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https://www.readbyqxmd.com/read/28108038/the-effect-of-endotracheal-tubes-versus-laryngeal-mask-airways-on-perioperative-respiratory-adverse-events-in-infants-a-randomised-controlled-trial
#1
Thomas F E Drake-Brockman, Anoop Ramgolam, Guicheng Zhang, Graham L Hall, Britta S von Ungern-Sternberg
BACKGROUND: Perioperative respiratory adverse events (PRAE) are the most common critical incidents in paediatric anaesthesia and occur more often in infants. Use of laryngeal mask airways (LMAs) is associated with reduced PRAE compared with endotracheal tubes in older children (>1 year). We aimed to evaluate the effect of these devices on the incidence of PRAE in infants. METHODS: We did a randomised controlled trial at the Princess Margaret Hospital for Children in Perth (WA, Australia) by recruiting infants (aged 0-12 months) undergoing general (with or without regional or local) anaesthesia with anticipated fentanyl dose 1 μg/kg or lower for minor elective surgery...
January 17, 2017: Lancet
https://www.readbyqxmd.com/read/28065902/princess-privacy-protecting-rare-disease-international-network-collaboration-via-encryption-through-software-guard-extensions
#2
Feng Chen, Shuang Wang, Xiaoqian Jiang, Sijie Ding, Yao Lu, Jihoon Kim, S Cenk Sahinalp, Chisato Shimizu, Jane C Burns, Victoria J Wright, Eileen Png, Martin L Hibberd, David D Lloyd, Hai Yang, Amalio Telenti, Cinnamon S Bloss, Dov Fox, Kristin Lauter, Lucila Ohno-Machado
MOTIVATION: We introduce PRINCESS, a privacy-preserving international collaboration framework for analyzing rare disease genetic data that are distributed across different continents. PRINCESS leverages Software Guard Extensions (SGX) and hardware for trustworthy computation. Unlike a traditional international collaboration model, where individual-level patient DNA are physically centralized at a single site, PRINCESS performs a secure and distributed computation over encrypted data, fulfilling institutional policies and regulations for protected health information...
January 8, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28050143/socioeconomic-status-and-lifestyle-behaviours-in-cancer-survivors-smoking-and-physical-activity
#3
H Naik, X Qiu, M C Brown, L Eng, D Pringle, M Mahler, H Hon, K Tiessen, H Thai, V Ho, C Gonos, R Charow, V Pat, M Irwin, L Herzog, A Ho, W Xu, J M Jones, D Howell, G Liu
PURPOSE: Smoking cessation and increased physical activity (pa) have been linked to better outcomes in cancer survivors. We assessed whether socioeconomic factors influence changes in those behaviours after a cancer diagnosis. METHODS: As part of a cross-sectional study, a diverse group of cancer survivors at the Princess Margaret Cancer Centre (Toronto, ON), completed a questionnaire about past and current lifestyle behaviours and perceptions about the importance of those behaviours with respect to their health...
December 2016: Current Oncology
https://www.readbyqxmd.com/read/28047439/su-f-j-132-evaluation-of-ctv-to-ptv-expansion-for-whole-breast-radiotherapy
#4
B Burgdorf, G Freedman, B Teo
PURPOSE: The current standard CTV-to-PTV expansion for whole breast radiotherapy (WBRT) is 7mm, as recommended by RTOG-1005.This expansion is derived from the uncertainty due to patient positioning (±5mm) and respiratory motion (±5mm). We evaluated the expansion needed for respiratory motion uncertainty using 4DCT. After determining the appropriate expansion margins, RT plans were generated to evaluate the reduction in heart and lung dose. METHODS: 4DCT images were acquired during treatment simulation and retrospectively analyzed for 34 WBRT patients...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27965741/three-new-records-of-gammarid-amphipod-in-songkhla-lake-thailand
#5
Kotchakorn Rattanama, Manasawan Saengsakda Pattaratumrong, Prawit Towatana, Koraon Wongkamhaeng
Songkhla Lake is known as the most popular area for gammarid amphipod studies in the Gulf of Thailand. The first gammarid amphipod study was investigated in 1925 by Chilton. After that, there are various studies including diversity, ecology, and biology. In this study, gammarid amphipod in Songkhla Lake were collected from year 2010 to 2014. In this study, three newly recorded amphipods had been reported namely Hyale dollfusi Chevreux, 1911, Grandidierella megnae (Giles, 1888), and Hourstonius japonica (Hirayama, 1983) which had not been previously reported from the Thai waters...
November 2016: Tropical Life Sciences Research
https://www.readbyqxmd.com/read/27939842/atopic-characteristics-of-patients-with-vocal-cord-dysfunction
#6
Meagan W Shepherd, Casey Curtis, Shawn Long, Gary Phillips, Princess U Ogbogu
No abstract text is available yet for this article.
December 8, 2016: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/27932714/princess-royal-sees-how-creative-design-benefits-livestock-health-and-welfare
#7
(no author information available yet)
No abstract text is available yet for this article.
December 10, 2016: Veterinary Record
https://www.readbyqxmd.com/read/27917056/two-new-species-of-floresorchestia-crustacea-amphipoda-talitridae-in-thailand
#8
Koraon Wongkamhaeng, Pongrat Dumrongrojwattana, Manasawan Saengsakda Pattaratumrong
The beach-hopper and land-hopper genus Floresorchestia Bousfield, 1984 is most widespread in terrestrial and marine littoral habitats and has been recorded from the South African coasts through to tropical Indo-Pacific and Caribbean Sea. In Thailand, there is only Floresorchestia samroiyodensis Azman, Wongkamhaeng & Dumrongrojwattana, 2014 reported from the swamp of Prachuab Kiri Khan, southern Thailand. In this work, two new species of Floresorchestia from Phutsa Reservoir in Nakhon Ratchasima and the man-made swamp in Burapha University are described...
2016: ZooKeys
https://www.readbyqxmd.com/read/27913214/alk-rearranged-non-small-cell-lung-cancer-is-associated-with-a-high-rate-of-venous-thromboembolism
#9
Alona Zer, Mor Moskovitz, David M Hwang, Anat Hershko-Klement, Ludmila Fridel, Grzegorz J Korpanty, Elizabeth Dudnik, Nir Peled, Tzippy Shochat, Natasha B Leighl, Geoffrey Liu, Ronald Feld, Ronald Burkes, Mira Wollner, Ming-Sound Tsao, Frances A Shepherd
BACKGROUND: Patients with lung cancer are at increased risk for venous thromboembolism (VTE), particularly those receiving chemotherapy. It is estimated that 8% to 15% of patients with advanced non-small-cell lung cancer (NSCLC) experience a VTE in the course of their disease. The incidence in patients with specific molecular subtypes of NSCLC is unknown. We undertook this review to determine the incidence of VTE in patients with ALK (anaplastic lymphoma kinase)-rearranged NSCLC. PATIENTS AND METHODS: We identified all patients with ALK-rearranged NSCLC diagnosed and/or treated at the Princess Margaret Cancer Centre (PM CC) in Canada between July 2012 and January 2015...
October 26, 2016: Clinical Lung Cancer
https://www.readbyqxmd.com/read/27898699/facilitators-and-barriers-to-uptake-of-an-extended-seasonal-malaria-chemoprevention-programme-in-ghana-a-qualitative-study-of-caregivers-and-community-health-workers
#10
Gifty D Antwi, Laura A Bates, Rebecca King, Princess R Mahama, Harry Tagbor, Matt Cairns, James N Newell
BACKGROUND: Seasonal Malaria Chemoprevention (SMC) is currently recommended for children under five in areas where malaria transmission is highly seasonal. We explored children's caregivers' and community health workers' (CHWs) responses to an extended 5-month SMC programme. METHODS: Thirteen in-depth interviews and eight focus group discussions explored optimal and suboptimal 'uptake' of SMC to examine facilitators and barriers to caregivers' uptake. RESULTS: There did not appear to be major differences between caregivers of children with optimal and sub-optimal SMC uptake in terms of their knowledge of malaria, their perceptions of the effect of SMC on a child's health, nor their understanding of chemoprevention...
2016: PloS One
https://www.readbyqxmd.com/read/27881806/how-do-gloves-affect-cutaneous-sensibility-in-medical-practice-two-new-applied-tests
#11
Peter Mylon, Matt J Carré, Nicolas Martin, Roger Lewis
In order to quantify the effect of medical gloves on tactile performance, two new Simulated Medical Examination Tactile Tests (SMETT) have been developed to replicate the tactile and haptic ability required in medical examinations: the 'Bumps' test and the 'Princess and the Pea' (P&P) test. A pilot study was carried out using 30-40 subjects for each test in order to investigate the suitability of the tests for medical glove evaluation. Tests were performed with latex and nitrile examination gloves and without gloves...
January 2017: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/27856924/prevention-of-carboplatin-induced-hypersensitivity-reactions-in-women-with-ovarian-cancer
#12
Katarzyna J Jerzak, Shaidah Deghan Manshadi, Pamela Ng, Manjula Maganti, Jeanna M McCuaig, Marcus Bulter, Amit Oza, Helen J Mackay
BACKGROUND: Carboplatin-based chemotherapy offers high response rates and improved overall survival for women with epithelial ovarian cancer, but its use is limited by the occurrence of hypersensitivity reactions. To evaluate the efficacy of prophylactic diphenhydramine for hypersensitivity reaction prevention, we reviewed the incidence of hypersensitivity reactions and identified patients at high risk of hypersensitivity reactions. METHODS: Women receiving ≥6 cycles of carboplatin-based chemotherapy for epithelial ovarian cancer were identified from our institutional database at the Princess Margaret Cancer Centre...
November 17, 2016: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/27827316/brm-promoter-polymorphisms-risk-and-survival-of-advanced-non-small-cell-lung-cancer-patients-in-the-princess-margaret-cohort-and-ncic-ctg-br-24-trial
#13
Geoffrey Liu, Sinead Cuffe, Shermi Liang, Abul K Azad, Lu Cheng, Yonathan Brhane, Xin Qiu, David W Cescon, Jeff P Bruce, Zhuo Chen, Dangxiao Cheng, Devalben Patel, Brandon C Tse, Scott A Laurie, Glenwood D Goss, Natasha B Leighl, Rayjean J Hung, Penelope A Bradbury, Lesley Seymour, Frances A Shepherd, Ming-Sound Tsao, Bingshu E Chen, Wei Xu, David Reisman
PURPOSE: BRM, a key catalytic subunit of the SWI/SNF chromatin remodeling complex, is a putative tumor susceptibility gene that is silenced in 15% of non-small cell lung cancer (NSCLC). Two novel BRM promoter polymorphisms (BRM-741, BRM-1321) are associated with reversible epigenetic silencing of BRM protein expression. EXPERIMENTAL DESIGN: Advanced NSCLC patients from the Princess Margaret (PM) cohort study and from the CCTG BR.24 clinical trial were genotyped for BRM promoter polymorphisms...
November 8, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27819109/a-journey-in-science-not-lost-in-translation
#14
Tak Mak
Real innovations in medicine and science are historic and singular; the stories behind each occurrence are precious. At Molecular Medicine we have established the Anthony Cerami Award in Translational Medicine to document and preserve these histories. The monographs recount the seminal events as told in the voice of the original investigators who provided the crucial early insight. These essays capture the essence of discovery, chronicling the birth of ideas that created new fields of research; and launched trajectories that persisted and ultimately influenced how disease is prevented, diagnosed, and treated...
November 1, 2016: Molecular Medicine
https://www.readbyqxmd.com/read/27799624/protein-bound-toxins-has-the-cinderella-of-uraemic-toxins-turned-into-a-princess
#15
REVIEW
Sophie Liabeuf, Cédric Villain, Ziad A Massy
Chronic kidney disease (CKD) has emerged as a global public health problem. Although the incidence and prevalence of CKD vary from one country to another, the estimated worldwide prevalence is 8-16%. The complications associated with CKD include progression to end-stage renal disease (ESRD), mineral and bone disorders, anaemia, cognitive decline and elevated all-cause and cardiovascular (CV) mortality. As a result of progressive nephron loss, patients with late-stage CKD are permanently exposed to uraemic toxins...
December 1, 2016: Clinical Science (1979-)
https://www.readbyqxmd.com/read/27799447/substitution-rates-of-video-consultations-for-traditional-consultations-at-a-tertiary-public-hospital
#16
Liam J Caffery, Monica Taylor, Karen Lucas, Anthony C Smith
Using a case study approach, we conducted a retrospective review of 12 months of outpatient activity at the Princess Alexandra Hospital (PAH) in Brisbane, Australia. From our dataset we calculated two variables - the telehealth-eligible substitution rate and the overall telehealth substitution rate. Telehealth eligibility is specialty-specific and is based on clinical and geographical constraints. During the study period there were video consultations (N = 1088) and traditional consultations (N = 41,951)...
December 2016: Journal of Telemedicine and Telecare
https://www.readbyqxmd.com/read/27795698/implementation-and-evaluation-of-amyloidosis-subtyping-by-laser-capture-microdissection-and-tandem-mass-spectrometry
#17
Peter Mollee, Samuel Boros, Dorothy Loo, Jayde E Ruelcke, Vanessa A Lakis, Kim-Anh Lê Cao, Patricia Renaut, Michelle M Hill
BACKGROUND: Correct identification of the amyloidosis-causing protein is crucial for clinical management. Recently the Mayo Clinic reported laser-capture microdissection (LCM) with liquid chromatography-coupled tandem mass spectrometry (MS/MS) as a new diagnostic tool for amyloid diagnosis. Here, we report an independent implementation of this proteomic diagnostics method at the Princess Alexandra Hospital Amyloidosis Centre in Brisbane, Australia. RESULTS: From 2010 to 2014, 138 biopsies received from 35 different organ sites were analysed by LCM-MS/MS using Congo Red staining to visualise amyloid deposits...
2016: Clinical Proteomics
https://www.readbyqxmd.com/read/27787166/smartphone-app-could-help-to-test-for-atrial-fibrillation
#18
(no author information available yet)
A smartphone app used in conjunction with a heart monitor could test for atrial fibrillation, say researchers from the Princess Margaret Hospital in Hong Kong.
October 26, 2016: Nursing Standard
https://www.readbyqxmd.com/read/27783475/cancer-patients-willingness-to-routinely-complete-the-eq-5d-instrument-at-clinic-visits
#19
Hiten Naik, Xin Qiu, M Catherine Brown, Mary Mahler, Henrique Hon, Kyoko Tiessen, Henry Thai, Valerie Ho, Christina Gonos, Rebecca Charow, Vivien Pat, Margaret Irwin, Lindsay Herzog, Anthea Ho, Wei Xu, Doris Howell, Soo Jin Seung, Geoffrey Liu, Nicole Mittmann
BACKGROUND: Health utility (HU) scores play an essential role in pharmacoeconomic analyses. Routine clinical administration of the EuroQol-5 Dimensions (EQ-5D) can allow for HU and health related quality of life (HRQOL) assessments in the real-world setting. OBJECTIVES: The primary goals of this study were to evaluate whether patients were willing to complete the EQ-5D instrument on a routine basis and which clinical or demographic factors influence this willingness...
September 13, 2016: Journal of Population Therapeutics and Clinical Pharmacology
https://www.readbyqxmd.com/read/27782854/molecular-profiling-of-advanced-solid-tumors-and-patient-outcomes-with-genotype-matched-clinical-trials-the-princess-margaret-impact-compact-trial
#20
Tracy L Stockley, Amit M Oza, Hal K Berman, Natasha B Leighl, Jennifer J Knox, Frances A Shepherd, Eric X Chen, Monika K Krzyzanowska, Neesha Dhani, Anthony M Joshua, Ming-Sound Tsao, Stefano Serra, Blaise Clarke, Michael H Roehrl, Tong Zhang, Mahadeo A Sukhai, Nadia Califaretti, Mateya Trinkaus, Patricia Shaw, Theodorus van der Kwast, Lisa Wang, Carl Virtanen, Raymond H Kim, Albiruni R A Razak, Aaron R Hansen, Celeste Yu, Trevor J Pugh, Suzanne Kamel-Reid, Lillian L Siu, Philippe L Bedard
BACKGROUND: The clinical utility of molecular profiling of tumor tissue to guide treatment of patients with advanced solid tumors is unknown. Our objectives were to evaluate the frequency of genomic alterations, clinical "actionability" of somatic variants, enrollment in mutation-targeted or other clinical trials, and outcome of molecular profiling for advanced solid tumor patients at the Princess Margaret Cancer Centre (PM). METHODS: Patients with advanced solid tumors aged ≥18 years, good performance status, and archival tumor tissue available were prospectively consented...
October 25, 2016: Genome Medicine
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