keyword
MENU ▼
Read by QxMD icon Read
search

SEH

keyword
https://www.readbyqxmd.com/read/28737329/-mobile-emergency-care-medical-records-audit-the-need-for-tunisian-guidelines
#1
Manel Mallouli, Imen Hchaichi, Asma Ammar, Jihène Sehli, Chekib Zedini, Ali Mtiraoui, Thouraya Ajmi
: This audit identified minor dysfunctions that could be due to the absence of local guidelines concerning medical records in general and more specifically SMUR. Corrective measures were set up in the context of a short-term and intermediate-term action plan.<np pagenum="072"/> </ce:para>.
March 6, 2017: Santé Publique: Revue Multidisciplinaire Pour la Recherche et L'action
https://www.readbyqxmd.com/read/28736260/soluble-epoxide-hydrolase-activation-by-s-nitrosation-contributes-to-cardiac-ischemia-reperfusion-injury
#2
Yuzhu Ding, Yazi Li, Xu Zhang, Jinlong He, Dong Lu, Xuan Fang, Yuchen Wang, Jiaxing Wang, Yuying Zhang, Xinhua Qiao, Li-Ming Gan, Chang Chen, Yi Zhu
Cardiac ischemia-reperfusion (I/R) injury always accompanies recanalization treatment for myocardial infarction. Here we found soluble epoxide hydrolase (sEH), which metabolizes cardioprotective epoxyeicosatrienoic acids into less effective diols, was rapidly activated during myocardial reperfusion in both mouse and rat models in expression-independent manner. Similar activation was mimicked by nitric oxide (NO) donor dose-dependently in vitro, along with an obvious induction of sEH S-nitrosation, a short-term post-translational modification, which diminished in sEH Cys-141-Ala mutant...
July 20, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/28735055/molecular-analysis-of-virulence-genes-and-the-accessory-gene-regulator-agr-types-among-methicillin-resistant-staphylococcus-aureus-mrsa-strains
#3
Sara Cheraghi, Leyla Pourgholi, Maryam Shafaati, Shirinsadat Hashemi Fesharaki, Arash Jalali, Rahim Nosrati, MohammadAli Boroumand
OBJECTIVES: Methicillin resistant S. aureus (MRSA) strains are a main cause of hospital-acquired infections and are considered as a serious public-health concern. MRSA isolates have plenty of virulence factors, which are the basis for its pathogenicity. The controlling and coordination of the expression of these genes perform by the accessory gene regulator (agr). The aim of this study was to determine the rate of some virulence genes encoding the enterotoxin, exfoliative toxin genes (eta), the adhesin genes and identification of agr specificity groups in MRSA isolates...
July 19, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28729209/clonal-spread-of-methicillin-resistant-staphylococcus-aureus-t6065-cc5-sccmecv-agrii-in-a-libyan-hospital
#4
Monia Khemiri, Ali Akrout Alhusain, Mohamed Salah Abbassi, Houyem El Ghaieb, Sofia Santos Costa, Adriana Belas, Constança Pomba, Salah Hammami
OBJECTIVES: The aim of this study was to characterize 32 MRSA isolates recovered from wound specimens of patients in a Hospital in Tripoli, Libya, during 2013. METHODS: MRSA isolates were characterized by determining their antibiotic susceptibilities, genes encoding antibiotic resistance and virulence factors, the SCCmec class, agr type, spa typing, PFGE and MLST. RESULTS: PFGE and MLST revealed that all isolates were clonal and belonged to the Clonal Complex 5 (CC5)...
July 17, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28729091/phosphatase-activity-of-soluble-epoxide-hydrolase
#5
REVIEW
Jan Kramer, Ewgenij Proschak
Soluble epoxide hydrolase (sEH) is a bifunctional enzyme that exhibits lipid epoxide hydrolase (sEH-H) and lipid phosphatase activity (sEH-P), with each being located in its own distinct domain. While the epoxide hydrolase activity is well-investigated, the role of the phosphatase domain remains unclear. This article briefly summarizes the evolution, structure and SNPs of the human sEH, with a special focus on the function and postulated role of the N-terminal domain of sEH. Furthermore, the article provides an overview of tools to study sEH-P...
July 17, 2017: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/28707660/-increase-in-the-concentration-of-seh-protein-in-renal-medulla-of-isiah-rats-with-inherited-stress-induced-arterial-hypertension
#6
T O Abramova, M A Ryazanova, E V Antonov, O E Redina, A L Markel
The concentration of soluble epoxide hydrolase (sEH) protein was studied in renal medulla of adult rats from hypertensive ISIAH strain and normotensive WAG strain. The sEH is a key enzyme in metabolism of epoxyeicosatrienoic acids capable of activating endothelial NO-synthase and nitrogen oxide formation, and therefore being vasodilators. An increase in the sEH protein concentration (that we found) allows one to assume that the oxidative stress is increased in the renal medulla of hypertensive rats, and the bloodflow is decreased...
May 2017: Molekuliarnaia Biologiia
https://www.readbyqxmd.com/read/28699310/the-effects-of-seh-inhibitor-on-depression-like-behavior-and-neurogenesis-in-male-mice
#7
Qiong Wu, Hongyang Cai, Jingfang Song, Quanzhong Chang
Currently antidepressants take several weeks to be effective, which is one of the main reasons why patients with depression quit therapy. In the present study, we examine the acute and subacute effects of soluble epoxide hydolase (sEH) inhibitor (sEHI), a compound shown to have antidepressant effects, on mice. We found that acute administration of sEHI TPPU decreases immobility time in the forced swimming test and reduces latency to feed in the novelty suppressed-feeding test in adult male mice. Intraperitoneal administration of TPPU for seven days also increased interaction time of socially defeated mice in the social defeat test...
July 12, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/28694203/soluble-epoxide-hydrolase-inhibitor-auda-decreases-bleomycin-induced-pulmonary-toxicity-in-mice-by-inhibiting-the-p38-smad3-pathways
#8
Xin-Wei Dong, Yong-Liang Jia, Ling-Tian Ge, Bo Jiang, Jun-Xia Jiang, Jian Shen, Ya-Chao Jin, Yan Guan, Yun Sun, Qiang-Min Xie
Bleomycin (BLM) has potent tumor cell-killing properties that have given it an important place in cancer chemotherapy, but pulmonary toxicity is its major adverse effect. Soluble epoxide hydrolase (sEH) inhibitors have been reported to have protective effects in fibrosis models, but the effects of AUDA, an sEH inhibitor of BLM-induced pulmonary toxicity and fibrosis, remain to be researched. In this study, we assessed the effects of AUDA on the BLM-induced pulmonary fibrosis in a mouse model, and transforming growth factor (TGF)-β1-induced epithelial proliferation and epithelial-mesenchymal transition (EMT) in vitro by monitoring changes in pulmonary function, inflammatory response, fibrotic remodeling, and signaling pathways...
July 8, 2017: Toxicology
https://www.readbyqxmd.com/read/28680138/investigation-of-thermally-induced-degradation-in-ch3nh3pbi3-perovskite-solar-cells-using-in-situ-synchrotron-radiation-analysis
#9
Nam-Koo Kim, Young Hwan Min, Seokhwan Noh, Eunkyung Cho, Gitaeg Jeong, Minho Joo, Seh-Won Ahn, Jeong Soo Lee, Seongtak Kim, Kyuwook Ihm, Hyungju Ahn, Yoonmook Kang, Hae-Seok Lee, Donghwan Kim
In this study, we employ a combination of various in-situ surface analysis techniques to investigate the thermally induced degradation processes in MAPbI3 perovskite solar cells (PeSCs) as a function of temperature under air-free conditions (no moisture and oxygen). Through a comprehensive approach that combines in-situ grazing-incidence wide-angle X-ray diffraction (GIWAXD) and high-resolution X-ray photoelectron spectroscopy (HR-XPS) measurements, we confirm that the surface structure of MAPbI3 perovskite film changes to an intermediate phase and decomposes to CH3I, NH3, and PbI2 after both a short (20 min) exposure to heat stress at 100 °C and a long exposure (>1 hour) at 80 °C...
July 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28672788/n-3-polyunsaturated-fatty-acids-decrease-the-protein-expression-of-soluble-epoxide-hydrolase-via-oxidative-stress-induced-p38-kinase-in-rat-endothelial-cells
#10
Takashi Okada, Katsutaro Morino, Fumiyuki Nakagawa, Masashi Tawa, Keiko Kondo, Osamu Sekine, Takeshi Imamura, Tomio Okamura, Satoshi Ugi, Hiroshi Maegawa
N-3 polyunsaturated fatty acids (PUFAs) improve endothelial function. The arachidonic acid-derived metabolites (epoxyeicosatrienoic acids (EETs)) are part of the endothelial hyperpolarization factor and are vasodilators independent of nitric oxide. However, little is known regarding the regulation of EET concentration by docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) in blood vessels. Sprague-Dawley rats were fed either a control or fish oil diet for 3 weeks. Compared with the control, the fish oil diet improved acetylcholine-induced vasodilation and reduced the protein expression of soluble epoxide hydrolase (sEH), a key EET metabolic enzyme, in aortic strips...
June 24, 2017: Nutrients
https://www.readbyqxmd.com/read/28642117/soluble-epoxide-hydrolase-as-a-therapeutic-target-for-pain-inflammatory-and-neurodegenerative-diseases
#11
REVIEW
Karen M Wagner, Cindy B McReynolds, William K Schmidt, Bruce D Hammock
Eicosanoids are biologically active lipid signaling molecules derived from polyunsaturated fatty acids. Many of the actions of eicosanoid metabolites formed by cyclooxygenase and lipoxygenase enzymes have been characterized, however, the epoxy-fatty acids (EpFAs) formed by cytochrome P450 enzymes are newly described by comparison. The EpFA metabolites modulate a diverse set of physiologic functions that include inflammation and nociception among others. Regulation of EpFAs occurs primarily via release, biosynthesis and enzymatic transformation by the soluble epoxide hydrolase (sEH)...
June 19, 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28630842/irreducible-subtalar-dislocation-caused-by-sustentaculum-tali-incarceration
#12
Mourad Zaraa, Ismail Jerbi, Sabri Mahjoub, Heithem Sehli, Mondher Mbarek
INTRODUCTION: Subtalar dislocation is an uncommon lesion in traumatology chiefly when it concerns the lateral form. Surgical treatment is required when a fracture is related or the dislocation is irreducible. Even well treated, these dislocations progress unavoidably to subtalar arthrosis, which stays well tolerated. CASE REPORT: A 46-year-old male with irreducible lateral subtalar dislocation caused sustentaculum tali incarceration confirmed on computed tomography (CT)...
January 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28628578/neuraxial-anesthesia-in-obstetric-patients-receiving-thromboprophylaxis-with-unfractionated-or-low-molecular-weight-heparin-a-systematic-review-of-spinal-epidural-hematoma
#13
Lisa R Leffert, Heloise M Dubois, Alexander J Butwick, Brendan Carvalho, Timothy T Houle, Ruth Landau
Venous thromboembolism remains a major source of morbidity and mortality in obstetrics with an incidence of 29.8/100,000 vaginal delivery hospitalizations; cesarean delivery confers a 4-fold increased risk of thromboembolism when compared with vaginal delivery. Revised national guidelines now stipulate that the majority of women delivering via cesarean and women at risk for ante- or postpartum venous thromboembolism receive mechanical or pharmacological thromboprophylaxis. This practice change has important implications for obstetric anesthesiologists concerned about the risk of spinal epidural hematoma (SEH) among anticoagulated women receiving neuraxial anesthesia...
July 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28627772/bactericidal-effect-of-calcium-oxide-scallop-shell-powder-against-pseudomonas-aeruginosa-biofilm-on-quail-egg-shell-stainless-steel-plastic-and-rubber
#14
Soo-Jin Jung, Shin Young Park, Seh Eun Kim, Ike Kang, Jiyong Park, Jungwon Lee, Chang-Min Kim, Myung-Sub Chung, Sang-Do Ha
The aim of this study was to evaluate the bactericidal effect of calcium oxide (CaO) against Pseudomonas aeruginosa biofilms on quail eggshells and major egg contacting surfaces (stainless steel, plastic, and rubber). The samples were subjected to CaO treatments (0%, 0.01%, 0.05%, 0.10%, 0.15%, 0.20%, 0.25%, and 0.30%) for 1 min. All the CaO treatments significantly reduced P. aeruginosa biofilms on all tested surfaces as compared to controls. In comparison of biofilm stability, the strongest and most resistant biofilm was formed on eggshell against the CaO treatment, followed by rubber, stainless steel, and plastic...
June 19, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28600384/oxetane-substrates-of-human-microsomal-epoxide-hydrolase
#15
Francesca Toselli, Marlene Fredenwall, Peder Svensson, Xue-Qing Li, Anders Johansson, Lars Weidolf, Martin A Hayes
Oxetanyl building blocks are increasingly used in drug discovery because of the improved drug-like properties they confer on drug candidates, yet little is currently known about their biotransformation. A series of oxetane-containing analogs was studied and we provide the first direct evidence of oxetane hydrolysis by human recombinant microsomal epoxide hydrolase (mEH). Incubations with human liver fractions and hepatocytes were performed with and without inhibitors of cytochrome P450 (P450), mEH and soluble epoxide hydrolase (sEH)...
August 2017: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/28583889/a-diet-rich-in-omega-3-fatty-acids-enhances-expression-of-soluble-epoxide-hydrolase-in-murine-brain
#16
Annika Irmgard Ostermann, Martina Reutzel, Nicole Hartung, Nicole Franke, Laura Kutzner, Kirsten Schoenfeld, Karsten-Henrich Weylandt, Gunter Peter Eckert, Nils Helge Schebb
Several studies suggest that intake of omega-3 polyunsaturated fatty acids (n3-PUFA) beneficially influences cognitive function. However, effects on the adult brain are not clear. Little is known about the impact of dietary intervention on the fatty acid profile in adult brain, the modulation in the expression of enzymes involved in fatty acid biosynthesis and metabolism as well as changes in resulting oxylipins. These questions were addressed in the present study in two independent n3-PUFA feeding experiments in mice...
June 3, 2017: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/28577112/3d-qsar-molecular-dynamics-simulations-and-molecular-docking-studies-on-pyridoaminotropanes-and-tetrahydroquinazoline-as-mtor-inhibitors
#17
Udit Chaube, Hardik Bhatt
Cancer is a second major disease after metabolic disorders where the number of cases of death is increasing gradually. Mammalian target of rapamycin (mTOR) is one of the most important targets for treatment of cancer, specifically for breast and lung cancer. In the present research work, Comparative Molecular Field Analysis (CoMFA) and Comparative Molecular Similarity Indices Analysis (CoMSIA) studies were performed on 50 compounds reported as mTOR inhibitors. Three different alignment methods were used, and among them, distill method was found to be the best method...
June 2, 2017: Molecular Diversity
https://www.readbyqxmd.com/read/28574329/spinal-epidural-hematomas-personal-experience-and-literature-review-of-more-than-1000-cases
#18
Maurizio Domenicucci, Cristina Mancarella, Giorgio Santoro, Demo Eugenio Dugoni, Alessandro Ramieri, Maria Felice Arezzo, Paolo Missori
OBJECTIVE The goal of this study was to identify factors that contribute to the formation of acute spinal epidural hematoma (SEH) by correlating etiology, age, site, clinical status, and treatment with immediate results and long-term outcomes. METHODS The authors reviewed their series of 15 patients who had been treated for SEH between 1996 and 2012. In addition, the authors reviewed the relevant international literature from 1869 (when SEH was first described) to 2012, collecting a total of 1010 cases. Statistical analysis was performed in 959 (95%) cases that were considered valid for assessing the incidence of age, sex, site, and clinical status at admission, correlating each of these parameters with the treatment results...
June 2, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28552948/association-of-gain-of-function-ephx2-polymorphism-lys55arg-with-acute-kidney-injury-following-cardiac-surgery
#19
Megan M Shuey, Frederic T Billings, Shouzou Wei, Ginger L Milne, Hui Nian, Chang Yu, Nancy J Brown
Twenty to thirty percent of patients undergoing cardiac surgery develop acute kidney injury (AKI). In mice, inhibition of soluble epoxide hydrolase (sEH) attenuates renal injury following ischemia-reperfusion. We tested the hypothesis that functional variants of EPHX2, encoding sEH, are associated with AKI after cardiac surgery. We genotyped patients in two independent cardiac surgery cohorts for functional EPHX2 polymorphisms, Lys55Arg and Arg287Gln, and determined AKI using Acute Kidney Injury Network criteria...
2017: PloS One
https://www.readbyqxmd.com/read/28522175/pharmacological-inhibition-of-soluble-epoxide-hydrolase-or-genetic-deletion-reduces-diclofenac-induced-gastric-ulcers
#20
Sumanta Kumar Goswami, Amelia Ann Rand, Debin Wan, Jun Yang, Bora Inceoglu, Melany Thomas, Christophe Morisseau, Guang-Yu Yang, Bruce D Hammock
AIMS: This research was conducted to evaluate the hypothesis that gastric ulcers caused by the NSAID diclofenac sodium (DCF) can be prevented by the soluble epoxide hydrolase inhibitor TPPU. MAIN METHODS: Mice were administered a single dose of 10, 30 or 100mg/kg of DCF. Once an ulcerative dose of DCF was chosen, mice were pretreated with TPPU for 7days at 0.1mg/kg to evaluate anti-ulcer effects of the sEH inhibitor on anatomy, histopathology, pH, inflammatory markers and epithelial apoptosis of stomachs...
July 1, 2017: Life Sciences
keyword
keyword
9149
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"