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https://www.readbyqxmd.com/read/27913456/acute-promyelocytic-leukemia-preventing-early-complications-and-late-toxicities
#1
Sameem Abedin, Jessica K Altman
Acute promyelocytic leukemia (APL) is a unique subtype of acute myeloid leukemia (AML), which presents with a distinct coagulopathy. Therapeutic advances have made APL one of the true success stories in oncology, transforming this once lethal disease into the most curable form of AML. For many patients, cure will now be achieved without the use of chemotherapy. It is hoped that limiting chemotherapy will reduce mortality even further, particularly among more vulnerable older adults whose survival lagged behind that of younger patients...
December 2, 2016: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/27913289/damage-repair-and-regeneration-in-insect-cuticle-the-story-so-far-and-possibilities-for-the-future
#2
REVIEW
Eoin Parle, Jan-Henning Dirks, David Taylor
The exoskeleton of an insect can contain countless specializations across an individual, across developmental stages, and across the class Insecta. Hence, the exoskeleton's building material cuticle must perform a vast variety of functions. Cuticle displays a wide range of material properties which are determined by several known factors: the amount and orientation of the chitin fibres, the constituents and degree of cross-linking and hydration of the protein matrix, the relative amounts of exo- and endocuticle, and the shape of the structures themselves...
November 29, 2016: Arthropod Structure & Development
https://www.readbyqxmd.com/read/27912049/autophagy-captures-the-nobel-prize
#3
Sharon A Tooze, Ivan Dikic
This year's Nobel Prize in Physiology or Medicine has been awarded to Yoshinori Ohsumi for the discovery of the molecular principles governing autophagy, an intracellular degradation pathway routed via lysosomes or vacuoles. It is a story of a simple yet insightful yeast genetic screen that revealed the inner circuitry of one of the most powerful quality-control pathways in cells.
December 1, 2016: Cell
https://www.readbyqxmd.com/read/27910735/birth-of-the-cool-a-two-centuries-decline-in-emotional-expression-in-anglophone-fiction
#4
Olivier Morin, Alberto Acerbi
The presence of emotional words and content in stories has been shown to enhance a story's memorability, and its cultural success. Yet, recent cultural trends run in the opposite direction. Using the Google Books corpus, coupled with two metadata-rich corpora of Anglophone fiction books, we show a decrease in emotionality in English-speaking literature starting plausibly in the nineteenth century. We show that this decrease cannot be explained by changes unrelated to emotionality (such as demographic dynamics concerning age or gender balance, changes in vocabulary richness, or changes in the prevalence of literary genres), and that, in our three corpora, the decrease is driven almost entirely by a decline in the proportion of positive emotion-related words, while the frequency of negative emotion-related words shows little if any decline...
December 2, 2016: Cognition & Emotion
https://www.readbyqxmd.com/read/27910294/medication-management-in-the-older-adult-a-narrative-exploration
#5
Johnanna Hernandez
BACKGROUND AND PURPOSE: The purpose of this study was to characterize the meaning nurse practitioners (NPs) ascribed to personal experiences providing care to older adults who take multiple medications to manage complex conditions. The study illuminated the NP experience in caring for the older adult while addressing the complexities of medication management through narrative stories in practice. METHODS: NPs self-identifying as caring for older adults were interviewed (N=15)...
December 2, 2016: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/27910252/memory-performance-on-the-story-recall-test-and-prediction-of-cognitive-dysfunction-progression-in-mild-cognitive-impairment-and-alzheimer-s-dementia
#6
Jong-Hwan Park, Hyuntae Park, Sang Wuk Sohn, Sungjae Kim, Kyung Won Park
AIM: To determine the factors that influence diagnosis and differentiation of patients with mild cognitive impairment (MCI) and Alzheimer's dementia (AD) by comparing memory test results at baseline with those at 1-2-year follow up. METHODS: We consecutively recruited 23 healthy participants, 44 MCI patients and 27 patients with very mild AD according to the National Institute of Neurological and Communicative Diseases and Stroke/Alzheimer's Disease and Related Disorder Association criteria for probable Alzheimer's disease and Petersen's clinical diagnostic criteria...
December 1, 2016: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/27909857/privacy-autonomy-and-public-policy-french-and-north-american-perspectives
#7
Jennifer Merchant
This article raises the question of whether in both the United States and in France, an individual's autonomy and private decision-making right(s) in matters of health care and access to reproductive technologies can be conciliated with the general interest, and more specifically, the role of the State. Can a full-fledged right to privacy, the ability to exercise one's autonomy, exist alongside the general interest, and depend neither on financial resources like in the United States nor on centralised government decisions or the medical hierarchy like in France? The contrast between these two modern democracies justify the importance of comparing them...
December 2, 2016: Theoretical Medicine and Bioethics
https://www.readbyqxmd.com/read/27909495/the-wearable-cardioverter-defibrillator-toy-or-tool
#8
REVIEW
David Duncker Md, Christian Veltmann Md
After the success story of implantable cardioverter/defibrillator systems, prevention of sudden cardiac death (SCD) remains one of the main duties in cardiology. For patients with unkown or transient risk profile for SCD, a wearable cardioverter/defibrillator (WCD) has been established for temporary and effective prevention of sudden arrhythmic death. Several studies have shown safety and efficacy of the WCD, even though randomized studies proving a mortality benefit are still lacking. This review provides an overview of actual WCD data and usage, special indications and possible risks and complications...
April 2016: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/27908094/the-effects-of-physiological-adjustments-on-the-perceptual-and-acoustical-characteristics-of-vibrato-as-a-model-of-vocal-tremor
#9
Rosemary A Lester-Smith, Brad H Story
The purpose of this study was to investigate the effects of physiological adjustments on listeners' perception of the magnitude of modulation of voice and to determine the characteristics of the acoustical modulations that explained listeners' judgments. This research was carried out using singers producing vibrato as a model of vocal tremor. Twenty healthy adults participated in a perceptual study involving pair-comparisons of the magnitude of "shakiness" with singers' samples, which differed by fundamental frequency, vocal quality, and vowel...
November 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/27907818/reactive-dissociative-experiences-in-response-to-acute-increases-in-shame-feelings
#10
Martin J Dorahy, Hadyn McKendry, Amber Scott, Kumar Yogeeswaran, Andy Martens, Donncha Hanna
Studies have not examined if a direct causal relationship exists between shame and dissociation. The current research examined whether increases in dissociation were evident following exposure to acute shame feelings induced via narrative scripts of shame-evoking situations. Following Gilbert's (1998) differentiation between external and internal shame, participants heard shame-inducing or emotionally neutral stories in conditions designed to heighten (1) external shame, (2) internal shame or (3) general shame...
November 15, 2016: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/27906967/platinum-ii-iodido-complexes-of-7-azaindoles-with-significant-antiproliferative-effects-an-old-story-revisited-with-unexpected-outcomes
#11
Pavel Štarha, Ján Vančo, Zdeněk Trávníček, Jan Hošek, Jarmila Klusáková, Zdeněk Dvořák
A series of platinum(II) diiodido complexes containing 7-azaindole derivatives, having the general formula cis-[PtI2(naza)2] (1-8), has been prepared and thoroughly characterized, including X-ray structure analysis of cis-[PtI2(2Me4Claza)2]∙DMF (8∙DMF; 2Me4Claza = 2-methyl-4-chloro-7-azaindole). Complexes showed high in vitro cytotoxicity against nine human cancer cell lines (IC50 ranging from 0.4 to 12.8 μM), including the cisplatin-resistant ovarian cancer cell line (A2780R; IC50 = 1.0-3.5 μM). The results of in vivo testing, using the L1210 lymphocytic leukaemia model, at the equimolar doses of Pt with cisplatin (2 mg/kg) confirmed the activity of complex 8 comparable to cisplatin...
2016: PloS One
https://www.readbyqxmd.com/read/27906520/construction-of-the-human-forebrain
#12
REVIEW
Terry L Jernigan, Joan Stiles
The adult human brain is arguably the most complex of biological systems. It contains 86 billion neurons (the information processing cells of the brain) and many more support cells. The neurons, with the assistance of the support cells, form trillions of connections creating complex, interconnected neural networks that support all human thought, feeling, and action. A challenge for modern neuroscience is to provide a model that accounts for this exquisitely complex and dynamic system. One fundamental part of this model is an account of how the human brain develops...
December 1, 2016: Wiley Interdisciplinary Reviews. Cognitive Science
https://www.readbyqxmd.com/read/27905328/the-impact-factor-story-part-ii
#13
EDITORIAL
Sundaram Natarajan
No abstract text is available yet for this article.
October 2016: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/27904476/impairment-of-the-nerve-growth-factor-pathway-driving-amyloid-accumulation-in-cholinergic-neurons-the-incipit-of-the-alzheimer-s-disease-story
#14
REVIEW
Viviana Triaca, Pietro Calissano
The current idea behind brain pathology is that disease is initiated by mild disturbances of common physiological processes. Overtime, the disruption of the neuronal homeostasis will determine irreversible degeneration and neuronal apoptosis. This could be also true in the case of nerve growth factor (NGF) alterations in sporadic Alzheimer's disease (AD), an age-related pathology characterized by cholinergic loss, amyloid plaques and neurofibrillary tangles. In fact, the pathway activated by NGF, a key neurotrophin for the metabolism of basal forebrain cholinergic neurons (BFCN), is one of the first homeostatic systems affected in prodromal AD...
October 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/27903727/predicting-when-in-discourse-engages-the-human-dorsal-auditory-stream-an-fmri-study-using-naturalistic-stories
#15
Katerina Danae Kandylaki, Arne Nagels, Sarah Tune, Tilo Kircher, Richard Wiese, Matthias Schlesewsky, Ina Bornkessel-Schlesewsky
: The hierarchical organization of human cortical circuits integrates information across different timescales via temporal receptive windows, which increase in length from lower to higher levels of the cortical hierarchy (Hasson et al., 2015). A recent neurobiological model of higher-order language processing (Bornkessel-Schlesewsky et al., 2015) posits that temporal receptive windows in the dorsal auditory stream provide the basis for a hierarchically organized predictive coding architecture (Friston and Kiebel, 2009)...
November 30, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27903546/positron-emission-tomography-fluorine-18-labeled-2-deoxy-2-fluoro-d-glucose-tells-a-complicated-story-in-the-aortic-aneurysm-wall
#16
EDITORIAL
John A Curci, Joshua A Beckman
No abstract text is available yet for this article.
November 2016: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/27903543/the-denser-the-merrier-the-developing-story-of-vascular-calcification
#17
EDITORIAL
Márcio Sommer Bittencourt
No abstract text is available yet for this article.
November 2016: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/27903509/best-predictors-of-stroke-outcome-and-other-stories
#18
(no author information available yet)
No abstract text is available yet for this article.
November 30, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27903171/a-common-struggle-a-personal-journey-through-the-past-and-future-of-mental-illness-and-addiction-resilience-two-sisters-and-a-story-of-mental-illnessby-patrick-j-kennedy-and-stephen-fried-new-york-blue-ridge-press-2015-422-pages-by-jessie-close-with-pete-early
#19
https://www.readbyqxmd.com/read/27902877/the-discovery-of-electrokinetic-phenomena-setting-the-record-straight
#20
REVIEW
Christian J C Biscombe
Electro-osmosis and electrophoresis were discovered by F. F. Reuss in Moscow in 1807. Or so the story goes. This essay critically examines the contributions of three scientists to the discovery of electrokinetic phenomena. The evidence suggests that Reuss did indeed discover electro-osmosis, which takes its name (indirectly) from the work of Porrett. Contrary to current consensus, Gautherot made the earliest known observation of electrophoresis.
November 30, 2016: Angewandte Chemie
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