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https://www.readbyqxmd.com/read/28544997/exposure-to-ultrafine-particles-in-different-transport-modes-in-the-city-of-rome
#1
Mario Grana, Nicola Toschi, Laura Vicentini, Antonio Pietroiusti, Andrea Magrini
There is evidence of adverse health impacts from human exposure to particulate air pollution, including increased rates of respiratory and cardiovascular illness, hospitalizations, and pre-mature mortality. Most recent hypotheses assign an important role to ultrafine particles (UFP) (<0.1 μm) and to associated transition metals (in particular Fe). In a large city like Rome, where many active people spend more than one hour per day in private or public transportation, it may be important to evaluate the level of exposure to harmful pollutants which occurs during urban travelling...
May 22, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28543019/the-burden-of-chronic-spontaneous-urticaria-is-substantial-real-world-evidence-from-assure-csu
#2
Marcus Maurer, Mohamed Abuzakouk, Frédéric Bérard, Walter Canonica, Hanneke Oude Elberink, Ana Giménez-Arnau, Clive Grattan, Kelly Hollis, André Knulst, Jean-Philippe Lacour, Charles Lynde, Alexander Marsland, Doreen McBride, Alla Nakonechna, Javier Ortiz de Frutos, Christina Proctor, Gordon Sussman, Carolyn Sweeney, Haijun Tian, Karsten Weller, Daniel Wolin, Maria-Magdalena Balp
BACKGROUND: Chronic spontaneous urticaria (CSU) can be debilitating, difficult to treat, and frustrating for patients and physicians. Real-world evidence for the burden of CSU is limited. The objective of this study was to document disease duration, treatment history, and disease activity, as well as impact on health-related quality of life (HRQoL) and work among patients with inadequately controlled CSU, and to describe its humanistic, societal, and economic burden. METHODS: This international observational study assessed a cohort of 673 adult patients with CSU whose symptoms persisted for ≥12 months despite treatment...
May 19, 2017: Allergy
https://www.readbyqxmd.com/read/28542636/influence-of-learning-styles-on-the-practical-performance-after-the-four-step-basic-life-support-training-approach-an-observational-cohort-study
#3
Hanna Schröder, Alexandra Henke, Lina Stieger, Stefan Beckers, Henning Biermann, Rolf Rossaint, Saša Sopka
BACKGROUND: Learning and training basic life support (BLS)-especially external chest compressions (ECC) within the BLS-algorithm-are essential resuscitation training for laypersons as well as for health care professionals. The objective of this study was to evaluate the influence of learning styles on the performance of BLS and to identify whether all types of learners are sufficiently addressed by Peyton's four-step approach for BLS training. METHODS: A study group of first-year medical students (n = 334) without previous medical knowledge was categorized according to learning styles using the German Lernstilinventar questionnaire based on Kolb's Learning Styles Inventory...
2017: PloS One
https://www.readbyqxmd.com/read/28542562/identification-and-characteristics-of-extracellular-vesicles-from-bovine-blastocysts-produced-in-vitro
#4
Edwin A Mellisho, Alejandra E Velásquez, María J Nuñez, Joel G Cabezas, Juan A Cueto, Claudio Fader, Fidel O Castro, Lleretny Rodríguez-Álvarez
Extracellular vesicles (EVs) have been identified within different body fluids and cell culture media. However, there is very little information on the secretion of these vesicles during early embryonic development. The aims of this work were first to demonstrate the secretion of extracellular vesicles by pre-implantation bovine embryos and second to identify and characterize the population of EVs secreted by bovine blastocysts during the period from day seven to nine of embryo culture and its correlation with further embryo development up to day 11...
2017: PloS One
https://www.readbyqxmd.com/read/28542202/unravelling-the-rate-of-action-of-hits-in-the-leishmania-donovani-box-using-standard-drugs-amphotericin-b-and-miltefosine
#5
Diana Tegazzini, Juan Cantizani, Imanol Peña, Julio Martín, Jose M Coterón
In recent years, the neglected diseases drug discovery community has elected phenotypic screening as the key approach for the identification of novel hit compounds. However, when this approach is applied, important questions related to the mode of action for these compounds remain unanswered. One of such questions is related to the rate of action, a useful piece of information when facing the challenge of prioritising the most promising hit compounds. In the present work, compounds of the "Leishmania donovani box" were evaluated using a rate of action assay adapted from a replicative intracellular high content assay recently developed...
May 25, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28542020/ciclovia-in-a-rural-latino-community-results-and-lessons-learned
#6
Cynthia K Perry, Linda K Ko, Lidia Hernandez, Rosa Ortiz, Sandra Linde
CONTEXT: Ciclovias involve the temporary closure of roads to motorized vehicles, allowing for use by bicyclists, walkers, and runners and for other physical activity. Ciclovias have been held in urban and suburban communities in the United States and Latin America. OBJECTIVE: We evaluated the first ciclovia held in a rural, predominantly Latino community in Washington State. SETTING: Three blocks within a downtown area in a rural community were closed for 5 hours on a Saturday in July 2015...
July 2017: Journal of Public Health Management and Practice: JPHMP
https://www.readbyqxmd.com/read/28541436/changes-in-sleep-duration-during-transition-to-statutory-retirement-a-longitudinal-cohort-study
#7
Saana Myllyntausta, Paula Salo, Erkki Kronholm, Ville Aalto, Mika Kivimäki, Jussi Vahtera, Sari Stenholm
Study Objectives: This study examined whether sleep duration changes during the transition from full-time work to statutory retirement and, if this were the case, which pre-retirement factors, including sociodemographic, work, lifestyle and health factors, predict these changes. Methods: Data from repeated surveys of the Finnish Public Sector study, linked to records of retirement, were used. The study population consisted of 5,785 participants who retired on a statutory basis in 2000-2011 and who had responded to surveys on sleep duration at least once immediately before and after their retirement (mean number of repeat study waves 3...
May 24, 2017: Sleep
https://www.readbyqxmd.com/read/28541149/characterization-of-equine-vitamin-d-binding-protein-development-of-an-assay-and-assessment-of-plasma-concentrations-of-the-protein-in-healthy-horses-and-horses-with-gastrointestinal-disease
#8
Tina H Pihl, Stine Jacobsen, Dorthe T Olsen, Peter Højrup, Astrid Grosche, David E Freeman, Pia H Andersen, Gunnar Houen
OBJECTIVE To purify and characterize equine vitamin D-binding protein (VDBP) from equine serum and to evaluate plasma concentrations of VDBP in healthy horses and horses with gastrointestinal injury or disease. ANIMALS 13 healthy laboratory animals (8 mice and 5 rabbits), 61 healthy horses, 12 horses with experimentally induced intestinal ischemia and reperfusion (IR), and 59 horses with acute gastrointestinal diseases. PROCEDURES VDBP was purified from serum of 2 healthy horses, and recombinant equine VDBP was obtained through a commercial service...
June 2017: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/28540115/the-benefits-of-streamlined-hip-fracture-management-in-a-regional-hospital
#9
T C Mow, Jen Lukeis, A G Sutherland
INTRODUCTION: Hip fracture is an increasingly common injury in the growing elderly population. The morbidity and mortality associated with this injury can be reduced by minimizing delays to surgical treatment. We describe the impact of a regional hospital service redesign project that utilized the principles of smart simplicity, a management strategy that lays emphasis on collaboration to achieve desired goals. METHODS: Prior to the redesign, patients with hip fractures were taking an average of 72 hours for surgical treatment...
June 2017: Geriatric Orthopaedic Surgery & Rehabilitation
https://www.readbyqxmd.com/read/28539538/exhausting-physicians-employed-in-hospitals-in-japan-assessed-by-a-health-questionnaire
#10
Shosuke Suzuki
OBJECTIVE: Japanese physicians employed and working in general hospitals have become busier since 2005, as they had to teach and guide the increased number of medical residents graduated from medical schools. Working hours and chronic fatigue of employed physicians were surveyed compared with independent physicians working in their own out-patient clinics and with usual employed men in Japan, and their mental health was assessed. METHODS: (1) 75 employed physicians in hospitals were surveyed of their working hours a week and compared with (2) 48 independent general practitioners (GP) who work in their own out-patient clinics...
May 25, 2017: Sangyō Eiseigaku Zasshi, Journal of Occupational Health
https://www.readbyqxmd.com/read/28539188/counterbalancing-work-related-stress-work-engagement-among-intensive-care-professionals
#11
Margo M C van Mol, Marjan D Nijkamp, Jan Bakker, Wilmar B Schaufeli, Erwin J O Kompanje
BACKGROUND AND OBJECTIVES: Working in an Intensive Care Unit (ICU) is increasingly complex and is also physically, cognitively and emotionally demanding. Although the negative emotions of work-related stress have been well studied, the opposite perspective of work engagement might also provide valuable insight into how these emotional demands may be countered. This study focused on the work engagement of ICU professionals and explored the complex relationship between work engagement, job demands and advantageous personal resources...
May 20, 2017: Australian Critical Care: Official Journal of the Confederation of Australian Critical Care Nurses
https://www.readbyqxmd.com/read/28539167/what-do-working-menopausal-women-want-a-qualitative-investigation-into-women-s-perspectives-on-employer-and-line-manager-support
#12
Claire Hardy, Amanda Griffiths, Myra S Hunter
OBJECTIVES: To explore women's perspectives on what employers and managers should and should not do in relation to women going through the menopause. METHODS: An online questionnaire was used to collect qualitative data in a cross-sectional study of working women. Three open-ended questions asked peri- and post-menopausal women, aged 45-65 years: (i) what they thought employers could do, or should do, to help menopausal women who may be experiencing difficult menopausal symptoms at work; (ii) how managers should behave; and (iii) how managers should not behave towards women going through the menopause...
July 2017: Maturitas
https://www.readbyqxmd.com/read/28539147/sunlight-exposure-work-hours-caffeine-consumption-and-sleep-duration-in-the-naval-environment
#13
Nita L Shattuck, Panagiotis Matsangas
BACKGROUND: Sailors in the U.S. Navy are habitual shiftworkers, often experiencing circadian misalignment due to their irregular work/rest schedules. This study assessed the effect of sunlight exposure, work hours, and caffeinated beverage consumption on the daily sleep duration of crewmembers of a U.S. Navy ship during a 2-wk underway period. METHODS: Working in an artificially lit area with no access to sunlight during work hours, U.S. Navy crew members (N = 91) used daily logs to report their daily activity, caffeinated beverage consumption, and exposure to sunlight while off-duty; sleep was assessed by wrist-worn actigraphy...
June 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28538018/low-serum-angiopoietin-1-high-serum-angiopoietin-2-and-high-ang-2-ang-1-protein-ratio-are-associated-with-early-onset-sepsis-in-surinamese-newborns
#14
Rens Zonneveld, Rianne Jongman, Amadu Juliana, Wilco Zijlmans, Frans Plötz, Grietje Molema, Matijs van Meurs
PURPOSE: Vascular inflammation and leakage in sepsis is mediated by Angiopoietin-1 (Ang-1) and -2 (Ang-2) and their phosphorylation of the endothelial Tie-2 receptor. Levels of Ang-2 change in adults and children during sepsis, which is associated with severity of sepsis. This study investigates levels of Ang-1 and Ang-2 in newborns to gain insight in the vascular pathophysiology of early onset sepsis (EOS) within 72 hours after birth. METHODS: A prospective cohort study was performed amongst 71 Surinamese newborns treated with antibiotics for suspected EOS and 20 control newborns...
May 22, 2017: Shock
https://www.readbyqxmd.com/read/28537950/factors-associated-with-success-of-clinician-researchers-receiving-career-development-awards-from-the-national-institutes-of-health-a-longitudinal-cohort-study
#15
Reshma Jagsi, Kent A Griffith, Rochelle D Jones, Abigail Stewart, Peter A Ubel
PURPOSE: Understanding the careers of recent career development awardees is essential to guide interventions to ensure gender equity and success in academic medicine. METHOD: In 2010-2011 (T1) and 2014 (T2), 1,719 clinician-researchers who received new K08 and K23 awards in 2006-2009 were longitudinally surveyed. Multivariable analyses evaluated the influence of factors on success, including demographics, job characteristics, work environment, priorities, and domestic responsibilities...
May 23, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28537765/factors-associated-with-sleep-duration-in-brazilian-high-school-students
#16
Érico Pereira Gomes Felden, Diego Grasel Barbosa, Geraldo Jose Ferrari Junior, Manoella De Oliveira Santos, Andreia Pelegrini, Diego Augusto Santos Silva
The aim of this study was to investigate the factors associated with short sleep duration on southern Brazilian high school students. Our study was comprised of 1,132 adolescents aged 14 to 19 years, enrolled in public high schools in São José, Brazil. The students answered a questionnaire about working (work and workload), health perception, smoking, school schedule, sleep (duration and daytime sleepiness), and socio-demographics data. The results showed that more than two thirds of adolescent workers had short sleep duration (76...
May 24, 2017: Chronobiology International
https://www.readbyqxmd.com/read/28537388/micro-electric-current-treatment-enhanced-biodegradation-of-pumpkin-lignocelluloses-by-trichoderma-reesei-rut-c30
#17
Rui Yang, Yuqian Liu, Zhongkai Zhou, Jiping Sheng, Demei Meng
A home-made micro-current reactor was used to treat the fermentation of Trichoderma reesei. Results indicated that the yield of saccharides for Trichoderma reesei RUT-C30 cultivated in pumpkin lignocelluloses broth reach to 38.86% (w/w), when a micro-current treatment (20 mA, at 48th hour for 60 min) was carried out, which is significantly higher than the control group (p<0.05). Additionally, activities of endoglucanase, cellobiohydrolase, xylanase, and pectinase were significantly increased in days 3-7...
May 24, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28537201/capturing-sexual-assault-data
#18
S Aqif Mukhtar, Debbie A Smith, Maureen A Phillips, Maire C Kelly, Renate R Zilkens, James B Semmens
BACKGROUND: The Sexual Assault Resource Center (SARC) in Perth, Western Australia provides free 24-hour medical, forensic, and counseling services to persons aged over 13 years following sexual assault. OBJECTIVE: The aim of this research was to design a data management system that maintains accurate quality information on all sexual assault cases referred to SARC, facilitating audit and peer-reviewed research. METHODS: The work to develop SARC Medical Services Clinical Information System (SARC-MSCIS) took place during 2007-2009 as a collaboration between SARC and Curtin University, Perth, Western Australia...
January 1, 2017: HIM Journal
https://www.readbyqxmd.com/read/28535713/the-relationship-between-shiftwork-and-violence-against-nurses-a-case-control-study
#19
Steve Sun, Susan Goodwin Gerberich, Andrew D Ryan
This study investigated the potential relationship between shiftwork and work-related physical assault (PA) against nurses who are at high risk of violence globally. Nurses (6,300), randomly selected from the licensing database and working in Minnesota, were surveyed regarding PA experiences. Through a nested case-control study, nurses who reported a PA in the previous 12 months and controls who were randomly selected from their assault-free working months, respectively, identified exposures experienced during the month prior to the assault month (cases) and the random non-PA months (controls)...
May 1, 2017: Workplace Health & Safety
https://www.readbyqxmd.com/read/28535416/the-role-of-timing-in-the-treatment-of-spinal-cord-injury
#20
REVIEW
Amene Saghazadeh, Nima Rezaei
Regeneration failure after primary spinal cord injury (SCI) leads to diverse clinical complications in a severity- and level of SCI-dependent manner. The cost of treating both of them (initial regeneration failure and following complications) would be prohibitive, particularly in less developed nations. The well-recognized circumstances arose from primary SCI include excitotoxicity and inflammation. SCI increases concentrations of extracellular amino acids (EAAs) in the severity-dependent manner and the maximum level of EAAs at the injury site will be reduced by distance from the injury site...
May 20, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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