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Igf2 AND insulin

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https://www.readbyqxmd.com/read/27895308/epigenetic-inhibition-of-mir-663b-by-long-non-coding-rna-hotair-promotes-pancreatic-cancer-cell-proliferation-via-up-regulation-of-insulin-like-growth-factor-2
#1
Huihua Cai, Yong An, Xuemin Chen, Donglin Sun, Tongbing Chen, Yan Peng, Feng Zhu, Yong Jiang, Xiaozhou He
Pancreatic cancer is one of the most deadly cancers with a poor prognosis. Although microRNAs are involving in the carcinogenesis and development of pancreatic cancer, little information is known regarding the role of miR-663b in pancreatic cancer. In this study, the expression of miR-663b in pancreatic cancer cells was down-regulated by hypermethylation in its putative promoter region, and overexpression of miR-663b repressed cell proliferation, invasion and migration, and induced apoptosis in pancreatic cancer cells...
November 22, 2016: Oncotarget
https://www.readbyqxmd.com/read/27894252/transcriptome-analysis-reveals-the-genetic-basis-underlying-the-seasonal-development-of-keratinized-nuptial-spines-in-leptobrachium-boringii
#2
Wei Zhang, Yue Guo, Jun Li, Li Huang, Eric Gilbert Kazitsa, Hua Wu
BACKGROUND: The expression of sexually selected traits often varies with populations' breeding cycles in many animals. The elucidation of mechanisms underlying the expression of such traits is a research topic in evolutionary biology; however, the genetic basis of the seasonal development of their expression remains unknown. Male Leptobrachium boringii develop keratinized nuptial spines on their upper jaw during the breeding season that fall off when the breeding season ends. To illuminate the genetic basis for the expression of this trait and its seasonal development, we assessed the de novo transcriptome for L...
November 28, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27856936/reveglucosidase-alfa-bmn-701-an-igf-2-tagged-rhacid-%C3%AE-glucosidase-improves-respiratory-functional-parameters-in-a-murine-model-of-pompe-disease
#3
Jeff Peng, Jill Dalton, Mark Butt, Kristin Tracy, Derek Kennedy, Peter Haroldsen, Rhea Cahayag, Stephen Zoog, Charles A O'Neill, Laurie Tsuruda
Pompe disease is a rare neuromuscular disorder caused by an acid α-glucosidase (GAA) deficiency resulting in glycogen accumulation in muscle, leading to myopathy and respiratory weakness. Reveglucosidase alfa (BMN 701), is an insulin-like growth factor 2 (IGF2) tagged rhGAA that enhances rhGAA cellular uptake via a glycosylation independent IGF2-binding region of the cation-independent mannose-6-phosphate receptor (CI-MPR). These studies evaluated the effects of reveglucosidase alfa treatment on glycogen clearance in muscle relative to rhGAA as well as changes in respiratory function and glycogen clearance in respiratory related tissue in a Pompe mouse model (GAA(tm1Rabn))...
November 16, 2016: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/27716032/expressed-alleles-of-imprinted-igf2-dlk1-and-meg3-colocalize-in-3d-preserved-nuclei-of-porcine-fetal-cells
#4
Yvette Lahbib-Mansais, Harmonie Barasc, Maria Marti-Marimon, Florence Mompart, Eddie Iannuccelli, David Robelin, Juliette Riquet, Martine Yerle-Bouissou
BACKGROUND: To explore the relationship between spatial genome organization and gene expression in the interphase nucleus, we used a genomic imprinting model, which offers parental-specific gene expression. Using 3D FISH in porcine fetal liver cells, we compared the nuclear organization of the two parental alleles (expressed or not) of insulin-like growth factor 2 (IGF2), a paternally imprinted gene located on chromosome 2. We investigated whether its nuclear positioning favors specific locus associations...
October 1, 2016: BMC Cell Biology
https://www.readbyqxmd.com/read/27708216/smoking-associated-lung-cancer-prevention-by-blockade-of-the-beta-adrenergic-receptor-mediated-insulin-like-growth-factor-receptor-activation
#5
Hye-Young Min, Hye-Jin Boo, Ho Jin Lee, Hyun-Ji Jang, Hye Jeong Yun, Su Jung Hwang, John Kendal Smith, Hyo-Jong Lee, Ho-Young Lee
Activation of receptor tyrosine kinases (RTKs) is associated with carcinogenesis, but its contribution to smoking-associated lung carcinogenesis is poorly understood. Here we show that a tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced insulin-like growth factor 1 receptor (IGF-1R) activation via β-adrenergic receptor (β-AR) is crucial for smoking-associated lung carcinogenesis. Treatment with NNK stimulated the IGF-1R signaling pathway in a time- and dose-dependent manner, which was suppressed by pharmacological or genomic blockade of β-AR and the downstream signaling including a Gβγ subunit of β-AR and phospholipase C (PLC)...
September 29, 2016: Oncotarget
https://www.readbyqxmd.com/read/27687727/prohibitin-1-regulates-the-h19-igf2-axis-and-proliferation-in-hepatocytes
#6
Komal Ramani, Nirmala Mavila, Kwang Suk Ko, José M Mato, Shelly C Lu
Prohibitin 1 (PHB1) is a mitochondrial chaperone that regulates cell growth. Phb1 knock-out mice exhibit liver injury and hepatocellular carcinoma (HCC). Phb1 knock-out livers show induction of tumor growth-associated genes, H19 and insulin-like growth factor 2 (Igf2). These genes are controlled by the imprinting control region (ICR) containing CCCTC-binding transcription factor (CTCF)-binding sites. Because Phb1 knock-out mice exhibited induction of H19 and Igf2, we hypothesized that PHB1-mediated regulation of the H19-Igf2 axis might control cell proliferation in normal hepatocytes...
November 11, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27667266/upregulation-of-ins-igf2-read-through-expression-and-identification-of-a-novel-ins-igf2-splice-variant-in-insulinomas
#7
Lene E Johannessen, Ioannis Panagopoulos, Sven-Petter Haugvik, Ivar Prydz Gladhaug, Sverre Heim, Francesca Micci
Fusion transcripts arising from the combination of exons residing on neighboring genes on the same chromosome may give rise to chimeric or novel proteins. Such read-through transcripts have been detected in different cancers where they may be of pathogenetic interest. In this study, we describe for the first time the expression of a read-through transcript in insulinomas, a functioning neuroendocrine pancreatic neoplasm. The read-through transcript INS-IGF2, composed of exons from the two genes proinsulin precursor (INS) and insulin‑like growth factor 2 (IGF2), both mapping to chromosomal subband 11p15...
September 23, 2016: Oncology Reports
https://www.readbyqxmd.com/read/27666821/the-tobacco-specific-carcinogen-operated-calcium-channel-promotes-lung-tumorigenesis-via-igf2-exocytosis-in-lung-epithelial-cells
#8
Hye-Jin Boo, Hye-Young Min, Hyun-Ji Jang, Hye Jeong Yun, John Kendal Smith, Quanri Jin, Hyo-Jong Lee, Diane Liu, Hee-Seok Kweon, Carmen Behrens, J Jack Lee, Ignacio I Wistuba, Euni Lee, Waun Ki Hong, Ho-Young Lee
Nicotinic acetylcholine receptors (nAChRs) binding to the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces Ca(2+) signalling, a mechanism that is implicated in various human cancers. In this study, we investigated the role of NNK-mediated Ca(2+) signalling in lung cancer formation. We show significant overexpression of insulin-like growth factors (IGFs) in association with IGF-1R activation in human preneoplastic lung lesions in smokers. NNK induces voltage-dependent calcium channel (VDCC)-intervened calcium influx in airway epithelial cells, resulting in a rapid IGF2 secretion via the regulated pathway and thus IGF-1R activation...
2016: Nature Communications
https://www.readbyqxmd.com/read/27651310/chronic-stress-faciliates-lung-tumorigenesis-by-promoting-exocytosis-of-igf2-in-lung-epithelial-cells
#9
Hyun-Ji Jang, Hye-Jin Boo, Ho Jin Lee, Hye-Young Min, Ho-Young Lee
Molecular insights into how chronic stress affects lung tumorigenesis may offer new routes to chemoprevention. In this study, we show that chronic stress in mice chemically or genetically initiated for lung cancer leads to the release of norepinephrine (NE) and other catecholamines, thereby promoting lung tumorigenesis. Mechanistically, NE induced phosphorylation of L-type voltage-dependent calcium channels (VDCC) through the β-adrenergic receptor (βAR)-PKA pathway. VDCC triggered calcium mobilization, thereby inducing activation of IGF-1R via exocytosis of insulin-like growth factor 2 (IGF2)...
September 20, 2016: Cancer Research
https://www.readbyqxmd.com/read/27650505/novel-deletion-in-11p15-5-imprinting-center-region-1-in-a-patient-with-beckwith-wiedemann-syndrome-provides-insight-into-distal-enhancer-regulation-and-tumorigenesis
#10
Nadine Bachmann, Roman Crazzolara, Florian Bohne, Dieter Kotzot, Kathrin Maurer, Thorsten Enklaar, Dirk Prawitt, Carsten Bergmann
BACKGROUND: Beckwith-Wiedemann syndrome (BWS) is an early-onset overgrowth disorder with a high risk for embryonal tumors. It is mainly caused by dysregulation of imprinted genes on chromosome 11p15.5; however, the driving forces in the development of tumors are not fully understood. PROCEDURE: We report on a female patient presenting with macrosomia, macroglossia, organomegaly and extensive bilateral nephroblastomatosis. Adjuvant chemotherapy was initiated; however, the patient developed hepatoblastoma and Wilms tumor at 5 and 12 months of age, respectively...
September 21, 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/27647425/rna-transcript-expression-of-igf-i-pi3k-pathway-components-in-regenerating-skeletal-muscle-is-sensitive-to-initial-injury-intensity
#11
Ronald W Matheny, Christopher T Carrigan, Mary N Abdalla, Alyssa V Geddis, Luis A Leandry, Carlos A Aguilar, Stuart S Hobbs, Maria L Urso
OBJECTIVE: Skeletal muscle regeneration is a complex process involving the coordinated input from multiple stimuli. Of these processes, actions of the insulin-like growth factor-I (IGF-I) and phosphoinositide 3-kinase (PI3K) pathways are vital; however, whether IGF-I or PI3K expression is modified during regeneration relative to initial damage intensity is unknown. The objective of this study was to determine whether mRNA expression of IGF-I/PI3K pathway components was differentially regulated during muscle regeneration in mice in response to traumatic injury induced by freezing of two different durations...
September 14, 2016: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/27643697/changes-in-insulin-like-growth-factor-signaling-alter-phenotypes-in-fragile-x-mice
#12
T L Wise
Fragile X syndrome (FXS) is an inherited form of intellectual disability that is usually caused by expansion of a polymorphic CGG repeat in the 5' untranslated region of the X-linked FMR1 gene, which leads to hypermethylation and transcriptional silencing. Two non-neurological phenotypes of FXS are enlarged testes and connective tissue dysplasia, which could be caused by alterations in a growth factor signaling pathway. FXS patients also frequently have autistic-like symptoms, suggesting that the signaling pathways affected in FXS may overlap with those affected in autism...
September 19, 2016: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/27627078/-hypoglycemia-as-a-symptom-of-cancer-in-adults
#13
Zdeněk Fryšák, David Karásek
UNLABELLED: Decrease of blood glucose levels below 3 mmol/l is in fully developed cases accompanied by neuroglycopenic symptoms that may even lead to altered state of consciousness. The treating physician frequently faces a complicated situation. This may be due to inappropriately administered drugs including cases motivated by self-harm intentions (insulin, insulin secretagogues), or alcohol abuse. Undernourished people, or those afflicted with a serious systemic infection, end-stage liver or kidney diseases or with a failing heart, belong to a risk group...
2016: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/27621468/humanized-h19-igf2-locus-reveals-diverged-imprinting-mechanism-between-mouse-and-human-and-reflects-silver-russell-syndrome-phenotypes
#14
Stella K Hur, Andrea Freschi, Folami Ideraabdullah, Joanne L Thorvaldsen, Lacey J Luense, Angela H Weller, Shelley L Berger, Flavia Cerrato, Andrea Riccio, Marisa S Bartolomei
Genomic imprinting affects a subset of genes in mammals, such that they are expressed in a monoallelic, parent-of-origin-specific manner. These genes are regulated by imprinting control regions (ICRs), cis-regulatory elements that exhibit allele-specific differential DNA methylation. Although genomic imprinting is conserved in mammals, ICRs are genetically divergent across species. This raises the fundamental question of whether the ICR plays a species-specific role in regulating imprinting at a given locus...
September 27, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27614046/igf2-is-up-regulated-by-epigenetic-mechanisms-in-hepatocellular-carcinomas-and-is-an-actionable-oncogene-product-in-experimental-models
#15
Iris Martinez-Quetglas, Roser Pinyol, Daniel Dauch, Sara Torrecilla, Victoria Tovar, Agrin Moeini, Clara Alsinet, Anna Portela, Leonardo Rodriguez-Carunchio, Manel Solé, Amaia Lujambio, Augusto Villanueva, Swan Thung, Manel Esteller, Lars Zender, Josep M Llovet
BACKGROUND & AIMS: Effective treatments are urgently needed for hepatocellular carcinoma (HCC), which is usually diagnosed at advanced stages. Signaling via the insulin-like growth factor (IGF) pathway is aberrantly activated in HCC by IGF2 overexpression. We aimed to elucidate the mechanism of IGF2 overexpression and its oncogenic activities and evaluate the anti-tumor effects of reducing IGF2 signaling. METHODS: We obtained 228 HCC samples from patients who underwent liver resection, 168 paired non-tumor adjacent cirrhotic liver samples, and 10 non-tumor liver tissues from patients undergoing resection for hepatic hemangioma...
December 2016: Gastroenterology
https://www.readbyqxmd.com/read/27596280/maternal-low-protein-diet-leads-to-placental-angiogenic-compensation-via-dysregulated-m1-m2-macrophages-and-tnf%C3%AE-expression-in-sprague-dawley-rats
#16
Emilie Vomhof-DeKrey, Diane Darland, Othman Ghribi, Amy Bundy, James Roemmich, Kate Claycombe
A maternal low-protein (LP) diet in Sprague-Dawley rats results in low birth weight, rapid adipose tissue catch-up growth, adult obesity, and insulin resistance. The placenta functions to fulfill the fetus' nutrient demands. Adequate angiogenic factor concentrations help to ensure normal growth and vasculature development of the placenta and, in turn, optimum maternal-to-fetal nutrient delivery. Maternal malnutrition creates a proinflammatory environment that leads to inhibition of placental tissue growth. Therefore, we hypothesized that a maternal LP diet will lead to abnormal angiogenesis via dysregulation of immune cells resulting in increased secretion of proinflammatory cytokines and reduced angiogenic factor expression...
August 24, 2016: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/27593483/human-cd34-lo-cd133-lo-fetal-liver-cells-support-the-expansion-of-human-cd34-hi-cd133-hi-hematopoietic-stem-cells
#17
Kylie Su Mei Yong, Choong Tat Keng, Shu Qi Tan, Eva Loh, Kenneth Te Chang, Thiam Chye Tan, Wanjin Hong, Qingfeng Chen
We have recently discovered a unique CD34(lo)CD133(lo) cell population in the human fetal liver (FL) that gives rise to cells in the hepatic lineage. In this study, we further characterized the biological functions of FL CD34(lo)CD133(lo) cells. Our findings show that these CD34(lo)CD133(lo) cells express markers of both endodermal and mesodermal lineages and have the capability to differentiate into hepatocyte and mesenchymal lineage cells by ex vivo differentiation assays. Furthermore, we show that CD34(lo)CD133(lo) cells express growth factors that are important for human hematopoietic stem cell (HSC) expansion: stem cell factor (SCF), insulin-like growth factor 2 (IGF2), C-X-C motif chemokine 12 (CXCL12), and factors in the angiopoietin-like protein family...
September 2016: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/27589905/the-developmental-transcriptome-sequencing-of-bovine-skeletal-muscle-reveals-a-long-noncoding-rna-lncmd-promotes-muscle-differentiation-by-sponging-mir-125b
#18
Xiaomei Sun, Mingxun Li, Yujia Sun, Hanfang Cai, Xianyong Lan, Yongzhen Huang, Yueyu Bai, Xinglei Qi, Hong Chen
Pervasive transcription of the mammalian genome generates numerous long noncoding RNAs (lncRNAs), which are of crucial importance in diverse biological processes. Recent advances in high throughput sequencing technology have helped to accelerate the pace of lncRNA discovery. However, no study on the overall expression patterns of lncRNAs during muscle development has been conducted. We reported here the first analysis of lncRNA landscape in bovine embryonic, neonatal and adult skeletal muscle using Ribo-Zero RNA-Seq, a technology which can capture both poly(A)(+) and poly(A)(-) transcripts...
November 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27582487/essential-role-of-dna-methyltransferase-1-mediated-transcription-of-insulin-like-growth-factor-2-in-resistance-to-histone-deacetylase-inhibitors
#19
Hye-Young Min, Su-Chan Lee, Jong Kyu Woo, Hyun Jin Jung, Kwan Hee Park, Hae Min Jeong, Seung Yeob Hyun, Jaebeom Cho, Wooin Lee, Ji Eun Park, So Jung Kwon, Hyo-Jong Lee, Xiao Ni, Young Kee Shin, Faye M Johnson, Madeleine Duvic, Ho-Young Lee
PURPOSE: Histone deacetylase inhibitors (HDIs) are promising anticancer therapies; however, drug resistance limits their efficacy. Here, we investigated the molecular mechanisms underlying HDI resistance, focusing on the mechanism of HDI-mediated induction of insulin-like growth factor 2 (IGF2) based on our previous study. EXPERIMENTAL DESIGN: The methylation status of CCCTC binding factor (CTCF)-binding sites in the IGF2/H19 imprinting control region (ICR) were determined by methylation-specific PCR and bisulfite sequencing...
August 31, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27572235/maternal-citrulline-supplementation-enhances-placental-function-and-fetal-growth-in-a-rat-model-of-iugr-involvement-of-insulin-like-growth-factor-2-and-angiogenic-factors
#20
Nhat-Thang Tran, Valerie Amarger, Aurelie Bourdon, Emilie Misbert, Isabelle Grit, Norbert Winer, Dominique Darmaun
OBJECTIVE: To determine the effects of maternal citrulline supplementation on fetal growth and placental efficiency in a rat model of IUGR induced by maternal protein restriction. METHODS: Pregnant Sprague-Dawley rats were randomly assigned to three groups: NP (receiving a control 20% protein diet), LP (a 4% protein diet), or LP-CIT (an LP diet along with L-citrulline, 2 g/kg/d in drinking water). On the 15(th) and 21(st) day of gestation (GD15 and GD21, respectively), dams underwent a C-section, by which fetuses and placentas were extracted...
August 30, 2016: Journal of Maternal-fetal & Neonatal Medicine
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