Xiaoyan Qi, Qiong Liu, Zuxing Wei, Xuyang Hou, Yuhong Jiang, Yin Sun, Shu Xu, Leping Yang, Jun He, Kuijie Liu
The effect of 2,2',4,4'-Tetrabromodiphenyl ether (BDE-47), a persistent environmental pollutant commonly used as a flame retardant in various consumer products, on pancreatitis has not been clearly elucidated, although it has been reported to be toxic to the liver, nervous system, and reproductive system. Acute pancreatitis (AP) and chronic pancreatitis (CP) models were induced in this study by intraperitoneal injection of caerulein. The aim was to investigate the impact of BDE-47 on pancreatitis by exposing the animals to acute (1 week) or chronic (8 weeks) doses of BDE-47 (30 mg/kg in the low-concentration group and 100 mg/kg in the high-concentration group)...
February 24, 2024: Toxicological Sciences: An Official Journal of the Society of Toxicology