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https://www.readbyqxmd.com/read/28918031/anti-adenoviral-artificial-micrornas-expressed-from-aav9-vectors-inhibit-human-adenovirus-infection-in-immunosuppressed-syrian-hamsters
#1
Katrin Schaar, Anja Geisler, Milena Kraus, Sandra Pinkert, Markian Pryshliak, Jacqueline F Spencer, Ann E Tollefson, Baoling Ying, Jens Kurreck, William S Wold, Robert Klopfleisch, Karoly Toth, Henry Fechner
Infections of immunocompromised patients with human adenoviruses (hAd) can develop into life-threatening conditions, whereas drugs with anti-adenoviral efficiency are not clinically approved and have limited efficacy. Small double-stranded RNAs that induce RNAi represent a new class of promising anti-adenoviral therapeutics. However, as yet, their efficiency to treat hAd5 infections has only been investigated in vitro. In this study, we analyzed artificial microRNAs (amiRs) delivered by self-complementary adeno-associated virus (scAAV) vectors for treatment of hAd5 infections in immunosuppressed Syrian hamsters...
September 15, 2017: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/28899241/the-syrian-refugee-crisis-what-nurses-need-to-know
#2
Esmihan Almontaser, Steven L Baumann
The civil war in Syria that began in 2011 has displaced millions of Syrians of all ages. While the number that have arrived in the United States is small in comparison to many other countries, it is important that nurses and other healthcare workers here understand that many of them have faced considerable trauma and endured stresses. Most of them are Muslims. Muslims in the United States and elsewhere represent a heterogeneous group of people with a long intellectual and cultural history. Islamic cultural patterns do pose unique barriers to a primarily Anglo-Saxon medical system that medical practitioners need to consider in order to avoid misunderstanding and provide culturally sensitive care...
April 2017: Nursing Science Quarterly
https://www.readbyqxmd.com/read/28895503/needs-assessment-with-elder-syrian-refugees-in-lebanon-implications-for-services-and-interventions
#3
Zeina Chemali, Christina P C Borba, Kelsey Johnson, Sama Khair, Gregory L Fricchione
Currently, over 1 million Syrian and Palestinian refugees have fled Syria to take refuge in Lebanon. Among this vulnerable population, elder refugees warrant particular concern, as they shoulder a host of additional health and safety issues that require additional resources. However, the specific needs of elder refugees are often overlooked, especially during times of crisis. Our study used a semi-structured interview to survey the needs of elder refugees and understand their perceived support from Lebanese fieldworkers...
September 12, 2017: Global Public Health
https://www.readbyqxmd.com/read/28890157/the-cumulative-burden-of-surviving-childhood-cancer-an-initial-report-from-the-st-jude-lifetime-cohort-study-sjlife
#4
Nickhill Bhakta, Qi Liu, Kirsten K Ness, Malek Baassiri, Hesham Eissa, Frederick Yeo, Wassim Chemaitilly, Matthew J Ehrhardt, Johnnie Bass, Michael W Bishop, Kyla Shelton, Lu Lu, Sujuan Huang, Zhenghong Li, Eric Caron, Jennifer Lanctot, Carrie Howell, Timothy Folse, Vijaya Joshi, Daniel M Green, Daniel A Mulrooney, Gregory T Armstrong, Kevin R Krull, Tara M Brinkman, Raja B Khan, Deo K Srivastava, Melissa M Hudson, Yutaka Yasui, Leslie L Robison
BACKGROUND: Survivors of childhood cancer develop early and severe chronic health conditions (CHCs). A quantitative landscape of morbidity of survivors, however, has not been described. We aimed to describe the cumulative burden of curative cancer therapy in a clinically assessed ageing population of long-term survivors of childhood cancer. METHODS: The St Jude Lifetime Cohort Study (SJLIFE) retrospectively collected data on CHCs in all patients treated for childhood cancer at the St Jude Children's Research Hospital who survived 10 years or longer from initial diagnosis and were 18 years or older as of June 30, 2015...
September 7, 2017: Lancet
https://www.readbyqxmd.com/read/28889158/detection-and-identification-of-cutaneous-leishmaniasis-isolates-by-culture-polymerase-chain-reaction-and-sequence-analyses-in-syrian-and-central-anatolia-patients
#5
Yunus E Beyhan, Mehmet Karakus, Alper Karagoz, Mesut Mungan, Aysegul T Ozkan, Murat Hokelek
To characterize the cutaneous leishmaniasis (CL) isolates of Syrian and Central Anatolia patients at species levels. Methods: Skin scrapings of 3 patients (2 Syrian, 1 Turkish) were taken and examined by direct examination, culture in Novy-MacNeal-Nicole (NNN) medium, internal transcribed spacer polymerase chain reaction and sequence analysis (PCR). Results:According to microscopic examination, culture and PCR methods, 3 samples were detected positive. The sequencing results of all isolates in the study were identified as Leishmania tropica...
September 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/28886038/diagnoses-infections-and-injuries-in-northern-syrian-children-during-the-civil-war-a-cross-sectional-study
#6
Gerlant van Berlaer, Abdallah Mohamed Elsafti, Mohammad Al Safadi, Saad Souhil Saeed, Ronald Buyl, Michel Debacker, Atef Redwan, Ives Hubloue
BACKGROUND: The civil war in Syria including the deliberate targeting of healthcare services resulted in a complex humanitarian emergency, seriously affecting children's health. The objectives of this study are to document diagnoses and disease categories in Northern Syrian children after four years of conflict, and to document infectious diseases and injuries in this vulnerable population. METHODS: In a prospective cross-sectional observational sample study conducted in May 2015, healthcare workers registered demographics, comorbidities, and diagnoses (categorised according to the International Classification of Diseases version 10) in children visited at home and in internally displaced persons camps in four Syrian governorates...
2017: PloS One
https://www.readbyqxmd.com/read/28882952/comparing-the-organs-and-vasculature-of-the-head-and-neck-in-five-murine-species
#7
Min Jae Kim, Yoo Yeon Kim, Janet Ren Chao, Hae Sang Park, Jiwon Chang, Dawoon Oh, Jae Jun Lee, Tae Chun Kang, Jun-Gyo Suh, Jun Ho Lee
BACKGROUND/AIM: The purpose of the present study was to delineate the cervical and facial vascular and associated anatomy in five murine species, and compare them for optimal use in research studies focused on understanding the pathology and treatment of diseases in humans. MATERIALS AND METHODS: The specific adult male animals examined were mice (C57BL/6J), rats (F344), mongolian gerbils (Merionesunguiculatus), hamsters (Syrian), and guinea pigs (Hartley). To stain the vasculature and organs, of the face and neck, each animal was systemically perfused using the vital stain, Trypan Blue...
September 2017: In Vivo
https://www.readbyqxmd.com/read/28875164/increasing-drought-in-jordan-climate-change-and-cascading-syrian-land-use-impacts-on-reducing-transboundary-flow
#8
Deepthi Rajsekhar, Steven M Gorelick
In countries where severe drought is an anticipated effect of climate change and in those that heavily depend on upstream nations for fresh water, the effect of drier conditions and consequent changes in the transboundary streamflow regime induced by anthropogenic interventions and disasters leads to uncertainty in regional water security. As a case in point, we analyze Jordan's surface water resources and agricultural water demand through 2100, considering the combined impacts of climate change and land-use change driven by the Syrian conflict...
August 2017: Science Advances
https://www.readbyqxmd.com/read/28874381/efficacy-of-a-new-recrystallized-enrofloxacin-hydrochloride-dihydrate-against-leptospirosis-in-a-hamster-model
#9
Alma Carrascosa, Lilia Gutierrez, Alejandro De la Peña, Irma E Candanosa, Graciela Tapia, Hector Sumano
A trial on Syrian hamsters (Mesocricetus auratus) infected with Leptospira interrogans serovar Canicola was established to compare treatment efficacies of daily IM injections of either 10 mg/kg of Baytril® 5% or the same dose of enrofloxacin dihydrate-hydrochloride (enro-C). Hamsters were experimentally infected via oral submucosa with 400 microorganisms/animal, in a sequential time-schedule to align initial treatment day as follows: group BE24 treated with Baytril® daily for 7 days after 24 of infection; group enro-C24 treated with enro-C as in group BE24; group BE74 treated also with Baytril®, but starting 72 h after infection; group enro-C74 treated as group BE74 but injecting enro-C...
September 5, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28857014/implementation-of-a-sensemaker%C3%A2-research-project-among-syrian-refugees-in-lebanon
#10
Nour Bakhache, Saja Michael, Sophie Roupetz, Stephanie Garbern, Harveen Bergquist, Colleen Davison, Susan Bartels
The Syrian conflict has displaced over 1.2 million Syrians into Lebanon. As a result of displacement, some Syrian families are turning to child marriage as a coping mechanism. The prevalence of early marriage has reportedly increased and the average age of marriage decreased during the crisis. The aim of the project was to understand the underlying factors contributing to child marriage among Syrian refugees in Lebanon using Cognitive Edge's SenseMaker®. This manuscript explores the process of implementing this novel research tool in a humanitarian setting...
2017: Global Health Action
https://www.readbyqxmd.com/read/28854794/cross-species-hybridization-of-foot-and-mouth-disease-virus-infected-bhk-21-cells-using-human-and-mouse-oligonucleotide-microarrays
#11
H Zhang, Q Wang, L Han, C Zheng, C H Shen
Foot-and-mouth disease virus (FMDV) has a dual capacity to induce either acute or persistent infection in host animals. Establishment of an in vitro cell model of FMDV persistent infection facilitates the study of the mechanism underlying this type of infection. In this study, we analyzed gene expression profiles of both acute and persistent infections using cross-species microarrays. Our data suggest that human microarrays are more efficient than mouse microarrays in hybridization with cDNA from BHK-21 cells although the mouse is closer to the Syrian hamster in taxonomy...
2017: Acta Virologica
https://www.readbyqxmd.com/read/28852635/parental-perception-of-oral-health-related-quality-of-life-of-syrian-refugee-children
#12
Sharat Chandra Pani, Salam Atef Al-Sibai, Akanksha S Rao, Samira Najeebullah Kazimoglu, Hezekiah Adeyemi Mosadomi
AIMS AND OBJECTIVES: The conflict in Syria has resulted in the displacement of over 5 million people, many of whom intend to return home at the cessation of hostilities. Oral health plays a critical role in early childhood and this study aimed to qualitatively and quantitatively assess the oral health-related quality of life (OHRQoL) of these children. MATERIALS AND METHODS: The quantitative assessment of OHRQoL was done using a validated Arabic version of the short-form Parental-Caregiver Perceptions Questionnaire-8 (P-CPQ-8)...
July 2017: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/28846726/statistical-physics-of-balance-theory
#13
Andres M Belaza, Kevin Hoefman, Jan Ryckebusch, Aaron Bramson, Milan van den Heuvel, Koen Schoors
Triadic relationships are accepted to play a key role in the dynamics of social and political networks. Building on insights gleaned from balance theory in social network studies and from Boltzmann-Gibbs statistical physics, we propose a model to quantitatively capture the dynamics of the four types of triadic relationships in a network. Central to our model are the triads' incidence rates and the idea that those can be modeled by assigning a specific triadic energy to each type of triadic relation. We emphasize the role of the degeneracy of the different triads and how it impacts the degree of frustration in the political network...
2017: PloS One
https://www.readbyqxmd.com/read/28846018/investigating-the-effect-of-syrian-refugees-on-the-pharmaceutical-sector-in-jordan
#14
Amirah Daher, Ibrahim Alabbadi
The aim of this study was to investigate the effect of Syrian refugees on the pharmaceutical sector in Jordan. Based on a standardized methodology developed by the WHO, Level II Facility (2009) structured questionnaires (including: medicine access [availability, affordability and geographical accessibility], quality, and rational use of medicines) were used to investigate the effect of Syrian refugees influx on the pharmaceutical sector in Jordan. Lists of essential medicines (N = 50) were included in the survey forms...
August 2017: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/28836658/governing-the-lebanese-health-system-strengthening-the-national-response-to-the-burden-of-syrian-refugees
#15
Alessio Santoro, Martin McKee
Lebanon is providing sanctuary to an estimated 1.5 million Syrian refugees, with potential consequences for its health system. Here, we analyse how it has responded to this challenge, identify sensitive areas where a strong national governance system is needed and explore how it might be implemented. An effective response to the Syrian refugee crisis requires concerted international action. Nonetheless, geography dictates that the Lebanese health system must play a central role. We identify some areas where a strengthened stewardship role of the Ministry of Public Health is urgently required...
August 20, 2017: Eastern Mediterranean Health Journal, la Revue de Santé de la Méditerranée Orientale
https://www.readbyqxmd.com/read/28835274/primary-care-in-an-unstable-security-humanitarian-economic-and-political-context-the-kurdistan-region-of-iraq
#16
Ali R Shukor, Niek S Klazinga, Dionne S Kringos
BACKGROUND: This study presents a descriptive synthesis of Kurdistan Region of Iraq's (KRI) primary care system, which is undergoing comprehensive primary care reforms within the context of a cross-cutting structural economic adjustment program and protracted security, humanitarian, economic and political crises. METHODS: The descriptive analysis used a framework operationalizing Starfield's classic primary care model for health services research. A scoping review was performed using relevant sources, and expert consultations were conducted for completing and validating data...
August 23, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28831442/cancer-care-at-times-of-crisis-and-war-the-syrian-example
#17
Eman Sahloul, Riad Salem, Wessam Alrez, Tayseer Alkarim, Ammar Sukari, Wasim Maziak, M Bassel Atassi
PURPOSE: As Syria enters its fifth year of conflict, the number of civilians killed and injured continues to rise sharply. Along with this conflict comes the rapid decline of medical care, specifically cancer care. To determine physician and equipment availability, cancer screening and management, and possible solutions relative to various major cities, a survey was distributed to physicians inside Syria through the help of the humanitarian organization Syrian American Medical Society...
August 2017: Journal of Global Oncology
https://www.readbyqxmd.com/read/28828396/metabolomics-reveals-distinct-neurochemical-profiles-associated-with-stress-resilience
#18
Brooke N Dulka, Allen K Bourdon, Catherine T Clinard, Mohan B K Muvvala, Shawn R Campagna, Matthew A Cooper
Acute social defeat represents a naturalistic form of conditioned fear and is an excellent model in which to investigate the biological basis of stress resilience. While there is growing interest in identifying biomarkers of stress resilience, until recently, it has not been feasible to associate levels of large numbers of neurochemicals and metabolites to stress-related phenotypes. The objective of the present study was to use an untargeted metabolomics approach to identify known and unknown neurochemicals in select brain regions that distinguish susceptible and resistant individuals in two rodent models of acute social defeat...
December 2017: Neurobiology of Stress
https://www.readbyqxmd.com/read/28827083/combination-therapy-with-brincidofovir-and-valganciclovir-against-species-c-adenovirus-infection-in-the-immunosuppressed-syrian-hamster-model-allows-for-substantial-reduction-of-dose-for-both-compounds
#19
Karoly Toth, Ann E Tollefson, Jacqueline F Spencer, Baoling Ying, William S M Wold
Adenovirus infections of immunocompetent adults are usually mild and resolve without serious sequelae. However, adenovirus infections of immunocompromised patients often develop into life-threatening multi-organ disease. Pediatric hematopoietic transplant patients are especially threatened, with high incidence of infection and high mortality rates. Presently, there is no drug specifically approved by the FDA to treat adenovirus infections; thus there is an urgent need to develop effective antivirals against the virus...
August 4, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28826351/nurses-experiences-in-a-turkish-internal-medicine-clinic-with-syrian-refugees
#20
Sibel Sevinç
INTRODUCTION: The increasing flow of Syrian refugees to Turkey, coupled with their extended stay, highlights the need for culturally competent health care, which includes nursing interventions. PURPOSE: The purpose of this study was to describe the experiences of nurses who provide care for Syrian refugees in internal medicine clinics in a hospital located in Turkey. METHOD: This descriptive study was based on qualitative content analysis using an inductive approach and involved discovery and description of the data...
May 1, 2017: Journal of Transcultural Nursing: Official Journal of the Transcultural Nursing Society
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