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https://www.readbyqxmd.com/read/29147713/variation-of-the-bone-forming-ability-with-the-physicochemical-properties-of-calcium-phosphate-bone-substitutes
#1
Rongquan Duan, Davide Barbieri, Xiaoman Luo, Jie Weng, Chongyun Bao, Joost D de Bruijn, Huipin Yuan
Because of their bioactive properties and chemical similarity to the inorganic component of bone, calcium phosphate (CaP) materials are widely used for bone regeneration. Six commercially available CaP bone substitutes (Bio-Oss, Actifuse, Bi-Ostetic, MBCP, Vitoss and chronOs) as well as two tricalcium phosphate (TCP) ceramics with either a micron-scale (TCP-B) or submicron-scale (TCP-S) surface structure are characterized and their bone forming potential is evaluated in a canine ectopic implantation model. After 12 weeks of implantation in the paraspinal muscle of four beagles, sporadic bone (0...
November 17, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/29136371/designing-dendron-polymer-conjugate-based-targeted-drug-delivery-platforms-with-a-mix-and-match-modularity
#2
Burcu Sumer Bolu, Bianka Golba, Nazli Boke, Amitav Sanyal, Rana Sanyal
Polymeric micellar systems are emerging as a very important class of nano-pharmaceuticals due to their ability to improve pharmacokinetics and bio-distribution of chemotherapy drugs, as well as to reduce related systemic toxicities. While these nano sized delivery systems inherently benefit from passive targeting through the enhanced permeation and retention effect leading to increased accumulation in the tumor, additional active targeting can be achieved through surface modification of micelles with targeting groups specific for over-expressed receptors of tumor cells...
November 14, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29131062/cardio-renal-determinants-of-erectile-dysfunction-in-primary-prevention-a-cross-sectional-study
#3
Vilma Dzenkeviciute, Zaneta Petrulioniene, Egidija Rinkuniene, Virginijus Sapoka, Marija Petrylaite, Jolita Badariene
OBJECTIVE: To investigate the association between severity of erectile dysfunction, cardiovascular risk and target organ (heart, renal, vascular) damage in men free of cardiovascular diseases (CV). SUBJECTS AND METHODS: This study included 182 men: 100 with erectile dysfunction (ED) (IIEF mean score ≤ 21) and 82 without ED (IIEF mean score > 21). The ED was assessed using the International Index of Erectile Function (IIEF-5). Ultrasound was used to evaluate carotid plaques and left ventricular mass, geometry and diastolic function...
November 5, 2017: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/29129379/children-with-epilepsy-against-their-healthy-peers-and-those-with-headaches-differences-similarities
#4
Dorota Talarska, Michał Michalak, Patrycja Talarska, Barbara Steinborn
INTRODUCTION: Epilepsy, like most chronic diseases, affects bio-psycho-social functioning of children and adolescents. The aim of this work was to assess functioning of children with epilepsy compared with the group of healthy children and those with headaches carried out by children themselves and their mothers. MATERIAL AND METHODS: The study included 209 children with epilepsy and 173 children with headaches and 182 healthy students and their mothers. The research tool was Pediatric Quality of Life Inventory 4...
October 27, 2017: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/29127041/logical-comparison-over-rdf-resources-in-bio-informatics
#5
S Colucci, F M Donini, E Di Sciascio
Comparison of resources is a frequent task in different bio-informatics applications, including drug-target interaction, drug repositioning and mechanism of action understanding, among others. This paper proposes a general method for the logical comparison of resources modeled in Resource Description Framework and shows its distinguishing features with reference to the comparison of drugs. In particular, the method returns a description of the commonalities between resources, rather than a numerical value estimating their similarity and/or relatedness...
November 7, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/29122711/developmental-refinement-of-synaptic-transmission-on-micropatterned-single-layer-graphene
#6
Sandeep Keshavan, Shovan Naskar, Alberto Diaspro, Laura Cancedda, Silvia Dante
Interfacing neurons with a single atomic layer of graphene, single atomic layer of sp2 hybridized C-atoms, is a key paradigm in understanding how to exploit the unique properties of such a two-dimensional system for neural prosthetics and biosensors development. In order to fabricate graphene-based circuitry, a reliable large area patterning method is a requirement. Following a previously developed protocol, we monitored the in vitro neuronal development of geometrically ordered neural network growing onto patterned Single Layer Graphene (SLG) coated with poly-D-lysine...
November 6, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29120767/observations-using-phosphorus-31-nuclear-magnetic-resonance-31-p-nmr-of-structural-changes-in-freeze-thawed-hen-egg-yolk
#7
Hiroki Wakamatsu, Akihiro Handa, Kazuhiro Chiba
Hen egg yolk (EY) has a complicated structure consisting of lipids and proteins, and its structure is deeply related with its functional properties. (31)P-NMR is an efficient technique to non-destructively detect the dynamic behaviour of phospholipids, the main component of bio-membranes. We determined conditions for measuring the (31)P NMR spectra of EY and identified the components. (31)P-NMR was used to detect phosvitin, inorganic phosphate, and lipoprotein as well as structural changes such as granule collapse and freeze-thaw denaturation as signal changes...
April 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29110730/a-meta-science-for-a-global-bioethics-and-biomedicine
#8
David S Basser
BACKGROUND: As suggested by Shook and Giordano, understanding and therefore addressing the urgent international governance issues around globalizing bio-medical/technology research and applications is limited by the perception of the underlying science. METHODS: A philosophical methodology is used, based on novel and classical philosophical reflection upon existent literature, clinical wisdoms and narrative theory to discover a meta-science and telos of humankind for the development of a relevant and defendable global biomedical bioethics...
November 7, 2017: Philosophy, Ethics, and Humanities in Medicine: PEHM
https://www.readbyqxmd.com/read/29107054/selecting-the-correct-cellular-model-for-assessing-of-the-biological-response-of-collagen-based-biomaterials
#9
Natalia Davidenko, Samir Hamaia, Daniel V Bax, Jean-Daniel Malcor, Carlos F Schuster, Donald Gullberg, Richard W Farndale, Serena M Best, Ruth E Cameron
Accurate evaluation of the biological performance of biomaterials requires the correct assessment of their native-like cell ligation properties. However, cell attachment studies often overlook the details of the substrate-cell binding mechanisms, be they integrin-mediated or non-specific, and ignore the class- and species-specificities of the cell adhesion receptor involved. In this work we have used different collagen (Col) substrates (fibrillar collagens I, II and III and network-forming Col IV), containing different affinity cell-recognition motifs, to establish the influence of the receptor identity and species-specificity on collagen-cell interactive properties...
October 26, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29106909/a-study-of-bio-hybrid-silsesquioxane-yeast-biosorption-and-neuronal-toxicity-of-lead
#10
Bianca Trama-Freitas, Johnattan C S Freitas, Rui C Martins, Licínio M Gando-Ferreira, Maria Emília Quinta-Ferreira, Rosa Maria Quinta-Ferreira, Devaney R do Carmo
Lead is a heavy metal of high impact for the environment as well as for human health, being cause of several diseases. Considering the importance of obtaining an effective treatment for lead removal, a new hybrid material was developed for sorption of Pb(2+) from aqueous solution. The effect of pH, temperature, liquid/solid ratio (g/cm(3)) and lead concentration on the sorption capacity of yeasts chemically modified with cubic silsesquioxane (YS) was analyzed. Additionally, the toxicity of lead on the neuronal activity was also investigated in order to assess whether the damage caused by the Pb(2+) ion is reversible or not...
October 26, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/29102891/mechanism-of-tribofilm-formation-on-ti6al4v-oxygen-diffusion-layer-in-a-simulated-body-fluid
#11
R Yazdi, H M Ghasemi, M Abedini, C Wang, A Neville
An Oxygen Diffusion Layer (ODL) was generated on the surface of Ti6Al4V alloy by thermal oxidation treatment. In vitro tests for cytotoxicity were performed in the presence of Ti6Al4V and the ODL samples with the culture of G292 Cells using MTT assay. The results showed a similar cell viability in the presence of the both samples. Wear behaviour of Ti6Al4V and the ODL samples was investigated in a phosphate buffered saline solution under a normal load of 30N at a sliding velocity of 0.1m/s. The worn surface and subsurface of the samples were studied using SEM, STEM, TEM, XPS, AFM, nano-hardness and surface profilometry...
October 18, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29102193/fluorescent-tracers-to-evaluate-pesticide-dissipation-and-transformation-in-agricultural-soils
#12
Jens Lange, Oliver Olsson, Brian Sweeney, Barbara Herbstritt, Marco Reich, Pablo Alvarez-Zaldivar, Sylvain Payraudeau, Gwenaël Imfeld
This study evaluates the mobility and dissipation of two organic fluorescent tracers (uranine, UR and sulforhodamine-B, SRB) in soil from an agricultural field. Two plot experiments were conducted for 2.5months in 2012 and 2016 to compare the behavior of reactive fluorescent tracers (UR and SRB) to the chloroacetanilide herbicide S-metolachlor (S-MET) and bromide (BR), used as a traditional conservative tracer. SRB in top soil closely mimicked the gradual recession of S-MET, while BR overrated both top soil mobility and slow leaching of S-MET in the soil column...
October 25, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29101870/enhanced-biological-properties-of-biomimetic-apatite-fabricated-polycaprolactone-chitosan-nanofibrous-bio-composite-for-tendon-and-ligament-regeneration
#13
Geng Wu, Xuefeng Deng, Jinqi Song, Feiqiang Chen
The development of tailored nanofibrous scaffolds for tendon and ligament tissue engineering has been a goal of clinical research for current researchers. Here, we establish a formation of novel nanofibrous matrix with significant mechanical and biological properties by electro-spinning process. The fine fibrous morphology of the nanostructured hydroxyapatite (HAp) dispersed in the polycaprolactone/chitosan (HAp-PCL/CS) nanofibrous matrix was exhibited by microscopic (SEM and TEM) techniques. The favorable mechanical properties (load and modulus) were achieved...
October 7, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29101602/garcinia-mangostana-linn-displays-antidepressant-like-and-pro-cognitive-effects-in-a-genetic-animal-model-of-depression-a-bio-behavioral-study-in-the-flinders-sensitive-line-rat
#14
Inge Oberholzer, Marisa Möller, Brendan Holland, Olivia M Dean, Michael Berk, Brian H Harvey
There is abundant evidence for both disorganized redox balance and cognitive deficits in major depressive disorder (MDD). Garcinia mangostana Linn (GM) has anti-oxidant activity. We studied the antidepressant-like and pro-cognitive effects of raw GM rind in Flinders Sensitive Line (FSL) rats, a genetic model of depression, following acute and chronic treatment compared to a reference antidepressant, imipramine (IMI). The chemical composition of the GM extract was analysed for levels of α- and γ-mangostin...
November 3, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29100829/prospective-and-randomized-evaluation-of-chronos-and-bio-oss-in-human-maxillary-sinuses-histomorphometric-and-immunohistochemical-assignment-for-runx-2-vascular-endothelial-growth-factor-and-osteocalcin
#15
João Paulo Bonardi, Rodrigo Dos Santos Pereira, Fernanda Brasil Jorge Daura Boos, Leonarod Perez Faverani, Geraldo Luiz Griza, Roberta Okamoto, Eduardo Hochuli-Vieira
PURPOSE: The aim of this study was to compare ChronOS (β-tricalcium phosphate), Bio-Oss, and their addition to an autogenous bone graft in a 1:1 ratio in human maxillary sinus bone augmentation. MATERIALS AND METHODS: Thirty maxillary sinuses were divided in 5 groups: group 1 included 6 maxillary sinuses grafted with autogenous bone graft alone; group 2 included 6 maxillary sinuses grafted with ChronOS; group 3 included 6 maxillary sinuses grafted with ChronOS and autogenous bone graft in a 1:1 ratio; group 4 included 6 maxillary sinuses grafted with Bio-Oss; and group 5 included 6 maxillary sinuses grafted with Bio-Oss and autogenous bone graft in a 1:1 ratio...
October 10, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29097870/adipose-derived-stromal-cells-resemble-bone-marrow-stromal-cells-in-hepatocyte-differentiation-potential-in-vitro-and-in-vivo
#16
Li-Juan Xu, Shu-Fang Wang, De-Qing Wang, Lian-Jun Ma, Zheng Chen, Qian-Qian Chen, Jun Wang, Li Yan
AIM: To investigate whether mesenchymal stem cells (MSCs) from adipose-derived stromal cells (ADSCs) and bone marrow stromal cells (BMSCs) have similar hepatic differentiation potential. METHODS: Mouse ADSCs and BMSCs were isolated and cultured. Their morphological and phenotypic characteristics, as well as their multiple differentiation capacity were compared. A new culture system was established to induce ADSCs and BMSCs into functional hepatocytes. Reverse transcription polymerase chain reaction, Western blot, and immunofluorescence analyses were performed to identify the induced hepatocyte-like cells...
October 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29096382/a-novel-approach-for-dimension-reduction-of-microarray
#17
Rabia Aziz, C K Verma, Namita Srivastava
This paper proposes a new hybrid search technique for feature (gene) selection (FS) using Independent component analysis (ICA) and Artificial Bee Colony (ABC) called ICA+ABC, to select informative genes based on a Naïve Bayes (NB) algorithm. An important trait of this technique is the optimization of ICA feature vector using ABC. ICA+ABC is a hybrid search algorithm that combines the benefits of extraction approach, to reduce the size of data and wrapper approach, to optimize the reduced feature vectors. This hybrid search technique is facilitated by evaluating the performance of ICA+ABC on six standard gene expression datasets of classification...
October 28, 2017: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/29096313/regulation-of-pregnane-x-receptor-and-micrornas-on-detoxification-related-genes-expressions-in-mugilogobius-abei-under-the-exposure-to-diclofenac
#18
Peijia Ku, Chao Wang, Xiangping Nie, Ruikang Ou, Kaibing Li
Diclofenac (DCF) has been recognized as an emerging contaminant in aquatic environments. Though many studies have investigated the toxic effects of DCF in human and mammals, limited information is available for the responses of genes associated with detoxification metabolisms in non-target aquatic organisms such as fish. In the present study, a small benthic fish Mugilogobius abei, was chosen as the test organism and the effects of DCF on detoxification-related genes at transcriptional level in M. abei were investigated...
October 30, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29094469/afm-and-nanoindentation-investigation-of-pdms-elastomeric-substrate-compliancy-for-various-sputtered-thin-film-morphologies
#19
Debashis Maji, Soumen Das
Crack free electrically continuous metal thin films over soft elastomeric substrates play an integral part in realization of modern day flexible bio-electronics and biosensors. Under non-optimized deposition conditions, delamination and/or cracking of the top film as well as the underlying soft substrate hinders optimal performance of these devices. Hence it is very important to understand and control not only the various deposition factors like power, time or deposition pressure but also investigate the various interfacial physics playing a critical role in assuring thin film adhesion and substrate compliancy...
November 1, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29093304/baseline-profile-of-participants-in-the-japan-environment-and-children-s-study-jecs
#20
Takehiro Michikawa, Hiroshi Nitta, Shoji F Nakayama, Shin Yamazaki, Tomohiko Isobe, Kenji Tamura, Eiko Suda, Masaji Ono, Junzo Yonemoto, Miyuki Iwai-Shimada, Yayoi Kobayashi, Go Suzuki, Toshihiro Kawamoto
BACKGROUND: The Japan Environment and Children's Study (JECS), known as Ecochil-Chosa in Japan, is a nationwide birth cohort study investigating the environmental factors that might affect children's health and development. We report the baseline profiles of the participating mothers, fathers, and their children. METHODS: Fifteen Regional Centres located throughout Japan were responsible for recruiting women in early pregnancy living in their respective recruitment areas...
October 25, 2017: Journal of Epidemiology
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