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https://www.readbyqxmd.com/read/29653222/gemcitabine-loaded-microbubbles-for-targeted-chemo-sonodynamic-therapy-of-pancreatic-cancer
#1
Heather Nesbitt, Yingjie Sheng, Sukanta Kamila, Keiran Logan, Keith Thomas, Bridgeen Callan, Mark A Taylor, Mark Love, Declan O'Rourke, Paul Kelly, Estelle Beguin, Eleanor Stride, Anthony P McHale, John F Callan
Pancreatic cancer remains one of the most lethal forms of cancer with a 10-year survival of <1%. With little improvement in survival rates observed in the past 40 years, there is a significant need for new treatments or more effective strategies to deliver existing treatments. The antimetabolite gemcitabine (Gem) is the most widely used form of chemotherapy for pancreatic cancer treatment, but is known to produce significant side effects when administered systemically. We have previously demonstrated the benefit of combined chemo-sonodynamic therapy (SDT), delivered using oxygen carrying microbubbles (O2 MB), as a targeted treatment for pancreatic cancer in a murine model of the disease...
April 10, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29613770/nanoenzyme-augmented-cancer-sonodynamic-therapy-by-catalytic-tumor-oxygenation
#2
Piao Zhu, Yu Chen, Jianlin Shi
Ultrasound (US)-triggered sonodynamic therapy (SDT) can solve the critical issue of low tissue-penetrating depth of traditional phototriggered therapies, but the SDT efficacy is still not satisfactorily high in combating cancer at the current stage. Here we report on augmenting the SDT efficacy based on catalytic nanomedicine, which takes the efficient catalytic features of nanoenzymes to modulate the tumor microenvironment (TME). The multifunctional nanosonosensitizers have been successfully constructed by the integration of a MnOx component with biocompatible/biodegradable hollow mesoporous organosilica nanoparticles, followed by conjugation with protoporphyrin (as the sonosensitizer) and cyclic arginine-glycine-aspartic pentapeptide (as the targeting peptide)...
April 5, 2018: ACS Nano
https://www.readbyqxmd.com/read/29575297/sonodynamic-therapy-assisted-immunotherapy-a-novel-modality-for-cancer-treatment
#3
Qianyu Zhang, Cuixia Bao, Xiaojun Cai, Longwei Jin, Lingling Sun, Yuehong Lang, Libo Li
Sonodynamic therapy (SDT), which is based on photodynamic therapy (PDT), is a new cancer treatment modality. Unlike PDT, which has poor tissue penetration, ultrasound can penetrate deeply into tissues and largely target tumor tissue to mediate the cytotoxicity of sonosensitizers. We hypothesize that, similar to PDT, SDT may perform effectively as a cancer vaccines. Thus, we developed a therapeutic strategy to explore whether SDT can eliminate primary tumors, inhibit metastases, and prevent tumor relapse. In this study, we found that HiPorfin (HPD)-induced SDT killed tumor cells, promoted calreticulin expression on the cell surface and elicited immune responses...
March 25, 2018: Cancer Science
https://www.readbyqxmd.com/read/29555321/blocking-the-glycolytic-pathway-sensitizes-breast-cancer-to-sonodynamic-therapy
#4
Lifen Xie, Xiaolan Feng, Yin Shi, Meng He, Pan Wang, Xiaobing Wang, Zeyuan Mi, Quanhong Liu, Kun Zhang
Inhibition of the increased aerobic glycolysis in cancer cells is a promising methodology for various malignant tumor therapies but is limited by systemic toxicity, at least in part. Recent studies suggest that dual restriction of glycolysis and mitochondrial function may overcome this issue. Sonodynamic therapy (SDT), a prospective therapeutic modality for cancers, has been reported to induce mitochondria-dependent cell damage. Here, we investigated the combined effect of SDT and 2-deoxyglucose (2DG), an anti-glycolytic agent, on breast cancer both in vitro and in vivo...
March 16, 2018: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29493688/two-dimensional-semiconductors-for-ultrasound-mediated-cancer-therapy-the-case-of-black-phosphorus-nanosheets
#5
Jiang Ouyang, Liu Deng, Wansong Chen, Jianping Sheng, Zhenjun Liu, Liqiang Wang, You-Nian Liu
With black phosphorus (BP) as an example, the first two-dimensional (2D) semiconductor based sonosensitizer (Au@BP nanohybrids) was fabricated. Under ultrasound irradiation, Au@BP nanohybrids can generate1 O2 in deep tissues and eradicate tumors with high efficacy. This platform paves the way for the application of 2D semiconductors in sonodynamic cancer therapy.
March 1, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29474964/hypoxia-specific-therapeutic-agents-delivery-nanotheranostics-a-sequential-strategy-for-ultrasound-mediated-on-demand-tritherapies-and-imaging-of-cancer
#6
Qianhua Feng, Yuzhen Li, Xuemei Yang, Wanxia Zhang, Yongwei Hao, Hongling Zhang, Lin Hou, Zhenzhong Zhang
The hypoxic microenvironment induced by sonodynamic therapy (SDT) via sonochemical oxygen consumption usually triggered tumor resistance to SDT, impeding therapeutic efficacy. In this sense, it was highly desired to tackle the hypoxia-related negative issues. Here we provide the therapeutic agents delivery system, TPZ/HMTNPs-SNO, which was constructed by loading tirapazamine (TPZ) into hollow mesoporous titanium dioxide nanoparticles (HMTNPs) with modification of S-nitrosothiol (R-SNO). Upon encountering ultrasound waves, the HMTNPs as sonosensitizers would generate reactive oxygen species (ROS) for SDT...
February 20, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29398130/sonodynamic-therapy-mediated-by-emodin-induces-the-oxidation-of-microtubules-to-facilitate-the-sonodynamic-effect
#7
Jili Qian, Qianping Gao
In previous studies, sonodynamic therapy mediated by emodin (emodin-SDT) induced cytoskeletal filament disruption and apoptosis of THP-1-derived macrophages. In this research, we investigated the underlying mechanism. THP-1-derived macrophages were incubated with emodin and exposed to ultrasound irradiation. After emodin-SDT, we measured the production of reactive oxygen species (ROS) and analyzed the level of amino acid oxidation in microtubules, the cleavage of microtubules and the mitochondrial membrane potential (MMP)...
February 1, 2018: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29365598/protoporphyrin-ix-loaded-microbubbles-mediated-sonodynamic-therapy-reduce-foam-cells-in-the-early-atherosclerosis
#8
Hossein Mehrad, Mehdi Farhoudi, Alberto Foletti
No abstract text is available yet for this article.
August 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29365258/porphyrin-loaded-pluronic-nanobubbles-a-new-us-activated-agent-for-future-theranostic-applications
#9
Federica Bosca, Peter Bielecki, Agata A Exner, Alessandro Barge
Sonodynamic therapy (SDT) has become a promising noninvasive approach for cancer therapy. The treatment exploits the ability of particular molecules (i.e. porphyrins) to be excited by ultrasound and produce reactive oxygen species (ROS) during their decay pro-cess. These reactive species, in turn, result in cell death. To capital-ize on the real-time visualization and on-demand delivery of ultra-sound contrast agents, this study aims to combine porphyrins with nanobubbles (NBs) to obtain an ultrasound-activated theranostic agent that exploits the SDT activity in vitro...
January 24, 2018: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29350596/enhancement-of-antitumor-activity-by-using-5-ala-mediated-sonodynamic-therapy-to-induce-apoptosis-in-malignant-gliomas-significance-of-high-intensity-focused-ultrasound-on-5-ala-sdt-in-a-mouse-glioma-model
#10
Satoshi Suehiro, Takanori Ohnishi, Daisuke Yamashita, Shohei Kohno, Akihiro Inoue, Masahiro Nishikawa, Shiro Ohue, Junya Tanaka, Takeharu Kunieda
OBJECTIVE High invasiveness of malignant gliomas frequently causes early local recurrence of the tumor, resulting in extremely poor outcome. To control such recurrence, novel therapies targeted toward infiltrating glioma cells around the tumor border are required. Here, the authors investigated the antitumor activity of sonodynamic therapy (SDT) combined with a sonosensitizer, 5-aminolevulinic acid (5-ALA), on malignant gliomas to explore the possibility for clinical use of 5-ALA-mediated SDT (5-ALA-SDT). METHODS In vitro cytotoxicity of 5-ALA-SDT was evaluated in U87 and U251 glioma cells and in U251Oct-3/4 glioma stemlike cells...
January 19, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29350186/mri-tracing-non-invasive-tio-2-based-nanoparticles-activated-by-ultrasound-for-multi-mechanism-therapy-of-prostatic-cancer
#11
Pu Yuan, Dongkui Song
To reduce the side effects of chemotherapy and achieve effective and safe therapy for prostate cancer, herein a simple but multi-functional TiO2 :Gd@DOX/FA system activated by ultrasound was developed for the MRI-guided multi-mechanism therapy of prostate cancer. TiO2 nanoparticles served as a sonosensitizer as well as a nanocarrier with the pH-responsive release of DOX. The doping of Gd was not only able to endow the TiO2 with magnetic resonance imaging (MRI) ability, but also further improve the sonodynamic ability of the TiO2 ...
March 23, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29324346/synthesis-and-biological-characterization-of-novel-rose-bengal-derivatives-with-improved-amphiphilicity-for-sono-photodynamic-therapy
#12
Hai-Jun Chen, Xiao-Bin Zhou, Ai-Lan Wang, Bi-Yuan Zheng, Chih-Kuang Yeh, Jian-Dong Huang
Sono-Photodynamic therapy (SPDT) utilizing ultrasound and light has been demonstrated that this novel approach can lower dosage resulting in reduction of the potential side effects caused by sensitizers. Recently, a new formulation of rose bengal (RB) as an intralesional injection has completed clinical trials phase II for PDT treatment of melanoma cancer. However, the inherent unfavorable pharmacological properties of RB hindered its extensive clinical development. With the aim to identify new RB derivatives (RBDs) with enhanced photodynamic and sonodynamic anticancer efficiency, a series of amphiphilic RBDs have been designed, synthesized and biological characterized...
February 10, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29278205/photodynamic-therapy-in-melanoma-where-do-we-stand
#13
Ioana Baldea, Lorin Giurgiu, Ioana Diana Teacoe, Diana Elena Olteanu, Florin Catalin Olteanu, Simona Clichici, Gabriela Adriana Filip
Malignant melanoma is one of the most aggressive malignant tumors with unpredictable evolution. Photodynamic therapy has been successfully used as the first line or palliative therapy for the treatment of lung, esophageal, bladder, non melanoma skin and head and neck cancers. However, classical photodynamic therapy has shown some drawbacks that limit its clinical application in melanoma. The most important challenge is to overcome melanoma resistance, due to melanosomal trapping, presence of melanin, enhanced oxidative stress defense, defects in the apoptotic pathways, immune evasion, neoangiogenesis stimulation...
December 25, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29236476/oxygen-self-produced-nanoplatform-for-relieving-hypoxia-and-breaking-resistance-to-sonodynamic-treatment-of-pancreatic-cancer
#14
Jie Chen, Honglin Luo, Yan Liu, Wei Zhang, Hongxue Li, Tao Luo, Kun Zhang, Yongxiang Zhao, Junjie Liu
Hypoxia as one characteristic hallmark of solid tumors has been demonstrated to be involved in cancer metastasis and progression, induce severe resistance to oxygen-dependent therapies, and hamper the transportation of theranostic agents. To address these issues, an oxygen-self-produced sonodynamic therapy (SDT) nanoplatform involving a modified fluorocarbon (FC)-chain-mediated oxygen delivery protocol has been established to realize highly efficient SDT against hypoxic pancreatic cancer. In this nanoplatform, mesopores and FC chains of FC-chain-functionalized hollow mesoporous organosilica nanoparticle carriers can provide sufficient storage capacity and binding sites for sonosensitizers (IR780) and oxygen, respectively...
December 15, 2017: ACS Nano
https://www.readbyqxmd.com/read/29147483/sonophotodynamic-therapy-mediated-by-liposomal-zinc-phthalocyanine-in-a-colon-carcinoma-tumor-model-role-of-irradiating-arrangement
#15
Maryam Bakhshizadeh, Toktam Moshirian, Habibollah Esmaily, Omid Rajabi, Hooriyeh Nassirli, Ameneh Sazgarnia
Objectives: Low penetration depth of light is the main defect of photodynamic therapy (PDT), which could be improved by sonodynamic therapy (SDT). In this study, a combination of PDT and SDT known as sonophotodynamic therapy (SPDT) was investigated using two reverse arrangements in CT26 tumor model. Materials and Methods: The liposomal zinc phthalocyanine was synthesized and characterized. It was then administered to CT26 tumor models as a sensitizer. The animal models were subjected to PDT, SDT, and the combined treatment in different groups...
October 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29141114/ph-ultrasound-dual-responsive-gas-generator-for-ultrasound-imaging-guided-therapeutic-inertial-cavitation-and-sonodynamic-therapy
#16
Qianhua Feng, Wanxia Zhang, Xuemei Yang, Yuzhen Li, Yongwei Hao, Hongling Zhang, Lin Hou, Zhenzhong Zhang
Herein, a pH/ultrasound dual-responsive gas generator is reported, which is based on mesoporous calcium carbonate (MCC) nanoparticles by loading sonosensitizer (hematoporphyrin monomethyl ether (HMME)) and modifying surface hyaluronic acid (HA). After pinpointing tumor regions with prominent targeting efficiency, HMME/MCC-HA decomposes instantaneously under the cotriggering of tumoral inherent acidic condition and ultrasound (US) irradiation, concurrently accompanying with CO2 generation and HMME release with spatial/temporal resolution...
November 15, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29048439/advancing-porphyrin-s-biomedical-utility-via-supramolecular-chemistry
#17
REVIEW
M A Rajora, J W H Lou, G Zheng
Porphyrins are organic heterocyclic macrocycles with photophysical properties well-suited for clinical phototherapy and cancer imaging. However, their wider application in the clinical management of disease is barred by poor aqueous solubility, bioavailability, tumour accumulation and skin phototoxicity. These limitations instigated the development of supramolecular platforms that improved porphyrin pharmacokinetics and tumour-homing. The supramolecular formulation of porphyrins also facilitates single agent-mediated deeper tissue photoactivation, extended imaging and theranostic multimodality, and synergistic application of multiple therapies...
October 30, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/28891984/in-vitro-sonodynamic-therapeutic-effect-of-polyion-complex-micelles-incorporating-titanium-dioxide-nanoparticles
#18
Satoshi Yamamoto, Masafumi Ono, Eiji Yuba, Atsushi Harada
Titanium dioxide nanoparticles (TiO₂ NPs) can act as sonosensitizers, generating reactive oxygen species under ultrasound irradiation, for use in sonodynamic therapy. For TiO₂ NPs delivery, we prepared polyion complex micelles incorporating TiO₂ NPs (TiO₂ NPs-PIC micelles) by mixing TiO₂ NPs with polyallylamine bearing poly(ethylene glycol) grafts. In this study, the effects of polymer composition and ultrasound irradiation conditions on the sonodynamic therapeutic effect toward HeLa cells were evaluated experimentally using cell viability evaluation, intracellular distribution observation, and a cell staining assay...
September 11, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28843620/the-combination-of-glycolytic-inhibitor-2-deoxyglucose-and-microbubbles-increases-the-effect-of-5-aminolevulinic-acid-sonodynamic-therapy-in-liver-cancer-cells
#19
Rui Xie, Tongying Xu, Jiuxin Zhu, Xiaoli Wei, Wenting Zhu, Longmin Li, Yufeng Wang, Yu Han, Jianhua Zhou, Yuxian Bai
Sonodynamic therapy (SDT) overcomes the shortcoming of photodynamic therapy in the treatment of cancer. Previous studies indicated that the glycolysis inhibitor 2-deoxyglucose (2-DG) potentiated photodynamic therapy induced tumor cell death and microbubbles (MBs) improved the SDT performance. We hypothesized that the combination of 2-DG and MBs will increase the effect of 5-aminolevulinic acid (ALA)-SDT in HepG2 liver cancer cells. When cells were treated with 5-min ALA-SDT and 2-mmol/L 2-DG, the cell survival rate decreased to 73...
August 23, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28829584/two-dimensional-graphene-augments-nanosonosensitized-sonocatalytic-tumor-eradication
#20
Chen Dai, Shengjian Zhang, Zhuang Liu, Rong Wu, Yu Chen
Ultrasound (US) can activate sonosensitizers for sonodynamic therapy (SDT), but the low activation efficiency and therapeutic outcome significantly hinder its further clinical translation. Inspired by the principles of semiconductor physics and photocatalysis chemistry, we herein report on augmenting the sonocatalytic efficiency of semiconductor TiO2-based nanosonosensitizers for highly efficient SDT by the integration of two-dimensional (2D) ultrathin graphene with TiO2 nanosonosensitizers. The high electroconductivity of graphene facilitates the separation of the electron (e(-)) and hole (h(+)) pairs from the energy band of TiO2 and avoids their recombination upon external US irradiation; thus it significantly augments the therapeutic efficiency of TiO2 nanosonosensitizers for SDT against tumors...
September 26, 2017: ACS Nano
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