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https://www.readbyqxmd.com/read/27931238/elaboration-of-a-nomogram-to-predict-nonsentinel-node-status-in-breast-cancer-patients-with-positive-sentinel-node-intraoperatively-assessed-with-one-step-nucleic-amplification-retrospective-and-validation-phase
#1
Franco Di Filippo, Simona Di Filippo, Anna Maria Ferrari, Raffaele Antonetti, Alessandro Battaglia, Francesca Becherini, Laia Bernet, Renzo Boldorini, Catherine Bouteille, Simonetta Buglioni, Paolo Burelli, Rafael Cano, Vincenzo Canzonieri, Pierluigi Chiodera, Alfredo Cirilli, Luigi Coppola, Stefano Drago, Luca Di Tommaso, Privato Fenaroli, Roberto Franchini, Andrea Gianatti, Diana Giannarelli, Carmela Giardina, Florence Godey, Massimo M Grassi, Giuseppe B Grassi, Siobhan Laws, Samuele Massarut, Giuseppe Naccarato, Maria Iole Natalicchio, Sergio Orefice, Fabrizio Palmieri, Tiziana Perin, Manuela Roncella, Massimo G Roncalli, Antonio Rulli, Angelo Sidoni, Corrado Tinterri, Maria C Truglia, Isabella Sperduti
BACKGROUND: Tumor-positive sentinel lymph node (SLN) biopsy results in a risk of non sentinel node metastases in micro- and macro-metastases ranging from 20 to 50%, respectively. Therefore, most patients underwent unnecessary axillary lymph node dissections. We have previously developed a mathematical model for predicting patient-specific risk of non sentinel node (NSN) metastases based on 2460 patients. The study reports the results of the validation phase where a total of 1945 patients were enrolled, aimed at identifying a tool that gives the possibility to the surgeon to choose intraoperatively whether to perform or not axillary lymph node dissection (ALND)...
December 8, 2016: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/27925692/a-method-to-generate-and-analyze-modified-myristoylated-proteins
#2
Huanyao Gao, Wei Sun, Zhiquan Song, Yanbao Yu, Li Wang, Xian Chen, Qisheng Zhang
Covalent lipid modification of proteins is essential to their cellular localizations and functions. Engineered lipid motif coupled with bio-orthogonal chemistry has been utilized to identify myristoylated or palmitoylated proteins in cells. However, whether modified proteins have similar properties as endogenous ones has not been well investigated mainly due to lack of methods to generate and analyze purified proteins. We have developed a method that utilizes metabolic interference and mass spectrometry to produce and analyze modified, myristoylated small GTPase ADP-ribosylation factor 1 (Arf1)...
December 7, 2016: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/27925410/unraveling-the-role-of-formic-acid-and-the-type-of-solvent-in-the-catalytic-conversion-of-lignin-a-holistic-approach
#3
Mikel Oregui Bengoechea, Iñaki Gandarias, Pedro Luis Arias, Tanja Barth
The role of formic acid together with the effect of the solvent type and their synergic interactions with a NiMo catalyst were studied for the conversion of lignin into bio-oil in an alcohol/formic acid media. Replacing formic acid with molecular hydrogen or isopropanol decreased the oil yield to a considerable degree, increased the solid yield and altered the nature of the bio-oil. The differences induced by the presence of molecular hydrogen were comparable to the ones observed in the isopropanol system, suggesting similar lignin conversion mechanisms for both systems...
December 7, 2016: ChemSusChem
https://www.readbyqxmd.com/read/27924016/bio-tds-bioscience-query-tool-discovery-system
#4
Etienne Z Gnimpieba, Menno S VanDiermen, Shayla M Gustafson, Bill Conn, Carol M Lushbough
Bioinformatics and computational biology play a critical role in bioscience and biomedical research. As researchers design their experimental projects, one major challenge is to find the most relevant bioinformatics toolkits that will lead to new knowledge discovery from their data. The Bio-TDS (Bioscience Query Tool Discovery Systems, http://biotds.org/) has been developed to assist researchers in retrieving the most applicable analytic tools by allowing them to formulate their questions as free text. The Bio-TDS is a flexible retrieval system that affords users from multiple bioscience domains (e...
October 18, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27923385/field-effectiveness-of-microbial-larvicides-on-mosquito-larvae-in-malaria-areas-of-botswana-and-zimbabwe
#5
Mulamuli Mpofu, Piet Becker, Kaka Mudambo, Christiaan de Jager
BACKGROUND: The successful control of malaria vectors requires the control of both the larval and adult stages. The adult control methods through indoor residual spraying (IRS) and use of long-lasting insecticidal nets (LLINs) continue to be widely used with some high measure of success. Larval control methods are also being used by a number of National Malaria Control Programmes (NMCPs) with limited understanding of its contribution. Larval control might be needed in some areas to move from malaria control to elimination...
December 6, 2016: Malaria Journal
https://www.readbyqxmd.com/read/27918290/nacre-mimetic-bulk-lamellar-composites-reinforced-with-high-aspect-ratio-glass-flakes
#6
Selen N Gurbuz Guner, Arcan F Dericioglu
Nacre-mimetic epoxy matrix composites reinforced with readily available micron-sized high aspect ratio C-glass flakes were fabricated by a relatively simple, single-step, scalable, time, cost and man-power effective processing strategy: hot-press assisted slip casting (HASC). HASC enables the fabrication of preferentially oriented two-dimensional inorganic reinforcement-polymer matrix bulk lamellar composites with a micro-scale structure resembling the brick-and-mortar architecture of nacre. By applying the micro-scale design guideline found in nacre and optimizing the relative volume fractions of the reinforcement and the matrix as well as by anchoring the brick-and-mortar architecture, and tailoring the interface between reinforcements and the matrix via silane coupling agents, strong, stiff and tough bio-inspired nacre-mimetic bulk composites were fabricated...
December 5, 2016: Bioinspiration & Biomimetics
https://www.readbyqxmd.com/read/27917703/principles-of-the-kenzan-method-for-robotic-cell-spheroid-based-3d-bioprinting
#7
Nicanor I Moldovan, Narutoshi Hibino, Koichi Nakayama
Bioprinting is a technology with the prospect to change the way many diseases are treated, by replacing the damaged tissues with live, de novo created bio-similar constructs. However, after more than a decade of incubation and many proofs-of-concept, the field is still in its infancy. The current stagnation is the consequence of its early success: the first bioprinters, and most of those which followed, were modified versions of the 3D printers used in additive manufacturing, redesigned for layer-by-layer dispersion of biomaterials...
December 4, 2016: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/27916115/highly-sensitive-and-specific-derivatization-strategy-to-profile-and-quantitate-eicosanoids-by-uplc-ms-ms
#8
Ting Hu, Cai Tie, Zhe Wang, Jin-Lan Zhang
Eicosanoids are signaling molecules mainly oxidized from arachidonic acid (ARA) and eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA). They have attracted increasing attention from the scientists attributing to their essential physiological functions. However, their quantification have long been challenged by the low abundance, high structure similarity, poor stability and limited ionization efficiency. In this paper, an ultra-high performance liquid chromatograph coupled with tandem mass spectrometry (UPLC-MS/MS) strategy was developed for the comprehensive profiling of more than 60 eicosanoids based on an efficient derivatization reagent 2,4-bis(diethylamino)-6-hydrazino-1,3,5-triazine (T3) and general multiple reaction monitoring (MRM) parameters...
January 15, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/27911420/-role-of-immunological-factors-in-the-development-of-myopic-choroidal-neovascularization
#9
A G Shchuko, N V Zaitseva, T N Yur'eva, E R Chernykh, I M Mikhalevich, A V Grigor'eva
AIM: To study the concentration of cytokines in the aqueous humor of the anterior chamber in patients with myopic choroidal neovascularization (mCNV) and to compare the results to their ophthalmic status. MATERIAL AND METHODS: A total of 19 patients (19 eyes) with mCNV treated with intravitreal ranibizumab were included in the study. The control group consisted of 15 patients (15 eyes) with myopia who had cataract surgery. Age, sex, and refractive error distribution were similar to that in the study group...
2016: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/27911258/clostridium-guangxiense-sp-nov-and-clostridium-neuense-sp-nov-two-phylogenetically-closely-related-hydrogen-producing-species-isolated-from-lake-sediment
#10
Xin Zhao, Danyang Li, Shuhong Xu, Zhanghao Guo, Yan Zhang, Lin Man, Binhui Jiang, Xiaomin Hu
Two novel anaerobic, mesophilic, bio-hydrogen producing bacteria, designated strains ZGM211T and G1T, were isolated from lake sediment. 16S rRNA and ATP synthase beta subunit (atpD) gene sequences phylogenetic analysis of strains ZGM211T and G1T revealed an affiliation to the genus Clostridium sensu stricto (cluster I of the clostridia), with Clostridium acetobutylicum as the closest characterized species, showing the same sequence similarity of 96.4% to the type strain (98.9% between the two isolates). Cells of the two strains were rod-shaped...
December 1, 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/27906686/investigation-of-collective-behaviour-and-electrocommunication-in-the-weakly-electric-fish-mormyrus-rume-through-a-biomimetic-robotic-dummy-fish
#11
Elisa Donati, Martin Worm, Stefano Mintchev, Marleen van der Wiel, Giovanni Benelli, Gerhard von der Emde, Cesare Stefanini
A robotic fish has been developed to create a mixed bio-hybrid system made up of weakly electric fish and a mobile dummy fish. Weakly electric fish are capable of interacting with each other via sequences of self-generated electric signals during electrocommunication. Here we present the design of an artificial dummy fish, which is subsequently tested in behavioural experiments. The robot consists of two parts: a flexible tail that can move at different frequencies and amplitudes, performing a carangiform oscillation, and a rigid head containing the motor for the tail oscillation...
December 1, 2016: Bioinspiration & Biomimetics
https://www.readbyqxmd.com/read/27906391/large-area-growth-of-vertically-aligned-luminescent-mos2-nanosheets
#12
G Deokar, N S Rajput, P Vancsó, F Ravaux, M Jouiad, D Vignaud, F Cecchet, J-F Colomer
Vertically aligned MoS2 nanosheets (NSs) with exposed edges were successfully synthesized over a large area (∼2 cm(2)). The NSs were grown using an ambient pressure chemical vapor deposition technique via rapid sulfurization of sputter deposited thick molybdenum films. Extensive characterization of the grown MoS2 NSs has been carried out using high resolution scanning and transmission electron microscopy (SEM & TEM). A special care was given to the TEM lamella preparation process by means of a focused ion beam to preserve the NS growth direction...
December 1, 2016: Nanoscale
https://www.readbyqxmd.com/read/27906156/biomimetic-sniffing-improves-the-detection-performance-of-a-3d-printed-nose-of-a-dog-and-a-commercial-trace-vapor-detector
#13
Matthew E Staymates, William A MacCrehan, Jessica L Staymates, Roderick R Kunz, Thomas Mendum, Ta-Hsuan Ong, Geoffrey Geurtsen, Greg J Gillen, Brent A Craven
Unlike current chemical trace detection technology, dogs actively sniff to acquire an odor sample. Flow visualization experiments with an anatomically-similar 3D printed dog's nose revealed the external aerodynamics during canine sniffing, where ventral-laterally expired air jets entrain odorant-laden air toward the nose, thereby extending the "aerodynamic reach" for inspiration of otherwise inaccessible odors. Chemical sampling and detection experiments quantified two modes of operation with the artificial nose-active sniffing and continuous inspiration-and demonstrated an increase in odorant detection by a factor of up to 18 for active sniffing...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27905661/artificial-cartilage-bio-matrix-formed-of-hyaluronic-acid-and-mg2-polyphosphate
#14
X Wang, M Ackermann, E Tolba, M Neufurth, F Wurm, Q Feng, S Wang, H C Schröder, W E Müller
Here we show that inorganic polyphosphate (polyP), a polyanionic metabolic regulator consisting of multiple phosphate residues linked by energy-rich phosphoanhydride bonds, is present in the synovial fluid. In a biomimetic approach, to enhance cartilage synthesis and regeneration, we prepared amorphous polyP microparticles with Mg2+ as counterions. The particles were characterised by X-ray diffraction (XRD), energy-dispersive X-ray (EDX) and Fourier transformed infrared spectroscopic (FTIR) analyses. Similar particles were obtained after addition of Mg2+ ions to a solution containing hyaluronic acid, as a major component of the synovial fluid, and soluble Na-polyP...
November 29, 2016: European Cells & Materials
https://www.readbyqxmd.com/read/27899671/repeatsdb-2-0-improved-annotation-classification-search-and-visualization-of-repeat-protein-structures
#15
Lisanna Paladin, Layla Hirsh, Damiano Piovesan, Miguel A Andrade-Navarro, Andrey V Kajava, Silvio C E Tosatto
RepeatsDB 2.0 (URL: http://repeatsdb.bio.unipd.it/) is an update of the database of annotated tandem repeat protein structures. Repeat proteins are a widespread class of non-globular proteins carrying heterogeneous functions involved in several diseases. Here we provide a new version of RepeatsDB with an improved classification schema including high quality annotations for ∼5400 protein structures. RepeatsDB 2.0 features information on start and end positions for the repeat regions and units for all entries...
November 29, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27894722/impact-of-bio-palladium-nanoparticles-bio-pd-nps-on-the-activity-and-structure-of-a-marine-microbial-community
#16
Andrea Nuzzo, Baharak Hosseinkhani, Nico Boon, Giulio Zanaroli, Fabio Fava
Biogenic palladium nanoparticles (bio-Pd NPs) represent a promising catalyst for organohalide remediation in water and sediments. However, the available information regarding their possible impact in case of release into the environment, particularly on the environmental microbiota, is limited. In this study the toxicity of bio-Pd NPs on the model marine bacterium V. fischeri was assessed. The impacts of different concentrations of bio-Pd NPs on the respiratory metabolisms (i.e. organohalide respiration, sulfate reduction and methanogenesis) and the structure of a PCB-dechlorinating microbial community enriched form a marine sediment were also investigated in microcosms mimicking the actual sampling site conditions...
January 2017: Environmental Pollution
https://www.readbyqxmd.com/read/27891120/two-major-clades-of-bradyrhizobia-dominate-symbiotic-interactions-with-pigeonpea-in-fields-of-c%C3%A3-te-d-ivoire
#17
Romain K Fossou, Dominik Ziegler, Adolphe Zézé, François Barja, Xavier Perret
In smallholder farms of Côte d'Ivoire, particularly in the northeast of the country, Cajanus cajan (pigeonpea) has become an important crop because of its multiple beneficial facets. Pigeonpea seeds provide food to make ends meet, are sold on local markets, and aerial parts serve as forage for animals. Since it fixes atmospheric nitrogen in symbiosis with soil bacteria collectively known as rhizobia, C. cajan also improves soil fertility and reduces fallow time. Yet, seed yields remain low mostly because farmers cannot afford chemical fertilizers...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27876708/a-bio-inspired-optical-system-with-a-polymer-membrane-and-integrated-structure
#18
Dan Liang, Xuan-Yin Wang
A bio-inspired optical imaging system with a polymer membrane and integrated structure is proposed. Similar to the human eye, the presented system has a biomimetic multilayered optical structure and utilizes a solid-liquid mixed tunable lens as the variable-focus unit. The focal length of the imaging system can be adjusted flexibly through the deformation of the tunable lens when it is compressed. A detailed description of the design principle, materials and fabrication process of the system is presented. The deformation property, adjustable range and surface roughness of the tunable lens are measured...
November 23, 2016: Bioinspiration & Biomimetics
https://www.readbyqxmd.com/read/27876389/dynamics-in-cyanobacterial-communities-from-a-relatively-stable-environment-in-an-urbanised-area-ambient-springs-in-central-poland
#19
Paulina Nowicka-Krawczyk, Joanna Żelazna-Wieczorek
Ambient springs are often cited as an example of an ecosystem with stable environmental conditions. A static biotope fosters the development of constant communities with a stable qualitative and relatively stable quantitative structure. Two years of studying cyanobacteria in different microhabitats of the rheocrenic and limnocrenic ambient springs located in urban areas showed that there is a high degree of cyanobacterial diversity and spatial and seasonal dynamics in communities. Spatial heterogeneity in relation to the type of spring and the type of microhabitat is reflected not only by a change in the quantitative structure (the number of species and their biomass), but also by a change in the composition of species...
November 19, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27874233/induction-of-hepatocyte-like-cells-from-human-umbilical-cord-derived-mesenchymal-stem-cells-by-defined-micrornas
#20
Xia Zhou, Lina Cui, Xinmin Zhou, Qiong Yang, Lu Wang, Guanya Guo, Yu Hou, Weile Cai, Zheyi Han, Yongquan Shi, Ying Han
Generating functional hepatocyte-like cells (HLCs) from mesenchymal stem cells (MSCs) is of great urgency for bio-artificial liver support system (BALSS). Previously, we obtained HLCs from human umbilical cord-derived MSCs by overexpressing seven microRNAs (HLC-7) and characterized their liver functions in vitro and in vivo. Here, we aimed to screen out the optimal miRNA candidates for hepatic differentiation. We sequentially removed individual miRNAs from the pool and examined the effect of transfection with remainder using RT-PCR, periodic acid-Schiff (PAS) staining and low-density lipoprotein (LDL) uptake assays and by assessing their function in liver injury models...
November 22, 2016: Journal of Cellular and Molecular Medicine
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