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https://www.readbyqxmd.com/read/28043909/magnetic-resonance-fingerprinting-based-on-realistic-vasculature-in-mice
#1
Philippe Pouliot, Louis Gagnon, Tina Lam, Pramod K Avti, Chris Bowen, Michèle Desjardins, Ashok K Kakkar, E Thorin, Sava Sakadzic, David A Boas, Frédéric Lesage
Magnetic resonance fingerprinting (MRF) was recently proposed as a novel strategy for MR data acquisition and analysis. A variant of MRF called vascular MRF (vMRF) followed, that extracted maps of three parameters of physiological importance: cerebral oxygen saturation (SatO2), mean vessel radius and cerebral blood volume (CBV). However, this estimation was based on idealized 2-dimensional simulations of vascular networks using random cylinders and the empirical Bloch equations convolved with a diffusion kernel...
December 30, 2016: NeuroImage
https://www.readbyqxmd.com/read/28034994/mr-fingerprinting-of-adult-brain-tumors-initial-experience
#2
C Badve, A Yu, S Dastmalchian, M Rogers, D Ma, Y Jiang, S Margevicius, S Pahwa, Z Lu, M Schluchter, J Sunshine, M Griswold, A Sloan, V Gulani
BACKGROUND AND PURPOSE: MR fingerprinting allows rapid simultaneous quantification of T1 and T2 relaxation times. This study assessed the utility of MR fingerprinting in differentiating common types of adult intra-axial brain tumors. MATERIALS AND METHODS: MR fingerprinting acquisition was performed in 31 patients with untreated intra-axial brain tumors: 17 glioblastomas, 6 World Health Organization grade II lower grade gliomas, and 8 metastases. T1, T2 of the solid tumor, immediate peritumoral white matter, and contralateral white matter were summarized within each ROI...
December 29, 2016: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28019022/use-of-pattern-recognition-for-unaliasing-simultaneously-acquired-slices-in-simultaneous-multislice-mr-fingerprinting
#3
Yun Jiang, Dan Ma, Himanshu Bhat, Huihui Ye, Stephen F Cauley, Lawrence L Wald, Kawin Setsompop, Mark A Griswold
PURPOSE: The purpose of this study is to accelerate an MR fingerprinting (MRF) acquisition by using a simultaneous multislice method. METHODS: A multiband radiofrequency (RF) pulse was designed to excite two slices with different flip angles and phases. The signals of two slices were driven to be as orthogonal as possible. The mixed and undersampled MRF signal was matched to two dictionaries to retrieve T1 and T2 maps of each slice. Quantitative results from the proposed method were validated with the gold-standard spin echo methods in a phantom...
December 26, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28019021/multiparametric-estimation-of-brain-hemodynamics-with-mr-fingerprinting-asl
#4
Pan Su, Deng Mao, Peiying Liu, Yang Li, Marco C Pinho, Babu G Welch, Hanzhang Lu
PURPOSE: Assessment of brain hemodynamics without exogenous contrast agents is of increasing importance in clinical applications. This study aims to develop an MR perfusion technique that can provide noncontrast and multiparametric estimation of hemodynamic markers. METHODS: We devised an arterial spin labeling (ASL) method based on the principle of MR fingerprinting (MRF), referred to as MRF-ASL. By taking advantage of the rich information contained in MRF sequence, up to seven hemodynamic parameters can be estimated concomitantly...
December 26, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28008911/geometrical-vortex-lattice-pinning-and-melting-in-ybacuo-submicron-bridges
#5
G P Papari, A Glatz, F Carillo, D Stornaiuolo, D Massarotti, V Rouco, L Longobardi, F Beltram, V M Vinokur, F Tafuri
Since the discovery of high-temperature superconductors (HTSs), most efforts of researchers have been focused on the fabrication of superconducting devices capable of immobilizing vortices, hence of operating at enhanced temperatures and magnetic fields. Recent findings that geometric restrictions may induce self-arresting hypervortices recovering the dissipation-free state at high fields and temperatures made superconducting strips a mainstream of superconductivity studies. Here we report on the geometrical melting of the vortex lattice in a wide YBCO submicron bridge preceded by magnetoresistance (MR) oscillations fingerprinting the underlying regular vortex structure...
December 23, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27937040/multiparametric-or-practical-quantitative-liver-mri-towards-millisecond-fat-fraction-kilopascal-and-function-era
#6
Emre Unal, Ilkay Sedakat Idilman, Muşturay Karçaaltıncaba
New advances in liver magnetic resonance imaging (MRI) may enable diagnosis of unseen pathologies by conventional techniques. Normal T1 (550-620 ms for 1.5 T and 700-850 ms for 3 T), T2, T2* (>20 ms), T1rho (40-50 ms) mapping, proton density fat fraction (PDFF) (≤5%) and stiffness (2-3kPa) values can enable differentiation of a normal liver from chronic liver and diffuse diseases. Gd-EOB-DTPA can enable assessment of liver function by using postcontrast hepatobiliary phase or T1 reduction rate (normally above 60%)...
February 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27883015/mr-vascular-fingerprinting-in-stroke-and-brain-tumors-models
#7
B Lemasson, N Pannetier, N Coquery, Ligia S B Boisserand, Nora Collomb, N Schuff, M Moseley, G Zaharchuk, E L Barbier, T Christen
In this study, we evaluated an MRI fingerprinting approach (MRvF) designed to provide high-resolution parametric maps of the microvascular architecture (i.e., blood volume fraction, vessel diameter) and function (blood oxygenation) simultaneously. The method was tested in rats (n = 115), divided in 3 models: brain tumors (9 L, C6, F98), permanent stroke, and a control group of healthy animals. We showed that fingerprinting can robustly distinguish between healthy and pathological brain tissues with different behaviors in tumor and stroke models...
November 24, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27851871/robust-sliding-window-reconstruction-for-accelerating-the-acquisition-of-mr-fingerprinting
#8
Xiaozhi Cao, Congyu Liao, Zhixing Wang, Ying Chen, Huihui Ye, Hongjian He, Jianhui Zhong
PURPOSE: To develop a method for accelerated and robust MR fingerprinting (MRF) with improved image reconstruction and parameter matching processes. THEORY AND METHODS: A sliding-window (SW) strategy was applied to MRF, in which signal and dictionary matching was conducted between fingerprints consisting of mixed-contrast image series reconstructed from consecutive data frames segmented by a sliding window, and a precalculated mixed-contrast dictionary. The effectiveness and performance of this new method, dubbed SW-MRF, was evaluated in both phantom and in vivo...
November 7, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27790751/repeatability-of-magnetic-resonance-fingerprinting-t1-and-t2-estimates-assessed-using-the-ismrm-nist-mri-system-phantom
#9
Yun Jiang, Dan Ma, Kathryn E Keenan, Karl F Stupic, Vikas Gulani, Mark A Griswold
PURPOSE: The purpose of this study was to evaluate accuracy and repeatability of T1 and T2 estimates of a MR fingerprinting (MRF) method using the ISMRM/NIST MRI system phantom. METHODS: The ISMRM/NIST MRI system phantom contains multiple compartments with standardized T1 , T2 , and proton density values. Conventional inversion-recovery spin echo and spin echo methods were used to characterize the T1 and T2 values in the phantom. The phantom was scanned using the MRF-FISP method over 34 consecutive days...
October 27, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27757570/mr-imaging-of-brain-pilocytic-astrocytoma-beyond-the-stereotype-of-benign-astrocytoma
#10
Simona Gaudino, Matia Martucci, Rosellina Russo, Emiliano Visconti, Emma Gangemi, Francesco D'Argento, Tommaso Verdolotti, Libero Lauriola, Cesare Colosimo
BACKGROUND: Pilocytic astrocytoma (PA) is the most common pediatric brain glioma and is considered the prototype of benign circumscribed astrocytoma. Despite its low malignancy, the CT and MRI features of brain PA may resemble those of much more aggressive brain tumors. Misdiagnosis of PA is particularly easy when it demonstrates MR morphological and non-morphological findings that are inconsistent with its non-aggressive nature and that overlap with the features of more aggressive brain tumors...
October 18, 2016: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/27666486/agkihpin-a-novel-svtle-from-gloydius-halys-pallas-promotes-platelet-aggregation-in%C3%A2-vitro-and-inhibits-thrombus-formation-in%C3%A2-vivo-in-murine-models-of-thrombosis
#11
Huiqiong Xie, Miao Huang, Qiping Hu, Kejian Sun, Huayu Wu, Wei Shu, Xiaolong Li, Ling Fang
In previous work, a snake venom arginine esterase (SVAE), agkihpin from the venom of Gloydius halys Pallas, was isolated and its biochemical data including Mr, PI, amino acid components and sugar content was collected. Here, the agkihpin was cloned and further characterized and we found that agkihpin could promote ADP-induced platelets aggregation, hydrolyze fibrin, cleave Aα and Bβ chains of fibrinogen and reduce the thrombosis induced by thrombin. Moreover, agkihpin hydrolyzed TAME with optimum temperatures at 30 °C-45 °C, and the hydrolysis was inhibited by EDTA, PMSF, DTT and promoted by Ca(2+), Fe(3+), Mg(2+), Zn(2+)...
November 2016: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/27446810/in-vivo-magnetic-resonance-metabolic-and-morphofunctional-fingerprints-in-experimental-models-of-human-ovarian-cancer
#12
REVIEW
Rossella Canese, Delia Mezzanzanica, Marina Bagnoli, Stefano Indraccolo, Silvana Canevari, Franca Podo, Egidio Iorio
Epithelial ovarian cancer (EOC) is the gynecological malignancy with the highest death rate, characterized by frequent relapse and onset of drug resistance. Disease diagnosis and therapeutic follow-up could benefit from application of molecular imaging approaches, such as magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS), able to monitor metabolic and functional alterations and investigate the underlying molecular mechanisms. Here, we overview the quantitative alterations that occur during either orthotopic or subcutaneous growth of preclinical EOC models...
2016: Frontiers in Oncology
https://www.readbyqxmd.com/read/27079826/pseudo-steady-state-free-precession-for-mr-fingerprinting
#13
Jakob Assländer, Steffen J Glaser, Jürgen Hennig
PURPOSE: This article discusses the signal behavior in the case the flip angle in steady-state free precession sequences is continuously varied as suggested for MR-fingerprinting sequences. Flip angle variations prevent the establishment of a steady state and introduce instabilities regarding to magnetic field inhomogeneities and intravoxel dephasing. We show how a pseudo steady state can be achieved, which restores the spin echo nature of steady-state free precession. METHODS: Based on geometrical considerations, relationships between the flip angle, repetition and echo time are derived that suffice to the establishment of a pseudo steady state...
April 15, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27078862/noddi-and-tensor-based-microstructural-indices-as-predictors-of-functional-connectivity
#14
Fani Deligianni, David W Carmichael, Gary H Zhang, Chris A Clark, Jonathan D Clayden
In Diffusion Weighted MR Imaging (DWI), the signal is affected by the biophysical properties of neuronal cells and their relative placement, as well as extra-cellular tissue compartments. Typically, microstructural indices, such as fractional anisotropy (FA) and mean diffusivity (MD), are based on a tensor model that cannot disentangle the influence of these parameters. Recently, Neurite Orientation Dispersion and Density Imaging (NODDI) has exploited multi-shell acquisition protocols to model the diffusion signal as the contribution of three tissue compartments...
2016: PloS One
https://www.readbyqxmd.com/read/27069871/quantitative-comparisons-on-hand-motor-functional-areas-determined-by-resting-state-and-task-bold-fmri-and-anatomical-mri-for-pre-surgical-planning-of-patients-with-brain-tumors
#15
Bob L Hou, Sanjay Bhatia, Jeffrey S Carpenter
For pre-surgical planning we present quantitative comparison of the location of the hand motor functional area determined by right hand finger tapping BOLD fMRI, resting state BOLD fMRI, and anatomically using high resolution T1 weighted images. Data were obtained on 10 healthy subjects and 25 patients with left sided brain tumors. Our results show that there are important differences in the locations (i.e., > 20 mm) of the determined hand motor voxels by these three MR imaging methods. This can have significant effect on the pre-surgical planning of these patients depending on the modality used...
2016: NeuroImage: Clinical
https://www.readbyqxmd.com/read/27038043/mr-fingerprinting-for-rapid-quantification-of-myocardial-t1-t2-and-proton-spin-density
#16
Jesse I Hamilton, Yun Jiang, Yong Chen, Dan Ma, Wei-Ching Lo, Mark Griswold, Nicole Seiberlich
PURPOSE: To introduce a two-dimensional MR fingerprinting (MRF) technique for quantification of T1 , T2 , and M0 in myocardium. METHODS: An electrocardiograph-triggered MRF method is introduced for mapping myocardial T1 , T2 , and M0 during a single breath-hold in as short as four heartbeats. The pulse sequence uses variable flip angles, repetition times, inversion recovery times, and T2 preparation dephasing times. A dictionary of possible signal evolutions is simulated for each scan that incorporates the subject's unique variations in heart rate...
April 1, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/26924639/mr-fingerprinting-using-the-quick-echo-splitting-nmr-imaging-technique
#17
Yun Jiang, Dan Ma, Renate Jerecic, Jeffrey Duerk, Nicole Seiberlich, Vikas Gulani, Mark A Griswold
PURPOSE: The purpose of the study is to develop a quantitative method for the relaxation properties with a reduced radio frequency (RF) power deposition by combining magnetic resonance fingerprinting (MRF) technique with quick echo splitting NMR imaging technique (QUEST). METHODS: A QUEST-based MRF sequence was implemented to acquire high-order echoes by increasing the gaps between RF pulses. Bloch simulations were used to calculate a dictionary containing the range of physically plausible signal evolutions using a range of T1 and T2 values based on the pulse sequence...
February 28, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/26915119/maximum-likelihood-reconstruction-for-magnetic-resonance-fingerprinting
#18
Bo Zhao, Kawin Setsompop, Huihui Ye, Stephen F Cauley, Lawrence L Wald
This paper introduces a statistical estimation framework for magnetic resonance (MR) fingerprinting, a recently proposed quantitative imaging paradigm. Within this framework, we present a maximum likelihood (ML) formalism to estimate multiple MR tissue parameter maps directly from highly undersampled, noisy k-space data. A novel algorithm, based on variable splitting, the alternating direction method of multipliers, and the variable projection method, is developed to solve the resulting optimization problem...
August 2016: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/26824078/simultaneous-t1-and-t2-brain-relaxometry-in-asymptomatic-volunteers-using-magnetic-resonance-fingerprinting
#19
Chaitra Badve, Alice Yu, Matthew Rogers, Dan Ma, Yiying Liu, Mark Schluchter, Jeffrey Sunshine, Mark Griswold, Vikas Gulani
Magnetic resonance fingerprinting (MRF) is a method of image acquisition that produces multiple MR parametric maps from a single scan. Here, we describe the normal range and progression of MRF-derived relaxometry values with age in healthy individuals. 56 normal volunteers (ages 11-71 years, M:F 24:32) were scanned. Regions of interest were drawn on T1 and T2 maps in 38 areas, including lobar and deep white matter, deep gray nuclei, thalami and posterior fossa structures. Relaxometry differences were assessed using a forward stepwise selection of a baseline model including either gender, age, or both, where variables were included if they contributed significantly (p<0...
December 2015: Tomography: a Journal for Imaging Research
https://www.readbyqxmd.com/read/26794935/mr-fingerprinting-for-rapid-quantitative-abdominal-imaging
#20
Yong Chen, Yun Jiang, Shivani Pahwa, Dan Ma, Lan Lu, Michael D Twieg, Katherine L Wright, Nicole Seiberlich, Mark A Griswold, Vikas Gulani
PURPOSE: To develop a magnetic resonance (MR) "fingerprinting" technique for quantitative abdominal imaging. MATERIALS AND METHODS: This HIPAA-compliant study had institutional review board approval, and informed consent was obtained from all subjects. To achieve accurate quantification in the presence of marked B0 and B1 field inhomogeneities, the MR fingerprinting framework was extended by using a two-dimensional fast imaging with steady-state free precession, or FISP, acquisition and a Bloch-Siegert B1 mapping method...
April 2016: Radiology
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