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Folliculotropic mycosis fungoides

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https://www.readbyqxmd.com/read/27904177/a-clinicopathological-analysis-of-primary-cutaneous-lymphomas-a-6-year-observational-study-at-a-tertiary-care-center-of-south-india
#1
Anza Khader, Shiny Padinjarayil Manakkad, Mohammed Shaan, Sarita Sasidharan Pillai, Najeeba Riyaz, P Binitha Manikoth, Muhammed Kunnummel, Sunitha Balakrishnan
BACKGROUND: Little data are available concerning clinical and pathological patterns of cutaneous lymphomas in India. AIM: To analyze the clinical and histopathological characteristics of cutaneous lymphomas in Indian patients. MATERIALS AND METHODS: This is a single-center, prospective, observational study carried out from January 1, 2010, to December 31, 2015. The patients underwent clinical examination, human T-cell lymphotropic virus-1 (HTLV-1) screening, skin biopsy with hematoxylin and eosin and immunohistochemistry staining...
November 2016: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/27868149/topical-carmustine-as-monotherapy-or-as-multimodality-therapy-for-folliculotropic-mycosis-fungoides
#2
Kelly M MacArthur, Neha Jariwala, Ellen J Kim, Alain H Rook
is missing (Short communication).
October 14, 2016: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/27688448/folliculotropic-mycosis-fungoides-clinical-and-histologic-features-in-five-patients
#3
Amir Hooshang Ehsani, Arghavan Azizpour, Pedram Noormohammadpoor, Hasan Seirafi, Farshad Farnaghi, Kambiz Kamyab-Hesari, Mehdi Sharifi, Maryam Nasimi
BACKGROUND: Alopecia can be a manifestation of mycosis fungoides (MF); however, the prevalence is unknown. AIMS: We sought to describe the clinicopathologic presentation of alopecia in patients with diagnosis of MF. METHODS: A retrospective analysis of patients with biopsy-proven MF, who were evaluated at our cancer center from 2002 to 2012, was performed to identify patients with alopecia. RESULTS: Five patients with alopecia were identified from reviewing of 157 patients with MF...
September 2016: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/27637428/clinical-efficacy-of-romidepsin-in-tumor-stage-and-folliculotropic-mycosis-fungoides
#4
Francine Foss, Madeleine Duvic, Adam Lerner, Joel Waksman, Sean Whittaker
BACKGROUND: Tumor stage and folliculotropic mycosis fungoides are uncommon subtypes of cutaneous T-cell lymphoma (CTCL) with an aggressive disease course. Romidepsin is a histone deacetylase inhibitor approved by the US Food and Drug Administration for patients with CTCL who have received ≥ 1 previous systemic therapy. In the present study, we examined the efficacy and safety of romidepsin in patients from the pivotal, single-arm, open-label, phase II study of relapsed or refractory CTCL with cutaneous tumors and/or folliculotropic disease involvement...
August 10, 2016: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/27552962/prognostic-indicators-for-mycosis-fungoides-in-a-greek-population
#5
V Nikolaou, E Papadavid, A Patsatsi, M Siakantaris, A Economidi, L Marinos, T Koletsa, E Georgiou, V Pappa, A Stratigos, C Antoniou
BACKGROUND: Mycosis fungoides (MF) is an indolent cutaneous lymphoma with excellent prognosis at early stages and much poorer outcome during disease progression. Old age, male sex and folliculotropism have been proposed as relevant prognostic factors, however, their exact effect remains debatable. OBJECTIVE: To evaluate MF prognostic indicators and survival rates in a Greek population. METHODS: Prognostic variables effecting survival rates were studied in 473 MF patients diagnosed and treated by two academic referral centers in Greece...
August 24, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27546732/cd8-mycosis-fungoides-clinically-masquerading-as-alopecia-areata
#6
Sapna M Amin, Timothy Tan, Joan Guitart, Maria Colavincenzo, Pedram Gerami, Pedram Yazdan
A 33-year-old female with a 7-year history of CD8-positive hypopigmented mycosis fungoides (MF) involving the trunk and extremities presented with a large well-defined alopecic patch on her frontal scalp. Clinically, this area resembled alopecia areata (AA) and was without hypopigmentation or erythema. A scalp biopsy revealed a non-scarring inflammatory alopecia and a superficial band-like atypical lymphoid infiltrate with prominent epidermotropism. Atypical, predominately CD8-positive lymphocytes were seen surrounding and infiltrating the bulb portion of several hair follicles...
December 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27512205/folliculotropic-mycosis-fungoides-in-an-adolescent-a-rare-case
#7
Meeta Dipak Mantri, Mona P Khadke, Dandale L Ameet, Dhurat S Rachita
Folliculotropic mycosis fungoides (FMF) is an uncommon and aggressive form of mycoses fungoides with preferential involvement of head and neck region. Lesions of FMF present as erythematous plaques or papules with follicular prominences, acneiform lesions, cysts, nodules, patches of scarring alopecia, and prurigo-like lesions. The mean age of diagnosis is at 60 years and it is extremely rare in childhood and adolescence. We report a case of a 16-year-old male patient who presented with a 2-month history of an asymptomatic erythematous infiltrated plaque over the forehead...
July 2016: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/27477179/folliculotropic-cutaneous-metastases-and-lymphangitis-carcinomatosa-when-cutaneous-metastases-of-breast-carcinoma-are-mistaken-for-cutaneous-infections
#8
Giovanni Paolino, Chiara Panetta, Dario Didona, Michele Donati, Pietro Donati
Dear Editor, Cutaneous metastases (CM) are detected in about 0.6-10.4% of patients with an internal malignancy (1-3). Excluding melanoma, breast and lung carcinomas are the main source of CM in women and men, respectively (1,4,5). CM can have different clinical features, and a diagnosis of CM is usually suspected before performing a biopsy. However, this can be a pitfall for clinicians when the clinical presentation is not the typical inflammatory nodule or mass. Herein we report 2 cases of cutaneous metastases of breast carcinoma, initially treated as a common skin infection...
June 2016: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/27473081/genomic-imbalances-and-microrna-transcriptional-profiles-in-patients-with-mycosis-fungoides
#9
Fuad Huaman Garaicoa, Alejandro Roisman, Mariana Arias, Carla Trila, Miguel Fridmanis, Alejandra Abeldaño, Silvia Vanzulli, Marina Narbaitz, Irma Slavutsky
Mycosis fungoides is the most common type of primary cutaneous T cell lymphoma. We have evaluated CDKN2A losses and MYC gains/amplifications by FISH analysis, as well as expression of miR-155 and members of the oncogenic cluster miR-17-92 (miR17, miR18a, miR19b, and miR92a) in MF patients with advanced disease. Formalin-fixed paraffin-embedded skin biopsies from 36 patients at diagnosis, 16 with tumoral MF (T-MF), 13 in histological transformation to a large T cell lymphoma (TR-MF), and 7 cases with folliculotropic variant (F-MF), were studied...
October 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/27276223/clinical-staging-and-prognostic-factors-in-folliculotropic-mycosis-fungoides
#10
Suzanne van Santen, Rachel E J Roach, Remco van Doorn, Barbara Horváth, Marjolein S Bruijn, Cornelus J G Sanders, Jacco C de Pooter, Michelle M van Rossum, Ellen R M de Haas, Joep C J M Veraart, Marcel W Bekkenk, Maarten H Vermeer, Rein Willemze
IMPORTANCE: Large case series suggest that patients with folliculotropic mycosis fungoides (FMF) have a worse prognosis than patients with classic mycosis fungoides (MF). However, recent studies described a subgroup of patients with FMF with a more favorable prognosis. Distinction between indolent and aggressive FMF may have important therapeutic consequences but is hampered by the inability of the current tumor-node-metastasis-blood (TNMB) staging system to classify patients with FMF in a clinically meaningful way...
September 1, 2016: JAMA Dermatology
https://www.readbyqxmd.com/read/27245278/new-insights-into-folliculotropic-mycosis-fungoides-fmf-a-single-center-experience
#11
Emmilia Hodak, Iris Amitay-Laish, Lihi Atzmony, Hadas Prag-Naveh, Natalia Yanichkin, Aviv Barzilai, Ruben Kershenovich, Meora Feinmesser
BACKGROUND: It is generally accepted that folliculotropic mycosis fungoides (FMF) is usually typified by indurated plaques and tumors mainly on the head/neck and an aggressive course. However, its clinical manifestations have long been recognized to be quite variable, and some studies indicate a better prognosis for certain presentations. OBJECTIVE: We sought to summarize our experience with the clinicopathological presentations of FMF and impact on prognosis. METHODS: Data were collected retrospectively for adults with FMF followed up prospectively at a tertiary medical center in 1995 through 2014...
August 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27104864/validation-of-cutaneous-lymphoma-international-prognostic-index-clipi-for-mycosis-fungoides-and-s%C3%A3-zary-syndrome
#12
Hasan H Danish, Shuling Liu, Jaymin Jhaveri, Christopher R Flowers, Mary J Lechowicz, Natia Esiashvili, Mohammad K Khan
We sought to evaluate the performance of the cutaneous lymphoma international prognostic index (CLIPI), a prognostic index for mycosis fungoides (MF), and Sézary syndrome (SS), in our cohort of patients seen at Emory University between 1998 and 2013. Additionally, we examined the prognostic significance of lactate dehydrogenase (LDH), B0a/b, and CD30 status. A total of 390 patients were included in analysis: 78.2% early stage (IA-IIA), 7.2% with SS, 53.1% male, mean age 53.5 years. CLIPI stratified patients into low, intermediate, and high-risk groups for overall survival (OS) and progression free survival (PFS) for early stage patients (p < 0...
April 22, 2016: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/27051776/clearance-of-folliculotropic-and-tumor-mycosis-fungoides-with-topical-5-imiquimod
#13
Matthew C Gordon, Jason C Sluzevich, Anokhi Jambusaria-Pahlajani
No abstract text is available yet for this article.
November 2015: JAAD Case Reports
https://www.readbyqxmd.com/read/26730698/follicular-lymphomatoid-papulosis-an-eosinophilic-rich-follicular-subtype-masquerading-as-folliculitis-clinically-and-histologically
#14
REVIEW
Nicholas A Ross, Hong Truong, Matthew S Keller, John K Mulholland, Jason B Lee, Joya Sahu
Lymphomatoid papulosis (LyP) is an uncommon CD30 lymphoproliferative disorder with a relatively excellent prognosis. Ten to twenty percent of cases, however, are associated with a lymphoma, typically systemic or cutaneous anaplastic large cell lymphoma, mycosis fungoides, or Hodgkin lymphoma. Subtypes divide LyP into infiltrate-descriptive categories along a spectrum of histological manifestation. Classically, LyP shows a patchy, wedge-shaped, perivascular dermal infiltrate of small- to intermediate-sized lymphoid cells, larger lymphoid, with one, 2, or multiple prominent nucleoli, and a variable admixture of neutrophils, eosinophils, and histiocytes...
January 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/26711732/folliculotropic-mycosis-fungoides-clinical-and-epidemiological-evaluation-in-a-single-center-in-brazil
#15
Janyana M D Deonizio, Rogers Diego Ascef, José Antonio Sanches
BACKGROUND: Folliculotropic mycosis fungoides (FMF) is a rare variant of mycosis fungoides with clinical peculiarities, refractoriness to conventional treatments, and worse prognosis when compared to classic mycosis fungoides. OBJECTIVE: To evaluate the clinical and epidemiological characteristics of FMF patients in a single center in Brazil. METHODS: Data were retrospectively collected from patients with FMF who attended the Cutaneous Lymphoma Clinic, University of São Paulo Medical School, between 1987 and 2013...
May 2016: International Journal of Dermatology
https://www.readbyqxmd.com/read/26476898/leonine-facies-lf-and-mycosis-fungoides-mf-a-single-center-study-and-systematic-review-of-the-literature
#16
REVIEW
Danielle Nicole Brown, Iris Wieser, Casey Wang, Boutnaina S Dabaja, Madeleine Duvic
BACKGROUND: Leonine facies (LF) is defined as displaying facial features similar to that of a lion with prominent convexities and furrowed creases. LF develops in a very small population of patients with cutaneous T-cell lymphoma. OBJECTIVE: We aimed to study the clinicopathologic features and overall prognosis associated with LF in patients with mycosis fungoides and Sézary syndrome. METHODS: We conducted a single-center retrospective study, reviewing 1338 patients with mycosis fungoides seen from 1987 to 2015 at a tertiary referral center for cutaneous T-cell lymphoma, and a systematic review of 14 patients in the literature...
December 2015: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/26438120/cutaneous-lymphoma-international-consortium-study-of-outcome-in-advanced-stages-of-mycosis-fungoides-and-s%C3%A3-zary-syndrome-effect-of-specific-prognostic-markers-on-survival-and-development-of-a-prognostic-model
#17
Julia J Scarisbrick, H Miles Prince, Maarten H Vermeer, Pietro Quaglino, Steven Horwitz, Pierluigi Porcu, Rudolf Stadler, Gary S Wood, Marie Beylot-Barry, Anne Pham-Ledard, Francine Foss, Michael Girardi, Martine Bagot, Laurence Michel, Maxime Battistella, Joan Guitart, Timothy M Kuzel, Maria Estela Martinez-Escala, Teresa Estrach, Evangelia Papadavid, Christina Antoniou, Dimitis Rigopoulos, Vassilki Nikolaou, Makoto Sugaya, Tomomitsu Miyagaki, Robert Gniadecki, José Antonio Sanches, Jade Cury-Martins, Denis Miyashiro, Octavio Servitje, Cristina Muniesa, Emilio Berti, Francesco Onida, Laura Corti, Emilia Hodak, Iris Amitay-Laish, Pablo L Ortiz-Romero, Jose L Rodríguez-Peralto, Robert Knobler, Stefanie Porkert, Wolfgang Bauer, Nicola Pimpinelli, Vieri Grandi, Richard Cowan, Alain Rook, Ellen Kim, Alessandro Pileri, Annalisa Patrizi, Ramon M Pujol, Henry Wong, Kelly Tyler, Rene Stranzenbach, Christiane Querfeld, Paolo Fava, Milena Maule, Rein Willemze, Felicity Evison, Stephen Morris, Robert Twigger, Rakhshandra Talpur, Jinah Kim, Grant Ognibene, Shufeng Li, Mahkam Tavallaee, Richard T Hoppe, Madeleine Duvic, Sean J Whittaker, Youn H Kim
PURPOSE: Advanced-stage mycosis fungoides (MF; stage IIB to IV) and Sézary syndrome (SS) are aggressive lymphomas with a median survival of 1 to 5 years. Clinical management is stage based; however, there is wide range of outcome within stages. Published prognostic studies in MF/SS have been single-center trials. Because of the rarity of MF/SS, only a large collaboration would power a study to identify independent prognostic markers. PATIENTS AND METHODS: Literature review identified the following 10 candidate markers: stage, age, sex, cutaneous histologic features of folliculotropism, CD30 positivity, proliferation index, large-cell transformation, WBC/lymphocyte count, serum lactate dehydrogenase, and identical T-cell clone in blood and skin...
November 10, 2015: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/26370648/alopecias-due-to-drugs-and-other-skin-and-systemic-disorders
#18
REVIEW
Daniela Guzmán-Sánchez, Daniel Asz-Sigall
In this chapter, we will discuss the most common alopecias due to drugs and other skin and systemic disorders. The following hair disorders will be analyzed: telogen effluvium (acute and chronic); anagen effluvium; folliculotropic mycosis fungoides; and folliculitis due to bacteria, fungi, parasites, human immunodeficiency virus disease, lupus erythematosus, and sarcoidosis. We will cover topics including the epidemiology, etiology, clinical picture, and diagnosis of and current treatments for each disease.
2015: Current Problems in Dermatology
https://www.readbyqxmd.com/read/26288459/non-folliculotropic-milia-in-a-treated-case-of-mycosis-fungoides-a-rare-occurrence
#19
Tatsuhiko Mori, Mikio Ohtsuka, Yuka Hanami, Toshiyuki Yamamoto
No abstract text is available yet for this article.
July 2015: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/26283779/folliculotropic-mycosis-fungoides-as-a-posttransplant-lymphoproliferative-disorder
#20
Allyson Spence-Shishido, Jenna L Streicher, Roshan P George, Sareeta R Parker, Leslie P Lawley
Posttransplant lymphoproliferative disorder (PTLD) is a known complication of solid organ transplantation. The majority are B cell in origin and related to Epstein-Barr virus infection. T-cell PTLD is much less common; most are Epstein-Barr virus negative and have a worse prognosis. Primary cutaneous T-cell lymphoma (CTCL) as a presentation of PTLD is rare. CTCL has a less favorable prognosis in transplant patients compared with that in immune-competent patients. Herein, we report a case of a 13-year-old boy who developed folliculotropic mycosis fungoides, a rare subtype of CTCL, subsequent to renal transplantation...
September 2015: Pediatrics
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