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Commercialism in medicine

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https://www.readbyqxmd.com/read/29045922/the-impact-of-expired-commercial-drugs-on-non-target-marine-species-a-case-study-with-the-use-of-a-battery-of-biomarkers-in-hemocytes-of-mussels
#1
Nektarios Politakis, Alexia Belavgeni, Ioanna Efthimiou, Nikolina Charalampous, Chara Kourkouta, Stefanos Dailianis
The present study investigated the effects of two expired commercial medicines, like Buscopan Plus and Mesulid, commonly classified as household medical wastes, on hemocytes of mussel Mytilus galloprovincialis. Mussel hemocytes' lysosomal membrane stability (in terms of neutral red retention assay), superoxide anions (O2(·)(-)) and nitric oxides (NO, in terms of nitrites) production, lipid peroxidation (in terms of malondialdehyde/MDA content) and the formation of nuclear abnormalities (using the micronucleus/MN assay) were assessed in hemocytes of mussels treated for 7 days with appropriate amounts of each drug (the concentrations of active substances were considered in each case, due to the absence of data related with the excipients) as well as in hemocytes of post-treated/recovered mussels (7 days post-treatment/recovery period)...
October 14, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29044865/quick-identification-of-piperidine-alkaloid-from-roots-of-grewia-nervosa-and-their-glucosidase-inhibitory-activity
#2
Surya N Meena, Mahesh S Majik, Sanjeev C Ghadi, Santosh G Tilve
Grewia nervosa is herbal plant used as traditional medicine for different purposes. Bioassay-guided chemical fractionation of G. nervosa roots resulted in an identification of two known and one new compound, named Microgrewiapine A, Homomicrogrewiapine and N-methyl-microcosamine respectively. Their structures were determined using combination of LC-HRMS, (1) H NMR and IR spectra analyses followed by comparison with those reported in the literature. The problematic separation of these alkaloids on traditional column chromatography (Silica gel, Octadecyl silane (ODS), Sephadex) was resolved by using HPLC method...
October 16, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/29040893/quality-of-online-information-on-breast-cancer-treatment-options
#3
Nadia Arif, Pietro Ghezzi
Offering breast cancer patients treatment choice has become a priority as the involvement of patients in the decision-making process is associated with improved physical and psychological outcomes. As the Internet is increasingly being used by patients as a source of medical information, it is important to evaluate the quality of information relating to breast cancer on the Internet. We analysed 200 websites returned by google.co.uk searching "breast cancer treatment options" in terms of their typology and treatment options described...
October 14, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29040469/the-commercialization-of-traditional-medicine-in-modern-cambodia
#4
Bandeth Ros, Gillian Lê, Barbara McPake, Suzanne Fustukian
Globally, traditional medicine has long been used to address relatively common illness, mental ill health and during childbirth and post-natal care. However, traditional medicine is primarily provided by the private sector and it is unclear how far expenditures on traditional medicine contribute to household impoverishment. A life history method was used to understand the health seeking experience of 24 households over the last 60 years in Cambodia, a country with high out-of-pocket expenditures for health...
October 11, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/29040454/to-fly-as-a-pilot-after-cardiac-surgery
#5
Thomas Syburra, Ed Nicol, Stuart Mitchell, Denis Bron, Ulrich Rosendahl, John Pepper
Aircrew are responsible for safe and reliable aircraft operations. Cardiovascular disease accounts for 50% of all pilot licences declined or withdrawn for medical reasons in Western Europe and is the most common cases of sudden incapacitation in flight. Aircrew retirement age is increasing (up to age 65) in a growing number of airlines and the burden of subclinical, but potentially significant, coronary atherosclerosis is unknown in qualified pilots above age 40. Safety considerations are paramount in aviation medicine, and the most dreaded cardiovascular complications are thromboembolic events and rhythm disturbances due to their potential for sudden incapacitation...
October 13, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29035979/effect-of-a-commercially-available-footwear-insole-on-biomechanical-variables-associated-with-common-running-injuries
#6
Ryan T Lewinson, Darren J Stefanyshyn
OBJECTIVE: To determine whether Dr. Scholl's Active Series (DSAS) footwear insoles alter biomechanical variables associated with running injuries. DESIGN: Randomized, controlled experiment. SETTING: Sport medicine and biomechanics gait analysis laboratory. PARTICIPANTS: Fifteen healthy adults. INTERVENTIONS: The control condition was the participant's own athletic footwear. The experimental condition was the participant's own athletic footwear plus a DSAS insole...
October 10, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/29034240/dark-chocolate-opportunity-for-an-alliance-between-medical-science-and-the-food-industry
#7
Ivan M Petyaev, Yuriy K Bashmakov
Dark chocolate (DC) was originally introduced in human nutrition as a medicinal product consumable in a liquid form. Century-long efforts of food industry transformed this hardly appealing product into a valuable modern culinary delight with clear predominance of confectionery brands of DC on the market. However, current epidemiological data as well as multiple experimental and clinical observations reveal that DC consumption may have a profound effect on cardiovascular, central nervous systems, hemostasis, and lipid metabolism...
2017: Frontiers in Nutrition
https://www.readbyqxmd.com/read/29030303/electrospun-formulations-of-bevacizumab-for-sustained-release-in-the-eye
#8
Ukrit Angkawinitwong, Sahar Awwad, Peng T Khaw, Steve Brocchini, Gareth R Williams
Medicines based on vascular endothelial growth factor (VEGF) neutralising antibodies such as bevacizumab have revolutionized the treatment of age related macular degeneration (AMD), a common blinding disease, and have great potential in preventing scarring after surgery or accelerating the healing of corneal injuries. However, at present, frequent invasive injections are required to deliver these antibodies. Such administration is uncomfortable for patients and expensive for health service providers. Much effort is thus focused on developing dosage forms that can be administered less frequently...
October 10, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29029568/quaternized-chitosan-nanoparticles-loaded-with-the-combined-attenuated-live-vaccine-against-newcastle-disease-and-infectious-bronchitis-elicit-immune-response-in-chicken-after-intranasal-administration
#9
Kai Zhao, Shanshan Li, Wei Li, Lu Yu, Xutong Duan, Jinyu Han, Xiaohua Wang, Zheng Jin
Newcastle disease (ND) and infectious bronchitis (IB) are important diseases, which cause respiratory diseases in chickens, resulting in severely economic losses in the poultry industry. In this study, N-2-hydroxypropyl trimethyl ammonium chloride chitosan (N-2-HACC) and N,O-carboxymethyl chitosan (CMC) were synthesized as adjuvant and delivery carrier for vaccine antigens. N-2-HACC-CMC/NDV/IBV nanoparticles (NPs) (NDV/La Sota and IBV/H120 encapsulated in N-2-HACC-CMC NPs) and N-2-HACC-CMC/NDV-IBV NPs (the mixing of N-2-HACC-CMC/NDV NPs and N-2-HACC-CMC/IBV NPs in a ratio of 1:1) were prepared by the polyelectrolyte composite method, respectively...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/29029316/the-need-for-and-the-role-of-the-toxicological-chemist-in-the-design-of-safer-chemicals
#10
Stephen C DeVito
During the past several decades there has been an ever increasing emphasis for designers of new commercial (non-pharmaceutical) chemicals to include considerations of the potential impacts a planned chemical may have on human health and the environment as part of the design of the chemical, and to design chemicals such that they possess the desired use efficacy while minimizing threats to human health and the environment. Achievement of this goal would be facilitated by the availability of individuals specifically and formally trained to design such chemicals...
September 18, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29029106/iatrogenic-cushing-syndrome-in-a-child-with-congenital-adrenal-hyperplasia-erroneous-compounding-of-hydrocortisone
#11
Julia E Barillas, Daniel Eichner, Ryan Van Wagoner, Phyllis W Speiser
Context: Patients with 21-hydroxylase deficiency congenital adrenal hyperplasia (CAH) require lifelong treatment with glucocorticoids. In growing children the drug of choice is hydrocortisone. Commercially available hydrocortisone tablets do not conform to very low doses prescribed to infants and toddlers, and compounded hydrocortisone is often dispensed to meet therapeutic needs. However, safety, efficacy and uniformity of compounded products are not tested. We report a case of Cushing syndrome in a child with CAH who was inadvertently receiving excessive hydrocortisone in compounded form...
September 28, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29028535/baicalin-and-its-metabolites-suppresses-gluconeogenesis-through-activation-of-ampk-or-akt-in-insulin-resistant-hepg-2-cells
#12
Tao Wang, Hongmei Jiang, Shijie Cao, Qian Chen, Mingyuan Cui, Zhijie Wang, Dandan Li, Jing Zhou, Tao Wang, Feng Qiu, Ning Kang
Scutellaria baicalensis Georgi (S. baicalensis), as a traditional Chinese herbal medicine, is an important component of several famous Chinese medicinal formulas for treating patients with diabetes mellitus. Baicalin (BG), a main bioactive component of S. baicalensis, has been reported to have antidiabetic effects. However, pharmacokinetic studies have indicated that BG has poor oral bioavailability. Therefore, it is hard to explain the pharmacological effects of BG in vivo. Interestingly, several reports show that BG is extensively metabolized in rats and humans...
September 23, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29028368/a-window-into-clinical-next-generation-sequencing-based-oncology-testing-practices
#13
Rakesh Nagarajan, Angela N Bartley, Julia A Bridge, Lawrence J Jennings, Suzanne Kamel-Reid, Annette Kim, Alexander J Lazar, Neal I Lindeman, Joel Moncur, Alex J Rai, Mark J Routbort, Patricia Vasalos, Jason D Merker
CONTEXT: - Detection of acquired variants in cancer is a paradigm of precision medicine, yet little has been reported about clinical laboratory practices across a broad range of laboratories. OBJECTIVE: - To use College of American Pathologists proficiency testing survey results to report on the results from surveys on next-generation sequencing-based oncology testing practices. DESIGN: - College of American Pathologists proficiency testing survey results from more than 250 laboratories currently performing molecular oncology testing were used to determine laboratory trends in next-generation sequencing-based oncology testing...
October 13, 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29027427/-development-and-evaluation-of-a-rapid-pcr-detection-kit-for-ophiocordyceps-sinensis
#14
Fei-Xia Hou, Jing Cao, Sha-Sha Wang, Xi Wang, Yuan Yuan, Cheng Peng, De-Guang Wan, Jin-Lin Guo
Ophiocordyceps sinensis is a valuable traditional Chinese medicine. Due to resource shortage, expensive price and huge market demand, there are many adulterants of O. sinensis in markets. Therefore, it is necessary to establish a rapid and effective method for distinguishing O. sinensis. Based on the species-specific PCR of O. sinensis, this study developed a detection kit by optimizing the components and evaluated the specificity, detection limit, repeatability and shelf life of the kit. The results showed that when the quality of O...
March 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29026646/binary-titanium-alloys-as-dental-implant-materials-a-review
#15
REVIEW
Xiaotian Liu, Shuyang Chen, James K H Tsoi, Jukka Pekka Matinlinna
Titanium (Ti) has been used for long in dentistry and medicine for implant purpose. During the years, not only the commercially pure Ti but also some alloys such as binary and tertiary Ti alloys were used. The aim of this review is to describe and compare the current literature on binary Ti alloys, including Ti-Zr, Ti-In, Ti-Ag, Ti-Cu, Ti-Au, Ti-Pd, Ti-Nb, Ti-Mn, Ti-Mo, Ti-Cr, Ti-Co, Ti-Sn, Ti-Ge and Ti-Ga, in particular to mechanical, chemical and biological parameters related to implant application. Literature was searched using the PubMed and Web of Science databases, as well as google without limiting the year, but with principle key terms such as ' Ti alloy', 'binary Ti ', 'Ti-X' (with X is the alloy element), 'dental implant' and 'medical implant'...
October 2017: Regenerative Biomaterials
https://www.readbyqxmd.com/read/29024555/concise-review-tissue-engineering-of-urinary-bladder-we-still-have-a-long-way-to-go
#16
REVIEW
Jan Adamowicz, Marta Pokrywczynska, Shane Vontelin Van Breda, Tomasz Kloskowski, Tomasz Drewa
Regenerative medicine is a new branch of medicine based on tissue engineering technology. This rapidly developing field of science offers revolutionary treatment strategy aimed at urinary bladder regeneration. Despite many promising announcements of experimental urinary bladder reconstruction, there has been a lack in commercialization of therapies based on current investigations. This is due to numerous obstacles that are slowly being identified and precisely overcome. The goal of this review is to present the current status of research on urinary bladder regeneration and highlight further challenges that need to be gradually addressed...
October 10, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29024519/optimization-of-the-use-of-a-pharmaceutical-grade-xeno-free-medium-for-in-vitro-expansion-of-human-mesenchymal-stem-stromal-cells
#17
M Cimino, R M Gonçalves, E Bauman, M Barroso-Vilares, E Logarinho, C C Barrias, M C L Martins
Human bone marrow (BM)-derived mesenchymal stem/stromal cells (hMSCs) are considered promising therapeutic agents in the field of cell therapy and regenerative medicine, mainly due to their relative facility to be isolated, multi-differentiation potential and immunomodulatory role. However, their application in clinics requires a crucial step of in vitro expansion. Most of the protocols for hMSCs in vitro culture use foetal bovine serum (FBS) as medium supplement that, being from animal origin, presents several safety concerns and may initiate xenogeneic immune responses after cells transplantation...
October 12, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29021919/safeguarding-the-future-of-independent-academic-clinical-cancer-research-in-europe-for-the-benefit-of-patients
#18
Anastassia Negrouk, Denis Lacombe, Fatima Cardoso, Franck Morin, Eva Carrasco, Joan Maurel, Rudolf Maibach, Enrique Aranda, Richard Marais, Rolf A Stahel
Cancer is a complex disease that is constantly evolving. It is now the most common cause of death in Europe after cardiovascular diseases. There are inequalities among European countries, potentially unsustainable healthcare systems impacting quality of cancer care and increasing number of patients with cancer with rare conditions. Clinical and translational research are the backbone in establishing scientific advances as novel treatments and advancing progress to the benefit of patients. Commercially sponsored clinical trials are responsible for developing new medicines that can treat various disease areas, including cancer...
2017: ESMO Open
https://www.readbyqxmd.com/read/29016535/botulinum-toxin-in-aesthetic-medicine-myths-and-realities
#19
Jeffrey S Dover, Gary Monheit, Mark Greener, Andy Pickett
BACKGROUND: Several formulations of Botulinum toxin serotype A (BoNT-A) for aesthetic indications are available, with numbers likely to increase. Preparations are not interchangeable, based on dose unit comparisons. OBJECTIVE: Numerous myths and misconceptions regarding the use of BoNT-A for aesthetic indications have arisen, which this review aims to lay to rest. MATERIALS AND METHODS: This review assesses evidence for and against each of the most common myths regarding BoNT use in aesthetics...
October 6, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28994664/compton-camera-study-for-high-efficiency-spect-and-benchmark-with-anger-system
#20
Mattia Fontana, Denis Dauvergne, Jean Michel Letang, Jean-Luc Ley, Etienne Testa
Single Photon Emission Computed Tomography (SPECT) is at present one of the major techniques for non-invasive diagnostics in nuclear medicine. The clinical routine is mostly based on collimated cameras, originally proposed by Hal Anger. Due to the presence of mechanical collimation, detection eciency and energy acceptance are limited and xed by the system's geometrical features. In order to overcome these limitations, the application of Compton cameras for SPECT has been investigated for several years...
October 10, 2017: Physics in Medicine and Biology
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