keyword
https://read.qxmd.com/read/38473305/a-comparison-of-7-tesla-mr-spectroscopic-imaging-and-3-tesla-mr-fingerprinting-for-tumor-localization-in-glioma-patients
#1
JOURNAL ARTICLE
Philipp Lazen, Pedro Lima Cardoso, Sukrit Sharma, Cornelius Cadrien, Thomas Roetzer-Pejrimovsky, Julia Furtner, Bernhard Strasser, Lukas Hingerl, Alexandra Lipka, Matthias Preusser, Wolfgang Marik, Wolfgang Bogner, Georg Widhalm, Karl Rössler, Siegfried Trattnig, Gilbert Hangel
This paper investigated the correlation between magnetic resonance spectroscopic imaging (MRSI) and magnetic resonance fingerprinting (MRF) in glioma patients by comparing neuro-oncological markers obtained from MRSI to T1/T2 maps from MRF. Data from 12 consenting patients with gliomas were analyzed by defining hotspots for T1, T2, and various metabolic ratios, and comparing them using Sørensen-Dice similarity coefficients (DSCs) and the distances between their centers of intensity (COIDs). The median DSCs between MRF and the tumor segmentation were 0...
February 26, 2024: Cancers
https://read.qxmd.com/read/38471299/simultaneous-analysis-of-cannabinoids-and-terpenes-in-cannabis-sativa-inflorescence-using-full-comprehensive-two-dimensional-liquid-chromatography-coupled-to-smart-active-modulation
#2
JOURNAL ARTICLE
Sebastián J Caruso, Agustín Acquaviva, Julian Lemus Müller, Cecilia B Castells
Nowadays, the higher peak capacity achievable by comprehensive two-dimensional liquid chromatography (LC×LC) for the analysis of vegetal samples is well-recognized. In addition, numerous compounds may be present in very different amounts. Cannabinoids and terpenes represent the main components of Cannabis sativa inflorescence samples, whose quantities are relevant for many application purposes. The analyses of both families are performed by different methods, at least two different separation methodologies, mainly according to their chemical characteristics and concentration levels...
March 11, 2024: Journal of Chromatography. A
https://read.qxmd.com/read/38468047/computational-fractal-based-analysis-of-mr-susceptibility-weighted-imaging-swi-in-neuro-oncology-and-neurotraumatology
#3
JOURNAL ARTICLE
Antonio Di Ieva
Susceptibility-weighted imaging (SWI) is a magnetic resonance imaging (MRI) technique able to depict the magnetic susceptibility produced by different substances, such as deoxyhemoglobin, calcium, and iron. The main application of SWI in clinical neuroimaging is detecting microbleedings and venous vasculature. Quantitative analyses of SWI have been developed over the last few years, aimed to offer new parameters, which could be used as neuroimaging biomarkers. Each technique has shown pros and cons, but no gold standard exists yet...
2024: Advances in Neurobiology
https://read.qxmd.com/read/38441315/gpu-accelerated-bloch-simulations-and-mr-stat-reconstructions-using-the-julia-programming-language
#4
JOURNAL ARTICLE
Oscar van der Heide, Cornelis A T van den Berg, Alessandro Sbrizzi
PURPOSE: MR-STAT is a relatively new multiparametric quantitative MRI technique in which quantitative paramater maps are obtained by solving a large-scale nonlinear optimization problem. Managing reconstruction times is one of the main challenges of MR-STAT. In this work we leverage GPU hardware to reduce MR-STAT reconstruction times. A highly optimized, GPU-compatible Bloch simulation toolbox is developed as part of this work that can be utilized for other quantitative MRI techniques as well...
March 5, 2024: Magnetic Resonance in Medicine
https://read.qxmd.com/read/38428378/the-mendelian-disorders-of-chromatin-machinery-harnessing-metabolic-pathways-and-therapies-for-treatment
#5
REVIEW
Sarah Donoghue, Jordan Wright, Anne K Voss, Paul J Lockhart, David J Amor
The Mendelian disorders of chromatin machinery (MDCMs) represent a distinct subgroup of disorders that present with neurodevelopmental disability. The chromatin machinery regulates gene expression by a range of mechanisms, including by post-translational modification of histones, responding to histone marks, and remodelling nucleosomes. Some of the MDCMs that impact on histone modification may have potential therapeutic interventions. Two potential treatment strategies are to enhance the intracellular pool of metabolites that can act as substrates for histone modifiers and the use of medications that may inhibit or promote the modification of histone residues to influence gene expression...
February 27, 2024: Molecular Genetics and Metabolism
https://read.qxmd.com/read/38428139/isolation-of-serum-derived-placental-amniochorionic-extracellular-vesicles-across-pregnancy-by-immunoaffinity-using-plap-and-hla-g
#6
JOURNAL ARTICLE
Uma Shinde, Aishwarya Rao, Vandana Bansal, Dhanjit Kumar Das, Nafisa Huseni Balasinor, Taruna Madan
Extracellular vesicles (EVs) are membrane-bound nanovesicles secreted from the cells into extracellular space and body fluids. They are considered "fingerprints of parent cells" which can reflect their physiological and functional states. During pregnancy, extracellular vesicles (EVs) are produced by the syncytiotrophoblasts and extravillous trophoblasts and are released into the maternal bloodstream. In the present study, placental alkaline phosphatase (PLAP)-specific extracellular vesicles were isolated from maternal serum-derived EVs (SDE) across pregnancy...
February 1, 2024: Reproduction
https://read.qxmd.com/read/38386904/reconstruction-of-multi-phase-parametric-maps-in-4d-magnetic-resonance-fingerprinting-4d-mrf-by-optimization-of-local-t1-and-t2-sensitivities
#7
JOURNAL ARTICLE
Yat Lam Wong, Tian Li, Chenyang Liu, Ho-Fun Victor Lee, Lai-Yin Andy Cheung, Edward Sai Kam Hui, Peng Cao, Jing Cai
BACKGROUND: Time-resolved magnetic resonance fingerprinting (MRF), or 4D-MRF, has been demonstrated its feasibility in motion management in radiotherapy (RT). However, the prohibitive long acquisition time is one of challenges of the clinical implementation of 4D-MRF. The shortening of acquisition time causes data insufficiency in each respiratory phase, leading to poor accuracies and consistencies of the predicted tissues' properties of each phase. PURPOSE: To develop a technique for the reconstruction of multi-phase parametric maps in four-dimensional magnetic resonance fingerprinting (4D-MRF) through the optimization of local T1 and T2 sensitivities...
February 22, 2024: Medical Physics
https://read.qxmd.com/read/38339327/advances-in-neuro-oncological-imaging-an-update-on-diagnostic-approach-to-brain-tumors
#8
REVIEW
Paniz Sabeghi, Paniz Zarand, Sina Zargham, Batis Golestany, Arya Shariat, Myles Chang, Evan Yang, Priya Rajagopalan, Daniel Chang Phung, Ali Gholamrezanezhad
This study delineates the pivotal role of imaging within the field of neurology, emphasizing its significance in the diagnosis, prognostication, and evaluation of treatment responses for central nervous system (CNS) tumors. A comprehensive understanding of both the capabilities and limitations inherent in emerging imaging technologies is imperative for delivering a heightened level of personalized care to individuals with neuro-oncological conditions. Ongoing research in neuro-oncological imaging endeavors to rectify some limitations of radiological modalities, aiming to augment accuracy and efficacy in the management of brain tumors...
January 30, 2024: Cancers
https://read.qxmd.com/read/38311616/parent-child-couples-display-shared-neural-fingerprints-while-listening-to-stories
#9
JOURNAL ARTICLE
Nir Habouba, Ronen Talmon, Dror Kraus, Rola Farah, Alan Apter, Tamar Steinberg, Rupa Radhakrishnan, Daniel Barazany, Tzipi Horowitz-Kraus
Neural fingerprinting is a method to identify individuals from a group of people. Here, we established a new connectome-based identification model and used diffusion maps to show that biological parent-child couples share functional connectivity patterns while listening to stories. These shared fingerprints enabled the identification of children and their biological parents from a group of parents and children. Functional patterns were evident in both cognitive and sensory brain networks. Defining "typical" shared biological parent-child brain patterns may enable predicting or even preventing impaired parent-child connections that develop due to genetic or environmental causes...
February 4, 2024: Scientific Reports
https://read.qxmd.com/read/38287765/review-of-mr-spectroscopy-analysis-and-artificial-intelligence-applications-for-the-detection-of-cerebral-inflammation-and-neurotoxicity-in-alzheimer-s-disease
#10
JOURNAL ARTICLE
V P Seriramulu, S Suppiah, H H Lee, J H Jang, N F Omar, S N Mohan, N S N Ibrahim, N H M Azmi, I Buhari, U Ahmad
INTRODUCTION: Magnetic resonance spectroscopy (MRS) has an emerging role as a neuroimaging tool for the detection of biomarkers of Alzheimer's disease (AD). To date, MRS has been established as one of the diagnostic tools for various diseases such as breast cancer and fatty liver, as well as brain tumours. However, its utility in neurodegenerative diseases is still in the experimental stages. The potential role of the modality has not been fully explored, as there is diverse information regarding the aberrations in the brain metabolites caused by normal ageing versus neurodegenerative disorders...
January 2024: Medical Journal of Malaysia
https://read.qxmd.com/read/38241108/dual-representation-learning-for-predicting-drug-side-effect-frequency-using-protein-target-information
#11
JOURNAL ARTICLE
Sungjoon Park, Sangseon Lee, Minwoo Pak, Sun Kim
Knowledge of unintended effects of drugs is critical in assessing the risk of treatment and in drug repurposing. Although numerous existing studies predict drug-side effect presence, only four of them predict the frequency of the side effects. Unfortunately, current prediction methods (1) do not utilize drug targets, (2) do not predict well for unseen drugs, and (3) do not use multiple heterogeneous drug features. We propose a novel deep learning-based drug-side effect frequency prediction model. Our model utilized heterogeneous features such as target protein information as well as molecular graph, fingerprints, and chemical similarity to create drug embeddings simultaneously...
January 5, 2024: IEEE Journal of Biomedical and Health Informatics
https://read.qxmd.com/read/38217784/nonuniform-sliding-window-reconstruction-for-accelerated-dual-contrast-agent-quantification-with-mr-fingerprinting
#12
JOURNAL ARTICLE
Anna Marriott, James Rioux, Kimberly Brewer
OBJECTIVE: MR fingerprinting (MRF) can enable preclinical studies of cell tracking by quantifying multiple contrast agents simultaneously, but faster scan times are required for in vivo applications. Sliding window (SW)-MRF is one option for accelerating MRF, but standard implementations are not sufficient to preserve the accuracy of T2 *, which is critical for tracking iron-labelled cells in vivo. PURPOSE: To develop a SW approach to MRF which preserves the T2 * accuracy required for accelerated concentration mapping of iron-labelled cells on single-channel preclinical systems...
January 13, 2024: Magma
https://read.qxmd.com/read/38215808/artificial-intelligence-adjudicated-spatio-temporal-dispersion-a-patient-unique-fingerprint-of-persistent-atrial-fibrillation
#13
JOURNAL ARTICLE
Julien Seitz, Théophile Mohr Durdez, Sabine Lotteau, Clément Bars, André Pisapia, Edouard Gitenay, Jacques Monteau, Mélanie Reist, Meryem Serdi, Amélie Dayot, Michel Bremondy, Mohamed Benadel, Sabrina Siame, Anthony Appetiti, Paola Milpied, Jérôme Kalifa
BACKGROUND: Spatiotemporal dispersion-guided ablation is a tailored approach for patients in persistent atrial fibrillation (AF). The characterization of dispersion extent and distribution and its association with common clinical descriptors of persistent AF (PsAF) patients have not been studied. OBJECTIVES: Artificial intelligence-adjudicated dispersion extent and distribution (AI-DED) was obtained with a machine/deep learning classifier (VX1 software, Volta Medical) in PsAF patients undergoing ablation...
January 10, 2024: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://read.qxmd.com/read/38214038/multimodal-integrated-strategy-for-the-discovery-and-identification-of-antiplatelet-aggregation-q-markers-in-paris-polyphylla-var-yunnanensis
#14
JOURNAL ARTICLE
Yang Li, Rouyuan Wen, Wanqing Yang, Huimei Xu, Qiufeng Xie, Le Wang, Hanzhu Sun, Haizhu Zhang, Conglong Xia
To enhance the quality evaluation and control of traditional Chinese medicine (TCM) and ensure the safety and efficacy of clinical medication, it is imperative to establish a comprehensive quality assessment method aligned with TCM efficacy. This study uses a representative Chinese medicine with multi-origin and multi-efficacy, Paris polyphylla var. yunnanensis (PY), as an illustrative example. Surprisingly, despite the high fingerprint similarity among the 12 batches of PY samples collected from various regions in Yunnan, a notable variation in the composition and content of components was observed...
January 12, 2024: Biomedical Chromatography: BMC
https://read.qxmd.com/read/38196746/high-resolution-myelin-water-fraction-and-quantitative-relaxation-mapping-using-3d-vista-mr-fingerprinting
#15
Congyu Liao, Xiaozhi Cao, Siddharth Srinivasan Iyer, Sophie Schauman, Zihan Zhou, Xiaoqian Yan, Quan Chen, Zhitao Li, Nan Wang, Ting Gong, Zhe Wu, Hongjian He, Jianhui Zhong, Yang Yang, Adam Kerr, Kalanit Grill-Spector, Kawin Setsompop
PURPOSE: This study aims to develop a high-resolution whole-brain multi-parametric quantitative MRI approach for simultaneous mapping of myelin-water fraction (MWF), T1, T2, and proton-density (PD), all within a clinically feasible scan time. METHODS: We developed 3D ViSTa-MRF, which combined Visualization of Short Transverse relaxation time component (ViSTa) technique with MR Fingerprinting (MRF), to achieve high-fidelity whole-brain MWF and T1/T2/PD mapping on a clinical 3T scanner...
December 21, 2023: ArXiv
https://read.qxmd.com/read/38192239/quantifying-3d-mr-fingerprinting-3d-mrf-reproducibility-across-subjects-sessions-and-scanners-automatically-using-mni-atlases
#16
JOURNAL ARTICLE
Andrew Dupuis, Yong Chen, Michael Hansen, Kelvin Chow, Jessie E P Sun, Chaitra Badve, Dan Ma, Mark A Griswold, Rasim Boyacioglu
PURPOSE: Quantitative MRI techniques such as MR fingerprinting (MRF) promise more objective and comparable measurements of tissue properties at the point-of-care than weighted imaging. However, few direct cross-modal comparisons of MRF's repeatability and reproducibility versus weighted acquisitions have been performed. This work proposes a novel fully automated pipeline for quantitatively comparing cross-modal imaging performance in vivo via atlas-based sampling. METHODS: We acquire whole-brain 3D-MRF, turbo spin echo, and MPRAGE sequences three times each on two scanners across 10 subjects, for a total of 60 multimodal datasets...
January 9, 2024: Magnetic Resonance in Medicine
https://read.qxmd.com/read/38186745/digital-analysis-of-the-prostate-tumor-microenvironment-with-high-order-chromogenic-multiplexing
#17
JOURNAL ARTICLE
Rahul Rajendran, Rachel C Beck, Morteza M Waskasi, Brian D Kelly, Daniel R Bauer
As our understanding of the tumor microenvironment grows, the pathology field is increasingly utilizing multianalyte diagnostic assays to understand important characteristics of tumor growth. In clinical settings, brightfield chromogenic assays represent the gold-standard and have developed significant trust as the first-line diagnostic method. However, conventional brightfield tests have been limited to low-order assays that are visually interrogated. We have developed a hybrid method of brightfield chromogenic multiplexing that overcomes these limitations and enables high-order multiplex assays...
December 2024: Journal of Pathology Informatics
https://read.qxmd.com/read/38156945/high-resolution-myelin-water-fraction-and-quantitative-relaxation-mapping-using-3d-vista-mr-fingerprinting
#18
JOURNAL ARTICLE
Congyu Liao, Xiaozhi Cao, Siddharth Srinivasan Iyer, Sophie Schauman, Zihan Zhou, Xiaoqian Yan, Quan Chen, Zhitao Li, Nan Wang, Ting Gong, Zhe Wu, Hongjian He, Jianhui Zhong, Yang Yang, Adam Kerr, Kalanit Grill-Spector, Kawin Setsompop
PURPOSE: This study aims to develop a high-resolution whole-brain multi-parametric quantitative MRI approach for simultaneous mapping of myelin-water fraction (MWF), T1 , T2 , and proton-density (PD), all within a clinically feasible scan time. METHODS: We developed 3D visualization of short transverse relaxation time component (ViSTa)-MRF, which combined ViSTa technique with MR fingerprinting (MRF), to achieve high-fidelity whole-brain MWF and T1 /T2 /PD mapping on a clinical 3T scanner...
December 29, 2023: Magnetic Resonance in Medicine
https://read.qxmd.com/read/38153855/cardiac-mr-fingerprinting-overview-technical-developments-and-applications
#19
REVIEW
Imran Rashid, Gastao Cruz, Nicole Seiberlich, Jesse I Hamilton
Cardiovascular magnetic resonance (CMR) is an established imaging modality with proven utility in assessing cardiovascular diseases. The ability of CMR to characterize myocardial tissue using T1 - and T2 -weighted imaging, parametric mapping, and late gadolinium enhancement has allowed for the non-invasive identification of specific pathologies not previously possible with modalities like echocardiography. However, CMR examinations are lengthy and technically complex, requiring multiple pulse sequences and different anatomical planes to comprehensively assess myocardial structure, function, and tissue composition...
December 28, 2023: Journal of Magnetic Resonance Imaging: JMRI
https://read.qxmd.com/read/38133030/microstructural-characterization-and-magnetic-dielectric-and-transport-properties-of-hydrothermal-la-2-fecro-6-double-perovskites
#20
JOURNAL ARTICLE
Kang Yi, Zhiwei Wu, Qingkai Tang, Jiayuan Gu, Jie Ding, Liangdong Chen, Xinhua Zhu
Double perovskite La2 FeCrO6 (LFCO) powders were synthesized via the hydrothermal method, which crystallized in an orthorhombic ( Pnma ) structure and exhibited a spherical morphology with an average particle size of 900 nm. Fourier transform infrared spectroscopy demonstrated the presence of fingerprints of vibrational modes of [FeO6 ] and [CrO6 ] octahedra in the powders. The XPS spectra revealed dual oxide states of Fe (Fe2+ /Fe3+ ) and Cr (Cr3+ /Cr4+ ) elements, and the oxygen element appeared as lattice oxygen and defect oxygen, respectively...
December 13, 2023: Nanomaterials
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