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https://www.readbyqxmd.com/read/28921401/experience-with-curative-radiotherapy-for-cervix-cancer-in-the-bahamas-for-2006-2016
#1
Glenn Jones, Osama Kellini, Nevein Girgis, Darron Halliday, Raleigh Butler, Thomas McGowan, Conville Brown
BACKGROUND: Cervix cancer is a significant health problem. As access to quality care in Small Island Developing States improves, and cancer centers become established, providers of care can summarize local experience to benchmark system quality and look for ways to further improve value. METHODS: This is a retrospective study of all cases of cervix cancer managed 2006-2016 at The Cancer Centre Bahamas, in conjunction with Princess Margaret Hospital, Nassau, affiliated with The University of West Indies...
September 18, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28874902/lymph-node-retrieval-rates-in-melanoma-a-quality-assessment-parameter
#2
D Berger-Richardson, E Cordeiro, M Ernjakovic, A M Easson
INTRODUCTION: Regional lymph node dissection (rlnd) for melanoma with nodal metastasis is a specialized procedure that is associated with improved disease-specific survival in selected patients. Furthermore, there is evidence that a higher lymph node retrieval rate (lnrr) is associated with improved local control. Currently, no consensus has been reached on the definition of an adequate lnrr. A minimum lnrr has been proposed as a quality assessment parameter that has to be validated. METHODS: We conducted a retrospective cohort analysis at the Princess Margaret Cancer Centre (University Health Network, Toronto, ON)...
August 2017: Current Oncology
https://www.readbyqxmd.com/read/28870202/an-assessment-of-healthcare-professionals-knowledge-about-and-attitude-towards-influenza-vaccination-in-freetown-sierra-leone-a-cross-sectional-study
#3
Peter Bai James, Inayat Ur Rehman, Abudulai Jawo Bah, Michael Lahai, Christine Princess Cole, Tahir Mehmood Khan
BACKGROUND: Vaccinating healthcare professionals against influenza is considered an effective infection control measure. However, there is a low uptake of influenza vaccine among healthcare professionals around the globe. Currently, it is unknown whether healthcare professionals in Sierra Leone are aware of, and have been vaccinated against influenza. Also, there is a paucity of research evidence on their level of knowledge and attitude toward influenza vaccination. This study assessed healthcare professionals' current influenza vaccine uptake rate, reasons for not getting vaccinated as well as their awareness, knowledge of, and attitude towards influenza vaccination in Freetown Sierra Leone...
September 5, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28838393/prognostic-and-predictive-effects-of-tp53-co-mutation-in-patients-with-egfr-mutated-non-small-cell-lung-cancer-nsclc
#4
Catherine Labbé, Michael Cabanero, Grzegorz J Korpanty, Pascale Tomasini, Mark K Doherty, Céline Mascaux, Kevin Jao, Bethany Pitcher, Rick Wang, Melania Pintilie, Natasha B Leighl, Ronald Feld, Geoffrey Liu, Penelope Ann Bradbury, Suzanne Kamel-Reid, Ming-Sound Tsao, Frances A Shepherd
INTRODUCTION: TP53 mutations are common in non-small cell lung cancer (NSCLC) and have been reported as prognostic of poor outcome. The impact of TP53 co-mutations in epidermal growth factor receptor (EGFR)-mutated NSCLC is unclear. MATERIALS AND METHODS: Tissue from 105 patients with EGFR-mutated NSCLC at Princess Margaret Cancer Centre was analyzed by next-generation or Sanger sequencing to determine TP53 mutational status. Associations between TP53 status and baseline patient and tumor characteristics, treatments and outcomes (relapse-free survival [RFS] after surgical resection, overall survival [OS], overall response rate [ORR] and progression-free survival [PFS] on EGFR tyrosine kinase inhibitors [TKIs]), were investigated...
September 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28794386/overview-of-the-81-st-annual-scientific-meeting-of-the-japanese-circulation-society%C3%A3-cardiovascular-medicine-for-the-next-generation
#5
Noboru Fujino, Tsuyoshi Yoshimuta, Fukiko Ichida, Koichiro Kinugawa, Kazuo Usuda, Michihiko Kitayama, Hidekazu Ino, Masa-Aki Kawashiri, Hiroshi Tada, Sumio Mizuno, Kenshi Hayashi, Hirofumi Takemura, Masakazu Yamagishi
The 81(st)Annual Scientific Meeting of the Japanese Circulation Society was held in Kanazawa, Japan, on March 17-19, 2017 under a miraculously clear sky. The frontlines of healthcare and medicine are dramatically changing. Thus, "Cardiovascular Medicine for Next Generation" was chosen as the main theme of this meeting. The program was constructed around major identified issues, including renewal of our understanding of basic cardiovascular medicine, translational research, and preventive molecular medicine, all of which are anticipated to transcend the medical field over the next generation...
August 8, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28768678/a-concept-map-of-death-related-anxieties-in-patients-with-advanced-cancer
#6
Sigrun Vehling, Carmine Malfitano, Joanna Shnall, Sarah Watt, Tania Panday, Aubrey Chiu, Anne Rydall, Camilla Zimmermann, Sarah Hales, Gary Rodin, Christopher Lo
OBJECTIVES: Fear of death and dying is common in patients with advanced cancer, but can be difficult to address in clinical conversations. We aimed to show that the experience of death anxiety may be deconstructed into a network of specific concerns and to provide a map of their interconnections to aid clinical exploration. METHODS: We studied a sample of 382 patients with advanced cancer recruited from outpatient clinics at the Princess Margaret Cancer Centre, Toronto, Canada...
August 2, 2017: BMJ Supportive & Palliative Care
https://www.readbyqxmd.com/read/28741175/a-randomized-phase-ii-trial-of-geriatric-assessment-and-management-for-older-cancer-patients
#7
Martine T E Puts, Schroder Sattar, Michael Kulik, Mary Ellen MacDonald, Kara McWatters, Katherine Lee, Sarah Brennenstuhl, Raymond Jang, Eitan Amir, Monika K Krzyzanowska, Anthony M Joshua, Johanne Monette, Doreen Wan-Chow-Wah, Shabbir M H Alibhai
PURPOSE: Geriatric assessment and management (GAM) can identify current health issues and recommend interventions to optimize well-being of older adults, but no randomized trial has yet been completed in oncology. Therefore, a randomized phase 2 trial was conducted. METHODS: A two-group parallel single-blinded randomized phase II trial ( ClinicalTrials.gov Identifier: NCT02222259) enrolled patients aged ≥70 years, diagnosed with stage 2-4 gastrointestinal, genitourinary, or breast cancer within 6 weeks of commencing chemotherapy at Princess Margaret Cancer Centre...
July 25, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28736057/regional-variation-in-breast-cancer-surgery-results-from-the-national-cancer-database-ncdb
#8
Alexander S Chiu, Princess Thomas, Brigid K Killelea, Nina Horowitz, Anees B Chagpar, Donald R Lannin
BACKGROUND: Early studies have shown significant regional differences in the utilization of breast-conserving therapy (BCT) and mastectomy with reconstruction. It is expected that with the passage of time and the adoption of national treatment guidelines, these disparities would disappear. METHODS: Patients with non-metastatic breast cancer who underwent surgery between 2004 and 2013 were analyzed using the National Cancer Database (NCDB). Trends in BCT and reconstruction were evaluated and multivariate logistic regression performed...
July 18, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28705596/isolation-and-characterization-of-aerobic-anoxygenic-phototrophs-from-exposed-soils-from-the-s%C3%A3-r-rondane-mountains-east-antarctica
#9
Guillaume Tahon, Anne Willems
This study investigated the culturable aerobic phototrophic bacteria present in soil samples collected in the proximity of the Belgian Princess Elisabeth Station in the Sør Rondane Mountains, East Antarctica. Until recently, only oxygenic phototrophic bacteria (Cyanobacteria) were well known from Antarctic soils. However, more recent non-cultivation-based studies have demonstrated the presence of anoxygenic phototrophs and, particularly, aerobic anoxygenic phototrophic bacteria in these areas. Approximately 1000 isolates obtained after prolonged incubation under different growth conditions were studied and characterized by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry...
June 27, 2017: Systematic and Applied Microbiology
https://www.readbyqxmd.com/read/28701847/melioidosis-an-emerging-infection-with-fatal-outcomes
#10
Isabella Princess, R Ebenezer, Nagarajan Ramakrishnan, Arun Kumar Daniel, S Nandini, M A Thirunarayan
According to the Centers for Disease Control and Prevention, from being nonendemic for melioidosis, India has now become endemic for the disease since 2012. Until then, melioidosis cases were being reported sporadically from India. There have been isolated case reports from few states across the country for the past few years. Most of the times, Burkholderia pseudomallei may be misreported as Pseudomonas species, especially in resource-poor laboratories. Due to its varied clinical presentation, the specific clinical diagnosis can be difficult, thereby making laboratory diagnosis mandatory...
June 2017: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28700296/princess-diana-and-reduced-traffic-deaths-in-france-and-the-united-states
#11
Donald A Redelmeier, Junaid A Bhatti
No abstract text is available yet for this article.
August 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28660153/vascular-diseases-of-the-spleen-a-review
#12
REVIEW
Pearl Princess D Uy, Denise Marie Francisco, Anshu Trivedi, Michael O'Loughlin, George Y Wu
Vascular diseases of the spleen are relatively uncommon in the clinical practice. However, the reported incidence has been progressively increasing, probably due to advances in the imaging modalities used to detect them. This disease condition often presents with non-specific clinical manifestations, but can be associated with significant morbidity and mortality. This review article aims to provide updated clinical information on the different vascular diseases of the splenic vasculature-splenic vein thrombosis, splenic vein aneurysm, splenic artery aneurysm, splenic arteriovenous fistula, and spontaneous splenorenal shunt-in order to aid clinicians in early diagnosis and management...
June 28, 2017: Journal of Clinical and Translational Hepatology
https://www.readbyqxmd.com/read/28647247/spatial-variability-and-possible-sources-of-acetate-and-formate-in-the-surface-snow-of-east-antarctica
#13
Gautami Samui, Runa Antony, Kanthanathan Mahalinganathan, Meloth Thamban
Spatial trends of acetate (Ac(-)) and formate (Fo(-)) were determined in surface snow samples along a coastal-inland transect (180km) in the ice cap region at Princess Elizabeth Land and along a coastal transect in the Amery Ice Shelf (130km), East Antarctica. Variations in both Ac(-) and Fo(-) seem to be unrelated to the acidity of snow. Ionic balance determined for the snow samples indicate the availability of HNO3 that could undergo photolysis to produce hydroxyl radical (OH), one of the major reactants involved in oxidation reactions with organic matter...
July 2017: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/28637367/parental-perceptions-of-hypothermia-treatment-for-neonatal-hypoxic-ischaemic-encephalopathy
#14
Balamurugan Thyagarajan, Vijay Baral, Ranjit Gunda, Denise Hart, Lisa Leppard, Brigitte Vollmer
AIMS: Hypothermia Treatment (HT) is now the standard care for neonatal hypoxic-ischaemic encephalopathy (HIE). We conducted a survey to explore parental perceptions of HT as there is little information about this in the current literature. METHODS: Postal questionnaire survey included families (n = 51) whose babies received HT at Princess Anne Hospital, Southampton, UK, with 23 questions covering communication, clinical management, follow-up, and care in general...
July 11, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28630177/integrated-genome-and-transcriptome-sequencing-identifies-a-noncoding-mutation-in-the-genome-replication-factor-donson-as-the-cause-of-microcephaly-micromelia-syndrome
#15
Gilad D Evrony, Dwight R Cordero, Jun Shen, Jennifer N Partlow, Timothy W Yu, Rachel E Rodin, R Sean Hill, Michael E Coulter, Anh-Thu N Lam, Divya Jayaraman, Dianne Gerrelli, Diana G Diaz, Chloe Santos, Victoria Morrison, Antonella Galli, Ulrich Tschulena, Stefan Wiemann, M Jocelyne Martel, Betty Spooner, Steven C Ryu, Princess C Elhosary, Jillian M Richardson, Danielle Tierney, Christopher A Robinson, Rajni Chibbar, Dana Diudea, Rebecca Folkerth, Sheldon Wiebe, A James Barkovich, Ganeshwaran H Mochida, James Irvine, Edmond G Lemire, Patricia Blakley, Christopher A Walsh
While next-generation sequencing has accelerated the discovery of human disease genes, progress has been largely limited to the "low hanging fruit" of mutations with obvious exonic coding or canonical splice site impact. In contrast, the lack of high-throughput, unbiased approaches for functional assessment of most noncoding variants has bottlenecked gene discovery. We report the integration of transcriptome sequencing (RNA-seq), which surveys all mRNAs to reveal functional impacts of variants at the transcription level, into the gene discovery framework for a unique human disease, microcephaly-micromelia syndrome (MMS)...
August 2017: Genome Research
https://www.readbyqxmd.com/read/28622406/building-bridges-to-address-health-disparities-in-puerto-rico-the-salud-para-pi%C3%A3-ones-project
#16
Enid J García-Rivera, Princess Pacheco, Marielis Colón, Mary Helen Mays, Maricruz Rivera, Verónica Munet-Díaz, María Del R González, María Rodríguez, Rebecca Rodríguez, Astrid Morales
Over the past several decades, Puerto Ricans have faced increased health threats from chronic diseases, particularly diabetes and hypertension. The patient-provider relationship is the main platform for individual disease management, whereas the community, as an agent of change for the community's health status, has been limited in its support of individual health. Likewise, traditional research approaches within communities have placed academic researchers at the center of the process, considering their knowledge was of greater value than that of the community...
June 2017: Puerto Rico Health Sciences Journal
https://www.readbyqxmd.com/read/28600529/synthesis-chemical-characterization-and-multiscale-biological-evaluation-of-a-dimeric-crgd-peptide-for-targeted-imaging-of-%C3%AE-v-%C3%AE-3-integrin-activity
#17
Jamila Hedhli, Andrzej Czerwinski, Matthew Schuelke, Agata Płoska, Paweł Sowinski, Lukas La Hood, Spencer B Mamer, John A Cole, Paulina Czaplewska, Maciej Banach, Iwona T Dobrucki, Leszek Kalinowski, Princess Imoukhuede, Lawrence W Dobrucki
Cyclic peptides containing the Arg-Gly-Asp (RGD) sequence have been shown to specifically bind the angiogenesis biomarker α V β 3 integrin. We report the synthesis, chemical characterization, and biological evaluation of two novel dimeric cyclic RGD-based molecular probes for the targeted imaging of α V β 3 activity (a radiolabeled version, (64)Cu-NOTA-PEG4-cRGD2, for PET imaging, and a fluorescent version, FITC-PEG4-cRGD2, for in vitro work). We investigated the performance of this probe at the receptor, cell, organ, and whole-body levels, including its use to detect diabetes associated impairment of ischemia-induced myocardial angiogenesis...
June 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28589804/a-royal-turning-point
#18
Ian Hulatt
In disclosing the mental distress he experienced after the death of his mother Princess Diana, Prince Harry has joined a growing number of famous people who have felt enabled to make such issues public.
June 7, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28539305/deconstructing-cancer-patient-information-seeking-in-a-consumer-health-library-toward-developing-a-virtual-information-consult-for-cancer-patients-and-their-caregivers-a-qualitative-instrumental-case-study
#19
Janet Papadakos, Aileen Trang, Alaina B Cyr, Nazek Abdelmutti, Meredith E Giuliani, Michelle Snow, Tara McCurdie, Menaka Pulandiran, Sara Urowitz, David Wiljer
BACKGROUND: Cancer patients and their caregivers want information about their disease and are interested in finding health information online. Despite the abundance of cancer information online, it is often fragmented, its quality is highly variable, and it can be difficult to navigate without expert-level knowledge of the cancer system. The Patient & Family Library at the Princess Margaret Cancer Centre offers a broad collection of high-quality cancer health information and staff are available to help patrons refine their questions and explore information needs that they may not have considered...
May 24, 2017: JMIR Cancer
https://www.readbyqxmd.com/read/28504035/bleomycin-pulmonary-toxicity-does-not-adversely-affect-the-outcome-of-patients-with-hodgkin-lymphoma
#20
Haowei Linda Sun, Eshetu G Atenafu, Richard Tsang, Vishal Kukreti, Theodore K Marras, Michael Crump, John Kuruvilla
Bleomycin pulmonary toxicity (BPT) is a well-described complication of bleomycin-containing regimens. Previous data on risk factors and the impact of BPT on survival in Hodgkin lymphoma (HL) were conflicting. We reviewed 253 HL patients treated with adriamycin, bleomycin, vinblastine, dacarbazine (ABVD) at the Princess Margaret Hospital from 1999 to 2009 to examine the incidence and risk factors for BPT, and the effect of BPT on survival. BPT was defined by pulmonary symptoms, bilateral interstitial infiltrates on computed tomography, and the absence of infection...
May 15, 2017: Leukemia & Lymphoma
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