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Disseminated histoplasmosis

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https://www.readbyqxmd.com/read/27904204/a-rare-case-of-juvenile-systemic-lupus-erythematosus-with-disseminated-histoplasmosis
#1
Piyabi Sarkar, Keya Basu, Mamata Guha Mallick Sinha
Histoplasmosis is a systemic fungal infection caused by dimorphic fungus, Histoplasma capsulatum. Immunocompetent individuals usually have self-limiting or localized disease whereas immunocompromised individuals develop disseminated disease. The occurrence of progressive disseminated histoplasmosis in juvenile systemic lupus erythematosus is extremely rare with only one reported case in literature showing such association. Therefore, we report a case of severe opportunistic fungal infection caused by Histoplasma in a 13-year-old girl who was diagnosed with juvenile lupus erythematosus, subsequently developed septic shock and died of the disease despite of aggressive antifungal therapy...
November 2016: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/27875685/progressive-disseminated-histoplasmosis-a-systematic-review-on-the-performance-of-non-culture-based-diagnostic-tests
#2
Diego R Falci, Elias R Hoffmann, Diego D Paskulin, Alessandro C Pasqualotto
The diagnosis of progressive disseminated histoplasmosis is often a challenge to clinicians, especially due to the low sensitivity and long turnaround time of the classic diagnostic methods. In recent years, studies involving a variety of non-culture-based diagnostic tests have been published in the literature. The aim of this paper is to perform a systematic review by selecting articles evaluating non-culture-based diagnostic methods in the diagnosis of progressive disseminated histoplasmosis. We searched for articles evaluating detection of antibody, antigens, and DNA methods...
November 19, 2016: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27817934/unusual-presentation-of-disseminated-histoplasmosis
#3
Dalvir Gill, Ryan Dean, Jaswinder Virk, Mitch Lyons, Matthew Hess
No abstract text is available yet for this article.
November 2, 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27812393/primary-histoplasma-capsulatum-enterocolitis-mimicking-peptic-and-inflammatory-bowel-disease
#4
Rahman Nakshabendi, Andrew C Berry, Daisy Torres-Miranda, Francis Daniel LaBarbera, Ozdemir Kanar, Ahmad Nakshabandi, Imad Nakshabendi
In immunocompromised patients, histoplasmosis may present as disseminated disease. We present a 52-year-old Caucasian male with symptoms of dyspepsia, postprandial epigastric pain, nausea, and nonbloody diarrhea. Upper and lower gastrointestinal endoscopies were suspicious for inflammatory bowel disease (IBD); however, biopsies were consistent with histoplasmosis, specifically in the duodenum.
2016: Case Reports in Gastrointestinal Medicine
https://www.readbyqxmd.com/read/27759351/progressive-disseminated-histoplasmosis-with-coomb-s-positive-hemolytic-anemia-in-an-immunocompetent-host
#5
Radhey Shyam Chejara, C L Nawal, M K Agrawal, Pradeep Mittal, Abhishek Agrawal, Sujata Agarwal
Progressive Disseminated Histoplasmosis (PDH) is mainly described in immuno-compromised individuals and rare in immuno-competent subjects. Here we report a case of progressive disseminated histoplasmosis with Comb's positive hemolytic anemia, which is infrequently reported from a country like India where histoplasmosis is not an endemic mycosis.
July 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27756991/cytodiagnosis-of-disseminated-histoplasmosis-in-an-immunocompetent-individual-with-molluscum-contagiosum-like-skin-lesions-and-lymphadenopathy
#6
Prajwala Gupta, Minakshi Bhardwaj
Disseminated histoplasmosis is caused by the dimorphic fungus Histoplasma capsulatum (H. capsulatum). The early clinical manifestations are nonspecific, often lead to diagnostic difficulty, and is misdiagnosed as tuberculosis and seen usually in immunosuppressed states. Fine needle aspiration cytology (FNAC) is a simple, safe, and quick technique to establish the initial diagnosis of H. capsulatum, thereby prompting early treatment. The skin involvement is rare in disseminated disease and we describe a case of disseminated histoplasmosis in an immunocompetent patient with unusual molluscum contagiosum like umbilicated skin lesions and FNAC of the cervical lymph node was the only tool for rapid and early confirmatory diagnosis...
July 2016: Journal of Cytology
https://www.readbyqxmd.com/read/27752372/typical-facial-lesions-a-window-of-suspicion-for-progressive-disseminated-histoplasmosis-a-case-of-asian-prototype
#7
Prasan K Panda, Siddharth Jain, Rita Sood, Rajni Yadav, Naval K Vikram
Histoplasmosis is caused by a dimorphic fungus Histoplasma capsulatum in endemic areas, mainly America, Africa, and Asia. In India, it is being reported from most states; however, it is endemic along the Ganges belt. We report a case of an apparently immunocompetent male who presented with 3-month history of fever, cough, and weight loss with recent onset odynophagia and had hepatosplenomegaly and mucocutaneous lesions over the face. The differential diagnosis of leishmaniasis, tuberculosis, leprosy, fungal infection, lymphoproliferative malignancy, and other granulomatous disorders was considered, but he succumbed to his illness...
2016: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/27744308/ast-to-alt-ratio-is-elevated-in-disseminated-histoplasmosis-as-compared-to-localized-pulmonary-disease-and-other-endemic-mycoses
#8
Andrej Spec, Christopher R Barrios, Usama Ahmad, Laurie A Proia
Severe pulmonary or disseminated histoplasmosis often necessitates presumptive antifungal treatment while awaiting definitive diagnosis. Histoplasma antigen assays have improved sensitivity but results may lag up to 7 days. In order to increase diagnostic certainty, "soft clues" may be looked for in laboratory and radiologic data, such as elevated alkaline phosphatase or ferritin levels and findings of mediastinal adenopathy or hepatosplenomegaly. To determine if elevated aspartate aminotransferase (AST) to alanine aminotransferase (ALT) ratio is specific to histoplasmosis or a non-specific marker for disseminated fungal infection or sepsis in general, we retrospectively examined records of all patients diagnosed with an endemic fungal infection (EFI) at Rush University Medical Center from January of 1997 to October of 2012, and a cohort of septic patients with elevated liver enzymes...
October 14, 2016: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/27728393/interesting-case-of-disseminated-histoplasmosis
#9
Abhishek Sharma, C L Nawal, M K Agarwal, Pradeep Mital, R S Chejara
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27688988/chronic-pulmonary-histoplasmosis-and-its-clinical-significance-an-under-reported-systemic-fungal-disease
#10
Venkataramana Kandi, Ritu Vaish, Padmavali Palange, Mohan Rao Bhoomagiri
Histoplasmosis is a systemic fungal mycosis caused by Histoplasma capsulatum. It is a dimorphic fungus which lives as a saprophyte in the environment and occasionally infects immunosuppressed people. H capsulatum is a ubiquitous fungus present throughout the globe and is more common in the temperate world. Human infection with H capsulatum occurs through respiratory route by inhalation of spores present in the air as droplet nuclei. Pulmonary histoplasmosis is difficult to diagnose, more so in the regions where tuberculosis is endemic, and many infected patients remain asymptomatic...
August 26, 2016: Curēus
https://www.readbyqxmd.com/read/27688460/experience-of-varied-presentation-of-chronic-progressive-disseminated-histoplasmosis-in-immunocompetent-patients-a-diagnostic-conundrum
#11
Roumi Ghosh, Pranshu Mishra, Sumit Sen, Prasanta Kumar Maiti, Govinda Chatterjee
We report two cases of chronic progressive disseminated histoplasmosis with unusual and rare clinical picture in a patient with no underlying risk factor. One 50-year-old male, presented with hoarseness of voice, chronic cough, with a history of nonresponding anti-tubercular therapy, revealed mucocutaneous lesions on examination. Fungating vocal cord lesions were visualized on bronchoscopy, raised suspicion of carcinoma. The second case, a 22-year-old female, referred to hospital with suspected vasculitis, with complaints of "off and on" fever with decreased oral intake, arthralgia, who later developed generalized nodular skin eruptions...
September 2016: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/27625302/prevalence-and-lethality-among-patients-with-histoplasmosis-and-aids-in-the-midwest-region-of-brazil
#12
Thaísa C Silva, Carolina M Treméa, Ana Laura S A Zara, Ana Flávia Mendonça, Cássia S M Godoy, Carolina R Costa, Lúcia K H Souza, Maria R R Silva
Histoplasmosis is a systemic mycosis that is considered an important public health problem. In this work, we performed a descriptive, observational, cross-sectional and retrospective study with a secondary data analysis of medical records from 2000 to 2012 at a tertiary hospital. The study sample consisted of 275 patients with laboratory-confirmed Disseminated Histoplasmosis (DH)/AIDS. The results showed that the prevalence of DH associated with AIDS was 4.4%. The majority of patients were young adult men with fever in 84...
September 14, 2016: Mycoses
https://www.readbyqxmd.com/read/27535733/laryngeal-histoplasmosis
#13
Hina A Ansari, Noora Saeed, Nazoora Khan, Naba Hasan
Histoplasmosis is a fungal infection, having interesting synonyms such as Cave disease, Darling's disease, Ohio Valley disease, reticuloendotheliosis, Spelunker's lung and Caver's disease. The aetiological agent is a dimorphic fungus, Histoplasma capsulatum, causing chronic granulomatous disease. The route of transmission is by inhalation of dust particles from soil contaminated by excrement of birds or bats, harbouring the small spores or microconidia, which is considered the infectious form of fungus. The spectrum of illness ranges from subclinical infection of the lung to progressive disseminated disease...
2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27527560/utility-of-antigen-testing-for-the-diagnosis-of-ocular-histoplasmosis-in-four-cats-a-case-series-and-literature-review
#14
Kathryn M Smith, Ann R Strom, Margi A Gilmour, Elise LaDouceur, Christopher M Reilly, Barbara A Byrne, Verena K Affolter, Jane E Sykes, David J Maggs
CASE SERIES SUMMARY: This case series describes the clinical utility of antigen testing for the diagnosis of feline ocular histoplasmosis. Four cats with suspected (n = 2) or confirmed (n = 2) ocular histoplasmosis are described: three from Oklahoma and one from California. In one case, serial urine antigen tests, as well as a serum antigen test for Histoplasma capsulatum, were negative; however, light microscopy identified microorganisms consistent with H capsulatum in ocular tissues at necropsy...
August 15, 2016: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/27516534/cutaneous-histoplasmosis-with-prominent-parasitization-of-epidermal-keratinocytes-report-of-a-case
#15
Hedieh H Honarpisheh, Jonathan L Curry, Kristen Richards, Priyadharsini Nagarajan, Phyu P Aung, Carlos A Torres-Cabala, Doina Ivan, Carol R Drucker, Richard Cartun, Victor G Prieto, Michael T Tetzlaff
Disseminated histoplasmosis most commonly occurs in immunosuppressed individuals and involves the skin in approximately 6% of patients. Cutaneous histoplasmosis with an intraepithelial-predominant distribution has not been described. A 47-year-old man was admitted to our institution with fever and vancomycin-resistant enterococcal bacteremia. He had been diagnosed with T-cell prolymphocytic leukemia 4 years earlier and had undergone matched-unrelated-donor stem cell transplant 2 years earlier; on admission, he had relapsed disease...
December 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27450641/-clinical-problems-in-medical-mycology-problem-number-50
#16
Laura Guadalupe Walker, Alicia Arechavala, Fernando Messina, Ricardo Negroni, Gabriela Santiso
We present the case of a 34 year-old man, HIV-positive, who had suffered a disseminated histoplasmosis treated with amphotericin B one year before his admission. He was admitted at the Infectious Diseases Muñiz Hospital with a non-lithiasic chlolecystitis. During the clinical examination perigenital skin lesions compatible with tinea cruris, as well as proximal subungual onychomycoses of toenails, were observed. Microsporum gypseum was isolated from both types of lesions. Oral terbinafine led to a good clinical response...
July 19, 2016: Revista Iberoamericana de Micología
https://www.readbyqxmd.com/read/27443422/disseminated-histoplasmosis-and-aids-a-prospective-and-multicentre-study-to-evaluate-the-performance-of-different-diagnostic-tests
#17
E R Hoffmann, T C Daboit, D D Paskulin, A A Monteiro, D R Falci, T Linhares, J M Flores, L Z Goldani, M G de Melo, P R Behar, A C Pasqualotto
The burden of histoplasmosis has been poorly documented in most of the endemic areas for the disease, including Brazil. Also, modern non-culture-based diagnostic tests are often non-available in these regions. This was a prospective cohort study in HIV-infected patients with suspected disseminated disease evaluated with different diagnostic tests. Patients were enrolled in three referral medical centres in Porto Alegre, Brazil. Among 78 evaluated patients, disseminated histoplasmosis was confirmed in eight individuals (10...
July 22, 2016: Mycoses
https://www.readbyqxmd.com/read/27365926/disseminated-histoplasmosis-a-fatal-opportunistic-infection-in-disguise
#18
Ruchita Tyagi, Arshdeep Kaur, Pavneet Kaur Selhi, Harpreet Kaur Puri, Neena Sood
Histoplasma capsulatum is no longer confined to certain geographic areas and should always be considered in the differential diagnosis of lymphadenopathy and organomegaly in HIV-positive patients. We present an unusual case of a 20-year-old immunocompromised male of African origin presenting with fever, jaundice, hepatosplenomegaly, and retroperitoneal and cervical lymphadenopathy. Fine needle aspiration (FNA) smears from the cervical lymph node revealed numerous yeast forms of histoplasma in macrophages. The patient succumbed to the fulminant infection...
July 2016: Journal of Laboratory Physicians
https://www.readbyqxmd.com/read/27329388/histoplasma-capsulatum-infection-with-extensive-lytic-bone-lesions-mimicking-lch
#19
Divya Mariam Mathews, Rikki John, Valsan Verghese, Harshad Parmar, Narendra Chaudhary, Sataroopa Mishra, Leni Mathew
Multiple lytic bone lesions in a child can be a manifestation of various diseases like Langerhans cell histiocytosis, metastatic neuroblastoma, leukemia, hyperparathyroidism, multifocal osteomyelitis and histoplasmosis. Disseminated histoplasmosis caused by Histoplasma capsulatum var. duboisii is well known to present with multiple osteolytic lesions in immunocompromised adults and is mostly restricted to the African subcontinent. Histoplasmosis seen in American and Asian countries is caused by Histoplasma capsulatum var...
June 20, 2016: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/27298506/amphotericin-b-liposome-induced-acrocyanosis-and-elevated-serum-creatinine
#20
Xiangcai Zhang, Jie Jin, Chuang Cai, Ren Zheng, Yu Wang, Yingying Xu
A 77-year-old male patient developed acrocyanosis and pain after treatment with amphotericin B liposome 150 mg daily intravenously for disseminated histoplasmosis, and subsequently developed elevated serum creatinine. Amphotericin B liposome was discontinued, and anisodamine was used intravenously to treat acrocyanosis and pain induced by amphotericin B liposome for 9 days and patient was cured. Naranjo adverse drug reaction probability scale score was 5, the World Health Organization-Uppsala Monitoring Centre criteria: Probable, indicating a probable adverse reaction to amphotericin B liposome...
May 2016: Indian Journal of Pharmacology
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