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https://www.readbyqxmd.com/read/28437818/-towards-a-rehabilitation-and-participation-oriented-psychotherapy
#1
Beate Muschalla, Jürgen Bengel, Matthias Morfeld, Ulrike Worringen
Mental disorders (such as recurrent mood disorders, personality disorders, or psychotic disorders) come along with enduring impairment in daily life activities. Therefore psychotherapeutic actions in inpatient or outpatient settings require a life-span and participation-oriented treatment perspective. Participation-oriented treatment aims at social and vocational integration in general life despite enduringly recurring or resting symptoms. According to the model of health problems offered by the International Classification of Functioning, Disability and Health, ICF (WHO, 2001), disability can be defined as context-dependent activity impairment due to illness...
April 24, 2017: Die Rehabilitation
https://www.readbyqxmd.com/read/28433556/bolus-injections-of-novel-thrombogenic-site-targeted-fusion-proteins-comprising-annexin-v-and-kunitz-protease-inhibitors-attenuate-intimal-hyperplasia-after-balloon-angioplasty
#2
Yung-Hsin Yeh, Shang-Hung Chang, Shin-Yu Chen, Chih-Jen Wen, Fu-Chan Wei, Rui Tang, Sam Achilefu, Tze-Chein Wun, Wei-Jan Chen
BACKGROUND: Systemic administrations of conventional antithrombotics reduce neointima formation after angioplasty in experimental animals. However, clinical translation of these results has not been successful due to high risk for bleeding. OBJECTIVES: We sought to determine whether novel annexin-V (ANV)-Kunitz protease inhibitor fusion proteins, TAP-ANV and ANV-6L15, can specifically target to vascular injury site and limit neointima formation without inducing systemic hypo-coagulation in a rat carotid artery balloon angioplasty injury model...
April 6, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28433149/fabrication-and-evaluation-of-thermosensitive-chitosan-collagen-%C3%AE-%C3%AE-glycerophosphate-hydrogels-for-tissue-regeneration
#3
Qifeng Dang, Kai Liu, Zhenzhen Zhang, Chengsheng Liu, Xi Liu, Ying Xin, Xiaoyu Cheng, Tao Xu, Dongsu Cha, Bing Fan
Thermosensitive hydrogels whose physiological properties are similar to extracellular matrix have been extensively used for tissue regeneration. Polysaccharides and proteins, as biocompatible substrates similar to bio-macromolecules that could be recognized by human body, are two preferred polymers for fabrication of such hydrogels. A series of novel thermosensitive hydrogels (CS-ASC-HGs) containing chitosan (CS) and acid-soluble collagen (ASC) were thus prepared, in the presence of α, β-glycerophosphate, to mimic extracellular microenvironment for tissue regeneration...
July 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28428070/no-production-and-potassium-channels-activation-induced-by-crotalus-durissus-cascavella-underlie-mesenteric-artery-relaxation
#4
S S Santos, R L C Jesus, L O Simões, W P Vasconcelos, I A Medeiros, R C Veras, L L Casais-E-Silva, D F Silva
Animal toxins are natural resources for pharmacological studies. The venom of Crotalus durissus cascavella (C.d. cascavella) may be a source in the bio-prospecting of new anti-hypertensive agents. The aim of this study was to investigate vascular effects of the venom of C.d. cascavella in normotensive rats. Studies were performed using isolated mesenteric artery segments and aortic endothelial cells. The cumulative administration of the venom of C.d. cascavella (0.001-30 μg/mL) on phenylephrine (Phe; 10 μM) pre-contracted rings induced a concentration-dependent vasorelaxation in the presence of vascular endothelium (Emax = 47...
April 18, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28426218/the-excited-state-triple-proton-transfer-reaction-of-2-6-diazaindoles-and-2-6-diazatryptophan-in-aqueous-solution
#5
Kun-You Chung, Yi-Han Chen, Yi-Ting Chen, Yen-Hao Hsu, Jiun-Yi Shen, Chi-Lin Chen, Yi-An Chen, Pi-Tai Chou
3-Me-2,6-diazaindole ((2,6-aza)Ind) was strategically designed and synthesized to probe water molecule catalyzed excited-state proton transfer in aqueous solution. Upon electronic excitation (λmax ~ 300 nm), (2,6-aza)Ind undergoes N(1)-H to N(6) long-distance proton transfer in neutral H2O, resulting in normal (340 nm) and proton-transfer tautomer (480 nm) emissions with an overall quantum yield of 0.25. The rate of the water-catalyzed proton transfer shows a prominent H/D kinetic isotope effect, which is determined to be 8...
April 20, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28415799/the-pancreas-responds-to-remote-damage-and-systemic-stress-by-secretion-of-the-pancreatic-secretory-proteins-psp-regi-and-pap-regiii
#6
Theresia Reding, Cristian Palmiere, Clinsyjos Pazhepurackel, Marc Schiesser, Daniel Bimmler, Andrea Schlegel, Ursula Süss, Sabrina Steiner, Leandro Mancina, Gitta Seleznik, Rolf Graf
INTRODUCTION: In patients with infection and sepsis serum levels of Pancreatic Stone protein/regenerating protein I (PSP) are highly elevated. The origin of PSP during these conditions is presumably the pancreas, however, an intestinal origin cannot be excluded. Similarly, pancreatitis-associated protein (PAP) was identified in the pancreas. These proteins were also localized in intestinal organs. Here we aim to elucidate the bio-distribution of PSP and PAP in animal models of sepsis and in healthy humans...
March 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28415792/a-cd44-specific-peptide-rp-1-exhibits-capacities-of-assisting-diagnosis-and-predicting-prognosis-of-gastric-cancer
#7
Weiming Li, Huan Jia, Jichang Wang, Hao Guan, Yan Li, Dan Zhang, Yanan Tang, Thomas D Wang, Shaoying Lu
Early diagnosis and evaluation of prognosis are both crucial for preventing poor prognosis of patients with gastric cancer (GC), a leading cause of cancer-related deaths worldwide. Cluster of differentiation 44 (CD44), an indicator of cancer stem cells, can be specifically targeted by molecular probes and detected in tissues of GC in a large quantity. In current study we found that RP-1, a specific peptide binding to CD44 protein, exhibited the potentials of specific binding to CD44 high-expressing cancer cells both in vitro and in vivo, and the capacity of predicting prognosis of human GC in a microarray assay...
March 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28414137/novel-dabigatran-etexilate-hemisuccinate-loaded-polycap-physicochemical-characterisation-and-in-vivo-evaluation-in-beagle-dogs
#8
Jung Hyun Cho, Jin Cheul Kim, Hyung-Seo Kim, Dong Shik Kim, Kyeong Soo Kim, Yong Il Kim, Chul Soon Yong, Jong Oh Kim, Yu Seok Youn, Kyung Taek Oh, Jong Soo Woo, Han-Gon Choi
The purpose of this study was to develop a novel dabigatran etexilate hemisuccinate (DEH) salt-loaded polycap with bioequivalence to the dabigatran etexilate mesylate (DEM)-loaded commercial product. DEH prepared with dabigatran etexilate base (DE) and succinic acid was less hygroscopic but less soluble than DEM. Numerous micronized DEHs and DEH-loaded solid dispersions were prepared employing the spiral jet-milling and spray-drying techniques, respectively. Among the formulations prepared, a micronized DEH prepared with the injection air at 1...
April 13, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28411627/combination-of-electrospray-ionization-atmospheric-pressure-photoionization-and-laser-desorption-ionization-fourier-transform-ion-cyclotronic-resonance-mass-spectrometry-for-the-investigation-of-complex-mixtures-application-to-the-petroleomic-analysis-of-bio
#9
Jasmine Hertzog, Vincent Carré, Yann Le Brech, Colin Logan Mackay, Anthony Dufour, Ondřej Mašek, Frédéric Aubriet
The comprehensive description of complex mixtures such as bio-oils is required to understand and improve the different processes involved during biological, environmental or industrial operation. In this context, we have to consider how different ionization sources can improve a non-targeted approach. Thus, the Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) has been coupled to electrospray ionization (ESI), laser desorption ionization (LDI) and atmospheric pressure photoionization (APPI) to characterize an oak pyrolysis bio-oil...
May 29, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28382045/genome-wide-identification-of-the-mikc-type-mads-box-gene-family-in-gossypium-hirsutum-l-unravels-their-roles-in-flowering
#10
Zhongying Ren, Daoqian Yu, Zhaoen Yang, Changfeng Li, Ghulam Qanmber, Yi Li, Jie Li, Zhao Liu, Lili Lu, Lingling Wang, Hua Zhang, Quanjia Chen, Fuguang Li, Zuoren Yang
Cotton is one of the major world oil crops. Cottonseed oil meets the increasing demand of fried food, ruminant feed, and renewable bio-fuels. MADS intervening keratin-like and C-terminal (MIKC)-type MADS-box genes encode transcription factors that have crucial roles in various plant developmental processes. Nevertheless, this gene family has not been characterized, nor its functions investigated, in cotton. Here, we performed a comprehensive analysis of MIKC-type MADS genes in the tetraploid Gossypium hirsutum L...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28381363/flow-modulated-comprehensive-two-dimensional-gas-chromatography-combined-with-a-vacuum-ultraviolet-detector-for-the-analysis-of-complex-mixtures
#11
Mariosimone Zoccali, Kevin A Schug, Phillip Walsh, Jonathan Smuts, Luigi Mondello
The present paper is focused on the use of a vacuum ultraviolet absorption spectrometer (VUV) for gas chromatography (GC), within the context of flow modulated comprehensive two-dimensional gas chromatography (FM GC×GC). The features of the VUV detector were evaluated through the analysis of petrochemical and fatty acids samples. Besides responding in a predictable fashion via Beer's law principles, the detector provides additional spectroscopic information for qualitative analysis. Virtually all chemical species absorb and have unique gas phase absorption features in the 120-240nm wavelength range monitored...
March 28, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28378730/-characteristics-of-the-expression-of-the-transcription-factor-pstat3-in-asthma
#12
V N Mineev, T M Lalaeva
AIM: To investigate the transcription factor pSTAT3 in overweight asthmatics on a model of peripheral blood mononuclear cells at baseline and during recombinant leptin modulation. MATERIAL AND METHODS: A flow fluorometric assay was used according to the standard Bio-Plex protocol on a Bio-Plex immunoanalyzer (a flow fluorimeter) (Bio-Rad, USA) using xMAP technology at baseline and during modulation with recombinant leptin (Leptin, human, recombinant, expressed in a E...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28378729/-role-of-negative-regulators-of-socs1-socs3-and-socs5-gene-transcription-in-the-negative-cell-signaling-regulation-system-in-asthma
#13
L N Sorokina, V N Mineev, V V Lim
AIM: To conduct a comprehensive study of the components of negative cell signaling regulation in different types of asthma. SUBJECTS AND METHODS: A total of 171 people, including 80 patients with allergic asthma (AA), 60 patients with non-allergic asthma (NAA), and 31 apparently healthy individuals, were examined. SOCS5 mRNA expression was assessed by reverse-transcription polymerase chain reaction. The expression of SOCS1 and SOCS3 proteins was investigated by immunoblotting...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28378354/ecological-regime-shift-drives-declining-growth-rates-of-sea-turtles-throughout-the-west-atlantic
#14
Karen A Bjorndal, Alan B Bolten, Milani Chaloupka, Vincent S Saba, Cláudio Bellini, Maria A G Marcovaldi, Armando J B Santos, Luis Felipe Wurdig Bortolon, Anne B Meylan, Peter A Meylan, Jennifer Gray, Robert Hardy, Beth Brost, Michael Bresette, Jonathan C Gorham, Stephen Connett, Barbara Van Sciver Crouchley, Mike Dawson, Deborah Hayes, Carlos E Diez, Robert P van Dam, Sue Willis, Mabel Nava, Kristen M Hart, Michael S Cherkiss, Andrew G Crowder, Clayton Pollock, Zandy Hillis-Starr, Fernando A Muñoz Tenería, Roberto Herrera-Pavón, Vanessa Labrada-Martagón, Armando Lorences, Ana Negrete-Philippe, Margaret M Lamont, Allen M Foley, Rhonda Bailey, Raymond R Carthy, Russell Scarpino, Erin McMichael, Jane A Provancha, Annabelle Brooks, Adriana Jardim, Milagros López-Mendilaharsu, Daniel González-Paredes, Andrés Estrades, Alejandro Fallabrino, Gustavo Martínez-Souza, Gabriela M Vélez-Rubio, Ralf H Boulon, Jaime A Collazo, Robert Wershoven, Vicente Guzmán Hernández, Thomas B Stringell, Amdeep Sanghera, Peter B Richardson, Annette C Broderick, Quinton Phillips, Marta Calosso, John A B Claydon, Tasha L Metz, Amanda L Gordon, Andre M Landry, Donna J Shaver, Janice Blumenthal, Lucy Collyer, Brendan J Godley, Andrew McGowan, Matthew J Witt, Cathi L Campbell, Cynthia J Lagueux, Thomas L Bethel, Lory Kenyon
Somatic growth is an integrated, individual-based response to environmental conditions, especially in ectotherms. Growth dynamics of large, mobile animals are particularly useful as bio-indicators of environmental change at regional scales. We assembled growth rate data from throughout the West Atlantic for green turtles, Chelonia mydas, which are long-lived, highly migratory, primarily herbivorous mega-consumers that may migrate over hundreds to thousands of kilometers. Our dataset, the largest ever compiled for sea turtles, has 9690 growth increments from 30 sites from Bermuda to Uruguay from 1973 to 2015...
April 4, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28375678/intracellular-distribution-and-nuclear-activity-of-antisense-oligonucleotides-after-unassisted-uptake-in-myoblasts-and-differentiated-myotubes-in-vitro
#15
Anchel González-Barriga, Bram Nillessen, Julia Kranzen, Ingeborg D G van Kessel, Huib J E Croes, Begoña Aguilera, Peter C de Visser, Nicole A Datson, Susan A M Mulders, Judith C T van Deutekom, Bé Wieringa, Derick G Wansink
Clinical efficacy of antisense oligonucleotides (AONs) for the treatment of neuromuscular disorders depends on efficient cellular uptake and proper intracellular routing to the target. Selection of AONs with highest in vitro efficiencies is usually based on chemical or physical methods for forced cellular delivery. Since these methods largely bypass existing natural mechanisms for membrane passage and intracellular trafficking, spontaneous uptake and distribution of AONs in cells are still poorly understood...
April 4, 2017: Nucleic Acid Therapeutics
https://www.readbyqxmd.com/read/28374024/bio-inspired-co2-reduction-by-a-rhenium-tricarbonyl-bipyridine-based-catalyst-appended-to-amino-acids-and-peptidic-platforms-incorporating-proton-relays-and-hydrogen-bonding-functional-groups
#16
S A Chabolla, C W Machan, J Yin, E A Dellamary, S Sahu, N C Gianneschi, M K Gilson, F A Tezcan, C P Kubiak
Herein, we report a new approach to bio-inspired catalyst design. The molecular catalyst employed in these studies is based on the robust and selective Re(bpy)(CO)3Cl-type (bpy = 2,2'-bipyridine) homogeneous catalysts, which have been extensively studied for their ability to reduce CO2 electrochemically or photochemically in the presence of a photosensitizer. These catalysts can be highly active photocatalysts in their own right. In this work, the bipyridine ligand was modified with amino acids and synthetic peptides...
April 4, 2017: Faraday Discussions
https://www.readbyqxmd.com/read/28366544/evaluation-of-dried-blood-spot-protocols-with-the-bio-rad-gs-hiv-combo-ag-ab-eia-and-geenius%C3%A2-hiv-1-2-supplemental-assay
#17
Wei Luo, Geoff Davis, LiXia Li, M Kathleen Shriver, Joanne Mei, Linda M Styer, Monica M Parker, Amanda Smith, Gabriela Paz-Bailey, Steve Ethridge, Laura Wesolowski, S Michele Owen, Silvina Masciotra
OBJECTIVE: FDA-approved antigen/antibody combo and HIV-1/2 differentiation supplemental tests do not have claims for dried blood spot (DBS) use. We compared two DBS-modified protocols, the Bio-Rad GS HIV Combo Ag/Ab (BRC) EIA and Geenius™ HIV-1/2 (Geenius) Supplemental Assay, to plasma protocols and evaluated them in the CDC/APHL HIV diagnostic algorithm. METHODS: BRC-DBS p24 analytical sensitivity was calculated from serial dilutions of p24. DBS specimens included 11 HIV-1 seroconverters, 151 HIV-1-positive individuals, including 20 on antiretroviral therapy, 31 HIV-2-positive and one HIV-1/HIV-2-positive individuals...
March 20, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28365562/responses-of-mixed-methanotrophic-consortia-to-variable-cu-2-fe-2-ratios
#18
Karthigeyan Chidambarampadmavathy, Obulisamy Parthiba Karthikeyan, Roger Huerlimann, Gregory E Maes, Kirsten Heimann
Methane mitigation in landfill top cover soils is mediated by methanotrophs whose optimal methane (CH4) oxidation capacity is governed by environmental and complex microbial community interactions. Optimization of CH4 remediating bio-filters need to take microbial responses into account. Divalent copper (Cu(2+)) and iron (Fe(2+)) are present in landfills at variable ratios and play a vital role in methane oxidation capacity and growth of methanotrophs. This study, as a first of its kind, therefore quantified effects of variable Cu(2+) and Fe(2+) (5:5, 5:25 and 5:50 μM) ratios on mixed methanotrophic communities enriched from landfill top cover (LB) and compost soils (CB)...
March 30, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28365208/postoperative-hyperalgesia-a-clinically-applicable-narrative-review
#19
REVIEW
Avi A Weinbroum
Postoperative hyperalgesia (POH) is a condition characterized by signs and symptoms of pain despite the provision of conventional analgesia. In most cases, anesthesiologists are called upon soon after surgery, but occasionally it may occur as a late event. Persistent uncontrolled pain may transform into chronic or neuropathic pain. Correct diagnosis of POH is essential since similar phenomenon may exacerbate if misdiagnosed, while proper treatment is frequently achievable by pharmacological remedies. This review will describe the causes for POH and its bio-neuro-pharmacological basis, and clinical symptoms and signs directing the physician towards correct diagnosis of this paradoxical condition of pain, as well as modes capable of preventing POH from occurring...
March 29, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28363564/salicyl-imine-chitosan-hydrogels-supramolecular-architecturing-as-a-crosslinking-method-toward-multifunctional-hydrogels
#20
Manuela-Maria Iftime, Simona Morariu, Luminita Marin
Hydrogels based on chitosan and salicyladehyde were obtained by dynamic covalent chemistry. The unusual chitosan gelling in the presence of the monoaldehyde has been deciphered following and correlating data of NMR, FTIR, single crystal and wide angle XRD, POM and optical measurements. Of significant importance in understanding the crosslinking features was the synthesis of a model compound and the successfully growth as single crystal allowing the study of its supramolecular peculiarities. The hydrogels exhibited in SEM a porous or fibrous morphology, in good correlation with the crosslinking degree...
June 1, 2017: Carbohydrate Polymers
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