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https://www.readbyqxmd.com/read/28922596/privileged-substructures-to-modulate-protein-protein-interactions
#1
Nicolas Bosc, Mélaine A Kuenemann, Jérome Bécot, Marek Vavrusa, Adrien H Cerdan, Olivier Sperandio
Given the difficulties to identify chemical probes that can modulate protein-protein interactions (PPIs), actors in the field start to agree on the necessity to use PPI-tailored screening chemical collections. However, which type of scaffolds may promote the binding of compounds to PPI targets remains unclear. In this big data analysis, we have identified a list of privileged chemical substructures that are most often observed within inhibitors of PPIs. Using molecular frameworks as a way to perceive chemical substructures with the combination of an experimental and a machine-learning based predicted dataset of iPPI compounds, we propose a list of privileged substructures in the form of scaffolds and chemical moieties that can be substantially chemically functionalized and do not present any toxicophore nor Pan-assay interference (PAINS) alerts...
September 18, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28922158/tailored-and-adaptive-computerized-cognitive-training-in-older-adults-at-risk-for-dementia-a-randomized-controlled-trial
#2
Alex Bahar-Fuchs, Shannon Webb, Lauren Bartsch, Linda Clare, George Rebok, Nicolas Cherbuin, Kaarin J Anstey
BACKGROUND: Computerized Cognitive Training (CCT) has been shown to improve cognitive function in older adults with mild cognitive impairment (MCI) or mood-related neuropsychiatric symptoms (MrNPS), but many questions remain unresolved. OBJECTIVE: To evaluate the extent to which CCT benefits older adults with both MCI and MrNPS, and its effects on meta-cognitive and non-cognitive outcomes, as well as establish whether adapting difficulty levels and tailoring to individuals' profile is superior to generic training...
September 11, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28919130/the-nuts-and-bolts-of-cognitive-remediation-exploring-how-different-training-components-relate-to-cognitive-and-functional-gains
#3
Matteo Cella, Til Wykes
BACKGROUND: Cognitive Remediation (CR) is an evidence based treatment targeting cognitive and functional difficulties in people with psychosis. Despite the large number of effectiveness studies, only limited evidence exists for the active ingredients of this therapy. This study begins to fill this gap by exploring the relationship between CR ingredients, including alliance with a therapist, and therapy outcomes. METHOD: This is a secondary analysis based on data from a published randomised controlled trial comparing CR+treatment-as-usual (TAU) to TAU alone...
September 14, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28918760/effects-of-a-school-readiness-intervention-on-hypothalamus-pituitary-adrenal-axis-functioning-and-school-adjustment-for-children-in-foster-care
#4
Alice M Graham, Katherine C Pears, Hyoun K Kim, Jacqueline Bruce, Philip A Fisher
Maltreated children in foster care are at high risk for dysregulated hypothalamus-pituitary-adrenal (HPA) axis functioning and educational difficulties. The present study examined the effects of a short-term school readiness intervention on HPA axis functioning in response to the start of kindergarten, a critical transition marking entry to formal schooling, and whether altered HPA axis functioning influenced children's school adjustment. Compared to a foster care comparison group, children in the intervention group showed a steeper diurnal cortisol slope on the first day of school, a pattern previously observed among nonmaltreated children...
September 18, 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/28918412/prediction-of-early-unplanned-intensive-care-unit-readmission-in-a-uk-tertiary-care-hospital-a-cross-sectional-machine-learning-approach
#5
Thomas Desautels, Ritankar Das, Jacob Calvert, Monica Trivedi, Charlotte Summers, David J Wales, Ari Ercole
OBJECTIVES: Unplanned readmissions to the intensive care unit (ICU) are highly undesirable, increasing variance in care, making resource planning difficult and potentially increasing length of stay and mortality in some settings. Identifying patients who are likely to suffer unplanned ICU readmission could reduce the frequency of this adverse event. SETTING: A single academic, tertiary care hospital in the UK. PARTICIPANTS: A set of 3326 ICU episodes collected between October 2014 and August 2016...
September 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/28918392/cnvs-affecting-cancer-predisposing-genes-cpgs-detected-as-incidental-findings-in-routine-germline-diagnostic-chromosomal-microarray-cma-testing
#6
Josie Innes, Lisa Reali, Jill Clayton-Smith, Georgina Hall, Derek Hk Lim, George J Burghel, Kim French, Unzela Khan, Daniel Walker, Fiona Lalloo, D Gareth R Evans, Dominic McMullan, Eamonn R Maher, Emma R Woodward
BACKGROUND: Identification of CNVs through chromosomal microarray (CMA) testing is the first-line investigation in individuals with learning difficulties/congenital abnormalities. Although recognised that CMA testing may identify CNVs encompassing a cancer predisposition gene (CPG), limited information is available on the frequency and nature of such results. METHODS: We investigated CNV gains and losses affecting 39 CPGs in 3366 pilot index case individuals undergoing CMA testing, and then studied an extended cohort (n=10 454) for CNV losses at 105 CPGs and CNV gains at 9 proto-oncogenes implicated in inherited cancer susceptibility...
September 16, 2017: Journal of Medical Genetics
https://www.readbyqxmd.com/read/28916948/viewer-discretion-advised-is-youtube-a-friend-or-foe-in-surgical-education
#7
H Alejandro Rodriguez, Monica T Young, Hope T Jackson, Brant K Oelschlager, Andrew S Wright
BACKGROUND: In the current era, trainees frequently use unvetted online resources for their own education, including viewing surgical videos on YouTube. While operative videos are an important resource in surgical education, YouTube content is not selected or organized by quality but instead is ranked by popularity and other factors. This creates a potential for videos that feature poor technique or critical safety violations to become the most viewed for a given procedure. METHODS: A YouTube search for "Laparoscopic cholecystectomy" was performed...
September 15, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28913703/using-technology-and-assessment-to-personalize-instruction-preventing-reading-problems
#8
Carol McDonald Connor
Children who fail to learn to read proficiently are at serious risk of referral to special education, grade retention, dropping out of high school, and entering the juvenile justice system. Accumulating research suggests that instruction regimes that rely on assessment to inform instruction are effective in improving the implementation of personalized instruction and, in turn, student learning. However, teachers find it difficult to interpret assessment results in a way that optimizes learning opportunities for all of the students in their classrooms...
September 15, 2017: Prevention Science: the Official Journal of the Society for Prevention Research
https://www.readbyqxmd.com/read/28912801/efficient-multiple-kernel-learning-algorithms-using-low-rank-representation
#9
Wenjia Niu, Kewen Xia, Baokai Zu, Jianchuan Bai
Unlike Support Vector Machine (SVM), Multiple Kernel Learning (MKL) allows datasets to be free to choose the useful kernels based on their distribution characteristics rather than a precise one. It has been shown in the literature that MKL holds superior recognition accuracy compared with SVM, however, at the expense of time consuming computations. This creates analytical and computational difficulties in solving MKL algorithms. To overcome this issue, we first develop a novel kernel approximation approach for MKL and then propose an efficient Low-Rank MKL (LR-MKL) algorithm by using the Low-Rank Representation (LRR)...
2017: Computational Intelligence and Neuroscience
https://www.readbyqxmd.com/read/28904086/cognitive-trajectories-over-4-years-among-hiv-infected-women-with-optimal-viral-suppression
#10
Leah H Rubin, Pauline M Maki, Gayle Springer, Lorie Benning, Kathryn Anastos, Deborah Gustafson, Maria C Villacres, Xiong Jiang, Adaora A Adimora, Drenna Waldrop-Valverde, David E Vance, Hector Bolivar, Christine Alden, Eileen M Martin, Victor G Valcour
OBJECTIVE: To determine whether persistent viral suppression alters cognitive trajectories among HIV-infected (HIV+) women on combination antiretroviral therapy (cART) by investigating performance longitudinally in uninfected (HIV-) and 3 groups of HIV+ women: those with consistent viral suppression after continuous cART use (VS), those without consistent virologic suppression despite continuous cART use (NVS), and those without consistent virologic suppression after intermittent cART use (Int NVS)...
September 13, 2017: Neurology
https://www.readbyqxmd.com/read/28903769/specific-barriers-to-the-conduct-of-randomised-clinical-trials-on-medical-devices
#11
REVIEW
Edmund A M Neugebauer, Ana Rath, Sunya-Lee Antoine, Michaela Eikermann, Doerthe Seidel, Carsten Koenen, Esther Jacobs, Dawid Pieper, Martine Laville, Séverine Pitel, Cecilia Martinho, Snezana Djurisic, Jacques Demotes-Mainard, Christine Kubiak, Vittorio Bertele, Janus C Jakobsen, Silvio Garattini, Christian Gluud
BACKGROUND: Medical devices play an important role in the diagnosis, prevention, treatment and care of diseases. However, compared to pharmaceuticals, there is no rigorous formal regulation for demonstration of benefits and exclusion of harms to patients. The medical device industry argues that the classical evidence hierarchy cannot be applied for medical devices, as randomised clinical trials are impossible to perform. This article aims to identify the barriers for randomised clinical trials on medical devices...
September 13, 2017: Trials
https://www.readbyqxmd.com/read/28901050/do-children-understand-fraction-addition
#12
David W Braithwaite, Jing Tian, Robert S Siegler
Many children fail to master fraction arithmetic even after years of instruction. A recent theory of fraction arithmetic (Braithwaite, Pyke, & Siegler, 2017) hypothesized that this poor learning of fraction arithmetic procedures reflects poor conceptual understanding of them. To test this hypothesis, we performed three experiments examining fourth to eighth graders' estimates of fraction sums. We found that roughly half of estimates of sums were smaller than the same child's estimate of one of the two addends in the problem...
September 12, 2017: Developmental Science
https://www.readbyqxmd.com/read/28899234/a-youth-leader-program-in-baltimore-city-recreation-centers-lessons-learned-and-applications
#13
Angela C B Trude, Elizabeth Anderson Steeves, Cara Shipley, Pamela J Surkan, Priscila de Morais Sato, Tracey Estep, Stella Clanton, Lisa Lachenmayr, Joel Gittelsohn
Peer-led interventions may be an effective means of addressing the childhood obesity epidemic; however, few studies have looked at the long-term sustainability of such programs. As part of a multilevel obesity prevention intervention, B'More Healthy Communities for Kids, 16 Baltimore college students were trained as youth-leaders (YLs) to deliver a skill-based nutrition curriculum to low-income African American children (10-14 years old). In April 2015, formative research was used to inform sustainability of the YL program in recreation centers...
September 1, 2017: Health Promotion Practice
https://www.readbyqxmd.com/read/28898959/cognitive-training-using-a-novel-memory-game-on-an-ipad-in-patients-with-amnestic-mild-cognitive-impairment-amci
#14
George Savulich, Thomas Piercy, Chris Fox, John Suckling, James B Rowe, John T O'Brien, Barbara J Sahakian
Background: Cognitive training is effective in patients with mild cognitive impairment but does not typically address the motivational deficits associated with older populations with memory difficulties. Methods: We conducted a randomized controlled trial of cognitive training using a novel memory game on an iPad in 42 patients with a diagnosis of amnestic mild cognitive impairment assigned to either the cognitive training (n=21; 8 hours of gameplay over 4 weeks) or control (n=21; clinic visits as usual) groups...
August 1, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28898388/memory-and-executive-functioning-in-12-year-old-children-with-a-history-of-institutional-rearing
#15
Johanna Bick, Charles H Zeanah, Nathan A Fox, Charles A Nelson
We examined visual recognition memory and executive functioning (spatial working memory [SWM], spatial planning, rule learning, and attention shifting) in 12-year-olds (n = 150) who participated in the Bucharest Early Intervention Project, a randomized controlled trial of foster care for institutionally reared children. Similar to prior reports at 8 years of age, institutionally reared children showed significant deficits in visual recognition memory and SWM. Deficits in attention shifting and rule learning were also apparent at this time point...
September 12, 2017: Child Development
https://www.readbyqxmd.com/read/28895809/sbirt-curriculum-integration-and-sustainability-social-work-and-nursing-faculty-perspectives
#16
M Nicole Belfiore, Marcela D Blinka, Karlynn BrintzenhofeSzoc, Joseph Shields
BACKGROUND: The Substance Abuse and Mental Health Services Administration (SAMHSA) has funded grants to universities to provide training and conduct research on the dissemination of Screening, Brief Intervention, and Referral to Treatment (SBIRT) to health care professionals. However, when it comes to integrating SBIRT content into an existing curriculum, difficulties can arise. When there is so much content already in the curriculum, adding more can be challenging. Additionally, some faculty believe that course curricula should be driven by the expertise and knowledge of faculty, not by opportunities afforded because of grant funding...
September 12, 2017: Substance Abuse
https://www.readbyqxmd.com/read/28893292/reorganization-of-finger-coordination-patterns-through-motor-exploration-in-individuals-after-stroke
#17
Rajiv Ranganathan
BACKGROUND: Impairment of hand and finger function after stroke is common and affects the ability to perform activities of daily living. Even though many of these coordination deficits such as finger individuation have been well characterized, it is critical to understand how stroke survivors learn to explore and reorganize their finger coordination patterns for optimizing rehabilitation. In this study, I examine the use of a body-machine interface to assess how participants explore their movement repertoire, and how this changes with continued practice...
September 11, 2017: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/28892208/perspectives-of-oncology-nurses-and-oncologists-regarding-barriers-to-working-with-patients-from-a-minority-background-systemic-issues-and-working-with-interpreters
#18
K J Watts, B Meiser, E Zilliacus, R Kaur, M Taouk, A Girgis, P Butow, D W Kissane, S Hale, A Perry, S K Aranda, D Goldstein
This study aimed to ascertain the systemic barriers encountered by oncology health professionals (HPs) working with patients from ethnic minorities to guide the development of a communication skills training programme. Twelve medical and five radiation oncologists and 21 oncology nurses were invited to participate in this qualitative study. Participants were interviewed individually or in a focus group about their experiences working with people from minority backgrounds. All interviews were transcribed verbatim and analysed thematically...
September 11, 2017: European Journal of Cancer Care
https://www.readbyqxmd.com/read/28891404/adapted-morris-water-maze-protocol-to-prevent-interference-from-confounding-motor-deficits-on-cognitive-functioning
#19
Mattias De Coninck, Debby Van Dam, Chris Van Ginneken, Peter Paul De Deyn
Purpose/aim of the study: Cognitive functioning in the Morris Water Maze (MWM) is assumed to be reflected by path length. In this study, the interference of motor deficits, as a confounding factor on cognitive functioning, was assessed by means of a lateralization study with hemicerebellectomized (HCX) mice. This model is characterized by motor deficits restricted to the lesion side, allowing comparison within the model itself (left vs. right), rather than the effect of the manipulation on this measure (experimental vs...
September 10, 2017: Somatosensory & Motor Research
https://www.readbyqxmd.com/read/28889995/aging-and-working-memory-performance-electrophysiological-correlates-of-high-and-low-performing-elderly
#20
Alexander F Lubitz, Michael Niedeggen, Maximilian Feser
In this study we investigated age-related changes in WM capacity and their respective ERP correlates. We explicitly addressed the differentiation between high and low performing elderly to identify electrophysiological correlates of successful aging. Therefore, ERP and behavioral data was obtained from 45 young (mean = 22.73 years) and 35 older participants (mean = 68.49 years). Both groups performed a visual-spatial n-back task with two levels of difficulty. Additionally, related neuropsychological tests were administered...
September 7, 2017: Neuropsychologia
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