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https://www.readbyqxmd.com/read/29777043/new-advances-in-amblyopia-therapy-i-binocular-therapies-and-pharmacologic-augmentation
#1
Courtney L Kraus, Susan M Culican
Amblyopia therapy options have traditionally been limited to penalisation of the non-amblyopic eye with either patching or pharmaceutical penalisation. Solid evidence, mostly from the Pediatric Eye Disease Investigator Group, has validated both number of hours a day of patching and days per week of atropine use. The use of glasses alone has also been established as a good first-line therapy for both anisometropic and strabismic amblyopia. Unfortunately, visual acuity equalisation or even improvement is not always attainable with these methods...
May 18, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29773528/a-digital-app-to-aid-detection-monitoring-and-management-of-dyslexia-in-young-children-dimmand-protocol-for-a-digital-health-and-education-solution
#2
Mariam R Sood, Annet Toornstra, Martin I Sereno, Mark Boland, Daniele Filaretti, Anuj Sood
BACKGROUND: Dyslexia, a specific learning difficulty and a disability as defined in the Equality Act 2010, is a lifelong condition that affects a child from the start of education. Dyslexia is characterized by difficulties in language processing (reading, spelling, and writing) which do not correspond with the child's general intellectual abilities. Although dyslexia cannot be cured, there is a consensus that interventions are more effective and have greater impact the earlier they are administered...
May 17, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29771816/imitating-incidents-how-simulation-can-improve-safety-investigation-and-learning-from-adverse-events
#3
Carl Macrae
One of the most fundamental principles of patient safety is to investigate and learn from the past in order to improve the future. However, healthcare organizations can find it challenging to develop the robust organizational processes and work practices that are needed to rigorously investigate and learn from safety incidents. Key challenges include difficulties developing specialist knowledge and expertise, understanding complex incidents, coordinating collaborative action, and positively changing practice...
May 15, 2018: Simulation in Healthcare: Journal of the Society for Simulation in Healthcare
https://www.readbyqxmd.com/read/29771673/self-paced-prioritized-curriculum-learning-with-coverage-penalty-in-deep-reinforcement-learning
#4
Zhipeng Ren, Daoyi Dong, Huaxiong Li, Chunlin Chen
In this paper, a new training paradigm is proposed for deep reinforcement learning using self-paced prioritized curriculum learning with coverage penalty. The proposed deep curriculum reinforcement learning (DCRL) takes the most advantage of experience replay by adaptively selecting appropriate transitions from replay memory based on the complexity of each transition. The criteria of complexity in DCRL consist of self-paced priority as well as coverage penalty. The self-paced priority reflects the relationship between the temporal-difference error and the difficulty of the current curriculum for sample efficiency...
June 2018: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/29771672/reusable-reinforcement-learning-via-shallow-trails
#5
Yang Yu, Shi-Yong Chen, Qing Da, Zhi-Hua Zhou
Reinforcement learning has shown great success in helping learning agents accomplish tasks autonomously from environment interactions. Meanwhile in many real-world applications, an agent needs to accomplish not only a fixed task but also a range of tasks. For this goal, an agent can learn a metapolicy over a set of training tasks that are drawn from an underlying distribution. By maximizing the total reward summed over all the training tasks, the metapolicy can then be reused in accomplishing test tasks from the same distribution...
June 2018: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/29771671/distributed-economic-dispatch-in-microgrids-based-on-cooperative-reinforcement-learning
#6
Weirong Liu, Peng Zhuang, Hao Liang, Jun Peng, Zhiwu Huang
Microgrids incorporated with distributed generation (DG) units and energy storage (ES) devices are expected to play more and more important roles in the future power systems. Yet, achieving efficient distributed economic dispatch in microgrids is a challenging issue due to the randomness and nonlinear characteristics of DG units and loads. This paper proposes a cooperative reinforcement learning algorithm for distributed economic dispatch in microgrids. Utilizing the learning algorithm can avoid the difficulty of stochastic modeling and high computational complexity...
June 2018: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/29768543/preventing-diseases-in-round-the-world-travelers-a-contemporary-challenge-for-travel-medicine-advice
#7
Karis Maria de Pinho Rodrigues, Beatriz Meurer Moreira
Providing advice for travelers embarking on long-term trips poses a challenge in travel medicine. A long duration of risk exposure is associated with underuse of protective measures and poor adherence to chemoprophylaxis, increasing the chances of acquiring infections. Recently, in our clinic, we observed an increase in the number of travelers undertaking round-the-world trips. These individuals are typically aged around 32 years and quit their jobs to embark on one-to-two-year journeys. Their destinations include countries in two or more continents, invariably Southeast Asia and Indonesia, and mostly involve land travel and visiting rural areas...
March 2018: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29767229/usability-of-world-health-organization-disability-assessment-schedule-in-chronic-traumatic-brain-injury
#8
Sinikka Tarvonen-Schröder, Olli Tenovuo, Anne Kaljonen, Katri Laimi
OBJECTIVES: To investigate functioning measured with the 12-item World Health Organization Disability Assessment Schedule (WHODAS 2.0) in patients with mild, moderate and severe traumatic brain injury, and to compare patients' experiences with assessments made by their significant others and by consultant neurologists. METHODS: A total of 112 consecutive patients with traumatic brain injury (29 mild, 43 moderate, 40 severe) and their significant others completed a 12-item WHODAS 2...
May 16, 2018: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/29761583/handwriting-assessment-to-distinguish-comorbid-learning-difficulties-from-attention-deficit-hyperactivity-disorder-in-chinese-adolescents-a-case-control-study
#9
Cecilia W P Li-Tsang, Tim M H Li, Mandy S W Lau, Choco H Y Ho, Howard W H Leung
OBJECTIVES: Attention deficit hyperactivity disorder (ADHD) and learning difficulties (LDs) are proposed as 2 overlapping disorders. The objective of this study was to investigate the handwriting performance in ADHD and comorbid ADHD-LD adolescents. METHODS: The study examined the Chinese and English handwriting performance and sensorimotor skills of 32 ADHD, 12 ADHD-LD, and their matched controls. RESULTS: Participants with ADHD had comparable writing time and speed, but the readability was lower than their controls...
May 15, 2018: International Journal of Methods in Psychiatric Research
https://www.readbyqxmd.com/read/29757881/health-and-educational-implications-of-prematurity-in-the-united-states-national-survey-of-children-s-health-2011-2012-data
#10
Michelle M Kelly
BACKGROUND AND PURPOSE: Preterm birth is a significant public health issue, with children born prematurely experiencing educational and health difficulties throughout childhood. The aim of the descriptive secondary data analysis was to compare health implications and educational experiences in children born prematurely compared with children born at term. METHODS: The 2011/2012 National Survey of Children's Health data set was explored using separate chi-square tests of homogeneity to investigate differences in the occurrence of chronic health conditions and educationally relevant outcomes: individualized family services plan/individualized education plan (IFSP/IEP), and grade repetition between children born prematurely compared with those born at term...
March 2018: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/29757338/automated-segmentation-of-the-choroid-in-edi-oct-images-with-retinal-pathology-using-convolution-neural-networks
#11
Min Chen, Jiancong Wang, Ipek Oguz, Brian L VanderBeek, James C Gee
The choroid plays a critical role in maintaining the portions of the eye responsible for vision. Specific alterations in the choroid have been associated with several disease states, including age-related macular degeneration (AMD), central serous choroiretinopathy, retinitis pigmentosa and diabetes. In addition, choroid thickness measures have been shown as a predictive biomarker for treatment response and visual function. Where several approaches currently exist for segmenting the choroid in optical coherence tomography (OCT) images of healthy retina, very few are capable of addressing images with retinal pathology...
September 2017: Fetal, infant and ophthalmic medical image analysis: International Workshop, FIFI 2017, and 4th International Workshop, OMIA 2017, held in conjunction with MICCAI 2017, Québec City, QC, Canada, September 14, Proceedings
https://www.readbyqxmd.com/read/29756762/molecular-properties-that-define-the-activities-of-antibiotics-in-escherichia-coli-and-pseudomonas-aeruginosa
#12
Sarah J Cooper, Ganesh Krishnamoorthy, David Wolloscheck, John K Walker, Valentin V Rybenkov, Jerry M Parks, Helen I Zgurskaya
The permeability barrier of Gram-negative cell envelopes is the major obstacle in the discovery and development of new antibiotics. In Gram-negative bacteria, these difficulties are exacerbated by the synergistic interaction between two biochemically distinct phenomena, the low permeability of the outer membrane (OM) and active multidrug efflux. In this study, we used Pseudomonas aeruginosa and Escherichia coli strains with controllable permeability barriers-achieved through hyperporination of the OMs and varied efflux capacities-to evaluate the contributions of each of the barriers to protection from antibacterials...
May 14, 2018: ACS Infectious Diseases
https://www.readbyqxmd.com/read/29753921/de-novo-loss-of-function-variants-of-ash1l-are-associated-with-an-emergent-neurodevelopmental-disorder
#13
Wei Shen, Patti Krautscheid, Audrey M Rutz, Pinar Bayrak-Toydemir, Sarah L Dugan
De novo variants of ASH1L, which encodes a histone methyltransferase, have been reported in a few patients with intellectual disability and autistic features. Here, we identified a novel de novo frame-shift variant, c.2422_2423delAAinsT which predicts p.(Lys808TyrfsTer40), in ASH1L in a patient with multiple congenital anomalies (MCA), fine motor developmental delay, learning difficulties, attention deficit hyperactivity disorder, sleep apnea, and scoliosis. This frame-shift variant is expected to result in loss-of-function...
May 10, 2018: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/29752660/classification-errors-and-response-times-over-multiple-distributed-sessions-as-a-function-of-category-structure
#14
Derek E Zeigler, Ronaldo Vigo
Learning difficulty orderings for categorical stimuli have long provided an empirical foundation for concept learning and categorization research. The conventional approach seeks to determine learning difficulty orderings in terms of mean classification accuracy. However, it is relatively rare that the stability of such orderings is tested over a period of extended learning. Further, research rarely explores dependent variables beyond classification accuracy that may also indicate relative learning difficulty, such as classification response times (RTs)...
May 11, 2018: Memory & Cognition
https://www.readbyqxmd.com/read/29750689/a-prospective-observational-study-of-technical-difficulty-with-glidescope-guided-tracheal-intubation-in-children
#15
Bin Zhang, Harshad G Gurnaney, Paul A Stricker, Jorge A Galvez, Rebecca S Isserman, John E Fiadjoe
BACKGROUND: The GlideScope Cobalt is one of the most commonly used videolaryngoscopes in pediatric anesthesia. Although visualization of the airway may be superior to direct laryngoscopy, users need to learn a new indirect way to insert the tracheal tube. Learning this indirect approach requires focused practice and instruction. Identifying the specific points during tube placement, during which clinicians struggle, would help with targeted education. We conducted this prospective observational study to determine the incidence and location of technical difficulties using the GlideScope, the success rates of various corrective maneuvers used, and the impact of technical difficulty on success rate...
May 9, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29749850/identifying-and-remediating-student-misconceptions-in-introductory-biology-via-writing-to-learn-assignments-and-peer-review
#16
Audrey S Halim, Solaire A Finkenstaedt-Quinn, Laura J Olsen, Anne Ruggles Gere, Ginger V Shultz
Student misconceptions are an obstacle in science, technology, engineering, and mathematics courses and unless remediated may continue causing difficulties in learning as students advance in their studies. Writing-to-learn assignments (WTL) are characterized by their ability to promote in-depth conceptual learning by allowing students to explore their understanding of a topic. This study sought to determine whether and what types of misconceptions are elicited by WTL assignments and how the process of peer review and revision leads to remediation or propagation of misconceptions...
June 2018: CBE Life Sciences Education
https://www.readbyqxmd.com/read/29749849/a-faculty-professional-development-model-that-improves-student-learning-encourages-active-learning-instructional-practices-and-works-for-faculty-at-multiple-institutions
#17
Karen N Pelletreau, Jennifer K Knight, Paula P Lemons, Jill S McCourt, John E Merrill, Ross H Nehm, Luanna B Prevost, Mark Urban-Lurain, Michelle K Smith
Helping faculty develop high-quality instruction that positively affects student learning can be complicated by time limitations, a lack of resources, and inexperience using student data to make iterative improvements. We describe a community of 16 faculty from five institutions who overcame these challenges and collaboratively designed, taught, iteratively revised, and published an instructional unit about the potential effect of mutations on DNA replication, transcription, and translation. The unit was taught to more than 2000 students in 18 courses, and student performance improved from preassessment to postassessment in every classroom...
June 2018: CBE Life Sciences Education
https://www.readbyqxmd.com/read/29748952/disentangling-tourette-syndrome-heterogeneity-through-hierarchical-ascendant-clustering
#18
Elena Cravedi, Emmanuelle Deniau, Marianna Giannitelli, Hugues Pellerin, Virginie Czernecki, Tiphanie Priou, Jean Xavier, Angèle Consoli, Andreas Hartmann, David Cohen
AIM: To explore the heterogeneity of Tourette syndrome as part of a neurodevelopmental spectrum. METHOD: Using hierarchical ascendant clustering based on tic symptoms, developmental milestones, and neurodevelopmental comorbidities, we analyzed the heterogeneity of Tourette syndrome phenotypes in a sample of 174 children and adolescents with Tourette syndrome referred to a tertiary university clinic. RESULTS: The model yielded three distinct clusters characterized as follows...
May 10, 2018: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/29747785/critical-care-nurses-experiences-of-performing-successful-peripheral-intravenous-catheterization-in-difficult-situations
#19
Angelica Forsberg, Åsa Engström
The aim of this study is to describe the experiences of critical care nurses (CCNs) when performing successful peripheral intravenous catheterization (PIVC) on adult inpatients in difficult situations. This study uses a descriptive design with a qualitative approach. Semistructured interviews were given to CCNs (n = 22) at a general central county hospital in northern Sweden. The interview text was analyzed with qualitative thematic content analysis. Three themes emerged: "releasing time and creating peace," "feeling self-confidence in the role of expert nurse," and "technical interventions promoting success...
June 2018: Journal of Vascular Nursing: Official Publication of the Society for Peripheral Vascular Nursing
https://www.readbyqxmd.com/read/29747641/the-syrian-conflict-a-case-study-of-the-challenges-and-acute-need-for-medical-humanitarian-operations-for-women-and-children-internally-displaced-persons
#20
Rahma Aburas, Amina Najeeb, Laila Baageel, Tim K Mackey
BACKGROUND: After 7 years of increasing conflict and violence, the Syrian civil war now constitutes the largest displacement crisis in the world, with more than 6 million people who have been internally displaced. Among this already-vulnerable population group, women and children face significant challenges associated with lack of adequate access to maternal and child health (MCH) services, threatening their lives along with their immediate and long-term health outcomes. DISCUSSION: While several health and humanitarian aid organizations are working to improve the health and welfare of internally displaced Syrian women and children, there is an immediate need for local medical humanitarian interventions...
May 11, 2018: BMC Medicine
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