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https://www.readbyqxmd.com/read/28929221/therapeutic-modalities-and-oncologic-outcomes-in-the-treatment-of-t1b-glottic-squamous-cell-carcinoma-a-systematic-review
#1
REVIEW
Federico Maria Gioacchini, Michele Tulli, Shaniko Kaleci, Stefano Bondi, Mario Bussi, Massimo Re
T1a and T1b glottic squamous cell carcinoma (SCC) are often analyzed together by authors who investigate the oncologic outcomes achieved after different therapeutic options. Nevertheless, T1b definitely represents a more advanced tumor stage compared to T1a glottic SCC. The objective of this review was first to analyze the overall success rates in the treatment of patients affected by T1b glottic SCC. Moreover, a subgroup analysis was planned to specifically compare the outcomes obtained with radiotherapy (RT), transoral laser microsurgery (TLM) and open partial laryngectomies (OPL)...
September 19, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28904716/-supracricoid-partial-laryngectomy-scpl-with-either-cricohyoidoepiglottopexy-chep-our-experience-with-16-cases
#2
Bouchaib Hemmaoui, Mohamed Sahli, Noureddine Errami, Ahmed Rouihi, Mohamed Habib Bahalou, Ilias Benchaifai, Amine Ennouali, Sara Britel, Ismail Nakkabi, Ali Jahidi, Mohamed Zalagh, Saloua Ouaraini, Fouad Benariba
Partial laryngectomy with either cricohyoidoepiglottopexy (CHEP) are mainly used to treat glottic cancers becuse they ensure a satisfactory preservation of physiological functions and satisfactory local carcinologic control. Our study aimed to analyze the functional and carcinologic results of this surgical technique. We conducted a retrospective study of patients undergoing partial laryngectomy with either cricohyoidoepiglottopexy in our Hospital between 2011 and 2014. We analyzed the epidemiological data, the surgical peculiarities, the functional outcomes and the carcinologic control of the disease...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28895157/laryngeal-exposure-and-margin-status-in-glottic-cancer-treated-by-transoral-laser-microsurgery
#3
Cesare Piazza, Alberto Paderno, Paola Grazioli, Francesca Del Bon, Nausica Montalto, Pietro Perotti, Riccardo Morello, Marta Filauro, Piero Nicolai, Giorgio Peretti
OBJECTIVE: Laryngeal exposure is one of the most limiting factors in transoral laser microsurgery (TLM) for glottic cancer. We evaluated the correlation between the degree of laryngeal exposure, as assessed by an easy previously described scoring tool (Laryngoscore), and histopathologic surgical margin status after TLM. STUDY DESIGN: Prospective evaluation of 147 patients affected by Tis-T2 glottic cancer treated by TLM with curative intent between January 2012 and April 2016...
September 12, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28891087/elucidation-of-salvage-laryngectomy-pathologic-and-clinical-variables-to-guide-further-treatment-intensification-investigation
#4
Joseph Scharpf, Matthew Ward, David Adelstein, Shlomo Koyfman, Mingsi Li
OBJECTIVE/HYPOTHESIS: There are limited treatment options beyond surgical salvage for patients who fail nonoperative treatment for laryngeal squamous cell carcinoma. In this study, we examine the failure patterns after surgical salvage and the potential pathologic and clinical prognostic variables that might guide further postoperative intensification investigation. STUDY DESIGN: Retrospective analysis at a tertiary academic referral center. METHODS: From an institutional review board-approved institutional head and neck cancer registry, a consecutive series of 147 patients who underwent salvage laryngectomy for squamous cell cancer recurrence or persistence after radiotherapy with or without chemotherapy between May 1995 and May 2016 were identified...
September 11, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28880984/association-of-a-perioperative-education-program-with-unplanned-readmission-following-total-laryngectomy
#5
Evan M Graboyes, Dorina Kallogjeri, Jan Zerega, Sara Kukuljan, Linda Neal, Kelsey M Rosenquist, Brian Nussenbaum
Importance: Patients undergoing total laryngectomy (TL) are at high risk for 30-day hospital readmission. Strategies to decrease the readmission rate remain unknown. Objectives: To assess the association of a comprehensive perioperative TL education program with unplanned readmissions; to determine the program's association with the rate of readmissions for stomal or tracheoesophageal puncture (TEP) complications and patient and caregiver knowledge of and preparedness for TL...
September 7, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28872157/laryngectomy-what-is-the-impact-of-the-type-of-surgery-on-life-quality-and-sexual-function
#6
F Akil, U Yollu, S F Toprak, M Ayral
The purpose of this study is to compare total and partial larygectomy on private life functions and sexuality in patients with laryngeal cancer. The study included 31 partial laryngectomy patients (Group 1) and 51 total laryngectomy patients (Group 2) who were operated for laryngeal cancer. European Organization for Research and Treatment of Cancer (EORTC) head and neck cancer module (QLQ-H&N35) and Arizona Sexual Experiences Scale (ASEX) forms were filled in by interviewing face to face with patients. HNSW (swallowing), HNSE (senses), HNSP (speech), HNSO (social eating), HNSX (sexuality), HNTE (problems with teeth), HNOM (problems with opening mouth) and HNCO (coughing) scores of EORTC QLQ-H&N35 were significantly higher in group 2 than in group 1...
August 2017: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/28870931/long-term-clinical-results-of-concurrent-chemoradiotherapy-for-patients-with-cervical-esophageal-squamous-cell-carcinoma
#7
Atsuhiro Kumabe, Sadatomo Zenda, Atsushi Motegi, Masakatsu Onozawa, Naoki Nakamura, Takashi Kojima, Hiroyuki Daiko, Naoyuki Shigematsu, Tetsuo Akimoto
BACKGROUND/AIM: We assessed the efficacy and toxicity of concurrent chemoradiotherapy (CCRT) in patients with squamous cell carcinoma of the cervical esophagus. PATIENTS AND METHODS: We retrospectively analyzed 37 patients treated with definitive CCRT. The patients received radiotherapy at a fraction dose of 2 Gy (total; 60 or 70 Gy) and concurrent chemotherapy. Adjuvant chemotherapy consisted of 1 to 2 cycles of 5-fluorouracil plus cisplatin or nedaplatin. RESULTS: The median follow-up was 119...
September 2017: Anticancer Research
https://www.readbyqxmd.com/read/28865969/-role-and-interest-of-induction-chemotherapy-for-head-and-neck-cancers
#8
Y Pointreau, U Schick, F Huguet
Induction chemotherapy must be integrated in a global approach for locally advanced head and neck cancer. Its use has theoretical advantages but should not compromise locoregional radiotherapy. Induction chemotherapy is a standard for organ preservation with the use of the TPF scheme to avoid total laryngectomy without compromising survival data. It is more controversial in other locally advanced head and neck cancer because concurrent chemoradiotherapy is the standard of care. It may be an option for patients with significant lymph node invasion to reduce the occurrence of distant metastasis...
August 30, 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28865840/efficacy-of-the-myofascial-pectoralis-major-flap-in-the-reduction-of-salivary-fistulas-after-salvage-total-laryngectomy
#9
Carlos Miguel Chiesa Estomba, Jose Angel González García, Jon Alexander Sistiaga Suarez, Izaskun Thomas Arrizabalaga, Ekhiñe Larruscain Sarasola, Xabier Altuna Mariezcurrena
INTRODUCTION: Pharyngocutaneous fistula is the most frequent complication after total laryngectomy. Its incidence varies between 9%-25% in post primary total laryngectomy patients, to 14%-57% in salvage laryngectomy post radiotherapy or post chemotherapy + radiotherapy. The pectoralis major myofascial flap (PMMF)is postulated as a useful tool to decrease the incidence of this complication. MATERIALS AND METHOD: Retrospective analysis of a group of patients treated by salvage laryngectomy, associated or not with pharyngeal closure reinforcement with PMMF...
August 30, 2017: Acta Otorrinolaringológica Española
https://www.readbyqxmd.com/read/28863776/a-change-in-the-study-evaluation-paradigm-reveals-that-larynx-preservation-compromises-survival-in-t4-laryngeal-cancer-patients
#10
Gerhard Dyckhoff, Peter K Plinkert, Heribert Ramroth
BACKGROUND: Larynx preservation (LP) is recommended for up to low-volume T4 laryngeal cancer as an evidence-based treatment option that does not compromise survival. However, a reevaluation of the current literature raises questions regarding whether there is indeed reliable evidence to support larynx preservation for T4 tumor patients. METHODS: In an observational cohort study of 810 laryngeal cancer patients, we evaluated the outcomes of all T4 tumor patients treated with primary chemo-radiotherapy (CRT) or primary radiotherapy alone (RT) compared with upfront total laryngectomy followed by adjuvant (chemo)radiotherapy (TL + a[C]RT)...
September 1, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28843218/clinicopathologic-findings-and-treatment-outcome-of-laryngectomized-patients-with-laryngeal-cancer-and-hypopharyngeal-cancer-an-experience-in-thailand
#11
Noppadol Larbcharoensub, Duangkamon Wattanatranon, Juvady Leopairut, Suwimon Suntisuktana, Boonsam Roongpupaht, Chalermchai Chintrakarn, Jumroon Tungkeeratichai, Phurich Praneetvatakul, Thongchai Bhongmakapat, Wichit Cheewaruangroj, Supawadee Prakunhungsit
Objective: To evaluate the clinicopathologic findings and treatment outcome in laryngectomized patients with laryngeal cancer and hypopharyngeal cancer. Materials and Methods: The authors retrospectively reviewed the medical records of 212 patients who had been newly diagnosed and treated with laryngectomy between January 2000 and December 2010. The age, gender, clinical manifestations, associated predisposing condition, tumor WHO grade, AJCC tumor stage, maximum tumor size, anatomical involvement, type of surgery, postoperative sequelae, treatment and therapeutic outcome were analyzed...
August 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28837753/functional-outcomes-and-quality-of-life-after-total-laryngectomy-with-noncircumferential-radial-forearm-free-tissue-transfer
#12
Donna J Graville, Andrew D Palmer, Christine M Chambers, Lauren Ottenstein, Breanne Whalen, Peter E Andersen, Mark K Wax, James I Cohen
BACKGROUND: The purpose of this study was to compare long-term functional and quality of life (QOL) outcomes after total laryngectomy with primary closure and those who underwent reconstruction with noncircumferential radial free forearm tissue transfer (RFFTT). METHODS: Sixty-seven patients were identified by chart review and underwent long-term follow-up using QOL surveys and standardized interviews. RESULTS: The RFFTT group had significantly higher rates of chemotherapy, gastric tube (G-tube) at surgery, and postoperative stricture...
August 24, 2017: Head & Neck
https://www.readbyqxmd.com/read/28835085/-management-of-t3-supraglottic-carcinoma-a-retrospective-study
#13
W S Liu, Z J Li, G F Zhang, Z G Xu, P Z Tang, G Y Tu
Objective: To discuss the strategy of therapeutic management of T3 supraglottic carcinoma. Methods: A retrospective analysis of 459 patients with T3 supraglottic carcinoma treated in our hospital was performed. We evaluated the results of different managements, including surgery alone, preoperative radiotherapy, postoperative radiotherapy and radiotherapy alone. The extent of the lesion was also put into analysis. Statistical analysis of the overall survival (OS), cause-specific survival (CSS), local control (LC), regional control(RC), function-conservation (FC) were performed with the statistical package from SPSS...
August 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28830509/peri-operative-factors-predisposing-to-pharyngocutaneous-fistula-after-total-laryngectomy-analysis-of-a-large-multi-institutional-patient-cohort
#14
Nicole L Lebo, Lisa Caulley, Hussain Alsaffar, Martin J Corsten, Stephanie Johnson-Obaseki
BACKGROUND: Pharyngocutaneous fistula (PCF) is a problematic complication following total laryngectomy. Disagreement remains regarding predisposing factors. This study examines perioperative factors predicting PCF following total laryngectomy using a large multicenter data registry. METHODS: Retrospective cohort analysis was performed using patients undergoing total laryngectomy in the ACS-NSQIP database for 2006-2014. Sub-analysis was performed based on reconstruction type...
August 23, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28828922/preoperative-counseling-in-salvage-total-laryngectomy-content-analysis-of-electronic-medical-records
#15
Nikhila Raol, Elizabeth Lilley, Zara Cooper, Jayme Dowdall, Megan A Morris
Objective To study preoperative counseling in patients undergoing salvage total laryngectomy (STL). Study Design Case series with chart review. Setting Tertiary care academic hospital. Subjects and Methods We reviewed charts of patients ≥18 years undergoing STL between 2005 and 2015. Fifty-eight patients were identified. Notes written within 2 months prior to surgery by head and neck surgical oncologists, radiation oncologists, medical oncologists, speech-language pathologists, social workers, and nurse practitioners were extracted and coded into 4 categories...
August 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28828918/use-of-ultrasound-for-sizing-tracheoesophageal-puncture-prostheses
#16
Aaron Smith, Vikrum Thimmappa, Julia Jones, Courtney Shires, Merry Sebelik
Tracheoesophageal puncture (TEP) with voice prosthesis placement is the gold standard voice rehabilitation following total laryngectomy. Ultrasound may be useful to determine tracheoesophageal wall thickness, guiding prosthesis choice. Therefore, 14 patients undergoing total laryngectomy and TEP or prosthesis change with 16-mHz ultrasound measurement of the posterior tracheal wall were included. Seven patients underwent secondary TEP, 3 primary TEP, and 4 TEP changes. Six patients underwent flap reconstruction, while 8 patients were closed primarily...
August 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28815835/patient-education-materials-assessment-tool-for-laryngectomy-health-information
#17
Kevin Wong, Amir Gilad, Michael B Cohen, Diana N Kirke, Scharukh M Jalisi
BACKGROUND: The decision to undergo laryngectomy carries medical, social, and emotional consequences. This study evaluates the understandability and actionability of current laryngectomy information. METHODS: Laryngectomy-related educational materials from an online search were evaluated using the validated Patient Education Materials Assessment Tool (PEMAT). Reading difficulty was calculated using the Flesch-Kincaid Level, Flesch Reading Ease, Gunning-Fog Index (GFI), Coleman-Liau Index, Automated Readability Index, and Simple Measure of Gobbledygook (SMOG) score...
August 16, 2017: Head & Neck
https://www.readbyqxmd.com/read/28809132/impact-of-primary-tracheoesophageal-puncture-on-outcomes-after-total-laryngectomy
#18
Aru Panwar, Oleg Militsakh, Robert Lindau, Andrew Coughlin, Harlan Sayles, Katherine R Rieke, William Lydiatt, Daniel Lydiatt, Russell Smith
Objectives To identify differences in postoperative wound complications associated with a primary tracheoesophageal puncture (TEP) at the time of laryngectomy versus no TEP. Study Design Retrospective review of large national data set. Setting Academic and nonacademic health care facilities in United States, contributing de-identified, risk-adjusted clinical data to the American College of Surgeons National Surgical Quality Improvement Program. Subjects and Methods The National Surgical Quality Improvement Program data set for years 2006 to 2012 identified 430 patients who underwent total laryngectomy with or without a primary TEP...
August 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28807527/does-ct-help-in-predicting-preepiglottic-space-invasion-in-laryngeal-carcinoma
#19
Gülpembe Bozkurt, Özlem Ünsal, İrfan Çelebi, Burak Ayhan, Umman Guliyev, Pınar Akova, Tülay Başak, Berna Uslu Coşkun
OBJECTIVE: Evaluating preepiglottic space involvement in laryngeal cancer by CT may lead misinterpretation. We sought to understand the causes of misinterpretation in evaluating the preepiglottic space by CT and assessed the effects of misinterpretation in treatment plans of patients with laryngeal squamous cell carcinomas. METHODS: Specimen histopathology reports of 102 (99 male, 3 female) patients who underwent total or partial laryngectomy due to supraglottic and/or transglottic laryngeal carcinoma were reviewed...
August 11, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28807066/laser-assisted-management-of-a-symptomatic-anterior-pharyngeal-diverticulum
#20
K Pujary, A C Agarwal, R Balakrishnan, A Bhandarkar
BACKGROUND: Dysphagia is a relatively common symptom following laryngectomy. An anterior pharyngeal diverticulum is a rare cause of post-laryngectomy dysphagia. However, it is often an incidental finding on rigid telescopic examination. METHODS AND RESULTS: This article describes two patients with a symptomatic anterior pharyngeal diverticulum. They were treated by transoral micro-endoscopic potassium titanyl phosphate 532 nm laser assisted resection. Both patients could take feeds orally after the procedure without any difficulty...
August 15, 2017: Journal of Laryngology and Otology
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