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https://www.readbyqxmd.com/read/29913098/radiofrequency-radiation-emitted-from-wi-fi-2-4-ghz-causes-impaired-insulin-secretion-and-increased-oxidative-stress-in-rat-pancreatic-islets
#1
Ali Masoumi, Narges Karbalaei, S M J Mortazavi, Mohammad Shabani
PURPOSE: There is a great concern regarding the possible adverse effects of electromagnetic radiation (EMR). This study investigated the effects of EMR induced by Wi-Fi (2.45GHz) on insulin secretion and antioxidant redox systems in the rat pancreas. MATERIALS AND METHODS: Adult male Sprague-Dawley rats in the weight range of 230 to 260 g were divided into control, sham, Wi-Fi exposed groups. After long term exposure (4 h/day for 45 days) to Wi-Fi electromagnetic radiation, plasma levels of glucose and insulin during intraperitoneal glucose tolerance test were measured...
June 18, 2018: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/29912856/melatonin-attenuates-endoplasmic-reticulum-stress-in-acute-pancreatitis
#2
Qian Zhao, Xinyue Tang, Junhua Huang, Jiajia Li, Qinfen Chen, Yangjie Sun, Jiansheng Wu
OBJECTIVES: The objective of this study is to explore the effect of melatonin on endoplasmic reticulum stress in acute pancreatitis (AP) and the molecular mechanism. METHODS: Acute pancreatitis was induced in vivo in Sprague-Dawley rats by the retrograde injection of 5% taurocholate into the biliopancreatic duct and in vitro by treating AR42J cells with cerulein (10 nmol/L) plus lipopolysaccharide (LPS) (10 mg/L). The rats and cells were treated with melatonin (50 mg/kg in rats and 0...
June 16, 2018: Pancreas
https://www.readbyqxmd.com/read/29912852/emodin-attenuates-autophagy-response-to-protect-the-pancreas-from-acute-pancreatitis-failure
#3
Xiaozheng Yu, Chunyun Li, Hechao Song, Xueyan Wang, Yinan Guo, Lijian Cui, Xiaoya Liu, Cheng Chi, Ruixia Liu, Chenghong Yin
OBJECTIVES: The aim of this study was to investigate the effects of emodin on attenuating autophagy response in acute pancreatitis (AP) models. METHODS: Acute pancreatitis was induced in Wistar rats by injecting 3% sodium taurocholate into the biliopancreatic duct. Emodin (40 mg/kg per day) was then given intragastrically, administrated 2 hours after AP induction. Rats were killed 24 hours after AP induction. The pancreatic injury was assessed using biochemical and histological approaches...
June 16, 2018: Pancreas
https://www.readbyqxmd.com/read/29912201/application-of-end-to-end-anastomosis-in-robotic-central-pancreatectomy
#4
Rong Liu, Zi-Zheng Wang, Yuan-Xing Gao, Yong Xu
Central pancreatectomy is carried out for the treatment of benign or low-malignant potential tumors located in the pancreatic neck or proximal part of pancreatic body. With technological development, the robotic surgical system has shown its advantage in minimally invasive surgery and been increasingly applied in central pancreatectomy. However, reconstruction of the continuity of pancreas with end-to-end anastomosis after robotic central pancreatectomy has not been applied. In this study, we report surgical techniques for robotic central pancreatectomy with end-to-end anastomosis...
June 2, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29912186/generation-of-scaffold-free-three-dimensional-insulin-expressing-pancreatoids-from-mouse-pancreatic-progenitors-in-vitro
#5
Marissa A Scavuzzo, Jessica Teaw, Diane Yang, Malgorzata Borowiak
The pancreas is a complex organ composed of many different cell types that work together to regulate blood glucose homeostasis and digestion. These cell types include enzyme-secreting acinar cells, an arborized ductal system responsible for the transportation of enzymes to the gut, and hormone-producing endocrine cells. Endocrine beta-cells are the sole cell type in the body that produce insulin to lower blood glucose levels. Diabetes, a disease characterized by a loss or the dysfunction of beta-cells, is reaching epidemic proportions...
June 2, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29912000/neoplasms-of-the-neuroendocrine-pancreas-an-update-in-the-classification-definition-and-molecular-genetic-advances
#6
Julie M Guilmette, Vania Nosé
This review focuses on discussing the main modifications of the recently published 2017 WHO Classification of Neoplasms of the Neuroendocrine Pancreas (panNEN). Recent updates separate pancreatic neuroendocrine tumors into 2 broad categories: well-differentiated pancreatic neuroendocrine tumors (panNET) and poorly differentiated pancreatic neuroendocrine carcinoma (panNEC), and incorporates a new subcategory of "well-differentiated high-grade NET (G3)" to the well-differentiated NET category. This new classification algorithm aims to improve the prediction of clinical outcomes and survival and help clinicians select better therapeutic strategies for patient care and management...
June 14, 2018: Advances in Anatomic Pathology
https://www.readbyqxmd.com/read/29911459/a-case-of-linezolid-induced-toxicity
#7
Philip E Tobias, Christy A Varughese, Amy P Hanson, Payal K Gurnani
Adverse effects of linezolid are typically limited to diarrhea, nausea, and headache when shorter durations are used; however, as extended durations of linezolid therapy are increasingly more common, additional monitoring parameters should be considered in these patients. We describe a unique case of hypoglycemia, lactic acidosis, and pancreatitis related to an extended duration of linezolid therapy. A 52-year-old woman presented with altered mental status, abdominal pain, and hypotension following six weeks of linezolid and ertapenem therapy...
January 1, 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/29910119/secretagogin-protects-pdx1-from-proteasomal-degradation-to-control-a-transcriptional-program-required-for-%C3%AE-cell-specification
#8
Katarzyna Malenczyk, Edit Szodorai, Robert Schnell, Gert Lubec, Gábor Szabó, Tomas Hökfelt, Tibor Harkany
OBJECTIVE: Specification of endocrine cell lineages in the developing pancreas relies on extrinsic signals from non-pancreatic tissues, which initiate a cell-autonomous sequence of transcription factor activation and repression switches. The steps in this pathway share reliance on activity-dependent Ca2+ signals. However, the mechanisms by which phasic Ca2+ surges become converted into a dynamic, cell-state-specific and physiologically meaningful code made up by transcription factors constellations remain essentially unknown...
June 5, 2018: Molecular Metabolism
https://www.readbyqxmd.com/read/29909684/hydatid-cyst-of-the-pancreas-causing-both-acute-pancreatitis-and-splenic-vein-thrombosis
#9
O Ozsay, F Gungor, Serkan Karaisli, Ibrahim Kokulu, Osman Nuri Dilek
Hydatid cyst of the pancreas is a rarely seen entity even in endemic countries. Cyst may causes several symptoms due to external compression or fistulisation to pancreaticobiliary tract or small bowel. A 23-year-old female patient was referred with a complaint of abdominal pain. Preoperative imaging revealed an undefined cyst in the tail of pancreas. She underwent distal pancreatectomy and splenectomy, with a diagnosis of acute pancreatitis due to cystopancreatic duct fistula and also left-sided portal hypertension due to splenic vein thrombosis...
June 18, 2018: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/29909240/tissue-specific-expression-and-circulating-concentrations-of-nesfatin-1-in-domestic-animals
#10
K A Morton, L Hargreaves, S Mortazavi, L P Weber, A M Blanco, S Unniappan
Nesfatin-1 is a naturally occurring 82-amino acid protein encoded in the precursor nucleobindin-2 (NUCB2) and has been implicated in multiple physiological functions, including food intake and blood glucose regulation. This study aimed to characterize nesfatin-1 in domestic species, especially cats (Felis catus), dogs (Canis lupus familiaris), and pigs (Sus scrofa). Our in silico analysis demonstrated that the NUCB2/nesfatin-1 amino acid sequence, especially the bioactive core region of the peptide, is very highly conserved (more than 90% identity) in domestic animals...
May 9, 2018: Domestic Animal Endocrinology
https://www.readbyqxmd.com/read/29907490/multi-institutional-study-of-carbon-ion-radiotherapy-for-locally-advanced-pancreatic-cancer-japan-carbon-ion-radiation-oncology-study-group-j-cros-study-1403-pancreas
#11
Shohei Kawashiro, Shigeru Yamada, Masahiko Okamoto, Tatsuya Ohno, Takashi Nakano, Makoto Shinoto, Yoshiyuki Shioyama, Kenji Nemoto, Yuka Isozaki, Hiroshi Tsuji, Tadashi Kamada
PURPOSE: The aim of this multi-institutional study was to evaluate the efficacy and safety of carbon-ion radiotherapy (C-ion RT) for locally advanced pancreatic cancer (LAPC). METHODS AND MATERIALS: Patients with LAPC treated with C-ion RT from April 2012 to December 2014 at 3 institutions were retrospectively analyzed. Patients with pathologically-confirmed invasive ductal adenocarcinoma of the pancreas were eligible. The prescribed dose was 52.8 Gy (relative biological effectiveness weighted absorbed dose; RBE) or 55...
May 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29906691/intraductal-tubulopapillary-neoplasm-of-the-pancreas-presenting-as-recurrent-acute-pancreatitis-a-case-report
#12
Sodai Sakamoto, Yosuke Tsuruga, Yuki Fujii, Hiroki Shomura, Atsuo Hattori, Keizo Kazui
INTRODUCTION: The 2010 World Health Organization classification of intraductal neoplasms of the pancreas includes intraductal tubulopapillary neoplasms (ITPNs) and intraductal papillary mucinous neoplasms, the latter being a rare and new concept. ITPN sometimes cause acute pancreatitis; therefore, distinguishing ITPN from idiopathic acute pancreatitis is important but challenging. PRESENTATION OF CASE: We present the case of a 72-year-old male who had recurrent pancreatitis for the past 2 years, his diagnosis was idiopathic acute pancreatitis...
June 4, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29905828/mir-149-negative-regulation-of-mafa-is-involved-in-the-arsenite-induced-dysfunction-of-insulin-synthesis-and-secretion-in-pancreatic-beta-cells
#13
Qian Sun, Qianlei Yang, Hui Xu, Junchao Xue, Chao Chen, Xingfen Yang, Xiaohua Gao, Qizhan Liu
Chronic exposure to arsenic, a potent environmental oxidative stressor, is associated with the incidence of diabetes. However, the mechanisms for arsenite-induced reduction of insulin remain largely unclear. After CD1 mice were treated with 20 or 40 ppm arsenite in the drinking water for 12 months, the mice showed reduced fasting insulin levels, a depression in glucose clearance, and lower insulin content in the pancreas. The levels of glucose-stimulated insulin secretion (GSIS) in pancreatic β-cells isolated from arsenite-exposed mice were low compared to those for control mice...
June 14, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29904686/data-on-investigation-of-hypoglycemic-anti-cholesteremic-in-vivo-antioxidant-and-pancreatic-beta-cell-protective-effect-of-putranjiva-roxburghii-wall-bark-in-streptozotocin-induced-diabetic-rats
#14
Kedar Kalyani Abhimanyu, Chaudhari Sanjay Ravindra, Rao Srinivasa Avanapu
The data existing in this article are associated to the antidiabetic activity of ethyl acetate extract of Putranjiva roxburghii Wall barks (EAPR) in streptozotocin (STZ) induced diabetic rats at a dose of 250 & 500 mg/kg by oral route for 21 days. The phytochemical screening of the extract was carried out by gas chromatography and mass spectrometry. Diabetes was induced by streptozotocin (50 mg/kg; i.p), EAPR (250 & 500 mg/kg; b.wt) and standard Insulin (6 IU/animal; subcutaneous; o.i.d) were administered to the diabetic rats...
June 2018: Data in Brief
https://www.readbyqxmd.com/read/29904299/cholesterolosis-as-a-cause-of-acute-pancreatitis
#15
Ricardo E De Armas, Jacob M Rosenberg, Andrew Z Fenves
Acute pancreatitis is an inflammatory condition of the pancreas manifesting with abdominal pain and elevated serum levels of pancreatic enzymes. Gallstones and chronic alcohol use are the most commonly described causes. A less studied cause is cholesterolosis, gallbladder polyps that cause mechanical obstruction of the sphincter of Oddi. Here, we present the case of a 55-year-old woman who presented with acute pancreatitis and was found to have cholesterol polyps in her gallbladder with no evidence of gallstones...
July 2018: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/29903803/orthotopic-and-heterotopic-murine-models-of-pancreatic-cancer-and-their-different-responses-to-folfirinox-chemotherapy
#16
Derek J Erstad, Mozhdeh Sojoodi, Martin S Taylor, Sarani Ghoshal, Allen A Razavi, Katherine A Graham-O'Regan, Nabeel Bardeesy, Cristina R Ferrone, Michael Lanuti, Peter Caravan, Kenneth K Tanabe, Bryan C Fuchs
INTRODUCTION: Syngeneic, immunocompetent allograft tumor models recapitulate important aspects of the tumor microenvironment and have short tumor latency with predictable growth kinetics, making them useful for trialing novel therapeutics. We describe surgical techniques for orthotopic and heterotopic PDAC tumor implantation and characterize phenotypes based on implantation site. METHODS: Mice (n=8 per group) were implanted with 104 cells in the pancreas or flank...
June 14, 2018: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/29903633/incidence-and-reasons-of-pancreatic-resection-in-patients-with-asymptomatic-serous-cystadenoma
#17
Carlo Lombardo, Sara Iacopi, Francesca Menonna, Niccolò Napoli, Emanuele Kauffmann, Juri Bernardini, Andrea Cacciato Insilla, Piero Boraschi, Francescamaria Donati, Carla Cappelli, Daniela Campani, Davide Caramella, Ugo Boggi
BACKGROUND/OBJECTIVES: Despite diagnostic refinements, pancreatic resection (PR) is eventually performed in some patients with asymptomatic serous cystadenoma (A-SCA). The aim of this study was to define incidence and reasons of PR in A-SCA. METHODS: A retrospective analysis of a prospectively maintained database was performed for all the patients referred for pancreatic cystic lesions (PCL) between January 2005 and March 2016. RESULTS: Overall, there were 1488 patients with PCL, including 1271 (85...
June 8, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29903238/-effects-of-high-sucrose-high-fat-diet-feeding-time-on-establishment-of-a-mouse-model-of-gestational-diabetes-mellitus
#18
Jiacui Ren, Ye Ding, Lu Yin, Rui Qin, Yuanhong She, Jin Xu, Zhixu Wang
OBJECTIVE: The present study focuses on the effects of different highsucrose/high-fat diet feeding time on body weight, glucose and lipid metabolism parameters and pathological changes of pancreas and liver in pregnant mice. METHODS: Female C57 BL/6 J mice were divided into three groups randomly: normal control group( C) and two different high-sucrose/high-fat diet feeding time groups( H1 and H2). Body weight, food and energy intakes and blood glucose were measured at multiple time points before and during pregnancy...
January 2018: Wei Sheng Yan Jiu, Journal of Hygiene Research
https://www.readbyqxmd.com/read/29901857/the-effect-of-supplementing-sheep-with-rapeseed-and-linseed-oils-on-the-activity-of-pancreatic-digestive-enzymes
#19
Barbara Kowalik, Małgorzata P Majewska, Renata Miltko, Grzegorz Bełżecki
The aim of this study was to compare the effect of rapeseed and linseed oils added to the diet on pancreatic enzyme activities in sheep. The experiment was conducted on six adult sheep with a catheter introduced into the common bile-pancreatic duct and a T-cannula into the duodenum. The animals were divided into three groups, two sheep in each. A twice-replicated 3 × 3 Latin square was used in the experimental design. The sheep were fed meadow hay and the concentrate alone or the same ration supplemented with rapeseed or linseed oils at a dose of 5% of the basal diet...
June 14, 2018: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/29901726/pancreatic-radiation-effect-in-apoptosis-related-rectal-radiation-toxicity
#20
Sei Hwan You, Mee Yon Cho, Joon Hyung Sohn, Chang Geol Lee
Pancreatic radiation effect (PRE) can be a component of gastrointestinal tract (GIT) radiotoxicity. This inter-organ correlation between the GIT and the pancreas was assessed through a rat model. Separate local irradiation to the abdomen and the pelvis was applied concurrently for 8-week-old male Sprague Dawley rats. Abdominal irradiation was categorized into pancreatic shield (PS) and non-pancreatic shield (NPS) irradiation. After 5 Gy and 15 Gy irradiation, the rectal mucosa was analyzed at the first week (early phase, Ep) and the 14th week (late phase, Lp)...
June 12, 2018: Journal of Radiation Research
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