used to exactly define intra-articular bone. Healthy individuals of different sex and age categories and RA patients with similar age- and sex-distribution received HR-pQCT scans of the second metacarpal head and the radius...
October 27, 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
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