keyword
https://read.qxmd.com/read/38408758/synergistic-interaction-between-metal-single-atoms-and-defective-wo-3-x-nanosheets-for-enhanced-sonodynamic-cancer-therapy
#21
JOURNAL ARTICLE
Zhan Zhou, Tao Wang, Tingting Hu, Hao Xu, Lin Cui, Baoli Xue, Xinshuo Zhao, Xiangrong Pan, Shilong Yu, Hai Li, Yong Qin, Jiankang Zhang, Lufang Ma, Ruizheng Liang, Chaoliang Tan
Although metal single-atom (SA)-based nanomaterials have been explored as sonosensitizers for sonodynamic therapy (SDT), they normally exhibit poor activities and need to combine with other therapeutic strategies. Herein, we report the deposition of metal SAs on oxygen vacancy (OV)-rich WO3-x nanosheets to generate synergistic effect for efficient sonodynamic cancer therapy. Crystalline WO3 and OV-rich WO3-x nanosheets are first prepared by a simple calcination of the WO3 ·H2 O nanosheets under an air and N2 atmosphere, respectively...
February 26, 2024: Advanced Materials
https://read.qxmd.com/read/38406602/platelet-membrane-biomimetic-manganese-carbonate-nanoparticles-promote-breast-cancer-stem-cell-clearance-for-sensitized-radiotherapy
#22
JOURNAL ARTICLE
Yi Jiang, Xiaoming Liao, Wei Tang, Chunyu Huang, You Pan, Shipeng Ning
INTRODUCTION: The presence of cancer stem cells (CSCs) significantly limits the therapeutic efficacy of radiotherapy (RT). Efficient elimination of potential CSCs is crucial for enhancing the effectiveness of RT. METHODS: In this study, we developed a biomimetic hybrid nano-system (PMC) composed of MnCO3 as the inner core and platelet membrane (PM) as the outer shell. By exploiting the specific recognition properties of membrane surface proteins, PMC enables precise targeting of CSCs...
2024: International Journal of Nanomedicine
https://read.qxmd.com/read/38403882/recent-advances-in-sonodynamic-therapy-strategies-for-pancreatic-cancer
#23
REVIEW
Peng Cheng, Shuai Ming, Wei Cao, Jixiao Wu, Qiwei Tian, Jing Zhu, Wei Wei
Pancreatic cancer, a prevalent malignancy of the digestive system, has a poor 5-year survival rate of around 10%. Although numerous minimally invasive alternative treatments, including photothermal therapy and photodynamic therapy, have shown effectiveness compared with traditional surgical procedures, radiotherapy, and chemotherapy. However, the application of these alternative treatments is constrained by their depth of penetration, making it challenging to treat pancreatic cancer situated deep within the tissue...
2024: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://read.qxmd.com/read/38398183/the-immunomodulatory-effects-of-fluorescein-mediated-sonodynamic-treatment-lead-to-systemic-and-intratumoral-depletion-of-myeloid-derived-suppressor-cells-in-a-preclinical-malignant-glioma-model
#24
JOURNAL ARTICLE
Serena Pellegatta, Nicoletta Corradino, Manuela Zingarelli, Edoardo Porto, Matteo Gionso, Arianna Berlendis, Gianni Durando, Martina Maffezzini, Silvia Musio, Domenico Aquino, Francesco DiMeco, Francesco Prada
Fluorescein-mediated sonodynamic therapy (FL-SDT) is an extremely promising approach for glioma treatment, resulting from the combination of low-intensity focused ultrasound (FUS) with a sonosensitizer. In the present study, we evaluated the efficacy and immunomodulation of SDT with fluorescein as the sonosensitizer in immunocompetent GL261 glioma mice for the first time. In vitro studies demonstrated that the exposure of GL261 cells to FL-SDT induced immunogenic cell death and relevant upregulation of MHC class I, CD80 and CD86 expression...
February 15, 2024: Cancers
https://read.qxmd.com/read/38398131/theranostic-uses-of-the-heme-pathway-in-neuro-oncology-protoporphyrin-ix-ppix-and-its-journey-from-photodynamic-therapy-pdt-through-photodynamic-diagnosis-pdd-to-sonodynamic-therapy-sdt
#25
REVIEW
Stuart L Marcus, Mark P de Souza
ALA PDT, first approved as a topical therapy to treat precancerous skin lesions in 1999, targets the heme pathway selectively in cancers. When provided with excess ALA, the fluorescent photosensitizer PpIX accumulates primarily in cancer tissue, and ALA PDD is used to identify bladder and brain cancers as a visual aid for surgical resection. ALA PDT has shown promising anecdotal clinical results in recurrent glioblastoma multiforme. ALA SDT represents a noninvasive way to activate ALA PDT and has the potential to achieve clinical success in the treatment of both intracranial and extracranial cancers...
February 10, 2024: Cancers
https://read.qxmd.com/read/38391393/ultrasound-responsive-nanodroplet-based-targeted-therapy-via-conversion-to-microbubbles
#26
JOURNAL ARTICLE
Rajkumar Sahoo, Ankan Kumar Sarkar, Haydar Ali, Nikhil R Jana
Ultrasound-based therapy is appealing as it can be used via a wireless approach at remote parts of the body including the brain. Microbubbles are commonly used in such therapy due to their highly sound-responsive property. However, the larger size of microbubbles limits selective targeting in vitro / in vivo . Here, we report the design of nanodroplets of 70-130 nm in size that can be easily converted to microbubbles via ultrasound exposure. The advantage of this approach is that smaller nanodroplets can be used for cell/subcellular targeting, and next, they can be used for therapy by converting to microbubbles...
February 23, 2024: ACS Applied Bio Materials
https://read.qxmd.com/read/38388555/ultrasound-activated-piezo-hot-carriers-trigger-tandem-catalysis-coordinating-cuproptosis-like-bacterial-death-against-implant-infections
#27
JOURNAL ARTICLE
Yanli Huang, Xufeng Wan, Qiang Su, Chunlin Zhao, Jian Cao, Yan Yue, Shuoyuan Li, Xiaoting Chen, Jie Yin, Yi Deng, Xianzeng Zhang, Tianmin Wu, Zongke Zhou, Duan Wang
Implant-associated infections due to the formation of bacterial biofilms pose a serious threat in medical healthcare, which needs effective therapeutic methods. Here, we propose a multifunctional nanoreactor by spatiotemporal ultrasound-driven tandem catalysis to amplify the efficacy of sonodynamic and chemodynamic therapy. By combining piezoelectric barium titanate with polydopamine and copper, the ultrasound-activated piezo-hot carriers transfer easily to copper by polydopamine. It boosts reactive oxygen species production by piezoelectrics, and facilitates the interconversion between Cu2+ and Cu+ to promote hydroxyl radical generation via Cu+  -catalyzed chemodynamic reactions...
February 22, 2024: Nature Communications
https://read.qxmd.com/read/38382375/high-z-elements-dominated-bismuth-based-heterojunction-nano-semiconductor-for-radiotherapy-enhanced-sonodynamic-breast-cancer-therapy
#28
JOURNAL ARTICLE
Lejin Zhu, Guobo Chen, Qian Wang, Jun Du, Sijia Wu, Jiacheng Lu, Baolin Liu, Yuqing Miao, Yuhao Li
Ultrasound and X-rays possess remarkable tissue penetration capabilities, making them promising candidates for cancer therapy. Sonodynamic therapy, which utilizes ultrasound excitation, offers a safer alternative to radiotherapy and can be combined with X-rays to mitigate the adverse effects on normal tissues. In this study, we developed a bismuth-based heterostructure semiconductor (BFIP) to enhance the efficacy of radiotherapy and sonodynamic therapy in treating breast cancer. The semiconductor is fabricated through a two-step process involving the synthesis of porous spherical bismuth fluoride and partially reduced to bismuth oxyiodide...
February 9, 2024: Journal of Colloid and Interface Science
https://read.qxmd.com/read/38365464/arterial-adventitial-vasa-vasorum-density-reflects-the-progression-of-unstable-plaques-a-retrospective-clinical-study
#29
JOURNAL ARTICLE
Jiemei Yang, Penghao Gao, Qiannan Li, Tengyu Wang, Shuyuan Guo, Jingyu Zhang, Tianyi Zhang, Guodong Wu, Yuanyuan Guo, Zeng Wang, Ye Tian
OBJECTIVE: Arterial adventitial vasa vasorum (AVV) plays an important role in the occurrence and development of atherosclerotic (AS) disease. AS is a systemic disease, and plaque is not only a local vascular event, but also occurs at multiple sites throughout the vascular bed. Currently, effective anti-AVV therapies are lacking. Therefore, we posed the following scientific questions: "does human carotid adventitial vasa vasorum density reflect plaque neovascularization and intimal-media hyperplasia in carotid?"; and "is it possible to reduce human AVV density by sonodynamic therapy (SDT)?" METHODS: A retrospective study was conducted on 160 patients with carotid atherosclerosis...
February 15, 2024: Ultrasound in Medicine & Biology
https://read.qxmd.com/read/38361795/a-novel-cartilage-targeting-mof-hmme-rgd-sonosensitizer-combined-with-sonodynamic-therapy-to-enhance-chondrogenesis-and-cartilage-regeneration
#30
JOURNAL ARTICLE
Shanchao Luo, Yifeng Shang, Zainen Qin, Bo Zhou, Chun Lu, Yangyang Qu, Jinmin Zhao, Ruiming Liang, Li Zheng, Shixing Luo
Articular cartilage regeneration is still a difficult task due to the cartilage's weak capacity for self-healing and the effectiveness of the available therapies. The engineering of cartilage tissue has seen widespread use of stem cell-based therapies. However, efficient orientation of line-specific bone marrow mesenchymal stem cells (BMSCs) to chondrogenesis and maintenance of chondrogenic differentiation challenged stem cell-based therapy. Herein, we developed a Fe-based metal-organic framework (MOF) loaded with hematoporphyrin monomethyl ether (HMME) and cartilage-targeting arginine-aspartate-glycine (RGD) peptide to form MOF-HMME-RGD sonosensitizer to regulate BMSCs chondrogenic differentiation for cartilage regeneration via the modulation of reactive oxygen species (ROS)...
2024: Frontiers in Bioengineering and Biotechnology
https://read.qxmd.com/read/38357599/a-study-of-sonodynamic-therapy-of-melanoma-c540-cells-in-vitro-by-titania-gold-nanoparticles
#31
JOURNAL ARTICLE
Ghazale Perota, Parsa Faghani-Eskandarkolaei, Niloofar Zahraie, Mohammad Hosein Zare, Naghmeh Sattarahmady
BACKGROUND: Sonodynamic Therapy (SDT), a safe and non-invasive strategy in tumor therapy, is in development using novel sono-sensitizers, activated by low-intensity ultrasound radiation. SDT mainly progresses through Reactive Oxygen Species (ROS) generation followed by cell annihilation. OBJECTIVE: The current study aimed to investigate the effect of ultrasound therapy with titania/gold nanoparticles (NPs) on melanoma cancer. MATERIAL AND METHODS: In this experimental study, Titania/gold NPs (TGNPs) were synthesized, and their activity was investigated in sonodynamic therapy of a melanoma cancer cell line (C540)...
February 2024: Journal of Biomedical Physics & Engineering
https://read.qxmd.com/read/38342609/fabrication-of-interface-engineered-s-scheme-heterojunction-nanocatalyst-for-ultrasound-triggered-sustainable-cancer-therapy
#32
JOURNAL ARTICLE
Meng Yuan, Ling Yang, Zhuang Yang, Zhizi Ma, Jie Ma, Zhendong Liu, Ping'an Ma, Ziyong Cheng, Aziz Maleki, Jun Lin
In order to establish a set of perfect heterojunction designs and characterization schemes, step-scheme (S-scheme) BiOBr@Bi2 S3 nanoheterojunctions that enable the charge separation and expand the scope of catalytic reactions, aiming to promote the development and improvement of heterojunction engineering is developed. In this kind of heterojunction system, the Fermi levels mediate the formation of the internal electric field at the interface and guide the recombination of the weak redox carriers, while the strong redox carriers are retained...
February 11, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38334437/tumor-microenvironment-sensitive-ca-2-nanomodulator-combined-with-the-sonodynamic-process-for-enhanced-cancer-therapy
#33
JOURNAL ARTICLE
Hailing Yu, Yongquan Huang, Zeyu Cai, Kaichen Huang, Ting Yu, Huimin Lan, Qianqian Zhang, Lili Wu, Hui Luo
Tumor therapy presents significant challenges, and conventional treatments exhibit limited therapeutic effectiveness. Imbalance of calcium homeostasis as a key cause of tumor cell death has been extensively studied in tumor therapy. Calcium overload therapy has garnered significant interest as a new cancer treatment strategy. This study involves the synthesis of a transformable nanosonosensitizer with a shell of a calcium ion nanomodulator. The nanosystem is designed to induce mitochondrial dysfunction by combining the calcium ion nanomodulator, nanosonosensitizer, and chemotherapeutic drug...
February 9, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38333005/the-application-of-peroxidase-mimetic-nanozymes-in-cancer-diagnosis-and-therapy
#34
REVIEW
Amin Moradi Hasan-Abad, Atefe Shabankare, Amir Atapour, Gholam Ali Hamidi, Mahmoud Salami Zavareh, Ali Sobhani-Nasab
In recent decades, scholarly investigations have predominantly centered on nanomaterials possessing enzyme-like characteristics, commonly referred to as nanozymes. These nanozymes have emerged as viable substitutes for natural enzymes, offering simplicity, stability, and superior performance across various applications. Inorganic nanoparticles have been extensively employed in the emulation of enzymatic activity found in natural systems. Nanoparticles have shown a strong ability to mimic a number of enzyme-like functions...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38330546/ultrasound-technology-assisted-colloidal-nanocrystal-synthesis-and-biomedical-applications
#35
JOURNAL ARTICLE
Haorong Jiao, Qiulian Mao, Noman Razzaq, Rinat Ankri, Jiabin Cui
Non-invasive and high spatiotemporal resolution mythologies for the diagnosis and treatment of disease in clinical medicine promote the development of modern medicine. Ultrasound (US) technology provides a non-invasive, real-time, and cost-effective clinical imaging modality, which plays a significant role in chemical synthesis and clinical translation, especially in in vivo imaging and cancer therapy. On the one hand, the US treatment is usually accompanied by cavitation, leading to high temperature and pressure, so-called "hot spot", playing a significant role in sonochemical-based colloidal synthesis...
February 6, 2024: Ultrasonics Sonochemistry
https://read.qxmd.com/read/38327168/de-novo-designed-ru-ii-metallacycle-as-a-microenvironment-adaptive-sonosensitizer-and-sonocatalyst-for-multidrug-resistant-biofilms-eradication
#36
JOURNAL ARTICLE
Yuling Xu, Yida Pang, Lishi Luo, Amit Sharma, Jingfang Yang, Chonglu Li, Shuang Liu, Jianbo Zhan, Yao Sun
Albeit sonodynamic therapy (SDT) has achieved encouraging progress in microbial sterilization, the scarcity of guidelines for designing highly effective sonosensitizers and the intricate biofilm microenvironment (BME), substantially hamper the therapeutic efficacy against biofilm infections. To address the bottlenecks, we innovatively design a Ru(II) metallacycle-based sonosensitizer/sonocatalyst (named Ru-A3-TTD) to enhance the potency of sonotherapy by employing molecular engineering strategies tailored to BME...
February 7, 2024: Angewandte Chemie
https://read.qxmd.com/read/38325812/time-and-space-dual-blockade-strategy-for-highly-invasive-nature-of-triple-negative-breast-cancer-in-enhanced-sonodynamic-therapy-based-on-fe-mof-nanoplatforms
#37
JOURNAL ARTICLE
Cheng Cao, Yi Lu, Xinni Pan, Yuwan Lin, Shanshan Fan, Jiaqi Niu, Shujing Lin, Haisong Tan, You Wang, Shengsheng Cui, Yanlei Liu
Triple negative breast cancer (TNBC), due to its high malignant degree and strong invasion ability, leads to poor prognosis and easy recurrence, so effectively curbing the invasion of TNBC is the key to obtain ideal therapeutic effect. Herein, we developed a therapeutic strategy that curbed high invasions of TNBC by inhibiting cell physiological activity and disrupting tumor cell structural function to achieve the time and space dual-blockade. The time blockade was caused by the breakthrough of the tumor reducing blockade based on ferroptosis process and the oxidation-toxic free radicals generated by the enhanced sonodynamic therapy (SDT)...
February 7, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38320968/defect-repaired-g-c3n4-nanosheets-elevating-the-efficacy-of-sonodynamic-cancer-therapy-through-enhanced-charge-carrier-migration
#38
JOURNAL ARTICLE
Zhuang Yang, Meng Yuan, Ziyong Cheng, Bin Liu, Zhizi Ma, Jie Ma, Jiashi Zhang, Xinyu Ma, Ping'an Ma, Jun Lin
Sonodynamic therapy (SDT) has garnered growing interest owing to its high tissue penetration depth and minimal side effects. However, the lack of efficient sonosensitizers remains the primary limiting factor for the clinical application of this treatment method. Here, defect-repaired graphene phase carbon nitride (g-C3N4) nanosheets are prepared and utilized for enhanced SDT in anti-tumor treatment. After defect engineering optimization, the bulk defects of g-C3N4 are significantly reduced, resulting in higher crystallinity and exhibiting a polyheptazine imide (PHI) structure...
February 6, 2024: Angewandte Chemie
https://read.qxmd.com/read/38317637/a-cancer-cell-nanotherapy-method-based-on-ghz-film-bulk-acoustic-resonator-and-nanoscale-cao-2
#39
JOURNAL ARTICLE
Zhichao Liu, Yulun Nie, Shuo Wang, Chengliang Sun, Yao Cai, Sheng Liu
Sonodynamic therapy (SDT) is an emerging cancer treatment method in recent years. However, the ultrasound signal utilized for SDT is usually located at a low-frequency spectrum (<2 MHz), and in the field of SDT research, few studies have focused on the exploration and development of ultrasound frequency. Studies have shown that the GHz-level ultrasound can increase cell membrane permeability and have a negligible effect on cell vitality. Herein, we reported the study of a GHz thin film bulk acoustic resonator as an ultrasound source for synergistic treatment with nanoscale calcium peroxide (CaO2 )...
February 6, 2024: Journal of Biomaterials Applications
https://read.qxmd.com/read/38311581/precise-design-of-tio-2-coo-x-heterostructure-via-atomic-layer-deposition-for-synergistic-sono-chemodynamic-oncotherapy
#40
JOURNAL ARTICLE
Wen Liu, Runrun Shao, Lingyun Guo, Jianliang Man, Chengwu Zhang, Lihong Li, Haojiang Wang, Bin Wang, Lixia Guo, Sufang Ma, Bin Zhang, Haipeng Diao, Yong Qin, Lili Yan
Sonodynamic therapy (SDT), a tumor treatment modality with high tissue penetration and low side effects, is able to selectively kill tumor cells by producing cytotoxic reactive oxygen species (ROS) with ultrasound-triggered sonosensitizers. N-type inorganic semiconductor TiO2 has low ROS quantum yields under ultrasound irradiation and inadequate anti-tumor activity. Herein, by using atomic layer deposition (ALD) to create a heterojunction between porous TiO2 and CoOx , the sonodynamic therapy efficiency of TiO2 can be improved...
February 4, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
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