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https://www.readbyqxmd.com/read/28932193/safety-profile-of-anticancer-and-immune-modulating-biotech-drugs-used-in-a-real-world-setting-in-campania-region-italy-bio-cam-observational-study
#1
Cristina Scavone, Liberata Sportiello, Maria G Sullo, Carmen Ferrajolo, Rosanna Ruggiero, Maurizio Sessa, Pasquale M Berrino, Gabriella di Mauro, Liberato Berrino, Francesco Rossi, Concetta Rafaniello, Annalisa Capuano
Objectives: To investigate the occurrence of adverse events (AEs) in naïve patients receiving biotech drugs. Design: A prospective observational study. Setting: Onco-hematology, Hepato-gastroenterology, Rheumatology, Dermatology, and Neurology Units in Campania Region (Italy). Participants: 775 patients (53.81% female) with mean age 56.0 (SD 15.2). The mean follow-up/patient was 3.48 (95% confidence interval 3.13-3.84). Main outcome measures: We collected all AEs associated to biotech drugs, including serious infections and malignancies...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28931861/flexible-bio-memristive-devices-based-on-chicken-egg-albumen-au-sio2-core-shell-nanoparticle-nanocomposites
#2
Chang Han Bok, Sung Jun Woo, Chaoxing Wu, Jae Hyeon Park, Tae Whan Kim
Flexible bio-memristive (FBM) devices utilizing chicken egg albumen (CEA):Au@SiO2 core-shell nanoparticle nanocomposites were fabricated on indium-tin-oxide (ITO) coated polyethylene naphthalate (PEN) substrates. Current-voltage (I-V) curves for the Al/CEA:Au@SiO2 core-shell nanoparticle/ITO/PEN devices showed clockwise current hysteresis behaviors due to the existence of the CEA:Au@SiO2 core-shell nanoparticle nanocomposites. The endurance number of the ON/OFF switching for the FBM devices was above 10(2) cycles...
September 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28929570/impacts-of-human-induced-environmental-change-in-wetlands-on-aquatic-animals
#3
Michael Sievers, Robin Hale, Kirsten M Parris, Stephen E Swearer
Many wetlands harbour highly diverse biological communities and provide extensive ecosystem services; however, these important ecological features are being altered, degraded and destroyed around the world. Despite a wealth of research on how animals respond to anthropogenic changes to natural wetlands and how they use created wetlands, we lack a broad synthesis of these data. While some altered wetlands may provide vital habitat, others could pose a considerable risk to wildlife. This risk will be heightened if such wetlands are ecological traps - preferred habitats that confer lower fitness than another available habitat...
September 19, 2017: Biological Reviews of the Cambridge Philosophical Society
https://www.readbyqxmd.com/read/28929330/development-of-a-rapid-analysis-method-for-bone-resection-margins-for-oral-squamous-cell-carcinoma-by-immunoblotting
#4
Claudia Haase, Bernd Lethaus, Ruth Knüchel-Clarke, Frank Hölzle, Angela Cassataro, Till Braunschweig
The purpose of this proof-of-principle study was to develop a rapid and approachable method to analyse bone resection margins in patients with oral squamous cell carcinoma (OSCC) in an intraoperative setting, similar to assessing frozen sections of soft tissue. Bone excision and risk of remaining tumour cells could be minimised, thus improving reconstruction measures and facilitating convalescence. Frozen, sawed wafers of porcine bone artificially combined with porcine skin (simulating OSCC properties) were used to develop and evaluate a new molecular method: protein transfer from non-decalcified, sawed wafers onto a membrane stained by immunofluorescence (Tissue-ProtTrans)...
September 19, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28926076/electronic-imitation-of-behavioral-and-psychological-synaptic-activities-using-tiox-al2o3-based-memristor-devices
#5
Writam Banerjee, Qi Liu, Hangbing Lv, Shibing Long, Ming Liu
Seeking an effective electronic synapse to emulate biological synaptic behavior is fundamental for building brain-inspired computers. An emerging two-terminal memristor, in which the conductance can be gradually modulated by external electrical stimuli, is widely considered as the strongest competitor of the electronic synapse. Here, we show the capability of TiOx/Al2O3-based memristor devices to imitate synaptic behaviors. Along with analog resistive switching performances, the devices replicate the bio-synapse behaviors of potentiation/depression, short-term-plasticity, and long-term-potentiation, which show that TiOx/Al2O3-based memristors may be useful as electronic synapses...
September 19, 2017: Nanoscale
https://www.readbyqxmd.com/read/28922165/the-gastrointestinal-brain-axis-in-humans-as-an-evolutionary-advance-of-the-root-leaf-axis-in-plants-a-hypothesis-linking-quantum-effects-of-light-on-serotonin-and-auxin
#6
Lucio Tonello, Bekim Gashi, Alessandro Scuotto, Glenda Capello, Massimo Cocchi, Fabio Gabrielli, Jack A Tuszynski
Living organisms tend to find viable strategies under ambient conditions that optimize their search for, and utilization of, life-sustaining resources. For plants, a leading role in this process is performed by auxin, a plant hormone that drives morphological development, dynamics, and movement to optimize the absorption of light (through branches and leaves) and chemical "food" (through roots). Similarly to auxin in plants, serotonin seems to play an important role in higher animals, especially humans. Here, it is proposed that morphological and functional similarities between (i) plant leaves and the animal/human brain and (ii) plant roots and the animal/human gastro-intestinal tract have general features in common...
September 15, 2017: Journal of Integrative Neuroscience
https://www.readbyqxmd.com/read/28918489/yersinia-enterocolitica-biotype-1a-a-possible-new-trigger-of-reactive-arthritis
#7
Riitta Tuompo, Timo Hannu, Elisa Huovinen, Leila Sihvonen, Anja Siitonen, Marjatta Leirisalo-Repo
Yersinia enterocolitica (YE) biotype 1A is generally considered non-pathogenic, and the role of it in causing reactive musculoskeletal complications is unclear. We evaluated the capability of YE biotype 1A to induce reactive arthritis (ReA) and other reactive musculoskeletal symptoms. Analysis of self-reported musculoskeletal symptoms was supplemented with a telephone interview (with a permission to acquire copies of patient files from a local physician or hospital) and/or clinical examination of subjects with recent musculoskeletal symptoms after a positive stool culture for YE...
September 16, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28910854/characterizing-the-nano-bio-interface-using-microscopic-techniques-imaging-the-cell-system-is-just-as-important-as-imaging-the-nanoparticle-system
#8
Christie M Sayes, Henry Lujan
The rapid growth of nanotechnology and its industries has elevated the need to understand the risks associated with handling, using, and disposing of nanomaterials. These risks can be assessed through exposure measurement and hazard identification. One of the common challenges associated with quantifying nanomaterials in products, waste, humans, or the environment is the lack of tools available to measure concentration. The ability of refined tools and techniques to qualitatively detect nanoparticles in complex matrices has been demonstrated...
September 14, 2017: Current Protocols in Chemical Biology
https://www.readbyqxmd.com/read/28903544/the-process-defines-the-product-what-really-matters-in-biosimilar-design-and-production
#9
Arnold G Vulto, Orlando A Jaquez
Biologic drugs are highly complex molecules produced by living cells through a multistep manufacturing process. The key characteristics of these molecules, known as critical quality attributes (CQAs), can vary based on post-translational modifications that occur in the cellular environment or during the manufacturing process. The extent of the variation in each of the CQAs must be characterized for the originator molecule and systematically matched as closely as possible by the biosimilar developer to ensure bio-similarity...
August 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/28894860/elastic-and-viscous-bond-components-in-the-adhesion-of-colloidal-particles-and-fibrillated-streptococci-to-qcm-d-crystal-surfaces-with-different-hydrophobicities-using-kelvin-voigt-and-maxwell-models
#10
Rebecca van der Westen, Prashant K Sharma, Hans De Raedt, Ijsbrand Vermue, Henny C van der Mei, Henk J Busscher
A quartz-crystal-microbalance with dissipation (QCM-D) can measure molecular mass adsorption as well as register adhesion of colloidal particles. However, analysis of the QCM-D output to quantitatively analyze adhesion of (bio)colloids to obtain viscoelastic bond properties is still a subject of debate. Here, we analyze the QCM-D output to analyze the bond between two hydrophilic streptococcal strains 91 nm long and without fibrillar surface appendages and micron-sized hydrophobic polystyrene particles on QCM-D crystal surfaces with different hydrophobicities, using the Kelvin-Voigt model and the Maxwell model...
September 12, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28890874/usefulness-of-amino-terminal-pro-b-type-natriuretic-peptide-in-evaluating-children-with-cardiac-failure
#11
Isoken A Isah, Wilson E Sadoh, Nosakhare J Iduoriyekemwen
BACKGROUND: The plasma levels of amino terminal pro-B type natriuretic peptide (NT-proBNP) have been found to be useful in evaluating children with heart failure in developed countries where the cause is mainly structural heart lesions. There is paucity of similar studies from developing countries where the causes are mostly of infectious origin. This article is aim to evaluate the relationship between plasma NT-proBNP levels and the severity, outcome and duration of admission of children with heart failure...
August 2017: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/28890259/silk-fibroin-chondroitin-sulfate-scaffold-with-immuno-inhibition-property-for-articular-cartilage-repair
#12
Feifei Zhou, Xianzhu Zhang, Dandan Cai, Jun Li, Qin Mu, Wei Zhang, Shouan Zhu, Yangzi Jiang, Weiliang Shen, Shufang Zhang, Hong Wei Ouyang
The demand of favorable scaffolds has increased for the emerging cartilage tissue engineering. Chondroitin sulfate (CS) and silk fibroin have been investigated and reported with safety and excellent biocompatibility as tissue engineering scaffolds. However, the rapid degradation rate of pure CS scaffolds presents a challenge to effectively recreate neo-tissue similar to natural articular cartilage. Meanwhile the silk fibroin is well used as a structural constituent material because its remarkable mechanical properties, long-lasting in vivo stability and hypoimmunity...
September 7, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28888543/preparation-and-characterization-of-bio-nanocomposite-films-based-on-cassava-starch-or-chitosan-reinforced-with-montmorillonite-or-bamboo-nanofibers
#13
Jaiber H R Llanos, Carmen C Tadini
In this study, films based on two different polysaccharides (chitosan and cassava starch) were produced by casting technique and nanostructured by montmorillonite (MMTNPs) or bamboo nanofibers (BNFs) at two different concentrations: 0.5g/100g and 1.0g/100g of polymer, using glycerol as plasticizer at concentration of 30g/100g of polymer. The particle size and surface charge of the MMTNPs and BNFs nanoparticles were 315±14nm and 60±3nm and -31.78mV and -20.77mV, respectively. In relation to the mechanical properties, the nanofibers increased the tensile strength in 50% of starch films, while the elongation at break shows a similar increase (66%) for both types of nanoparticles at concentration of 1...
September 6, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28887733/computational-design-of-bio-inspired-carnosine-based-hobr-antioxidants
#14
Farzaneh Sarrami, Li-Juan Yu, Amir Karton
During a respiratory burst the enzyme myeloperoxidase generates significant amounts of hypohalous acids (HOX, X = Cl and Br) in order to inflict oxidative damage upon invading pathogens. However, excessive production of these potent oxidants is associated with numerous inflammatory diseases. It has been suggested that the endogenous antioxidant carnosine is an effective HOCl scavenger. Recent computational and experimental studies suggested that an intramolecular Cl(+) transfer from the imidazole ring to the terminal amine might play an important role in the antioxidant activity of carnosine...
September 8, 2017: Journal of Computer-aided Molecular Design
https://www.readbyqxmd.com/read/28878698/synthetic-cathinone-and-cannabinoid-designer-drugs-pose-a-major-risk-for-public-health
#15
REVIEW
Aviv M Weinstein, Paola Rosca, Liana Fattore, Edythe D London
As part of an increasing worldwide use of designer drugs, recent use of compounds containing cathinones and synthetic cannabinoids is especially prevalent. Here, we reviewed current literature on the prevalence, epidemiology, bio-behavioral effects, and detection of these compounds. Gender differences and clinical effects will also be examined. Chronic use of synthetic cathinone compounds can have major effects on the central nervous system and can induce acute psychosis, hypomania, paranoid ideation, and delusions, similar to the effects of other better-known amphetamine-type stimulants...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28877275/evaluation-of-physicochemical-properties-of-root-end-filling-materials-using-conventional-and-micro-ct-tests
#16
Fernanda Ferrari Esteves Torres, Roberta Bosso-Martelo, Camila Galletti Espir, Joni Augusto Cirelli, Juliane Maria Guerreiro-Tanomaru, Mario Tanomaru-Filho
Objective: To evaluate solubility, dimensional stability, filling ability and volumetric change of root-end filling materials using conventional tests and new Micro-CT-based methods. Material and Methods: 7. Results: The results suggested correlated or complementary data between the proposed tests. At 7 days, BIO showed higher solubility and at 30 days, showed higher volumetric change in comparison with MTA (p<0.05). With regard to volumetric change, the tested materials were similar (p>0...
July 2017: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/28866413/nano-structural-comparison-of-2-methacryloyloxyethyl-phosphorylcholine-and-ethylene-glycol-based-surface-modification-for-preventing-protein-and-cell-adhesion
#17
Tomoyuki Azuma, Ryuichi Ohmori, Yuji Teramura, Takahiro Ishizaki, Madoka Takai
Polymer brush, owing to its precisely controllable nanostructure, has great potential for surface modification in the biomedical field. In this study, we evaluated the bio-inertness of polymer brush, monomer monolayers, and polymer-coated surfaces based on their structures, to identify the most effective bio-inert modification. We focused on two well-known bio-inert materials, 2-methacryloyloxyethyl phosphorylcholine (MPC) and ethylene glycol (EG). The amount of adsorbed proteins on the surface was found to be dependent on the monomer unit density in the case of MPC, whereas this correlation was not observed in the case of EG...
August 26, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28852760/an-aptamer-bio-barcode-abc-assay-using-spr-rnase-h-and-probes-with-rna-and-gold-nanorods-for-anti-cancer-drug-screening
#18
Jacky Fong-Chuen Loo, Chengbin Yang, Hing Lun Tsang, Pui Man Lau, Ken-Tye Yong, Ho Pui Ho, Siu Kai Kong
With modifications to an ultra-sensitive bio-barcode (BBC) assay, we have developed a next generation aptamer-based bio-barcode (ABC) assay to detect cytochrome-c (Cyto-c), a cell death marker released from cancer cells, for anti-cancer drug screening. An aptamer is a short single-stranded DNA selected from a synthetic DNA library that is capable of binding to its target with high affinity and specificity based on its unique DNA sequence and 3D structure after folding. Similar to the BBC assay, Cyto-c is captured by a micro-magnetic particle (MMP) coated with capturing antibodies (Ab) and an aptamer specifically against Cyto-c to form sandwich structures ([MMP-Ab]-[Cyto-c]-[Aptamer])...
August 30, 2017: Analyst
https://www.readbyqxmd.com/read/28852205/probiotics-administration-following-sleeve-gastrectomy-surgery-a-randomized-double-blind-trial
#19
S Sherf-Dagan, S Zelber-Sagi, G Zilberman-Schapira, M Webb, A Buch, A Keidar, A Raziel, N Sakran, D Goitein, N Goldenberg, J A Mahdi, M Pevsner-Fischer, N Zmora, M Dori-Bachash, E Segal, E Elinav, O Shibolet
BACKGROUND: Probiotics are commonly used after bariatric surgery; however uncertainty remains regarding their efficacy. Our aim was to compare the effect of probiotics vs. placebo on hepatic, inflammatory and clinical outcomes following laparoscopic sleeve gastrectomy (LSG). METHODS: This randomized, double-blind, placebo-controlled, trial of 6-months treatment with probiotics (Bio-25;Supherb) vs. placebo and 6-months of additional follow-up was conducted among 100 morbidly obese non-alcoholic fatty liver disease (NAFLD) patients who underwent LSG surgery...
August 30, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28846134/mineral-trioxide-aggregate-and-other-bioactive-endodontic-cements-an-updated-overview-part-ii-other-clinical-applications-and-complications
#20
REVIEW
M Torabinejad, M Parirokh, P M H Dummer
Mineral trioxide aggregate (MTA) is a dental material used extensively for vital pulp therapy (VPT), scaffold cover during regenerative endodontic procedures, apical barrier in teeth with necrotic pulps and open apices, perforation repair, and root canal filling and root-end filling during surgical endodontics. A number of bioactive endodontic cements (BECs) have recently been introduced to the market. Most of these materials had calcium and silicate in their compositions; however, the bioactivity is the common property of these cements...
August 28, 2017: International Endodontic Journal
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