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Disseminated histoplasmosis

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https://www.readbyqxmd.com/read/29030061/disseminated-histoplasmosis-an-unusual-presentation-of-a-classic-midwest-infection
#1
Amrit K Kamboj, Saumya Shah, Subir Bhatia, Carl Andersen, Cyril Varghese
No abstract text is available yet for this article.
October 10, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/29024456/disseminated-histoplasmosis-in-an-immuno-competent-young-male-role-of-bone-marrow-examination-in-rapid-diagnosis
#2
Muhammad Shariq Shaikh, Ayesha Majeed Memon
Fungal infections are usually seen in elderly or immuno-compromised individuals particularly with human immunodeficiency virus infection. In immuno-competent individuals, they seldom present with overt clinical symptoms. In such cases diagnosis is made by combination of tests along with direct microscopic visualization of the organism. We present a case of immuno-competent individual who presented with unexplained fever and found to have Histoplasma capsulatum infection on bone marrow examination.
October 11, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29016342/case-report-histoplasmosis-in-himachal-pradesh-india-an-emerging-endemic-focus
#3
Vikram K Mahajan, Rashmi Kaul Raina, Suman Singh, Rattan Sagar Rashpa, Anuradha Sood, Pushpinder S Chauhan, Karaninder S Mehta, Ritu Rawat, Vikas Sharma
We describe four cases of histoplasmosis indigenous to Himachal Pradesh (India) that will be of considerable public health interest. A 48-year-old human immunodeficiency virus (HIV)-negative man with cervical and mediastinal lymphadenopathy, hepatosplenomegaly, adrenal mass, and bone marrow involvement was treated as disseminated tuberculosis without benefit. Progressive disseminated histoplasmosis was diagnosed from the fungus in smears from adrenal mass. Another 37-year-old HIV-positive man was on treatment of suspected pulmonary tuberculosis...
September 25, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28978596/safe-usage-of-anakinra-and-dexamethasone-to-treat-refractory-hemophagocytic-lymphohistiocytosis-secondary-to-acute-disseminated-histoplasmosis-in-a-patient-with-hiv-aids
#4
Anthony J Ocon, Birju D Bhatt, Cynthia Miller, Ruben A Peredo
Hemophagocytic lymphohistiocytosis (HLH) is a serious life-threatening disease if not recognised early. In patients with HIV/AIDS, this association has been reported following acute opportunistic infections, including histoplasmosis. However, optimal treatment is not known. We describe a male aged 46 years with AIDS who developed HLH following acute disseminated histoplasmosis. Presenting symptoms included fever, hepatosplenomegaly and pancytopenia. Bone marrow biopsy confirmed HLH. Initially, he was refractory to the treatment with amphotericin B, antiretroviral therapy and intravenous immunoglobulin (IVIG)...
October 4, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28956543/disseminated-histoplasmosis-in-aids-patients-an-urban-disease-experience-in-a-metropolis-in-the-middle-east-of-brasil
#5
Bianca da Silva Ferreira, Joâo Alves de Araújo Filho, Nayara Matos Pereira, Lucas de Miranda Godoy, Bruna Borges Lamounier, Elizon Dias Nunes, Lucas Espíndola Rosa
Histoplasmosis is a fungal disease commonly observed as an opportunistic disease in AIDS patients. It is a neglected disease in many countries, particularly Latin America, including Brazil. It is related with environmental factors, even in urban areas, where the incidence has increased. Implementing a descriptive ecological study, we performed a retrospective chart review for data collected between January 2003 and July 2014 for AIDS patients with histoplasmosis who lived in Goiania. The selected cases were georeferenced to analyse the incidence of histoplasmosis in AIDS patients in the metropolitan area of Goiania...
September 1, 2017: Le Infezioni in Medicina
https://www.readbyqxmd.com/read/28954600/disseminated-histoplasmosis-case-report-and-review-of-the-literature
#6
Séverine Evrard, Philippe Caprasse, Pierre Gavage, Myriam Vasbien, Jean Radermacher, Marie-Pierre Hayette, Rosalie Sacheli, Marjan Van Esbroeck, Lieselotte Cnops, Eric Firre, Laurent Médart, Filip Moerman, Jean-Marc Minon
Case report We report the case of a young Cameroonian woman who presented with cough, hyperthermia, weight loss, pancytopenia, and hepatosplenomegaly. A positive HIV serology was discovered and a chest radiography revealed a 'miliary pattern'. Bone marrow aspiration pointed out yeast inclusions within macrophages. Given the morphological aspect, the clinical presentation and immunosuppression, histoplasmosis was retained as a working hypothesis. Antiretroviral and amphotericin B treatments were promptly initiated...
September 28, 2017: Acta Clinica Belgica
https://www.readbyqxmd.com/read/28822097/a-38-year-old-woman-with-necrotising-cervical-lymphadenitis-due-to-histoplasma-capsulatum
#7
Esther van de Vosse, Annelies van Wengen, Wendy F van der Meide, Leo G Visser, Jaap T van Dissel
CASE PRESENTATION: We analysed a 38-year-old woman with disseminated histoplasmosis for primary immunodeficiency. Her blood showed no IFN-γ response while her peripheral blood mononuclear cells (PBMCs) did. We identified IFN-γ autoantibodies of the IgG class in her serum. CONCLUSION: IFN-γ autoantibodies leading to infections were so far mainly detected in people from Asian descent, where it was found to be associated with certain HLA types. This may be the first patient of African descent, and without the typical HLA types that predispose to this problem, that produces IFN-γ autoantibodies...
August 18, 2017: Infection
https://www.readbyqxmd.com/read/28805270/histoplasmosis-in-transplant-recipients
#8
REVIEW
Kiran Gajurel, Reshika Dhakal, Stan Deresinski
Histoplasma capsulatum is a dimorphic fungus that most often causes asymptomatic infection in the immunocompetent population. In immunocompromised patients, including solid organ transplant (SOT) and hematopoietic cell transplant (HCT) recipients, however, it is likely to cause severe life-threatening infection. Post-transplant histoplasmosis (PTH) in SOT is uncommon with an incidence of ≤1% and is even rarer in HCT patients. The majority of PTH in SOT is diagnosed in the first 2 years following transplantation...
August 14, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28804654/histoplasmosis-by-histoplasma-capsulatum-var-duboisii-observed-at-the-laboratory-of-pathological-anatomy-of-lom%C3%A3-in-togo
#9
Tchin Darré, Bayaki Saka, Abas Mouhari-Touré, Améyo Monique Dorkenoo, Koffi Amégbor, Vincent Palokinam Pitche, Gado Napo-Koura
Our study aimed to describe the epidemiological, clinical, and diagnostic aspects of African histoplasmosis in Togo through a descriptive and cross-sectional study on histological diagnosed African histoplasmosis in Pathology Department of Lomé from 2002 to 2016 (15 years). A total of 17 cases of African histoplasmosis were diagnosed. The sex ratio (M/F) was 1.8. The annual incidence was 1.1 cases. The mean age of the patients was 27.2 ± 0.4 years. All our patients were of social categories with a low socioeconomic level...
2017: Journal of Pathogens
https://www.readbyqxmd.com/read/28797485/clinical-perspectives-in-the-diagnosis-and-management-of-histoplasmosis
#10
REVIEW
Marwan M Azar, Chadi A Hage
With increasing numbers of travelers and immunocompromised patients, histoplasmosis, caused by the dimorphic fungus Histoplasma capsulatum, has become a disease of national extent. The clinical spectrum of histoplasmosis is very wide, in terms of disease cadence, onset, distribution, and severity. A multipronged approach is recommended for diagnosis. Manifestations that are always treated include moderate to severe acute pulmonary histoplasmosis, disseminated disease, and histoplasmosis in immunocompromised individuals...
September 2017: Clinics in Chest Medicine
https://www.readbyqxmd.com/read/28736209/histoplasmosis-presenting-as-laryngeal-ulcer-in-a-post-renal-transplant-male-an-unusual-case-from-india
#11
P M Jawale, H V Gulwani
Histoplasmosis has variable clinical presentation that mimics various benign and malignant lesions. It is more often associated with pulmonary lesions and disseminated form of disease. Herein, we report a rare case of localized laryngeal histoplasmosis in a 62-year-old Indian man who presented with hoarseness of voice and dysphagia. Post-renal transplant, he was on immunosuppressive drugs for last three years. Laryngoscopy revealed an ulceroproliferative growth at base of tongue, which was extending upto the pyriform fossa...
July 20, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/28717672/coccidioidomycosis-a-cause-of-sarcoidosis
#12
Tim Kuberski, Isaac Yourison
BACKGROUND: Sarcoidosis is a granulomatous disease of unknown etiology and coccidioidomycosis is a granulomatous fungal infection endemic to the southwestern United States. Clinical observations on patients with sarcoidosis and coccidioidomycosis simultaneously led to the hypothesis that sarcoidosis can be caused by the fungus Coccidioides. METHODS: Two patients with sarcoidosis and coccidioidomycosis were studied, one prospectively (ie, a patient with sarcoidosis was predicted to develop coccidioidomycosis) and the other retrospectively (ie, a patient with coccidioidomycosis develops sarcoidosis)...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28710196/disseminated-histoplasmosis-presenting-as-multiple-oral-ulcers
#13
Nicholas Hendren, Christina Yek, Jason Mull, James B Cutrell
A 61-year-old female with a history of advanced HIV disease and chronic hepatitis B was presented with an 8-week history of painful oral ulcers. She appeared systemically well but examination revealed multiple well-demarcated clean-based ulcers on the tongue and hard palate. Biopsy of one of the lesions showed numerous histiocytes containing intracellular yeast forms consistent with Histoplasma capsulatum var. capsulatum Fungal blood cultures subsequently grew H. capsulatum var. capsulatum, confirming a diagnosis of disseminated histoplasmosis...
July 14, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28702025/cellular-and-molecular-defects-underlying-invasive-fungal-infections-revelations-from-endemic-mycoses
#14
REVIEW
Pamela P Lee, Yu-Lung Lau
The global burden of fungal diseases has been increasing, as a result of the expanding number of susceptible individuals including people living with human immunodeficiency virus (HIV), hematopoietic stem cell or organ transplant recipients, patients with malignancies or immunological conditions receiving immunosuppressive treatment, premature neonates, and the elderly. Opportunistic fungal pathogens such as Aspergillus, Candida, Cryptococcus, Rhizopus, and Pneumocystis jiroveci are distributed worldwide and constitute the majority of invasive fungal infections (IFIs)...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28701830/role-of-fine-needle-aspiration-cytology-in-diagnosis-of-disseminated-histoplasmosis-in-an-immunocompetent-patient-a-case-report
#15
Sagarika Samantaray, Sasmita Panda, Sashibhusan Dash, Niranjan Rout
Histoplasmosis is a mycotic infection caused by dimorphic fungus, Histoplasma capsulatum. The organisms are usually found within the cells (macrophages). This organism mostly affects lungs in immunocompetent individuals and disseminated forms are seen in immunocompromised cases. Here, we describe a case of disseminated histoplasmosis in an immunocompetent, 35-year-old female with lymphadenopathy diagnosed by fine-needle aspiration cytology and cell block.
July 2017: Journal of Cytology
https://www.readbyqxmd.com/read/28687695/hiding-in-plain-sight-a-case-of-chronic-disseminated-histoplasmosis-with-central-nervous-system-involvement
#16
Guramrinder Singh Thind, Sandeep Patri
A 64-year-old man presented with gradual onset of confusion, ataxia and 25-pound weight loss over 3 months. MRI of the brain revealed two enhancing cerebellar lesions suspicious for metastases. Positron emission tomography-CT showed enhancement of cervical and axillary lymph nodes. Left axillary lymph node biopsy showed no evidence of malignancy but instead showed fungal organisms morphologically consistent with Histoplasma spp. Disseminated histoplasmosis with central nervous system involvement was suspected...
July 6, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28677260/correlation-of-cd4-counts-with-clinical-and-histopathological-findings-in-disseminated-histoplasmosis-a-10-year-retrospective-study
#17
Sondang P Sirait, Kusmarinah Bramono, Nathalia Hermanto
BACKGROUND: Disseminated cutaneous histoplasmosis (DCH) is one of the manifestations of systemic histoplasmosis infection in HIV-positive patients. Interaction between host immune status and histoplasmosis infection is still poorly understood. It is thought that immune status, represented by CD4 counts, may be correlated with clinical and histopathological findings. OBJECTIVE: To correlate the CD4 counts with the different clinical and histopathological findings in cutaneous histoplasmosis...
July 5, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28652964/a-necrotic-tonsillar-lesion-an-unusual-presentation-of-disseminated-histoplasmosis
#18
Christopher Keen, Hwajeong Lee, Lisa Galati, John Fantauzzi, Richard Blinkhorn, Timothy A Jennings, Sudha Chaturvedi, Marc A Judson
We report a case of tonsillar histoplasmosis with hematogenous dissemination in a woman receiving infliximab for Crohn's disease. She also had a history of sarcoidosis. Due to the unusual location and confounding medical history, our case provided a diagnostic dilemma. Histoplasma infection was confirmed histologically, and the patient responded well to appropriate treatment.
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28647712/disseminated-histoplasmosis-in-a-patient-with-hiv-diagnosed-by-simple-bedside-investigations
#19
Pongsakorn Buraphat, Wannarat Pongpirul, Patama Suttha
No abstract text is available yet for this article.
June 24, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28626627/tonsillar-ulceration-as-manifestation-of-disseminated-african-histoplasmosis-in-an-immunocompetent-portuguese-host
#20
L Cardoso, C Silva, N Marques, C Veríssimo
Histoplasmosis is a systemic mycosis caused by Histoplasma capsulatum. Rare in Europe but endemic in some regions of Brazil, United States, Africa and Asia. Most of the cases are asymptomatic. Disseminated form is defined by the presence of an extra-pulmonary focus, particularly associated with immunosuppression. We report a case of an unilateral persisted tonsillar ulceration, in an immunocompetent Portuguese host, as manifestation of disseminated African histoplasmosis 45 years later after living 3 years in Africa...
September 2017: Medical Mycology Case Reports
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