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https://www.readbyqxmd.com/read/28900748/serum-interleukin-6-levels-are-associated-with-depressive-state-of-the-patients-with-knee-osteoarthritis-irrespective-of-disease-severity
#1
Yukio Shimura, Hisashi Kurosawa, Masaru Tsuchiya, Mamiko Sawa, Haruka Kaneko, Lizu Liu, Yuji Makino, Hidetoshi Nojiri, Yoshiyuki Iwase, Kazuo Kaneko, Muneaki Ishijima
This cross-sectional study investigated the prevalence of depressive state and association between depressive state and serum interleukin (IL)-6 levels in knee osteoarthritis (OA) patients. A total of 115 painful knee OA patients were enrolled and divided into two groups according to the radiographic OA severity. Pain was evaluated using a visual analog scale (VAS). Depressive state was assessed by the self-rating depression scale (SDS). Serum IL-6 levels were also measured. Pearson's correlation coefficient was used to assess the correlation between the variants tested, and logistic regression analysis was used to identify factors associated with the depressive state...
September 12, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28893764/prevalence-of-cerebral-microbleeds-in-patients-with-continuous-flow-left-ventricular-assist-devices
#2
Daisuke Yoshioka, Shuhei Okazaki, Koichi Toda, Sho Murase, Shunsuke Saito, Keitaro Domae, Shigeru Miyagawa, Yasushi Yoshikawa, Takashi Daimon, Manabu Sakaguchi, Yoshiki Sawa
BACKGROUND: The prevalence of cerebral microbleeds (CMBs) in gradient echo T2*-weighted brain MRI has a positive correlation with hemorrhagic stroke incidence. However, the prevalence of CMBs in patients with left ventricular assist devices (LVADs) has not been evaluated. We evaluated the prevalence of CMBs and the relationship with hemorrhagic stroke incidence in patients with LVADs. METHOD AND RESULTS: We analyzed results from brain MRI in prospective examinations of 35 consecutive patients who had undergone LVAD explantation for heart transplantation or recovery since 2011...
September 11, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28892069/reduction-of-plasma-glutathione-in-psychosis-associated-with-schizophrenia-and-bipolar-disorder-in-translational-psychiatry
#3
L G Nucifora, T Tanaka, L N Hayes, M Kim, B J Lee, T Matsuda, F C Nucifora, T Sedlak, R Mojtabai, W Eaton, A Sawa
The establishment of mechanism-driven peripheral markers is important for translational psychiatry. Many groups, including ours, have addressed molecular alterations in peripheral tissues in association with symptomatic changes in major illnesses. Oxidative stress is implicated in the pathophysiology of schizophrenia (SZ) and bipolar disorder (BP) through studies of patient peripheral tissues and animal models. Although the relationship between peripheral changes and brain pathology remain elusive, oxidative stress may bridge such translational efforts...
August 22, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28890406/comparison-of-conditioning-with-fludarabine-busulfan-and-fludarabine-melphalan-in-allogeneic-transplant-recipients-50-years-or-older
#4
Koji Kawamura, Shinichi Kako, Shuichi Mizuta, Ken Ishiyama, Jun Aoki, Shingo Yano, Takahiro Fukuda, Naoyuki Uchida, Yukiyasu Ozawa, Tetsuya Eto, Koji Iwato, Heiwa Kanamori, Kaoru Kahata, Tadakazu Kondo, Masashi Sawa, Tatsuo Ichinohe, Yoshiko Atsuta, Yoshinobu Kanda
The optimal conditioning regimen for elderly patients in allogeneic hematopoietic stem cell transplantation (allo-HCT) remains unclear. We retrospectively analyzed 1607 patients aged 50 years or older with acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), or myelodysplastic syndrome (MDS) who underwent allo-HCT using fludarabine/busulfan (FB) or fludarabine/melphalan (FM) between 2007 and 2014. We compared the clinical outcomes among FB2 (busulfan at 6.4 mg/kg iv, n=463), FB4 (busulfan at 12...
September 7, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28890347/high-resolution-structure-discloses-the-potential-for-allosteric-regulation-of-mitogen-activated-protein-kinase-kinase-7
#5
Takayoshi Kinoshita, Takuma Hashimoto, Yuri Sogabe, Harumi Fukada, Takashi Matsumoto, Masaaki Sawa
Mitogen-activated protein kinase kinase 7 (MAP2K7) regulates stress and inflammatory responses, and is an attractive drug discovery target for several diseases including arthritis and cardiac hypertrophy. Intracellular proteins such as MAP2K7 are prone to aggregation due to cysteine-driven oxidation in in vitro experiments. MAP2K7 instability due to the four free cysteine residues on the molecular surface abrogated the crystal growth and led to a low-resolution structure with large residual errors. To acquire a higher resolution structure for promoting rational drug discovery, we explored stable mutants of MAP2K7 by replacing the surface cysteine residues, Cys147, Cys218, Cys276 and Cys296...
September 7, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28887708/long-term-clinical-results-of-acute-myocardial-infarction-at-the-left-main-trunk-requiring-percutaneous-cardiopulmonary-support
#6
Takashi Yamauchi, Takafumi Masai, Kenji Fujii, Yoshiki Sawa, Shinya Shirai, Mitsunori Kamigaki, Naofumi Itou
The clinical results of patients with acute myocardial infarction (AMI) at the left main trunk (LMT) remain unclear, especially in cases requiring percutaneous cardiopulmonary support (PCPS). Twenty seven cases of AMI at the LMT requiring emergent PCPS were retrospectively investigated. These 27 patients were aged 44-83 years (65.6 ± 8.6 years) and 20 (81.5%) were men. Peak creatine kinase (CK) leakage ranged from 538 to 34,010 IU/l (13,553 ± 7656 IU/l). Eight (29.6%) patients were discharged without mechanical support...
September 8, 2017: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/28886358/open-sesame-open-chromatin-regions-shed-light-onto-non-coding-risk-variants
#7
Kun Yang, Akira Sawa
Human genetics and stem cell biology have advanced neurobiology for neurodevelopmental psychiatric disorders. In this issue of Cell Stem Cell, Forrest et al. (2017) demonstrate that studying the landscape of open chromatin regions in stem cell-derived neurons helps functional interpretation of non-coding genetic variants associated with these diseases.
September 7, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/28882590/targeted-deletion-of-rankl-in-m-cell-inducer-cells-by-the-col6a1-cre-driver
#8
Kazuki Nagashima, Shinichiro Sawa, Takeshi Nitta, Alejandro Prados, Vasiliki Koliaraki, George Kollias, Tomoki Nakashima, Hiroshi Takayanagi
The gut-associated lymphoid tissues (GALTs), including Peyer's patches (PPs), cryptopatches (CPs) and isolated lymphoid follicles (ILFs), establish a host-microbe symbiosis by the promotion of immune reactions against gut microbes. Microfold cell inducer (MCi) cells in GALTs are the recently identified mesenchymal cells that express the cytokine RANKL and initiate bacteria-specific immunoglobulin A (IgA) production via induction of microfold (M) cell differentiation. In the previous study, the Twist2-Cre driver was utilized for gene deletion in mesenchymal cells including MCi cells...
September 5, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28874850/structures-and-biological-activities-of-novel-4-acetylated-analogs-of-chrysomycins-a-and-b
#9
Shun-Ichi Wada, Ryuichi Sawa, Fumiki Iwanami, Miho Nagayoshi, Yumiko Kubota, Kiyoko Iijima, Chigusa Hayashi, Yuko Shibuya, Masaki Hatano, Masayuki Igarashi, Manabu Kawada
Two new 4'-acetylated analogs of chrysomycin were discovered during the screening for antitumor agents from the metabolites of actinomycetes. Their structures and physicochemical properties were determined by standard spectrometric analyses. Their cytotoxicities and antimicrobial activities were evaluated against a panel of cancer cell lines and microbes. While acetylation reinforced the cytotoxicity of chrysomycin B, it weakened the activity of chrysomycin A. Chrysomycin A and its acetylated analog showed high cytotoxicity toward most of the cancer cells with IC50s less than 10 ng ml(-1)...
September 6, 2017: Journal of Antibiotics
https://www.readbyqxmd.com/read/28874847/a-guanine-derivative-as-a-new-mek-inhibitor-produced-by-streptomyces-sp-mk63-43f2
#10
Masatomi Iijima, Yuji Kubota, Ryuichi Sawa, Yumiko Kubota, Masaki Hatano, Masayuki Igarashi, Manabu Kawada, Isao Momose, Mutsuhiro Takekawa, Masakatsu Shibasaki
Mitogen-activated protein kinase (MAPK) pathways that direct cellular responses are involved in various biological processes; the RAS-RAF-MEK-ERK pathway is one of the most important MAPK pathways. It is frequently activated in human malignant tumors such as melanomas, thyroid tumors and colorectal carcinomas. Therefore, targeting this pathway has been considered an attractive strategy for new anticancer drugs. In particular, MEK is a promising target because it is a kinase that directly phosphorylates ERK...
September 6, 2017: Journal of Antibiotics
https://www.readbyqxmd.com/read/28873973/effect-of-renal-transcatheter-arterial-embolization-on-quality-of-life-in-patients-with-autosomal-dominant-polycystic-kidney-disease
#11
Tatsuya Suwabe, Yoshifumi Ubara, Akinari Sekine, Toshiharu Ueno, Masayuki Yamanouchi, Noriko Hayami, Junichi Hoshino, Masahiro Kawada, Rikako Hiramatsu, Eiko Hasegawa, Naoki Sawa, Kenmei Takaichi
Background: Currently, there are few strategies for improving the quality of life (QOL) in patients with autosomal dominant polycystic kidney disease (ADPKD) and massive kidneys. Renal transcatheter arterial embolization (TAE) reduces kidney volume, but its impact on QOL in ADPKD patients on hemodialysis is unknown. This study investigated the influence of renal TAE on QOL in ADPKD patients with massive kidneys receiving hemodialysis. Methods: This prospective observational study enrolled 188 ADPKD patients on hemodialysis (92 men and 96 women; mean age 56...
July 1, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28868300/aa-amyloidosis-and-atypical-familial-mediterranean-fever-with-exon-2-and-3-mutations
#12
Junko Yabuuchi, Noriko Hayami, Junichi Hoshino, Keiichi Sumida, Tatsuya Suwabe, Toshiharu Ueno, Akinari Sekine, Masahiro Kawada, Masayuki Yamanouchi, Rikako Hiramatsu, Eiko Hasegawa, Naoki Sawa, Kenmei Takaichi, Takeshi Fujii, Kenichi Ohashi, Kiyoshi Migita, Takao Masaki, Yoshifumi Ubara
A 54-year-old Japanese man presented with recurrent abdominal pain, fever lasting >5 days, and renal failure. AA amyloidosis was proven by renal and gastric biopsy. Symptoms subsided with the administration of colchicine, but a subsequent recurrence of symptoms did not respond to colchicine. Mediterranean fever gene (MEFV) analysis showed that he was heterozygous for mutations in exon 2 (E148Q/R202Q) and exon 3 (P369S/R408Q), although he had none of the exon 10 mutations known to be closely related to AA amyloidosis...
May 2017: Case Reports in Nephrology and Dialysis
https://www.readbyqxmd.com/read/28867073/metal-stents-versus-plastic-stents-for-the-management-of-pancreatic-walled-off-necrosis-a-systematic-review-and-meta-analysis
#13
REVIEW
Fateh Bazerbachi, Tarek Sawas, Eric J Vargas, Larry J Prokop, Suresh T Chari, Ferga C Gleeson, Michael J Levy, John Martin, Bret T Petersen, Randall K Pearson, Mark D Topazian, Santhi S Vege, Barham K Abu Dayyeh
BACKGROUND AND AIMS: Endoscopic transluminal drainage of symptomatic walled-off necrosis (WON) is a good management option, although the optimal choice of drainage site stent is unclear. We performed a systematic review and meta-analysis to compare metal stents (MSs) and plastic stents (PSs) in terms of WON resolution, likelihood of resolution after one procedure, and adverse events. METHODS: An expert librarian queried several databases to identify studies that assessed WON management, and selection was according to a priori criteria...
August 31, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28861008/case-of-secondary-tics-associated-with-olanzapine-in-an-adult
#14
Eric W Mills, Lindsay S Shaffer, Fernando S Goes, Akira Sawa, Frederick C Nucifora
Atypical antipsychotic medications, such as risperidone, aripiprazole, and olanzapine, have utility in treating motor tics, particularly in Tourette syndrome. In rare cases, atypical antipsychotic medications have been associated with adult-onset motor tics. Such adverse drug reactions have been documented in response to quetiapine, aripiprazole, and amisulpride. Here, we report, to our knowledge, the first case of adult-onset motor tics related to olanzapine administration.
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28860392/factors-affecting-the-potential-for-posterior-bony-impingement-after-total-hip-arthroplasty
#15
T Shoji, T Yamasaki, S Izumi, H Murakami, K Mifuji, M Sawa, Y Yasunaga, N Adachi, M Ochi
AIMS: Our aim was to evaluate the radiographic characteristics of patients undergoing total hip arthroplasty (THA) for the potential of posterior bony impingement using CT simulations. PATIENTS AND METHODS: Virtual CT data from 112 patients who underwent THA were analysed. There were 40 men and 72 women. Their mean age was 59.1 years (41 to 76). Associations between radiographic characteristics and posterior bony impingement and the range of external rotation of the hip were evaluated...
September 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/28858727/association-between-joint-stiffness-and-health-related-quality-of-life-in-community-dwelling-older-adults
#16
Shunsuke Murata, Takehiko Doi, Ryuichi Sawa, Takashi Saito, Ryo Nakamura, Tsunenori Isa, Aoi Ebina, Yuki Kondo, Yamato Tsuboi, Shogo Misu, Rei Ono
OBJECTIVE: This study aimed to examine the association between joint stiffness and health-related quality of life (HRQOL) in community-dwelling older adults. METHODS: Participants in this cross-sectional study were 530 Japanese community-dwelling older adults (mean age, 73.9 years; women, 64.3%). Joint stiffness was assessed at the neck, low back, shoulder, elbow, hand or wrist, hip, knee, and ankle or feet; the duration of joint stiffness was also evaluated. We assessed HRQOL using the Short Form-12 (SF-12) and EuroQOL-5 Dimension (EQ-5D) questionnaires...
August 1, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28855436/effects-of-sorafenib-and-an-adenylyl-cyclase-activator-on-in-vitro-growth-of-well-differentiated-thyroid-cancer-cells
#17
Aya Sawa, Tomohiro Chiba, Jun Ishii, Hiroyuki Yamamoto, Hisato Hara, Hiroshi Kamma
Well-differentiated thyroid carcinomas have driver mutations involving growth factor receptor-tyrosine kinases (RTKs) or their intracellular signaling pathway, that is, the mitogen-activated protein kinase (MAPK) pathway. Sorafenib is a multikinase inhibitor of RTKs and the MAPK pathway and has recently been used for the treatment of unresectable well-differentiated thyroid carcinoma. In normal thyroid follicular cells, stimulation of the thyroid-stimulating hormone (TSH) receptor activates the cyclic adenosine monophosphate (cAMP) pathway and promotes cell growth as well as hormonal secretion...
August 31, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28838518/midventricular-obstruction-caused-by-abnormal-intra-left-ventricular-septum-and-papillary-muscles
#18
Takaaki Samura, Koichi Toda, Shunsuke Saito, Shigeru Miyagawa, Yasushi Yoshikawa, Satsuki Fukushima, Daisuke Yoshioka, Keitaro Domae, Yoshiki Sawa
Abnormal papillary muscle is a rare cause of midventricular obstruction. In this case report, hypertrophied abnormal papillary muscles and abnormal tissue growth from the septal wall formed an intra-left ventricular septum with a small hole and resulted in severe midventricular obstruction. Radical resection of both papillary muscles and the intra-left ventricular septum was performed along with mitral valve replacement to relieve the obstruction.
September 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28837763/exposure-to-electrophiles-impairs-reactive-persulfide-dependent-redox-signaling-in-neuronal-cells
#19
Hideshi Ihara, Shingo Kasamatsu, Atsushi Kitamura, Akira Nishimura, Hiroyasu Tsutsuki, Tomoaki Ida, Kento Ishizaki, Takashi Toyama, Eiko Yoshida, Hisyam Abdul Hamid, Minkyung Jung, Tetsuro Matsunaga, Shigemoto Fujii, Tomohiro Sawa, Motohiro Nishida, Yoshito Kumagai, Takaaki Akaike
Electrophiles such as methylmercury (MeHg) affect cellular functions by covalent modification with endogenous thiols. Reactive persulfide species were recently reported to mediate antioxidant responses and redox signaling because of their strong nucleophilicity. In this study, we used MeHg as an environmental electrophile and found that exposure of cells to the exogenous electrophile elevated intracellular concentrations of the endogenous electrophilic molecule 8-nitroguanosine 3',5'-cyclic monophosphate (8-nitro-cGMP), accompanied by depletion of reactive persulfide species and 8-SH-cGMP which is a metabolite of 8-nitro-cGMP...
September 7, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/28837679/influence-of-coronary-architecture-on-the-variability-in-myocardial-infarction-induced-by-coronary-ligation-in-rats
#20
Satoshi Kainuma, Shigeru Miyagawa, Satsuki Fukushima, Hirotsugu Tsuchimochi, Takashi Sonobe, Yutaka Fujii, James T Pearson, Atsuhiro Saito, Akima Harada, Koichi Toda, Mikiyasu Shirai, Yoshiki Sawa
It has been shown that the size of myocardial infarction in rats created by coronary ligation technique is not uniform, varying from 4% to 65%. We hypothesized that infarct size variability induced by coronary artery ligation might be caused by coronary artery branching pattern. Coronary artery angiography was performed in 50 normal Lewis rats and in chronic myocardial infarction models in which coronary artery was ligated immediately below the left atrial appendage or 2mm distal to the left atrial appendage (n = 25 for each), followed by histological analysis...
2017: PloS One
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