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https://www.readbyqxmd.com/read/27805995/rapid-thrombelastography-r-teg-thresholds-for-goal-directed-resuscitation-of-patients-at-risk-for-massive-transfusion
#1
Peter M Einersen, Ernest E Moore, Michael P Chapman, Hunter B Moore, Eduardo Gonzalez, Christopher C Silliman, Anirban Banerjee, Angela Sauaia
BACKGROUND: Uncontrolled hemorrhage is a leading cause of mortality following trauma accounting for up to 40% of deaths. Massive transfusion protocols (MTPs) offer a proven benefit in resuscitation of these patients. Recently, the superiority of thrombelastography (TEG)-guided resuscitation over strategies guided by conventional clotting assays (CCA) has been established. We seek to determine optimal thresholds for r-TEG driven resuscitation. METHODS: R-TEG data were reviewed for 190 patients presenting to our Level 1 Trauma Center from 2010 to 2015...
October 31, 2016: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/27776550/euphorbia-humifusa-willd-exerts-inhibition-of-breast-cancer-cell-invasion-and-metastasis-through-inhibition-of-tnf%C3%AE-induced-mmp-9-expression
#2
Soon Young Shin, Chang Gun Kim, You Jung Jung, Yearam Jung, Hyeryoung Jung, Jihyun Im, Yoongho Lim, Young Han Lee
BACKGROUND: Breast cancer is the most common type of malignancy in women worldwide. Euphorbia humifusa Willd (EuH) is a plant that is widely used as a traditional medicine. However, no systemic studies on the anti-cancer effects of EuH have been reported. The aim of this study is to evaluate the anti-metastatic effect of the EuH. METHODS: Ethyl acetate fraction was prepared from EuH methanol extracts (EA/EuH). Inhibitory effect of EA/EuH on cell migration was determined using an in vitro scratch-wound healing assay...
October 24, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27761714/advantages-of-laparoscopic-compared-to-conventional-surgery-are-not-related-to-an-innate-immune-response-of-peritoneal-immune-activation-an-animal-study-in-rats
#3
Philipp Lingohr, Jonas Dohmen, Hanno Matthaei, Timo Schwandt, Kathy Stein, Gun-Soo Hong, Julia Steitz, Thomas Longerich, Edwin Bölke, Sven Wehner, Jörg C Kalff
PURPOSE: Laparoscopic surgery (LS) has proved superior compared to conventional surgery (CS) regarding morbidity, length of hospital stay, rate of wound infection and time until recovery. An improved preservation of the postoperative immune function is assumed to contribute to these benefits though the role of the local peritoneal immune response is still poorly understood. Our study investigates the peritoneal immune response subsequent to abdominal surgery and compares it between laparoscopic and conventional surgery to find an immunological explanation for the clinically proven benefits of LS...
October 19, 2016: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/27744527/bullet-fragmentation-preceding-a-contour-shot-case-study-and-experimental-simulation
#4
V Sterzik, B P Kneubuehl, M Bohnert, F Riva, M Glardon
In medico-legal literature, only a small number of publications deal with lethal injuries caused by shots with modified guns. This might lead to the conclusion that such cases are extremely rare. However, there are cases again and yet again. During the investigation process, the modified gun is of particular importance since it can show an unusual ballistic behaviour. The present paper reports on a suicide of a 60-year-old man, committed with a modified revolver and a lead bullet. The man had a single gunshot wound with entrance at the right temporal bone...
October 15, 2016: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/27739911/emergence-of-form-from-function-mechanical-engineering-approaches-to-probe-the-role-of-stem-cell-mechanoadaptation-in-sealing-cell-fate
#5
Melissa L Knothe Tate, Peter W Gunning, Vittorio Sansalone
Stem cell "mechanomics" refers to the effect of mechanical cues on stem cell and matrix biology, where cell shape and fate are intrinsic manifestations of form and function. Before specialization, the stem cell itself serves as a sensor and actuator; its structure emerges from its local mechanical milieu as the cell adapts over time. Coupling of novel spatiotemporal imaging and computational methods allows for linking of the energy of adaptation to the structure, biology and mechanical function of the cell...
October 14, 2016: Bioarchitecture
https://www.readbyqxmd.com/read/27721003/quadriparesis-caused-by-lead-poisoning-nine-years-after-a-gunshot-wound-with-retained-bullet-fragments-a-case-report
#6
Emma Nally, James Jelinek, Robert D Bunning
: Lead toxicity in adults is characterized by nonspecific symptoms of abdominal pain, vomiting, constipation, fatigue, and weight loss. We present a case of severe lead toxicity that developed subacutely, causing quadriparesis 9 years after a gunshot wound with retained bullet fragments. The onset of symptoms may have been related to the development of a pseudocyst. The long interval between the gunshot wound and the onset of symptoms contributed to a delay in suspecting that the retained bullet was a source of lead toxicity...
October 6, 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/27718011/gun-barrel-view-of-the-anterior-pelvic-ring-for-percutaneous-anterior-column-or-superior-pubic-ramus-screw-placement
#7
Nicholas Quercetti, Brandon Horne, Zac DiPaolo, Michael J Prayson
BACKGROUND: Traditionally, operative fixation of pelvic and acetabular injuries involves complex approaches and significant complications. Accelerated rehabilitation, decreased soft tissue stripping and decreased wound complications are several benefits driving a recent interest in percutaneous fixation. We describe a new fluoroscopic view to guide the placement of screws within the anterior pelvic ring. METHODS: Twenty retrograde anterior pelvic ring screws were percutaneously placed in ten cadaveric specimens...
October 7, 2016: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/27681360/targeting-of-sebaceous-glands-to-treat-acne-by-micro-insulated-needles-with-radio-frequency-in-a-rabbit-ear-model
#8
Tae-Rin Kwon, Eun Ja Choi, Chang Taek Oh, Dong-Ho Bak, Song-I Im, Eun Jung Ko, Hyuck Ki Hong, Yeon Shik Choi, Joon Seok, Sun Young Choi, Gun Young Ahn, Beom Joon Kim
BACKGROUND AND OBJECTIVES: Many studies have investigated the application of micro-insulated needles with radio frequency (RF) to treat acne in humans; however, the use of a micro-insulated needle RF applicator has not yet been studied in an animal model. The purpose of this study was to evaluate the effectiveness of a micro-insulated needle RF applicator in a rabbit ear acne (REA) model. STUDY DESIGN/MATERIALS AND METHODS: In this study, we investigated the effect of selectively destroying the sebaceous glands using a micro-insulated needle RF applicator on the formation of comedones induced by application of 50% oleic acid and intradermal injection of P...
September 29, 2016: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/27673104/poster-350-persistent-pneumocephalus-after-gun-shot-wound-to-the-head
#9
Kunj G Patel, Lauren E Brandes, Srikanth Kurapati, Emily Boyd, Andrew C Dennison
No abstract text is available yet for this article.
September 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/27667556/the-herbal-medicine-cyperus-amuricus-inhibits-proliferation-of-human-hepatocellular-carcinoma-hep3b-cells-by-inducing-apoptosis-and-arrest-at-the-g0-g1-cell-cycle-phase
#10
Hai Ha Thi Pham, Yeong-Ae Seong, Chul-Woong Oh, Gun-Do Kim
Cyperus amuricus (C. amuricus) is one of the most common herbs in Oriental folk medicine for exerting astringent, diuretic, wound healing and other intestinal problems. However, little is known about the molecular mechanism of C. amuricus on anticancer activity. In the present study, the underlying mechanism of the anticancer effect of C. amuricus were elucidated. The methyl alcohol extract from the whole plant of C. amuricus exhibited cytotoxicity against Hep3B cells, but not against A549 and HaCaT cells...
September 20, 2016: International Journal of Oncology
https://www.readbyqxmd.com/read/27651868/which-one-is-better-to-reduce-the-infection-rate-early-or-late-cranioplasty
#11
Jae-Sang Oh, Kyeong-Seok Lee, Jai-Joon Shim, Seok-Mann Yoon, Jae-Won Doh, Hack-Gun Bae
OBJECTIVE: Decompressive craniectomy is an effective therapy to relieve high intracranial pressure after acute brain damage. However, the optimal timing for cranioplasty after decompression is still controversial. Many authors reported that early cranioplasty may contribute to improve the cerebral blood flow and brain metabolism. However, despite all the advantages, there always remains a concern that early cranioplasty may increase the chance of infection. The purpose of this retrospective study is to investigate whether the early cranioplasty increase the infection rate...
September 2016: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/27622112/pediatric-arm-reconstruction-after-shot-gun-injury-using-peroneal-free-flap-and-pedicled-latissimus-dorsi-muscle-flap-late-follow-up
#12
Carlos Olvera-Caballero, Abel Ortiz-Dominguez
A 15-year-old patient harmed himself upon firing a shotgun that he was carrying when he slipped and fell, causing a destructive wound in the right arm with a medial entry hole and a posterolateral exit hole. The biceps, coracobrachialis, triceps, deltoids, skin cover, and humerus were injured; however, the blood vessels and major nerves of the area were surprisingly not affected. The residual skin muscle defect after debridements was 16 × 5 cm medially and posteriorly, and the bone loss was 7 cm. The wound was reconstructed during a single surgery with a free fibula flap and a pedicled flap of latissimus dorsi...
August 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/27604997/potential-role-of-marine-algae-extract-on-3t3-l1-cell-proliferation-and-differentiation-an-in-vitro-approach
#13
Soundharrajan Ilavenil, Da Hye Kim, Mayakrishnan Vijayakumar, Srisesharam Srigopalram, Sang Gun Roh, Mariadhas Valan Arasu, Jong Suk Lee, Ki Choon Choi
BACKGROUND: From ancient times, marine algae have emerged as alternative medicine and foods, contains the rich source of natural products like proteins, vitamins, and secondary metabolites, especially Chlorella vulgaris (C. vulgaris) contains numerous anti-inflammatory, antioxidants and wound healing substances. Type 2 diabetes mellitus is closely associated with adipogenesis and their factors. Hence, we aimed to investigate the chemical constituents and adipogenic modulatory properties of C...
September 7, 2016: Biological Research
https://www.readbyqxmd.com/read/27593715/acquired-spinal-arteriovenous-fistula-presenting-as-brown-s%C3%A3-quard-syndrome-and-endovascular-treatment-outcome
#14
Rizvi Humaira, Chiu Yuen To, Shyam Moudgil, Richard Fessler
BACKGROUND: Brown-Séquard syndrome is typically caused by penetrating trauma to the cervical spinal cord; however, other compressive and vascular occlusive etiologies have been previously described. It is extremely uncommon to have a delayed presentation as an extramedullary compressive lesion from the venous varix of an acquired spinal arteriovenous fistula. CASE DESCRIPTION: We present a case of a patient in the fifth decade of life, with a remote history of gunshot wound to the left thorax with progressive left-sided weakness and contralateral pain and temperature sensory loss secondary to cord compression from an acquired spinal arteriovenous fistula...
September 2, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27591065/airgun-shot-wound-to-the-orbit-with-retention-of-pellet-case-report-and-review-of-the-literature
#15
Paweł Daszkiewicz, Dariusz Dziedzic, Piotr Daszkiewicz
Shot wounds become a growing clinical concern in the civilian setting, due to increasing popularity of air guns among minors. We present a pediatric case of a shot wound to the orbit with sparing of the eyeball and retention of airgun pellet in the retrobulbar space. The pellet was removed 3 months after injury via lateral orbitotomy. Pathophysiology and ballistics of shot wounds are briefly reviewed and current views on the management strategy of shot wounds with retained projectile are discussed.
2016: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/27546337/surgical-resection-for-epilepsy-following-cerebral-gun-shot-wounds
#16
Yoshua Esquenazi, Giridhar P Kalamangalam, Omotola A Hope, Sonia N Krish, Jeremy Slater, Nitin Tandon
OBJECTIVE: The surgical management of epilepsy following penetrating gunshot wounds (GSWs) to the head has not been described in the modern; era. Given the extensive damage to the cranium and cortex from such; injuries, the safety and efficacy of surgical intervention is unclear. We; report the surgical strategy and outcomes following resections for; medically refractory epilepsy following GSWs in four patients. METHODS: A prospectively compiled database of 325 epilepsy patients was used to identify patients undergoing epilepsy surgery for medically; refractory epilepsy following a GSW to the brain...
August 18, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27537508/a-prospective-randomized-study-of-the-efficacy-of-turning-point-an-inpatient-violence-intervention-program
#17
Catherine Loveland-Jones, Lucas Ferrer, Scott Charles, Frederick Ramsey, Andrea van Zandt, Jill Volgraf, Thomas Santora, Abhijit Pathak, Jay Dujon, Lars Sjoholm, Joseph Rappold, Amy Goldberg
BACKGROUND: From 2002 to 2011, there were more than 17,000 shootings in Philadelphia. "Turning Point," Temple University Hospital's inpatient violence intervention program, takes advantage of the teachable moment that occurs after violent injury. In addition to receiving traditional social work services, Turning Point patients watch their trauma bay resuscitation video and a movie about violence, meet with a gunshot wound survivor and an outpatient case manager, and also undergo psychiatric assessment...
November 2016: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/27434956/-characteristics-of-antibioticoresistance-of-microflora-in-a-combat-the-gun-shot-ano-the-mine-explosion-wounds-of-the-extremities
#18
V M Kondratyuk
Abstract Results of bacteriological investigations of a gun-shot and a mine-explosion woundings of the extremities were analyzed in Military-Medical Clinical Centres (MMCC) of Kyiv, Lviv and Vinnytsya. Spectrum of the allotted microorganisms and profile of their antibioticoresistance were disclosed. The patterns of resistance were determined in accordance to offering of international experts of European Committee on Antimicrobial Susceptibility Testing (EUCAST). Dominating microflora in a Chief MMCC (Kyiv) and MMCC of a Western Region (Lviv) were various species of the Enterobacteriaceae and P...
April 2016: Klinichna Khirurhiia
https://www.readbyqxmd.com/read/27355740/watertight-sealing-without-lumbar-drainage-for-incidental-ventral-dural-defect-in-transthoracic-spine-surgery-a-retrospective-review-of-53-cases
#19
Sang-Hyeop Jeon, Sang-Ho Lee, Yi Sheng Tsang, Tag-Geun Jung, Ki-Hyoung Moon, Gun Choi, Ketan Deshpande
STUDY DESIGN: A retrospective review. OBJECTIVES: To evaluate the therapeutic efficacy of the triple layer closure technique to establish watertight sealing without diversion of lumbar drainage, in preventing persistent incidental subarachnoid-pleural fistula and other neurologic complications related to excessive drainage of cerebrospinal fluid (CSF) after dural defect in transthoracic ossified posterior longitudinal ligament (OPLL) surgery. SUMMARY OF BACKGROUND DATA: Cerebrospinal fluid (CSF) leakage into the pleural cavity leads to unfavorable conditions for natural healing of incidental durotomy due to the negative pressure environment of the pleural space and lack of wound healing around the bony cavity near the decompressed spinal cord...
June 28, 2016: Clinical Spine Surgery
https://www.readbyqxmd.com/read/27341782/fabrication-characterization-and-determination-of-biological-activities-of-poly-%C3%AE%C2%B5-caprolactone-chitosan-caffeic-acid-composite-fibrous-mat-for-wound-dressing-application
#20
Gun-Woo Oh, Seok-Chun Ko, Jae-Young Je, Young-Mog Kim, JungHwan Oh, Won-Kyo Jung
In the present study, we designed composite fibrous mats consisting of poly (ε-caprolactone) (PCL), chitosan (CH), or chitosan-caffeic acid conjugate (CCA) fabricated by an electrospinning technique for wound dressing application. The average diameters of PCL, PCL/CH, and PCL/CCA composite fibrous mats were 1.30±1.07, 1.20±1.22, and 0.94±0.68μm, respectively. Based on universal tensile machine (UTM) analysis, the PCL/CCA composite significantly increased tensile properties compared with the PCL and PCL/CH composites...
June 21, 2016: International Journal of Biological Macromolecules
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