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https://www.readbyqxmd.com/read/28943502/segmental-zoster-abdominal-paresis-zoster-pseudohernia-preceding-a-skin-rash
#1
Seh Hyun Park, Si-Hyung Lee
No abstract text is available yet for this article.
September 23, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/28935975/tumor-necrosis-factor-inducible-gene-6-protein-ameliorates-chronic-liver-damage-by-promoting-autophagy-formation-in-mice
#2
Sihyung Wang, Chanbin Lee, Jieun Kim, Jeongeun Hyun, Minso Lim, Hyuk-Jin Cha, Seh-Hoon Oh, Yung Hyun Choi, Youngmi Jung
Tumor necrosis factor-inducible gene 6 protein (TSG-6) has recently been shown to protect the liver from acute damage. However, the mechanism underlying the effect of TSG-6 on the liver remains unclear. Autophagy is a catabolic process that targets cell components to lysosomes for degradation, and its functions are reported to be dysregulated in liver diseases. Here we investigate whether TSG-6 promotes liver regeneration by inducing autophagic clearance in damaged livers. Mice fed a methionine choline-deficient diet supplemented with 0...
September 22, 2017: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/28935352/post-traumatic-cervical-spine-epidural-hematoma-incidence-and-risk-factors
#3
Pedro A Ricart, Ravi Verma, Steven J Fineberg, Kyle Y Fink, Paul A Lucas, Yungtai Lo, David E Asprinio, Louis F Amorosa
BACKGROUND: The incidence and risk factors for post-traumatic cervical epidural hematoma are not well described in the current literature. Our aim was to determine the incidence and associated risk factors for post-traumatic cervical spine epidural hematoma (SEH). METHODS: We performed a retrospective review of our institution's prospectively collected data submitted to the state trauma registry, using ICD-9 codes, for all patients activated as a trauma with cervical spine injuries, between the years 2010 and 2014...
August 30, 2017: Injury
https://www.readbyqxmd.com/read/28916003/genetic-diversity-and-antibiotic-susceptibility-of-staphylococcus-aureus-isolates-from-wild-boars
#4
D Seinige, A Von Altrock, C Kehrenberg
We here report the occurrence of S. aureus in wild boars and characterize isolates genotypically and phenotypically in order to get knowledge about the occurrence of clonal lineages and genotypes in free-living wild animals. Forty-one S. aureus isolates obtained from 111 wild boars hunted in Lower Saxony, Germany, were investigated and compared to human and livestock isolates. The S. aureus belonged to multilocus sequence types ST1, ST7, ST30, ST133, ST425, ST804, ST890 and to the new ST3237, ST3238, ST3255 and ST3369...
October 2017: Comparative Immunology, Microbiology and Infectious Diseases
https://www.readbyqxmd.com/read/28902194/elucidating-the-role-of-surface-passivating-ligand-structural-parameters-in-hole-wave-function-delocalization-in-semiconductor-cluster-molecules
#5
Meghan B Teunis, Mulpuri Nagaraju, Poulami Dutta, Jingzhi Pu, Barry B Muhoberac, Rajesh Sardar, Mangilal Agarwal
This article describes the mechanisms underlying electronic interactions between surface passivating ligands and (CdSe)34 semiconductor cluster molecules (SCMs) that facilitate band-gap engineering through the delocalization of hole wave functions without altering their inorganic core. We show here both experimentally and through density functional theory calculations that the expansion of the hole wave function beyond the SCM boundary into the ligand monolayer depends not only on the pre-binding energetic alignment of interfacial orbitals between the SCM and surface passivating ligands but is also strongly influenced by definable ligand structural parameters such as the extent of their π-conjugation [π-delocalization energy; pyrene (Py), anthracene (Anth), naphthalene (Naph), and phenyl (Ph)], binding mode [dithiocarbamate (DTC, -NH-CS2(-)), carboxylate (-COO(-)), and amine (-NH2)], and binding head group [-SH, -SeH, and -TeH]...
September 13, 2017: Nanoscale
https://www.readbyqxmd.com/read/28890385/reduced-coronary-reactive-hyperemia-in-mice-was-reversed-by-the-soluble-epoxide-hydrolase-inhibitor-t-aucb-role-of-adenosine-a2a-receptor-and-plasma-oxylipins
#6
Ahmad Hanif, Matthew L Edin, Darryl C Zeldin, Christophe Morisseau, John R Falck, Catherine Ledent, Stephen L Tilley, Mohammed A Nayeem
Coronary reactive hyperemia (CRH) protects the heart against ischemia. Adenosine A2AAR-deficient (A2AAR(-/-)) mice have increased expression of soluble epoxide hydrolase (sEH); the enzyme responsible for breaking down the cardioprotective epoxyeicosatrienoic acids (EETs) to dihydroxyeicosatrienoic acids (DHETs). sEH-inhibition enhances CRH, increases EETs, and modulates oxylipin profiles. We investigated the changes of oxylipins and their impact on CRH in A2AAR(-/-) and wild type (WT) mice. We hypothesized that the attenuated CRH in A2AAR(-/-) mice is mediated by changes in oxylipin profiles, and that it can be reversed by either sEH- or ω-hydroxylases-inhibition...
July 2017: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/28889263/chemical-speciation-of-selenium-and-mercury-as-determinant-of-their-neurotoxicity
#7
C S Oliveira, B C Piccoli, M Aschner, J B T Rocha
The antagonism of mercury toxicity by selenium has been well documented. Mercury is a toxic metal, widespread in the environment. The main target organs (kidneys, lungs, or brain) of mercury vary depending on its chemical forms (inorganic or organic). Selenium is a semimetal essential to mammalian life as part of the amino acid selenocysteine, which is required to the synthesis of the selenoproteins. This chapter has the aim of disclosing the role of selenide or hydrogen selenide (Se(-2) or HSe(-)) as central metabolite of selenium and as an important antidote of the electrophilic mercury forms (particularly, Hg(2+) and MeHg)...
2017: Advances in Neurobiology
https://www.readbyqxmd.com/read/28881620/eets-reduces-lps-induced-hyperpermeability-by-targeting-grp78-mediated-src-activation-and-subsequent-rho-rock-signaling-pathway
#8
Ruolan Dong, Danli Hu, Yan Yang, Zhihui Chen, Menglu Fu, Dao Wen Wang, Xizhen Xu, Ling Tu
Integrity of endothelial barrier is a determinant of the prognosis in the acute lung injury caused by sepsis. The epoxyeicosatrienoic acids (EETs), metabolites of arachidonic acid, exhibit protective effects in various pathogenic states, however, whether EETs play a role in endothelial barrier enhancement and the involved mechanisms remain to be investigated. Here, we show that increased EETs level by endothelial specific cytochrome P450 epoxygenase 2J2 over-expression and soluble epoxide hydrolase (sEH) inhibitor TPPU reduced lipopolysaccharide-induced endothelial hyper-permeability in vivo, accompanied by improved survival of septic mice...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28867792/soluble-epoxide-hydrolase-inhibitory-activity-of-components-isolated-from-apios-americana-medik
#9
Jang Hoon Kim, Hyo Young Kim, Si Yong Kang, Young Ho Kim, Chang Hyun Jin
A new compound 1, 5-methoxy-2,5,7,4'-tetrahydroxy-coumaronochromone, along with seven known compounds (2-8), were isolated from Apios americana using open column chromatography. Their structures were established based on an analysis of 1D and 2D NMR, and MS spectra. Among these, two compounds 1 and 2 showed inhibitory activity on soluble epoxide hydrolase (sEH) at a concentration below 50 μM. The respective competitive (1) and mixed (2) inhibitors were revealed to have Ki values of 21.0 ± 0.8 and 14.5 ± 1...
August 30, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28863368/postprandial-effect-to-decrease-soluble-epoxide-hydrolase-activity-roles-of-insulin-and-gut-microbiota
#10
Jun Yang, Young Taek Oh, Debin Wan, Richard M Watanabe, Bruce D Hammock, Jang H Youn
Epoxides of free fatty acids (FFAs), especially epoxyeicosatrienoic acids (EETs), are lipid mediators with beneficial effects in metabolic and cardiovascular (CV) health. FFA epoxides are quickly metabolized to biologically less active diols by soluble epoxide hydrolase (sEH). Inhibition of sEH, which increases EET levels, improves glucose homeostasis and CV health and is proposed as an effective strategy for the treatment of diabetes and CV diseases. Here, we show evidence that sEH activity is profoundly reduced in postprandial states in rats; plasma levels of 17 sEH products (i...
July 21, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28852822/incidence-and-risk-factors-for-symptomatic-spinal-epidural-haematoma-following-lumbar-spinal-surgery
#11
Jia-Ming Liu, Hui-Lin Deng, Yang Zhou, Xuan-Yin Chen, Dong Yang, Man-Sheng Duan, Shan-Hu Huang, Zhi-Li Liu
PURPOSE: Spinal epidural haematoma (SEH) is a common complication after lumbar spinal decompression surgery, and symptomatic SEH usually causes devastating neurological deficits. Although different risk factors for post-operative SEH have been reported, few studies focused on patients' laboratory tests. The purpose of this study was to analyze the incidence of symptomatic SEH following lumbar spinal surgery, as well as identify the risk factors for it. METHODS: Patients who underwent posterior lumbar spinal decompression surgery between January 2010 and August 2016 were included in this study and their medical records were retrospectively reviewed...
August 29, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28845983/a-dual-modulator-of-farnesoid-x-receptor-and-soluble-epoxide-hydrolase-to-counter-non-alcoholic-steatohepatitis
#12
Jurema Schmidt, Marco Rotter, Tim Weiser, Sandra K Wittmann, Lilia Weizel, Astrid Kaiser, Jan Heering, Tamara Goebel, Carlo Angioni, Mario Wurglics, Alexander Paulke, Gerd Geisslinger, Astrid Kahnt, Dieter Steinhilber, Ewgenij Proschak, Daniel Merk
Non-alcoholic steatohepatitis arising from western diet and lifestyle is characterized by accumulation of fat in liver causing inflammation and fibrosis. It evolves as serious health burden with alarming incidence but there is no satisfying pharmacological therapy to date. Considering the disease's multifactorial nature, modulation of multiple targets might provide superior therapeutic efficacy. In particular, farnesoid X receptor (FXR) activation that revealed anti-steatotic and anti-fibrotic effects in clinical trials combined with inhibition of soluble epoxide hydrolase (sEH) as anti-inflammatory strategy promises synergies...
August 28, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28840361/visual-word-recognition-and-vowelization-in-arabic-new-evidence-from-lexical-decision-task-performances
#13
Haitham Taha, Hanan Azaizah-Seh
The effect of vowelization signs on the process of visual word recognition in Arabic was investigated among 41 native Arab skilled readers with age average of 30.66 ± 9.09. The participants performed a lexical decision task using three types of words and pseudowords; full, partial and non-vowelized. The results showed that for both words and pseudowords, response times were shorter and accuracy levels were higher for the non-vowelized condition compared to the other conditions of vowelization. The results reinforce the argument that automatic lexical processes during word recognition in Arabic orthography might be disturbed by supplementary information such as vowelization...
August 24, 2017: Cognitive Processing
https://www.readbyqxmd.com/read/28839250/pharmacological-profile-and-efficiency-in-vivo-of-diflapolin-the-first-dual-inhibitor-of-5-lipoxygenase-activating-protein-and-soluble-epoxide-hydrolase
#14
Ulrike Garscha, Erik Romp, Simona Pace, Antonietta Rossi, Veronika Temml, Daniela Schuster, Stefanie König, Jana Gerstmeier, Stefanie Liening, Markus Werner, Heiner Atze, Sandra Wittmann, Christina Weinigel, Silke Rummler, Gerhard K Scriba, Lidia Sautebin, Oliver Werz
Arachidonic acid (AA) is metabolized to diverse bioactive lipid mediators. Whereas the 5-lipoxygenase-activating protein (FLAP) facilitates AA conversion by 5-lipoxygenase (5-LOX) to pro-inflammatory leukotrienes (LTs), the soluble epoxide hydrolase (sEH) degrades anti-inflammatory epoxyeicosatrienoic acids (EETs). Accordingly, dual FLAP/sEH inhibition might be advantageous drugs for intervention of inflammation. We present the in vivo pharmacological profile and efficiency of N-[4-(benzothiazol-2-ylmethoxy)-2-methylphenyl]-N'-(3,4-dichlorophenyl)urea (diflapolin) that dually targets FLAP and sEH...
August 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28839031/complete-sequence-of-a-staphylococcus-aureus-clonal-complex-81-strain-the-dominant-lineage-in-food-poisoning-outbreaks-in-japan
#15
Yusuke Sato'o, Junzo Hisatsune, Hideki Hirakawa, Hisaya K Ono, Katsuhiko Omoe, Motoyuki Sugai
Staphylococcus aureus No. 10 is an isolate from a staphylococcal food poisoning outbreak in Japan, classified as clonal complex 81 subtype 1. It preferentially produces larger quantities of staphylococcal enterotoxin A (SEA) and staphylococcal enterotoxin H (SEH) in foods and media. Here, we report the complete annotated genome sequence of the chromosome and a plasmid.
August 24, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28827330/cytochrome-p450-monooxygenase-lipid-metabolites-are-significant-second-messengers-in-the-resolution-of-choroidal-neovascularization
#16
Eiichi Hasegawa, Saori Inafuku, Lama Mulki, Yoko Okunuki, Ryoji Yanai, Kaylee E Smith, Clifford B Kim, Garrett Klokman, Diane R Bielenberg, Narender Puli, John R Falck, Deeba Husain, Joan W Miller, Matthew L Edin, Darryl C Zeldin, Kin Sing Stephen Lee, Bruce D Hammock, Wolf-Hagen Schunck, Kip M Connor
Age-related macular degeneration (AMD) is the most common cause of blindness for individuals age 50 and above in the developed world. Abnormal growth of choroidal blood vessels, or choroidal neovascularization (CNV), is a hallmark of the neovascular (wet) form of advanced AMD and leads to significant vision loss. A growing body of evidence supports a strong link between neovascular disease and inflammation. Metabolites of long-chain polyunsaturated fatty acids derived from the cytochrome P450 (CYP) monooxygenase pathway serve as vital second messengers that regulate a number of hormones and growth factors involved in inflammation and vascular function...
August 21, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28827137/a-novel-mechanism-of-ascorbate-direct-modulation-of-soluble-epoxide-hydrolase
#17
Bin Zhang, Sharath Kandhi, Yang-Ming Yang, Yicong Le, Wensheng Deng, Jun Qin, Houli Jiang, Ghezal Froogh, Dong Sun, An Huang
To test the hypothesis that VitC downregulates soluble epoxide hydrolase (sEH, responsible for converting EETs to DHETs) to stabilize tissue EETs, the heart, lung, liver, kidney, and mesenteric arteries isolated from normal rats were incubated with VitC (1000μM) for 72h, and tissue sEH expression, along with EET and DHET profiles were assessed. VitC caused significant reductions in sEH mRNA and protein content in the liver, heart and vessels, but had no effect on renal and pulmonary sEH expression, revealing a tissue-specific regulatory mechanism...
August 18, 2017: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/28822809/inhibition-of-soluble-epoxide-hydrolase-lowers-portal-hypertension-in-cirrhotic-rats-by-ameliorating-endothelial-dysfunction-and-liver-fibrosis
#18
Wensheng Deng, Yiming Zhu, Jiayun Lin, Lei Zheng, Chihao Zhang, Meng Luo
Epoxyeicostrienoic acids (EETs) are arachidonic acid derived meditators which are catalyzed by soluble epoxide hydrolase (sEH) to less active dihydroeicostrienoics acids (DHETS). The aim of our study is to investigate the effects of sEH inhibition on hepatic and systemic hemodynamics, hepatic endothelial dysfunction, and hepatic fibrosis in CCl4 cirrhotic rats. The sEH inhibitor,trans-4-{4-[3-(4-trifluoromethoxyphenyl)-ureido]cyclohexyloxy}benzoic acid (t-TUCB) was administered to stabilize hepatic EETs by gavage at a dose of 1mg/kg/d...
August 16, 2017: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/28822080/soluble-epoxide-hydrolase-inhibition-attenuates-mptp-induced-neurotoxicity-in-the-nigrostriatal-dopaminergic-system-involvement-of-%C3%AE-synuclein-aggregation-and-er-stress
#19
Hui-Ju Huang, Yi-Ting Wang, Hui-Ching Lin, Yi-Hsuan Lee, Anya Maan-Yuh Lin
Soluble epoxide hydrolase (sEH) is widely expressed in the mammalian brain and possesses dual enzymatic activities, including C-terminal epoxide hydrolase (C-EH) which degrades epoxyeicosatrienoic acid (EET), a beneficial arachidonic acid metabolite. In the present study, the neuroprotective effect of sEH inhibition on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurodegeneration of nigrostriatal dopaminergic system was investigated using genetic and pharmacological approaches. MPTP (15 mg/kg) was intraperitoneally injected in sEH knockout (KO) mice and C57BL/6J mice as wild-type (WT) mice...
August 18, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28798352/soluble-epoxide-hydrolase-inhibition-promotes-white-matter-integrity-and-long-term-functional-recovery-after-chronic-hypoperfusion-in-mice
#20
Yuxue Chen, Hao Tian, Ensheng Yao, Yeye Tian, Huaqiu Zhang, Li Xu, Zhiyuan Yu, Yongkang Fang, Wei Wang, Peng Du, Minjie Xie
Chronic cerebral hypoperfusion induced cerebrovascular white matter lesions (WMLs) are closely associated with cognitive impairment and other neurological deficits. The mechanism of demyelination in response to hypoperfusion has not yet been fully clarified. Soluble epoxide hydrolase (sEH) is an endogenous key enzyme in the metabolic conversion and degradation of P450 eicosanoids called epoxyeicosatrienoic acids. Inhibition of sEH has been suggested to represent a prototype "combination therapy" targeting multiple mechanisms of stroke injury with a single agent...
August 10, 2017: Scientific Reports
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