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https://www.readbyqxmd.com/read/28297952/complex-path-prediction-of-resonance-assisted-tunneling-in-mixed-systems
#1
Felix Fritzsch, Arnd Bäcker, Roland Ketzmerick, Normann Mertig
We present a semiclassical prediction of regular-to-chaotic tunneling in systems with a mixed phase space, including the effect of a nonlinear resonance chain. We identify complex paths for direct and resonance-assisted tunneling in the phase space of an integrable approximation with one nonlinear resonance chain. We evaluate the resonance-assisted contribution analytically and give a prediction based on just a few properties of the classical phase space. For the standard map excellent agreement with numerically determined tunneling rates is observed...
February 2017: Physical Review. E
https://www.readbyqxmd.com/read/28283867/postoperative-neuroimaging-analysis-of-drt-deep-brain-stimulation-revision-surgery-for-complicated-essential-tremor
#2
Volker Arnd Coenen, Balint Varkuti, Yaroslav Parpaley, Sabine Skodda, Thomas Prokop, Horst Urbach, Meng Li, Peter Christoph Reinacher
BACKGROUND: We report a patient who received conventional bilateral deep brain stimulation of the ventral intermediate nucleus of thalamus (Vim) for the treatment of medication refractory essential tremor (ET). After initial beneficial effects, therapeutic efficacy was lost due to a loss of control of his proximal trunkal and extremity tremor. The patient received successful diffusion tensor magnetic resonance imaging fiber tractographic (DTI FT)-assisted DBS revision surgery targeting the dentato-rubro-thalamic tract (DRT) in the subthalamic region (STR)...
March 10, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28283611/bacteremia-in-children-3-to-36-months-old-after-introduction-of-conjugated-pneumococcal-vaccines
#3
Tara L Greenhow, Yun-Yi Hung, Arnd Herz
BACKGROUND AND OBJECTIVES: In June 2010, Kaiser Permanente Northern California replaced all 7-valent pneumococcal conjugate vaccine (PCV7) vaccines with the 13-valent pneumococcal conjugate vaccine (PCV13). Our objectives were to compare the incidence of bacteremia in children 3 to 36 months old by 3 time periods: pre-PCV7, post-PCV7/pre-PCV13, and post-PCV13. METHODS: We designed a retrospective review of the electronic medical records of all blood cultures collected on children 3 to 36 months old at Kaiser Permanente Northern California from September 1, 1998 to August 31, 2014 in outpatient clinics, in emergency departments, and in the first 24 hours of hospitalization...
March 10, 2017: Pediatrics
https://www.readbyqxmd.com/read/28273720/recurrence-of-glioblastoma-is-associated-with-elevated-microvascular-transit-time-heterogeneity-and-increased-hypoxia
#4
Andreas Stadlbauer, Kim Mouridsen, Arnd Doerfler, Mikkel Bo Hansen, Stefan Oberndorfer, Max Zimmermann, Michael Buchfelder, Gertraud Heinz, Karl Roessler
Dynamic susceptibility contrast (DSC) perfusion MRI provide information about differences in macro- and microvasculature when executed with gradient-echo (GE; sensitive to macrovasculature) and spin-echo (SE; sensitive to microvasculature) contrast. This study investigated whether there are differences between macro- and microvascular transit time heterogeneity (MVTH and µVTH) and tissue oxygen tension (PO2mit) in newly-diagnosed and recurrent glioblastoma. Fifty-seven patients with glioblastoma (25 newly-diagnosed/32 recurrent) were examined with GE- and SE-DSC perfusion sequences, and a quantitative blood-oxygen-level-dependent (qBOLD) approach...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28237832/central-nervous-system-anomalies-in-two-females-with-borjeson-forssman-lehmann-syndrome
#5
Burkhard S Kasper, Arnd Dörfler, Nataliya Di Donato, Ekkehard M Kasper, Dagmar Wieczorek, Juliane Hoyer, Christiane Zweier
Borjeson-Forssman-Lehmann syndrome (BFLS) is a rare disorder caused by mutations in the PHF6 gene. It manifests as syndromic X-linked recessive intellectual disability (ID) in males and as sporadic ID due to de novo mutations in females. Clinical features include variable ID and a range of somatic manifestations constituting a distinct phenotype in both males and females, respectively, including seizures in a few. Central nervous system (CNS) imaging data are largely unavailable for BFLS. Here we report on CNS MRI findings from two female individuals with BFLS due to a de novo duplication in PHF6 who presented with typical BFLS and epilepsy...
February 23, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28224236/wavenumber-selection-in-coupled-transport-equations
#6
Arnd Scheel, Angela Stevens
We study mechanisms for wavenumber selection in a minimal model for run-and-tumble dynamics. We show that nonlinearity in tumbling rates induces the existence of a plethora of traveling- and standing-wave patterns, as well as a subtle selection mechanism for the wavenumbers of spatio-temporally periodic waves. We comment on possible implications for rippling patterns observed in colonies of myxobacteria.
February 21, 2017: Journal of Mathematical Biology
https://www.readbyqxmd.com/read/28223963/corrigendum-feasibility-and-diagnostic-accuracy-of-ischemic-stroke-territory-recognition-based-on-two-dimensional-projections-of-three-dimensional-diffusion-mri-data
#7
Jana Katharina Wrosch, Bastian Volbers, Philipp Gölitz, Daniel Frederic Gilbert, Stefan Schwab, Arnd Dörfler, Johannes Kornhuber, Teja Wolfgang Groemer
[This corrects the article on p. 239 in vol. 6, PMID: 26635717.].
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28194500/the-influence-of-applied-internal-and-external-rotation-on-the-pivot-shift-phenomenon
#8
Sebastian Kopf, Volker Musahl, Carsten Perka, Ralf Kauert, Arnd Hoburg, Roland Becker
PURPOSE: The pivot shift test is performed in different techniques and the rotation of the tibia seems to have a significant impact on the amount of the pivot shift phenomenon. It has been hypothesised that external rotation will increase the phenomenon due to less tension at the iliotibial band in knee extension. METHODS: Twenty-four patients with unilateral anterior cruciate ligament insufficiency were included prospectively. The pivot shift test was performed bilaterally in internal and external tibial rotation under general anaesthesia...
February 14, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28187783/development-of-three-dimensional-prints-of-arthritic-joints-for-supporting-patients-awareness-to-structural-damage
#9
Arnd Kleyer, Laura Beyer, Christoph Simon, Fabian Stemmler, Matthias Englbrecht, Christian Beyer, Jürgen Rech, Bernhard Manger, Gerhard Krönke, Georg Schett, Axel J Hueber
BACKGROUND: Rheumatoid arthritis (RA) and psoriatic arthritis (PsA) result in severe joint destruction and functional disability if left untreated. We aim to develop tools that help patients with RA and PsA to understand and experience the impact of inflammatory joint disease on the integrity of their (juxta-articular) bone and increase adherence to medical treatment. In this study, we used high-resolution peripheral quantitative computed tomography (HR-pQCT) to develop 3D prototypes of patients' finger joints...
February 10, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28167801/caspase-3-and-gfap-as-early-markers-for-apoptosis-and-astrogliosis-in-shrna-induced-hippocampal-cytotoxicity
#10
Anne Günther, Vince Luczak, Ted Abel, Arnd Baumann
Genetic manipulation of cells and tissue by RNA interference has significantly contributed to the functional characterization of individual proteins and their role in physiological processes. Despite its versatility, RNA interference can have detrimental side effects, including reduced cell viability. We applied recombinant adeno-associated viruses by stereotaxic injection into the murine hippocampus to express different short hairpin RNA (shRNA) constructs along with eGFP. Tissue responses were assessed immunohistochemically for up to 8 weeks post infection...
February 6, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28130602/rapid-battery-depletion-and-loss-of-therapy-due-to-a-short-circuit-in-bipolar-dbs-for-essential-tremor
#11
Niels Allert, Michael Thomas Barbe, Lars Timmermann, Volker Arnd Coenen
Technical dysfunctions have been reported reducing efficacy of deep brain stimulation (DBS). Here, we report on an essential-tremor patient in whom a short circuit in bipolar DBS resulted not only in unilateral loss of therapy but also in high current flow and thereby rapid decline of the impulse-generator battery voltage from 2.83 V a week before the event to 2.54 V, indicating the need for an impulse-generator replacement. Immediate re-programming restored therapeutic efficacy. Moreover, the reduction in current flow allowed the battery voltage to recover without immediate surgical intervention to 2...
January 27, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28030856/criteria-for-determining-malignancy-in-pancreatic-intraductal-papillary-mucinous-neoplasm-based-on-computed-tomography
#12
Peter Mönnings, Orlin Belyaev, Waldemar Uhl, Arnd Giese, Andrea Tannapfel, Odo Köster, Juris J Meier
INTRODUCTION: Determining the dignity of intraductal papillary mucinous neoplasms (IPMNs) by imaging procedures is challenging. Various CT-based criteria were evaluated. PATIENTS AND METHODS: Preoperative CT scans from 47 patients with IPMN were analyzed. Predefined criteria of malignancy were compared between patients with benign (bIPMN; n = 28) and malignant (mIPMN; n = 19) tumors, and a summation score was determined. RESULTS: Preoperative carbohydrate-antigen 19-9 levels were higher in patients with mIPMN (p = 0...
2016: Digestion
https://www.readbyqxmd.com/read/28018163/prenatal-alcohol-exposure-in-rodents-as-a-promising-model-for-the-study-of-adhd-molecular-basis
#13
REVIEW
Argelia E Rojas-Mayorquín, Edgar Padilla-Velarde, Daniel Ortuño-Sahagún
A physiological parallelism, or even a causal effect relationship, can be deducted from the analysis of the main characteristics of the "Alcohol Related Neurodevelopmental Disorders" (ARND), derived from prenatal alcohol exposure (PAE), and the behavioral performance in the Attention-deficit/hyperactivity disorder (ADHD). These two clinically distinct disease entities, exhibits many common features. They affect neurological shared pathways, and also related neurotransmitter systems. We briefly review here these parallelisms, with their common and uncommon characteristics, and with an emphasis in the subjacent molecular mechanisms of the behavioral manifestations, that lead us to propose that PAE in rats can be considered as a suitable model for the study of ADHD...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28007690/deep-brain-stimulation-for-tremor-tractographic-versus-traditional-distinct-study-protocol-of-a-randomized-controlled-feasibility-trial
#14
Bastian Elmar Alexander Sajonz, Florian Amtage, Peter Christoph Reinacher, Carolin Jenkner, Tobias Piroth, Jürgen Kätzler, Horst Urbach, Volker Arnd Coenen
BACKGROUND: Essential tremor is a movement disorder that can result in profound disability affecting the quality of life. Medically refractory essential tremor can be successfully reduced by deep brain stimulation (DBS) traditionally targeting the thalamic ventral intermediate nucleus (Vim). Although this structure can be identified with magnetic resonance (MR) imaging nowadays, Vim-DBS electrodes are still implanted in the awake patient with intraoperative tremor testing to achieve satisfactory tremor control...
December 22, 2016: JMIR Research Protocols
https://www.readbyqxmd.com/read/27997033/brain-mechanisms-of-abnormal-temperature-perception-in-cold-allodynia-induced-by-ciguatoxin
#15
Anneka Eisenblätter, Richard Lewis, Arnd Dörfler, Clemens Forster, Katharina Zimmermann
OBJECTIVE: Cold allodynia occurs as a major symptom of neuropathic pain states. It remains poorly treated with current analgesics. Ciguatoxins (CTXs), ichthyosarcotoxins that cause ciguatera, produce a large peripheral sensitization to dynamic cold stimuli in Aδ-fibers by activating sodium channels without producing heat or mechanical allodynia. We used CTXs as a surrogate model of cold allodynia to dissect the framework of cold allodynia-activated central pain pathways. METHODS: Reversible cold allodynia was induced in healthy male volunteers by shallow intracutaneous injection of low millimolar concentrations of CTX into the dorsal skin of the forefoot...
January 2017: Annals of Neurology
https://www.readbyqxmd.com/read/27989897/phenotypic-changes-of-peripheral-blood-mononuclear-cells-upon-corticosteroid-treatment-in-idiopathic-intermediate-uveitis
#16
Karoline Walscheid, Toni Weinhage, Dirk Foell, Carsten Heinz, Maren Kasper, Arnd Heiligenhaus
We analyzed phenotype and function of peripheral blood mononuclear cells in 9 patients with active idiopathic intermediate uveitis (IIU) before and after 6 and 12weeks of systemic corticosteroid (CS) treatment and compared to 28 healthy individuals. Monocytes from IIU patients showed increased MHCII expression compared with controls (p=0.09). Treatment reduced expression of MHCII, CD86, CD39 and CD124 (all p<0.05), whereas the percentage of CD121b-expressing monocytes was increased by week 6 (p=0.039). Patients showed alterations in T cell polarization (Th1/Th2 ratio: patients 5...
October 28, 2016: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/27982759/mr-imaging-derived-oxygen-metabolism-and-neovascularization-characterization-for-grading-and-idh-gene-mutation-detection-of-gliomas
#17
Andreas Stadlbauer, Max Zimmermann, Melitta Kitzwögerer, Stefan Oberndorfer, Karl Rössler, Arnd Dörfler, Michael Buchfelder, Gertraud Heinz
Purpose To explore the diagnostic performance of physiological magnetic resonance (MR) imaging of oxygen metabolism and neovascularization activity for grading and characterization of isocitrate dehydrogenase (IDH) gene mutation status of gliomas. Materials and Methods This retrospective study had institutional review board approval; written informed consent was obtained from all patients. Eighty-three patients with histopathologically proven glioma (World Health Organization [WHO] grade II-IV) were examined with quantitative blood oxygen level-dependent imaging and vascular architecture mapping...
December 13, 2016: Radiology
https://www.readbyqxmd.com/read/27939988/amtar2-functional-characterization-of-a-honeybee-tyramine-receptor-stimulating-adenylyl-cyclase-activity
#18
Tina Reim, Sabine Balfanz, Arnd Baumann, Wolfgang Blenau, Markus Thamm, Ricarda Scheiner
The biogenic monoamines norepinephrine and epinephrine regulate important physiological functions in vertebrates. Insects such as honeybees do not synthesize these neuroactive substances. Instead, they employ octopamine and tyramine for comparable physiological functions. These biogenic amines activate specific guanine nucleotide-binding (G) protein-coupled receptors (GPCRs). Based on pharmacological data obtained on heterologously expressed receptors, α- and β-adrenergic-like octopamine receptors are better activated by octopamine than by tyramine...
January 2017: Insect Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/27888608/efficacy-and-safety-of-combined-intraventricular-fibrinolysis-with-lumbar-drainage-for-prevention-of-permanent-shunt-dependency-after-intracerebral-hemorrhage-with-severe-ventricular-involvement-a-randomized-trial-and-individual-patient-data-meta-analysis
#19
Dimitre Staykov, Joji B Kuramatsu, Jürgen Bardutzky, Bastian Volbers, Stefan T Gerner, Stephan P Kloska, Arnd Doerfler, Stefan Schwab, Hagen B Huttner
OBJECTIVE: Intraventricular hemorrhage (IVH) is a negative prognostic factor in intracerebral hemorrhage (ICH) and is associated with permanent shunt dependency in a substantial proportion of patients post-ICH. IVH treatment by intraventricular fibrinolysis (IVF) was recently linked to reduced mortality rates in the CLEAR III study and IVF represents a safe and effective strategy to hasten clot resolution that may reduce shunt rates. Additionally, promising results from observational studies reported reductions in shunt dependency for a combined treatment approach of IVF plus lumbar drains (LDs)...
January 2017: Annals of Neurology
https://www.readbyqxmd.com/read/27879083/ustekinumab-in-der-therapie-der-pustulosis-palmoplantaris-eine-fallserie-mit-neun-patienten
#20
Valeska Buder, Katharina Herberger, Arnd Jacobi, Matthias Augustin, Marc Alexander Radtke
HINTERGRUND: Die Pustulosis palmoplantaris ist eine chronisch entzündliche Hauterkrankung, die mit bedeutenden Einschränkungen der Lebensqualität und der Belastbarkeit einhergeht. Aufgrund von Zulassungsbeschränkungen und einem häufig therapierefraktären Verlauf sind die Behandlungsmöglichkeiten limitiert. PATIENTEN UND METHODIK: Nach zuvor frustranen Therapien erhielten 9 Patienten mit Pustulosis palmoplantaris nach Ausschluss einer latenten Tuberkulose Ustekinumab (45 mg Ustekinumab bei < 100 kg Körpergewicht [KG], 90 mg Ustekinumab > 100 kg KG) in Woche 0, 4, 12 und 24...
November 2016: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
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