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https://www.readbyqxmd.com/read/29132146/identification-of-unique-neoantigen-qualities-in-long-term-survivors-of-pancreatic-cancer
#1
Vinod P Balachandran, Marta Łuksza, Julia N Zhao, Vladimir Makarov, John Alec Moral, Romain Remark, Brian Herbst, Gokce Askan, Umesh Bhanot, Yasin Senbabaoglu, Daniel K Wells, Charles Ian Ormsby Cary, Olivera Grbovic-Huezo, Marc Attiyeh, Benjamin Medina, Jennifer Zhang, Jennifer Loo, Joseph Saglimbeni, Mohsen Abu-Akeel, Roberta Zappasodi, Nadeem Riaz, Martin Smoragiewicz, Z Larkin Kelley, Olca Basturk, Mithat Gönen, Arnold J Levine, Peter J Allen, Douglas T Fearon, Miriam Merad, Sacha Gnjatic, Christine A Iacobuzio-Donahue, Jedd D Wolchok, Ronald P DeMatteo, Timothy A Chan, Benjamin D Greenbaum, Taha Merghoub, Steven D Leach
Pancreatic ductal adenocarcinoma is a lethal cancer with fewer than 7% of patients surviving past 5 years. T-cell immunity has been linked to the exceptional outcome of the few long-term survivors, yet the relevant antigens remain unknown. Here we use genetic, immunohistochemical and transcriptional immunoprofiling, computational biophysics, and functional assays to identify T-cell antigens in long-term survivors of pancreatic cancer. Using whole-exome sequencing and in silico neoantigen prediction, we found that tumours with both the highest neoantigen number and the most abundant CD8(+) T-cell infiltrates, but neither alone, stratified patients with the longest survival...
November 8, 2017: Nature
https://www.readbyqxmd.com/read/29128266/molecular-profiling-of-patients-with-advanced-colorectal-cancer-princess-margaret-cancer-centre-experience
#2
Joanne W Chiu, Monika K Krzyzanowska, Stefano Serra, Jennifer J Knox, Neesha C Dhani, Helen Mackay, David Hedley, Malcolm Moore, Geoffrey Liu, Ronald L Burkes, Christine Brezden-Masley, Michael H Roehrl, Kenneth J Craddock, Ming-Sound Tsao, Tong Zhang, Celeste Yu, Suzanne Kamel-Reid, Lillian L Siu, Philippe L Bedard, Eric X Chen
BACKGROUND: Molecular aberrations in KRAS, NRAS, BRAF, and PIK3CA have been well-described in advanced colorectal cancer. The incidences of other mutations are less known. We report results of molecular profiling of advanced colorectal cancer in an academic cancer center. PATIENTS AND METHODS: Patients with advanced colorectal were enrolled in an institution-wide molecular profiling program. Profiling was performed on formalin-fixed paraffin embedded archival tissues using a customized MassArray panel (23 genes, 279 mutations) or the Illumina MiSeq TruSeq Cancer Panel (48 genes, 212 amplicons, ≥ 500× coverage) in a Clinical Laboratory Improvement Amendments-certified laboratory...
October 23, 2017: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/29097418/prevalence-and-treatment-outcomes-of-routine-chlamydia-trachomatis-neisseria-gonorrhoeae-and-trichomonas-vaginalis-testing-during-antenatal-care-gaborone-botswana
#3
Adriane Wynn, Doreen Ramogola-Masire, Ponatshego Gaolebale, Neo Moshashane, Ontiretse Sickboy, Sofia Duque, Elizabeth Williams, Klara Doherty, Jeffrey D Klausner, Chelsea Morroni
OBJECTIVES: Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG) and Trichomonas vaginalis (TV) are curable, mostly asymptomatic, STIs that cause adverse maternal and perinatal outcomes. Most countries do not test for those infections during antenatal care. We implemented a CT, NG and TV testing and treatment programme in an antenatal clinic in Gaborone, Botswana. METHODS: We conducted a prospective study in the antenatal clinic at Princess Marina Hospital in Gaborone, Botswana...
November 2, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29095487/the-prognostic-value-of-perioperative-pre-systemic-therapy-ca125-levels-in-patients-with-high-grade-serous-ovarian-cancer
#4
Taymaa May, Jocelyn M Stewart, Marcus Q Bernardini, Sarah E Ferguson, Stephane Laframboise, Haiyan Jiang, Barry Rosen
OBJECTIVE: To investigate the ability of preoperative CA125 and post-surgical CA125 changes to predict outcomes among patients with high-grade serous ovarian cancer (HGSC). METHODS: The present retrospective cohort study included patients with HGSC who underwent surgery between January 1, 2003, and December 31, 2011 at Princess Margaret Cancer Center, Toronto, ON, Canada. CA125 was measured at diagnosis and following surgery, and the CA125 ratio was calculated (preoperative CA125/postoperative CA125)...
November 2, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29094370/post-ebola-situational-assessment-of-opportunities-for-capacity-building-at-the-national-obstetrics-and-gynecology-referral-hospital-in-sierra-leone
#5
Rachel Chan Seay, Alimamy P Koroma, Jenell Coleman, John Sampson, Lucy Koroma, Emmanuel A Ugwa, Jean Anderson
OBJECTIVE: To describe a site assessment of the Princess Christian Maternity Hospital (PCMH; Freetown, Sierra Leone), the national referral center for reproductive, maternal, newborn, child and adolescent health (RMNCAH) services and logical site for focused efforts to train and expand the RMNCAH workforce in Sierra Leone. METHODS: In April 2016, a mixed-methods assessment approach was used involving facility observation and staff interviews using the WHO's Service Availability and Readiness Assessment (SARA) tool...
November 2, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29067871/antiphospholipid-syndrome-and-iga-anti-beta2-glycoprotein-i-antibodies-when-cinderella-becomes-a-princess
#6
D Pérez, A Tincani, M Serrano, Y Shoenfeld, A Serrano
IgA anti-beta2-glycoprotein I (IgA-aB2GPI) antibodies are currently not included as a laboratory criterion of antiphospholipid syndrome (APS). In the 13th International Congress on Antiphospholipid Antibodies, Galveston, TX, (USA) in 2010, these antibodies were accepted as an APS laboratory criterion in patients who had clinical manifestations of APS but were negative for "consensus" antiphospholipid antibodies (aPL) (IgG and IgM isotypes). Consequently, individuals with thrombotic events who are negative for consensus aPL may be undiagnosed for APS...
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/29057116/prevalence-of-intestinal-helminths-infestation-in-children-attending-princess-marie-louise-children-s-hospital-in-accra-ghana
#7
Robert Mirisho, Margaret L Neizer, Bismark Sarfo
The deworming exercise program does not cover all children who are not in school. This study determined the prevalence and species type of helminth infestation and associated factors among children attending Princess Marie Louise Children's Hospital in Accra, Ghana. Children (225) below the age of 10 who have not taken antihelminthic drugs prior to the study period were recruited between May and June 2015. Children or guardians were interviewed using structured questionnaires and fresh stools were collected and processed for helminths species identification using microscopy...
2017: Journal of Parasitology Research
https://www.readbyqxmd.com/read/29045009/trends-in-non-lactation-breast-abscesses-in-a-tertiary-hospital-setting
#8
Apoorva Saboo, Ian Bennett
BACKGROUND: The aim of this paper was to retrospectively review non-lactation breast abscesses treated in Princess Alexandra Hospital over a 10-year period and to illustrate the trends in size, risk factors, microbiological profile and management. METHODS: A computerized search of the medical records was undertaken to identify all adult patients with a diagnosis of breast abscesses during June 2005-June 2015. Patients concurrently breastfeeding were excluded. A retrospectively review of the clinical records was performed...
October 18, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28978650/validity-of-triage-systems-for-paediatric-emergency-care-a-systematic-review
#9
REVIEW
Maria Clara de Magalhães-Barbosa, Jaqueline Rodrigues Robaina, Arnaldo Prata-Barbosa, Claudia de Souza Lopes
AIM: To present a systematic review on the validity of triage systems for paediatric emergency care. METHODS: Search in MEDLINE, Cochrane Library, Latin American and Caribbean Health Sciences Literature (LILACS), Scientific Electronic Library Online (SciELO), Nursing Database Index (BDENF) and Spanish Health Sciences Bibliographic Index (IBECS) for articles in English, French, Portuguese or Spanish with no time limit. Validity studies of five-level triage systems for patients 0-18 years old were included...
November 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/28967168/serum-procalcitonin-levels-predict-acute-kidney-injury-in-critically-ill-patients
#10
Rajeev Jeeha, David Lee Skinner, Kim De Vasconcellos, Nombulelo Princess Magula
AIM: To determine whether admission procalcitonin (PCT) was associated with the subsequent development of AKI in a general population of critically ill patients. METHODS: The study was a retrospective observational study conducted in a multidisciplinary intensive care unit (ICU) over a period of 1 year. Adult patients who had a PCT performed on admission and who did not have CKD or AKI on admission, were evaluated for the development of AKI within the first week of ICU admission, according to the KDIGO criteria...
October 2, 2017: Nephrology
https://www.readbyqxmd.com/read/28961081/princesses-princes-and-superheroes-children-s-gender-cognitions-and-fictional-characters
#11
Lisa M Dinella, Juliana M Claps, Gary W Lewandowski
The goal of the present study was to identify whether children recognize the gender stereotypes prevalent within the increasingly popular princess, prince, and superhero characters. Interviews with 126 children from the northeast region of the Unites States (3-11 years old) indicated that children recognized the gender-typed personality traits of princesses, princes, and superheroes, with older children holding more gender-typed cognitions about the characters. Children's own-schemas (i.e., beliefs that apply to themselves) and superordinate schemas (i...
September 2017: Journal of Genetic Psychology
https://www.readbyqxmd.com/read/28959066/breast-cancer-screening-in-a-resource-poor-country-ultrasound-versus-mammography
#12
Olubukola At Omidiji, Princess C Campbell, Nicholas K Irurhe, Omolola M Atalabi, Oluyemisi O Toyobo
BACKGROUND: Breast cancer is the commonest female cancer in Nigeria. Despite its increased awareness, affordability of available screening tools is a bane. Mammography, the goal standard for screening is costly and not widely available in terms of infrastructure, technical/personnel capabilities. Ultrasound is accessible and affordable. OBJECTIVES: This study compared the use of ultrasound and mammography as breast cancer screening tools in women in South West Nigeria by characterizing and comparing the prevalent breast parenchyma, breast cancer features and the independent sensitivity of ultrasound and mammography...
March 2017: Ghana Medical Journal
https://www.readbyqxmd.com/read/28958210/clavicle-fracture-management-a-comparison-of-a-tertiary-hospital-and-rural-telehealth-sites
#13
Megan McKerrow, John North
The clavicle is one of the most commonly fractured bones in the adult population. Management has traditionally been conservative, however more recent research has yielded higher non-union rates associated with non-operative management. This study aims to analyse the proportion of operative and non-operative treatment methods for clavicle fracture in a tertiary hospital facility and rural health sites accessed via telehealth, comparing patient outcome between these two methods of fracture management. Following ethical approval, a retrospective review was conducted of patients presenting with clavicle fractures to the Princess Alexandra Hospital Fracture Clinics and to Orthopaedic Fracture Clinics run via teleconference with rural health sites...
January 1, 2017: Journal of Telemedicine and Telecare
https://www.readbyqxmd.com/read/28953052/demonstrating-improved-surgical-communication-and-handover-generates-earlier-discharges-discharged
#14
Jonathon Dean, Georgina Phillips, Warren Turner, Jonathan Refson
BACKGROUND: Weekend surgical handover at the Princess Alexandra Hospital NHS Trust in Harlow, Essex, did not fully comply with Royal College of Surgeons England guidelines. Out-of-hours care is under increased scrutiny, and we implemented a quality improvement intervention of a mandatory, standardized weekend handover form to streamline weekend care. This was shown to increase discharges and decrease lengths of stay for patients whose hospital stay included a weekend. METHODS: Data were collected for 15-week preimplementation and postimplementation...
September 25, 2017: Journal of Patient Safety
https://www.readbyqxmd.com/read/28945208/digestion-of-human-milk-oligosaccharides-by-bifidobacterium-breve-in-the-premature-infant
#15
Mark A Underwood, Jasmine C C Davis, Karen M Kalanetra, Sanjay Gehlot, Sanjay Patole, Daniel J Tancredi, David A Mills, Carlito B Lebrilla, Karen Simmer
OBJECTIVE: The aim of this study was to measure consumption and absorption of human milk oligosaccharides (HMOs) in a cohort of premature infants treated with probiotic Bifidobacterium breve. METHODS: Twenty-nine premature infants (median gestational age 28 weeks, range 23-32 weeks) cared for in the neonatal intensive care unit of the King Edward and Princess Margaret Hospital in Perth, Australia, were treated with B breve at a dose of 1.66 billion organisms per day...
October 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28932397/undiagnosed-and-diagnosed-diabetes-mellitus-among-hospitalised-acute-heart-failure-patients-in-botswana
#16
Julius Chacha Mwita, Mgaywa Gilbert Mjungu Damas Magafu, Bernard Omech, Billy Tsima, Matthew J Dewhurst, Monkgogi Goepamang, Yohana Mashalla
OBJECTIVE: The objective of this study was to determine the burden of diagnosed and undiagnosed type 2 diabetes mellitus among patients hospitalised with acute heart failure in Botswana. METHODS: The study enrolled 193 consecutive patients admitted with acute heart failure to the medical wards at Princess Marina Hospital in Gaborone. Patients were classified as previously known diabetics, undiagnosed diabetics (glycated haemoglobin ≥ 6.5%) or as non-diabetics (glycated haemoglobin < 6...
2017: SAGE Open Medicine
https://www.readbyqxmd.com/read/28921401/experience-with-curative-radiotherapy-for-cervix-cancer-in-the-bahamas-for-2006-2016
#17
Glenn Jones, Osama Kellini, Nevein Girgis, Darron Halliday, Raleigh Butler, Thomas McGowan, Conville Brown
BACKGROUND: Cervix cancer is a significant health problem. As access to quality care in Small Island Developing States improves, and cancer centers become established, providers of care can summarize local experience to benchmark system quality and look for ways to further improve value. METHODS: This is a retrospective study of all cases of cervix cancer managed 2006-2016 at The Cancer Centre Bahamas, in conjunction with Princess Margaret Hospital, Nassau, affiliated with The University of West Indies...
November 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28874902/lymph-node-retrieval-rates-in-melanoma-a-quality-assessment-parameter
#18
D Berger-Richardson, E Cordeiro, M Ernjakovic, A M Easson
INTRODUCTION: Regional lymph node dissection (rlnd) for melanoma with nodal metastasis is a specialized procedure that is associated with improved disease-specific survival in selected patients. Furthermore, there is evidence that a higher lymph node retrieval rate (lnrr) is associated with improved local control. Currently, no consensus has been reached on the definition of an adequate lnrr. A minimum lnrr has been proposed as a quality assessment parameter that has to be validated. METHODS: We conducted a retrospective cohort analysis at the Princess Margaret Cancer Centre (University Health Network, Toronto, ON)...
August 2017: Current Oncology
https://www.readbyqxmd.com/read/28870202/an-assessment-of-healthcare-professionals-knowledge-about-and-attitude-towards-influenza-vaccination-in-freetown-sierra-leone-a-cross-sectional-study
#19
Peter Bai James, Inayat Ur Rehman, Abudulai Jawo Bah, Michael Lahai, Christine Princess Cole, Tahir Mehmood Khan
BACKGROUND: Vaccinating healthcare professionals against influenza is considered an effective infection control measure. However, there is a low uptake of influenza vaccine among healthcare professionals around the globe. Currently, it is unknown whether healthcare professionals in Sierra Leone are aware of, and have been vaccinated against influenza. Also, there is a paucity of research evidence on their level of knowledge and attitude toward influenza vaccination. This study assessed healthcare professionals' current influenza vaccine uptake rate, reasons for not getting vaccinated as well as their awareness, knowledge of, and attitude towards influenza vaccination in Freetown Sierra Leone...
September 5, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28838393/prognostic-and-predictive-effects-of-tp53-co-mutation-in-patients-with-egfr-mutated-non-small-cell-lung-cancer-nsclc
#20
Catherine Labbé, Michael Cabanero, Grzegorz J Korpanty, Pascale Tomasini, Mark K Doherty, Céline Mascaux, Kevin Jao, Bethany Pitcher, Rick Wang, Melania Pintilie, Natasha B Leighl, Ronald Feld, Geoffrey Liu, Penelope Ann Bradbury, Suzanne Kamel-Reid, Ming-Sound Tsao, Frances A Shepherd
INTRODUCTION: TP53 mutations are common in non-small cell lung cancer (NSCLC) and have been reported as prognostic of poor outcome. The impact of TP53 co-mutations in epidermal growth factor receptor (EGFR)-mutated NSCLC is unclear. MATERIALS AND METHODS: Tissue from 105 patients with EGFR-mutated NSCLC at Princess Margaret Cancer Centre was analyzed by next-generation or Sanger sequencing to determine TP53 mutational status. Associations between TP53 status and baseline patient and tumor characteristics, treatments and outcomes (relapse-free survival [RFS] after surgical resection, overall survival [OS], overall response rate [ORR] and progression-free survival [PFS] on EGFR tyrosine kinase inhibitors [TKIs]), were investigated...
September 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
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