keyword
MENU ▼
Read by QxMD icon Read
search

Biology pacing

keyword
https://www.readbyqxmd.com/read/28733909/genetics-molecular-and-proteomics-advances-in-filamentous-fungi
#1
REVIEW
Prakriti Sharma Ghimire, Cheng Jin
Filamentous fungi play a dynamic role in health and the environment. In addition, their unique and complex hyphal structures are involved in their morphogenesis, integrity, synthesis, and degradation, according to environmental and physiological conditions and resource availability. However, in biotechnology, it has a great value in the production of enzymes, pharmaceuticals, and food ingredients. The beginning of nomenclature of overall fungi started in early 1990 after which the categorization, interior and exterior mechanism, function, molecular and genetics study took pace...
July 22, 2017: Current Microbiology
https://www.readbyqxmd.com/read/28726731/the-use-of-imaging-in-the-prediction-and-assessment-of-cancer-treatment-toxicity
#2
REVIEW
Hossein Jadvar
Multimodal imaging is commonly used in the management of patients with cancer. Imaging plays pivotal roles in the diagnosis, initial staging, treatment response assessment, restaging after treatment and the prognosis of many cancers. Indeed, it is difficult to imagine modern precision cancer care without the use of multimodal molecular imaging, which is advancing at a rapid pace with innovative developments in imaging sciences and an improved understanding of the complex biology of cancer. Cancer therapy often leads to undesirable toxicity, which can range from an asymptomatic subclinical state to severe end organ damage and even death...
July 20, 2017: Diagnostics
https://www.readbyqxmd.com/read/28725482/systems-biology-driving-drug-development-from-design-to-the-clinical-testing-of-the-anti-erbb3-antibody-seribantumab-mm-121
#3
REVIEW
Birgit Schoeberl, Art Kudla, Kristina Masson, Ashish Kalra, Michael Curley, Gregory Finn, Emily Pace, Brian Harms, Jaeyeon Kim, Jeff Kearns, Aaron Fulgham, Olga Burenkova, Viara Grantcharova, Defne Yarar, Violette Paragas, Jonathan Fitzgerald, Marisa Wainszelbaum, Kip West, Sara Mathews, Rachel Nering, Bambang Adiwijaya, Gabriela Garcia, Bill Kubasek, Victor Moyo, Akos Czibere, Ulrik B Nielsen, Gavin MacBeath
The ErbB family of receptor tyrosine kinases comprises four members: epidermal growth factor receptor (EGFR/ErbB1), human EGFR 2 (HER2/ErbB2), ErbB3/HER3, and ErbB4/HER4. The first two members of this family, EGFR and HER2, have been implicated in tumorigenesis and cancer progression for several decades, and numerous drugs have now been approved that target these two proteins. Less attention, however, has been paid to the role of this family in mediating cancer cell survival and drug tolerance. To better understand the complex signal transduction network triggered by the ErbB receptor family, we built a computational model that quantitatively captures the dynamics of ErbB signaling...
2017: NPJ Systems Biology and Applications
https://www.readbyqxmd.com/read/28725029/prominent-differences-in-left-ventricular-performance-and-myocardial-properties-between-right-ventricular-and-left-ventricular-based-pacing-modes-in-rats
#4
Wesam Mulla, Sharon Etzion, Sigal Elyagon, Roni Gillis, Michael Murninkas, Yuval Konstantino, Ingra Mannhardt, Thomas Eschenhagen, Noah Liel-Cohen, Yoram Etzion
Biventricular pacing is an important modality to improve left ventricular (LV) synchronization and long-term function. However, the biological effects of this treatment are far from being elucidated and existing animal models are limited and demanding. Recently, we introduced an implanted device for double-site epicardial pacing in rats and echocardiographically demonstrated favorable effects of LV and biventricular (LV-based) pacing modes typically observed in humans. Here, this new animal model was further characterized...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28717530/comparative-and-integrative-analysis-of-rna-structural-profiling-data-current-practices-and-emerging-questions
#5
Krishna Choudhary, Fei Deng, Sharon Aviran
BACKGROUND: Structure profiling experiments provide single-nucleotide information on RNA structure. Recent advances in chemistry combined with application of high-throughput sequencing have enabled structure profiling at transcriptome scale and in living cells, creating unprecedented opportunities for RNA biology. Propelled by these experimental advances, massive data with ever-increasing diversity and complexity have been generated, which give rise to new challenges in interpreting and analyzing these data...
March 2017: Quantitative Biology
https://www.readbyqxmd.com/read/28717316/induced-pluripotent-stem-cell-a-headway-in-reprogramming-with-promising-approach-in-regenerative-biology
#6
REVIEW
N Rawat, M K Singh
Since the embryonic stem cells have knocked the doorsteps, they have proved themselves in the field of science, research, and medicines, but the hovered restrictions confine their application in human welfare. Alternate approaches used to reprogram the cells to the pluripotent state were not up to par, but the innovation of induced pluripotent stem cells (iPSCs) paved a new hope for the researchers. Soon after the discovery, iPSCs technology is undergoing renaissance day by day, i.e., from the use of genetic material to recombinant proteins and now only chemicals are employed to convert somatic cells to iPSCs...
June 2017: Veterinary World
https://www.readbyqxmd.com/read/28714074/altered-metabolomic-genomic-signature-a-potential-noninvasive-biomarker-of-epilepsy
#7
Helen C Wu, Fabien Dachet, Farhad Ghoddoussi, Shruti Bagla, Darren Fuerst, Jeffrey A Stanley, Matthew P Galloway, Jeffrey A Loeb
OBJECTIVE: This study aimed to identify noninvasive biomarkers of human epilepsy that can reliably detect and localize epileptic brain regions. Having noninvasive biomarkers would greatly enhance patient diagnosis, patient monitoring, and novel therapy development. At the present time, only surgically invasive, direct brain recordings are capable of detecting these regions with precision, which severely limits the pace and scope of both clinical management and research progress in epilepsy...
July 17, 2017: Epilepsia
https://www.readbyqxmd.com/read/28703295/expanding-career-pathways-in-conservation-science
#8
Erika Zavaleta, Clare Aslan, Wendy Palen, Tom Sisk, Maureen E Ryan, Brett Dickson
Since its inception, conservation biology has inspired thousands of students, spurred the creation of new initiatives, organizations and agencies, and informed conservation efforts worldwide. Nevertheless, global biodiversity loss is accelerating (Butchart et al. 2010), and our field needs to change to keep pace with mounting challenges. Conservation would benefit if scientists more enthusiastically pushed the institutional boundaries of our field through their efforts to expand their own and others' career options and professional opportunities...
July 13, 2017: Conservation Biology: the Journal of the Society for Conservation Biology
https://www.readbyqxmd.com/read/28693924/site-1-protease-and-lysosomal-homeostasis
#9
REVIEW
Renata Voltolini Velho, Raffaella De Pace, Sarah Klünder, Giorgia Di Lorenzo, Michaela Schweizer, Thomas Braulke, Sandra Pohl
The Golgi-resident site-1 protease (S1P) is a key regulator of cholesterol homeostasis and ER stress responses by converting latent transcription factors sterol regulatory element binding proteins (SREPBs) and activating transcription factor 6 (ATF6), as well as viral glycoproteins to their active forms. S1P is also essential for lysosome biogenesis by the proteolytic activation of the hexameric GlcNAc-1-phosphotransferase complex required for modification of newly synthesized lysosomal enzymes with the lysosomal targeting signal, mannose 6-phosphate...
July 7, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28679748/evolution-of-the-staphylococcus-argenteus-st2250-clone-in-northeastern-thailand-is-linked-with-the-acquisition-of-livestock-associated-staphylococcal-genes
#10
Danesh Moradigaravand, Dorota Jamrozy, Rafal Mostowy, Annaliesa Anderson, Emma K Nickerson, Janjira Thaipadungpanit, Vanaporn Wuthiekanun, Direk Limmathurotsakul, Sarunporn Tandhavanant, Chanthiwa Wikraiphat, Gumphol Wongsuvan, Nittaya Teerawattanasook, Yaowaruk Jutrakul, Nuttiya Srisurat, Prajuab Chaimanee, T Eoin West, Beth Blane, Julian Parkhill, Narisara Chantratita, Sharon J Peacock
Staphylococcus argenteus is a newly named species previously described as a divergent lineage of Staphylococcus aureus that has recently been shown to have a global distribution. Despite growing evidence of the clinical importance of this species, knowledge about its population epidemiology and genomic architecture is limited. We used whole-genome sequencing to evaluate and compare S. aureus (n = 251) and S. argenteus (n = 68) isolates from adults with staphylococcal sepsis at several hospitals in northeastern Thailand between 2006 and 2013...
July 5, 2017: MBio
https://www.readbyqxmd.com/read/28671948/stochasticity-in-the-enterococcal-sex-pheromone-response-revealed-by-quantitative-analysis-of-transcription-in-single-cells
#11
Rebecca J Breuer, Arpan Bandyopadhyay, Sofie A O'Brien, Aaron M T Barnes, Ryan C Hunter, Wei-Shou Hu, Gary M Dunny
In Enterococcus faecalis, sex pheromone-mediated transfer of antibiotic resistance plasmids can occur under unfavorable conditions, for example, when inducing pheromone concentrations are low and inhibiting pheromone concentrations are high. To better understand this paradox, we adapted fluorescence in situ hybridization chain reaction (HCR) methodology for simultaneous quantification of multiple E. faecalis transcripts at the single cell level. We present direct evidence for variability in the minimum period, maximum response level, and duration of response of individual cells to a specific inducing condition...
July 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28664386/novel-therapies-for-acute-myeloid-leukemia-are-we-finally-breaking-the-deadlock
#12
REVIEW
Maximilian Stahl, Benjamin Y Lu, Tae Kon Kim, Amer M Zeidan
Acute myeloid leukemia (AML) is one of the best studied malignancies, and significant progress has been made in understanding the clinical implications of its disease biology. Unfortunately, drug development has not kept pace, as the '7+3' induction regimen remains the standard of care for patients fit for intensive therapy 40 years after its first use. Temporal improvements in overall survival were mostly confined to younger patients and driven by improvements in supportive care and use of hematopoietic stem cell transplantation...
June 29, 2017: Targeted Oncology
https://www.readbyqxmd.com/read/28662052/can-cancer-researchers-accurately-judge-whether-preclinical-reports-will-reproduce
#13
Daniel Benjamin, David R Mandel, Jonathan Kimmelman
There is vigorous debate about the reproducibility of research findings in cancer biology. Whether scientists can accurately assess which experiments will reproduce original findings is important to determining the pace at which science self-corrects. We collected forecasts from basic and preclinical cancer researchers on the first 6 replication studies conducted by the Reproducibility Project: Cancer Biology (RP:CB) to assess the accuracy of expert judgments on specific replication outcomes. On average, researchers forecasted a 75% probability of replicating the statistical significance and a 50% probability of replicating the effect size, yet none of these studies successfully replicated on either criterion (for the 5 studies with results reported)...
June 2017: PLoS Biology
https://www.readbyqxmd.com/read/28655887/comparative-proteome-analysis-between-c-briggsae-embryos-and-larvae-reveals-a-role-of-chromatin-modification-proteins-in-embryonic-cell-division
#14
Xiaomeng An, Jiaofang Shao, Huoming Zhang, Xiaoliang Ren, Vincy Wing Sze Ho, Runsheng Li, Ming-Kin Wong, Zhongying Zhao
Caenorhabditis briggsae has emerged as a model for comparative biology against model organism C. elegans. Most of its cell fate specifications are completed during embryogenesis whereas its cell growth is achieved mainly in larval stages. The molecular mechanism underlying the drastic developmental changes is poorly understood. To gain insights into the molecular changes between the two stages, we compared the proteomes between the two stages using iTRAQ. We identified a total of 2,791 proteins in the C. briggsae embryos and larvae, 247 of which undergo up- or down-regulation between the two stages...
June 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28647490/sex-biased-eicosanoid-biology-impact-for-sex-differences-in-inflammation-and-consequences-for-pharmacotherapy
#15
REVIEW
Simona Pace, Lidia Sautebin, Oliver Werz
The incidence, severity and progression of autoimmune diseases (e.g. scleroderma, multiple sclerosis, rheumatoid arthritis) and certain inflammatory diseases (e.g. asthma) are sex-biased where these pathologies dominate in women. However, other immune disorders such as sepsis, post-surgery infections and gout display higher incidence and severity in men. The molecular and cellular basis underlying this sex dimorphism remains incompletely elucidated but may provide important insights for sex-specific pharmacotherapy...
June 21, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28646653/cryo-em-beyond-the-microscope
#16
REVIEW
Lesley A Earl, Veronica Falconieri, Jacqueline Ls Milne, Sriram Subramaniam
The pace at which cryo-EM is being adopted as a mainstream tool in structural biology has continued unabated over the past year. Initial successes in obtaining near-atomic resolution structures with cryo-EM were enabled to a large extent by advances in microscope and detector technology. Here, we review some of the complementary technical improvements that are helping sustain the cryo-EM revolution. We highlight advances in image processing that permit high resolution structure determination even in the presence of structural and conformational heterogeneity...
June 21, 2017: Current Opinion in Structural Biology
https://www.readbyqxmd.com/read/28632278/paper-microfluidics-for-nucleic-acid-amplification-testing-naat-of-infectious-diseases
#17
Laura Magro, Camille Escadafal, Pierre Garneret, Béatrice Jacquelin, Aurélia Kwasiborski, Jean-Claude Manuguerra, Fabrice Monti, Anavaj Sakuntabhai, Jessica Vanhomwegen, Pierre Lafaye, Patrick Tabeling
The diagnosis of infectious diseases is entering a new and interesting phase. Technologies based on paper microfluidics, coupled to developments in isothermal amplification of Nucleic Acids (NAs) raise opportunities for bringing the methods of molecular biology in the field, in a low setting environment. A lot of work has been performed in the domain over the last few years and the landscape of contributions is rich and diverse. Most often, the level of sample preparation differs, along with the sample nature, the amplification and detection methods, and the design of the device, among other features...
June 20, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28619182/evolution-of-circadian-rhythms-from-bacteria-to-human
#18
REVIEW
Utpal Bhadra, Nirav Thakkar, Paromita Das, Manika Pal Bhadra
The human body persists in its rhythm as per its initial time zone, and transition always occur according to solar movements around the earth over 24 h. While traveling across different latitudes and longitudes, at the pace exceeding the earth's movement, the changes in the external cues exceed the level of toleration of the body's biological clock. This poses an alteration in our physiological activities of sleep-wake pattern, mental alertness, organ movement, and eating habits, causing them to temporarily lose the track of time...
July 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28618197/analysis-of-mutant-allele-fractions-in-driver-genes-in-colorectal-cancer-biological-and-clinical-insights
#19
Rodrigo Dienstmann, Elena Elez, Guillem Argiles, Ignacio Matos, Enrique Sanz-Garcia, Carolina Ortiz, Teresa Macarulla, Jaume Capdevila, Maria Alsina, Tamara Sauri, Helena Verdaguer, Marta Vilaro, Fiorella Ruiz-Pace, Cristina Viaplana, Ariadna Garcia, Stefania Landolfi, Hector G Palmer, Paolo Nuciforo, Jordi Rodon, Ana Vivancos, Josep Tabernero
Sequencing of tumors is now routine and guides personalized cancer therapy. Mutant allele fractions (MAFs, or the 'mutation dose') of a driver gene may reveal the genomic structure of tumors and influence response to targeted therapies. We performed a comprehensive analysis of MAFs of driver alterations in unpaired primary and metastatic colorectal cancer (CRC) at our institution from 2010 to 2015 and studied their potential clinical relevance. Out of 763 CRC samples, 622 had detailed annotation on overall survival in the metastatic setting (OSmet) and 89 received targeted agents matched to KRAS (MEK inhibitors), BRAF (BRAF inhibitors) or PIK3CA mutations (PI3K pathway inhibitors)...
June 15, 2017: Molecular Oncology
https://www.readbyqxmd.com/read/28591070/emerging-gastrointestinal-and-liver-diseases-in-asia-pacific-implications-to-health-care-in-the-region-world-gastroenterology-organization-asian-pacific-association-of-gastroenterology-distinguished-global-lecture-2015
#20
Khean-Lee Goh
Colorectal cancer (CRC), gastroesophageal reflux disease (GERD), inflammatory bowel disease (IBD), and nonalcoholic fatty liver disease are considered important emerging diseases in the Asia Pacific (AP) region. The incidence rate of CRC is the highest among gastrointestinal cancers in the region surpassing that of gastric cancer. However, population CRC screening is limited by availability of adequate health resources and financing. GERD is a highly prevalent disease in AP with the prevalence of GERD symptoms and reflux esophagitis reported to be increasing...
July 2017: Journal of Clinical Gastroenterology
keyword
keyword
9141
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"