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Disseminated histoplasmosis

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https://www.readbyqxmd.com/read/29862155/progressive-disseminated-histoplasmosis-in-an-immunocompetent-adult-a-case-report
#1
Nitesh Kumar Bauddha, Ranveer Singh Jadon, Saikat Mondal, N K Vikram, Rita Sood
Histoplasmosis is a systemic fungal infection caused by Histoplasma capsulatum which occurs endemically in some parts of the world like North and Central America particularly in Mississippi and Ohio River valleys, but is uncommon in India. Progressive disseminated form of histoplasmosis (PDH) usually occurs in the immune-compromised hosts especially in HIV positive population. In PDH any organ can be involved like lung, liver, spleen, brain, adrenals etc . Involvement of oral cavity and buccal mucosa in PDH is common but pharyngeal involvement is rare...
May 2018: Intractable & Rare Diseases Research
https://www.readbyqxmd.com/read/29789991/asymptomatic-histoplasma-pylephlebitis-in-an-orthotopic-liver-transplant-recipient-a-case-report-and-literature-review
#2
REVIEW
Pakpoom Phoompoung, Methee Chayakulkeeree, Popchai Ngamskulrungroj, Ananya Pongpaibul
Histoplasma capsulatum is one of the most common pathogenic dimorphic fungi in Thailand. Its usual clinical syndrome is progressive disseminated histoplasmosis, whereas isolated hepatic histoplasmosis is extremely rare. Here, we report the world's first reported case of hepatic histoplasmosis with pylephlebitis in a 45-year-old Thai male who underwent orthotopic liver transplantation due to hepatitis B cirrhosis. Histopathology of the recipient's liver showed infiltration of fungal organisms in portal vein and hepatic granulomas...
May 22, 2018: Mycopathologia
https://www.readbyqxmd.com/read/29768547/clinical-outcomes-and-risk-factors-for-death-from-disseminated-histoplasmosis-in-patients-with-aids-who-visited-a-high-complexity-hospital-in-campo-grande-ms-brazil
#3
Barbara Cristina Scarcelli Boigues, Anamaria Mello Miranda Paniago, Gláucia Moreira Espíndola Lima, Maina de Oliveira Nunes, Silvia Naomi de Oliveira Uehara
INTRODUCTION: Disseminated histoplasmosis (DH) is a systemic mycosis caused by Histoplasma capsulatum (H. capsulatum) and is characterized by progressive and fatal evolution in immunocompromised patients. Moreover, it is considered an AIDS-defining disease. METHODS: We performed an observational, analytical, retrospective study to identify the clinical outcomes and risk factors for death from DH in patients with AIDS at an infectious diseases service facility in Brazil between September 2011 and July 2016...
March 2018: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29742119/prior-subclinical-histoplasmosis-revealed-in-nigeria-using-histoplasmin-skin-testing
#4
Rita O Oladele, Conchita Toriello, Folasade T Ogunsola, Olusola O Ayanlowo, Philip Foden, Adetona S Fayemiwo, Iriagbonse I Osaigbovo, Anthony A Iwuafor, Shuwaram Shettima, Halimat A Ekundayo, Malcolm D Richardson, David W Denning
OBJECTIVES: Disseminated histoplasmosis is an AIDS-defining illness. Histoplasmosis is commonly misdiagnosed as tuberculosis. Nigeria has the second highest number of people living with HIV/AIDS in Africa. The present study was carried out to investigate the prevalence of skin sensitivity amongst Nigerians to histoplasmin. DESIGN: A cross-sectional study was conducted in six centres across five geopolitical zones of Nigeria. METHODS: We recruited both healthy non-HIV and HIV-positive adults with CD4 count ≥ 350 cells/mm3 regardless of their ART status from March to May 2017...
2018: PloS One
https://www.readbyqxmd.com/read/29738315/diagnosis-and-treatment-of-histoplasmosis-in-solid-organ-transplant-patients
#5
Kiran Gajurel, Reshika Dhakal, Stan Deresinski
PURPOSE OF REVIEW: Unlike immunocompetent hosts, solid organ transplant (SOT) recipients with posttransplant histoplasmosis (PTH) often present with disseminated disease and have an attributable mortality of approximately 10%. In this review, we discuss currently available diagnostic tests and treatment strategies in PTH. RECENT FINDINGS: None of the available tests have a 100% diagnostic accuracy. Histoplasma antigen assays are the most sensitive commercially available tests...
May 5, 2018: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/29730356/not-your-typical-arizona-granuloma-a-case-report-of-disseminated-histoplasmosis-%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2
#6
Sara Sani, Jawad Bilal, Elly Varma, Shubha Kollampare, Dominick Sudano
No abstract text is available yet for this article.
May 3, 2018: American Journal of Medicine
https://www.readbyqxmd.com/read/29695056/burden-of-serious-fungal-infections-in-argentina
#7
Fernando O Riera, Juan P Caeiro, David W Denning
The number of fungal infections at any given time in Argentina is not known. Here we estimate the burden of serious fungal infections in Argentina for the first time. Specific population statistics were searched from multiple sources, local literature was identified, and estimates made. Some additional data were sourced from the Ministry of Health, the Global Initiative for Asthma (GINA) program, and national haematology and transplant societies. Argentina has a population of 43.8 million, with 25% of this total being children under 15 years...
April 24, 2018: Journal of Fungi (Basel, Switzerland)
https://www.readbyqxmd.com/read/29666076/histoplasma-meets-crohn-s-disease-a-rare-case-of-new-onset-ascites
#8
Charles Robert Bosshardt, John Gnann, Nilesh Lodhia
A 53-year-old man with Crohn's disease treated with adalimumab was hospitalised with abdominal pain, fatigue, fever and chills. CT scan of the abdomen showed chronic thickening of the terminal ileum and cecum and new-onset ascites. Further studies revealed weakly positive urine and serum histoplasma antigen. Laparoscopy revealed metastatic caking of the omentum and abdominal wall; peritoneal biopsy demonstrated organisms morphologically consistent with Histoplasma capsulatum No dissemination outside of the peritoneal cavity was evident...
April 17, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29657917/hemophagocytic-lymphohistiocytosis-hlh-secondary-to-disseminated-histoplasmosis-in-the-setting-of-acquired-immunodeficiency-syndrome-aids
#9
Samuel Asanad, Brendan Cerk, Veronica Ramirez
Hemophagocytic lymphohistiocytosis (HLH) is a rare and aggressive disease involving immune system over-activation leading to hemophagocytosis. HLH requires early diagnosis and prompt treatment initiation, especially in patients with Acquired Immunodeficiency Syndrome (AIDS). We present a case of a middle-aged male with AIDS and renal failure, who developed HLH secondary to disseminated histoplasmosis. Etoposide chemotherapy as recommended by the HLH 2004 Guidelines was deferred and treatment focused instead on anti-fungal therapy...
June 2018: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/29643654/role-of-endoscopic-ultrasound-guided-fine-needle-aspiration-in-adrenal-lesions-analysis-of-32-patients
#10
Rakesh K Gupta, Kaushik Majumdar, Ravindra K Saran, Siddharth Srivastava, Puja Sakhuja, Vineeta V Batra
Objective: Endoscopic ultrasound-guided fine-needle aspiration cytology (EUS-FNAC) is a precise and safe technique that provides both radiological and pathological diagnosis with a better diagnostic yield and minimal adverse events. EUS-FNAC led to the remarkable increase in the detection rate of incidentaloma found during radiologic staging or follow-up in various malignancy or unrelated conditions. Aims: We did this preliminary study with an aim to evaluate the role of EUS-FNA in diagnosing and classifying adrenal lesions, clinical impact, and compare the outcome with the previously published literature...
April 2018: Journal of Cytology
https://www.readbyqxmd.com/read/29623159/diagnosing-ring-enhancing-lesions-in-the-brain-of-a-patient-with-aids-without-brain-biopsy-a-case-of-central-nervous-system-histoplasmoma
#11
Rachel Beekman, Jessica M Hu, Steven I Aronin, Maricar F Malinis
We report a case of a Puerto Rican male with advanced AIDS who presented with multiple falls and pancytopenia. Magnetic resonance imaging (MRI) of the brain, as initial workup, revealed 2 ring-enhancing brain lesions. Initial cerebrospinal fluid analysis revealed minimal cells, mildly elevated protein, and no organism seen on gram stain. Due to prohibitive thrombocytopenia, brain biopsy was deferred. He had neither clinical nor radiographic improvement despite empiric therapy for both toxoplasmosis and bacterial abscesses...
April 2018: Neurohospitalist
https://www.readbyqxmd.com/read/29610172/histoplasmosis-myocarditis-in-an-immunocompetent-host-after-a-recreational-mud-run
#12
Briana L Scott, Jennifer I Sherwin, Kyle J Rehder, Michael J Campbell, Caroline P Ozment
Mud runs are an increasingly popular recreational fitness activity across the United States, combining a running race through an obstacle course with submersion in mud. Recent reports estimate 4 million people have participated in these types of events over the last 5 years. We describe an atypical case of myocarditis and multiorgan failure from disseminated histoplasmosis in a previously healthy pediatric patient, likely acquired during participation in a mud run. Although cases of histoplasmosis-associated endocarditis and pericarditis have been reported in the literature, cases of histoplasmosis myocarditis are rare...
April 2018: Pediatrics
https://www.readbyqxmd.com/read/29601494/the-burden-of-serious-fungal-infections-in-cameroon
#13
Christine E Mandengue, David W Denning
Fungal infections are frequent in Cameroon, and invasive fungal infections are sometimes detected, usually in HIV-infected patients. For these reasons, we have estimated the burden of fungal infections. Using published literature and population estimates for the at-risk group, we used deterministic modelling to derive national incidence and prevalence estimates for the most serious fungal diseases. HIV infection is common and an estimated 120,000 have CD4 counts <200 × 10⁶/mL and commonly present with opportunistic infection...
March 30, 2018: Journal of Fungi (Basel, Switzerland)
https://www.readbyqxmd.com/read/29595679/central-nervous-system-histoplasmosis-multicenter-retrospective-study-on-clinical-features-diagnostic-approach-and-outcome-of-treatment
#14
MULTICENTER STUDY
Joseph Wheat, Thein Myint, Ying Guo, Phebe Kemmer, Chadi Hage, Colin Terry, Marwan M Azar, James Riddell, Peter Ender, Sharon Chen, Kareem Shehab, Kerry Cleveland, Eden Esguerra, James Johnson, Patty Wright, Vanja Douglas, Pascalis Vergidis, Winnie Ooi, John Baddley, David Bamberger, Raed Khairy, Holenarasipur R Vikram, Elizabeth Jenny-Avital, Geetha Sivasubramanian, Karen Bowlware, Barbara Pahud, Juan Sarria, Townson Tsai, Maha Assi, Satish Mocherla, Vidhya Prakash, David Allen, Catherine Passaretti, Shirish Huprikar, Albert Anderson
Central nervous system (CNS) involvement occurs in 5 to 10% of individuals with disseminated histoplasmosis. Most experience has been derived from small single center case series, or case report literature reviews. Therefore, a larger study of central nervous system (CNS) histoplasmosis is needed in order to guide the approach to diagnosis, and treatment.A convenience sample of 77 patients with histoplasmosis infection of the CNS was evaluated. Data was collected that focused on recognition of infection, diagnostic techniques, and outcomes of treatment...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29592837/a-proposal-of-antifungal-epidemiological-cut-off-values-against-histoplasma-capsulatum-var-capsulatum-based-on-the-susceptibility-of-isolates-from-hiv-infected-patients-with-disseminated-histoplasmosis-in-northeastern-brazil
#15
Raimunda Sâmia Nogueira Brilhante, Glaucia Morgana de Melo Guedes, Maria Lucilene Queiroz da Silva, Débora Souza Collares Maia Castelo-Branco, Rossana de Aguiar Cordeiro, José Júlio Costa Sidrim, Marcos Fábio Gadelha Rocha
Epidemiological cutoff values (ECV) have been used as a tool to detect the acquisition of resistance mechanisms to antifungal drugs. In this context, the objective of this study was to determine the epidemiological cutoff values for classic antifungals against Histoplasma capsulatum var. capsulatum isolates from HIV-infected patients with the diagnosis of disseminated histoplasmosis. Initially, the minimum inhibitory concentrations (MIC) for amphotericin B, itraconazole, fluconazole, voriconazole and caspofungin against 138 isolates of H...
March 25, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29588907/disseminated-toxoplasmosis-in-a-patient-with-advanced-acquired-immunodeficiency-syndrome
#16
Ricardo Garcia Pastorello, Anderson da Costa Lino Costa, Marcio Valente Yamada Sawamura, Antonio Carlos Nicodemo, Amaro Nunes Duarte-Neto
Extracerebral toxoplasmosis, with pulmonary involvement and shock, is a rare form of toxoplasmosis in patients with advanced AIDS. It can mimic pneumocystosis, histoplasmosis, and disseminated tuberculosis, and should be considered in the differential diagnosis of causes of respiratory failure and fulminant disease in this group of individuals, especially in areas where the Toxoplasma gondii infection is highly prevalent and in those without proper use of antimicrobial prophylaxis. We report the case of a 46-year-old male patient who presented to the emergency department with uremia, requiring urgent dialysis...
January 2018: Autopsy & case reports
https://www.readbyqxmd.com/read/29563205/multicenter-validation-of-commercial-antigenuria-reagents-to-diagnose-progressive-disseminated-histoplasmosis-in-people-living-with-hiv-aids-in-two-latin-american-countries
#17
Diego H Cáceres, Blanca E Samayoa, Narda G Medina, Angela M Tobón, Brenda J Guzmán, Danicela Mercado, Angela Restrepo, Tom Chiller, Eduardo E Arathoon, Beatriz L Gómez
Histoplasmosis is an important cause of mortality in patients with AIDS, especially in countries with limited access to antiretroviral therapies and diagnostic tests. However, many disseminated infections in Latin America go undiagnosed. A simple, rapid method to detect Histoplasma capsulatum infection in regions where histoplasmosis is endemic would dramatically decrease the time to diagnosis and treatment, reducing morbidity and mortality. The aim of this study was to validate a commercial monoclonal Histoplasma galactomannan (HGM) enzyme-linked immunosorbent assay (Immuno-Mycologics [IMMY], Norman, OK, USA) in two cohorts of people living with HIV/AIDS (PLHIV)...
June 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29535767/gastrointestinal-histoplasmosis-presenting-as-an-acute-abdomen-with-jejunal-perforation
#18
Bryan R Anderson, Jaron Marriott, Chinthaka Bulathsinghala, Humayun Anjum, Salim Surani
Introduction: Gastrointestinal histoplasmosis (GH) is a well-described albeit uncommon disease. It is found almost exclusively in the immunocompromised host, especially those with untreated HIV and low CD4 counts. Presentation with intestinal perforation is seen mostly commonly in the colon. We present a patient with jejunal perforation, and there have been only 3 previous cases reported in the literature. Case: A 39-year-old male with known, untreated HIV presented to the ED with an acute abdomen after experiencing worsening intermittent abdominal pain for 2 months before that was associated with nausea, vomiting, diarrhea, and weight loss...
2018: Case Reports in Medicine
https://www.readbyqxmd.com/read/29532302/a-case-of-disseminated-histoplasmosis-in-a-patient-with-rheumatoid-arthritis-on-abatacept
#19
Nina Jain, Jeffrey B Doyon, Jacob E Lazarus, Inga-Marie Schaefer, Melanie E Johncilla, Agoston T Agoston, Anuj K Dalal, Gustavo E Velásquez
Biologic agents are effective treatments for rheumatoid arthritis but are associated with important risks, including severe infections. Tumor Necrosis Factor (TNF) α inhibitors are known to increase the risk of systemic fungal infections such as disseminated histoplasmosis. Abatacept is a biologic agent with a mechanism different from that of TNFα inhibitors: It suppresses cellular immunity by competing for the costimulatory signal on antigen-presenting cells. The risk of disseminated histoplasmosis for patients on abatacept is not known...
May 2018: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29530850/posaconazole-induced-pseudohyperaldosteronism
#20
Kevin Kuriakose, Whitney J Nesbitt, Matthew Greene, Bryan Harris
A woman in her late 60s with disseminated histoplasmosis was treated with posaconazole because first-line therapies were not tolerated. She subsequently presented with decompensated heart failure, hypertension, and hypokalemia. Laboratory tests revealed low renin and aldosterone levels. A potential mechanism is inhibition of the enzyme 11β-hydroxysteroid dehydrogenase 2, with resultant apparent mineralocorticoid excess.
May 2018: Antimicrobial Agents and Chemotherapy
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