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https://www.readbyqxmd.com/read/28211472/proteolysis-regulates-cardiomyocyte-maturation-and-tissue-integration
#1
Ryuichi Fukuda, Felix Gunawan, Arica Beisaw, Vanesa Jimenez-Amilburu, Hans-Martin Maischein, Sawa Kostin, Koichi Kawakami, Didier Y R Stainier
Tissue integrity is critical for organ formation and function. During heart development, cardiomyocytes differentiate and integrate to form a coherent tissue that contracts synchronously. However, the molecular mechanisms regulating cardiac tissue integrity are poorly understood. Here we show that proteolysis, via the E3 ubiquitin ligase ASB2, regulates cardiomyocyte maturation and tissue integrity. Cardiomyocytes in asb2b zebrafish mutants fail to terminally differentiate, resulting in reduced cardiac contractility and output...
February 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/28197965/allogeneic-stem-cell-transplantation-for-adult-patients-with-acute-lymphoblastic-leukemia-who-had-central-nervous-system-involvement-a-study-from-the-adult-all-working-group-of-the-japan-society-for-hematopoietic-cell-transplantation
#2
Akio Shigematsu, Shinichi Kako, Kenjiro Mitsuhashi, Koji Iwato, Naoyuki Uchida, Yoshinobu Kanda, Takahiro Fukuda, Masashi Sawa, Yasushi Senoo, Hiroyasu Ogawa, Koichi Miyamura, Satoru Takada, Tokiko Nagamura-Inoue, Yasuo Morishima, Tatsuo Ichinohe, Yoshiko Atsuta, Shuichi Mizuta, Junji Tanaka
The prognosis for adult acute lymphoblastic leukemia (ALL) patients with central nervous system (CNS) involvement (CNS+) who received allogeneic hematopoietic stem cell transplantation (allo-SCT) remains unclear. We retrospectively compared the outcomes of allo-SCT for patients with CNS involvement and for patients without CNS involvement (CNS-) using a database in Japan. The eligibility criteria for this study were as follows: diagnosis of ALL, aged more than 16 years, allo-SCT between 2005 and 2012, and first SCT...
February 14, 2017: International Journal of Hematology
https://www.readbyqxmd.com/read/28197736/journal-of-artificial-organs-2016-the-year-in-review-journal-of-artificial-organs-editorial-committee
#3
REVIEW
Y Sawa, G Matsumiya, K Matsuda, E Tatsumi, T Abe, K Fukunaga, S Ichiba, A Kishida, K Kokubo, T Masuzawa, A Myoui, M Nishimura, T Nishimura, T Nishinaka, E Okamoto, S Tokunaga, T Tomo, T Tsukiya, Y Yagi, T Yamaoka
No abstract text is available yet for this article.
February 14, 2017: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/28196979/acremopeptin-a-new-peptaibol-from-acremonium-sp-pf1450
#4
Masatomi Iijima, Masahide Amemiya, Ryuichi Sawa, Yumiko Kubota, Takao Kunisada, Isao Momose, Manabu Kawada, Masakatsu Shibasaki
No abstract text is available yet for this article.
February 15, 2017: Journal of Antibiotics
https://www.readbyqxmd.com/read/28191970/various-arsenic-network-structures-in-112-type-ca1-xlaxfe1-ypdyas2-revealed-by-synchrotron-x-ray-diffraction-experiments
#5
Shinya Tamura, Naoyuki Katayama, Yuto Yamada, Yuki Sugiyama, Kento Sugawara, Hiroshi Sawa
Two novel 112-type palladium-doped iron arsenides were synthesized and identified using comprehensive studies involving synchrotron X-ray diffraction and X-ray absorption near-edge structure (XANES) experiments. Whereas in-plane arsenic zigzag chains were found in the 112-type superconducting iron arsenide Ca1-xLaxFeAs2 with maximum Tc = 34 K, deformed arsenic network structures appeared in other 112-type materials, such as longitudinal arsenic zigzag chains in CaFe1-yPdyAs2 (y ∼ 0.51) and arsenic square sheets constructed via hypervalent bonding in Ca1-xLaxFe1-yPdyAs2 (x ∼ 0...
February 13, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28190706/long-term-patency-of-arteriovenous-fistulae-salvaged-by-balloon-angioplasty-with-and-without-accessory-vein-embolization-a-retrospective-study
#6
Ayman Sawas, Timothy M Baran, Thomas H Foster, Joseph Reis, Richard E Wing, Randeep Kashyap, David Brhel, Talia Sasson
PURPOSE: To investigate whether accessory vein embolization (AVE) improves long-term performance of salvaged nonmaturing arteriovenous fistulae (AVFs). MATERIALS AND METHODS: This retrospective review included 72 patients who underwent percutaneous balloon angioplasty for salvage of nonmaturing AVFs between 2008 and 2014. AVE was performed on 32 patients between 2008 and 2011 (mean age, 59 y [range, 33-85 y]; men, n = 21; women, n = 11; upper arm, n = 17; forearm, n = 15), whereas the procedure was not performed on 40 patients after 2011 (mean age, 62 y [range, 28-85 y]; men, n = 26; women, n = 14; upper arm, n = 26; forearm, n = 14)...
February 9, 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/28186651/rapid-immunocytochemistry-for-the-detection-of-cytokeratin-and-vimentin-assessment-of-its-diagnostic-value-in-neoplastic-diseases-of-dogs
#7
Mariko Sawa, Mayuko Inoue, Akira Yabuki, Moeko Kohyama, Noriaki Miyoshi, Asuka Setoguchi, Osamu Yamato
BACKGROUND: Immunocytochemistry (ICC) is an advanced diagnostic technique used in the field of veterinary cytology. We recently developed a rapid ICC method for the detection of cytokeratin and vimentin in dogs, which helps to determine whether tumor cells are of epithelial or nonepithelial origin. However, the diagnostic value of this rapid ICC method in neoplastic diseases of dogs has not been assessed yet. OBJECTIVES: The aim of the present study was to assess the diagnostic accuracy of rapid ICC compared to standard immunohistochemistry (IHC)...
February 10, 2017: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/28185057/the-dynamic-changes-of-cd3e-cd11c-dendritic-cells-in-spleens-and-bone-marrow-of-mice-infected-with-schistosoma-japonicum
#8
Lin Chen, Qingzhou Chen, Wei Hou, Li He
Schistosoma japonicum as a pathogeny requires dendritic cells to activate immune response. So, the research is to study the dynamic changes of CD3e(-)CD11c(+) dendritic cells in mice infected with S. japonicum. Zero, 7, 28, 35, and 63 days were selected to study the variation of dendritic cells, and the proportions of CD3e(-)CD11c(+) dendritic cells and CD86(+) mature dendritic cells in spleens and bone marrow were tested by flow cytometry. As a result, the variation trends of dendritic cells in spleen and bone marrow are similar as follows: the proportions of CD3e(-)CD11c(+) dendritic cells increased first and then decreased from day 35, but the percentages of CD86(+) mature dendritic cells decreased from day 28 and increased in day 63...
February 10, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28174422/antarlides-f-h-new-members-of-the-antarlide-family-produced-by-streptomyces-sp-bb47
#9
Shun Saito, Takahiro Fujimaki, Watanalai Panbangred, Ryuichi Sawa, Yasuhiro Igarashi, Masaya Imoto
Castration-resistant prostate cancer (CRPC) is the most aggressive form of this disease. CRPC remains dependent on androgen receptor (AR) signaling. Therefore, a novel AR antagonist, enzalutamide, is used clinically for the treatment of men with metastatic CRPC. However, enzalutamide-resistant AR has appeared, and a new type of AR antagonist is desired. Previously, in the course of screening for a new type of AR antagonist, we isolated a series of compounds, designated antarlides A-E, that share a novel 22-membered-ring macrocyclic structure and are produced by Streptomyces sp...
February 8, 2017: Journal of Antibiotics
https://www.readbyqxmd.com/read/28174390/-surgical-regeneration-therapy-using-myoblast-sheets-for-severe-heart-failure
#10
Yoshiki Sawa
Heart failure is a life-threatening disorder worldwide, and the current end-stage therapies for severe heart failure are replacement therapies such as ventricular-assist devices and heart transplantation. Although these therapies have been reported to be useful, there are many issues in terms of the durability, complications, limited donors, adverse effect of continuous administration of immunosuppressive agents, and high costs involved. Recently, regenerative therapy based on genetic, cellular, or tissue engineering techniques has gained attention as a new therapy to overcome the challenges encountered in transplantation medicine...
January 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/28174332/spiritual-well-being-and-correlated-factors-in-subjects-with-advanced-copd-or-lung-cancer
#11
Takaaki Hasegawa, Momoko Kawai, Nanori Kuzuya, Yohei Futamura, Akane Horiba, Takashi Ishiguro, Tsutomu Yoshida, Toshiyuki Sawa, Yasuyuki Sugiyama
BACKGROUND: Spiritual care for patients with COPD has rarely been discussed, and thus much remains unknown about their needs. The aims of this study were to identify the factors associated with spiritual well-being and to compare the levels of spiritual well-being between subjects with advanced COPD and those with inoperable lung cancer. METHODS: A total of 96 subjects with COPD or lung cancer participated in this study, which was conducted between December 2014 and April 2016...
February 7, 2017: Respiratory Care
https://www.readbyqxmd.com/read/28171877/a-multicenter-randomized-controlled-study-of-antioxidant-supplementation-with-lutein-for-chronic-central-serous-chorioretinopathy
#12
Ari Shinojima, Miki Sawa, Tetsuju Sekiryu, Yuji Oshima, Ryusaburo Mori, Chikako Hara, Yukinori Sugano, Aki Kato, Hitomi Asato, Mitsuko Yuzawa, Fumi Gomi, Yuichiro Ogura, Tatsuro Ishibashi, Tomoaki Nanri, Tsutomu Yasukawa
PURPOSE: To investigate functional and morphological changes in patients with chronic central serous chorioretinopathy after supplementation with antioxidants containing lutein or a placebo. PROCEDURES: One hundred eyes of 100 patients were randomly divided into 2 groups, one taking tablets with lutein plus other antioxidants and the other taking a placebo for 6 months. Best-corrected visual acuity (BCVA) and the subfoveal fluid height on optical coherence tomography were measured...
February 8, 2017: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/28169324/metabolomic-profiling-of-reactive-persulfides-and-polysulfides-in-the-aqueous-and-vitreous-humors
#13
Hiroshi Kunikata, Tomoaki Ida, Kota Sato, Naoko Aizawa, Tomohiro Sawa, Hiroshi Tawarayama, Namie Murayama, Shigemoto Fujii, Takaaki Akaike, Toru Nakazawa
We investigate the metabolomic profile of reactive persulfides and polysulfides in the aqueous and vitreous humors. Eighteen eyes of 18 consecutive patients with diabetes mellitus (DM) and diabetic retinopathy underwent microincision vitrectomy combined with cataract surgery. Samples of the aqueous and vitreous humors were collected and underwent mass spectrometry-based metabolomic profiling of reactive persulfides and polysulfides (polysulfidomics). The effect of reactive polysulfide species on the viability of immortalized retinal cells (the RGC-5 cell line) under oxidative stress (induced with H2O2) was also evaluated with an Alamar Blue assay...
February 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28168662/multicentric-castleman-s-disease-associated-with-iga-vasculitis-henoch-sch%C3%A3-nlein-purpura-responding-well-to-tocilizumab-a-case-report
#14
REVIEW
Yoichi Oshima, Junichi Hoshino, Tatsuya Suwabe, Noriko Hayami, Masayuki Yamanouchi, Akinari Sekine, Toshiharu Ueno, Hiroki Mizuno, Junko Yabuuchi, Aya Imafuku, Masahiro Kawada, Rikako Hiramatsu, Eiko Hasegawa, Naoki Sawa, Kenmei Takaichi, Nobukazu Hayashi, Takeshi Fujii, Yoshifumi Ubara
A 41-year-old man was referred to our hospital for the evaluation of hypergammaglobulinemia (IgG 2898 mg/dL and IgA 587 mg/dL), inflammation (CRP 6.7 mg/dL and serum interleukin-6 (IL-6) 15.1 ng/L), and anemia (Hb 10.9 mg/dL). Castleman's disease (CD) was diagnosed by axillary lymph node biopsy. Five months later, painful purpura (multiple palpable 5 mm lesions) developed on his legs, gradually spreading to the upper limbs, thighs, and trunk, accompanied by arthralgia of the wrists, ankles, and knees...
February 6, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28166673/predictors-of-surgeons-efficiency-in-the-operating-rooms
#15
Yoshinori Nakata, Yuichi Watanabe, Hiroto Narimatsu, Tatsuya Yoshimura, Hiroshi Otake, Tomohiro Sawa
The sustainability of the Japanese healthcare system is questionable because of a huge fiscal debt. One of the solutions is to improve the efficiency of healthcare. The purpose of this study is to determine what factors are predictive of surgeons' efficiency scores. The authors collected data from all the surgical procedures performed at Teikyo University Hospital from April 1 through September 30 in 2013-2015. Output-oriented Charnes-Cooper-Rhodes model of data envelopment analysis was employed to calculate each surgeon's efficiency score...
February 2017: Health Services Management Research
https://www.readbyqxmd.com/read/28161817/curative-surgery-for-gastric-cancer-in-a-patient-with-an-implantable-left-ventricular-assist-device
#16
Yuki Nakamura, Koichi Toda, Teruya Nakamura, Shigeru Miyagawa, Yasushi Yoshikawa, Satsuki Fukushima, Shunsuke Saito, Daisuke Yoshioka, Keitaro Domae, Tsuyoshi Takahashi, Tadayoshi Hashimoto, Yuichiro Doki, Yoshiki Sawa
The number of patients with end-stage heart failure treated by a left ventricular assist device (LVAD) is dramatically increasing, because the LVAD has been widely accepted for its clinical results. According to the initiation of destination therapy, the prevalence of malignancy in patients with an LVAD is estimated to increase. In patients with LVADs, abdominal surgery for visceral malignancy is associated with technical difficulties because of the presence of an LVAD pump or the driveline which is located transversely in the preperitoneal space...
February 4, 2017: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/28154801/pranlukast-reduces-asthma-exacerbations-during-autumn-especially-in-1-to-5-year-old-boys
#17
Yoshinori Morita, Eduardo Campos Alberto, Shuichi Suzuki, Yoshinori Sato, Akira Hoshioka, Hiroki Abe, Kimiyuki Saito, Toshikazu Tsubaki, Mana Haraki, Akiko Sawa, Yoshio Nakayama, Hiroyuki Kojima, Midori Shigeta, Fumiya Yamaide, Yoichi Kohno, Naoki Shimojo
BACKGROUND: Leukotriene receptor antagonists have been used to prevent virus-induced asthma exacerbations in autumn. Its efficacy, however, might differ with age and sex. OBJECTIVE: This study aimed to investigate whether pranlukast added to usual asthma therapy in Japanese children during autumn, season associated with the peak of asthma, reduces asthma exacerbations. It was also evaluated the effect of age and sex on pranlukast's efficacy. METHODS: A total of 121 asthmatic children aged 1 to 14 years were randomly assigned to receive regular pranlukast or not according to sex, and were divided in 2 age groups, 1-5 years and 6-14 years...
January 2017: Asia Pacific Allergy
https://www.readbyqxmd.com/read/28153167/intermittent-hypoxia-causes-mandibular-growth-retardation-and-macroglossia-in-growing-rats
#18
Jun Hosomichi, Yo-Ichiro Kuma, Shuji Oishi, Hisashi Nagai, Hideyuki Maeda, Risa Usumi-Fujita, Yasuhiro Shimizu, Sawa Kaneko, Chisa Shitano, Jun-Ichi Suzuki, Ken-Ichi Yoshida, Takashi Ono
INTRODUCTION: In this study, we aimed to examine the role of intermittent hypoxia (IH) in dentofacial morphologic changes in growing rats. METHODS: Seven-week-old male rats were exposed to IH at 20 cycles per hour (nadir of 4% oxygen to peak of 21% oxygen) for 8 hours per day for 6 weeks. Control rats were exposed to normoxia (N). Maxillofacial growth was compared between the 2 groups by linear measurements on cephalometric radiographs. To examine the dental arch morphology, study models and microcomputed tomography images of the jaws were taken...
February 2017: American Journal of Orthodontics and Dentofacial Orthopedics
https://www.readbyqxmd.com/read/28126743/superoxide-generation-from-nnos-splice-variants-and-its-potential-involvement-in-redox-signal-regulation
#19
Hideshi Ihara, Atsushi Kitamura, Shingo Kasamatsu, Tomoaki Ida, Kakihana Yuki, Hiroyasu Tsutsuki, Tomohiro Sawa, Yasuo Watanabe, Takaaki Akaike
We previously demonstrated different spacial expression profiles of the neuronal nitric oxide (NO) synthase (nNOS) splice variants nNOS-μ and nNOS-α in the brain; however, their exact functions are not fully understood.  Here, we used electron paramagnetic resonance to compare the electron-uncoupling reactions of recombinant nNOS-μ and nNOS-α that generate reactive oxygen species (ROS), in this case, superoxide.  nNOS-µ generated 44% of the amount of superoxide that nNOS-α generated.  We also evaluated the ROS production in HEK293 cells stably expressing nNOS-α and nNOS-μ by investigating these electron-uncoupling reactions as induced by calcium ionophore, A23187...
January 26, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28123149/clinical-outcomes-and-bioprosthetic-valve-function-after-transcatheter-aortic-valve-implantation-under-dual-antiplatelet-therapy-vs-aspirin-alone
#20
Yasuhiro Ichibori, Isamu Mizote, Koichi Maeda, Toshinari Onishi, Tomohito Ohtani, Osamu Yamaguchi, Kei Torikai, Toru Kuratani, Yoshiki Sawa, Satoshi Nakatani, Yasushi Sakata
BACKGROUND: Dual antiplatelet therapy (DAPT) is commonly used after transcatheter aortic valve implantation (TAVI); however, the supporting evidence is limited. To determine if aspirin alone is a better alternative to DAPT, we compared the outcomes of patients treated with DAPT or aspirin alone after TAVI.Methods and Results:We analyzed a total of 144 consecutive patients (92 females, mean age 83±6 years) who underwent implantation of a balloon-expandable transcatheter valve (SAPIEN or SAPIEN XT, Edwards Lifesciences)...
January 24, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
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