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https://www.readbyqxmd.com/read/29348204/tumor-suppressor-apc-is-an-attenuator-of-spindle-pulling-forces-during-c-elegans-asymmetric-cell-division
#1
Kenji Sugioka, Lars-Eric Fielmich, Kota Mizumoto, Bruce Bowerman, Sander van den Heuvel, Akatsuki Kimura, Hitoshi Sawa
The adenomatous polyposis coli (APC) tumor suppressor has dual functions in Wnt/β-catenin signaling and accurate chromosome segregation and is frequently mutated in colorectal cancers. Although APC contributes to proper cell division, the underlying mechanisms remain poorly understood. Here we show that Caenorhabditis elegans APR-1/APC is an attenuator of the pulling forces acting on the mitotic spindle. During asymmetric cell division of the C. elegans zygote, a LIN-5/NuMA protein complex localizes dynein to the cell cortex to generate pulling forces on astral microtubules that position the mitotic spindle...
January 18, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29344797/annular-dynamics-of-memo3d-annuloplasty-ring-evaluated-by-3d-transesophageal-echocardiography
#2
Hiroyuki Nishi, Koichi Toda, Shigeru Miyagawa, Yasushi Yoshikawa, Satsuki Fukushima, Daisuke Yoshioka, Yoshiki Sawa
BACKGROUND: We assessed the mitral annular motion after mitral valve repair with the Sorin Memo 3D® (Sorin Group Italia S.r.L., Saluggia, Italy), which is a unique complete semirigid annuloplasty ring intended to restore the systolic profile of the mitral annulus while adapting to the physiologic dynamism of the annulus, using transesophageal real-time three-dimensional echocardiography. METHODS: 17 patients (12 male; mean age 60.4 ± 14.9 years) who underwent mitral annuloplasty using the Memo 3D ring were investigated...
January 17, 2018: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29340155/preservation-of-renal-function-by-intensive-glycemic-control
#3
Naoya Toriu, Masayuki Yamanouchi, Rikako Hiramatsu, Noriko Hayami, Junichi Hoshino, Akinari Sekine, Masahiro Kawada, Eiko Hasegawa, Tatsuya Suwabe, Keiichi Sumida, Toshiharu Ueno, Naoki Sawa, Kenichi Ohashi, Takeshi Fujii, Kenmei Takaichi, Motoko Yanagita, Tetsuro Kobayasi, Yoshifumi Ubara
We report the case of a 67-year-old Japanese woman with type 1 diabetes mellitus. At 47 years of age, her hemoglobin A1c (HbA1c) was 10.0%, and she had overt nephropathy. The first renal biopsy yielded a diagnosis of diabetic nephropathy. Intensive glycemic control was initiated and her HbA1c improved to 6.0%. Renal dysfunction showed no progression for 15 years. At 62 years of age, a second renal biopsy was performed. Glomerular lesions did not show progression but tubulointerstitial fibrosis and vascular lesions showed progression compared with the first biopsy...
2018: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29330824/colonic-fistula-caused-by-remaining-inflow-cannula-14%C3%A2-years-after-left-ventricular-assist-device-explantation
#4
Shunsuke Saito, Koichi Toda, Shigeru Miyagawa, Yasushi Yoshikawa, Hiroki Hata, Keitaro Domae, Ryohei Matsuura, Yoshiki Sawa
Intestinal complication associated with left ventricular assist device (LVAD) implantation is not rare, and sometimes results in serious condition of patients, if occurred. We report a rare case in which remaining foreign body after LVAD explantation resulted in colonic fistula 14 years after LVAD explantation.
January 12, 2018: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/29329906/development-of-a-quick-bioassay-for-the-evaluation-of-transmission-properties-of-acquired-prion-diseases
#5
Yoshiko Munesue, Taishi Shimazaki, Zechen Qi, Norikazu Isoda, Hirofumi Sawa, Keisuke Aoshima, Takashi Kimura, Shirou Mohri, Tetsuyuki Kitamoto, Atsushi Kobayashi
Evaluation of transmission properties is important for the differential diagnosis of a subgroup of acquired Creutzfeldt-Jakob disease (CJD) with methionine homozygosity at polymorphic codon 129 of the PRNP gene, an intermediate type abnormal prion protein (PrP), and kuru plaques, denoted as acquired CJD-MMiK. The present study aimed to develop a quick evaluation system of the transmission properties of acquired CJD-MMiK. In the PrP-humanized mice intraperitoneally inoculated with brain homogenates from an acquired CJD-MMiK patient, accumulation of abnormal PrP was observed in follicular dendritic cells of the spleen at 75 days post-inoculation...
January 9, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29327754/affinity-resins-as-new-tools-for-identifying-target-proteins-of-ascorbic-acid
#6
Yuji Iwaoka, Kohei Nishino, Takahiro Ishikawa, Hideyuki Ito, Yoshihiro Sawa, Akihiro Tai
l-Ascorbic acid (AA) has diverse physiological functions, but little is known about the functional mechanisms of AA. In this study, we synthesized two types of affinity resin on which AA is immobilized in a stable form to identify new AA-targeted proteins, which can provide important clues for elucidating unknown functional mechanisms of AA. To our knowledge, an affinity resin on which AA as a ligand is immobilized has not been prepared, because AA is very unstable and rapidly degraded in an aqueous solution...
January 12, 2018: Analyst
https://www.readbyqxmd.com/read/29316629/increase-of-salt-tolerance-in-carbon-starved-cells-of-rhodopseudomonas-palustris-depending-on-photosynthesis-or-respiration
#7
Sawa Wasai, Nanako Kanno, Katsumi Matsuura, Shin Haruta
Bacteria in natural environments are frequently exposed to nutrient starvation and survive against environmental stresses under non-growing conditions. In order to determine the energetic influence on survivability during starvation, changes in salt tolerance were investigated using the purple photosynthetic bacterium Rhodopseudomonas palustris after carbon starvation under photosynthetic conditions in comparison with anaerobic and aerobic dark conditions. Tolerance to a treatment with high concentration of salt (2...
January 6, 2018: Microorganisms
https://www.readbyqxmd.com/read/29311509/7-azaindole-a-versatile-scaffold-for-developing-kinase-inhibitors
#8
Takayuki Irie, Masaaki Sawa
The majority of kinase inhibitors have been developed as ATP competitors to interact with a hinge region in ATP binding sites of kinases. 7-Azaindole has been found as an excellent hinge binding motif by making two hydrogen bonds with the kinase hinge region. Vemurafenib, a B-RAF kinase (serine-threonine kinase [STK]) inhibitor approved by the U.S. Food and Drug Administration (FDA) for the treatment of melanoma, was created from this simple 7-azaindole fragment by successful use of structure-based drug design techniques...
2018: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29302944/restrictive-mitral-annuloplasty-with-or-without-papillary-muscle-approximation-for-functional-mitral-regurgitation
#9
Yusuke Misumi, Takafumi Masai, Koichi Toda, Teruya Nakamura, Shigeru Miyagawa, Yasushi Yoshikawa, Satsuki Fukushima, Shunsuke Saito, Keitaro Domae, Satoshi Kainuma, Takayoshi Ueno, Toru Kuratani, Takashi Daimon, Yoshiki Sawa
BACKGROUND: The impact of adding papillary muscle approximation (PMA) to restrictive mitral annuloplasty (RMA) on postoperative left ventricular (LV) function is unknown. Changes in LV function parameters and clinical outcome were evaluated following RMA with and without PMA in patients with clinically relevant functional mitral regurgitation (FMR). METHODS: A total of 176 patients with advanced cardiomyopathy underwent RMA either with (n = 59) or without (n = 117) PMA...
July 2017: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/29284387/optimal-time-for-pharmacological-treatment-of-abdominal-aortic-aneurysm
#10
Yasunori Iida, Shigeharu Sawa, Hideyuki Shimizu
Abdominal aortic aneurysm (AAA), if left untreated, poses the main risks of progressive expansion, rupture, and hemorrhage, leading to death. Smoking and hypertension are the 2 major risk factors for AAA crucial in preventing its progression. The underlying fundamental pathophysiological cause of AAA is chronic inflammation. Large AAA with a risk of rupture is usually treated by graft replacement or endovascular aneurysm repair. Nonsurgical treatment is not an alternative for large AAA, but is potentially beneficial for small AAA which usually requires a watchful waiting approach with medication...
December 27, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/29281614/potential-contribution-of-erythrocyte-microrna-to-secondary-erythrocytosis-and-thrombocytopenia-in-congenital-heart-disease
#11
Nobuhiro Mukai, Yoshinobu Nakayama, Satoshi Murakami, Toshihito Tanahashi, Daniel I Sessler, Sachiyo Ishii, Satoru Ogawa, Natsuko Tokuhira, Toshiki Mizobe, Teiji Sawa, Yasufumi Nakajima
BACKGROUND: Children with cyanotic heart disease develop secondary erythrocytosis and thrombocytopenia via unknown mechanisms. Mature erythrocyte microRNAs may reflect clinical pathologies and cell differentiation processes pre-enucleation. This study evaluated erythrocyte microRNAs in children with cyanotic heart disease. METHODS: Erythrocyte microRNAs from children with cyanotic and acyanotic heart disease and without cardiac disease were quantified with Ion PGM System (n=10 per group)...
December 27, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29279483/radiation-pneumonitis-with-eosinophilic-alveolitis-in-a-lung-cancer-patient
#12
Yuki Hosono, Nobuhiko Sawa, Saeko Nakatsubo, Mikako Ishijima, Takeshi Uenami, Masaki Kanazu, Yuki Akazawa, Yukihiro Yano, Masahide Mori, Toshihiko Yamaguchi, Soichiro Yokota
A 59-year-old woman suffering from dry cough and dyspnea was admitted to our hospital. She had undergone concurrent chemo-radiotherapy five months earlier. Chest computed tomography revealed bilateral ground-glass opacities extending outside the irradiated lung field. Her eosinophil numbers were increased in both the peripheral blood and the bronchoalveolar lavage fluid; therefore, she was diagnosed with radiation pneumonitis accompanied by eosinophilic alveolitis. Steroid therapy promptly improved the pneumonitis...
December 27, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29277363/anatomic-feature-of-deltoid-ligament-attachment-in-posteromedial-osteochondral-lesion-of-talar-dome
#13
Tomoyuki Nakasa, Mikiya Sawa, Yasunari Ikuta, Masahiro Yoshikawa, Yusuke Tsuyuguchi, Nobuo Adachi
BACKGROUND: Osteochondral lesions of the talus (OLT) are recognized as being commonly associated with trauma. However, the etiology of OLT remains unclear. In the case of a posteromedial lesion of OLT (medial OLT), the deep layer of the deltoid ligament is located close to the medial OLT, and this relationship between a medial lesion and deltoid ligament could be a risk factor for medial OLT. The purpose of this study is to investigate the unique anatomic feature of the deep deltoid attachment to the talus in patients with medial OLT compared with patients with non-medial OLT...
December 22, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/29276022/brentuximab-vedotin-plus-bendamustine-in-relapsed-or-refractory-hodgkin-s-lymphoma-an-international-multicentre-single-arm-phase-1-2-trial
#14
Owen A O'Connor, Jennifer K Lue, Ahmed Sawas, Jennifer E Amengual, Changchun Deng, Matko Kalac, Lorenzo Falchi, Enrica Marchi, Ithamar Turenne, Renee Lichtenstein, Celeste Rojas, Mark Francescone, Lawrence Schwartz, Bin Cheng, Kerry J Savage, Diego Villa, Michael Crump, Anca Prica, Vishal Kukreti, Serge Cremers, Joseph M Connors, John Kurvuilla
BACKGROUND: Brentuximab vedotin is currently approved for patients with relapsed or refractory Hodgkin's lymphoma who previously received an autologous stem cell transplant or two previous multiagent chemotherapy regimens, and for patients with relapsed or refractory systemic anaplastic large-T-cell lymphoma who previously received at least one chemotherapy regimen. A high proportion of patients with CD30-expressing relapsed or refractory lymphomas have durable responses to single-agent brentuximab vedotin and show longer progression-free survival than do patients treated with chemotherapy...
December 21, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/29260793/corrigendum-structures-and-biological-activities-of-novel-4-acetylated-analogs-of-chrysomycins-a-and-b
#15
Shun-Ichi Wada, Ryuichi Sawa, Fumiki Iwanami, Miho Nagayoshi, Yumiko Kubota, Kiyoko Iijima, Chigusa Hayashi, Yuko Shibuya, Masaki Hatano, Masayuki Igarashi, Manabu Kawada
This corrects the article DOI: 10.1038/ja.2017.99.
December 2017: Journal of Antibiotics
https://www.readbyqxmd.com/read/29259459/assisted-reproductive-technology-in-japan-a-summary-report-of-1992-2014-by-the-ethics-committee-japan-society-of-obstetrics-and-gynecology
#16
Minoru Irahara, Akira Kuwahara, Takeshi Iwasa, Tomonori Ishikawa, Osamu Ishihara, Koji Kugu, Rintaro Sawa, Kouji Banno, Hidekazu Saito
Aim: The Japan Society of Obstetrics and Gynecology implemented a registry report system for the clinical practice of assisted reproductive technology in 1986. The aggregated results from 1992 to 2014 are reported herein. Methods and Results: The total number of registered treatments was 393 745 cycles, of which 66 550 were pregnancy cycles and 46 008 were cycles with a live birth. Compared to the number of registered treatments in 2008, when the cycle-based registry was newly introduced, there was a 2...
April 2017: Reproductive Medicine and Biology
https://www.readbyqxmd.com/read/29258821/involvement-of-nitric-oxide-reactive-oxygen-species-signaling-via-8-nitro-cgmp-formation-in-1-methyl-4-phenylpyridinium-ion-induced-neurotoxicity-in-pc12-cells-and-rat-cerebellar-granule-neurons
#17
Kumiko Masuda, Hiroyasu Tsutsuki, Shingo Kasamatsu, Tomoaki Ida, Tsuyoshi Takata, Kikuya Sugiura, Motohiro Nishida, Yasuo Watanabe, Tomohiro Sawa, Takaaki Akaike, Hideshi Ihara
To investigate the role of nitric oxide (NO)/reactive oxygen species (ROS) redox signaling in Parkinson's disease-like neurotoxicity, we used 1-methyl-4-phenylpyridinium (MPP+) treatment (a model of Parkinson's disease). We show that MPP+-induced neurotoxicity was dependent on ROS from neuronal NO synthase (nNOS) in nNOS-expressing PC12 cells (NPC12 cells) and rat cerebellar granule neurons (CGNs). Following MPP+ treatment, we found production of 8-nitroguanosine 3',5'-cyclic monophosphate (8-nitro-cGMP), a second messenger in the NO/ROS redox signaling pathway, in NPC12 cells and rat CGNs, that subsequently induced S-guanylation and activation of H-Ras...
December 16, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29251645/dopamine-d2-receptor-antagonist-droperidol-deepens-sevoflurane-anesthesia
#18
Ryuhei Araki, Kazuko Hayashi, Teiji Sawa
BACKGROUND: Although midbrain dopaminergic pathways are known to contribute to arousal and emergence from anesthesia, few reports exist regarding the anesthetic effects of dopamine D2 receptor antagonism in humans. This study examined the effect of the D2 receptor antagonist droperidol on sevoflurane anesthesia by examining α and slow wave electroencephalogram oscillations. METHODS: Forty-five patients, age 20 to 60 yr, were enrolled. Frontal electroencephalograms were continuously collected for offline analysis via Bispectral Index monitoring...
December 15, 2017: Anesthesiology
https://www.readbyqxmd.com/read/29248418/evaluation-of-the-modified-carbapenem-inactivation-method-for-the-detection-of-carbapenemase-producing-enterobacteriaceae
#19
Tomokazu Kuchibiro, Masaru Komatsu, Katsutoshi Yamasaki, Tatsuya Nakamura, Hisaaki Nishio, Isao Nishi, Keigo Kimura, Makoto Niki, Tamotsu Ono, Noriyuki Sueyoshi, Machiko Kita, Kaneyuki Kida, Masanobu Ohama, Kaori Satoh, Hirofumi Toda, Tetsu Mizutani, Nozomi Fukuda, Kana Sawa, Isako Nakai, Tomomi Kofuku, Tamaki Orita, Hideo Watari, Satoshi Shimura, Saori Fukuda, Akihiro Nakamura, Yasunao Wada
Carbapenemase-producing Enterobacteriaceae (CPE) are increasing worldwide. Rapid and accurate detection of CPE is necessary for appropriate antimicrobial treatment and hospital infection control. However, CPE contains some strains that are difficult to detect depending on genotype and MIC value of carbapenem, and a detection method has not been established. The recently reported modified carbapenem inactivation method (mCIM) has been developed in CLSI M100-S27 as a phenotypic technique for detecting carbapenemase activity...
December 13, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29242310/approaches-to-neuromodulation-for-schizophrenia
#20
REVIEW
Judith M Gault, Rachel Davis, Nicola G Cascella, Elyn R Saks, Iluminada Corripio-Collado, William S Anderson, Ann Olincy, John A Thompson, Edith Pomarol-Clotet, Akira Sawa, Zafiris J Daskalakis, Nir Lipsman, Aviva Abosch
Based on the success of deep brain stimulation (DBS) for treating movement disorders, there is growing interest in using DBS to treat schizophrenia (SZ). We review the unmet needs of patients with SZ and the scientific rationale behind the DBS targets proposed in the literature in order to guide future development of DBS to treat this vulnerable patient population. SZ remains a devastating disorder despite treatment. Relapse, untreated psychosis, intolerable side effects and the lack of effective treatment for negative and cognitive symptoms contribute to poor outcome...
December 14, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
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