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Zou, Weiping

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https://www.readbyqxmd.com/read/28327662/regulation-of-hepatic-lipogenesis-by-the-zinc-finger-protein-zbtb20
#1
Gan Liu, Luting Zhou, Hai Zhang, Rong Chen, Ye Zhang, Ling Li, Jun-Yu Lu, Hui Jiang, Dong Liu, Shasha Qi, Ying-Ming Jiang, Kai Yin, Zhifang Xie, Yuguang Shi, Yong Liu, Xuetao Cao, Yu-Xia Chen, Dajin Zou, Weiping J Zhang
Hepatic de novo lipogenesis (DNL) converts carbohydrates into triglycerides and is known to influence systemic lipid homoeostasis. Here, we demonstrate that the zinc finger protein Zbtb20 is required for DNL. Mice lacking Zbtb20 in the liver exhibit hypolipidemia and reduced levels of liver triglycerides, along with impaired hepatic lipogenesis. The expression of genes involved in glycolysis and DNL, including that of two ChREBP isoforms, is decreased in livers of knockout mice. Zbtb20 binds to and enhances the activity of the ChREBP-α promoter, suggesting that altered metabolic gene expression is mainly driven by ChREBP...
March 22, 2017: Nature Communications
https://www.readbyqxmd.com/read/28249897/il-33-promotes-colon-cancer-cell-stemness-via-jnk-activation-and-macrophage-recruitment
#2
Min Fang, Yongkui Li, Kai Huang, Shanshan Qi, Jian Zhang, Witold Zgodzinski, Marek Majewski, Grzegorz Wallner, Stanislaw Gozdz, Pawel Macek, Artur Kowalik, Marcin Pasiarski, Ewelina Grywalska, Linda Vatan, Nisha Nagarsheth, Wei Li, Lili Zhao, Ilona Kryczek, Guobin Wang, Zheng Wang, Weiping Zou, Lin Wang
The expression and biological role of IL-33 in colon cancer is poorly understood. In this study, we show that IL-33 is expressed by vascular endothelial cells and tumor cells in the human colon cancer microenvironment. Administration of human IL-33 and overexpression of murine IL-33 enhanced human and murine colon cancer cell growth in vivo, respectively. IL-33 stimulated cell sphere formation and prevented chemotherapy-induced tumor apoptosis. Mechanistically, IL-33 activated core stem cell genes NANOG, NOTCH3, and OCT3/4 via the ST2 signaling pathway, and induced phosphorylation of c-Jun N-terminal kinase activation (JNK), and enhanced binding of c-Jun to the promoters of the core stem cell genes...
March 1, 2017: Cancer Research
https://www.readbyqxmd.com/read/28247319/unloading-of-cryoprotectants-from-cryoprotectant-loaded-cells-on-a-microfluidic-platform
#3
Yufeng Kang, Lili Zou, Bensheng Qiu, Xin Liang, Sijie Sun, Dayong Gao, Weiping Ding
In this paper, a multistep dilution-filtration microdevice (MDFD) is developed for unloading cryoprotectants from cryoprotectant-loaded cells. The MDFD contained a diluent producing region, a dilution-filtration execution region, and a filtrate collection region. It was made of two patterned PMMA stamps with four pieces of sandwiched PVDF membranes. Firstly, the performances of the mixers that were used in the diluent producing region and the dilution-filtration execution region were assessed using fluorescence experiments...
June 2017: Biomedical Microdevices
https://www.readbyqxmd.com/read/28230322/comparative-effectiveness-and-safety-of-different-basal-insulins-in-a-real-world-setting
#4
Linong Ji, Puhong Zhang, Dongshan Zhu, Juming Lu, Xiaohui Guo, Yangfeng Wu, Xian Li, Jiachao Ji, Weiping Jia, Wenying Yang, Dajin Zou, Zhiguang Zhou, Yan Gao, Satish K Garg, Changyu Pan, Jianping Weng, Sanjoy K Paul
AIMS: To compare glucose control and safety of different basal insulin (BI, including Insulin NPH, glargine and detemir) therapies in real-life clinical settings based on a large-scale registry study. METHODS: In this multi-center 6-month prospective observational study, patients with type 2 diabetes uncontrolled (HbA1c≥7%) by oral anti-diabetic drugs (OADs) and willing to initiate BI were enrolled from 209 hospitals of eight regions of China. Type and dose of BI were at the physician's discretion and patients' willingness...
February 23, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28105735/observational-registry-of-basal-insulin-treatment-orbit-in-patients-with-type-2-diabetes-uncontrolled-with-oral-antihyperglycaemic-drugs-real-life-use-of-basal-insulin-in-china
#5
Linong Ji, Puhong Zhang, Dongshan Zhu, Xian Li, Jiachao Ji, Juming Lu, Xiaohui Guo, Weiping Jia, Jianping Weng, Yangfeng Wu, Wenying Yang, Dajin Zou, Zhiguang Zhou, Changyu Pan, Yan Gao, Satish K Garg
AIMS: To examine treatment patterns following basal insulin (BI) introduction in type 2 diabetes mellitus (T2DM) patients under real-world conditions across China. MATERIALS AND METHODS: Overall, 18,995 patients inadequately controlled [HbA1c ≥ 53 mmol/mol (7%)] with oral antihyperglycaemic drugs (OADs) and willing to receive BI treatment were registered at 209 hospitals and followed at baseline (visit 1), 3 months (visit 2), and 6 months (visit 3). Type of BI was initiated at physicians' discretion...
January 20, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28039324/topoisomerase-3%C3%AE-is-the-major-topoisomerase-for-mrnas-and-linked-to-neurodevelopment-and-mental-dysfunction
#6
Muzammil Ahmad, Weiping Shen, Wen Li, Yutong Xue, Sige Zou, Dongyi Xu, Weidong Wang
Human cells contain five topoisomerases in the nucleus and cytoplasm, but which one is the major topoisomerase for mRNAs is unclear. To date, Top3β is the only known topoisomerase that possesses RNA topoisomerase activity, binds mRNA translation machinery and interacts with an RNA-binding protein, FMRP, to promote synapse formation; and Top3β gene deletion has been linked to schizophrenia. Here, we show that Top3β is also the most abundant mRNA-binding topoisomerase in cells. Top3β, but not other topoisomerases, contains a distinctive RNA-binding domain; and deletion of this domain diminishes the amount of Top3β that associates with mRNAs, indicating that Top3β is specifically targeted to mRNAs by its RNA binding domain...
December 29, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27889317/the-p53-family-coordinates-wnt-and-nodal-inputs-in-mesendodermal-differentiation-of-embryonic-stem-cells
#7
Qiong Wang, Yilong Zou, Sonja Nowotschin, Sang Yong Kim, Qing V Li, Chew-Li Soh, Jie Su, Chao Zhang, Weiping Shu, Qiaoran Xi, Danwei Huangfu, Anna-Katerina Hadjantonakis, Joan Massagué
In this study, we outline a regulatory network that involves the p53 tumor suppressor family and the Wnt pathway acting together with the TGF-β pathway in mesendodermal differentiation of mouse and human embryonic stem cells. Knockout of all three members, p53, p63, and p73, shows that the p53 family is essential for mesendoderm specification during exit from pluripotency in embryos and in culture. Wnt3 and its receptor Fzd1 are direct p53 family target genes in this context, and induction of Wnt signaling by p53 is critical for activation of mesendodermal differentiation genes...
January 5, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/27678067/characterization-and-expression-profiling-of-atp-binding-cassette-transporter-genes-in-the-diamondback-moth-plutella-xylostella-l
#8
Weiping Qi, Xiaoli Ma, Weiyi He, Wei Chen, Mingmin Zou, Geoff M Gurr, Liette Vasseur, Minsheng You
BACKGROUND: ATP-binding cassette (ABC) transporters are one of the major transmembrane protein families found in all organisms and play important roles in transporting a variety of compounds across intra and extra cellular membranes. In some species, ABC transporters may be involved in the detoxification of substances such as insecticides. The diamondback moth, Plutella xylostella (L.), a destructive pest of cruciferous crops worldwide, is an important species to study as it is resistant to many types of insecticides as well as biological control Bacillus thuringiensis toxins...
September 27, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27622054/inflammatory-regulatory-t-cells-in-the-microenvironments-of-ulcerative-colitis-and-colon-carcinoma
#9
Ilona Kryczek, Lin Wang, Ke Wu, Wei Li, Ende Zhao, Tracy Cui, Shuang Wei, Yan Liu, Yin Wang, Linda Vatan, Wojciech Szeliga, Joel K Greenson, Jacek Roliński, Witold Zgodzinski, Emina Huang, Kaixiong Tao, Guobin Wang, Weiping Zou
Foxp3(+)CD4(+) regulatory T (Treg) cells are thought to express negligible levels of effector cytokines, and inhibit immune responses and inflammation. Here, we have identified a population of IL-8(+)Foxp3(+)CD4(+) T cells in human peripheral blood, which is selectively increased in the microenvironments of ulcerative colitis and colon carcinoma. Phenotypically, this population is minimally overlapping with IL-17(+)Foxp3(+)CD4(+) T cells, and is different from IL-8(-)Foxp3(+)CD4(+) T cells in the same microenvironment...
August 2016: Oncoimmunology
https://www.readbyqxmd.com/read/27622053/th22-cells-control-colon-tumorigenesis-through-stat3-and-polycomb-repression-complex-2-signaling
#10
Danfeng Sun, Yanwei Lin, Jie Hong, Haoyan Chen, Nisha Nagarsheth, Dongjun Peng, Shuang Wei, Emina Huang, Jingyuan Fang, Ilona Kryczek, Weiping Zou
Th22 cells traffic to and retain in the colon cancer microenvironment, and target core stem cell genes and promote colon cancer stemness via STAT3 and H3K79me2 signaling pathway and contribute to colon carcinogenesis. However, whether Th22 cells affect colon cancer cell proliferation and apoptosis remains unknown. We studied the interaction between Th22 cells and colon cancer cells in the colon cancer microenvironment. Colon cancer proliferation was examined by flow cytometry analysis and H(3) thymidine incorporation...
August 2016: Oncoimmunology
https://www.readbyqxmd.com/read/27607151/self-powered-one-stop-and-multifunctional-implantable-triboelectric-active-sensor-for-real-time-biomedical-monitoring
#11
Ye Ma, Qiang Zheng, Yang Liu, Bojin Shi, Xiang Xue, Weiping Ji, Zhuo Liu, Yiming Jin, Yang Zou, Zhao An, Wei Zhang, Xinxin Wang, Wen Jiang, Zhiyun Xu, Zhong Lin Wang, Zhou Li, Hao Zhang
Operation time of implantable electronic devices is largely constrained by the lifetime of batteries, which have to be replaced periodically by surgical procedures once exhausted, causing physical and mental suffering to patients and increasing healthcare costs. Besides the efficient scavenging of the mechanical energy of internal organs, this study proposes a self-powered, flexible, and one-stop implantable triboelectric active sensor (iTEAS) that can provide continuous monitoring of multiple physiological and pathological signs...
October 12, 2016: Nano Letters
https://www.readbyqxmd.com/read/27464265/standards-of-care-for-type-2-diabetes-in-china
#12
Jianping Weng, Linong Ji, Weiping Jia, Juming Lu, Zhiguang Zhou, Dajin Zou, Dalong Zhu, Liming Chen, Li Chen, Lixin Guo, Xiaohui Guo, Qiuhe Ji, Qifu Li, Xiaoying Li, Jing Liu, Xingwu Ran, Zhongyan Shan, Lixin Shi, Guangyao Song, Liyong Yang, Yuzhi Yang, Wenying Yang
No abstract text is available yet for this article.
July 2016: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/27463284/tp53-dependent-autophagy-links-the-atr-chek1-axis-activation-to-proinflammatory-vegfa-production-in-human-bronchial-epithelial-cells-exposed-to-fine-particulate-matter-pm2-5
#13
Xiuduan Xu, Hongli Wang, Shasha Liu, Chen Xing, Yang Liu, Aodengqimuge, Wei Zhou, Xiaoyan Yuan, Yongfu Ma, Meiru Hu, Yongliang Hu, Shuxian Zou, Ye Gu, Shuangqing Peng, Shengtao Yuan, Weiping Li, Yuanfang Ma, Lun Song
ABSTARCT Epidemiological and clinical studies have increasingly shown that fine particulate matter (PM2.5) is associated with a number of pathological respiratory diseases, such as bronchitis, asthma, and chronic obstructive pulmonary disease, which share the common feature of airway inflammation induced by particle exposure. Thus, understanding how PM2.5 triggers inflammatory responses in the respiratory system is crucial for the study of PM2.5 toxicity. In the current study, we found that exposing human bronchial epithelial cells (immortalized Beas-2B cells and primary cells) to PM2...
October 2, 2016: Autophagy
https://www.readbyqxmd.com/read/27374619/topical-and-targeted-delivery-of-sirnas-to-melanoma-cells-using-a-fusion-peptide-carrier
#14
Renquan Ruan, Ming Chen, Sijie Sun, Pengfei Wei, Lili Zou, Jing Liu, Dayong Gao, Longping Wen, Weiping Ding
Topical application of siRNAs through the skin is a potentially effective strategy for the treatment of melanoma tumors. In this study, we designed a new and safe fusion peptide carrier SPACE-EGF to improve the skin and cell penetration function of the siRNAs and their targeting ability to B16 cells, such that the apoptosis of B16 cells can be induced. The results show that the carrier is stable and less toxic. The EGF motif does not affect the skin and cell penetration function of the SPACE. Because EGF can strongly bind EGFR, which is overexpressed in cancer cells, the targeting ability of the SPACE-EGF-siRNA complex is increased...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27348572/egfr-mutations-in-non-small-cell-lung-cancer-an-audit-from-west-china-hospital
#15
Yuan Tang, Wei-Ya Wang, Ke Zheng, Lili Jiang, Yan Zou, Xue-Ying Su, Jie Chen, Wen-Yan Zhang, Wei-Ping Liu
OBJECTIVES: To discover the incidence and characteristics of EGFR mutations in non-small cell lung cancer (NSCLC) in a single, large cohort as a part of routine diagnostic investigations. METHODS: We reviewed EGFR mutations investigated by Amplification Refractory Mutation System (ARMS) PCR (covering 29 known mutations) using DNA samples from FFPE tissue or cell clot specimens in a total of 3894 cases of NSCLC analysed between 2012-2014. RESULTS: EGFR mutations are preferentially associated with adenocarcinomaand adenosquamous histology, particularly those well to moderately differentiated, and were significantly more common in female than male patients irrespective of histological subtypes...
August 2016: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/27329125/clinical-features-mutations-and-treatment-of-104-patients-of-diamond-blackfan-anemia-in-china-a-single-center-retrospective-study
#16
Yang Wan, Xiaojuan Chen, Wenbin An, Min Ruan, Jingliao Zhang, Lixian Chang, Ranran Zhang, Shuai Zhu, Yingchi Zhang, Wenyu Yang, Ye Guo, Weiping Yuan, Yao Zou, Yumei Chen, Xiaofan Zhu
Diamond-Blackfan anemia (DBA) is an inherited bone marrow failure syndrome characterized by a paucity of erythroid progenitors. We summarized the clinical and genetic features of 104 DBA patients in a single-center retrospective study in China. Data of DBA patients who received consultations at our center from 2003 to 2015 were analyzed retrospectively. Genes encoding 10 ribosomal proteins (RPs) and GATA1 were sequenced for mutation detection. Our cohort was composed of 65 males and 39 females. Congenital malformations were observed in 19 patients...
October 2016: International Journal of Hematology
https://www.readbyqxmd.com/read/27329103/trim11-overexpression-promotes-proliferation-migration-and-invasion-of-lung-cancer-cells
#17
Xiaolin Wang, Weiping Shi, Hongcan Shi, Shichun Lu, Kang Wang, Chao Sun, Jiansheng He, Weiguo Jin, Xiaoxia Lv, Hui Zou, Yusheng Shu
BACKGROUND: Tripartite Motif Containing 11 (TRIM11), a member of TRIM proteins, is overexpressed in high-grade gliomas and plays an oncogenic function in glioma biology. However, little is known about the role of TRIM11 in lung cancer. METHODS: We analyzed TRIM11 mRNA expression in lung cancer tissues and adjacent non-neoplastic tissues by real-time PCR. We then explored the function of TRIM11 in lung cancer cells by small interfering RNA-mediated downregulation of this protein followed by analyses of cell proliferation, migration and invasion...
2016: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/27257063/rna-topoisomerase-is-prevalent-in-all-domains-of-life-and-associates-with-polyribosomes-in-animals
#18
Muzammil Ahmad, Yutong Xue, Seung Kyu Lee, Jennifer L Martindale, Weiping Shen, Wen Li, Sige Zou, Maria Ciaramella, Hélène Debat, Marc Nadal, Fenfei Leng, Hongliang Zhang, Quan Wang, Grace Ee-Lu Siaw, Hengyao Niu, Yves Pommier, Myriam Gorospe, Tao-Shih Hsieh, Yuk-Ching Tse-Dinh, Dongyi Xu, Weidong Wang
DNA Topoisomerases are essential to resolve topological problems during DNA metabolism in all species. However, the prevalence and function of RNA topoisomerases remain uncertain. Here, we show that RNA topoisomerase activity is prevalent in Type IA topoisomerases from bacteria, archaea, and eukarya. Moreover, this activity always requires the conserved Type IA core domains and the same catalytic residue used in DNA topoisomerase reaction; however, it does not absolutely require the non-conserved carboxyl-terminal domain (CTD), which is necessary for relaxation reactions of supercoiled DNA...
July 27, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27234787/regulation-of-plasma-lipid-homeostasis-by-hepatic-lipoprotein-lipase-in-adult-mice
#19
Gan Liu, Jun-Nan Xu, Dong Liu, Qingli Ding, Meng-Na Liu, Rong Chen, Mengdi Fan, Ye Zhang, Chao Zheng, Da-Jin Zou, Jianxin Lyu, Weiping J Zhang
LPL is a pivotal rate-limiting enzyme to catalyze the hydrolysis of TG in circulation, and plays a critical role in regulating lipid metabolism. However, little attention has been paid to LPL in the adult liver due to its relatively low expression. Here we show that endogenous hepatic LPL plays an important physiological role in plasma lipid homeostasis in adult mice. We generated a mouse model with the Lpl gene specifically ablated in hepatocytes with the Cre/LoxP approach, and found that specific deletion of hepatic Lpl resulted in a significant decrease in plasma LPL contents and activity...
July 2016: Journal of Lipid Research
https://www.readbyqxmd.com/read/27197152/myeloid-derived-suppressor-cells-endow-stem-like-qualities-to-breast-cancer-cells-through-il6-stat3-and-no-notch-cross-talk-signaling
#20
Dongjun Peng, Takashi Tanikawa, Wei Li, Lili Zhao, Linda Vatan, Wojciech Szeliga, Shanshan Wan, Shuang Wei, Yin Wang, Yan Liu, Elzbieta Staroslawska, Franciszek Szubstarski, Jacek Rolinski, Ewelina Grywalska, Andrzej Stanisławek, Wojciech Polkowski, Andrzej Kurylcio, Celina Kleer, Alfred E Chang, Max Wicha, Michael Sabel, Weiping Zou, Ilona Kryczek
Myeloid-derived suppressor cells (MDSC) contribute to immune suppression in cancer, but the mechanisms through which they drive metastatic progression are not fully understood. In this study, we show how MDSC convey stem-like qualities to breast cancer cells that coordinately help enable immune suppression and escape. We found that MDSC promoted tumor formation by enhancing breast cancer cell stem-like properties as well as by suppressing T-cell activation. Mechanistic investigations indicated that these effects relied upon cross-talk between the STAT3 and NOTCH pathways in cancer cells, with MDSC inducing IL6-dependent phosphorylation of STAT3 and activating NOTCH through nitric oxide leading to prolonged STAT3 activation...
June 1, 2016: Cancer Research
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