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https://www.readbyqxmd.com/read/29456518/environmental-physiology-and-diving-medicine
#1
REVIEW
Gerardo Bosco, Alex Rizzato, Richard E Moon, Enrico M Camporesi
Man's experience and exploration of the underwater environment has been recorded from ancient times and today encompasses large sections of the population for sport enjoyment, recreational and commercial purpose, as well as military strategic goals. Knowledge, respect and maintenance of the underwater world is an essential development for our future and the knowledge acquired over the last few dozen years will change rapidly in the near future with plans to establish secure habitats with specific long-term goals of exploration, maintenance and survival...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29453531/transmucosal-nanoparticles-toxicological-overview
#2
Swapnil Talkar, Sagar Dhoble, Anuradha Majumdar, Vandana Patravale
Nanoparticles have specific physicochemical properties different to bulk materials of the same composition and such properties make them very attractive for commercial and medical applications. Mucoadhesive nanoparticulate dosage forms are designed to enable prolonged retention of these nanoparticles at the site of application, providing a controlled drug release for improved therapeutic outcome. Moreover, drug delivery across the mucosa bypasses the first-pass hepatic metabolism and avoids the degradation by gastrointestinal enzymes...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29452184/production-of-chitinase-from-escherichia-fergusonii-chitosanase-from-chryseobacterium-indologenes-comamonas-koreensis-and-its-application-in-n-acetylglucosamine-production
#3
Tae Il Kim, Dong Hyun Lim, Kwang Soo Baek, Sun Sik Jang, Beom Young Park, Vijayakumar Mayakrishnan
The important platform polysaccharide N-acetylglucosamine (GlcNAc) has great potential to be used in the fields of food, cosmetics, agricultural, pharmaceutical, medicine and biotechnology. This GlcNAc is being produced by traditional methods of environment-unfriendly chemical digestion with strong acids. Therefore, researchers have been paying more attention to enzymatic hydrolysis process for the production of GlcNAc. Hence, in this study, we isolated novel chitinase (Escherichia fergusonii) and chitosanase (Chryseobacterium indologenes, Comamonas koreensis) producing strains from Korean native calves feces, and developed the potential of an eco-friendly microbial progression for GlcNAc production from swollen chitin and chitosan by enzymatic degradation...
February 13, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29447579/double-gene-targeting-pcr-assay-for-the-detection-of-crocodylus-porosus-in-commercial-products
#4
Nina Naquiah, Md Eaqub Ali, M A Motalib Hossain, Sharmin Sultana, Mohammad Nasir Uddin Ahamad
The demand for crocodile meat is quickly growing because of its exotic and organoleptic appeal and also low content of cholesterol and lipids. Moreover, crocodile oil and blood have been used in alternative medicines for treating asthma and several other ailments since ancient times. Furthermore, crocodile hides have great demand in leather industries. All of these have collectively contributed to the extensive hunting, illegal trading and consequent decline of crocodiles in most parts of the world. To keep space with the growing demands, some crocodile species such as Crocodylus porosus have been raised in farms and its commercial trades have been legalized...
February 15, 2018: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/29446222/engineering-controls-in-veterinary-oncology-a-survey-of-148-acvim-board-certified-oncologists-and-environmental-surveillance-in-20-specialty-hospitals
#5
K Alexander, N Northrup, D Clarke, H Lindell, T Laver
Engineering controls (EC, facility and equipment barriers between hazards and people) are used to avoid exposure to chemotherapy drugs. In this study, American College of Veterinary Internal Medicine board-certified veterinary oncologists were surveyed about their use of containment primary EC (C-PEC) and supplemental EC (closed system transfer devices, CSTD). The survey was completed by 148 (38%) of practicing diplomates. All used EC. Both C-PEC and CSTD were used at 92% of hospitals; however, US Pharmacopoeial Convention Chapter <800> (USP <800>) standards were met at only 19% of hospitals and oncologists did not know the type of C-PEC at 18% of hospitals...
February 15, 2018: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/29445390/approaches-and-recent-developments-for-the-commercial-production-of-semi-synthetic-artemisinin
#6
REVIEW
Stephanie H Kung, Sean Lund, Abhishek Murarka, Derek McPhee, Chris J Paddon
The antimalarial drug artemisinin is a natural product produced by the plant Artemisia annua . Extracts of A. annua have been used in Chinese herbal medicine for over two millennia. Following the re-discovery of A. annua extract as an effective antimalarial, and the isolation and structural elucidation of artemisinin as the active agent, it was recommended as the first-line treatment for uncomplicated malaria in combination with another effective antimalarial drug (Artemisinin Combination Therapy) by the World Health Organization (WHO) in 2002...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29437167/dynamic-contrast-enhanced-magnetic-resonance-imaging-for-head-and-neck-cancers
#7
(no author information available yet)
Dynamic myraidpro contrast-enhanced magnetic resonance imaging (DCE-MRI) has been correlated with prognosis in head and neck squamous cell carcinoma as well as with changes in normal tissues. These studies implement different software, either commercial or in-house, and different scan protocols. Thus, the generalizability of the results is not confirmed. To assist in the standardization of quantitative metrics to confirm the generalizability of these previous studies, this data descriptor delineates in detail the DCE-MRI digital imaging and communications in medicine (DICOM) files with DICOM radiation therapy (RT) structure sets and digital reference objects (DROs), as well as, relevant clinical data that encompass a data set that can be used by all software for comparing quantitative metrics...
February 13, 2018: Scientific Data
https://www.readbyqxmd.com/read/29425289/the-numbers-of-2-5-and-6-9-mm-ovarian-follicles-are-inversely-correlated-in-both-normal-women-and-in-polycystic-ovary-syndrome-patients-what-is-the-missing-link
#8
M Peigné, S Catteau-Jonard, G Robin, A Dumont, P Pigny, D Dewailly
STUDY QUESTION: Is the negative correlation between the numbers of 2-5 and 6-9 mm follicles influenced by ovarian and/or metabolic parameter(s) in young control women and in patients with polycystic ovarian syndrome (PCOS)? SUMMARY ANSWER: Our study confirmed that the negative correlation between numbers of follicles sized 2-5 and 6-9 mm was stronger in PCOS than in young control women and was not linked to any ovarian or metabolic parameter. WHAT IS KNOWN ALREADY: Previous reports described a direct negative correlation between the number of small antral follicles (2-5 mm) and large antral follicle (6-9 mm) during the early follicular phase (cycle Days 2-5) in normal and PCOS women...
February 7, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29424826/how-do-patients-respond-to-genetic-testing-for-age-related-macular-degeneration
#9
Catherine A McCarty, Michael J Fuchs, Allan Lamb, Pat Conway
SIGNIFICANCE: The American Academy of Ophthalmology currently recommends against routine genetic testing for complex diseases such as age-related macular degeneration (AMD.) The results of this study demonstrate that patients are very interested in predictive genetic testing for AMD, find the information useful, and make behavioral changes as a result of the information. PURPOSE: The goal of this project was to conduct a pilot AMD genomic medicine study. METHODS: Eligible patients were aged 50 to 65 years with no personal history of AMD...
February 8, 2018: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/29423882/growth-promotion-of-euglena-gracilis-by-ferulic-acid-from-rice-bran
#10
Jiangyu Zhu, Minato Wakisaka
A significant growth promotion of Euglena gracilis was achieved by simply adding ferulic acid from rice bran without diminishing the accumulation of valuable products like paramylon. E. gracilis is a freshwater microalga that is widely applied in cosmetics, food, medicine, and supplements, and it is considered a potential source of biofuel. It is therefore important to enhance its yield at a lower cost for its commercial viability. Introducing a growth regulator derived from agro waste is considered a cheaper and safer strategy to improve biomass productivity compared with other alternatives such as implementing genetic engineering or adding nutrients and plant hormones as growth stimulator...
February 8, 2018: AMB Express
https://www.readbyqxmd.com/read/29423188/availability-of-brands-of-six-essential-medicines-in-124-pharmacies-in-maharashtra
#11
Colin Millard, Abhay B Kadam, Rushikesh Mahajan, Allyson M Pollock, Petra Brhlikova
Background: The aim of this study is to assess the availability and rational use of six essential medicines in private retail outlets in Maharashtra state. The study focuses on the range of brands for each medicine, and the availability of these brands in the pharmacies. The medicines were chosen because they are included in the World Health Organization's (WHO) essential medicines list (EML), the Indian national and Maharashtra state medicines list, and are all included in existing Indian public health initiatives and national disease control programmes...
June 2018: Journal of Global Health
https://www.readbyqxmd.com/read/29422861/the-turkish-medicines-and-medical-devices-agency-comparison-of-its-registration-process-with-australia-canada-saudi-arabia-and-singapore
#12
Emel Mashaki Ceyhan, Hakki Gürsöz, Ali Alkan, Hacer Coşkun, Oğuzhan Koyuncu, Stuart Walker
Introduction: Regulatory agency comparisons can be of more value and facilitate improvements if conducted among countries with common challenges and similar health agency characteristics. A study was conducted to compare the registration review model used by the Turkish Medicines and Medical Devices Agency (Türkiye Ilaç ve Tibbi Cihaz Kurumu; TITCK) with those of four similar-sized regulatory agencies to identify areas of strength and those requiring further improvement within the TITCK in relation to the review process as well as to assess the level of adherence to good review practices (GRevP) in order to facilitate the TITCK progress toward agency goals...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29420456/examining-the-relationship-of-an-all-cause-harm-patient-safety-measure-and-critical-performance-measures-at-the-frontline-of-care
#13
Christine Sammer, Loran D Hauck, Cason Jones, Julie Zaiback-Aldinger, Michael Li, David Classen
BACKGROUND: In 2015, the Institute of Medicine Vital Signs report called for a new patient safety composite measure to lessen the reporting burden of patient harm. Before this report, two patient safety organizations had developed an electronic all-cause harm measurement system leveraging data from the electronic health record, which identified and grouped harms into five broad categories and consolidated them into one all-cause harm outcome measure. OBJECTIVES: The objective of this study was to examine the relationship between this all-cause harm patient safety measure and the following three performance measures important to overall hospital safety performance: safety culture, employee engagement, and patient experience...
February 7, 2018: Journal of Patient Safety
https://www.readbyqxmd.com/read/29420023/palladium-pc-phos-catalyzed-enantioselective-arylation-of-general-sulfenate-anions-scope-and-synthetic-applications
#14
Lei Wang, Mingjie Chen, Peichao Zhang, Wenbo Li, Junliang Zhang
Herein we reported an efficient palladium catalyzed enanti-oselective arylation of both alkyl and aryl sulfenate anions to deliver various chiral sulfoxides in good yields (up to 98%) with excellent enantioselectivities (up to 99% ee) by the use of our developed chiral O, P-ligands (PC-Phos). PC-Phos are easily prepared in short steps from inexpensive commercially available starting materials. The single crystal structure of the PC3/PdCl2 showed that a rarely observed eleven-membered ring was formed via the O, P-coordination with the palladium (II) center...
February 8, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29417475/enterocin-m-and-its-beneficial-effects-in-horses-a-pilot-experiment
#15
Andrea Lauková, Eva Styková, Ivana Kubašová, Soňa Gancarčíková, Iveta Plachá, Dagmar Mudroňová, Anna Kandričáková, Renata Miltko, Grzegorz Belzecki, Igor Valocký, Viola Strompfová
Probiotic bacteria or their antimicrobial proteinaceous substances called bacteriocins (enterocins) hold promising prophylactic potential for animal breeding. This study present the results achieved after application of Enterocin M in horses. Enterocin M has never been applied to horses before. Clinically healthy horses (10) were involved in this pilot experiment. They were placed in the stables of the University of Veterinary Medicine and Pharmacy, Košice, Slovakia, with the approval of the University Ethics Committee...
February 7, 2018: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/29417431/epoetin-biosimilars-in-the-treatment-of-chemotherapy-induced-anemia-10%C3%A2-years-experience-gained
#16
REVIEW
Matti Aapro, Andriy Krendyukov, Martin Schiestl, Pere Gascón
High-quality, safe, and effective biosimilars have the potential to increase access to biological therapies worldwide and to reduce cancer care costs. The European Medicines Agency (EMA) was the first regulatory authority to establish legislative procedures for the approval of biosimilars when they published their guidelines on similar biological medicinal products in 2005. Biosimilar epoetins were first approved in 2007, and a wealth of data has been collected over the last decade. Two biosimilar epoetins (under five commercial names) have been approved by the EMA so far...
February 7, 2018: BioDrugs: Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
https://www.readbyqxmd.com/read/29417233/non-profit-drug-research-and-development-at-a-crossroads
#17
Szymon Jarosławski, Mondher Toumi, Pascal Auquier, Claude Dussart
In wealthy nations, non-profit drug R&D has been proposed to reduce the prices of medicines. We sought to review the ethical and economic issues concerning non-profit drug R&D companies, and the possible impact that their pricing strategy may have on the innovation efforts from for-profit companies targeting the same segment of the pharmaceutical market. There are two possible approaches to pricing drugs developed by non-profit R&D programs: pricing that maximises profits and "affordable" pricing that reflects the cost of manufacturing and distribution, plus a margin that ensures sustainability of the drug supply...
February 7, 2018: Pharmaceutical Research
https://www.readbyqxmd.com/read/29408448/protection-by-dimethyl-fumarate-against-diabetic-cardiomyopathy-in-type-1-diabetic-mice-likely-via-activation-of-nuclear-factor-erythroid-2-related-factor-2
#18
Xinyue Hu, Mohanraj Rajesh, Jian Zhang, Shanshan Zhou, Shudong Wang, Jian Sun, Yi Tan, Yang Zheng, Lu Cai
Oxidative stress and inflammation play key roles in the development of diabetic cardiomyopathy (DCM). Dimethyl fumarate (DMF), an FDA approved medicine for relapsing multiple sclerosis, has manifested its antioxidant and anti-inflammatory function mostly in the central nervous system. In this study, we investigated whether DMF could attenuate the development of DCM. Type 1 diabetes mouse model was established using multiple low-dose streptozotocin, and the diabetic mice were treated with DMF (10 mg/kg body weight) for 3 months...
February 2, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29408180/enhancing-patient-level-clinical-data-access-to-improve-trial-outcomes-promote-evidence-based-practice-and-incentivize-therapeutic-innovation
#19
Alice Fortunato, David W Grainger, Mohamed Abou-El-Enein
Clinical trials are crucial to determining the human safety and efficacy of new therapeutic interventions and innovations. Extraordinary amounts of human experiential data are generated over the course of any clinical drug or therapeutics trial. However, much of these data is never made publicly accessible, either archived openly in accessible formats or venues, published in peer-reviewed journals, or provided to researchers for analysis and scrutiny. Improved, reliable data sharing is essential to inform clinical outcomes and incentivize therapeutic improvements; this need, and the call and concept to improve clinical trial and human therapeutics data accessibility is not new...
January 30, 2018: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29402227/covacs-a-consensus-variant-calling-system
#20
Matteo Chiara, Silvia Gioiosa, Giovanni Chillemi, Mattia D'Antonio, Tiziano Flati, Ernesto Picardi, Federico Zambelli, David Stephen Horner, Graziano Pesole, Tiziana Castrignanò
BACKGROUND: The advent and ongoing development of next generation sequencing technologies (NGS) has led to a rapid increase in the rate of human genome re-sequencing data, paving the way for personalized genomics and precision medicine. The body of genome resequencing data is progressively increasing underlining the need for accurate and time-effective bioinformatics systems for genotyping - a crucial prerequisite for identification of candidate causal mutations in diagnostic screens...
February 5, 2018: BMC Genomics
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