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https://www.readbyqxmd.com/read/29777044/the-impact-of-sign-glaucoma-guidelines-on-false-positive-referrals-from-community-optometrists-in-central-scotland
#1
Samantha Sii, Ahmad Nasser, Cheng Yi Loo, Catherine Croghan, Alan Rotchford, Pankaj Kumar Agarwal
BACKGROUND: Since the introduction of National Institute for Health and Care Excellence glaucoma guidelines 2009, the number of referrals from community optometrists to hospital eye services has increased across the UK, resulting in increase in first visit discharge rates (FVDRs). AIM: To assess the impact of Scottish Intercollegiate Guidelines Network (SIGN) 144 on quality of referrals from community optometrists. METHODOLOGY: A retrospective study of patient records who attended as new adult glaucoma referrals to clinics in Princess Alexandra Eye Pavilion, Edinburgh, and in Greater Glasgow and Clyde, was carried out across October-November 2014 (group 1) and September-October 2016 (group 2), before and after the introduction of SIGN 144...
May 18, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29761140/hearing-impairment-among-children-referred-to-a-public-audiology-clinic-in-gaborone-botswana
#2
Francis M Banda, Kathleen M Powis, Agnes B Mokoka, Moalosi Mmapetla, Katherine D Westmoreland, Thuso David, Andrew P Steenhoff
Objective . To describe and quantify hearing impairment among children referred to the audiology clinic in Princess Marina Hospital, a public referral hospital in Botswana. Methods . In a retrospective case series, we reviewed medical records of children aged 10 years and younger whose hearing was assessed between January 2006 and December 2015 at the audiology clinic of Princess Marina Hospital in Gaborone, Botswana. Results . Of 622 children, 50% were male, and median age was 6.7 years (interquartile range = 5...
2018: Global Pediatric Health
https://www.readbyqxmd.com/read/29758220/evaluation-of-an-aggressive-prostate-biopsy-strategy-in-men-younger-than-50-years-of-age
#3
Hanan Goldberg, Zachary Klaassen, Thenappan Chandrasekar, Christopher J D Wallis, Ants Toi, Rashid Sayyid, Bimal Bhindi, Michael Nesbitt, Andrew Evans, Theo van der Kwast, Joan Sweet, Nathan Perlis, Robert J Hamilton, Girish S Kulkarni, Antonio Finelli, Alexandre Zlotta, Neil Fleshner
INTRODUCTION: Longitudinal cohort studies and guidelines demonstrate that PSA ≥1 ng/mL in younger patients confer an increased risk of delayed prostate cancer (PC) death. In our institution we have used an aggressive biopsy strategy among younger patients with PSA of>1 ng/ml. Our objective was to determine the proportion of detected cancer and specifically, clinical significant cancer, with this strategy. METHODS: The prostate biopsy (PB) database at Princess Margaret Cancer Centre was queried for patients younger than 50 who underwent a first PB between 2000 and 2016...
May 11, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29736088/the-princess-of-polka-dots-using-art-as-a-medium-to-cope-with-hallucinations
#4
K V Suma, Suhas Chandran, T S Sathyanarayana Rao
No abstract text is available yet for this article.
January 2018: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/29731949/stevens-johnson-syndrome-and-toxic-epidermal-necrolysis-extensive-review-of-reports-of-drug-induced-etiologies-and-possible-therapeutic-modalities
#5
REVIEW
Adegbenro Omotuyi John Fakoya, Princess Omenyi, Precious Anthony, Favour Anthony, Precious Etti, David Adeiza Otohinoyi, Esther Olunu
Stevens - Johnson Syndrome and Toxic Epidermal Necrolysis are adverse hypersensitivity reactions that affect the skin and mucous membranes. They are characterised by erythematous macules and hemorrhagic erosions of the mucous membranes. Epidermal detachments of varying degrees of severity also occur in these conditions. Various aetiologies are associated with these conditions, with adverse drug reaction being the most common. Though the worldwide incidence of these conditions is recorded as low, diverse types of medication are being observed to lead to these conditions...
April 15, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29731750/macrophage-lamin-a-c-regulates-inflammation-and-the-development-of-obesity-induced-insulin-resistance
#6
Youngjo Kim, Princess Wendy Bayona, Miri Kim, Jiyeon Chang, Sunmin Hong, Yoona Park, Andrea Budiman, Yong-Jin Kim, Chang Yong Choi, Woo Seok Kim, Jongsoon Lee, Kae Won Cho
Obesity-induced chronic low-grade inflammation, in particular in adipose tissue, contributes to the development of insulin resistance and type 2 diabetes. However, the mechanism by which obesity induces adipose tissue inflammation has not been completely elucidated. Recent studies suggest that alteration of the nuclear lamina is associated with age-associated chronic inflammation in humans and fly. These findings led us to investigate whether the nuclear lamina regulates obesity-mediated chronic inflammation...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29720009/interprofessional-learning-experiences-exploring-the-perception-and-attitudes-of-saudi-arabian-medical-and-dental-students
#7
Ghadeer K Al-Shaikh, Ebtissam M Al-Madi, Jazba Masood, Quratulain Shaikh, Sadiqa B Syed, Rima S Bader, Judy McKimm
OBJECTIVE: The objective of this study is to evaluate the awareness and attitudes of medical and dental students regarding interprofessional learning (IPL). METHODS: A cross-sectional study was conducted with 278 female undergraduate Medical and Dental students from Princess Nourah bint Abdulrahman University, Riyadh. These students undertook IPL in the Foundation block, in basic science teaching, clinical skills' laboratories and in professionalism and learning skills' modules...
May 2, 2018: Medical Teacher
https://www.readbyqxmd.com/read/29708483/sexual-behaviour-hpv-status-and-p16-ink4a-expression-in-oropharyngeal-and-oral-cavity-squamous-cell-carcinomas-a-case-case-comparison-study
#8
Sarah Emmett, Samuel Boros, David C Whiteman, Sandro V Porceddu, Benedict J Panizza, Annika Antonsson
A significant proportion of mucosal squamous cell carcinomas of the head and neck (HNSCC; particularly of the oropharynx) are directly attributable to the human papillomavirus (HPV). The increase in the incidence of HPV-related tumours has been postulated to be due to changing sexual practices in the community. We analysed 136 formalin-fixed paraffin-embedded squamous cell carcinomas from the oral cavity (n=40) and oropharynx (n=96) recruited from the Princess Alexandra Hospital (Brisbane, Australia). Samples were analysed for the presence of HPV DNA using a combination of mucosal HPV general primer GP+ PCR and sequencing; p16INK4a expression was assessed by immunohistochemistry...
April 30, 2018: Journal of General Virology
https://www.readbyqxmd.com/read/29705243/a-kindred-with-mutant-ikaros-and-autoimmunity
#9
Erika Van Nieuwenhove, Josselyn E Garcia-Perez, Christine Helsen, Princess D Rodriguez, Pauline A van Schouwenburg, James Dooley, Susan Schlenner, Mirjam van der Burg, Els Verhoeyen, Rik Gijsbers, Seth Frietze, Hilde Schjerven, Isabelle Meyts, Frank Claessens, Stephanie Humblet-Baron, Carine Wouters, Adrian Liston
IKAROS (encoded by IKZF1) is an important hematopoietic transcription factor critical for early B cell differentiation, with major defects known to lead to low B cell numbers and hypogammaglobulinemia. More perplexing is the link between IKZF1 variants and autoimmunity, including polymorphisms associated with susceptibility to SLE, and recently, rare variants driving monogenic autoimmunity. We identified a novel p.L188V mutation in IKZF1 in the index patient and her father and found this mutation to lead to loss of DNA binding...
April 26, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29694300/representations-of-same-sex-relationships-between-female-characters-in-all-ages-comics-princess-princess-ever-after-and-lumberjanes
#10
Erica Gillingham
Representations of lesbian, gay, bisexual, transgender, and queer (LGBTQ) characters in comics for an all-ages readership have emerged in the United States in the early twenty-first century. This essay examines the narrative constructions of same-sex relationships between female characters in two all-ages speculative fiction comics, Princess Princess Ever After by Katie O'Neill, and Lumberjanes, created by Shannon Watters, Grace Ellis, Noelle Stevenson, and Brooke Allen.
April 25, 2018: Journal of Lesbian Studies
https://www.readbyqxmd.com/read/29678750/specific-igg-4-antibodies-to-cow-s-milk-proteins-in-pediatric-eosinophilic-esophagitis
#11
Alexander J Schuyler, Jeffrey M Wilson, Anubha Tripathi, Scott P Commins, Princess U Ogbogu, Patrice G Kruzsewski, Barrett H Barnes, Emily C McGowan, Lisa J Workman, Jonas Lidholm, Sheryl L Rifas-Shiman, Emily Oken, Diane R Gold, Thomas A E Platts-Mills, Elizabeth A Erwin
BACKGROUND: Allergen-specific IgG4 antibodies are often associated with tolerance, but specific IgG4 antibodies (sIgG4 ) to causally relevant foods have recently been reported in adult eosinophilic esophagitis (EoE). Prevalence and levels of food-sIgG4 are not well established in the general pediatric population. OBJECTIVE: We sought to investigate serum food-sIgG4 with component diagnostics in children with EoE and children from an unselected birth cohort and to explore the effects of sex, age and milk consumption on sIgG4 levels METHODS: Sera from 71 cases of pediatric EoE and 210 early-adolescent children from an unselected birth cohort (Project Viva) were assayed for sIgG4 and specific IgE (sIgE) to major cow's milk (CM) proteins (α-lactalbumin, β-lactoglobulin, caseins) and to wheat, soy, egg, and peanut proteins...
April 17, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29676948/perceptions-of-continued-smoking-and-smoking-cessation-among-patients-with-cancer
#12
Devon Alton, Lawson Eng, Lin Lu, Yuyao Song, Jie Su, Delaram Farzanfar, Rahul Mohan, Olivia Krys, Katie Mattina, Christopher Harper, Sophia Liu, Tom Yoannidis, Robin Milne, M Catherine Brown, Ashlee Vennettilli, Andrew J Hope, Doris Howell, Jennifer M Jones, Peter Selby, Wei Xu, David P Goldstein, Geoffrey Liu, Meredith E Giuliani
PURPOSE: Continued smoking after a cancer diagnosis leads to poorer treatment outcomes, survival, and quality of life. We evaluated the perceptions of the effects of continued smoking on quality of life, survival, and fatigue among patients with cancer after a cancer diagnosis and the effects of these perceptions on smoking cessation. PATIENTS AND METHODS: Patients with cancer from all disease subsites from Princess Margaret Cancer Centre (Toronto, Ontario) were surveyed between April 2014 and May 2016 for sociodemographic variables, smoking history, and perceptions of continued smoking on quality of life, survival, and fatigue...
May 2018: Journal of Oncology Practice
https://www.readbyqxmd.com/read/29667284/to-stent-or-not-to-stent-the-use-of-transanastomotic-biliary-stents-in-liver-transplantation-and-patient-outcomes
#13
Michelle Ong, Kellee Slater, Peter Hodgkinson, Nathan Dunn, Jonathan Fawcett
BACKGROUND: There is no substantial evidence for the use of biliary stents in bile duct reconstruction during liver transplantation. METHOD: A longitudinal, retrospective cohort study was performed to compare biliary complications between stented and non-stented patients between 2011 and 2015 at the Princess Alexandra Hospital, Brisbane, Australia. RESULTS: We found no significant difference in biliary complications between stented and non-stented groups...
April 17, 2018: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29664911/hpv-relatedness-definitions-for-classifying-hpv-related-oropharyngeal-cancer-patient-do-impact-on-tnm-classification-and-patients-survival
#14
Miren Taberna, Marisa Mena, Sara Tous, Miquel Angel Pavón, Marc Oliva, Xavier León, Jacinto Garcia, Marta Guix, Rafael Hijano, Teresa Bonfill, Antón Aguilà, Laia Alemany, Ricard Mesía
BACKGROUND: Given the different nature and better outcomes of oropharyngeal carcinoma (OPC) associated with human papillomavirus (HPV) infection, a novel clinical stage classification for HPV-related OPC has been accepted for the 8th edition AJCC TNM (ICON-S model). However, it is still unclear the HPV-relatedness definition with best diagnostic accuracy and prognostic value. MATERIAL AND METHODS: The aim of this study was to compare different staging system models proposed for HPV-related OPC patients: 7th edition AJCC TNM, RPA stage with non-anatomic factors (Princess Margaret), RPA with N categories for nasopharyngeal cancer (MD-Anderson) and AHR-new (ICON-S), according to different HPV-relatedness definitions: HPV-DNA detection plus an additional positive marker (p16INK4a or HPV-mRNA), p16INK4a positivity alone or the combination of HPV-DNA/p16INK4a positivity as diagnostic tests...
2018: PloS One
https://www.readbyqxmd.com/read/29656555/bibbidi-bobbidi-bald-two-hairowing-tales-of-princess-package-hairstyles
#15
Bree Zimmerman, Marta Ivars, Kelly M Cordoro
We present cases of localized alopecia on the vertex scalp of two girls after elaborate professional hairstyling marketed as the "Princess Package" at a major U.S. theme park. Localized alopecia followed pain, erythema, and delayed crusting due to necrosis of the scalp. The majority of the affected alopecic areas had evidence of regrowth at interval follow-up, but small areas of scarring alopecia remained. We propose that these cases represent a type of alopecia caused by a combination of pressure ischemia and acute traction alopecia...
April 15, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29652531/adult-narratives-of-the-psychosocial-impact-of-cleft-in-a-western-australian-cohort
#16
Wendy Nicholls, Martin Persson, Suzanne Robinson, Linda Selvey
BACKGROUND: Living with a cleft condition involves many years of multidisciplinary therapy, treatment, and surgical intervention. This complex process may have both physical and psychosocial long-term impacts. There is limited evidence of the psychosocial impact of cleft on individuals in Australia. AIM: To obtain an understanding of the adult patient perception of having a cleft and explore the impact of the condition on their lives. DESIGN: Qualitative methodologies at one case study site in Western Australia...
January 1, 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29626666/filtering-nucleotide-sites-by-phylogenetic-signal-to-noise-ratio-increases-confidence-in-the-neoaves-phylogeny-generated-from-ultraconserved-elements
#17
Princess S Gilbert, Jing Wu, Margaret W Simon, Janet S Sinsheimer, Michael E Alfaro
Despite genome scale analyses, high-level relationships among Neoaves birds remain contentious. The placements of the Neoaves superorders are notoriously difficult to resolve because they involve deep splits followed by short internodes. Using our approach, we investigate whether filtering UCE loci on their phylogenetic signal to noise ratio helps to resolve key nodes in the Neoaves tree of life. We find that our analysis of data sets filtered for high signal to noise ratio results in topologies that are inconsistent with unfiltered results but that are congruent with whole-genome analyses...
April 4, 2018: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/29620916/adult-specific-life-outcomes-of-cleft-lip-and-palate-in-a-western-australian-cohort
#18
Wendy Nicholls, Craig Harper, Suzanne Robinson, Martin Persson, Linda Selvey
BACKGROUND: People with a cleft of the lip and/or palate (CL/P) differ from their peers due to their facial appearance, hearing and speech difficulties, and the significant time spent attending appointments and recovering from surgical interventions. These differences may impact life outcomes including occupation, income, education, relationships, psychosocial health issues, and lifestyle choices. METHODOLOGY: A self-administered questionnaire was posted to 338 former and current patients of the Cleft Lip and Palate Unit of Princess Margaret Hospital (PMH), Perth, Western Australia...
January 1, 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29561882/effect-of-developmental-nmdar-antagonism-with-cgp-39551-on-aspartame-induced-hypothalamic-and-adrenal-gene-expression
#19
Kate S Collison, Angela Inglis, Sherin Shibin, Soad Saleh, Bernard Andres, Rosario Ubungen, Jennifer Thiam, Princess Mata, Futwan A Al-Mohanna
RATIONALE: Aspartame (L-aspartyl phenylalanine methyl ester) is a non-nutritive sweetener (NNS) approved for use in more than 6000 dietary products and pharmaceuticals consumed by the general public including adults and children, pregnant and nursing mothers. However a recent prospective study reported a doubling of the risk of being overweight amongst 1-year old children whose mothers consumed NNS-sweetened beverages daily during pregnancy. We have previously shown that chronic aspartame (ASP) exposure commencing in utero may detrimentally affect adulthood adiposity status, glucose metabolism and aspects of behavior and spatial cognition, and that this can be modulated by developmental N-methyl-D-aspartate receptor (NMDAR) blockade with the competitive antagonist CGP 39551 (CGP)...
2018: PloS One
https://www.readbyqxmd.com/read/29549211/role-of-viral-and-bacterial-pathogens-in-causing-pneumonia-among-western-australian-children-a-case-control-study-protocol
#20
Mejbah Uddin Bhuiyan, Thomas L Snelling, Rachel West, Jurissa Lang, Tasmina Rahman, Meredith L Borland, Ruth Thornton, Lea-Ann Kirkham, Chisha Sikazwe, Andrew C Martin, Peter C Richmond, David W Smith, Adam Jaffe, Christopher C Blyth
INTRODUCTION: Pneumonia is the leading cause of childhood morbidity and mortality globally. Introduction of the conjugate Haemophilus influenzae B and multivalent pneumococcal vaccines in developed countries including Australia has significantly reduced the overall burden of bacterial pneumonia. With the availability of molecular diagnostics, viruses are frequently detected in children with pneumonia either as primary pathogens or predispose to secondary bacterial infection. Many respiratory pathogens that are known to cause pneumonia are also identified in asymptomatic children, so the true contribution of these pathogens to childhood community-acquired pneumonia (CAP) remains unclear...
March 16, 2018: BMJ Open
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