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https://www.readbyqxmd.com/read/29310377/fat-grafting-for-resurfacing-an-exposed-implant-in-lower-extremity-a-case-report
#1
Yun-Nan Lin, Chieh-Han Chuang, Shih-Hao Huang, Shu-Hung Huang, Tsai-Ming Lin, I-Wen Lin, Sin-Daw Lin, Yur-Ren Kuo
RATIONALE: Although numerous reconstruction protocols have been reported for lower leg trauma, those for distal leg trauma remain few. We present the case of a woman with an implant exposure wound, who was successfully treated through fat grafting, without major flap surgery. PATIENT CONCERNS: An 83-year-old woman with an exposed implant in lower extremity received reconstruction surgery once and the surgery failed. She refused additional major surgery and negative pressure wound therapy...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29301501/inhibition-of-neddylation-facilitates-cell-migration-through-enhanced-phosphorylation-of-caveolin-1-in-pc3-and-u373mg-cells
#2
Sung Yeon Park, Jong-Wan Park, Gun-Woo Lee, Lan Li, Yang-Sook Chun
BACKGROUND: Protein neddylation is a post-translational modification by a covalent conjugation with the neural precursor cell expressed, developmentally downregulated 8 (NEDD8). Although this process has been reported to participate in diverse cellular signaling, little is known about its role in cancer cell migration. Given a recent proteomics report showing that NEDD8 is downregulated in prostate cancer tissues versus normal prostate tissues, we tested the possibility that neddylation plays a role in cancer evolution, and then tried to identify target proteins of the neddylation...
January 5, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29285837/the-new-metformin-derivative-hl156a-prevents-oral-cancer-progression-by-inhibiting-the-igf-akt-mtor-pathways
#3
Thuy Giang Lam, Yun Soo Jeong, Soo-A Kim, Sang-Gun Ahn
Metformin is a biguanide widely prescribed as an antidiabetic drug for type 2 diabetes mellitus patients. The purpose of this study was to observe the effects of the new metformin derivative, HL156A, on human oral cancer cell and to investigate its possible mechanisms. It was observed that HL156A significantly decreased FaDu and YD-10B cell viability and colony formation in a dose dependent manner. HL156A also markedly reduced wound closure and migration of FaDu and YD-10B cells. We observed that HL156A decreased mitochondrial membrane potential and induced ROS levels and apoptotic cells with caspase-3 and -9 activation...
December 29, 2017: Cancer Science
https://www.readbyqxmd.com/read/29204726/psychopathology-and-associated-risk-factors-among-forcibly-displaced-syrian-children-and-adolescents
#4
Vahdet Gormez, Hale Nur Kılıç, A Cahid Orengul, Merve Nursoy Demir, Şeyma Demirlikan, Sibel Demirbaş, Betül Babacan, Kerem Kınık, Bengi Semerci
More than half of the 2.7 million registered Syrian refugees in Turkey are under 18 years of age. This study investigates prevalence of psychopathology and associated risk factors in refugee children in Turkey. Of a total of 218 children aged 9-15 years, 56.2% lost someone important to them, 55.1% saw dead or wounded people, 70.4% witnessed explosions or gun battles, 42.5% witnessed people being tortured and 25.6% personally experienced cruelty/torture during war. Prevalence of PTSD was 18.3% and that of anxiety-related disorders were as high as 69...
December 4, 2017: Journal of Immigrant and Minority Health
https://www.readbyqxmd.com/read/29202658/ambroise-par%C3%A3-1510-1590-and-his-innovative-work-on-the-treatment-of-war-injuries
#5
Konstantinos Markatos, Anna Tzivra, Spyridon Tsoutsos, Gerasimos Tsourouflis, Marianna Karamanou, Georgios Androutsos
The purpose of this study is to summarize the innovations of Ambroise Paré (1510-1590) on the treatment of war wounds and improving amputation technique through ligature in arteries and veins. Ambroise Paré debunked the widely accepted idea that gun powder was poisonous for wounds. He also minimized the use of cautery of wounds by his dressing methods and the application of ligature during amputations. All these innovative rationales revolutionized the practice of war surgery during the Renaissance and paved the way for the introduction of modern surgery...
December 1, 2017: Surgical Innovation
https://www.readbyqxmd.com/read/29202338/cranial-trauma-in-handgun-executions-experimental-data-using-polyurethane-proxies
#6
Seth C Taylor, Elena F Kranioti
Gun violence is a global phenomenon with regional variation in frequency and severity. Handguns are often used in violent deaths such as suicides and homicides. Hence, ballistic trauma is a critical subject of forensic investigations. Trauma patterns are fundamental evidence for the reconstruction of the incident and for the determination of the manner of death. This study investigated the differences in trauma patterns with a series of experiments using six different calibers (.22 LR, .38 Special, .380 ACP, 9×19mm, ...
November 27, 2017: Forensic Science International
https://www.readbyqxmd.com/read/29191407/occupational-outcomes-following-combat-related-gunshot-injury-cohort-study
#7
Matthew D Laughlin, Philip J Belmont, Paul J Lanier, Julia O Bader, Brian R Waterman, Andrew J Schoenfeld
BACKGROUND: The long-term impact of gun violence on physical function and occupational disability remains poorly explored. We sought to examine the effect of combat-related gunshot injury on work capacity within a cohort of military servicemembers and identify clinical characteristics that influence the capacity to return to work. METHODS: A query was performed to identify all servicemembers injured by gunshot in the years 2005-2009. These soldiers were then followed for a period up to the end of 2014 in order to identify those separated from service due to an inability to perform military duties as a result of their injury...
November 27, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/29078894/the-utility-of-presacral-drainage-in-penetrating-rectal-injuries-in-adult-and-pediatric-patients
#8
Kate B Savoie, Thomas M Beazley, Brent Cleveland, Sina Khaneki, Troy A Markel, Peter M Hammer, Stephanie Savage, Regan F Williams
BACKGROUND: With changing weaponry associated with injuries in civilian trauma, there is no clinical census on the utility of presacral drainage (PSD) in penetrating rectal injuries (PRIs), particularly in pediatric patients. METHODS: Patients with PRI from July 2004-June 2014 treated at two free-standing children's hospitals and two adult level 1 trauma centers were compared by age (pediatric patients ≤16 years) and PSD. A stratified analysis was performed based on age...
November 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/29058106/line-of-fire-what-happened-at-the-wantabadgery-seige
#9
Roger W Byard, Adam Ford, Tony Raymond, Jeremy J Sofonia, Owen Kaluza, David G Barnes
A gunfight between police and a gang of men led by the self-styled "Captain Moonlite", a.k.a. George Scott, occurred on 16th November 1879 at a farmhouse near Wantabadgery Station in the colony of New South Wales. The skirmish resulted in the deaths of two bushrangers and one police officer. As a result, Captain Moonlite and Thomas Rogan were hung in Sydney's Darlinghurst Gaol on 20 January 1880 for the murder of Constable Edward Webb-Bowen. Culpability for firing the fatal shot, however, has remained a source of controversy...
October 23, 2017: Forensic Science, Medicine, and Pathology
https://www.readbyqxmd.com/read/29017638/the-difference-between-living-and-dying-victim-characteristics-and-motive-among-nonfatal-shootings-and-gun-homicides
#10
Natalie Kroovand Hipple, Lauren A Magee
Using both official and unofficial data sources, researchers examined nonfatal (n = 617) and fatal shooting (n = 159) victim characteristics over an 18-month period in Indianapolis. This research revealed that the typical shooting victim was male, non-White, almost 29 years old, had been arrested prior to inclusion in this study, and had been shot more than once. Interestingly, this research supports the notion that nonfatal shooting and homicide victims are different, especially as they relate to victim age, gunshot wound severity, and shooting motive...
October 10, 2017: Violence and Victims
https://www.readbyqxmd.com/read/28940356/controversial-suicide-case-using-a-submachine-gun-with-a-sound-suppressor-the-need-of-team-work-of-forensic-chemistry-and-firearm-examiners
#11
Zuzanna Brożek-Mucha, Krzysztof Zdeb
Evidence materials in a presumed suicide case were studied by a firearm examiner and a forensic chemist. The victim's body with double gunshot wounding in his forehead, a machine gun in the sustained fire mode with a silencer, and four cartridge cases were found. Examinations of the evidence, the case file studies, and experiments dedicated to the case were carried out. Relationships between the placement of cartridge cases and the gun were established using a fast camera. The distributions of gunshot residues on the evidence materials and within the comparative gunshot patterns were studied by means of optical and electron microscopy, X-ray microanalysis, and infrared spectroscopy...
September 20, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28898794/surgical-management-of-late-bullet-embolization-from-the-abdomen-to-the-right-ventricle-case-report
#12
Ramos Mayo Alan Elison, Diaz Elizondo Jose Antonio, Segura Marin Hector, Lopez Garnica Dolores, Treviño Garza Francisco Xavier
INTRODUCTION: Secondary embolus from gun projectile is a rare entity, it represents a clinical and therapeutic dilemma because the potential complications involving central and peripheral circulation. Each case reported in the literature represents a challenge because their unique and different clinical scenarios. PRESENTATION OF CASE: We present the management of a 33-year-old man with past history of a gunshot wound on left flank with no evidence of any exit wounds, treated with exploratory laparotomy without removing the gunshot bullet from the abdomen...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28888336/pediatric-firearm-deaths-and-injuries-in-the-united-states
#13
Deborah L McBride
Guns are the third leading cause of death of those aged 1 to 17years, outpaced only by unintentional injuries such as car crashes and drowning, and illnesses like cancer according to a new federal study. The new study, which has been called the most comprehensive examination of current firearms-related deaths and injury among children in the United States used data from the National Electronic Injury Surveillance System and the Centers for Disease Control and Prevention (CDC) National Violent Death Reporting System to assess the magnitude and characteristics of firearm-related deaths and injuries among children (age 0-17years) from 2002 to 2014...
September 6, 2017: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/28876574/holding-the-torch-up-high-a-medical-historical-evaluation-of-surgical-advances-during-the-great-war-1914-1918-in-memory-of-those-that-served-and-fell
#14
G Scharf
"How wide and varied is the experience of the battlefield and how fertile the blood of warriors in raising good surgeons" Sir Clifford Allbutt (1898). With these sentiments of the medical lessons learned in war and conflict, with the background of the poem of "In Flanders Field", written by a doctor who had South African War connections, reasons (the Somme and third Ypres battles) will be given that this was indeed a "GREAT WAR" as the world history, weapons, strategy, tactics and wounding patterns had changed dramatically...
September 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28873453/satellite-tagging-of-rehabilitated-green-sea-turtles-chelonia-mydas-from-the-united-arab-emirates-including-the-longest-tracked-journey-for-the-species
#15
David P Robinson, Rima W Jabado, Christoph A Rohner, Simon J Pierce, Kevin P Hyland, Warren R Baverstock
We collected movement data for eight rehabilitated and satellite-tagged green sea turtles Chelonia mydas released off the United Arab Emirates between 2005 and 2013. Rehabilitation periods ranged from 96 to 1353 days (mean = 437 ± 399 days). Seven of the eight tagged turtles survived after release; one turtle was killed by what is thought to be a post-release spear gun wound. The majority of turtles (63%) used shallow-water core habitats and established home ranges between Dubai and Abu Dhabi, the same area in which they had originally washed ashore prior to rescue...
2017: PloS One
https://www.readbyqxmd.com/read/28853319/fabrication-and-characterization-of-phlorotannins-poly-vinyl-alcohol-hydrogel-for-wound-healing-application
#16
Hyeon-Ho Park, Seok-Chun Ko, Gun-Woo Oh, Soo-Jin Heo, Do-Hyung Kang, Sung-Yong Bae, Won-Kyo Jung
Phlorotannins (PH) derived from brown algae have been shown to have biological effects. However, the application of PH in biomedical materials has not been investigated. Here, we investigated the effects of PH on normal human dermal fibroblast (NHDF) proliferation and fabricated a composite hydrogel consisting PH and poly (vinyl alcohol) (PVA) (PVA/PH) by a freezing-thawing method for wound healing applications. Cell proliferation was significantly higher in the PH-treated (0.01 and 0.02%) cells than in non-treated cells...
August 30, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28747631/jmjd3-and-nf-%C3%AE%C2%BAb-dependent-activation-of-notch1-gene-is-required-for-keratinocyte-migration-during-skin-wound-healing
#17
Jungtae Na, Jee Yoon Shin, Hayan Jeong, Jee Youn Lee, Beom Joon Kim, Won Sun Kim, Tae Young Yune, Bong-Gun Ju
It has been shown that epigenetic regulation plays an important role in skin wound healing. We previously found that histone H3K27me3 demethylase JMJD3 regulates inflammation and cell migration in keratinocyte wound healing. In this study, we identified Notch1 as a direct target of JMJD3 and NF-κB in wounded keratinocytes using in vitro cell and in vivo animal models. We found that Notch1 is up-regulated in the wound edge and its expression is dependent on JMJD3 and NF-κB in wounded keratinocytes. We also found that Notch1 activates the expression of RhoU and PLAU gene, which are critical regulators of cell migration...
July 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28717964/wound-morphology-in-contact-shots-from-blank-cartridge-handguns-a-study-on-composite-models
#18
Rebecca Pircher, Markus Große Perdekamp, Annette Thierauf-Emberger, Lena Kramer, Stefan Pollak, Dorothee Geisenberger
It is a well-known fact that blank cartridge guns can cause penetrating and even fatal injuries when discharged in contact or at very close ranges. In these cases, the gas jet perforates the skin leaving an entrance wound similar to that from a conventional gun. In order to investigate the wound morphology in contact shots from blank firearms, test shots were fired at composite models of pig skin and gelatin blocks using three different calibre 9-mm blank cartridge handguns (two pistols and one revolver) and two types of ammunition...
July 17, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28697020/good-news-bad-news-an-analysis-of-11-294-gunshot-wounds-gsws-over-two-decades-in-a-single-center
#19
Nathan R Manley, Timothy C Fabian, John P Sharpe, Louis J Magnotti, Martin A Croce
INTRODUCTION: Gun violence is a substantial public health problem accounting for significant physical, psychological and financial costs. While aggregate data sources demonstrate decreasing rates of firearm violence, analyses from individual trauma centers have shown that mortality and injury severity from GSWs are increasing. To evaluate the evolving characteristics of gun violence in our region, we studied all GSWs admitted to our trauma center over a twenty-year period. METHODS: A retrospective analysis of all newly admitted patients with GSWs was performed from 1996 to 2016...
July 8, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28684299/cyperus-amuricus-induces-g1-arrest-and-apoptosis-through-endoplasmic-reticulum-stress-and-mitochondrial-signaling-in-human-hepatocellular-carcinoma-hep3b-cells
#20
Hai Ha Thi Pham, Yeong-Ae Seong, Daniel Ngabire, Chul-Woong Oh, Gun-Do Kim
ETHNOPHARMACOLOGY RELEVANCE: Cyperus amuricus (C. amuricus), belongs to the family Cyperaceae, was used to exert wound healing, diuretic, astringent and other intestinal problems in oriental medicine. However, only a few studies have reported its anticancer activities. AIM OF THE STUDY: In this study, we determined the activity of C. amuricus on ER stress-induced cell death and G1 cell cycle arrest in human hepatocellular carcinoma (HCC) Hep3B cells. MATERIALS AND METHODS: The in vitro cell proliferation assay of C...
July 4, 2017: Journal of Ethnopharmacology
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