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https://www.readbyqxmd.com/read/28644705/narrative-development-and-supported-employment-of-persons-with-severe-mental-illness
#1
Kelly Ann Cartwright, Tania Lecomte, Marc Corbière, Paul Lysaker
BACKGROUND: While the relationship between objective recovery and work among persons with severe mental illness (SMI) is well-established, few studies have examined the link between subjective recovery and employment. AIMS: The study investigated the prospective relationship between narrative development at the start of supported employment (SE) and positive work outcomes. METHODS: The authors employed a time-limited, mixed-method longitudinal design to examine the relationship between the baseline narrative development of 38 SE participants with SMI and employment outcomes eight months later, as well as whether narratives evolved over the course of the study...
June 23, 2017: Journal of Mental Health
https://www.readbyqxmd.com/read/28644630/expanding-the-therapeutic-potential-of-the-iron-chelator-deferasirox-in-the-development-of-aqueous-stable-ti-iv-anticancer-complexes
#2
Sergio A Loza-Rosas, Alexandra M Vázquez-Salgado, Kennett I Rivero, Lenny J Negrón, Yamixa Delgado, Josué A Benjamín-Rivera, Angel L Vázquez-Maldonado, Timothy B Parks, Charlene Munet-Colón, Arthur D Tinoco
The recent X-ray structure of titanium(IV)-bound human serum transferrin (STf) exhibiting citrate as a synergistic anion reveals a difference in Ti(IV) coordination versus iron(III), the metal endogenously delivered by the protein to cells. This finding enriches our bioinspired drug design strategy for Ti(IV)-based anticancer therapeutics, which applies a family of Fe(III) chelators termed chemical transferrin mimetic (cTfm) ligands to inhibit Fe bioavailability in cancer cells. Deferasirox, a drug used for iron overload disease, is a cTfm ligand that models STf coordination to Fe(III), favoring Fe(III) binding versus Ti(IV)...
June 23, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28644487/-can-diabetes-be-treated-as-an-indirectly-work-related-disease
#3
Andrzej Marcinkiewicz, Anna Radomska, Wojciech Hanke, Jolanta Walusiak-Skorupa
In this article the authors attempted to analyze the arguments for considering diabetes as a work-related disease. An overview of literature has been done out of articles published in the years 1980-2016, with the use of combination of key words referring to employment, workplace, and diabetes. The PubMed database was the source of data. The authors indicate that the following arguments are in favor of diabetes being recognized as a work-related disease: diabetes is not an occupational disease, it is not directly related to the work environment or the way the work is performed, but there are observed adverse effects of occupational work-related nuisances, such as night shift work, long work hours, job strain or workplace standing time, which influence its development and course...
June 22, 2017: Medycyna Pracy
https://www.readbyqxmd.com/read/28644234/efficacy-of-sodium-hyaluronate-in-murine-diabetic-ocular-surface-diseases
#4
Guohu Di, Xia Qi, Xiaowen Zhao, Songmei Zhang, Qingjun Zhou
PURPOSE: To evaluate the efficacy of sodium hyaluronate (HA) eye drops for the treatment of diabetic ocular surface diseases in mice. METHODS: Male 6- to 8-week-old C57BL/6 mice underwent induction of type 1 diabetes with intraperitoneal injections of streptozotocin, with normal mice as the control. Topical 0.3% HA, 0.1% HA, 0.4% polyethylene glycol eye drops, and normal saline were administered to diabetic mice with an intact or debrided corneal epithelium. Normal saline was applied in the controls...
June 21, 2017: Cornea
https://www.readbyqxmd.com/read/28644221/physician-assistant-dual-employment
#5
Colette Jeffery, Dawn Morton-Rias, Mary Rittle, James Cannon, Roderick S Hooker
National health workforce supply and demand models help predict requirements built on individual annual productivity assumptions. Dual employment rarely is addressed, yet in 2015, about 13.5% of certified physician assistants (PAs) reported two or more clinical positions. Of PAs working two positions, 44% reported the main reason was to supplement earnings, followed by role variety. The mean number of hours worked by all certified PAs was 40.7 per week and the average number of patients was 75. Dual-employed PAs averaged more than 51 hours and 97 patients per week...
July 2017: JAAPA: Official Journal of the American Academy of Physician Assistants
https://www.readbyqxmd.com/read/28644196/cebranopadol-a-novel-first-in-class-analgesic-drug-candidate-first-experience-in-patients-with-chronic-low-back-pain-in-a-randomized-clinical-trial
#6
Annette Christoph, Marie-Henriette Eerdekens, Maurits Kok, Gisela Volkers, Rainer Freynhagen
Chronic low back pain (LBP) is a common condition, usually with involvement of nociceptive and neuropathic pain components, high economic burden and impact on quality of life. Cebranopadol is a potent, first-in-class drug candidate with a novel mechanistic approach, combining nociceptin/orphanin FQ peptide and opioid peptide receptor agonism. We conducted the first Phase II, randomized, doubleblind, placebo- and active-controlled trial, evaluating the analgesic efficacy, safety, and tolerability of cebranopadol in patients with moderate to severe chronic LBP with and without neuropathic pain component...
June 21, 2017: Pain
https://www.readbyqxmd.com/read/28643340/trans-endoscopic-diode-laser-fenestration-of-equine-conchae-via-contralateral-nostril-approach
#7
Filip Kološ, Štěpán Bodeček, Zdeněk Žert
OBJECTIVE: To describe and report preliminary outcomes of a contralateral trans-nasal endoscopic laser fenestration of the conchae for endoscopic examination and treatment of paranasal sinuses in horses. STUDY DESIGN: Cadaveric experimental and prospective clinical study. ANIMALS: Normal cadaveric equine heads (n = 7) and equine patients (horses n = 7, donkey n = 1) diagnosed with sinusitis. METHODS: Ex vivo: a video-endoscope containing a diode laser fiber in the working canal was passed through the nostril and retroflexed in the nasopharynx toward the contralateral conchae...
June 23, 2017: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/28641682/health-effects-of-airline-cabin-environments-in-simulated-8-hour-flights
#8
(no author information available yet)
INTRODUCTION: Commercial air travel is usually without health incidents. However, there is a view that cabin environments may be detrimental to health, especially flights of 8 h or more. Concerns have been raised about deep vein thrombosis, upper respiratory tract infections, altitude sickness, and toxins from the engines. METHODS: Passenger cabin simulators were used to achieve a comparative observational study with 8-h flights at pressures equivalent to terrestrial altitudes of ground, 4000, 6000, and 8000 ft...
July 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28641062/the-difficulty-of-being-a-professional-a-parent-and-a-spouse-on-the-same-day-daily-spillover-of-workplace-interactions-on-parenting-and-the-role-of-spousal-support
#9
Kaisa Malinen, Anna Rönkä, Eija Sevón, Dominik Schoebi
Designing parenting interventions and preventions requires knowledge on the factors and processes that shape parenting behaviors. Using data collected over 10 days, during the last hour of work and before going to bed, this study examined the spillover of interpersonal work stresses into positive and negative parenting behaviors. Data were collected among 103 couples who had at least one child between the age of one and eight years. Of particular interest was the role of received emotional spousal support as a moderator of stress spillover...
July 2017: Journal of Prevention & Intervention in the Community
https://www.readbyqxmd.com/read/28640797/rural-and-urban-differences-in-air-quality-2008-2012-and-community-drinking-water-quality-2010-2015-united-states
#10
Heather Strosnider, Caitlin Kennedy, Michele Monti, Fuyuen Yip
PROBLEM/CONDITION: The places in which persons live, work, and play can contribute to the development of adverse health outcomes. Understanding the differences in risk factors in various environments can help to explain differences in the occurrence of these outcomes and can be used to develop public health programs, interventions, and policies. Efforts to characterize urban and rural differences have largely focused on social and demographic characteristics. A paucity of national standardized environmental data has hindered efforts to characterize differences in the physical aspects of urban and rural areas, such as air and water quality...
June 23, 2017: MMWR. Surveillance Summaries: Morbidity and Mortality Weekly Report. Surveillance Summaries
https://www.readbyqxmd.com/read/28640594/biomedical-diagnostics-enabled-by-integrated-organic-and-printed-electronics
#11
Termeh Ahmadraji, Laura Gonzalez-Macia, Tapio Ritvonen, Andreas Willert, Saara Tuurala, Satu Ylimaula, David Donaghy, Mika Suhonen, Dave Smart, Vitaly Efremov, Aoife Morrin, Reinhard R Baumann, Munira Raja, Antti Kemppainen, Anthony J Killard
Organic and printed electronics integration has the potential to revolutionise many technologies, including biomedical diag-nostics. This work demonstrates the successful integration of multiple printed electronic functionalities into a single device capable of the measurement of hydrogen peroxide, and total cholesterol. The single-use device employed printed electrochemical sen-sors for hydrogen peroxide electroreduction integrated with printed electrochromic display and battery. The system was driven by a conventional electronic circuit designed to illustrate the complete integration of silicon ICs via pick and place, or using organic electronic circuits...
June 22, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28640297/preparation-of-tetrazine-containing-2-1-complexes-of-99m-tc-and-in-vivo-targeting-using-bioorthogonal-inverse-electron-demand-diels-alder-chemistry
#12
Abdolreza Yazdani, Nancy Janzen, Shannon Czorny, Robert G Ungard, Tanya Miladinovic, Gurmit Singh, John F Valliant
The aim of this work was to synthesize and evaluate [2 + 1] (99m)Tc(i) polypyridine complexes containing tetrazines, which along with the corresponding Re(i) complexes, represent a new class of isostructural nuclear and turn-on luminescent probes that can be derivatized and targeted using bioorthogonal chemistry. To this end, [2 + 1] complexes of (99m)Tc(i) of the type [(99m)Tc(CO)3(N^N)(L)] (N^N = bathophenanthroline disulfonate (BPS) or 2,2'-bipyridine (bipy)), where the monodentate ligand (L) was a tetrazine linked to the metal through an imidazole derivative, were prepared...
June 22, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28640033/how-attending-physician-preceptors-negotiate-their-complex-work-environment-a-collective-ethnography
#13
Jane B Lemaire, Jean E Wallace, Peter M Sargious, Maria Bacchus, Kelly Zarnke, David R Ward, William A Ghali
PURPOSE: To generate an empiric, detailed, and updated view of the attending physician preceptor role and its interface with the complex work environment. METHOD: In 2013, the authors conducted a modified collective ethnography with observations of internal medicine medical teaching unit preceptors from two university hospitals in Canada. Eleven observers conducted 32 observations (99.5 hours) of 26 preceptors (30 observations [93.5 hours] of 24 preceptors were included in the analysis)...
June 20, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28639916/benefits-of-long-versus-short-thrombolysis-times-for-acutely-thrombosed-hemodialysis-native-fistulas
#14
Susanne Regus, Werner Lang, Marco Heinz, Michael Uder, Axel Schmid
INTRODUCTION: Local thrombolysis with a time of exposure to recombinant tissue plasminogen activator of 15 to 150 minutes is commonly used to declot acutely thrombosed hemodialysis fistulas. The duration of thrombolysis for the restoration of arteriovenous blood flow remains controversial. The aim of this study was to investigate the outcomes of long thrombolysis treatment (LTT, 3 hours or more) and short thrombolysis treatment (STT, less than 3 hours) in our institution. METHODS: We retrospectively analyzed 86 interventional declotting procedures (28 STT and 58 LTT) applied to 86 acutely thrombosed hemodialysis fistulas...
July 2017: Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28638868/in-vivo-effect-of-ruta-chalepensis-extract-on-hepatic-cytochrome-3a1-in-rats
#15
Edith Fabiola Martínez-Pérez, Fernando Hernández-Terán, Luis Benjamín Serrano-Gallardo
BACKGROUND: Since the time when drugs began to be used, it became evident that they could produce a therapeutic effect, but also a clinical condition of toxicity or no effect at all on humans, despite using the same doses in different patients. Such untoward effects were termed "drug idiosyncrasy" and also "idiosyncratic drug effects", but the factors producing such diverse responses were never taken into account. MATERIALS AND METHODS: Ruta chalepensis L. (fringed rue) is an herbaceous plant of the Rutaceae family used in traditional medicine due to its properties, such as its analgesic and antipyretic effects...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28638506/efficacy-of-interventions-to-reduce-resident-physician-burnout-a-systematic-review
#16
REVIEW
Kiran R Busireddy, Jonathan A Miller, Kathleen Ellison, Vicky Ren, Rehan Qayyum, Mukta Panda
BACKGROUND: Studies report high burnout prevalence among resident physicians, with little consensus on methods to effectively reduce it. OBJECTIVE: This systematic literature review explores the efficacy of interventions in reducing resident burnout. METHODS: PubMed, Embase, and Web of Science were searched using these key words: burnout and resident, intern, or residency. We excluded review articles, editorials, letters, and non-English-language articles...
June 2017: Journal of Graduate Medical Education
https://www.readbyqxmd.com/read/28638417/development-and-validation-of-a-decision-making-stratification-algorithm-to-optimize-the-use-of-rapid-diagnostic-testing-for-patients-with-staphylococcus-bacteremia
#17
Thamer A Almangour, Abdullah A Alhifany, Deanne E Tabb
PURPOSE: To evaluate whether introducing rapid diagnostic testing in conjunction with implementing a stratification algorithm for testing eligibility would be an appropriate clinical and cost saving approach. METHOD: An internal concurrent 4-month observational study was performed. Positive blood cultures continued to be worked up in accordance with standard of care. An additional call to the infectious disease (ID) pharmacy service occurred for all positive blood cultures with Gram-positive cocci in clusters (GPCC)...
2017: Canadian Journal of Infectious Diseases & Medical Microbiology
https://www.readbyqxmd.com/read/28637874/direct-demonstration-of-a-neonatal-fc-receptor-fcrn-driven-endosomal-sorting-pathway-for-cellular-recycling-of-albumin
#18
Esben G W Schmidt, Michael L Hvam, Filipa Antunes, Jason Cameron, Dorthe Viuff, Birgitte Andersen, Nanna N Kristensen, Kenneth A Howard
Albumin is the most abundant plasma protein involved in the transport of many compounds, such as fatty acids, bilirubin, and heme. The endothelial cellular neonatal Fc receptor (FcRn) has been suggested to play a central role in maintaining the high albumin plasma levels through a cellular recycling pathway. However, direct mapping of this process is still lacking. This work presents the use of wild type and engineered recombinant albumins with either decreased or increased FcRn affinity in combination with a low or high FcRn-expressing endothelium cell line to clearly define the FcRn involvement, intracellular pathway and kinetics of albumin trafficking by flow cytometry, quantitative confocal microscopy, and an albumin-recycling assay...
June 21, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28637465/early-pulmonary-response-is-critical-for-extra-pulmonary-carbon-nanoparticle-mediated-effects-comparison-of-inhalation-versus-intra-arterial-infusion-exposures-in-mice
#19
Koustav Ganguly, Dariusch Ettehadieh, Swapna Upadhyay, Shinji Takenaka, Thure Adler, Erwin Karg, Fritz Krombach, Wolfgang G Kreyling, Holger Schulz, Otmar Schmid, Tobias Stoeger
BACKGROUND: The death toll associated with inhaled ambient particulate matter (PM) is attributed mainly to cardio-vascular rather than pulmonary effects. However, it is unclear whether the key event for cardiovascular impairment is particle translocation from lung to circulation (direct effect) or indirect effects due to pulmonary particle-cell interactions. In this work, we addressed this issue by exposing healthy mice via inhalation and intra-arterial infusion (IAI) to carbon nanoparticles (CNP) as surrogate for soot, a major constituent of (ultrafine) urban PM...
June 20, 2017: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/28637463/health-and-safety-matters-associations-between-organizational-practices-and-personal-support-workers-life-and-work-stress-in-ontario-canada
#20
Isik U Zeytinoglu, Margaret Denton, Catherine Brookman, Sharon Davies, Firat K Sayin
BACKGROUND: The home and community care sector is one of the fastest growing sectors globally and most prominently in mature industrialized countries. Personal support workers (PSWs) are the largest occupational group in the sector. This paper focuses on the emotional health of PSWs working in the home and community care sector in Ontario, Canada. The purpose of this paper is to present evidence on the associations between PSWs' life and work stress and organizational practices of full-time and guaranteed hours, and PSWs' perceptions of support at work and preference for hours...
June 21, 2017: BMC Health Services Research
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