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https://www.readbyqxmd.com/read/29452979/3-piece-inflatable-penile-prosthesis-placement-following-radical-cystoprostatectomy-and-urinary-diversion-technique-and-outcomes
#1
Jeffrey Loh-Doyle, Mukul B Patil, Hari Sawkar, Kevin Wayne, Stuart D Boyd
BACKGROUND: After radical cystoprostatectomy (RC), postoperative erectile dysfunction (ED) is a common consequence with multiple contributing etiologies. The inflatable penile prosthesis (IPP) offers patients a definitive treatment option when ED is refractory to medical therapies. Because of the hostile postoperative anatomy of these patients, a careful surgical approach is necessary for successful outcomes and to avoid adjacent organ injury. To date, there is no series describing the outcomes of 3-piece IPP placement in patients with urinary diversions...
February 13, 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29452170/expression-and-significance-of-sirt1-in-renal-allografts-at-the-early-stage-of-chronic-renal-allograft-dysfunction
#2
Yue Xia, Jin Deng, Qin Zhou, Xiaofei Shao, Xingyan Yang, Mengjiao Shao, Hequn Zou
OBJECTIVE: To investigate the expression and significance of Sirt1 in renal allografts at the early stage of chronic renal allograft dysfunction (CRAD). METHODS: CRAD rat models were established using classical orthotopic F344-Lewis kidney transplantation. F344 and Lewis uninephrectomized rats were used as controls. Twelve weeks after the operation, the rats were sacrificed for renal function, histological, immunohistochemistry and molecular biological analyses...
February 13, 2018: Transplant Immunology
https://www.readbyqxmd.com/read/29449969/stigma-and-self-management-an-interpretative-phenomenological-analysis-of-the-impact-of-chronic-recurrent-urinary-tract-infections-after-spinal-cord-injury
#3
Jasmine Heath Hearn, Sen Selvarajah, Paul Kennedy, Julian Taylor
Study Design: Qualitative, phenomenological design. Objectives: Neurogenic bladder dysfunction and urinary tract infection (UTI) are common secondary consequences to neurological damage to the spinal cord. This study sought to establish the impact of chronic, recurrent UTIs on people with spinal cord injury (SCI). Setting: Community sample, United Kingdom. Methods: Twelve participants with SCI, aged between 28 and 68 years, who had experienced at least three recurrent UTI events within the previous 12 months were recruited...
2018: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/29449184/relation-of-overactive-bladder-with-motor-symptoms-and-dopamine-transporter-imaging-in-drug-na%C3%A3-ve-parkinson-s-disease
#4
Yasunori Mito, Ichiro Yabe, Hiroaki Yaguchi, Toshiki Takei, Satoshi Terae, Yasutaka Tajima
OBJECTIVES: The aim of the present study was to determine the relation of urinary dysfunction with motor symptoms and nigrostriatal neuron loss in drug-naïve patients with Parkinson's disease (PD). We therefore examined the relation of overactive bladder (OAB) symptoms with motor symptoms and striatal dopamine transporter (DAT) binding measured by [123-Iodine]-fluoropropyl-2beta-carbomethoxy-3beta-(4-iodophenylnortropane) dopamine transporter single-photon emission computed tomography ( 123 I-FP-CIT SPECT)...
February 9, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29441752/bilateral-obstructive-uropathy-caused-by-congenital-bladder-diverticulum-presenting-as-hypertensive-retinopathy
#5
San Kim, Sang Hoo Park, Dong Yoon Kim, Seok Joong Yun, Ok Jun Lee, Heon Seok Han
A congenital bladder diverticulum (CBD) is caused by inherent muscular weakness instead of obstruction of the bladder outlet. The major clinical conditions are recurrent urinary tract infection (UTI) and voiding dysfunction. This report describes a 15-year-old male adolescent who developed sudden visual disturbance resulting from hypertensive retinopathy. The cause of hypertension was bilateral obstructive uropathy caused by enlarged paraureteral bladder diverticula. After the non-functioning right kidney and ureter and the bilateral diverticula were removed, the left ureter was reimplanted in the bladder...
February 19, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29441476/augmented-renal-clearance-in-critically-ill-patients-a-systematic-review
#6
REVIEW
Idoia Bilbao-Meseguer, Alicia Rodríguez-Gascón, Helena Barrasa, Arantxazu Isla, María Ángeles Solinís
BACKGROUND: Traditionally, renal function in critically ill patients has been assessed to identify renal dysfunction, and dose adjustment is generally accepted in such a context. Nevertheless, augmented renal clearance (ARC) is a less well-studied phenomenon that could lead to faster elimination of drugs, resulting in subtherapeutic concentrations and poorer clinical outcomes when standard dosage guidelines are followed. OBJECTIVE: The aim of this systematic review was to gather and summarise all the available evidence on ARC in critically ill patients, including its definition, underlying mechanisms, epidemiology, diagnosis and impact on both drug pharmacokinetics and clinical outcomes...
February 13, 2018: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/29435782/insulin-resistance-in-glycogen-storage-disease-type-ia-linking-carbohydrates-and-mitochondria
#7
Alessandro Rossi, Margherita Ruoppolo, Pietro Formisano, Guglielmo Villani, Lucia Albano, Giovanna Gallo, Daniela Crisci, Augusta Moccia, Giancarlo Parenti, Pietro Strisciuglio, Daniela Melis
BACKGROUND: Glycogen storage disease type I (GSDI) is an inborn error of carbohydrate metabolism caused by mutations of either the G6PC gene (GSDIa) or the SLC37A4 gene (GSDIb). GSDIa patients are at higher risk of developing insulin-resistance (IR). Mitochondrial dysfunction has been implicated in the development of IR. Mitochondrial dysfunction can demonstrate abnormalities in plama acylcarnitines (ACs) and urine organic acids (UOA). The aim of the study was to investigate the presence of mitochondrial impairment in GSDI patients and its possible connection with IR...
February 12, 2018: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/29430679/seeking-certainty-through-narrative-closure-men-s-stories-of-prostate-cancer-treatments-in-a-state-of-liminality
#8
Ilkka Pietilä, Raisa Jurva, Hanna Ojala, Teuvo Tammela
Radical treatments of prostate cancer often lead to a pervasive liminal state that is characterised by multiple uncertainties that relate both to a possible recurrence of cancer and recovery from side effects, such as erectile and urinary dysfunctions. Liminality can make it difficult for cancer patients to narrate their experiences, as their stories lack a definite ending. After interviews with 22 Finnish men who had undergone radical prostatectomy, we analysed how men produce closure in their illness narratives...
February 11, 2018: Sociology of Health & Illness
https://www.readbyqxmd.com/read/29428736/whole-genome-sequencing-identifies-novel-notch3-mutations-for-leukoaraiosis
#9
Wen-Lei Shi, Yong-Biao Zhang, Wei Wei, Hong-Yan Gao, Yong-Hua Huang
BACKGROUND: Leukoaraiosis, a subtype of cerebral small vessel disease, is a common condition found on CT or MRI in elderly people. Leukoaraiosis is strongly associated with cognitive impairment, mental abnormality, gait disorders and urinary dysfunction. However, the genetic risk of leukoaraiosis is largely unknown. OBJECTIVE: The goal of this study is to identify the loss-of-function mutations for leukoaraiosis in Chinese. METHODS: We performed whole-genome sequencing on 11 leukoaraiosis patients and further validated the candidate mutations and tags of the candidate genes in 304 individuals including 160 patients and 144 healthy controls using Sequenom MassARRAY platform...
February 8, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29428473/urinary-dysfunction-after-rectal-cancer-surgery-results-from-a-randomized-trial-comparing-mesorectal-excision-with-and-without-lateral-lymph-node-dissection-for-clinical-stage-ii-or-iii-lower-rectal-cancer-japan-clinical-oncology-group-study-jcog0212
#10
Masaaki Ito, Akihiro Kobayashi, Shin Fujita, Junki Mizusawa, Yukihide Kanemitsu, Yusuke Kinugasa, Koji Komori, Masayuki Ohue, Mitsuyoshi Ota, Yoshihiro Akazai, Manabu Shiozawa, Takashi Yamaguchi, Takayuki Akasu, Yoshihiro Moriya
BACKGROUND: Postoperative urinary dysfunction is a major complication of rectal cancer surgery. A randomized controlled trial (JCOG0212) concluded that the noninferiority of mesorectal excision alone to mesorectal excision with lateral lymph node dissection was not confirmed in terms of relapse-free survival. METHODS: Eligibility criteria included histologically proven clinical stage II/III rectal cancer, a main lesion located in the rectum with the lower margin below the peritoneal reflection, and the absence of lateral lymph node enlargement...
January 17, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29427749/long-term-functional-and-oncological-results-after-sphincter-saving-resection-for-rectal-cancer-cohort-study
#11
Bogdan Badic, Aurélien Joumond, Jérémie Thereaux, Charles Henry Gancel, Jean Pierre Bail
PURPOSE: The treatment of rectal cancer could be complex and the long term complications have the potential to greatly impact the quality of life. The aim of this study was to evaluate the long term functional and oncological results after sphincter-saving resection for rectal cancer. METHODS: Between January 2005 and December 2013, a total of 187 rectal resections with total mesorectal excision (TME) for cancer were performed. The data of 72 (38.5%) patients were available for analysis...
February 7, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29427331/the-role-of-the-mucosa-in-modulation-of-evoked-responses-in-the-spinal-cord-injured-rat-bladder
#12
Claire Doyle, Vivian Cristofaro, Bryan S Sack, Fabliha Mahmood, Maryrose P Sullivan, Rosalyn M Adam
AIMS: Mounting evidence indicates that a variety of factors released from the urothelium or suburothelium can modulate smooth muscle activity. Although the relationship between the mucosa and smooth muscle has been investigated, little is known about the pathophysiologic changes in detrusor-mucosa interactions in neurogenic bladders. The goal of the study was to determine the impact of the mucosa on evoked responses in spinal cord injured (SCI) bladders. METHODS: Urinary bladders were obtained from 6wk SCI rats or age-matched uninjured controls...
February 10, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29427287/determine-the-relationship-between-abdominal-muscle-strength-trunk-control-and-urinary-incontinence-in-children-with-diplegic-cerebral-palsy
#13
Burcu Talu
PURPOSE: The aim of this study is to determine the relationship between abdominal muscle strength, trunk control and urinary incontinence in children with diplegic cerebral palsy. MATERIALS AND METHODS: The current study had a cross-sectional design using analytical study as well as an observational research model. Fifty children between the ages of 5 and 18 years who were diagnosed with diplegic clinical type of cerebral palsy were included in this study using improbable-random sampling method...
February 10, 2018: Urology Journal
https://www.readbyqxmd.com/read/29425362/time-factor-and-disc-herniation-size-are-they-really-predictive-for-outcome-of-urinary-dysfunction-in-patients-with-cauda-equina-syndrome
#14
Radek Kaiser, Luigi Aurelio Nasto, Murali Venkatesan, Petr Waldauf, Belen Perez, Oliver M Stokes, Sleiman Haddad, Hossein Mehdian, Magnum Tsegaye
BACKGROUND: Timing of surgery and the importance of the size of disc prolapse in cauda equina syndrome (CES) remain controversial. OBJECTIVE: To investigate whether there is a relationship between postoperative urinary function, preoperative duration of neurogenic lower urinary tract dysfunction (NLUTD), and the level of canal compromise. METHODS: Seventy-one patients operated for CES were prospectively identified between 2010 and 2013. Fifty-two cases with preoperative NLUTD were included...
February 6, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29424065/trend-and-outcome-of-sepsis-in-children-a-nationwide-cohort-study
#15
Chia-Hung Yo, Tzu-Chun Hsu, Meng-Tse Gabriel Lee, Lorenzo Porta, Po-Yang Tsou, Yu-Hsun Wang, Wan-Chien Lee, Szu-Ta Chen, Chien-Chang Lee
AIM: The aim of this study was to investigate the trend of incidence and outcome of paediatric sepsis in a population-based database. METHODS: Children with sepsis were identified from the 23 million nationwide health insurance claims database of Taiwan. Sepsis was defined by the presence of single ICD-9 code for severe sepsis or septic shock or a combination of ICD-9 codes for infection and organ dysfunction. We analysed the trend of incidence, mortality and source of infection in three age groups: infant (28 days to 1 year), child (1-9 years) and adolescent (10-18 years)...
February 9, 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29417194/-sphincter-and-corpus-cavernosum-prostheses-as-components-of-endoprosthetics-in-urology
#16
T A Ludwig, R Dahlem
Artificial urinary sphincters and penile corpus cavernosum prostheses are effective for patients who are not adequately treated by conservative treatment or pharmacotherapy. Both of these devices show good results concerning functional outcome if used within the correct patient selection. Penile prostheses are meant to be the last line of treatment for severe erectile dysfunction after failure of conventional treatment. Artificial urinary sphincters are the treatment of choice for severe urinary stress incontinence...
February 7, 2018: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/29416500/msa-mimic-rare-occurrence-of-anti-hu-autonomic-failure-and-thymoma-in-a-patient-with-parkinsonism-case-report-and-literature-review
#17
Vito A G Ricigliano, Barbara Fossati, Lorenzo Saraceno, Michele Cavalli, Elena Bazzigaluppi, Giovanni Meola
Thymoma is a tumor originating from thymic gland, frequently manifesting with paraneoplastic neurological disorders. Its association with paraneoplastic dysautonomia is relatively uncommon. Here, we describe the challenging case of a 71 year-old female who developed subacute autonomic failure with digestive pseudo-obstruction, dysphagia, urinary tract dysfunction and orthostatic hypotension complicating an underlying extrapyramidal syndrome that had started 3 months before hospital admission. Autonomic symptoms had 2-month course and acutely worsened just before and during hospitalization...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29416289/multiple-bladder-diverticula-treated-with-robotic-approach-assisted-with-cystoscopy
#18
Diego Antonio Preciado-Estrella, Pascual Cortés-Raygoza, Jorge Gustavo Morales-Montor, Carlos Pacheco-Gahbler
A bladder diverticulum (BD) is a herniation of the bladder urothelium through the muscular bladder wall. As a result, BD presents as a thin walled bag, urine filled connected to bladder lumen through a neck or ostium. The clinical problem with bladder diverticula is their poorly empty during micturition which results in multiple lower urinary tract symptoms as well as recurrent urinary tract infections. Bladder diverticula can be grossly classified in two groups as follows: congenital or acquired with different age presentation and etiological factors in each one...
January 2018: Urology Annals
https://www.readbyqxmd.com/read/29411425/urotherapy-in-children-with-dysfunctional-voiding-and-the-responsiveness-of-two-condition-specific-questionnaires
#19
Toscane C Noordhoff, Lisette A 't Hoen, Joop van den Hoek, Jacintha T C M Verhallen-Dantuma, Marjan J van Ledden-Klok, Bertil F M Blok, Jeroen R Scheepe
AIMS: We sought to establish the responsiveness of the Dutch Vancouver Symptom Score for Dysfunctional Elimination Syndrome (VSSDES) and Pediatric urinary incontinence Quality of life (PinQ) questionnaires. Secondary, we evaluated the outcome of urotherapy extended for children with dysfunctional voiding (DV). METHODS: This cross-sectional multicenter study was done in one tertiary and two community hospitals. Children with DV were included, also when refractory to previous urotherapeutic treatment...
February 7, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29409774/adult-tethered-cord-syndrome-following-chiari-decompression
#20
Christina Jackson, Brian W Yang, Wenya Linda Bi, E Antonio Chiocca, Michael W Groff
BACKGROUND: Adult tethered cord syndrome is a rare neurological disorder that classically presents with back or leg pain, weakness, and urinary dysfunction. Spinal cord tethering has been associated with acquired Chiari malformations. While the effects of tethered cord release on Chiari malformation symptoms have been previously described, we report an unusual case of acquired tethered cord syndrome following Chiari decompression. CASE DESCRIPTION: We report a 68-year-old man with a history of distant T12-level spinal cord injury who presented with two weeks of progressive bilateral lower extremity weakness...
January 31, 2018: World Neurosurgery
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