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https://www.readbyqxmd.com/read/29878150/rapid-inhibition-of-atherosclerotic-plaque-progression-by-sonodynamic-therapy
#1
Xin Sun, Shuyuan Guo, Jianting Yao, Huan Wang, Chenghai Peng, Bicheng Li, Yu Wang, Yongxing Jiang, Tengyu Wang, Yang Yang, Jiali Cheng, Wei Wang, Zhengyu Cao, Xuezhu Zhao, Xiang Li, Jing Sun, Jiemei Yang, Fang Tian, Xi Chen, Qiannan Li, Weiwei Gao, Jing Shen, Qi Zhou, Peng Wang, Zhitao Li, Zhen Tian, Zhiguo Zhang, Wenwu Cao, Min Li, Ye Tian
Aims: Currently, efficient regimens to reverse atherosclerotic plaques are not available in the clinic. Here, we present sonodynamic therapy (SDT) as a novel methodology to rapidly inhibit progression of atherosclerotic plaques. Methods and Results: In atherosclerotic rabbit and apoE-deficient mouse models, SDT efficiently decreased the atherosclerotic burden within one week, revealing a decrease in the size of the atherosclerotic plaque and enlarged lumen. The shrunken atherosclerotic plaques displayed compositional alterations, with a reduction in lesional macrophages and lipids...
June 6, 2018: Cardiovascular Research
https://www.readbyqxmd.com/read/29763901/5-aminolevulinic-acid-mediated-sonodynamic-therapy-alleviates-atherosclerosis-via-enhancing-efferocytosis-and-facilitating-a-shift-in-the-th1-th2-balance-toward-th2-polarization
#2
Yang Yang, Yuanyuan Liu, Xi Chen, Jie Gong, Zhen Huang, Wei Wang, Yuanqi Shi, Yu Wang, Jianting Yao, Zhaoqian Shen, Zhen Tian, Hong Jin, Ye Tian
BACKGROUND/AIMS: We and other groups have demonstrated that 5-aminolevulinic acid (ALA)-mediated sonodynamic therapy (ALA-SDT) induces macrophage and foam cell apoptosis and stabilizes atherosclerosis (AS) plaques in animal models. Lymphocytes also play vital roles in the development of AS. The primary purpose of the present study was to investigate the effects of ALA-SDT on T helper (Th) cell fate and function, Th subset differentiation, and atherosclerotic lesion stability. METHODS: We utilized ALA-SDT on Western diet-fed apoE-/-mice in vivo and human Jurkat cells in vitro...
May 9, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29746502/potential-involvement-of-the-18-kda-translocator-protein-and-reactive-oxygen-species-in-apoptosis-of-thp-1-macrophages-induced-by-sonodynamic-therapy
#3
Xin Sun, Shuyuan Guo, Wei Wang, Zhengyu Cao, Juhua Dan, Jiali Cheng, Wei Cao, Fang Tian, Wenwu Cao, Ye Tian
Sonodynamic therapy (SDT) with exogenous protoporphyrin IX (PpIX) or endogenous PpIX derived from 5-aminolevulinic acid (ALA) has been carried out to produce apoptotic effects on macrophages, indicating a potential treatment methodology for atherosclerosis. Our previous studies have found that mitochondria damage by reactive oxygen species (ROS) plays a major role in the SDT-induced apoptosis. This study aimed at investigating the potential involvement of the mitochondrial 18 kDa translocator protein (TSPO) and ROS in the pro-apoptotic effects of SDT on THP-1 macrophages...
2018: PloS One
https://www.readbyqxmd.com/read/29738830/insight-into-ultrasound-mediated-reactive-oxygen-species-generation-by-various-metal-porphyrin-complexes
#4
Francesca Giuntini, Federica Foglietta, Arianna M Marucco, Adriano Troia, Nikolai V Dezhkunov, Alessandro Pozzoli, Gianni Durando, Ivana Fenoglio, Loredana Serpe, Roberto Canaparo
Ultrasound is used to trigger the cytotoxicity of chemical compounds, known as sonosensitisers, in an approach called sonodynamic therapy (SDT), which is under investigation herein. The generation of reactive oxygen species (ROS) has been proposed as the main biological occurrence that leads to the cytotoxic effects, which are achieved via the synergistic action of two components: the energy-absorbing sonosensitiser and ultrasound (US), which are both harmless per se. Despite some promising results, a lack of investigation into the mechanisms behind US sonosensitiser-mediated ROS generation has prevented SDT from reaching its full potential...
May 5, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29697960/oxygen-deficient-black-titania-for-synergistic-enhanced-sonodynamic-and-photoinduced-cancer-therapy-at-near-infrared-ii-biowindow
#5
Xiaoxia Han, Ju Huang, Xiangxiang Jing, Dayan Yang, Han Lin, Zhigang Wang, Pan Li, Yu Chen
The conventional inorganic semiconductors are not suitable for in vivo therapeutic nanomedicine because of the lack of an adequate and safe irradiation source to activate them. This work reports on the rational design of titania (TiO2 )-based semiconductors for enhanced and synergistic sono-/photoinduced tumor eradication by creating an oxygen-deficient TiO2- x layer onto the surface of TiO2 nanocrystals, which can create a crystalline-disordered core/shell structure (TiO2 @TiO2- x ) with black color. As found in the lessons from traditional photocatalysis, such an oxygen-deficient TiO2- x layer with abundant oxygen defects facilitates and enhances the separation of electrons (e- ) and holes (h+ ) from the energy-band structure upon external ultrasound irradiation, which can significantly improve the efficacy of sono-triggered sonocatalytic tumor therapy...
May 22, 2018: ACS Nano
https://www.readbyqxmd.com/read/29672956/metal-organic-framework-derived-carbon-nanostructure-augmented-sonodynamic-cancer-therapy
#6
Xueting Pan, Lixin Bai, Hui Wang, Qingyuan Wu, Hongyu Wang, Shuang Liu, Bolong Xu, Xinghua Shi, Huiyu Liu
Sonodynamic therapy (SDT) can overcome the critical issue of depth-penetration barrier of photo-triggered therapeutic modalities. However, the discovery of sonosensitizers with high sonosensitization efficacy and good stability is still a significant challenge. In this study, the great potential of a metal-organic-framework (MOF)-derived carbon nanostructure that contains porphyrin-like metal centers (PMCS) to act as an excellent sonosensitizer is identified. Excitingly, the superior sonosensitization effect of PMCS is believed to be closely linked to the porphyrin-like macrocycle in MOF-derived nanostructure in comparison to amorphous carbon nanospheres, due to their large highest occupied molecular orbital (HOMO)-lowest unoccupied molecular orbital (LUMO) gap for high reactive oxygen species (ROS) production...
June 2018: Advanced Materials
https://www.readbyqxmd.com/read/29671631/antimicrobial-sonodynamic-and-photodynamic-therapies-against-candida-albicans
#7
Fernanda Alves, Ana Cláudia Pavarina, Ewerton Garcia de Oliveira Mima, Anthony P McHale, John Francis Callan
Candida albicans biofilms exhibit unique characteristics and are highly resistant to antifungal agents. Antimicrobial photodynamic therapy (aPDT) is an alternative treatment limited to treating superficial infections due to the poor light penetration. In this manuscript, the antifungal properties of sonodynamic therapy (SDT) were assessed. SDT uses ultrasound instead of light, enabling the treatment of deeper infections. Planktonic cells and biofilms of C. albicans were treated with aPDT or SDT, in addition to combined aPDT/SDT, with cell survival determined using colony forming units...
April 2018: Biofouling
https://www.readbyqxmd.com/read/29666990/sonodynamic-therapy-sdt-a-novel-strategy-for-cancer-nanotheranostics
#8
REVIEW
Xueting Pan, Hongyu Wang, Shunhao Wang, Xiao Sun, Lingjuan Wang, Weiwei Wang, Heyun Shen, Huiyu Liu
Sonodynamic therapy (SDT) is a promising non-invasive therapeutic modality. Compared to photo-inspired therapy, SDT provides many opportunities and benefits, including deeper tissue penetration, high precision, less side effects, and good patient compliance. Thanks to the facile engineerable nature of nanotechnology, nanoparticles-based sonosensitizers exhibit predominant advantages, such as increased SDT efficacy, binding avidity, and targeting specificity. This review aims to summarize the possible mechanisms of SDT, which can be expected to provide the theoretical basis for SDT development in the future...
April 2018: Science China. Life Sciences
https://www.readbyqxmd.com/read/29653222/gemcitabine-loaded-microbubbles-for-targeted-chemo-sonodynamic-therapy-of-pancreatic-cancer
#9
Heather Nesbitt, Yingjie Sheng, Sukanta Kamila, Keiran Logan, Keith Thomas, Bridgeen Callan, Mark A Taylor, Mark Love, Declan O'Rourke, Paul Kelly, Estelle Beguin, Eleanor Stride, Anthony P McHale, John F Callan
Pancreatic cancer remains one of the most lethal forms of cancer with a 10-year survival of <1%. With little improvement in survival rates observed in the past 40 years, there is a significant need for new treatments or more effective strategies to deliver existing treatments. The antimetabolite gemcitabine (Gem) is the most widely used form of chemotherapy for pancreatic cancer treatment, but is known to produce significant side effects when administered systemically. We have previously demonstrated the benefit of combined chemo-sonodynamic therapy (SDT), delivered using oxygen carrying microbubbles (O2 MB), as a targeted treatment for pancreatic cancer in a murine model of the disease...
June 10, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29613770/nanoenzyme-augmented-cancer-sonodynamic-therapy-by-catalytic-tumor-oxygenation
#10
Piao Zhu, Yu Chen, Jianlin Shi
Ultrasound (US)-triggered sonodynamic therapy (SDT) can solve the critical issue of low tissue-penetrating depth of traditional phototriggered therapies, but the SDT efficacy is still not satisfactorily high in combating cancer at the current stage. Here we report on augmenting the SDT efficacy based on catalytic nanomedicine, which takes the efficient catalytic features of nanoenzymes to modulate the tumor microenvironment (TME). The multifunctional nanosonosensitizers have been successfully constructed by the integration of a MnO x component with biocompatible/biodegradable hollow mesoporous organosilica nanoparticles, followed by conjugation with protoporphyrin (as the sonosensitizer) and cyclic arginine-glycine-aspartic pentapeptide (as the targeting peptide)...
April 24, 2018: ACS Nano
https://www.readbyqxmd.com/read/29575297/sonodynamic-therapy-assisted-immunotherapy-a-novel-modality-for-cancer-treatment
#11
Qianyu Zhang, Cuixia Bao, Xiaojun Cai, Longwei Jin, Lingling Sun, Yuehong Lang, Libo Li
Sonodynamic therapy (SDT), which is based on photodynamic therapy (PDT), is a new cancer treatment modality. Unlike PDT, which has poor tissue penetration, ultrasound can penetrate deeply into tissues and largely target tumor tissue to mediate the cytotoxicity of sonosensitizers. We hypothesize that, similar to PDT, SDT may perform effectively as a cancer vaccine. Thus, we developed a therapeutic strategy to explore whether SDT can eliminate primary tumors, inhibit metastases, and prevent tumor relapse. In the present study, we found that HiPorfin (HPD)-induced SDT killed tumor cells, promoted calreticulin expression on the cell surface and elicited immune responses...
March 25, 2018: Cancer Science
https://www.readbyqxmd.com/read/29555321/blocking-the-glycolytic-pathway-sensitizes-breast-cancer-to-sonodynamic-therapy
#12
Lifen Xie, Xiaolan Feng, Yin Shi, Meng He, Pan Wang, Xiaobing Wang, Zeyuan Mi, Quanhong Liu, Kun Zhang
Inhibition of the increased aerobic glycolysis in cancer cells is a promising methodology for various malignant tumor therapies but is limited by systemic toxicity, at least in part. Recent studies suggest that dual restriction of glycolysis and mitochondrial function may overcome this issue. Sonodynamic therapy (SDT), a prospective therapeutic modality for cancers, has been reported to induce mitochondria-dependent cell damage. Here, we investigated the combined effect of SDT and 2-deoxyglucose (2DG), an anti-glycolytic agent, on breast cancer both in vitro and in vivo...
June 2018: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29493688/two-dimensional-semiconductors-for-ultrasound-mediated-cancer-therapy-the-case-of-black-phosphorus-nanosheets
#13
Jiang Ouyang, Liu Deng, Wansong Chen, Jianping Sheng, Zhenjun Liu, Liqiang Wang, You-Nian Liu
With black phosphorus (BP) as an example, the first two-dimensional (2D) semiconductor based sonosensitizer (Au@BP nanohybrids) was fabricated. Under ultrasound irradiation, Au@BP nanohybrids can generate 1 O2 in deep tissues and eradicate tumors with high efficacy. This platform paves the way for the application of 2D semiconductors in sonodynamic cancer therapy.
March 15, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29474964/hypoxia-specific-therapeutic-agents-delivery-nanotheranostics-a-sequential-strategy-for-ultrasound-mediated-on-demand-tritherapies-and-imaging-of-cancer
#14
Qianhua Feng, Yuzhen Li, Xuemei Yang, Wanxia Zhang, Yongwei Hao, Hongling Zhang, Lin Hou, Zhenzhong Zhang
The hypoxic microenvironment induced by sonodynamic therapy (SDT) via sonochemical oxygen consumption usually triggered tumor resistance to SDT, impeding therapeutic efficacy. In this sense, it was highly desired to tackle the hypoxia-related negative issues. Here we provide the therapeutic agents delivery system, TPZ/HMTNPs-SNO, which was constructed by loading tirapazamine (TPZ) into hollow mesoporous titanium dioxide nanoparticles (HMTNPs) with modification of S-nitrosothiol (R-SNO). Upon encountering ultrasound waves, the HMTNPs as sonosensitizers would generate reactive oxygen species (ROS) for SDT...
April 10, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29398130/sonodynamic-therapy-mediated-by-emodin-induces-the-oxidation-of-microtubules-to-facilitate-the-sonodynamic-effect
#15
Jili Qian, Qianping Gao
In previous studies, sonodynamic therapy mediated by emodin (emodin-SDT) induced cytoskeletal filament disruption and apoptosis of THP-1-derived macrophages. In this research, we investigated the underlying mechanism. THP-1-derived macrophages were incubated with emodin and exposed to ultrasound irradiation. After emodin-SDT, we measured the production of reactive oxygen species (ROS) and analyzed the level of amino acid oxidation in microtubules, the cleavage of microtubules and the mitochondrial membrane potential (MMP)...
April 2018: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29365598/protoporphyrin-ix-loaded-microbubbles-mediated-sonodynamic-therapy-reduce-foam-cells-in-the-early-atherosclerosis
#16
Hossein Mehrad, Mehdi Farhoudi, Alberto Foletti
No abstract text is available yet for this article.
August 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29365258/porphyrin-loaded-pluronic-nanobubbles-a-new-us-activated-agent-for-future-theranostic-applications
#17
Federica Bosca, Peter A Bielecki, Agata A Exner, Alessandro Barge
Sonodynamic therapy (SDT) has become a promising noninvasive approach for cancer therapy. The treatment exploits the ability of particular molecules (i.e., porphyrins) to be excited by ultrasound and produce reactive oxygen species (ROS) during their decay process. These reactive species, in turn, result in cell death. To capitalize on the real-time visualization and on-demand delivery of ultrasound contrast agents, this study aims to combine porphyrins with nanobubbles (NBs) to obtain an ultrasound-activated theranostic agent that exploits the SDT activity in vitro...
February 21, 2018: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29350596/enhancement-of-antitumor-activity-by-using-5-ala-mediated-sonodynamic-therapy-to-induce-apoptosis-in-malignant-gliomas-significance-of-high-intensity-focused-ultrasound-on-5-ala-sdt-in-a-mouse-glioma-model
#18
Satoshi Suehiro, Takanori Ohnishi, Daisuke Yamashita, Shohei Kohno, Akihiro Inoue, Masahiro Nishikawa, Shiro Ohue, Junya Tanaka, Takeharu Kunieda
OBJECTIVE High invasiveness of malignant gliomas frequently causes early local recurrence of the tumor, resulting in extremely poor outcome. To control such recurrence, novel therapies targeted toward infiltrating glioma cells around the tumor border are required. Here, the authors investigated the antitumor activity of sonodynamic therapy (SDT) combined with a sonosensitizer, 5-aminolevulinic acid (5-ALA), on malignant gliomas to explore the possibility for clinical use of 5-ALA-mediated SDT (5-ALA-SDT). METHODS In vitro cytotoxicity of 5-ALA-SDT was evaluated in U87 and U251 glioma cells and in U251Oct-3/4 glioma stemlike cells...
January 19, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29350186/mri-tracing-non-invasive-tio-2-based-nanoparticles-activated-by-ultrasound-for-multi-mechanism-therapy-of-prostatic-cancer
#19
Pu Yuan, Dongkui Song
To reduce the side effects of chemotherapy and achieve effective and safe therapy for prostate cancer, herein a simple but multi-functional TiO2 :Gd@DOX/FA system activated by ultrasound was developed for the MRI-guided multi-mechanism therapy of prostate cancer. TiO2 nanoparticles served as a sonosensitizer as well as a nanocarrier with the pH-responsive release of DOX. The doping of Gd was not only able to endow the TiO2 with magnetic resonance imaging (MRI) ability, but also further improve the sonodynamic ability of the TiO2 ...
March 23, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29324346/synthesis-and-biological-characterization-of-novel-rose-bengal-derivatives-with-improved-amphiphilicity-for-sono-photodynamic-therapy
#20
Hai-Jun Chen, Xiao-Bin Zhou, Ai-Lan Wang, Bi-Yuan Zheng, Chih-Kuang Yeh, Jian-Dong Huang
Sono-Photodynamic therapy (SPDT) utilizing ultrasound and light has been demonstrated that this novel approach can lower dosage resulting in reduction of the potential side effects caused by sensitizers. Recently, a new formulation of rose bengal (RB) as an intralesional injection has completed clinical trials phase II for PDT treatment of melanoma cancer. However, the inherent unfavorable pharmacological properties of RB hindered its extensive clinical development. With the aim to identify new RB derivatives (RBDs) with enhanced photodynamic and sonodynamic anticancer efficiency, a series of amphiphilic RBDs have been designed, synthesized and biological characterized...
February 10, 2018: European Journal of Medicinal Chemistry
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