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https://www.readbyqxmd.com/read/29675026/multiplex-cytokine-analysis-of-aqueous-humor-in-juvenile-idiopathic-arthritis-associated-anterior-uveitis-with-or-without-secondary-glaucoma
#1
Dirk Bauer, Maren Kasper, Karoline Walscheid, Jörg M Koch, Philipp S Müther, Bernd Kirchhof, Arnd Heiligenhaus, Carsten Heinz
Patients with juvenile idiopathic arthritis often develop chronic anterior uveitis (JIAU). JIAU patients possess a particularly high risk for developing secondary glaucoma when inflammatory inactivity has been achieved. By using multiplex bead assay analysis, we assessed levels of pro- and anti-inflammatory cytokines, chemokines, or metalloproteinases in the aqueous humor (AH) of patients with clinically inactive JIAU with (JIAUwG) or without secondary glaucoma (JIAUwoG), or from patients with senile cataract as controls...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29668721/ultra-high-field-mri-of-human-hippocampi-morphological-and-multiparametric-differentiation-of-hippocampal-sclerosis-subtypes
#2
Clarissa Gillmann, Roland Coras, Karl Rössler, Arnd Doerfler, Michael Uder, Ingmar Blümcke, Tobias Bäuerle
The aim of the present study is to differentiate subtypes of hippocampal sclerosis (HS) using ex vivo ultra-high field magnetic resonance imaging (MRI). Included were 14 surgically resected hippocampi of patients with medically intractable temporal lobe epilepsy. The resected hippocampi were histologically categorized into subtypes of hippocampal sclerosis (HS type 1 (n = 10), HS type 2 (n = 2) and no-HS (n = 2)) and subsequently scanned on a preclinical 7T MRI acquiring T2-weighted morphology, relaxometry and diffusion tensor imaging...
2018: PloS One
https://www.readbyqxmd.com/read/29649840/-therapeutic-concepts-for-treatment-of-patients-with-non-infectious-uveitis-biologic-disease-modifying-antirheumatic-drugs
#3
Karoline Walscheid, Uwe Pleyer, Arnd Heiligenhaus
Biologic disease modifying antirheumatic drugs (bDMARDs) can be highly efficient in the treatment of various non-infectious uveitis entities. Currently, the TNF-α-inhibitor Adalimumab is the only in-label therapeutic option, whereas, all other bDMARDs need to be given as an off-label therapy. bDMARDs are indicated in diseases refractory to conventional synthetic DMARD therapy and/or systemic steroids, or in patients in whom treatment with those is not possible due to side effects. Therapeutic mechanisms currently employed are cytokine-specific (interferons, inhibition of TNF-α or of interleukin [IL]-1-, IL-6- or IL-17-signalling), inhibit T cell costimulation (CTLA-4 fusion protein), or act via depletion of B cells (anti-CD20)...
April 12, 2018: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29616603/snack-food-as-a-modulator-of-human-resting-state-functional-connectivity
#4
Andrea Mendez-Torrijos, Silke Kreitz, Claudiu Ivan, Laura Konerth, Julie Rösch, Monika Pischetsrieder, Gunther Moll, Oliver Kratz, Arnd Dörfler, Stefanie Horndasch, Andreas Hess
OBJECTIVE: To elucidate the mechanisms of how snack foods may induce non-homeostatic food intake, we used resting state functional magnetic resonance imaging (fMRI), as resting state networks can individually adapt to experience after short time exposures. In addition, we used graph theoretical analysis together with machine learning techniques (support vector machine) to identifying biomarkers that can categorize between high-caloric (potato chips) vs. low-caloric (zucchini) food stimulation...
April 4, 2018: CNS Spectrums
https://www.readbyqxmd.com/read/29607807/fitness-to-drive-after-sternotomy
#5
Arnd Afflerbach
No abstract text is available yet for this article.
March 16, 2018: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/29592918/consensus-based-recommendations-for-the-management-of-uveitis-associated-with-juvenile-idiopathic-arthritis-the-share-initiative
#6
Tamas Constantin, Ivan Foeldvari, Jordi Anton, Joke de Boer, Severine Czitrom-Guillaume, Clive Edelsten, Raz Gepstein, Arnd Heiligenhaus, Clarissa A Pilkington, Gabriele Simonini, Yosef Uziel, Sebastian J Vastert, Nico M Wulffraat, Anne-Mieke Haasnoot, Karoline Walscheid, Annamária Pálinkás, Reshma Pattani, Zoltán Györgyi, Richárd Kozma, Victor Boom, Andrea Ponyi, Angelo Ravelli, Athimalaipet V Ramanan
BACKGROUND: In 2012, a European initiative called S ingle Hub and Access point for pediatric Rheumatology in Europe (SHARE) was launched to optimise and disseminate diagnostic and management regimens in Europe for children and young adults with rheumatic diseases. Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease in children and uveitis is possibly its most devastating extra-articular manifestation. Evidence-based guidelines are sparse and management is mostly based on physicians' experience...
March 28, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29588831/analysis-of-the-expression-pattern-of-the-schizophrenia-risk-and-intellectual-disability-gene-tcf4-in-the-developing-and-adult-brain-suggests-a-role-in-development-and-plasticity-of-cortical-and-hippocampal-neurons
#7
Matthias Jung, Benjamin M Häberle, Tristan Tschaikowsky, Marie-Theres Wittmann, Elli-Anna Balta, Vivien-Charlott Stadler, Christiane Zweier, Arnd Dörfler, Christian Johannes Gloeckner, D Chichung Lie
Background: Haploinsufficiency of the class I bHLH transcription factor TCF4 causes Pitt-Hopkins syndrome (PTHS), a severe neurodevelopmental disorder, while common variants in the TCF4 gene have been identified as susceptibility factors for schizophrenia. It remains largely unknown, which brain regions are dependent on TCF4 for their development and function. Methods: We systematically analyzed the expression pattern of TCF4 in the developing and adult mouse brain...
2018: Molecular Autism
https://www.readbyqxmd.com/read/29579064/neural-processing-of-food-and-emotional-stimuli-in-adolescent-and-adult-anorexia-nervosa-patients
#8
Stefanie Horndasch, Julie Roesch, Clemens Forster, Arnd Dörfler, Silja Lindsiepe, Hartmut Heinrich, Holmer Graap, Gunther H Moll, Oliver Kratz
BACKGROUND: A constant preoccupation with food and restrictive eating are main symptoms of anorexia nervosa (AN). Imaging studies revealed aberrant neural activation patterns in brain regions processing hedonic and reward reactions as well as-potentially aversive-emotions. An imbalance between so called "bottom-up" and "top-down" control areas is discussed. The present study is focusing on neural processing of disease-specific food stimuli and emotional stimuli and its developmental course in adolescent and adult AN patients and could offer new insight into differential mechanisms underlying shorter or more chronic disease...
2018: PloS One
https://www.readbyqxmd.com/read/29575337/diurnal-periodicity-of-assimilate-transport-shapes-resource-allocation-and-whole-plant-carbon-balance
#9
Katrin Brauner, Benjamin Birami, Horst A Brauner, Arnd G Heyer
Whole plant carbon balance comprises diurnal fluctuations of photosynthetic carbon gain and respiratory losses, as well as partitioning of assimilates between phototrophic and heterotrophic organs. Because it is difficult to access, the root system is frequently neglected in growth models, or its metabolism is rated based on generalizations from other organs. Here, whole-plant cuvettes were used for investigating total plant carbon exchange with the environment over full diurnal cycles. Dynamics of primary metabolism and diurnally resolved phloem exudation profiles, as proxy of assimilate transport, were combined to obtain a full picture of resource allocation...
March 25, 2018: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/29553284/quantitative-t2-mapping-shows-increased-degeneration-in-adjacent-intervertebral-discs-following-kyphoplasty
#10
Milena L Pachowsky, Arnd Kleyer, Lisa Wagner, Andreas Langenbach, David Simon, Rolf Janka, Matthias May, Goetz H Welsch
Objective A minimally invasive treatment of osteoporotic and nonosteoporotic thoracic and lumbar spine fractures is cement augmentation (kyphoplasty). Little is known about the impact on adjacent intervertebral discs. A quantitative magnetic resonance imaging (MRI) approach in addition to morphological MRI is desirable to evaluate changes in the intervertebral disc. Our study aims to evaluate the feasibility of T2 mapping for the detection of subtle changes in the intervertebral discs in spines after kyphoplasty...
March 1, 2018: Cartilage
https://www.readbyqxmd.com/read/29530504/quantifying-spatial-and-temporal-variations-of-the-cell-membrane-ultra-structure-by-bimfcs
#11
REVIEW
Weixiang Jin, M Fethullah Simsek, Arnd Pralle
It has been long recognized that the cell membrane is heterogeneous on scales ranging from a couple of molecules to micrometers in size and hence diffusiong of receptors is length scale dependent. This heterogeneity modulates many cell-membrane-associated processes requiring transient spatiotemporal separation of components. The transient increase in local concentration of interacting signal components enables robust signaling in an otherwise thermally noisy system. Understanding how lipids and proteins self-organize and interact with the cell cortex requires quantifying the motion of the components...
March 9, 2018: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/29529259/management-of-therapeutic-anticoagulation-in-patients-with-intracerebral-haemorrhage-and-mechanical-heart-valves
#12
Joji B Kuramatsu, Jochen A Sembill, Stefan T Gerner, Maximilian I Sprügel, Manuel Hagen, Sebastian S Roeder, Matthias Endres, Karl Georg Haeusler, Jan Sobesky, Johannes Schurig, Sarah Zweynert, Miriam Bauer, Peter Vajkoczy, Peter A Ringleb, Jan Purrucker, Timolaos Rizos, Jens Volkmann, Wolfgang Müllges, Peter Kraft, Anna-Lena Schubert, Frank Erbguth, Martin Nueckel, Peter D Schellinger, Jörg Glahn, Ulrich J Knappe, Gereon R Fink, Christian Dohmen, Henning Stetefeld, Anna Lena Fisse, Jens Minnerup, Georg Hagemann, Florian Rakers, Heinz Reichmann, Hauke Schneider, Sigrid Wöpking, Albert Christian Ludolph, Sebastian Stösser, Hermann Neugebauer, Joachim Röther, Peter Michels, Michael Schwarz, Gernot Reimann, Hansjörg Bäzner, Henning Schwert, Joseph Claßen, Dominik Michalski, Armin Grau, Frederick Palm, Christian Urbanek, Johannes C Wöhrle, Fahid Alshammari, Markus Horn, Dirk Bahner, Otto W Witte, Albrecht Günther, Gerhard F Hamann, Hannes Lücking, Arnd Dörfler, Stephan Achenbach, Stefan Schwab, Hagen B Huttner
Aims: Evidence is lacking regarding acute anticoagulation management in patients after intracerebral haemorrhage (ICH) with implanted mechanical heart valves (MHVs). Our objective was to investigate anticoagulation reversal and resumption strategies by evaluating incidences of haemorrhagic and thromboembolic complications, thereby defining an optimal time-window when to restart therapeutic anticoagulation (TA) in patients with MHV and ICH. Methods and results: We pooled individual patient-data (n = 2504) from a nationwide multicentre cohort-study (RETRACE, conducted at 22 German centres) and eventually identified MHV-patients (n = 137) with anticoagulation-associated ICH for outcome analyses...
February 24, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29513936/an-amino-acid-motif-in-hla-dr%C3%AE-1-distinguishes-patients-with-uveitis-in-juvenile-idiopathic-arthritis
#13
Anne-Mieke J W Haasnoot, Marco W Schilham, Sylvia Kamphuis, Petra C E Hissink Muller, Arnd Heiligenhaus, Dirk Foell, Kirsten Minden, Roel A Ophoff, Timothy R D J Radstake, Anneke I Den Hollander, Tjitske H C M Reinards, Sanne Hiddingh, Nicoline E Schalij-Delfos, Esther P A H Hoppenreijs, Marion A J van Rossum, Carine Wouters, Rotraud K Saurenmann, J Merlijn van den Berg, Nico M Wulffraat, Rebecca Ten Cate, Joke H de Boer, Sara L Pulit, Jonas J W Kuiper
OBJECTIVES: Uveitis is a visually-debilitating disorder that affects up to 30% of children with the most common forms of juvenile idiopathic arthritis (JIA). The disease mechanisms predisposing only a subgroup of children to uveitis are unknown. To identify genetic susceptibility loci for uveitis in JIA, we conducted a genome-wide association study totalling 522 JIA cases. METHODS: We genotyped two cohorts of JIA patients with ophthalmological follow-up and then imputed the data using a genome-wide imputation reference panel, and an HLA-specific reference panel used for imputing amino acids and HLA types in the major histocompatibility complex (MHC)...
March 7, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29507175/wavenumber-selection-via-spatial-parameter-jump
#14
Arnd Scheel, Jasper Weinburd
The Swift-Hohenberg equation describes an instability which forms finite-wavenumber patterns near onset. We study this equation posed with a spatial inhomogeneity; a jump-type parameter that renders the zero solution stable for x <0 and unstable for x >0. Using normal forms and spatial dynamics, we prove the existence of a family of steady-state solutions that represent a transition in space from a homogeneous state to a striped pattern state. The wavenumbers of these stripes are contained in a narrow band whose width grows linearly with the size of the jump...
April 13, 2018: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/29479201/ten-year-experience-of-fetal-alcohol-spectrum-disorder-diagnostic-and-resource-challenges-in-indigenous-children
#15
Anna Banerji, Chandrakant Shah
Background: Although fetal alcohol spectrum disorder (FASD) can have a disproportionate impact in some Indigenous communities, there is a paucity of literature on its epidemiology. Objective: To characterize the epidemiology of Indigenous individuals under the age of 18 years who were diagnosed with FASD at Anishnawbe Health Toronto over a 10-year period. Methods: Children who were assessed at Anishnawbe Health Toronto from 2002 to 2012 and met the 2005 criteria for FASD were included...
June 2017: Paediatrics & Child Health
https://www.readbyqxmd.com/read/29475856/biomechanical-properties-of-bone-are-impaired-in-patients-with-acpa-positive-rheumatoid-arthritis-and-associated-with-the-occurrence-of-fractures
#16
Fabian Stemmler, David Simon, Anna-Maria Liphardt, Matthias Englbrecht, Juergen Rech, Axel J Hueber, Klaus Engelke, Georg Schett, Arnd Kleyer
OBJECTIVES: Bone loss is a well-established consequence of rheumatoid arthritis (RA). To date, bone disease in RA is exclusively characterised by bone density measurements, while the functional properties of bone in RA are undefined. This study aimed to define the impact of RA on the functional properties of bone, such as failure load and stiffness. METHODS: Micro-finite element analysis (µFEA) was carried out to measure failure load and stiffness of bone based on high-resolution peripheral quantitative CT data from the distal radius of anti-citrullinated protein antibody (ACPA)-positive RA (RA+), ACPA-negative RA (RA-) and healthy controls (HC)...
February 23, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29467337/nitric-oxide-sensitive-guanylyl-cyclase-stimulation-improves-experimental-heart-failure-with-preserved-ejection-fraction
#17
Nicola Wilck, Lajos Markó, András Balogh, Kristin Kräker, Florian Herse, Hendrik Bartolomaeus, István A Szijártó, Maik Gollasch, Nadine Reichhart, Olaf Strauss, Arnd Heuser, Damian Brockschnieder, Axel Kretschmer, Ralf Lesche, Florian Sohler, Johannes-Peter Stasch, Peter Sandner, Friedrich C Luft, Dominik N Müller, Ralf Dechend, Nadine Haase
Heart failure with preserved ejection fraction (HFpEF) can arise from cardiac and vascular remodeling processes following long-lasting hypertension. Efficacy of common HF therapeutics is unsatisfactory in HFpEF. Evidence suggests that stimulators of the nitric oxide-sensitive soluble guanylyl cyclase (NOsGC) could be of use here. We aimed to characterize the complex cardiovascular effects of NOsGC stimulation using NO-independent stimulator BAY 41-8543 in a double-transgenic rat (dTGR) model of HFpEF. We show a drastically improved survival rate of treated dTGR...
February 22, 2018: JCI Insight
https://www.readbyqxmd.com/read/29411097/-big-data-in-imaging
#18
REVIEW
Philipp Sewerin, Benedikt Ostendorf, Axel J Hueber, Arnd Kleyer
Until now, most major medical advancements have been achieved through hypothesis-driven research within the scope of clinical trials. However, due to a multitude of variables, only a certain number of research questions could be addressed during a single study, thus rendering these studies expensive and time consuming. Big data acquisition enables a new data-based approach in which large volumes of data can be used to investigate all variables, thus opening new horizons. Due to universal digitalization of the data as well as ever-improving hard- and software solutions, imaging would appear to be predestined for such analyses...
February 6, 2018: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/29395573/increased-levels-of-lipocalin-2-in-palmoplantar-pustular-psoriasis
#19
Kerstin Wolk, Yvonne Frambach, Arnd Jacobi, Dagmar Wilsmann-Theis, Sandra Phillipp, Ellen Witte-Händel, Jörg Wenzel, Rotraut Mössner, Robert Sabat
BACKGROUND: Palmoplantar pustular psoriasis (PPP) is a recalcitrant chronic skin disease affecting the palms and soles. OBJECTIVE: To identify and characterize pathogenetic players in PPP. METHODS: Clinical and anamnestic data as well as skin and blood samples of 60 PPP patients were collected. Healthy participants served as controls. Analysis of patient samples and cultured primary skin cells was performed by ELISA, qRT-PCR, and immunohistochemistry...
January 11, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29395308/a-collagen-fibrin-patch-for-the-prevention-of-symptomatic-lymphoceles-after-pelvic-lymphadenectomy-in-women-with-gynecologic-malignancies-a-randomized-clinical-trial
#20
Christoph Grimm, Stephan Polterauer, Samir Helmy-Bader, Michal Zikan, David Cibula, Florian Heitz, Philipp Harter, Arnd Giese, Alexander Reinthaller, Clemens Tempfer
OBJECTIVE: To evaluate the efficacy of a collagen-fibrin patch for the prevention of symptomatic lymphoceles after pelvic lymphadenectomy in women with gynecologic malignancies. METHODS: In a multicenter, randomized, clinical trial, 164 women with pelvic lymphadenectomy were allocated either to bilateral pelvic application of two collagen-fibrin patches or no intervention. Main outcome was efficacy, defined as reduction of symptomatic lymphocele rate diagnosed within four weeks after surgery...
January 30, 2018: Gynecologic Oncology
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