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quality of life glaucoma

Machelle T Pardue, Rachael S Allen
Diseases that affect the eye, including photoreceptor degeneration, diabetic retinopathy, and glaucoma, affect 11.8 million people in the US, resulting in vision loss and blindness. Loss of sight affects patient quality of life and puts an economic burden both on individuals and the greater healthcare system. Despite the urgent need for treatments, few effective options currently exist in the clinic. Here, we review research on promising neuroprotective strategies that promote neuronal survival with the potential to protect against vision loss and retinal cell death...
February 23, 2018: Progress in Retinal and Eye Research
Suresh Kumar, Parul Ichhpujani, Roopali Singh, Sahil Thakur, Madhu Sharma, Nimisha Nagpal
Purpose: Glaucoma significantly affects the quality of life (QoL) of a patient. Despite the huge number of glaucoma patients in India, not many, QoL studies have been carried out. The purpose of the present study was to evaluate the QoL in Indian patients with varying severity of glaucoma. Methods: This was a hospital-based, cross-sectional, analytical study of 180 patients. The QoL was assessed using orally administered QoL instruments comprising of two glaucoma-specific instruments; Glaucoma Quality of Life-15 (GQL-15) and Viswanathan 10 instrument, and 1 vision-specific instrument; National Eye Institute Visual Function Questionnaire-25 (NEIVFQ25)...
March 2018: Indian Journal of Ophthalmology
Parvaneh Katoli, Adarsh Godbole, Michael J Romanowski, Kirk Clark, Erik Meredith, Veronica Saenz-Vash, Y Karen Wang, Nancy Lewicki, Andrew A Nguyen, Jeffrey M Lynch
Myocilin (MYOC) is a secreted protein found in human aqueous humor (AH) and mutations in the MYOC gene are the most common mutation observed in glaucoma patients. Human AH analyzed under non-reducing conditions suggests that MYOC is not normally found in a monomeric form, but rather is predominantly dimeric. Although MYOC was first reported almost 20 years ago, a technical challenge still faced by researchers is an inability to isolate full-length MYOC protein for experimental purposes. Herein we describe two methods by which to isolate sufficient quantities of human full-length MYOC protein from mammalian cells...
February 20, 2018: Protein Expression and Purification
Cheryl L Khanna, David A Leske, Jonathan M Holmes
Importance: Health-related quality of life (HRQOL) is often reduced with glaucoma, but associated factors are poorly understood. Objective: To determine factors associated with reduced HRQOL in medically and surgically treated patients with glaucoma. Design, Setting, and Participants: Prospective cohort study at a tertiary referral glaucoma practice, with 160 consecutive, prospectively enrolled medically or surgically treated adult patients with glaucoma...
February 22, 2018: JAMA Ophthalmology
Long Su, Guannan Huang, Songtao Yin, Xia Hua, Xin Tang
BACKGROUND: The recent advancement in the management of chronic renal failure (CRF) has significantly increased the longevity of the patients, which increase the incidence of severe vitreoretinopathy. The vitrectomy is highly risky in this particular group of patients due to their systemic comorbidity. The timing surgical intervention is usually delayed because of the systemic conditions. This study is to evaluate the safety and effectiveness of 25-guage vitrectomy for severe vitreoretinopathy in the CRF patients...
February 8, 2018: BMC Ophthalmology
D John, R Parikh
OBJECTIVES: Studies in several countries have demonstrated the cost-effectiveness of population-based screening for glaucoma when targeted at high-risk groups such as older adults and with familial history of disease. This study conducts a cost-effective analysis of a hypothetical community screening and subsequent treatment programme in comparison to opportunistic case finding for glaucoma in rural India. STUDY DESIGN: A hypothetical screening programme for both primary open-angle glaucoma and angle-closure disease was built for a population aged between 40 and 69 years in rural areas of India...
February 1, 2018: Public Health
Ciro Ramos-Estebanez, Maryo Kohen, Jonathan Pace, Alireza Bozorgi, Sunil Manjila, Vilakshan Alambyan, Ifeyinwa Nwankwo, Michael DeGeorgia, Nicholas C Bambakidis, Faruk Orge
OBJECTIVE Approximately 10% of patients with subarachnoid hemorrhage (SAH) become permanently, legally blind. The average cost of lifetime support and unpaid taxes for each blind person amounts to approximately $900,000. This study evaluates the feasibility and potential role of bedside optical coherence tomography (OCT) in Terson's syndrome (TS) in patients with acute SAH (aSAH) and its potential role in blindness prevention. METHODS The authors conducted an open-label pilot study, in which 31 patients with an angiographic diagnosis of aSAH were first screened for TS with dilated funduscopy and then with OCT in the acute phase and at 6-week follow-up visits...
February 2, 2018: Journal of Neurosurgery
Bansri K Lakhani, Anthony J King
IMPORTANCE: Very little is known about healthcare professional related prescribing errors within the glaucoma setting. BACKGROUND: This study aims to quantify these errors and to explore where they occur along the prescribing pathway. DESIGN: Cross-sectional study of patients attending a specialty glaucoma clinic over a 5-month period. PARTICIPANTS: Data was collected on 109 patients. METHODS: We compared glaucoma drop regimes from 4 different sources: As documented in the hospital notes for the last appointment, the letter sent to the General Practitioner (GP), patient's self-reporting and bottles/prescriptions brought to the clinic appointment...
January 23, 2018: Clinical & Experimental Ophthalmology
Eliana Rulli, Luciano Quaranta, Ivano Riva, Davide Poli, Lital Hollander, Fabio Galli, Andreas Katsanos, Francesco Oddone, Valter Torri, Robert N Weinreb
The aim of this study was to examine the relationship between visual field (VF) loss, vision-related quality of life (QoL) and glaucoma-related symptoms in a large cohort of primary open angle glaucoma (POAG) patients. POAG patients with or without VF defects or "glaucoma suspect" patients were considered eligible. QoL was assessed using the validated versions of the 25-item National Eye Institute Visual Function Questionnaire (NEI-VFQ-25) and glaucoma-related symptoms were assessed using the Glaucoma Symptom Scale (GSS)...
January 12, 2018: Scientific Reports
Yue Wang, Sameh Alnwisi, Min Ke
BACKGROUND: We performed a meta-analysis to determine the impact of mild, moderate, and severe visual field loss on quality of life (QoL) in patients with glaucoma. METHODS: A comprehensive literature search was performed using the PubMed, Excerpta Medica dateBASE and China National Knowledge Infrastructure databases to identify relevant articles published before June 30, 2016. Patients' QoL was measured using the Glaucoma Quality of Life-15 Questionnaire (GQL-15)...
December 2017: Medicine (Baltimore)
Monica Michelotti, Dirk F de Korne, Jennifer S Weizer, Paul P Lee, Declan Flanagan, Simon P Kelly, Anne Odergren, Sukhpal S Sandhu, Charity Wai, Niek Klazinga, Aravind Haripriya, Joshua D Stein, Melanie Hingorani
BACKGROUND: To determine alignment of proposed international standard outcomes sets for ophthalmic conditions to metrics currently reported by eye hospitals. METHODS: Mixed methods comparative benchmark study, including eight eye hospitals in Australia, India, Singapore, Sweden, U.K., and U.S. All are major international tertiary care and training centers in ophthalmology. Main outcome measure is consistency of ophthalmic outcomes measures reported. RESULTS: International agreed standard outcomes (ICHOM) sets are available for cataract surgery (10 metrics) and macular degeneration (7 metrics)...
December 29, 2017: BMC Ophthalmology
Fisseha A Ayele, Banchamelak Zeraye, Yared Assefa, Kbrom Legesse, Telake Azale, Matthew J Burton
BACKGROUND: Glaucoma is a chronic disease characterized by irreversible optic nerve damage and visual field loss that leads to visual impairment and blindness; ultimately limiting personal independence and compromising overall quality of life of affected individuals. There is paucity of information on how glaucoma affects the quality of life of patients in low and middle-income countries where resources for both diagnosis and treatment of such conditions are limited. In this study we investigate the impact of glaucoma on quality of life in Ethiopian patients...
December 13, 2017: BMC Ophthalmology
Maria L Napier, Augusto Azuara-Blanco
PURPOSE OF REVIEW: Angle closure glaucoma is a leading cause of blindness globally and trends of how best to treat this disease are evolving. The advent of anterior segment imaging aids our understanding of pathogenesis and allows more robust and objective measurement of treatment modalities. We will also review recent literature regarding the role of laser and surgical interventions for the treatment of primary angle closure disease. RECENT FINDINGS: Recent studies evaluating the efficacy of laser peripheral iridotomy (LPI) in primary angle closure suspects (PACs) show that while it is a safe intervention and initially anterior chamber angle widens following the laser treatment, the effect is lost with time...
March 2018: Current Opinion in Ophthalmology
Silvio Simeone, Gianluca Pucciarelli, Marco Perrone, Gianpaolo Gargiulo, G Isabella Continisio, Assunta Guillari, Teresa Rea
INTRODUCTION: Glaucoma is often a misdiagnosed pathology and is one of the main causes of blindness in the world population.Glaucoma frequentlycauses limitations in theactivities of daily livingand changes the patient's quality of life. AIM: The purpose of our study is to describe the life experiences of subjects in southern Italy suffering from glaucoma. METHOD: Phenomenological study RESULTS: From the analysis of interviews six main themes emerged:(1) a profound change in lifestyle, (2) casual diagnosis,(3) independent research,(4) fear of blindness,(5) fear of being a burden to family, and (6) fear of familial pathology...
July 2017: Professioni Infermieristiche
J Moreno-Montañés, A Antón-López, S Duch-Tuesta, P Corsino Fernández-Vila, J García-Feijoó, E Millá-Griñó, F J Muñoz-Negrete, L Pablo-Júlvez, I Rodríguez-Agirretxe, J L Urcelay-Segura, F Ussa-Herrera, M P Villegas-Pérez
PURPOSES: The increase in quality and life expectancy, often leads to many patients asking the glaucoma specialist whether some sports, activities or hobbies would affect their illness. The aim of this article is to establish guidelines for patients, based on the scientific evidence of published papers. METHODS: Review of all published articles on glaucoma and sports or other activities. The papers were classified according to the level of scientific evidence based on the Oxford Centre for Evidence-Based Medicine classification...
November 17, 2017: Archivos de la Sociedad Española de Oftalmología
Ibrahim H Binibrahim, Anders K Bergström
PURPOSE: Is to control intraocular pressure (IOP) (up to 21 mmHg), to decrease medical treatment after trabeculectomy and to slow down or stop progression and deterioration in visual fields in glaucoma patients. METHODS: A retrospective study. The charts of all trabeculectomies done in the Department of Ophthalmology at the Skåne University Hospital, Sweden during 2010 were retrospectively evaluated. The study was performed during fall 2012, so the longest follow-up is almost 2 years...
September 2017: Oman Journal of Ophthalmology
Anthony J King, Gordon Fernie, Augusto Azuara-Blanco, Jennifer M Burr, Ted Garway-Heath, John M Sparrow, Luke Vale, Jemma Hudson, Graeme MacLennan, Alison McDonald, Keith Barton, John Norrie
BACKGROUND: Presentation with advanced glaucoma is the major risk factor for lifetime blindness. Effective intervention at diagnosis is expected to minimise risk of further visual loss in this group of patients. AIM: To compare clinical and cost-effectiveness of primary medical management compared with primary surgery for people presenting with advanced open-angle glaucoma (OAG). METHODS: Design: A prospective, pragmatic multicentre randomised controlled trial (RCT)...
October 26, 2017: British Journal of Ophthalmology
T Harutyunyan, A Giloyan, V Petrosyan
OBJECTIVES: Visual impairment and blindness are major public health problems causing significant suffering, disability, loss of productivity, and diminishing quality of life for millions of people. This study explored the factors associated with the overall vision-related quality of life (VRQoL) and its different domains in the adult population of Nagorno Karabakh and assessed the independent contribution of specific eye diseases to VRQoL. STUDY DESIGN: A cross-sectional study...
December 2017: Public Health
Malini Veerappan, Garrick Chak, Christine Shieh, Pratap Challa
INTRODUCTION: Maroteaux-Lamy syndrome (MLS) is a rare progressive condition characterized by inflammation and scarring of multiple organs. Ocular complications caused by anterior segment abnormalities commonly cause visual impairment in MLS. Angle-closure glaucoma is one such complication, but there are limited data on presentation, workup, and management of this condition. CASE PRESENTATION: This case report describes an atypical presentation of acute angle-closure glaucoma in a patient with MLS despite a prior prophylactic laser peripheral iridotomy-which would typically prevent an acute angle-closure attack-that was patent and intact at the time of angle closure...
2017: Permanente Journal
Ricardo Y Abe, Alberto Diniz-Filho, Vital P Costa, Zhichao Wu, Felipe A Medeiros
PURPOSE: To present a new methodology for investigating predictive factors associated with development of vision-related disability in glaucoma. DESIGN: Prospective, observational cohort study. PARTICIPANTS: Two hundred thirty-six patients with glaucoma followed up for an average of 4.3±1.5 years. METHODS: Vision-related disability was assessed by the 25-item National Eye Institute Visual Function Questionnaire (NEI VFQ-25) at baseline and at the end of follow-up...
January 2018: Ophthalmology
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