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https://www.readbyqxmd.com/read/28805672/challenges-in-estimating-vaccine-coverage-in-refugee-and-displaced-populations-results-from-household-surveys-in-jordan-and-lebanon
#1
Timothy Roberton, William Weiss, Shannon Doocy
Ensuring the sustained immunization of displaced persons is a key objective in humanitarian emergencies. Typically, humanitarian actors measure coverage of single vaccines following an immunization campaign; few measure routine coverage of all vaccines. We undertook household surveys of Syrian refugees in Jordan and Lebanon, outside of camps, using a mix of random and respondent-driven sampling, to measure coverage of all vaccinations included in the host country's vaccine schedule. We analyzed the results with a critical eye to data limitations and implications for similar studies...
August 12, 2017: Vaccines
https://www.readbyqxmd.com/read/28796161/comparison-of-liver-detargeting-strategies-for-systemic-therapy-with-oncolytic-adenovirus-serotype-5
#2
Tien V Nguyen, Mary E Barry, Mallory A Turner, Catherine M Crosby, Miguel A Trujillo, John C Morris, Michael A Barry
Oncolytic viruses would ideally be of use for systemic therapy to treat disseminated cancer. To do this safely, this may require multiple layers of cancer specificity. The pharmacology and specificity of oncolytic adenoviruses can be modified by (1) physical retargeting, (2) physical detargeting, (3) chemical shielding, or (4) by modifying the ability of viral early gene products to selectively activate in cancer versus normal cells. We explored the utility of these approaches with oncolytic adenovirus serotype 5 (Ad5) in immunocompetent Syrian hamsters bearing subcutaneous HaK tumors...
August 10, 2017: Biomedicines
https://www.readbyqxmd.com/read/28791243/an-overview-of-the-health-status-of-syrian-refugee-children-in-a-tertiary-hospital-in-turkey
#3
Ibrahim Hakan Bucak, Habip Almis, Samet Benli, Mehmet Turgut
OBJECTIVE: Migration is a problem affecting all family members, but particularly children. Child refugees are the highest risk group for the health systems of receiving countries. We investigated the health of 104 Syrian child refugees presenting to a tertiary hospital in Turkey. SETTINGS AND DESIGN: A retrospective study was conducted in the pediatric clinic. MATERIALS AND METHODS: The medical files of Syrian refugee children (0-18 years) presenting to Adiyaman University Hospital, Pediatric Clinic between 01 and 30 November 2015, were investigated...
July 2017: Avicenna Journal of Medicine
https://www.readbyqxmd.com/read/28791242/an-online-academic-writing-and-publishing-skills-course-help-syrians-find-their-voice
#4
Ammar Sabouni, Abdelkader Chaar, Yamama Bdaiwi, Abdulrahman Masrani, Heba Abolaban, Fares Alahdab, Belal Firwana, Ahmad Al-Moujahed
PURPOSE: A group of Arab-American physicians and researchers in the United States organized a blended online course in academic writing and publishing in medicine targeting medical students and physicians in war-torn Syria. This was an effort to address one of the reasons behind the poor quantity and quality of scientific research papers in Syria and the Arab region. In this paper, we report on the design, conduct, and outcome of this course and attempt to evaluate its effectiveness. METHODS: The educational intervention was a 2-month blended online course...
July 2017: Avicenna Journal of Medicine
https://www.readbyqxmd.com/read/28780414/chitosan-coated-pluronicf127-micelles-for-effective-delivery-of-amphotericin-b-in-experimental-visceral-leishmaniasis
#5
Pankaj K Singh, Vivek K Pawar, Anil K Jaiswal, Yuvraj Singh, Cheruvu Hanumanth Srikanth, Mohini Chaurasia, Himangsu K Bora, Kavit Raval, Jaya Gopal Meher, Jiaur R Gayen, Anuradha Dube, Manish K Chourasia
The goal of study was to develop micellar formulation of Amphotericin B (AmB) to improve its antileishmanial efficacy. AmB loaded pluronic F127 (PF 127) micelles were developed and coated with chitosan (Cs-PF-AmB-M) to accord immunoadjuvant and macrophage targeting properties. Hemolysis and cytotoxicity studies demonstrated that Cs-PF-AmB-M was 7.93 fold (at 20μg/ml AmB concentration) and 9.35 fold less hemolytic and cytotoxic, respectively in comparison to AmB suspension. Flow cytometry studies indicated that Cs-PF-FITC-M was 21...
August 2, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28764732/in-vitro-and-in-vivo-activity-of-r-and-s-praziquantel-enantiomers-and-the-main-human-metabolite-trans-4-hydroxy-praziquantel-against-schistosoma-haematobium
#6
Jana Kovač, Mireille Vargas, Jennifer Keiser
BACKGROUND: Praziquantel (PZQ) is the mainstay of schistosomiasis control and has been successfully used for decades. However, its mechanism of action is not fully understood. While the majority of studies have been conducted on Schistosoma mansoni, it is not known which enantiomer, R- or S-praziquantel (R-/S-PZQ), is responsible for the activity on Schistosoma haematobium. METHODS: In vitro and in vivo studies were conducted to evaluate the activity of R- and S-PZQ, racemic PZQ and the main human metabolite, namely trans-4-OH-PZQ, on S...
August 1, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28758614/the-ongoing-syrian-arab-republic-health-care-crisis
#7
Steven J Phillips
Prior to the Syrian civil war, access and delivery of health care and health care information over the past 4 decades had steadily improved. The life expectancy of the average Syrian in 2012 was 75.7 years, compared to 56 years in 1970. As a result of the civil war, this trend has reversed, with the life expectancy reduced by 20 years from the 2012 level. The Syrian government and its allies have specifically targeted the health care infrastructure not under government control. (Disaster Med Public Health Preparedness...
July 31, 2017: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/28757595/early-marriage-and-barriers-to-contraception-among-syrian-refugee-women-in-lebanon-a-qualitative-study
#8
Zeinab Cherri, Julita Gil Cuesta, Jose M Rodriguez-Llanes, Debarati Guha-Sapir
The Syrian conflict has displaced five million individuals outside their country with Lebanon hosting the largest numbers per capita. Around 24% of Syrian refugees fleeing to Lebanon are women of reproductive age (15-49). Yet, a better understanding of the sexual and reproductive health needs of Syrian refugee women in Lebanon is required to improve provided services. Eleven focus group discussions were conducted in four regions of Lebanon with 108 Syrian refugee women of reproductive age. Thematic analysis was used to examine the data...
July 25, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28748250/-disseminated-osteolytic-lesions-in-a-28-year-old-refugee
#9
T Karrasch, H D Walmrath, M Kampschulte, D Steiner, W Seeger, W Padberg, U Sibelius, S Gattenlöhner, A Schäffler
A 28-year-old Syrian refugee presented with right-sided knee pain and progressive deterioration of the general condition over the past months. Laboratory diagnostics revealed severe hypercalcemia due to primary hyperparathyroidism, and computed tomography (CT) scanning demonstrated disseminated osteolytic lesions throughout the skeleton. Histologically, these lesions were characterized by multinuclear giant cells (defining these lesions as so-called brown tumors). Finally, surgical removal of a jugular mass allowed the histopathologic diagnosis of a sporadic parathyroid carcinoma...
July 26, 2017: Der Internist
https://www.readbyqxmd.com/read/28738869/maternal-depression-in-syrian-refugee-women-recently-moved-to-canada-a-preliminary-study
#10
Asma Ahmed, Angela Bowen, Cindy Xin Feng
BACKGROUND: Refugee women are almost five times more likely to develop postpartum depression than Canadian-born women. This can be attributed to various difficulties they faced before coming to Canada as well as during resettlement. Moreover, refugee women usually face many obstacles when accessing health services, including language and cultural barriers, as well as unique help-seeking behaviors that are influenced by various cultural and practical factors. There has been a recent, rapid influx of Syrian refugees to Canada, and many of them are childbearing women...
July 24, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28733913/social-identity-continuity-and-mental-health-among-syrian-refugees-in-turkey
#11
Anouk Smeekes, Maykel Verkuyten, Elif Çelebi, Ceren Acartürk, Samed Onkun
PURPOSE: Building upon social psychological work on social identity and mental health, this study among Syrian refugees in Turkey examined the importance of multiple group memberships and identity continuity for mental health and well-being. METHOD: A survey study was conducted among the very difficult to reach population of Syrian refugees (N = 361). With path analysis in AMOS the associations were examined between multiple group memberships, social identity continuity and mental health and psychological well-being...
July 21, 2017: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/28732567/curcumin-3-4-dichloro-phenyl-pyrazole-cdpp-overcomes-curcumin-s-low-bioavailability-inhibits-adipogenesis-and-ameliorates-dyslipidemia-by-activating-reverse-cholesterol-transport
#12
Abhishek Gupta, Vinay Kumar Singh, Durgesh Kumar, Pragya Yadav, Santosh Kumar, Muheeb Beg, Kripa Shankar, Salil Varshney, Sujith Rajan, Ankita Srivastava, Rakhi Choudhary, Vishal M Balaramnavar, Rabi Bhatta, Narender Tadigoppula, Anil Nilkanth Gaikwad
BACKGROUND: Adipocyte dysfunction, obesity and associated metabolic disorders are of prime healthcare concern worldwide. Among available medications, natural products and inspired molecules hold 40% space in clinically prescribed medicines. In queue, this study overcomes the drawback of curcumin's low bioavailability with potent anti-adipogenic and anti-dyslipidemic activity. METHODS: To evaluate the role of CDPP on adipocyte differentiation, 3T3-L1 adipocytes were used as an in-vitro model...
August 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28725259/cardiovascular-disease-risk-and-prevention-amongst-syrian-refugees-mixed-methods-study-of-m%C3%A3-decins-sans-fronti%C3%A3-res-programme-in-jordan
#13
Dylan R J Collins, Kiran Jobanputra, Thomas Frost, Shoaib Muhammed, Alison Ward, Abed Alrazzaq Shafei, Taissir Fardous, Sadeq Gabashneh, Carl Heneghan
BACKGROUND: The growing burden of non-communicable diseases (NCDs) presented new challenges for medical humanitarian aid and little was known about primary health care approaches for these diseases in humanitarian response. We aimed to evaluate Médecins Sans Frontières (MSF's) use of total CVD risk based prevention strategies amongst Syrian refugees in northern Jordan to identify opportunities to improve total CVD risk based guidance for humanitarian settings. METHODS: We evaluated CVD risk assessment and management in two outpatient NCD clinics in the Irbid governorate of Jordan using a mixed methods design with qualitative and quantitative strands of equal priority, integrated during data collection and interpretation...
2017: Conflict and Health
https://www.readbyqxmd.com/read/28720037/emergency-department-visits-of-syrian-refugees-and-the-cost-of-their-healthcare
#14
Umut Gulacti, Ugur Lok, Haci Polat
The aim of this study was to evaluate the demographic and clinical characteristics of Emergency Department (ED) visits made by Syrian refugees and to assess the cost of their healthcare. This retrospective study was conducted in adult Syrians who visited the ED of Adiyaman University Training and Research Hospital, Adiyaman Province, Turkey, between 01 January and 31 December 2015. We evaluated 10,529 Syrian refugees who visited the ED, of whom 9,842 were included in the study. The number of ED visits significantly increased in 2015 compared with 2010; the increase in the proportion of total ED visits was 8% (n = 11,275, dif: 8%, CI 95%: 7...
July 18, 2017: Pathogens and Global Health
https://www.readbyqxmd.com/read/28715114/a-rare-case-of-obstructive-duodenal-phytobezoar-caused-by-two-lipomas
#15
Eunae Cho, Chung Hwan Jun, Eun Kyu Park, Chang Hwan Park, Hyun Soo Kim, Sung Kyu Choi, Jong Sun Rew
The word 'bezoar' comes from either the Persian word 'padzahr' or the Arabic word 'badzehr' both of which denote 'antidote.' This word meant a hard stone found in the stomach of the Syrian goat and believed to prevent poisoning(1) .
July 17, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28711792/regulation-of-proline-biosynthesis-and-resistance-to-drought-stress-in-two-barley-hordeum-vulgare-l-genotypes-of-different-origin
#16
Hanna Bandurska, Justyna Niedziela, Małgorzata Pietrowska-Borek, Katarzyna Nuc, Tamara Chadzinikolau, Dominika Radzikowska
Drought is considered the main abiotic stress factor that inhibits growth of crop plants (including barley), limiting yield in many regions worldwide. Predicted climate changes show that in future the frequency and intensity of drought events will rise, so crops that are resistant to this stress are in demand. One of the adaptive metabolic responses to drought is the accumulation of proline. The aim of this study was to examine the effect of 10-day drought on tissue dehydration and proline biosynthesis in leaves as well as in roots of barley genotypes of different origin: the Syrian breeding line Cam/B1/CI and the German cultivar Maresi...
July 8, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28707099/maternal-health-care-utilization-among-syrian-refugees-in-lebanon-and-jordan
#17
Hannah Tappis, Emily Lyles, Ann Burton, Shannon Doocy
Purpose The influx of Syrian refugees into Jordan and Lebanon over the last 5 years presents an immense burden to national health systems. This study was undertaken to assess utilization of maternal health services among Syrian refugees in both countries. Description A cross-sectional survey of Syrian refugees living in urban and rural (non-camp) settings was conducted using a two-stage cluster survey design with probability proportional to size sampling in 2014-2015. Eighty-six percent of surveyed households in Lebanon and 88% of surveyed households in Jordan included women with a live birth in the last year...
July 13, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/28704385/immunoprotective-properties-of-recombinant-liga-and-ligb-in-a-hamster-model-of-acute-leptospirosis
#18
Karen V Evangelista, Kristel Lourdault, James Matsunaga, David A Haake
Leptospirosis is the most widespread zoonosis and is considered a major public health problem worldwide. Currently, there is no widely available vaccine against leptospirosis for use in humans. A purified, recombinant subunit vaccine that includes the last six immunoglobulin-like (Ig-like) domains of the leptospiral protein LigA (LigA7'-13) protects against lethal infection but not renal colonization after challenge by Leptospira interrogans. In this study, we examined whether the addition of the first seven Ig-like domains of LigB (LigB0-7) to LigA7'-13, can enhance immune protection and confer sterilizing immunity in the Golden Syrian hamster model of acute leptospirosis...
2017: PloS One
https://www.readbyqxmd.com/read/28702132/measuring-levels-of-osteopontin-as-potential-biomarker-for-hepatocellular-carcinoma-in-syrian-patients
#19
Sara Al-Zoubi, Ahmad Wassouf, Almoutassem Billah Zetoune
AIM: This study aims to evaluate plasma osteopontin (OPN) levels as a potential biomarker for hepatocellular carcinoma (HCC). BACKGROUND: Osteopontin (OPN) is a secreted glycoprotein that is associated with tumorigenesis and metastasis. METHODS: We measured plasma levels of OPN in 26 HCC patients, 27 patients with chronic liver diseases (CLD), and 15 healthy control individuals using a standardized ELISA kit. RESULTS: The mean plasma OPN level was significantly higher in the HCC group than the CLD group or the normal control group (p-value =0...
2017: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/28700976/the-protective-effect-of-coptisine-on-experimental-atherosclerosis-apoe-mice-is-mediated-by-mapk-nf-%C3%AE%C2%BAb-dependent-pathway
#20
Min Feng, Shu-Zhen Kong, Zhen-Xu Wang, Kai He, Zong-Yao Zou, Yin-Ran Hu, Hang Ma, Xue-Gang Li, Xiao-Li Ye
Coptisine is one of main bioactive compounds extracted from the traditional Chinese herbal medicine Rhizoma Coptidis. It is reported that coptisine can attenuate obesity-related inflammation and oxidant damage in Syrian golden hamsters. Therefore,coptisine may exhibit beneficial effects for the treatment of atherosclerosis (AS) due to its hypolipidemic and anti-inflammation activities. The present study investigated the anti-atherosclerotic and anti-inflammatory properties of coptisine using apoE(-/-) mice as AS model...
September 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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