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Disseminated histoplasmosis

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https://www.readbyqxmd.com/read/29433397/hemophagocytic-lymphohistiocytosis-in-an-hiv-positive-patient-with-concomitant-disseminated-histoplasmosis
#1
Nisha Loganantharaj, Brianna Oliver, Taylor Smith, Rachna Jetly, Lee Engel, Shane Sanne
A 46-year-old Dominican man, known to have HIV, presented with constitutional symptoms of two week's duration. The patient was found to have cytopenias, significantly elevated ferritin level and lymphadenopathy. Biopsies and laboratory studies met the criteria for hemophagocytic lymphohistiocytosis (HLH). A concomitant diagnosis of histoplasmosis was confirmed as the trigger for HLH and treatment resulted in clinical improvement and resolution of symptoms.
January 1, 2018: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/29429549/mucocutaneous-manifestations-of-infection-by-histoplasma-capsulatum-in-hiv-negative-immunosuppressed-patients
#2
L V Gómez-Santana, A C Torre, B A Hernández, V I Volonteri, B Laura, R Luis-Galimberti
Histoplasmosis is a systemic mycosis caused by the dimorphous fungus Histoplasma capsulatum (H. capsulatum). The fungus enters the body through the respiratory tract in the form of microconidia, which are transformed into intracellular yeast-like structures in the lungs before disseminating hematogenously. Primary infection is usually asymptomatic and self-resolving. Some patients develop severe disease with acute or chronic respiratory involvement. Immunosuppressed patients, mainly those with altered cellular immunity, may have disseminated disease with variable mucocutaneous involvement characterized by papules, nodules, gummas, or ulcers with a granulomatous base...
February 8, 2018: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/29379705/the-important-role-of-co-infections-in-patients-with-aids-and-progressive-disseminated-histoplasmosis-pdh-a-cohort-from-colombia
#3
Diego H Caceres, Ángela M Tobón, Ángela Restrepo, Tom Chiller, Beatriz L Gómez
A total of 23/45 (51%) patients with AIDS and histoplasmosis from Medellín, Colombia had other infections. Tuberculosis was the most common (n = 16/23, 70%). Pneumocystosis and cryptococcosis were found in three patients each (13%), bacterial infection and cytomegalovirus occurred each in two patients (9%) while toxoplasmosis, herpes virus and esophageal candidiasis were recorded in one patient each (4%). Of all co-infected patients, 18/23 (78%) had one, four (17%) had two and one (4%) had three additional opportunistic infections...
March 2018: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/29375836/unexpected-disseminated-histoplasmosis-detected-by-bone-marrow-biopsy-in-a-solid-organ-transplant-patient
#4
Caroline T Simon, Carlos A Murga-Zamalloa, Michael A Bachman, Lindsay A Petty, Sarah M Choi
Disseminated histoplasmosis and hemophagocytic lymphohistiocytosis show overlapping features, which require careful contextual interpretation. Histopathologic evaluation can potentially rapidly identify cases of possible histoplasmosis. A high index of clinical suspicion, particularly in endemic areas and in a setting of immunosuppression, is critical to appropriate diagnosis and treatment.
January 2018: Clinical Case Reports
https://www.readbyqxmd.com/read/29371573/global-and-multi-national-prevalence-of-fungal-diseases-estimate-precision
#5
REVIEW
Felix Bongomin, Sara Gago, Rita O Oladele, David W Denning
Fungal diseases kill more than 1.5 million and affect over a billion people. However, they are still a neglected topic by public health authorities even though most deaths from fungal diseases are avoidable. Serious fungal infections occur as a consequence of other health problems including asthma, AIDS, cancer, organ transplantation and corticosteroid therapies. Early accurate diagnosis allows prompt antifungal therapy; however this is often delayed or unavailable leading to death, serious chronic illness or blindness...
October 18, 2017: Journal of Fungi (Basel, Switzerland)
https://www.readbyqxmd.com/read/29348388/disseminated-histoplasmosis-in-an-indonesian-hiv-positive-patient-a-case-diagnosed-by-fine-needle-aspiration-cytology
#6
Nungki Anggorowati, Rita C Sulistyaningsih, Ahmad Ghozali, Yanri W Subronto
A 30-year-old Javanese-Indonesian man was admitted with complaints of 3 months persistent fever, weight loss, and fatigue. He had never known his past history of unprotected HIV until the admission. His only risk factor is unsafe sex. The patient seemed well nourished. Physical examination revealed blood pressure 100/60 mmHg, pulse 100 beats per minute, respiratory rate 20 times per minute, and temperature 38.8°C. Multiple cervical and inguinal lymphadenopathies were also found. Electrocardiogram showed anterolateral ischemic finding, whereas chest X-ray were normal...
October 2017: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/29346384/histoplasmosis-in-africa-an-emerging-or-a-neglected-disease
#7
REVIEW
Rita O Oladele, Olusola O Ayanlowo, Malcolm D Richardson, David W Denning
Histoplasmosis in Africa has markedly increased since the advent of the HIV/AIDS epidemic but is under-recognised. Pulmonary histoplasmosis may be misdiagnosed as tuberculosis (TB). In the last six decades (1952-2017), 470 cases of histoplasmosis have been reported. HIV-infected patients accounted for 38% (178) of the cases. West Africa had the highest number of recorded cases with 179; the majority (162 cases) were caused by Histoplasma capsulatum var. dubuosii (Hcd). From the Southern African region, 150 cases have been reported, and the majority (119) were caused by H...
January 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29340926/gastrointestinal-histoplasmosis-ileal-stricture-successfully-treated-with-through-the-scope-balloon-dilation-in-a-patient-with-hyperimmunoglobulin-m-syndrome
#8
Fredy Nehme, Kyle Rowe, Mohamad El Hawari, Maha Assi, Imad Nassif
Gastrointestinal histoplasmosis is common in patients with disseminated disease affecting both immunocompetent and immunocompromised patients. However, it is often unrecognized due to a lack of specific signs and symptoms. It has only rarely been reported to cause small bowel obstruction, during which surgical treatment was nearly always necessary. Little is known about the usefulness of endoscopic therapy in gastrointestinal histoplasmosis associated strictures. We report the case of a 32-year-old man with a history of hyperimmunoglobulin M syndrome who presented with small bowel obstruction secondary to disseminated gastrointestinal histoplasmosis...
January 16, 2018: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/29340471/epididymo-orchitis-caused-by-histoplasma-capsulatumin-a-colombian-patient
#9
Carlos Andrés Botero-García, Álvaro Adolfo Faccini-Martínez, Erika Uribe, Omar-Javier Calixto, Carlos Eduardo Pérez-Díaz, Pedro Pablo Osejo-Diago, Pedro Gabriel Franco-Maz
Although histoplasmosis is generally a self-limited disease, disseminated infection can occur in patients lacking effective cell-mediated immunity, reaching virtually every organ, even the genitourinary tract in rare cases. We report a case of epididymo-orchitis in an immunocompetent 38-year-old bricklayer from the rural area of Villeta, Cundinamarca, Colombia. The patient presented with testicular pain and macroscopic scrotal changes requiring a left orchiectomy, with microbiological isolation and molecular confirmation of Histoplasma capsulatum...
November 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29325597/disseminated-histoplasmosis-in-an-immunocompetent-patient-utility-of-skin-scrape-cytology-in-diagnosis-a-case-report
#10
Tummidi Santosh, Kanchan Kothari, Shruti S Singhal, Vyoma V Shah, Roshni Patil
BACKGROUND: Histoplasma capsulatum is a dimorphic fungus predominately found in soils enriched with bird and bat excreta. Although several cases of histoplasmosis have been reported in India, diagnosis using cytology has been done in very few cases. CASE PRESENTATION: We report here a case of disseminated histoplasmosis in a 46-year-old Indian man. CONCLUSION: Skin scrape cytology is a simple, safe, and rapid technique to establish the initial diagnosis, thus promoting early treatment and favorable outcome, in cutaneous fungal infections...
January 12, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29319442/clinical-signs-treatment-and-prognostic-factors-for-dogs-with-histoplasmosis
#11
Allison G Wilson, Kate S KuKanich, Andrew S Hanzlicek, Mark E Payton
OBJECTIVE To determine the clinical manifestations of histoplasmosis in a large sample of dogs, compare outcomes achieved with fluconazole versus itraconazole, and identify variables available at the time of diagnosis with prognostic value. DESIGN Retrospective case series with nested cohort study. ANIMALS 79 dogs with confirmed histoplasmosis evaluated at 2 veterinary teaching hospitals from 1999 through 2015. PROCEDURES Medical records were reviewed and data extracted regarding clinical signs at evaluation, physical examination findings, clinical laboratory values, other diagnostic test results, treatments, and outcomes...
January 15, 2018: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/29276711/acute-kidney-injury-immune-thrombocytopenic-purpura-and-the-infection-that-binds-them-together-disseminated-histoplasmosis
#12
Pooja Sethi, Jennifer Treece, Chidinma Onweni, Vandana Pai, Sowminya Arikapudi, Lakshmi Kallur, Varun Kohli, Jonathan Moorman
Untreated human immunodeficiency virus (HIV) can be complicated by opportunistic infections, including disseminated histoplasmosis (DH). Although endemic to portions of the United States and usually benign, DH can rarely act as an opportunistic infection in immunocompromised patients presenting with uncommon complications such as acute kidney injury and idiopathic thrombocytopenic purpura. We report a rare presentation of DH presenting with acute kidney injury and immune thrombocytopenic purpura in an immunocompromised patient with HIV...
October 2017: Journal of Investigative Medicine High Impact Case Reports
https://www.readbyqxmd.com/read/29250310/histoplasmosis-hepatitis-after-orthotopic-liver-transplantation
#13
Laura Washburn, N Thao Galván, Sadhna Dhingra, Abbas Rana, John A Goss
Histoplasmosis is an endemic mycosis in the Ohio and Mississippi River valleys and can cause disseminated infection in immunocompromised hosts. Disseminated histoplasmosis is often respiratory in nature and most cases in transplant patients occur within 2 years post-transplantation. A 32-year-old male on mycophenolate and tacrolimus who underwent an orthotopic liver transplantation 10 years prior presented with generalized body aches, fevers, mild congestion, dysuria and elevated transaminases. Liver biopsy revealed epithelioid granulomas with narrow-based budding yeast, suggesting histoplasma...
December 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29225834/thrombocytopenia-and-disseminated-histoplasmosis-in-immunocompetent-adults
#14
Issa Kutkut, Laura Vater, Mitchell Goldman, Magdalena Czader, Jessica Swenberg, Zachary Fulkerson, Rakesh Mehta
Disseminated histoplasmosis among immunocompetent patients is rare, but may be associated with clinically significant refractory thrombocytopenia. Platelet counts often return to normal levels following antifungal therapy. Therefore, the most important management of this refractory thrombocytopenia is the recognition and treatment of histoplasmosis infection.
December 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/29197841/haemorrhagic-conversion-of-infectious-myelitis-in-an-immunocompromised-patient
#15
Michael Stephen Pohlen, Jonathan Sunwei Lin, Kevin Yuqi Wang, Mohammad Ghasemi-Rad, Christie M Lincoln
A 28-year-old man recently diagnosed with HIV (CD4 19 cells/mm3, viral load 3.6 million copies/mL, not on highly active antiretroviral therapy on initial diagnosis at outside hospital), disseminated histoplasmosis, shingles and syphilis presented with paraplegia developing over 3 days. Spine MRI demonstrated a longitudinally extensive cord lesion extending from C3 to the tip of the conus. Brain MRI was consistent with meningoencephalitis. Cerebrospinal fluid findings were notable for positive varicella zoster virus (VZV) and cytomegalovirus (CMV) PCRs as well as a Venereal Disease Research Laboratory titre of 1:2...
December 2, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29184348/subdural-empyema-in-disseminated-histoplasmosis
#16
Mansoor C Abdulla, Ram Narayan, Neena Mampilly, Prem Kumar
No abstract text is available yet for this article.
October 2017: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/29165514/-disseminated-histoplasmosis-and-hiv-infection-case-series-in-a-peruvian-hospital
#17
Giancarlo Pérez-Lazo, Julio Maquera-Afaray, Christian R Mejia, Raúl Castillo
BACKGROUND: Histoplasmosis is an endemic fungal infection in Peru and HIV coinfection leads to difficult diagnoses and high associated mortality. AIM: To describe clinical, epidemiological and clinical outcomes in patients with HIV infection with diagnosis of disseminated histoplasmosis (DH) at Guillermo Almenara Irigoyen National Hospital, Lima, Peru. METHODS: Retrospective, descriptive study; information was obtained from the computer registry of patients with HIV infection diagnosed with DH, during the period 1996-2014...
August 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/29164168/aids-related-endemic-mycoses-in-western-cape-south-africa-and-clinical-mimics-a-cross-sectional-study-of-adults-with-advanced-hiv-and-recent-onset-widespread-skin-lesions
#18
Ilan S Schwartz, Chris Kenyon, Rannakoe Lehloenya, Saskya Claasens, Zandile Spengane, Hans Prozesky, Rosie Burton, Arifa Parker, Sean Wasserman, Graeme Meintjes, Marc Mendelson, Jantjie Taljaard, Johann W Schneider, Natalie Beylis, Bonnie Maloba, Nelesh P Govender, Robert Colebunders, Sipho Dlamini
Background: Skin lesions are common in advanced HIV infection and are sometimes caused by serious diseases like systemic mycoses (SM). AIDS-related SM endemic to Western Cape, South Africa, include emergomycosis (formerly disseminated emmonsiosis), histoplasmosis, and sporotrichosis. We previously reported that 95% of patients with AIDS-related emergomycosis had skin lesions, although these were frequently overlooked or misdiagnosed clinically. Prospective studies are needed to characterize skin lesions of SM in South Africa and to help distinguish these from common HIV-related dermatoses...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29122900/a-30-year-delayed-presentation-of-disseminated-histoplasmosis-in-a-heart-transplant-recipient-diagnostic-challenges-in-a-non-endemic-area
#19
Aneela Majeed, Vikas Kapoor, Azka Latif, Tirdad Zangeneh
A 70-year-old man with history of heart transplant performed in 1986, presented with altered mental status. CT scan of brain showed ring-enhancing lesions, raising suspicion for metastatic malignancy. Work-up revealed bilateral adrenal masses, biopsy showed granulomatous changes consistent with histoplasmosis. The possibility of histoplasmosis was less likely as the patient had no prior history of symptomatic disease and had lived in the endemic area 30 years prior to presentation. Brain biopsy confirmed central nervous system involvement...
November 8, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29081364/usefulness-of-thick-blood-smears-in-the-diagnosis-of-disseminated-histoplasmosis
#20
José Y Rodríguez, Gerson J Rodríguez, Maria J Mendoza, Carlos A Álvarez-Moreno
No abstract text is available yet for this article.
December 2017: International Journal of Infectious Diseases: IJID
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