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https://www.readbyqxmd.com/read/28545245/multimodal-bio-inspired-tactile-sensing-module-for-surface-characterization
#1
Thiago Eustaquio Alves de Oliveira, Ana-Maria Cretu, Emil M Petriu
Robots are expected to recognize the properties of objects in order to handle them safely and efficiently in a variety of applications, such as health and elder care, manufacturing, or high-risk environments. This paper explores the issue of surface characterization by monitoring the signals acquired by a novel bio-inspired tactile probe in contact with ridged surfaces. The tactile module comprises a nine Degree of Freedom Microelectromechanical Magnetic, Angular Rate, and Gravity system (9-DOF MEMS MARG) and a deep MEMS pressure sensor embedded in a compliant structure that mimics the function and the organization of mechanoreceptors in human skin as well as the hardness of the human skin...
May 23, 2017: Sensors
https://www.readbyqxmd.com/read/28544383/self-assembled-biomimetic-chloroplast-coupled-photoenzymatic-reaction-for-sustainable-synthesis-of-fuel
#2
Xuehai Yan, Kai Liu, Chengqian Yuan, Qianli Zou, Zengchun Xie
Prototypes of biosystems provide good blueprints for the design and creation of biomimetic systems. However, mimicking both the sophisticated natural structures and their complex biological functions still remains a great challenge. Herein, biomimetic chloroplasts have been fabricated by one-step bio-inspired amino acid mineralization and simultaneous integration of catalytically active units. Hierarchically structured crystals are obtained by metal ion-directed self-assembly of cystine (the oxidized dimer form of the amino acid cysteine), with porous structure and stacking nanorods, which show similar architectural principles to chloroplasts...
May 22, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28542224/is-spaceflight-induced-immune-dysfunction-linked-to-systemic-changes-in-metabolism
#3
Michael J Pecaut, Xiao Wen Mao, Denise L Bellinger, Karen R Jonscher, Louis S Stodieck, Virginia L Ferguson, Ted A Bateman, Robert P Mohney, Daila S Gridley
The Space Shuttle Atlantis launched on its final mission (STS-135) on July 8, 2011. After just under 13 days, the shuttle landed safely at Kennedy Space Center (KSC) for the last time. Female C57BL/6J mice flew as part of the Commercial Biomedical Testing Module-3 (CBTM-3) payload. Ground controls were maintained at the KSC facility. Subsets of these mice were made available to investigators as part of NASA's Bio-specimen Sharing Program (BSP). Our group characterized cell phenotype distributions and phagocytic function in the spleen, catecholamine and corticosterone levels in the adrenal glands, and transcriptomics/metabolomics in the liver...
2017: PloS One
https://www.readbyqxmd.com/read/28541666/unveiling-the-molecular-structure-of-pulmonary-surfactant-corona-on-nanoparticles
#4
Qinglin Hu, Xuan Bai, Guoqing Hu, Yi Y Zuo
The growing risk of human exposure to airborne nanoparticles (NPs) causes a general concern on the biosafety of nanotechnology. Inhaled NPs can deposit in the deep lung at which interacting with the pulmonary surfactant (PS). Despite the increasing study of nano-bio interactions, detailed molecular mechanisms by which inhaled NPs interact with the natural PS system remain unclear. Using coarse-grained molecular dynamics simulation, we studied the interaction between NPs and the PS system in the alveolar fluid...
May 25, 2017: ACS Nano
https://www.readbyqxmd.com/read/28540727/noiseless-performance-of-prussian-blue-based-bio-sensors-through-power-generation
#5
Maria A Komkova, Elena E Karyakina, Arkady A Karyakin
In contrast to 'self-powered' (bio)sensors aiming to generate maximum energy output, we propose the systems with the lowest potential difference between the working and the counter electrodes, which in galvanic mode would provide achievement of the best analytical performance characteristics. Prussian Blue based (bio)sensors known to operate at 0.00 V versus Ag|AgCl reference, in short-circuit regime generate the current proportional to analyte concentration. Sensitivity and dynamic range of Prussian Blue based (bio)sensors in power generation mode are, respectively, even slightly higher and wider compared to the same (bio)sensors operated in the conventional three-electrode regime powered by a potentiostat...
May 25, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28535422/detailed-characterization-of-bio-oil-from-pyrolysis-of-non-edible-seed-cakes-by-fourier-transform-infrared-spectroscopy-ftir-and-gas-chromatography-mass-spectrometry-gc-ms-techniques
#6
Vatsala Sugumaran, Shanti Prakash, Emmandi Ramu, Ajay Kumar Arora, Veena Bansal, Vivekanand Kagdiyal, Deepak Saxena
Bio-oil obtained from pyrolysis is highly complicated mixture with valued chemicals. In order to reduce the complexity for unambiguous characterization of components present in bio-oil, solvent extractions using different solvents with increasing polarity have been adopted. The fractions have been analyzed by Fourier transform infrared (FTIR) spectroscopy for identifying the functional groups and Gas chromatography-mass spectrometry (GC-MS), for detailed characterization of components present in various fractions, thereby providing in-depth information at molecular level of various components in bio-oil...
May 12, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28533175/dendrimer-encapsulated-and-conjugated-delivery-of-berberine-a-novel-approach-mitigating-toxicity-and-improving-in-vivo-pharmacokinetics
#7
Lokesh Gupta, Ashok Kumar Sharma, Avinash Gothwal, Mohammed Shahid Khan, Mahaveer Prasad Khinchi, Arem Qayum, Shashank Kumar Singh, Umesh Gupta
Berberine (BBR) is a nitrogenous cyclic natural alkaloid with potential anticancer activity. However it has been less explored due to its poor pharmacokinetic profile. Dendrimers (e.g. PAMAM) have promising potential to deliver anticancer drugs/bio-actives because of their well-defined architecture, monodispersity and tailor-made surface functionality. In the present study it was attempted to deliver berberine through G4 PAMAM dendrimers by conjugation (BPC) as well as encapsulation (BPE) approach. The developed encapsulated and conjugated berberine formulations were found to have size in the approximate range of 100-200nm while zeta potential was almost same as PAMAM G4 dendrimer...
May 19, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28532660/bio-equivalent-doses-of-recombinent-hcg-and-recombinent-lh-during-ovarian-stimulation-result-in-similar-oestradiol-output-a-randomized-controlled-study
#8
Birgit Alsbjerg, Helle Olesen Elbaek, Rita Jakubcionyte Laursen, Betina Boel Povlsen, Thor Haahr, Claus Yding Andersen, Peter Humaidan
In nature, HCG is secreted by the implanting embryo from peri-implantation and onwards. In contrast, LH is mandatory for steroidogenesis and follicular development during the follicular phase, working in synergy with FSH. Moreover, LH is mandatory for the function of the corpus luteum. Although LH and HCG bind to the same receptor, significant molecular, structural and functional differences exist, inducing differences in bioactivity. This randomized controlled study compared the effect of recombinent FSH stimulation combined with daily either micro-dose recombinent HCG or recombinent LH supplementation in a 1:1 bioactivity ratio from day 1 of stimulation in a long gonadotrophin releasing hormone agonist down regulation protocol...
May 11, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28531876/photofunctionalization-of-dental-zirconia-oxide-surface-modification-to-improve-bio-integration-preserving-crystal-stability
#9
Marco Roy, Alfonso Pompella, Jerzy Kubacki, Adam Piosik, Bronisław Psiuk, Joanna Klimontko, Jacek Szade, Robert A Roy, Wieslaw Hedzelek
The use of zirconium oxide in dental implantology is rapidly increasing as it is regarded as being more aesthetical and biologically friendly than titanium oxide. The interaction of titanium oxide with cells and proteins has proven to be significantly affected by the inevitable atmospheric hydrocarbon contamination, defined as biological ageing. The latter has proven to be effectively reversed by UVC irradiation. Crystal structures of both Zr and Ti oxides are very similar, thus also ZrO2 is prone to contamination by hydrocarbons...
May 12, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28531853/methane-production-in-an-anaerobic-osmotic-membrane-bioreactor-using-forward-osmosis-effect-of-reverse-salt-flux
#10
Sheng Li, Youngjin Kim, Sherub Phuntsho, Laura Chekli, Ho Kyong Shon, TorOve Leiknes, Noreddine Ghaffour
This study investigated the impact of reverse salt flux (RSF) on microbe community and bio-methane production in a simulated fertilizer driven FO-AnMBR system using KCl, KNO3 and KH2PO4 as draw solutes. Results showed that KH2PO4 exhibited the lowest RSF in terms of molar concentration 19.1mM/(m(2).h), while for KCl and KNO3 it was 32.2 and 120.8mM/(m(2).h), respectively. Interestingly, bio-methane production displayed an opposite order with KH2PO4, followed by KCl and KNO3. Pyrosequencing results revealed the presence of different bacterial communities among the tested fertilizers...
May 10, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28530590/metabolic-profiling-of-apples-from-different-production-systems-before-and-after-controlled-atmosphere-ca-storage-studied-by-1-h-high-resolution-magic-angle-spinning-hr-mas-nmr
#11
Martina Vermathen, Mattia Marzorati, Gaëlle Diserens, Daniel Baumgartner, Claudia Good, Franz Gasser, Peter Vermathen
Determination of metabolic alterations in apples induced by such processes as different crop protection strategies or storage, are of interest to assess correlations with fruit quality or fruit disorders. Preliminary results proposed the metabolic discrimination of apples from organic (BIO), integrated (IP) and low-input (LI) production. To determine contributions of temporal metabolic developments and to define the type of metabolic changes during storage, (1)H high resolution-magic angle spinning (HR-MAS) NMR spectroscopy of apple pulp was performed before and after two time points of controlled atmosphere storage...
October 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28528542/performance-of-a-high-pressure-liquid-chromatography-ion-mobility-mass-spectrometry-system-for-metabolic-profiling
#12
Xing Zhang, Kimberly Kew, Richard Reisdorph, Mark Sartain, Roger Powell, Michael L Armstrong, Kevin Quinn, Charmion Cruickshank-Quinn, Scott Walmsley, Samantha S Bokatzian, Ed Darland, Matthew Rain, Kenneth Imatani, Nichole Reisdorph
A commercial liquid chromatography/drift tube ion mobility-mass spectrometer (LC/IM-MS) was evaluated for its utility in global metabolomics analysis. Performance was assessed using twelve targeted metabolite standards where the limit of detection (LOD), linear dynamic range, resolving power, and collision cross section (Ω), is reported for each standard. Data was collected in three different instrument operation modes: flow injection analysis with IM-MS (FIA/IM-MS), LC/MS and LC/IM-MS. Metabolomics analyses of human plasma and HaCaT cells were used to compare the above three operation modes...
May 22, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28512177/evaluation-of-novel-process-indicators-for-rapid-monitoring-of-hydrogen-peroxide-decontamination-processes
#13
Neil P McLeod, Melanie Clifford, J Mark Sutton
Geobacillus stearothermophilus spores on stainless steel discs are routinely used as Biological Indicators (BIs) for the validation of hydrogen peroxide bio-decontamination processes. Given ongoing concerns about the reliability and response time of BIs, we explored the potential for an enzyme-based approach decontamination process evaluation. Thermostable adenylate kinase (tAK) enzyme was coated onto a solid support and exposed to hydrogen peroxide vapour, in parallel with standard commercial 6-log BIs, during a series of vapour-phase hydrogen peroxide (VPHP) cycles in a flexible film isolator...
May 15, 2017: PDA Journal of Pharmaceutical Science and Technology
https://www.readbyqxmd.com/read/28511856/measurement-of-15-n-longitudinal-relaxation-rates-in-15-nh4-spin-systems-to-characterise-rotational-correlation-times-and-chemical-exchange
#14
D Flemming Hansen
Many chemical and biological processes rely on the movement of monovalent cations and an understanding of such processes can therefore only be achieved by characterising the dynamics of the involved ions. It has recently been shown that (15)N-ammonium can be used as a proxy for potassium to probe potassium binding in bio-molecules such as DNA quadruplexes and enzymes. Moreover, equations have been derived to describe the time-evolution of (15)N-based spin density operator elements of (15)NH4(+) spin systems...
June 2017: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/28507952/comparison-of-growth-and-the-cytokines-induced-by-pathogenic-yersinia-enterocolitica-bio-serotypes-3-o-3-and-2-o-9
#15
Haoshu Yang, Wenpeng Gu, Haiyan Qiu, Guixiang Sun, Junrong Liang, Kewei Li, Yuchun Xiao, Ran Duan, Huaiqi Jing, Xin Wang
Pathogenic Yersinia enterocolitica is widely distributed in China where the primary bio-serotypes are 3/O: 3 and 2/O: 9. Recently, the distribution of 2/O: 9 strains are being gradually replaced by 3/O: 3 strains where presently 3/O: 3 strains are the major pathogenic Y. enterocolitica in China. To identify the growth conditions and cytokines induced by Y. enterocolitica and providing some clues for this shift, we performed competitive growth in vitro and in vivo for these two bio-serotype strains; and we also compared the cytokines induced by them in infected BALB/C mice...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28506203/optimization-of-microemulsion-based-transdermal-gel-of-triamcinolone
#16
Bhagyashree Chaudhari, Swati Jagdale
BACKGROUND: Triamcinolone is a long acting corticosteroid used in the treatment of arthritis, eczema, psoriasis and similar conditions which causes inflammation. Triamcinolone has half-life of 88 minutes. Prolonged oral use is associated with gastrointestinal adverse effects as peptic ulcer, abdominal distention and ulcerative esophagitis. Microemulgel offers advantage of better stability, better loading capacity and controlled release especially for drug with short half life. OBJECTIVE: Objective of the present study was to optimize microemulgel based transdermal delivery of triamcinolone...
April 25, 2017: Recent Patents on Anti-infective Drug Discovery
https://www.readbyqxmd.com/read/28505890/functioning-grouped-soil-microbial-communities-according-to-ecosystem-type-based-on-comparison-of-fallows-and-meadows-in-the-same-region
#17
Dominika Chmolowska, Dana Elhottová, Vaclav Krištůfek, Maciej Kozak, Filip Kapustka, Szymon Zubek
Predicting the composition and function of microbial communities at a bio-geographical scale, across ecosystems, is challenging. We compared six abandoned fields to six meadows to see whether soil microbial community structure and activity are more similar within the ecosystem type than between the types. We implemented bacteria and fungi phylogenetic markers profiling, phospholipids analysis, fluorescence counts of total bacteria and algae and microscopy of arbuscular mycorrhizal fungi (AMF). The functional performance of microbial communities was assessed using enzymes activity measurements as well as culturing and incubation experiments...
May 11, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28505312/soda-prediction-of-protein-solubility-from-disorder-and-aggregation-propensity
#18
Lisanna Paladin, Damiano Piovesan, Silvio C E Tosatto
Solubility is an important, albeit not well understood, feature determining protein behavior. It is of paramount importance in protein engineering, where similar folded proteins may behave in very different ways in solution. Here we present SODA, a novel method to predict the changes of protein solubility based on several physico-chemical properties of the protein. SODA uses the propensity of the protein sequence to aggregate as well as intrinsic disorder, plus hydrophobicity and secondary structure preferences to estimate changes in solubility...
May 13, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28503196/synthesis-and-analysis-of-separation-networks-for-the-recovery-of-intracellular-chemicals-generated-from-microbial-based-conversions
#19
Kirti M Yenkie, Wenzhao Wu, Christos T Maravelias
BACKGROUND: Bioseparations can contribute to more than 70% in the total production cost of a bio-based chemical, and if the desired chemical is localized intracellularly, there can be additional challenges associated with its recovery. Based on the properties of the desired chemical and other components in the stream, there can be multiple feasible options for product recovery. These options are composed of several alternative technologies, performing similar tasks. The suitability of a technology for a particular chemical depends on (1) its performance parameters, such as separation efficiency; (2) cost or amount of added separating agent; (3) properties of the bioreactor effluent (e...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/28500310/bio-inspired-nacre-like-nanolignocellulose-poly-vinyl-alcohol-tio2-composite-with-superior-mechanical-and-photocatalytic-properties
#20
Yipeng Chen, Hanwei Wang, Baokang Dang, Ye Xiong, Qiufang Yao, Chao Wang, Qingfeng Sun, Chunde Jin
Nacre, the gold standard for biomimicry, provides an excellent example and guideline for assembling high-performance composites. Inspired by the layered structure and extraordinary strength and toughness of natural nacre, nacre-like nanolignocellulose/poly (vinyl alcohol)/TiO2 composites possessed the similar layered structure of natural nacre were constructed through hot-pressing process. Poly (vinyl alcohol) and TiO2 nanoparticles have been used as nanofillers to improve the mechanical performance and synchronously endow the superior photocatalytic activity of the composites...
May 12, 2017: Scientific Reports
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