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https://www.readbyqxmd.com/read/28541870/palmoplantar-pustulosis-a-cross-sectional-analysis-in-germany
#1
Dagmar Wilsmann-Theis, Arnd Jacobi, Yvonne Frambach, Sandra Philipp, Ansgar Weyergraf, Tillmann Schill, Kirsten Steinz, Sascha Gerdes, Rotraut Mössner
BACKGROUND: Palmoplantar pustulosis (PPP) is a recalcitrant chronic inflammatory skin disease. Data relevant for the medical care of patients with PPP are scarce. Thus, the aim of this work was to investigate the disease burden, clinical characteristics, and comorbidity of PPP patients in Germany. PATIENTS AND METHODS: PPP patients were examined in a crosssectional study at seven specialized psoriasis centers in Germany. RESULTS: Of the 172 included patients with PPP, 79...
April 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28531226/intercenter-validation-of-a-knowledge-based-model-for-automated-planning-of-volumetric-modulated-arc-therapy-for-prostate-cancer-the-experience-of-the-german-rapidplan-consortium
#2
Carolin Schubert, Oliver Waletzko, Christian Weiss, Dirk Voelzke, Sevda Toperim, Arnd Roeser, Silvia Puccini, Marc Piroth, Christian Mehrens, Jan-Dirk Kueter, Kirsten Hierholz, Karsten Gerull, Antonella Fogliata, Andreas Block, Luca Cozzi
PURPOSE: To evaluate the performance of a model-based optimisation process for volumetric modulated arc therapy applied to prostate cancer in a multicentric cooperative group. The RapidPlan (RP) knowledge-based engine was tested for the planning of Volumetric modulated arc therapy with RapidArc on prostate cancer patients. The study was conducted in the frame of the German RapidPlan Consortium (GRC). METHODS AND MATERIALS: 43 patients from one institute of the GRC were used to build and train a RP model...
2017: PloS One
https://www.readbyqxmd.com/read/28505676/-new-therapeutic-approaches-in-inflammatory-diseases-of-the-eye-targeting-lymphangiogenesis-and-cellular-immunity-research-unit-for-2240-presents-itself
#3
Claus Cursiefen, Felix Bock, Thomas Clahsen, Birgit Regenfuss, Andre Reis, Philipp Steven, Ludwig M Heindl, Jacobus J Bosch, Deniz Hos, Sabine Eming, Rafael Grajewski, Arnd Heiligenhaus, Sascha Fauser, Jennifer Austin, Thomas Langmann
Background Ophthalmology, principally, is a very successful subdiscipline in medicine. Nonetheless, there are still unmet medical needs which necessitate translational research. Methods The funding instrument of a Research Unit (RU) of the German Research Foundation (DFG) is presented as exemplified by the RU 2240 at the Department of Ophthalmology at the University of Cologne. Results The Research Unit integrates different research groups working on pathologic ocular inflammation, macrophages/microglia and (lymph)angiogenesis to collaborate in a synergistic way...
May 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28505673/-hla-b27-positive-acute-anterior-uveitis-a-translational-perspective
#4
Arnd Heiligenhaus, Maren Kasper, Rafael Grajewski
Background HLA-B27 positive acute anterior uveitis is the most common type of uveitis, and it is an autoimmune disease that can be triggered by infections. The precise mechanism of the interaction between involved microbes (mostly gram negative bacteria) and the host immune system is not clear. The disease probably results from an imbalance between pro- and anti-inflammatory components. Project description This article gives a compact overview about the current knowledge of the clinic and the etiopathogenesis of acute anterior uveitis as a basis for future research approaches...
May 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28505672/-translational-research-in-ophthalmology-is-important
#5
Claus Cursiefen, Arnd Heiligenhaus
No abstract text is available yet for this article.
May 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28493323/rheumatoid-arthritis-is-characterized-by-early-changes-of-the-cortical-micro-channel-comic-system-in-the-bare-area-of-the-joints
#6
David Werner, David Simon, Matthias Englbrecht, Fabian Stemmler, Christoph Simon, Andreas Berlin, Judith Haschka, Nina Renner, Thomas Buder, Klaus Engelke, Axel J Hueber, Jürgen Rech, Georg Schett, Arnd Kleyer
OBJECTIVE: To characterize the specific structural properties of the erosion-prone bare area of the human joint and to search for early microstructural changes in this region during rheumatoid arthritis Methods: An initial cadaveric study was used for exact localization of the bare area of the metacarpal heads, detection of cortical micro-channels (CoMiCs) in this region by high-resolution peripheral computed tomography (HR-pQCT) and, after anatomical dissection, their validation by micro-computed tomography (μCT)...
May 10, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28488162/can-the-metaphyseal-anchored-metha-short-stem-safely-be-revised-with-a-standard-cls-stem-a-biomechanical-analysis
#7
Shuang G Yan, Matthias Woiczinski, Tobias F Schmidutz, Patrick Weber, Alexander C Paulus, Arnd Steinbrück, Volkmar Jansson, Florian Schmidutz
PURPOSE: Short stem total hip arthroplasty (SHA) has gained increasing popularity as it conserves bone stock and is supposed to allow revision with a conventional stem. However, no study has evaluated whether the revision of a SHA with a standard total hip arthroplasty (THA) stem provides sufficient primary stability to allow osseous integration. METHODS: A neck preserving SHA (Metha) and a standard THA (CLS) stem were implanted into six composite femurs respectively and dynamically loaded (300-1700 N, 1 Hz)...
May 9, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28477180/value-of-flat-detector-computed-tomography-angiography-with-intravenous-contrast-media-injection-in-the-evaluation-and-treatment-of-acutely-ruptured-aneurysms-of-the-acoma-complex-a%C3%A2-single-center-experience-in-15%C3%A2-cases
#8
Julie Rösch, Stefan Lang, Philipp Gölitz, Bernd Kallmünzer, Karl Rössler, Arnd Doerfler, Tobias Struffert
OBJECTIVE: To illustrate the added value of flat-detector computed tomography angiography with intravenous contrast media injection (intravenous FDCTA) in the evaluation of complex A1/A2/AcomA aneurysms. PATIENTS AND METHODS: We retrospectively reviewed 15 patients with ruptured aneurysms. In each patient, an intravenous FDCTA was performed and its diagnostic value investigated. RESULTS: In all patients, FDCTA contributed relevant additional information concerning the anatomy of the A1/A2/AcomA complex and the relationship of the aneurysm neck to these vascular structures, which could not be gained by 2D- and 3D-DSA, and changed the management in 33% of the patients (5 out of 15)...
May 5, 2017: Clinical Neuroradiology
https://www.readbyqxmd.com/read/28470828/neurological-and-neuropsychological-effects-of-low-and-moderate-prenatal-alcohol-exposure
#9
REVIEW
Erika Comasco, Jenny Rangmar, Ulf J Eriksson, Lars Oreland
Several explanations for the diverse results in research on Foetal Alcohol Spectrum Disorders (FASD) or Alcohol-Related Neuro-developmental Disorder (ARND) might be at hand: timing, amount and patterns of alcohol exposure, as well as complex epigenetic responses. The genetic background of the offspring and its interaction with other prenatal and postnatal environmental cues are likely also of importance. In the present report, key findings about the possible effects of low and moderate doses of maternal alcohol intake on the neuropsychological development of the offspring are reviewed and plausible mechanisms discussed...
May 4, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28455166/biomechanical-performance-of-a-collagen-meniscus-implant-with-regard-to-suture-material-and-irrigation-fluid
#10
Clemens Gwinner, Philipp von Roth, Sebastian Schmidt, Jan-Erik Ode, Dag Wulsten, Arnd Hoburg
BACKGROUND: The role of meniscus scaffolds remains controversial as failure rates remain high. The aim of this study was to evaluate the pullout strength of different suture materials used for fixation of the Collagen Meniscus Implant (CMI) regarding different suture materials, and type or temperature of irrigation fluid. METHODS: One-hundred and twelve specimens were utilized with horizontal sutures and mounted to a dedicated test device. Loads were applied perpendicular to the CMI, until failure...
April 25, 2017: Knee
https://www.readbyqxmd.com/read/28430885/lesion-mapping-of-stroke-related-erectile-dysfunction
#11
Klemens Winder, Frank Seifert, Martin Köhrmann, Carl Crodel, Stephan Kloska, Arnd Dörfler, Katharina M Hösl, Stefan Schwab, Max J Hilz
Acute ischaemic stroke in brain areas contributing to male sexual function may impair erectile function depending on the lesion site. This study intended to determine associations between stroke-related erectile dysfunction and cerebral ischaemic lesion sites using voxel-based lesion mapping. In 52 males (mean age 60.5 ± 10.5 years) with first-ever ischaemic strokes, we assessed erectile function after and retrospectively 3 months prior to the stroke using scores of the 5-item International Index of Erectile Function-5 questionnaire...
June 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28389463/vitreous-microrna-levels-as-diagnostic-biomarkers-for-vitreo-retinal-lymphoma
#12
Vinodh Kakkassery, Roland Schroers, Sarah E Coupland, M Ilan Wunderlich, Marc Schargus, Carsten Heinz, Susanne Wasmuth, Arnd Heiligenhaus, Guido Ahle, Patrick Lenoble, Uwe Schlegel, Wolff Schmiegel, H Burkhard Dick, Alexander Baraniskin
No abstract text is available yet for this article.
April 7, 2017: Blood
https://www.readbyqxmd.com/read/28386738/manufacturing-of-recombinant-human-follicle-stimulating-hormone-ovaleap-%C3%A2-xm17-comparability-with-gonal-f-%C3%A2-and-performance-consistency
#13
Rainer Winstel, Juergen Wieland, Beate Gertz, Arnd Mueller, Hermann Allgaier
Ovaleap(®) (XM17) is a recombinant human follicle-stimulating hormone to treat infertility by inducing ovulation or controlled ovarian stimulation for assisted reproductive technology (ART) procedures. Ovaleap(®) (follitropin-α) was approved by the European Medicines Agency in 2013 as a biosimilar medicinal product to the reference medicine, Gonal-f(®). Information is often not easily accessible and/or publicly available regarding the rigorous manufacturing procedures for biosimilars. Objectives of the current analysis were to report on validation procedures for the Ovaleap(®) manufacturing process, to compare the characteristics of Ovaleap(®) versus Gonal-f(®), and to describe the performance and consistency of Ovaleap(®)...
June 2017: Drugs in R&D
https://www.readbyqxmd.com/read/28384507/european-union-research-in-support-of-environment-and-health-building-scientific-evidence-base-for-policy
#14
REVIEW
Tuomo Karjalainen, Arnd Hoeveler, Ruxandra Draghia-Akli
Opinion polls show that the European Union citizens are increasingly concerned about the impact of environmental factors on their health. In order to respond and provide solid scientific evidence for the numerous policies related to the protection of human health and the environment managed at the Union level, the European Union made a substantial investment in research and innovation in the past two decades through its Framework Programmes for Research and Technological Development, including the current programme, Horizon 2020, which started in 2014...
June 2017: Environment International
https://www.readbyqxmd.com/read/28381366/nocturnal-incontinence-in-children-with-fetal-alcohol-spectrum-disorders-fasd-in-a-south-african-cohort
#15
Sylvia Roozen, Leana Olivier, Justine Niemczyk, Alexander von Gontard, Gjalt-Jorn Y Peters, Gerjo Kok, Denis Viljoen, Leopold Curfs
INTRODUCTION: Fetal alcohol spectrum disorders (FASD) are one of the leading preventable causes of intellectual disabilities (ID). Not much is known about the topic of pediatric incontinence related to FASD, for example nocturnal enuresis (NE), daytime urinary incontinence (DUI), and fecal incontinence (FI). So far, incontinence problems have been examined among children with other specific syndromes. OBJECTIVE: The aim of the present study is to investigate the possible presence of incontinence among children with FASD in a South African cohort...
March 23, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28297952/complex-path-prediction-of-resonance-assisted-tunneling-in-mixed-systems
#16
Felix Fritzsch, Arnd Bäcker, Roland Ketzmerick, Normann Mertig
We present a semiclassical prediction of regular-to-chaotic tunneling in systems with a mixed phase space, including the effect of a nonlinear resonance chain. We identify complex paths for direct and resonance-assisted tunneling in the phase space of an integrable approximation with one nonlinear resonance chain. We evaluate the resonance-assisted contribution analytically and give a prediction based on just a few properties of the classical phase space. For the standard map excellent agreement with numerically determined tunneling rates is observed...
February 2017: Physical Review. E
https://www.readbyqxmd.com/read/28283867/postoperative-neuroimaging-analysis-of-drt-deep-brain-stimulation-revision-surgery-for-complicated-essential-tremor
#17
Volker Arnd Coenen, Balint Varkuti, Yaroslav Parpaley, Sabine Skodda, Thomas Prokop, Horst Urbach, Meng Li, Peter Christoph Reinacher
BACKGROUND: We report a patient who received conventional bilateral deep brain stimulation of the ventral intermediate nucleus of thalamus (Vim) for the treatment of medication refractory essential tremor (ET). After initial beneficial effects, therapeutic efficacy was lost due to a loss of control of his proximal trunkal and extremity tremor. The patient received successful diffusion tensor magnetic resonance imaging fiber tractographic (DTI FT)-assisted DBS revision surgery targeting the dentato-rubro-thalamic tract (DRT) in the subthalamic region (STR)...
May 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28283611/bacteremia-in-children-3-to-36-months-old-after-introduction-of-conjugated-pneumococcal-vaccines
#18
Tara L Greenhow, Yun-Yi Hung, Arnd Herz
BACKGROUND AND OBJECTIVES: In June 2010, Kaiser Permanente Northern California replaced all 7-valent pneumococcal conjugate vaccine (PCV7) vaccines with the 13-valent pneumococcal conjugate vaccine (PCV13). Our objectives were to compare the incidence of bacteremia in children 3 to 36 months old by 3 time periods: pre-PCV7, post-PCV7/pre-PCV13, and post-PCV13. METHODS: We designed a retrospective review of the electronic medical records of all blood cultures collected on children 3 to 36 months old at Kaiser Permanente Northern California from September 1, 1998 to August 31, 2014 in outpatient clinics, in emergency departments, and in the first 24 hours of hospitalization...
March 10, 2017: Pediatrics
https://www.readbyqxmd.com/read/28273720/recurrence-of-glioblastoma-is-associated-with-elevated-microvascular-transit-time-heterogeneity-and-increased-hypoxia
#19
Andreas Stadlbauer, Kim Mouridsen, Arnd Doerfler, Mikkel Bo Hansen, Stefan Oberndorfer, Max Zimmermann, Michael Buchfelder, Gertraud Heinz, Karl Roessler
Dynamic susceptibility contrast (DSC) perfusion MRI provide information about differences in macro- and microvasculature when executed with gradient-echo (GE; sensitive to macrovasculature) and spin-echo (SE; sensitive to microvasculature) contrast. This study investigated whether there are differences between macro- and microvascular transit time heterogeneity (MVTH and µVTH) and tissue oxygen tension (PO2mit) in newly-diagnosed and recurrent glioblastoma. Fifty-seven patients with glioblastoma (25 newly-diagnosed/32 recurrent) were examined with GE- and SE-DSC perfusion sequences, and a quantitative blood-oxygen-level-dependent (qBOLD) approach...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28237832/central-nervous-system-anomalies-in-two-females-with-borjeson-forssman-lehmann-syndrome
#20
Burkhard S Kasper, Arnd Dörfler, Nataliya Di Donato, Ekkehard M Kasper, Dagmar Wieczorek, Juliane Hoyer, Christiane Zweier
Borjeson-Forssman-Lehmann syndrome (BFLS) is a rare disorder caused by mutations in the PHF6 gene. It manifests as syndromic X-linked recessive intellectual disability (ID) in males and as sporadic ID due to de novo mutations in females. Clinical features include variable ID and a range of somatic manifestations constituting a distinct phenotype in both males and females, respectively, including seizures in a few. Central nervous system (CNS) imaging data are largely unavailable for BFLS. Here we report on CNS MRI findings from two female individuals with BFLS due to a de novo duplication in PHF6 who presented with typical BFLS and epilepsy...
April 2017: Epilepsy & Behavior: E&B
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