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Bio Similar

D Briassoulis, A Mistriotis
Biodegradation of plastics in soil is currently tested by international standard testing methods (e.g. ISO 17556-12 or ASTM D5988-12). Although these testing methods have been developed for plastics, it has been shown in project KBBPPS that they can be extended also to lubricants with small modifications. Reproducibility is a critical issue regarding biodegradation tests in the laboratory. Among the main testing variables are the soil types and nutrients available (mainly nitrogen). For this reason, the effect of the soil type on the biodegradation rates of various bio-based materials (cellulose and lubricants) was tested for five different natural soil types (loam, loamy sand, clay, clay-loam, and silt-loam organic)...
May 5, 2018: Chemosphere
Nader Makki, Satya Shreenivas, Dean Kereiakes, Scott Lilly
BACKGROUND: Reduced leaflet motion (RLM) of transcatheter aortic valves (TAV) is observed in up to 4% of cases with similar frequency in surgical valves, with an overall incidence that differs based on prosthesis type and size. This phenomenon likely represents subclinical leaflet thrombosis. Herein we sought to analyze the existing reported literature to assess whether or not RLM is associated with subsequent valve degeneration or cerebrovascular events. METHODS AND RESULTS: We searched PubMed, and EMBASE (2008-2017) to identify relevant studies...
April 5, 2018: Cardiovascular Revascularization Medicine: Including Molecular Interventions
Yashika Awasthi, Arun Ratn, Rajesh Prasad, Manoj Kumar, Sunil P Trivedi
Present study was designed to assess the hexavalent chromium (Cr6+ ) mediated oxidative stress that induces DNA damage and apoptosis in adult fish, Channa punctatus (35 ± 3.0 g; 14.5 ± 1.0 cm; Actinopterygii). Fishes were maintained in three groups for 15, 30 and 45 d of exposure periods. They were treated with 5% (Group T1) and 10% (Group T2) of 96 h-LC50 of chromium trioxide (Cr6+ ). Controls were run for the similar duration. A significant (p < 0.05) increment in the activities of antioxidant enzymes, SOD and CAT in liver tissues of the exposed fish evinces the persistence of oxidative stress...
May 5, 2018: Aquatic Toxicology
Layla Hirsh, Lisanna Paladin, Damiano Piovesan, Silvio C E Tosatto
RepeatsDB-lite ( is a web server for the prediction of repetitive structural elements and units in tandem repeat (TR) proteins. TRs are a widespread but poorly annotated class of non-globular proteins carrying heterogeneous functions. RepeatsDB-lite extends the prediction to all TR types and strongly improves the performance both in terms of computational time and accuracy over previous methods, with precision above 95% for solenoid structures. The algorithm exploits an improved TR unit library derived from the RepeatsDB database to perform an iterative structural search and assignment...
May 9, 2018: Nucleic Acids Research
Alejandro Ruiz-Picazo, Mª Teresa Martinez-Martinez, Sarin Colon-Useche, Ramon Iriarte, Barbara Sanchez-Dengra, Marta Gonzalez-Alvarez, Alfredo Garcia-Arieta, Isabel Gonzalez Alvarez, Marival Bermejo
The main objective of this investigation was to develop an exploratory two-step level A IVIVC for three Telmisartan oral immediate release formulations, the reference product Micardis and two generic formulations (X1 and X2). Correlation was validated with a third test formulation Y1. Experimental solubility and permeability data was obtained to confirm that Telmisartan is a class II compound under the Biopharmaceutic Classification System. BE studies plasma profiles were combined using a previously published reference scaling procedure...
May 10, 2018: Molecular Pharmaceutics
David Gur, Itai Glinert, Moshe Aftalion, Yaron Vagima, Yinon Levy, Shahar Rotem, Ayelet Zauberman, Avital Tidhar, Arnon Tal, Sharon Maoz, Raphael Ber, Avi Pass, Emanuelle Mamroud
Pneumonic plague is an infectious disease characterized by rapid and fulminant development of acute pneumonia and septicemia that results in death within days of exposure. The causative agent of pneumonic plague, Yersinia pestis (Y. pestis) , is a Tier-1 bio-threat agent. Parenteral antibiotic treatment is effective when given within a narrow therapeutic window after symptom onset. However, the non-specific "flu-like" symptoms often lead to delayed diagnosis and therapy. In this study, we evaluated inhalational gentamicin therapy in an infected mouse model as a means to improve antibiotic treatment efficacy...
2018: Frontiers in Microbiology
Antoine Venault, Min-Wen Lai, Jheng-Fong Jhong, Chih-Chen Yeh, Lu-Chen Yeh, Yung Chang
The field of bio-inert materials is relatively mature as unique molecular designs for antifouling have been regularly presented over the past 30 years. However, the effect of steam sterilization, a common procedure in hospitals for sterilizing biomedical devices in clinical uses, on the stability of antifouling and hemocompatible biomaterials remains unexplored. The only available set of data indicates that poly(sulfobetaine methacrylate) (SBMA) is unstable and loses its antifouling properties when exposed to hot humid air, depriving it of its attractiveness...
May 8, 2018: ACS Applied Materials & Interfaces
Sudarat Hadpech, Wannarat Jinathep, Somphot Saoin, Weeraya Thongkum, Koollawat Chupradit, Umpa Yasamut, Sutpirat Moonmuang, Chatchai Tayapiwatana
The requirement for reliable bicistronic or multicistronic vectors in gene delivery systems is at the forefront of bio/biomedical technology. A method that provides an efficient co-expression of multiple heterologous proteins would be valuable for many applications, especially in medical science for treating various types of disease. In this study, we designed and constructed a bicistronic expression vector using a self-cleaving 2A peptide derived from a virus of the insect Thosea asigna (T2A). This exhibited the most efficient cleavage of the 2A sequence...
May 4, 2018: Protein Expression and Purification
Estelle Lefrançois, Laure Apothéloz-Perret-Gentil, Philippe Blancher, Samuel Botreau, Cécile Chardon, Laura Crepin, Tristan Cordier, Arielle Cordonier, Isabelle Domaizon, Benoit J D Ferrari, Julie Guéguen, Jean-Christophe Hustache, Louis Jacas, Stephan Jacquet, Sonia Lacroix, Anne-Laurence Mazenq, Alina Pawlowska, Pascal Perney, Jan Pawlowski, Frédéric Rimet, Jean-François Rubin, Dominique Trevisan, Régis Vivien, Agnès Bouchez
The effectiveness of environmental protection measures is based on the early identification and diagnosis of anthropogenic pressures. Similarly, restoration actions require precise monitoring of changes in the ecological quality of ecosystems, in order to highlight their effectiveness. Monitoring the ecological quality relies on bioindicators, which are organisms revealing the pressures exerted on the environment through the composition of their communities. Their implementation, based on the morphological identification of species, is expensive because it requires time and experts in taxonomy...
May 7, 2018: Environmental Science and Pollution Research International
Sabina Ion, Cristina Opris, Bogdan Cojocaru, Madalina Tudorache, Irina Zgura, Aurelian C Galca, Adina M Bodescu, Madalin Enache, Gabriel-Mihai Maria, Vasile I Parvulescu
A novel and efficient one-pot system for green production of artificial lignin bio-composites has been developed. Monolignols such as sinapyl (SA) and coniferyl (CA) alcohols were linked together with caffeic acid (CafAc) affording a polymeric network similar with natural lignin. The interaction of the dissolved SA/CA with CafAc already bound on a solid support (SC2 /SC6 -CafAc) allowed the attachment of the polymeric product direct on the support surface (SC2 /SC6 -CafAc-L1 and SC2 /SC6 -CafAc-L2 , from CA and SA, respectively)...
2018: Frontiers in Chemistry
Waleed M S Al Qahtani, Mohamed I El-Anwar
A novel partnership between surgeons and machines, made possible by advances in computing and engineering technology, could overcome many of the limitations of traditional surgery. By extending surgeons' ability to plan and carry out surgical interventions more accurately and with fewer traumas, computer-integrated surgery (CIS) systems could help to improve clinical outcomes and the efficiency of healthcare delivery. CIS systems could have a similar impact on surgery to that long since realised in computer-integrated manufacturing...
April 15, 2018: Open Access Macedonian Journal of Medical Sciences
Touraj Rahimi, Ali Niazi, Tahereh Deihimi, Seyed Mohsen Taghavi, Shahab Ayatollahi, Esmaeil Ebrahimie
One of the main challenges in elimination of oil contamination from polluted environments is improvement of biodegradation by highly efficient microorganisms. Bacillus subtilis MJ01 has been evaluated as a new resource for producing biosurfactant compounds. This bacterium, which produces surfactin, is able to enhance bio-accessibility to oil hydrocarbons in contaminated soils. The genome of B. subtilis MJ01 was sequenced and assembled by PacBio RS sequencing technology. One big contig with a length of 4,108,293 bp without any gap was assembled...
May 5, 2018: Functional & Integrative Genomics
Sang Hyun Jo, Young-Kyun Kim, Yong-Hoon Choi
The purpose of this study was to measure the level of new bone formation induced by various bone graft materials to provide clinicians with more choices. The samples were divided into three groups: group 1 ( n = 9: allograft + xenograft, DBX&reg; , San Francisco, CA, USA + Bio-Oss&reg; , Princeton, NJ, USA), group 2 ( n = 10: xenograft, Bio-Oss&reg; ), and group 3 ( n = 8: autogenous tooth bone graft, AutoBT&reg; , Korea Tooth Bank, Seoul, Korea). The average duration of evaluation was 9.56, 2...
May 2, 2018: Materials
R Riccò, S Nizzero, E Penna, A Meneghello, E Cretaio, F Enrichi
In modern biosensing and imaging, fluorescence-based methods constitute the most diffused approach to achieve optimal detection of analytes, both in solution and on the single-particle level. Despite the huge progresses made in recent decades in the development of plasmonic biosensors and label-free sensing techniques, fluorescent molecules remain the most commonly used contrast agents to date for commercial imaging and detection methods. However, they exhibit low stability, can be difficult to functionalise, and often result in a low signal-to-noise ratio...
2018: Journal of Nanoparticle Research: An Interdisciplinary Forum for Nanoscale Science and Technology
N Haghighian, D Convertino, V Miseikis, F Bisio, A Morgante, C Coletti, M Canepa, O Cavalleri
The surface structure of Few-Layer Graphene (FLG) epitaxially grown on the C-face of SiC has been investigated by TM-AFM in ambient air and upon interaction with dilute aqueous solutions of bio-organic molecules (l-methionine and dimethyl sulfoxide, DMSO). Before interaction with molecular solutions, we observe nicely ordered, three-fold oriented rippled domains, with a 4.7 ± 0.2 nm periodicity (small periodicity, SP) and a peak-to-valley distance in the range 0.1-0.2 nm. Upon mild interaction with the molecular solution, the ripple periodicity "relaxes" to 6...
May 2, 2018: Physical Chemistry Chemical Physics: PCCP
H B Santhosh, C S K Raju
This study explores the magneto hydrodynamic Carreau fluid in the interruption of titanium alloy nanoparticles with heat generation and porosity. The simulation is performed by combination of titanium alloy nanoparticles into base water. Titanium is strong and light in weight and sit is used in military and aerospace, in bio science it is used as anti-microbial, anti-biotic, and anti-fungal agents. The arising set of partial differential equations (P.D.E) are converted into set of ordinary differential equation (O...
April 27, 2018: Journal of Integrative Neuroscience
Hongyun Nie, Maiqian Nie, Lei Wang, Zhenjun Diwu, Ting Xiao, Qi Qiao, Yan Wang, Xin Jiang
The aim of this work was to investigate the effects of secreted extracellular phenazine compounds (PHCs) on the degradation efficiency of alkanes by P. aeruginosa NY3. Under aerobic conditions, the PHCs secreted by P. aeruginosa NY3 initiate the oxidation of alkanes outside cells, in coupling with some reducing agents, such as β-Nicotinamide adenine dinucleotide, reduced disodium salt (NADH) or reduced glutathione (GSH). This reaction might be via free radical reactions similar to Fenton Oxidation Reaction (FOR)...
March 2, 2018: Water Research
Juhani Multanen, Arja Häkkinen, Pauli Heikkinen, Hannu Kautiainen, Sirpa Mustalampi, Jari Ylinen
Low-energy pulsed electromagnetic field (PEMF) therapy has been suggested as a promising therapy to increase microcirculation, which is of great concern in patients with fibromyalgia. This study evaluated the effectiveness of PEMF therapy on the treatment of fibromyalgia. A group of 108 women with fibromyalgia were allocated to a 12-week treatment period with an active Bio-Electro-Magnetic-Energy-Regulation (BEMER) device and a similar treatment period with an inactive device. Each patient received active and sham treatments in a random order...
April 30, 2018: Bioelectromagnetics
Andrea Giorgi, Maurizio Vicini, Luca Pollastri, Erica Lombardi, Emilio Magni, Andrea Andreazzoli, Marco Orsini, Marco Bonifazi, Henry Lukaski, Hannes Gatterer
Bioelectrical impedance vector-analysis (BIVA) describes cell-mass, cell function and hydration status of an individual or a group. The goal of the present investigation was to provide bioelectrical impedance data for 525 male road cyclists (155 professionals, 79 elite, 59 elite-youth, and 232 amateurs) at the time of their optimal performance level. Data were plotted on the resistance-reactance (R-Xc) graph to characterize cyclists group vectors using BIVA. Compared to the general male population, the mean vector position of the road cyclists indicates a higher body cell mass (BCM) and phase angle (p<0...
April 30, 2018: Journal of Sports Sciences
Chia-Fei Liu, Tzu-Hsin Lee, Jeng-Fen Liu, Wen-Tao Hou, Shu-Jun Li, Yu-Lin Hao, Haobo Pan, Her-Hsiung Huang
Ti-24Nb-4Zr-8Sn (Ti2448), a new β-type Ti alloy, consists of nontoxic elements and exhibits a low uniaxial tensile elastic modulus of approximately 45 GPa for biomedical implant applications. Nevertheless, the bio-corrosion resistance and biocompatibility of Ti2448 alloys must be improved for long-term clinical use. In this study, a rapid electrochemical anodization treatment was used on Ti2448 alloys to enhance the bio-corrosion resistance and bone cell responses by altering the surface characteristics...
April 26, 2018: Scientific Reports
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