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https://www.readbyqxmd.com/read/28100051/basement-membrane-mimics-of-biofunctionalized-nanofibers-for-a-bipolar-cultured-human-primary-alveolar-capillary-barrier-model
#1
Akihiro Nishiguchi, Smriti Singh, Matthias Wessling, Charles James Kirkpatrick, Martin Moeller
In vitro reconstruction of an alveolar barrier for modeling normal lung functions and pathological events serve as reproducible, high-throughput pharmaceutical platforms for drug discovery, diagnosis, and regenerative medicine. Despite much effort, the reconstruction of organ-level alveolar barrier functions has failed due to the lack of structural similarity to the natural basement membrane, functionalization with specific ligands for alveolar cell function, the use of primary cells and biodegradability. Here we report a bipolar cultured alveolar-capillary barrier model of human primary cells supported by a basement membrane mimics of fully-synthetic bifunctional nanofibers...
January 18, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28093062/derivation-of-economic-values-for-production-traits-in-aquaculture-species
#2
Kasper Janssen, Paul Berentsen, Mathieu Besson, Hans Komen
BACKGROUND: In breeding programs for aquaculture species, breeding goal traits are often weighted based on the desired gains but economic gain would be higher if economic values were used instead. The objectives of this study were: (1) to develop a bio-economic model to derive economic values for aquaculture species, (2) to apply the model to determine the economic importance and economic values of traits in a case-study on gilthead seabream, and (3) to validate the model by comparison with a profit equation for a simplified production system...
January 5, 2017: Genetics, Selection, Evolution: GSE
https://www.readbyqxmd.com/read/28091436/acute-kidney-injury-in-lagos-pattern-outcomes-and-predictors-of-in-hospital-mortality
#3
B T Bello, A A Busari, C O Amira, Y R Raji, R W Braimoh
CONTEXT: The pattern of acute kidney injury (AKI) differs significantly between developed and developing countries. AIMS: The aim of th study was to determine the pattern and clinical outcomes of AKI in Lagos, Southwest Nigeria. SETTINGS AND DESIGN: A retrospective review of hospital records of all patients with a diagnosis of AKI over a 20-month period. SUBJECTS AND METHODS: Records of 54 patients were reviewed. Information retrieved included, bio-data, etiology of AKI, results of laboratory investigations, and patient outcomes...
February 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/28079128/parallel-meta-3-comprehensive-taxonomical-and-functional-analysis-platform-for-efficient-comparison-of-microbial-communities
#4
Gongchao Jing, Zheng Sun, Honglei Wang, Yanhai Gong, Shi Huang, Kang Ning, Jian Xu, Xiaoquan Su
The number of metagenomes is increasing rapidly. However, current methods for metagenomic analysis are limited by their capability for in-depth data mining among a large number of microbiome each of which carries a complex community structure. Moreover, the complexity of configuring and operating computational pipeline also hinders efficient data processing for the end users. In this work we introduce Parallel-META 3, a comprehensive and fully automatic computational toolkit for rapid data mining among metagenomic datasets, with advanced features including 16S rRNA extraction for shotgun sequences, 16S rRNA copy number calibration, 16S rRNA based functional prediction, diversity statistics, bio-marker selection, interaction network construction, vector-graph-based visualization and parallel computing...
January 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28076307/evaluation-of-the-greiner-bio-one-serum-separator-bca-fast-clot-tube
#5
Goce Dimeski, Julie Johnston, Paul P Masci, Kong-Nan Zhao, Nigel Brown
BACKGROUND: Current commercial tubes have difficulties in producing "true" serum from all blood samples even within the recommended clotting times. Hence, Becton Dickinson (BD) and now Greiner have produced tubes containing thrombin as the procoagulant to reduce the clotting time and increase the possibility of producing serum from anticoagulated blood samples. METHODS: The Greiner BCA Fast Clot (GBBCAFC) tube was evaluated in a hospital environment using 40 participants, (30 healthy and 10 undergoing renal dialysis) for 32 analytes against the Greiner lithium heparin tube and the BD Rapid Serum Tubes (BD RST) tube measured on Beckman DxC 800 and DxI 800 analyzers...
January 11, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28069508/bio-inspired-virus-imprinted-polymer-for-prevention-of-viral-infections
#6
Ning Li, Yan-Jie Liu, Fei Liu, Mi-Fang Luo, Ying-Chun Wan, Zheng Huang, Qiang Liao, Fang-Sheng Mei, Zhi-Cheng Wang, Ai-Yin Jin, Yun Shi, Bin Lu
: A novel virus-imprinted polymer for prevention of viral infection was prepared by anchoring molecularly imprinted polymer (MIP) on the surface of poly-dopamine (PDA)-coated silica particles. The imprinting reaction was carried out via self-polymerization of dopamine in the presence of a virus template. Plaque forming assay indicated that the MIP exhibited selective anti-viral infection properties for the template virus in complex media containing different interfering substances, and even other types of viruses...
January 6, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28069498/poly-glycerol-sebacate-poly-%C3%AE%C2%B5-caprolactone-blend-nanofibrous-scaffold-as-intrinsic-bio-and-immunocompatible-system-for-corneal-repair
#7
Sahar Salehi, Marta Czugala, Piotr Stafiej, Mohammadhossein Fathi, Thomas Bahners, Jochen S Gutmann, Bernhard B Singer, Thomas A Fuchsluger
: A major challenge in corneal tissue engineering and lamellar corneal transplantation is to develop synthetic scaffolds able to simulate the optical and mechanical properties of the native cornea. As a carrier, the graft scaffolds should provide the basis for anchorage, repair and regeneration. Although quite a number of scaffolds have been engineered to date, they have not been able to simultaneously recapitulate chemical, mechanical, and structural properties of the corneal extracellular matrix (ECM)...
January 6, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28068580/bioavailability-and-health-risk-of-some-potentially-toxic-elements-cd-cu-pb-and-zn-in-street-dust-of-asansol-india
#8
Manash Gope, Reginald Ebhin Masto, Joshy George, Raza Rafiqul Hoque, Srinivasan Balachandran
Street dust samples were collected from five different types of land use patterns (busy traffic zone, urban residential area, national highways, industrial area and sensitive area) in a medium sized industrial city Asansol, India. The samples were fractionated into ≤53µm and analyzed for potential toxic elements (PTEs) viz. Zn, Cd, Pb and Cu. The mean total concentration of Zn, Cd, Pb and Cu in the urban street dust samples were 192, 0.75, 110 and 132mgkg(-1) respectively. Chemical speciation was performed for PTEs to evaluate the bio-available fractions...
January 6, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28064437/clinical-pharmacology-research-internships-at-the-interface-of-academia-and-industry-students-perceptions-and-scientific-output
#9
Sebastiaan C Goulooze, Kari L Franson, Adam F Cohen, Robert Rissmann
The Centre for Human Drug Research (CHDR) is a non-profit clinical research institute at the interface between academia and the pharmaceutical industry. CHDR hosts a research internship program for undergraduate (bio)medical students. The aim of this study was i) to investigate the student perceptions of the undergraduate research internship ii) quantify the scientific output related to these internships. We surveyed former interns at the CHDR from the years 2007 - 2014 and quantified their scientific output with a PubMed search...
January 8, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28063146/pretreatment-optimization-of-the-biomass-of-microcystis-aeruginosa-for-efficient-bioethanol-production
#10
Muhammad Imran Khan, Moon Geon Lee, Jin Hyuk Shin, Jong Deog Kim
Microalgae are considered to be the future promising sources of biofuels and bio products. The algal carbohydrates can be fermented to bioethanol after pretreatment process. Efficient pretreatment of the biomass is one of the major requirements for commercialization of the algal based biofuels. In present study the microalga, M. aeruginsa was used for pretreatment optimization and bioethanol production. Treatment of algal biomass with CaO before acid and/or enzymatic hydrolysis enhanced the degradation of algal cells...
December 2017: AMB Express
https://www.readbyqxmd.com/read/28061812/improving-the-production-of-acetyl-coa-derived-chemicals-in-escherichia-coli-bl21-de3-through-iclr-and-arca-deletion
#11
Min Liu, Yamei Ding, Hailin Chen, Zhe Zhao, Huizhou Liu, Mo Xian, Guang Zhao
BACKGROUND: Acetyl-CoA-derived chemicals are suitable for multiple applications in many industries. The bio-production of these chemicals has become imperative owing to the economic and environmental problems. However, acetate overflow is the major drawback for acetyl-CoA-derived chemicals production. Approaches for overcoming acetate overflow may be beneficial for the production of acetyl-CoA-derived chemicals. RESULTS: In this study, a transcriptional regulator iclR was knocked out in E...
January 7, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28054065/the-evaluation-of-5-amino-and-5-hydroxyuracil-derivatives-as-potential-quadruplex-forming-agents
#12
Gábor Paragi, Zoltán Kupihár, Gábor Endre, Célia Fonseca Guerra, Lajos Kovács
5-Substituted uracils (NH2 or OH groups in position 5) have been examined theoretically and experimentally as potential building blocks in quadruplex structures. Our high level Density Functional Theory (DFT) calculations showed that the tetramer formation and stacking energies for 5-substituted uracils are similar to the energies of purine-based xanthine (X) or guanine (G) structures. As tetrads of 5-substituted uracils cover almost exactly the same area as purine tetrads, mixed tetrads or quadruplex structures based on X or G and 5-substituted uracil motifs are possible...
January 5, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28051843/enzyme-triggered-defined-protein-nanoarrays-efficient-light-harvesting-systems-to-mimic-chloroplasts
#13
Linlu Zhao, Haoyang Zou, Hao Zhang, Hongcheng Sun, Tingting Wang, Tiezheng Pan, Xiumei Li, Yushi Bai, Shanpeng Qiao, Quan Luo, Jiayun Xu, Chunxi Hou, Junqiu Liu
The elegance and efficiency by which chloroplasts harvest solar energy and conduct energy transfer have been a source of inspiration for chemists to mimic such process. However, precise manipulation to obtain orderly arranged antenna chromophores in constructing artificial chloroplast mimics was a great challenge, especially from the structural similarity and bioaffinity standpoints. Here we reported a design strategy that combined covalent and noncovalent interactions to prepare a protein-based light-harvesting system to mimic chloroplasts...
January 6, 2017: ACS Nano
https://www.readbyqxmd.com/read/28048517/tu-h-brc-03-evaluation-of-very-high-energy-electron-vhee-beams-in-comparison-to-vmat-and-pbs-treatment-plans
#14
E Schueler, K Eriksson, E Hynning, B Loo, P Maxim
PURPOSE: The aim of this study was to evaluate the performance of very high-energy electron (VHEE) beams in comparison to clinically delivered treatment plans generated with volumetric modulated arc therapy (VMAT) and proton pencil beam scanning (PBS) technology. METHODS: Three clinical cases were selected (prostate, lung, and pediatric CNS). The VHEE plans were calculated in the Monte Carlo EGSnrc code and pencil beam doses were calculated using the DOSxyznrc MC code for 100 and 200 MeV beams...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28043109/a-possible-pathogenic-linkage-among-headache-migraine-and-nocturnal-enuresis-in-children
#15
Pietro Ferrara, Livia Dell'Aquila, Giacomo Perrone, Giulia Spina, Francesco Miconi, Valentina Rapaccini, Ester Del Vescovo, Vincenzo Di Lazzaro, Alberto Verrotti
PURPOSE: This study aims to evaluate the prevalence of headaches and migraine in children with nocturnal enuresis (NE) and to improve knowledge on these conditions. In particular, for this purpose, a possible pathogenic relationship linking both conditions and the impact of headaches and migraine on NE persistence was evaluated. METHODS: Researchers enrolled 123 children with NE, aged between 5 and 15 years, referred to the Service of Pediatrics, Campus Bio-Medico University Hospital of Rome between January 2014 and January 2015...
December 2016: International Neurourology Journal
https://www.readbyqxmd.com/read/28043076/bio-sniffer-gas-phase-biosensor-with-secondary-alcohol-dehydrogenase-s-adh-for-determination-of-isopropanol-in-exhaled-air-as-a-potential-volatile-biomarker
#16
Po-Jen Chien, Takuma Suzuki, Masato Tsujii, Ming Ye, Koji Toma, Takahiro Arakawa, Yasuhiko Iwasaki, Kohji Mitsubayashi
Exhaled breath analysis has attracted lots of researchers attention in the past decades due to its advantages such as its non-invasive property and the possibility of continuous monitoring. In addition, several volatile organic compounds in breath have been identified as biomarkers for some diseases. Particularly, studies have pointed out that concentration of isopropanol (IPA) in exhaled air might relate with certain illnesses such as liver disease, chronic obstructive pulmonary (COPD), and lung cancer. In this study, a highly sensitive and selective biochemical gas sensor (bio-sniffer) for the breath IPA concentration determination was constructed and optimized...
December 22, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28031022/analysis-of-molecular-networks-and-targets-mining-of-chinese-herbal-medicines-on-anti-aging
#17
Qi-Yu Jiang, Mei-Si Zheng, Xiao-Jing Yang, Xiao-Sheng Sun
BACKGROUND: Many kidney-tonifying Chinese herbal medicines exert effects on anti-aging by comprehensive interactions of multiple targets. However, the interactions of multi-targets targeted by effective ingredients of kidney-tonifying Chinese herbal medicines are unknown. In this study, to explore the systems pharmacology mechanisms of kidney-tonifying Chinese medicines on anti-aging, we establish the molecular networks with the interactions of multi-targets, analyze bio-functions and pathways with IPA, and calculated the mutual interaction pairs of targets (target pairs) with data mining, respectively...
December 28, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28009968/the-dielectrophoretic-disassociation-of-chloride-ions-and-the-influence-on-diamagnetic-anisotropy-in-cell-membranes
#18
Marcy C Purnell, Terence J Skrinjar
Chloride channels represent ubiquitously expressed proteins that regulate fundamental cellular processes including membrane potential, maintenance of intracellular pH, and regulation of cell volume. However, mechanisms to modulate this large family of ion channels have remained elusive to date. This large chloride channel family does not appear to operate with selectivity similar to the sodium and potassium channels. These unique channels appear to be bi-directional cotransporters of two or more different molecules or ions across a bilayer phospholipid membrane...
November 2016: Discovery Medicine
https://www.readbyqxmd.com/read/28004532/a-model-study-to-unravel-the-complexity-of-bio-oil-from-organic-wastes
#19
Annamaria Croce, Ezio Battistel, Stefano Chiaberge, Silvia Spera, Francesco De Angelis, Samantha Reale
Binary and ternary mixtures of cellulose, bovine serum albumin (BSA) and tripalmitin, as biomass reference compounds for carbohydrates, proteins and triglycerides, respectively, were treated under hydrothermal liquefaction (HTL) conditions to describe the main reaction pathways involved in the process of bio-oil production from municipal organic wastes. Several analytical techniques (elemental analysis, GC-MS, atmospheric-pressure photo-ionisation high-resolution Fourier transform ion cyclotron resonance mass spectrometry, and (13) C cross-polarisation magic-angle spinning NMR spectroscopy) were used for the molecular-level characterisation of the resulting aqueous phase, solid residue and bio-oil, in particular...
December 22, 2016: ChemSusChem
https://www.readbyqxmd.com/read/28000052/itraq-based-quantitative-proteomics-reveals-important-host-factors-involved-in-the-high-pathogenicity-of-the-h5n1-avian-influenza-virus-in-mice
#20
Jiao Hu, Zhao Gao, Xiaoquan Wang, Min Gu, Yanyan Liang, Xiaowen Liu, Shunlin Hu, Huimou Liu, Wenbo Liu, Sujuan Chen, Daxin Peng, Xiufan Liu
We previously reported a pair of H5N1 avian influenza viruses which are genetically similar but differ greatly in their virulence in mice. A/Chicken/Jiangsu/k0402/2010 (CK10) is highly lethal to mice, whereas A/Goose/Jiangsu/k0403/2010 (GS10) is avirulent. In this study, to investigate the host factors that account for their virulence discrepancy, we compared the pathology and host proteome of the CK10- or GS10-infected mouse lung. Moderate lung injury was observed from CK10-infected animals as early as the first day of infection, and the pathology steadily progressed at later time point...
December 20, 2016: Medical Microbiology and Immunology
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