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Disseminated histoplasmosis

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https://www.readbyqxmd.com/read/28822097/a-38-year-old-woman-with-necrotising-cervical-lymphadenitis-due-to-histoplasma-capsulatum
#1
Esther van de Vosse, Annelies van Wengen, Wendy F van der Meide, Leo G Visser, Jaap T van Dissel
CASE PRESENTATION: We analysed a 38-year-old woman with disseminated histoplasmosis for primary immunodeficiency. Her blood showed no IFN-γ response while her peripheral blood mononuclear cells (PBMCs) did. We identified IFN-γ autoantibodies of the IgG class in her serum. CONCLUSION: IFN-γ autoantibodies leading to infections were so far mainly detected in people from Asian descent, where it was found to be associated with certain HLA types. This may be the first patient of African descent, and without the typical HLA types that predispose to this problem, that produces IFN-γ autoantibodies...
August 18, 2017: Infection
https://www.readbyqxmd.com/read/28805270/histoplasmosis-in-transplant-recipients
#2
REVIEW
Kiran Gajurel, Reshika Dhakal, Stan Deresinski
Histoplasma capsulatum is a dimorphic fungus that most often causes asymptomatic infection in the immunocompetent population. In immunocompromised patients, including solid organ transplant (SOT) and hematopoietic cell transplant (HCT) recipients, however, it is likely to cause severe life-threatening infection. Post-transplant histoplasmosis (PTH) in SOT is uncommon with an incidence of ≤ 1% and is even rarer in HCT patients. The majority of PTH in SOT is diagnosed in the first 2 years following transplantation...
August 14, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28804654/histoplasmosis-by-histoplasma-capsulatum-var-duboisii-observed-at-the-laboratory-of-pathological-anatomy-of-lom%C3%A3-in-togo
#3
Tchin Darré, Bayaki Saka, Abas Mouhari-Touré, Améyo Monique Dorkenoo, Koffi Amégbor, Vincent Palokinam Pitche, Gado Napo-Koura
Our study aimed to describe the epidemiological, clinical, and diagnostic aspects of African histoplasmosis in Togo through a descriptive and cross-sectional study on histological diagnosed African histoplasmosis in Pathology Department of Lomé from 2002 to 2016 (15 years). A total of 17 cases of African histoplasmosis were diagnosed. The sex ratio (M/F) was 1.8. The annual incidence was 1.1 cases. The mean age of the patients was 27.2 ± 0.4 years. All our patients were of social categories with a low socioeconomic level...
2017: Journal of Pathogens
https://www.readbyqxmd.com/read/28797485/clinical-perspectives-in-the-diagnosis-and-management-of-histoplasmosis
#4
REVIEW
Marwan M Azar, Chadi A Hage
With increasing numbers of travelers and immunocompromised patients, histoplasmosis, caused by the dimorphic fungus Histoplasma capsulatum, has become a disease of national extent. The clinical spectrum of histoplasmosis is very wide, in terms of disease cadence, onset, distribution, and severity. A multipronged approach is recommended for diagnosis. Manifestations that are always treated include moderate to severe acute pulmonary histoplasmosis, disseminated disease, and histoplasmosis in immunocompromised individuals...
September 2017: Clinics in Chest Medicine
https://www.readbyqxmd.com/read/28736209/histoplasmosis-presenting-as-laryngeal-ulcer-in-a-post-renal-transplant-male-an-unusual-case-from-india
#5
P M Jawale, H V Gulwani
Histoplasmosis has variable clinical presentation that mimics various benign and malignant lesions. It is more often associated with pulmonary lesions and disseminated form of disease. Herein, we report a rare case of localized laryngeal histoplasmosis in a 62-year-old Indian man who presented with hoarseness of voice and dysphagia. Post-renal transplant, he was on immunosuppressive drugs for last three years. Laryngoscopy revealed an ulceroproliferative growth at base of tongue, which was extending upto the pyriform fossa...
July 20, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/28717672/coccidioidomycosis-a-cause-of-sarcoidosis
#6
Tim Kuberski, Isaac Yourison
BACKGROUND: Sarcoidosis is a granulomatous disease of unknown etiology and coccidioidomycosis is a granulomatous fungal infection endemic to the southwestern United States. Clinical observations on patients with sarcoidosis and coccidioidomycosis simultaneously led to the hypothesis that sarcoidosis can be caused by the fungus Coccidioides. METHODS: Two patients with sarcoidosis and coccidioidomycosis were studied, one prospectively (ie, a patient with sarcoidosis was predicted to develop coccidioidomycosis) and the other retrospectively (ie, a patient with coccidioidomycosis develops sarcoidosis)...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28710196/disseminated-histoplasmosis-presenting-as-multiple-oral-ulcers
#7
Nicholas Hendren, Christina Yek, Jason Mull, James B Cutrell
A 61-year-old female with a history of advanced HIV disease and chronic hepatitis B was presented with an 8-week history of painful oral ulcers. She appeared systemically well but examination revealed multiple well-demarcated clean-based ulcers on the tongue and hard palate. Biopsy of one of the lesions showed numerous histiocytes containing intracellular yeast forms consistent with Histoplasma capsulatum var. capsulatum Fungal blood cultures subsequently grew H. capsulatum var. capsulatum, confirming a diagnosis of disseminated histoplasmosis...
July 14, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28702025/cellular-and-molecular-defects-underlying-invasive-fungal-infections-revelations-from-endemic-mycoses
#8
REVIEW
Pamela P Lee, Yu-Lung Lau
The global burden of fungal diseases has been increasing, as a result of the expanding number of susceptible individuals including people living with human immunodeficiency virus (HIV), hematopoietic stem cell or organ transplant recipients, patients with malignancies or immunological conditions receiving immunosuppressive treatment, premature neonates, and the elderly. Opportunistic fungal pathogens such as Aspergillus, Candida, Cryptococcus, Rhizopus, and Pneumocystis jiroveci are distributed worldwide and constitute the majority of invasive fungal infections (IFIs)...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28701830/role-of-fine-needle-aspiration-cytology-in-diagnosis-of-disseminated-histoplasmosis-in-an-immunocompetent-patient-a-case-report
#9
Sagarika Samantaray, Sasmita Panda, Sashibhusan Dash, Niranjan Rout
Histoplasmosis is a mycotic infection caused by dimorphic fungus, Histoplasma capsulatum. The organisms are usually found within the cells (macrophages). This organism mostly affects lungs in immunocompetent individuals and disseminated forms are seen in immunocompromised cases. Here, we describe a case of disseminated histoplasmosis in an immunocompetent, 35-year-old female with lymphadenopathy diagnosed by fine-needle aspiration cytology and cell block.
July 2017: Journal of Cytology
https://www.readbyqxmd.com/read/28687695/hiding-in-plain-sight-a-case-of-chronic-disseminated-histoplasmosis-with-central-nervous-system-involvement
#10
Guramrinder Singh Thind, Sandeep Patri
A 64-year-old man presented with gradual onset of confusion, ataxia and 25-pound weight loss over 3 months. MRI of the brain revealed two enhancing cerebellar lesions suspicious for metastases. Positron emission tomography-CT showed enhancement of cervical and axillary lymph nodes. Left axillary lymph node biopsy showed no evidence of malignancy but instead showed fungal organisms morphologically consistent with Histoplasma spp. Disseminated histoplasmosis with central nervous system involvement was suspected...
July 6, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28677260/correlation-of-cd4-counts-with-clinical-and-histopathological-findings-in-disseminated-histoplasmosis-a-10-year-retrospective-study
#11
Sondang P Sirait, Kusmarinah Bramono, Nathalia Hermanto
BACKGROUND: Disseminated cutaneous histoplasmosis (DCH) is one of the manifestations of systemic histoplasmosis infection in HIV-positive patients. Interaction between host immune status and histoplasmosis infection is still poorly understood. It is thought that immune status, represented by CD4 counts, may be correlated with clinical and histopathological findings. OBJECTIVE: To correlate the CD4 counts with the different clinical and histopathological findings in cutaneous histoplasmosis...
July 5, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28652964/a-necrotic-tonsillar-lesion-an-unusual-presentation-of-disseminated-histoplasmosis
#12
Christopher Keen, Hwajeong Lee, Lisa Galati, John Fantauzzi, Richard Blinkhorn, Timothy A Jennings, Sudha Chaturvedi, Marc A Judson
We report a case of tonsillar histoplasmosis with hematogenous dissemination in a woman receiving infliximab for Crohn's disease. She also had a history of sarcoidosis. Due to the unusual location and confounding medical history, our case provided a diagnostic dilemma. Histoplasma infection was confirmed histologically, and the patient responded well to appropriate treatment.
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28647712/disseminated-histoplasmosis-in-a-patient-with-hiv-diagnosed-by-simple-bedside-investigations
#13
Pongsakorn Buraphat, Wannarat Pongpirul, Patama Suttha
No abstract text is available yet for this article.
June 24, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28626627/tonsillar-ulceration-as-manifestation-of-disseminated-african-histoplasmosis-in-an-immunocompetent-portuguese-host
#14
L Cardoso, C Silva, N Marques, C Veríssimo
Histoplasmosis is a systemic mycosis caused by Histoplasma capsulatum. Rare in Europe but endemic in some regions of Brazil, United States, Africa and Asia. Most of the cases are asymptomatic. Disseminated form is defined by the presence of an extra-pulmonary focus, particularly associated with immunosuppression. We report a case of an unilateral persisted tonsillar ulceration, in an immunocompetent Portuguese host, as manifestation of disseminated African histoplasmosis 45 years later after living 3 years in Africa...
September 2017: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/28617878/granulomatous-hepatitis-a-rare-primary-manifestation-of-disseminated-histoplasmosis-in-a-renal-transplant-recipient
#15
Jiten P Kothadia, Vyshnavi Kone, Shah Giashuddin
No abstract text is available yet for this article.
June 2017: Journal of Gastrointestinal and Liver Diseases: JGLD
https://www.readbyqxmd.com/read/28554708/protothecosis-in-a-patient-with-t-cell-lymphocytic-leukemia
#16
Mariana S Fernández, Florencia D Rojas, María E Cattana, Javier E Mussin, María de Los Ángeles Sosa, Carlos D Benzoni, Gustavo E Giusiano
Human protothecosis is a rare infection caused by algae of the genus Prototheca. Prototheca wickerhamii has been recognized as the main species that causes infection in immunocompromised hosts with deficits in innate or cellular immunity. We report a case of persisting subcutaneous protothecosis in a patient with T-cell large granular lymphocyte leukemia, who also presented a history of disseminated histoplasmosis.
May 27, 2017: Revista Argentina de Microbiología
https://www.readbyqxmd.com/read/28548709/-polka-dot-macrophages-on-cytology-of-bilateral-adrenal-masses-nailing-disseminated-histoplasmosis
#17
Sumit Grover, Pavneet Kaur Selhi, Neena Sood, Ridhi Sood, Harpreet Kaur
Histoplasma capsulatum is a saprophytic fungus that in immunocompetent individuals causes self-limited pulmonary infection; however, in immunosuppressed patients involvement of the reticuloendothelial system, alimentary tract, urinary tract, and central nervous system is fairly common. Rarely patients present with bilateral adrenal masses which mimic tuberculosis and metastasis on radiology because of associated central necrosis. Ultrasound guided FNAC aided by special stains like Periodic Acid Schiff (PAS) and Gomori Methenamine Silver (GMS) may help in early diagnosis in such dubious cases...
May 26, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28530163/gastrointestinal-histoplasmosis-a-case-series
#18
Rashi Sharma, Lipika Lipi, Smeeta Gajendra, Ishani Mohapatra, Ruchika K Goel, Rajan Duggal, Smruti Ranjan Mishra, Dheeraj Gautam
Histoplasmosis is an invasive mycosis caused by inhalation of the spores of dimorphic fungi Histoplasma capsulatum. The disease manifests in the lung as acute or chronic pulmonary histoplasmosis and in severe cases gets disseminated in multiple organs like skin, adrenal gland, central nervous system, lymph node, liver, spleen, bone marrow, and gastrointestinal tract. It occurs most commonly in immunodeficient patients like HIV-positive patients and transplant recipients, while immunocompetent hosts are affected rarely...
May 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28528522/reconstitution-inflammatory-syndrome-like-reactive-hemophagocytic-syndrome-associated-with-disseminated-histoplasmosis-in-a-hiv-patient
#19
REVIEW
Sandra M Gómez-Espejo, Julián Olalla-Sierra, Pilar Marí-Jiménez, Teresa Pereda-Salguero, Javier Pérez-Stachowski, Javier de-la-Torre-Lima, Alfonso Del-Arco-Jiménez, José L Prada-Pardal
We describe an unusual clinical association of disseminated histoplasmosis with reactive hemophagocytic syndrome. We report the case of a new HIV-positive patient with reconstitution inflammatory syndrome like reactive hemophagocytic syndrome associated with disseminated histoplasmosis. We describe the clinical case, the procedures performed, the treatment provided and the patient's evolution. A figure of liver biopsy Grocott's silver methenamine stain that shows lots of uniform ovoid yeasts in portal spaces' macrophages that supports the diagnosis of disseminated histoplasmosis in our case...
August 2017: Mycopathologia
https://www.readbyqxmd.com/read/28476105/case-of-disseminated-histoplasmosis-in-a-hiv-infected-patient-revealed-by-nasal-involvement-with-maxillary-osteolysis
#20
A C Lehur, M Zielinski, J Pluvy, V Grégoire, S Diamantis, A Bleibtreu, C Rioux, A Picard, D Vallois
BACKGROUND: Disseminated Histoplasmosis (DH) is a rare manifestation of Acquired Immune Deficiency Syndrome (AIDS) in European countries. Naso-maxillar osteolysis due to Histoplasma capsulatum var. capsulatum (Hcc) is unusual in endemic countries and has never been reported in European countries. Differential diagnoses such as malignant tumors, cocaine use, granulomatosis, vasculitis and infections are more frequently observed and could delay and/or bias the final diagnosis. CASE PRESENTATION: We report the case of an immunocompromised patient infected by Human Immunodeficiency Virus (HIV) with naso-maxillar histoplasmosis in a non-endemic country...
May 5, 2017: BMC Infectious Diseases
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