keyword
MENU ▼
Read by QxMD icon Read
search

Biology pacing

keyword
https://www.readbyqxmd.com/read/29045685/micrornas-and-complex-diseases-from-experimental-results-to-computational-models
#1
Xing Chen, Di Xie, Qi Zhao, Zhu-Hong You
Plenty of microRNAs (miRNAs) were discovered at a rapid pace in plants, green algae, viruses and animals. As one of the most important components in the cell, miRNAs play a growing important role in various essential and important biological processes. For the recent few decades, amounts of experimental methods and computational models have been designed and implemented to identify novel miRNA-disease associations. In this review, the functions of miRNAs, miRNA-target interactions, miRNA-disease associations and some important publicly available miRNA-related databases were discussed in detail...
October 17, 2017: Briefings in Bioinformatics
https://www.readbyqxmd.com/read/29034606/do-mid-crown-enamel-formation-front-angles-reflect-factors-linked-to-the-pace-of-primate-growth-and-development
#2
Debbie Guatelli-Steinberg, James D Pampush, Mackie C O'Hara, Song Xing, W Scott McGraw, Rebecca J Ferrell
Enamel formation front (EFF) angles represent the leading edge of enamel matrix secretion at particular points in time. These angles are influenced by rates of enamel extension (the rates at which tooth crowns grow in height), rates of enamel matrix secretion and the angles that prisms make with the enamel-dentine junction. Previous research suggests, but has not yet established, that these angles reflect aspects of primate biology related to their pace of growth and development, most notably brain and body size...
October 16, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29029599/liverwiki-a-wiki-based-database-for-human-liver
#3
Tao Chen, Mansheng Li, Qiang He, Lei Zou, Youhuan Li, Cheng Chang, Dongyan Zhao, Yunping Zhu
BACKGROUND: Recent advances in omics technology have produced a large amount of liver-related data. A comprehensive and up-to-date source of liver-related data is needed to allow biologists to access the latest data. However, current liver-related data sources each cover only a specific part of the liver. It is difficult for them to keep pace with the rapid increase of liver-related data available at those data resources. Integrating diverse liver-related data is a critical yet formidable challenge, as it requires sustained human effort...
October 13, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/29026100/a-new-semi-supervised-learning-model-combined-with-cox-and-sp-aft-models-in-cancer-survival-analysis
#4
Hua Chai, Zi-Na Li, De-Yu Meng, Liang-Yong Xia, Yong Liang
Gene selection is an attractive and important task in cancer survival analysis. Most existing supervised learning methods can only use the labeled biological data, while the censored data (weakly labeled data) far more than the labeled data are ignored in model building. Trying to utilize such information in the censored data, a semi-supervised learning framework (Cox-AFT model) combined with Cox proportional hazard (Cox) and accelerated failure time (AFT) model was used in cancer research, which has better performance than the single Cox or AFT model...
October 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29017160/role-of-molecular-biology-in-diagnosis-and-characterization-of-vulvo-vaginitis-in-clinical-practice
#5
Gilbert G G Donders, Jacques Ravel, Beatrice Vitali, Mihai G Netea, Andres Salumets, Magnus Unemo
The diagnosis of vulvo-vaginal complaints has always been enigmatic in obstetrics and gynecology. Patients with clear, pathognomonic symptoms end up with a proper diagnosis and treatment most of the time, but unfortunately we are now living in a world where women reach out to the Internet and readily get all information as to which disease their symptoms correspond to and also find the appropriate treatment "over-the-counter." Because of this trend, we as specialists are increasingly confronted with patients with complex and combined conditions...
October 10, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/29016845/pediatric-low-grade-gliomas-next-biologically-driven-steps
#6
David T W Jones, Mark W Kieran, Eric Bouffet, Sanda Alexandrescu, Pratiti Bandopadhayay, Miriam Bornhorst, David Ellison, Jason Fangusaro, Michael I Fisher, Nicholas Foreman, Maryam Fouladi, Darren Hargrave, Cynthia Hawkins, Nada Jabado, Maura Massimino, Sabine Mueller, Giorgio Perilongo, Antoinette Y N Schouten-van Meeteren, Uri Tabori, Katherine Warren, Angela J Waanders, David Walker, William Weiss, Olaf Witt, Karen Wright, Yuan Zhu, Daniel C Bowers, Stefan M Pfister, Roger J Packer
Despite the fact that they are not typically life-threatening, low-grade gliomas (LGGs) remain a significant clinical challenge in pediatric neurooncology due to co-morbidities associated with these tumors and/or their treatments, and their propensity to multiply recur. LGGs, in total the most common brain tumors arising in childhood, can often become a chronic problem requiring decades of management. The 2nd international consensus conference on pediatric low-grade gliomas held in Padua, Italy in 2016, was convened in an attempt to advance the pace of translating biological discoveries on LGGs into meaningful clinical benefit...
August 2, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28994170/why-decadal-to-century-timescale-paleoclimate-data-is-needed-to-explain-present-day-patterns-of-biological-diversity-and-change
#7
Damien A Fordham, Frédérik Saltré, Stuart C Brown, Camille Mellin, Tom M L Wigley
The current distribution of species, environmental conditions and their interactions represent only one snapshot of a planet that is continuously changing, in part due to human influences. To distinguish human impacts from natural factors, the magnitude and pace of climate shifts since the Last Glacial Maximum are often used to determine whether patterns of diversity today are artefacts of past climate change. In the absence of high-temporal-resolution paleoclimate reconstructions, this is generally done by assuming that past climate change occurred at a linear pace between widely spaced (usually, ≥ 1,000 years) climate snapshots...
October 10, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28993175/research-to-knowledge-promoting-the-training%C3%A2-of-physician-scientists-in-the-biology%C3%A2-of%C3%A2-pregnancy
#8
Yoel Sadovky, Aaron B Caughey, Michelle DiVito, Mary E D'Alton, Amy P Murtha
Common disorders of pregnancy, such as preeclampsia, preterm birth, and fetal growth abnormalities, continue to challenge perinatal biologists seeking insights into disease pathogenesis that will result in better diagnosis, therapy, and disease prevention. These challenges have recently been intensified with discoveries that associate gestational diseases with long-term maternal and neonatal outcomes. Whereas modern high-throughput investigative tools enable scientists and clinicians to noninvasively probe the maternal-fetal genome, epigenome, and other analytes, their implications for clinical medicine remain uncertain...
October 7, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28989794/a-marker-of-biological-age-explains-individual-variation-in-the-strength-of-the-adult-stress-response
#9
Clare Andrews, Daniel Nettle, Maria Larriva, Robert Gillespie, Sophie Reichert, Ben O Brilot, Thomas Bedford, Pat Monaghan, Karen A Spencer, Melissa Bateson
The acute stress response functions to prioritize behavioural and physiological processes that maximize survival in the face of immediate threat. There is variation between individuals in the strength of the adult stress response that is of interest in both evolutionary biology and medicine. Age is an established source of this variation-stress responsiveness diminishes with increasing age in a range of species-but unexplained variation remains. Since individuals of the same chronological age may differ markedly in their pace of biological ageing, we asked whether biological age-measured here via erythrocyte telomere length-predicts variation in stress responsiveness in adult animals of the same chronological age...
September 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28984673/toward-biological-subtyping-of-papillary-renal-cell-carcinoma-with-clinical-implications-through-histologic-immunohistochemical-and-molecular-analysis
#10
Rola M Saleeb, Fadi Brimo, Mina Farag, Alexis Rompré-Brodeur, Fabio Rotondo, Vidya Beharry, Samantha Wala, Pamela Plant, Michelle R Downes, Kenneth Pace, Andrew Evans, Georg Bjarnason, John M S Bartlett, George M Yousef
Papillary renal cell carcinoma (PRCC) has 2 histologic subtypes. Almost half of the cases fail to meet all morphologic criteria for either type, hence are characterized as PRCC not otherwise specified (NOS). There are yet no markers to resolve the PRCC NOS category. Accurate classification can better guide the management of these patients. In our previous PRCC study we identified markers that can distinguish between the subtypes. A PRCC patient cohort of 108 cases was selected for the current study. A panel of potentially distinguishing markers was chosen from our previous genomic analysis, and assessed by immunohistochemistry...
October 3, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28981844/uncertainty-on-radiation-doses-estimated-by-biological-and-retrospective-physical-methods
#11
Elizabeth A Ainsbury, Daniel Samaga, Sara Della Monaca, Maurizio Marrale, Celine Bassinet, Christopher I Burbidge, Virgilio Correcher, Michael Discher, Jon Eakins, Paola Fattibene, Inci Güçlü, Manuel Higueras, Eva Lund, Nadica Maltar-Strmecki, Stephen McKeever, Christopher L Rääf, Sergey Sholom, Ivan Veronese, Albrecht Wieser, Clemens Woda, Francois Trompier
Biological and physical retrospective dosimetry are recognised as key techniques to provide individual estimates of dose following unplanned exposures to ionising radiation. Whilst there has been a relatively large amount of recent development in the biological and physical procedures, development of statistical analysis techniques has failed to keep pace. The aim of this paper is to review the current state of the art in uncertainty analysis techniques across the 'EURADOS Working Group 10-Retrospective dosimetry' members, to give concrete examples of implementation of the techniques recommended in the international standards, and to further promote the use of Monte Carlo techniques to support characterisation of uncertainties...
September 18, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/28955254/android-robot-mediated-mock-job-interview-sessions-for-young-adults-with-autism-spectrum-disorder-a-pilot-study
#12
Hirokazu Kumazaki, Zachary Warren, Blythe A Corbett, Yuichiro Yoshikawa, Yoshio Matsumoto, Haruhiro Higashida, Teruko Yuhi, Takashi Ikeda, Hiroshi Ishiguro, Mitsuru Kikuchi
The feasibility and preliminary efficacy of an android robot-mediated mock job interview training in terms of both bolstering self-confidence and reducing biological levels of stress in comparison to a psycho-educational approach human interview was assessed in a randomized study. Young adults (ages 18-25 years) with autism spectrum disorder (ASD) were randomized to participate either in a mock job interview training with our android robot system (n = 7) or a self-paced review of materials about job-interviewing skills (n = 8)...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28919372/biological-applications-of-kinetics-of-wetting-and-spreading
#13
REVIEW
G Ahmed, O Arjmandi Tash, J Cook, A Trybala, V Starov
Wetting and spreading kinetics of biological fluids has gained a substantial interest recently. The importance of these fluids in our lives has driven the pace of publications. Globally scientists have ever growing interest in understanding wetting phenomena due to its vast applications in biological fluids. It is impractical to review extremely large number of publications in the field of kinetics of complex biological fluids and cosmetic solutions on diverse surfaces. Therefore, biological and cosmetic applications of wetting and spreading dynamics are considered in the following areas: (i) Spreading of Newtonian liquids in the case of non-porous and porous substrates...
August 18, 2017: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/28914388/diet-has-independent-effects-on-the-pace-and-shape-of-aging-in-drosophila-melanogaster
#14
C Ruth Archer, Ugofilippo Basellini, John Hunt, Stephen J Simpson, Kwang Pum Lee, Annette Baudisch
Studies examining how diet affects mortality risk over age typically characterise mortality using parameters such as aging rates, which condense how much and how quickly the risk of dying changes over time into a single measure. Demographers have suggested that decoupling the tempo and the magnitude of changing mortality risk may facilitate comparative analyses of mortality trajectories, but it is unclear what biologically meaningful information this approach offers. Here, we determine how the amount and ratio of protein and carbohydrate ingested by female Drosophila melanogaster affects how much mortality risk increases over a time-standardised life-course (the shape of aging) and the tempo at which animals live and die (the pace of aging)...
September 15, 2017: Biogerontology
https://www.readbyqxmd.com/read/28901970/the-2016-who-classification-of-central-nervous-system-tumors-what-neurologists-need-to-know
#15
John C DeWitt, Andreas Mock, David N Louis
PURPOSE OF REVIEW: The 2016 WHO classification of tumors of the central nervous system (2016 CNS WHO) features many changes that are relevant to neurologists treating patients with brain tumors as well as neurologists involved in basic, clinical, and epidemiological research. This review summarizes what neurologists need to know and will need to know in the next years. RECENT FINDINGS: The 2016 CNS WHO introduces diagnostic terms that 'integrate' histological and molecular information and suggests presenting diagnoses in a four-layered reporting format...
September 9, 2017: Current Opinion in Neurology
https://www.readbyqxmd.com/read/28852965/traumatic-stress-and-accelerated-cellular-aging-from-epigenetics-to-cardiometabolic-disease
#16
REVIEW
Erika J Wolf, Filomene G Morrison
PURPOSE OF REVIEW: The aim of this paper is to review the recent literature on traumatic stress-related accelerated aging, including a focus on cellular mechanisms and biomarkers of cellular aging and on the clinical manifestations of accelerated biological aging. RECENT FINDINGS: Multiple lines of research converge to suggest that PTSD is associated with accelerated aging in the epigenome, and the immune and inflammation systems, and this may be reflected in premature onset of cardiometabolic and cardiovascular disease...
August 29, 2017: Current Psychiatry Reports
https://www.readbyqxmd.com/read/28839915/domestication-as-a-model-system-for-the-extended-evolutionary-synthesis
#17
REVIEW
Melinda A Zeder
One of the challenges in evaluating arguments for extending the conceptual framework of evolutionary biology involves the identification of a tractable model system that allows for an assessment of the core assumptions of the extended evolutionary synthesis (EES). The domestication of plants and animals by humans provides one such case study opportunity. Here, I consider domestication as a model system for exploring major tenets of the EES. First I discuss the novel insights that niche construction theory (NCT, one of the pillars of the EES) provides into the domestication processes, particularly as they relate to five key areas: coevolution, evolvability, ecological inheritance, cooperation and the pace of evolutionary change...
October 6, 2017: Interface Focus
https://www.readbyqxmd.com/read/28839914/adaptability-and-evolution
#18
REVIEW
Patrick Bateson
The capacity of organisms to respond in their own lifetimes to new challenges in their environments probably appeared early in biological evolution. At present few studies have shown how such adaptability could influence the inherited characteristics of an organism's descendants. In part, this has been because organisms have been treated as passive in evolution. Nevertheless, their effects on biological evolution are likely to have been important and, when they occurred, accelerated the pace of evolution. Ways in which this might have happened have been suggested many times since the 1870s...
October 6, 2017: Interface Focus
https://www.readbyqxmd.com/read/28815588/the-tooth-the-whole-tooth-and-nothing-but-the-tooth-tooth-shape-and-ontogenetic-shift-dynamics-in-the-white-shark-carcharodon-carcharias
#19
G C A French, M Stürup, S Rizzuto, J H van Wyk, D Edwards, R W Dolan, S P Wintner, A V Towner, W O H Hughes
Results from this study of the white shark Carcharodon carcharias include measurements obtained using a novel photographic method that reveal significant differences between the sexes in the relationship between tooth cuspidity and shark total length, and a novel ontogenetic change in male tooth shape. Males exhibit broader upper first teeth and increased distal inclination of upper third teeth with increasing length, while females do not present a consistent morphological change. Substantial individual variation, with implications for pace of life syndrome, was present in males and tooth polymorphism was suggested in females...
August 17, 2017: Journal of Fish Biology
https://www.readbyqxmd.com/read/28813554/association-between-purpose-in-life-and-objective-measures-of-physical-function-in-older-adults
#20
Eric S Kim, Ichiro Kawachi, Ying Chen, Laura D Kubzansky
Importance: Higher purpose in life is hypothesized to reduce the likelihood of developing weak grip strength and slow walking speed because purpose has been linked with a range of positive health behaviors and biological processes that are potentially protective against declining physical function. However, the association between purpose in life and objective physical function has not been examined. Objective: To assess whether higher purpose in life among adequately functioning older adults is associated with lower risk of developing weak grip strength and slow walking speed over time...
October 1, 2017: JAMA Psychiatry
keyword
keyword
9141
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"