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https://www.readbyqxmd.com/read/29352601/regulating-needs-exploring-the-role-of-insulin-like-growth-factor-2-signalling-in-materno-fetal-resource-allocation
#1
Amanda Nancy Sferruzzi-Perri
During pregnancy, the fetus requires nutrients supplied by the mother to grow and develop. However, the mother also requires sufficient resources to support the pregnancy, as well as, to maintain her health. Failure to regulate resource allocation between the mother and fetus can lead to pregnancy complications with immediate and life-long consequences for maternal and offspring health. This review explores the role of insulin-like growth factor (IGF)-2 in regulating materno-fetal resource allocation, particularly via its regulation of placental development and function...
January 11, 2018: Placenta
https://www.readbyqxmd.com/read/29340812/partial-amniotic-carbon-dioxide-insufflation-paci-during-minimally-invasive-fetoscopic-interventions-on-fetuses-with-spina-bifida-aperta
#2
Miriam Ziemann, Rolf Fimmers, Anastasiia Khaleeva, Rainer Schürg, Markus A Weigand, Thomas Kohl
BACKGROUND: Percutaneous partial amniotic carbon dioxide insufflation (PACI) is one of the most important means for improving visualization during minimally invasive fetoscopic surgery of fetal spina bifida. The purpose of the present study was to analyze maternal and fetal safety aspects of PACI in a recent patient cohort and to present management improvements. METHODS: PACI under general materno-fetal anesthesia was performed during 65 interventions for fetoscopic patch coverage of fetal spina bifida aperta between 21 + 0 and 29 + 1 weeks of gestation...
January 16, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29335435/placental-morphology-is-associated-with-maternal-depressive-symptoms-during-pregnancy-and-toddler-psychiatric-problems
#3
Marius Lahti-Pulkkinen, Melissa Jane Cudmore, Eva Haeussner, Christoph Schmitz, Anu-Katriina Pesonen, Esa Hämäläinen, Pia M Villa, Susanna Mehtälä, Eero Kajantie, Hannele Laivuori, Rebecca M Reynolds, Hans-Georg Frank, Katri Räikkönen
Maternal depressive symptoms during pregnancy predict increased psychiatric problems in children. The underlying biological mechanisms remain unclear. Hence, we examined whether alterations in the morphology of 88 term placentas were associated with maternal depressive symptoms during pregnancy and psychiatric problems in 1.9-3.1-years old (Mean = 2.1 years) toddlers. Maternal depressive symptoms were rated biweekly during pregnancy with the Center of Epidemiological Studies Depression Scale (n = 86)...
January 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29243058/does-prophylactic-ondansetron-reduce-norepinephrine-consumption-in-patients-undergoing-cesarean-section-with-spinal-anesthesia
#4
Feride Karacaer, Ebru Biricik, İlker Ünal, Selim Büyükkurt, Hakkı Ünlügenç
PURPOSE: Spinal anesthesia-induced hypotension (SAIH) during cesarean delivery is not rare and frequently leads to materno-fetal discrepancy and collapse. More recently, norepinephrine has been proposed for the prevention and treatment of SAIH with fewer tendencies to decrease heart rate and cardiac output. Ondansetron has been reported to reduce the incidence of SAIH in patients undergoing cesarean section. The aim of the present study was to assess the effect of prophylactic ondansetron on the incidence of SAIH, norepinephrine consumption, and adverse effects...
December 14, 2017: Journal of Anesthesia
https://www.readbyqxmd.com/read/28962692/expression-and-function-of-nod-like-receptors-by-human-term-gestation-associated-tissues
#5
Aled H Bryant, Ryan J Bevan, Samantha Spencer-Harty, Louis M Scott, Ruth H Jones, Catherine A Thornton
INTRODUCTION: Nucleotide-binding oligomerization domain (NOD)-like receptors or NOD-like receptors (NLRs) have been implicated in several disease pathologies associated with inflammation. Since local and systemic inflammation is a hallmark of both term and preterm labour, a role for NLRs at the materno-fetal interface has been postulated. METHODS: Gene expression and immunolocalisation of NLR family members in human placenta, choriodecidua, and amnion were examined...
October 2017: Placenta
https://www.readbyqxmd.com/read/28888333/maternal-long-chain-polyunsaturated-fatty-acid-status-and-pregnancy-complications
#6
REVIEW
Nisha Wadhwani, Vidya Patil, Sadhana Joshi
Maternal nutrition plays a crucial role in influencing fetal growth and birth outcome. Any nutritional insult starting several weeks before pregnancy and during critical periods of gestation is known to influence fetal development and increase the risk for diseases during later life. Literature suggests that chronic adult diseases may have their origin during early life - a concept referred to as Developmental Origins of Health and Disease (DOHaD) which states that adverse exposures early in life "program" risks for later chronic disorders...
August 15, 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/28747528/embryo-implantation-evolved-from-an-ancestral-inflammatory-attachment-reaction
#7
Oliver W Griffith, Arun R Chavan, Stella Protopapas, Jamie Maziarz, Roberto Romero, Gunter P Wagner
The molecular changes that support implantation in eutherian mammals are necessary to establish pregnancy. In marsupials, pregnancy is relatively short, and although a placenta does form, it is present for only a few days before parturition. However, morphological changes in the uterus of marsupials at term mimic those that occur during implantation in humans and mice. We investigated the molecular similarity between term pregnancy in the marsupials and implantation in eutherian mammals using the gray short-tailed opossum (Monodelphis domestica) as a model...
August 8, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28712670/production-and-regulation-of-interleukin-1-family-cytokines-at-the-materno-fetal-interface
#8
Louis M Scott, Aled H Bryant, April Rees, Billy Down, Ruth H Jones, Catherine A Thornton
IL-1 family members regulate innate immune responses, are produced by gestation-associated tissues, and have a role in healthy and adverse pregnancy outcomes. To better understand their role at the materno-fetal interface we used a human tissue explant model to map lipopolysaccharide (LPS)-stimulated production of IL-1α, IL-1β, IL-18, IL-33, IL-1Ra, IL-18BPa, ST2 and IL-1RAcP by placenta, choriodecidua and amnion. Caspase-dependent processing of IL-1α, IL-1β, IL-18, and IL-33 and the ability of IL-1α, IL-1β, IL-18, and IL-33 to regulate the production of IL-1RA, IL-18BPa, ST2 and IL-1RAcP was also determined...
July 13, 2017: Cytokine
https://www.readbyqxmd.com/read/28692229/-zika-virus-from-research-to-vaccine
#9
Manon Vouga, Marco P Alves, Isabelle Eperon, Gilles Eperon, Laurence Rochat, Roland Sahli, Didier Musso, David Baud
Zika virus has recently emerged as new teratogenic agent. Research is drastically increasing to allow a better comprehension of the role of this emerging virus in the induction of fetal cerebral anomalies. Several epidemiological and microbiological aspects may explain a higher virulence of the current strain. Various animal models have been developed and confirm the materno-fetal transmission as well as the induction of cerebral development's disorders. In parallel, various companies are working to develop a vaccine and antiviral medicine against Zika virus...
October 26, 2016: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28679758/a-cell-fusion-based-screening-method-identifies-glycosylphosphatidylinositol-anchored-protein-ly6e-as-the-receptor-for-mouse-endogenous-retroviral-envelope-syncytin-a
#10
Agathe Bacquin, Caroline Bireau, Maxime Tanguy, Charlotte Romanet, Cécile Vernochet, Anne Dupressoir, Thierry Heidmann
Syncytin genes are envelope genes of retroviral origin that have been exapted for a role in placentation. They are involved in the formation of a syncytial structure (the syncytiotrophoblast) at the fetomaternal interface via their fusogenic activity. The mouse placenta is unique among placental mammals since the fetomaternal interface comprises two syncytiotrophoblast layers (ST-I and ST-II) instead of one, as observed in humans and all other hemochorial placentae. Each layer specifically expresses a distinct mouse syncytin, namely, syncytin-A (SynA) for ST-I and syncytin-B (SynB) for ST-II, which have been shown to be essential to placentogenesis and embryo survival...
September 15, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28627202/maternal-underweight-and-perinatal-outcomes-a-restrospective-cohort-study
#11
Ángel Vilar Sánchez, Juan Jesús Fernández Alba, María Del Carmen González Macías, María Del Carmen Paublete Herrera, Concepción Carnicer Fuentes, Florentino Carral San Laureano, Rafael Torrejón Cardoso, Luis Javier Moreno Corral
Introduction: Some studies have linked maternal underweight with adverse perinatal outcomes such as spontaneous abortion, abruptio placentae, small for gestational age newborn, intrauterine growth retardation and preterm birth. Objective: To determine the influence of maternal underweight in the onset of labor, route of delivery, birth weight, Apgar score and preterm birth. Methods: Retrospective cohort study. We included pregnant women from the Hospital Universitario de Puerto Real. Period of study: 2002-2011...
June 5, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28591252/impact-of-the-use-of-different-diagnostic-criteria-in-the-prevalence-of-dyslipidemia-in-pregnant-women
#12
Alina Coutinho Rodrigues Feitosa, Luciana Tedgue Barreto, Isabela Matos da Silva, Felipe Freire da Silva, Gilson Soares Feitosa
Background: There is a physiologic elevation of total cholesterol (TC) and triglycerides (TG) during pregnancy. Some authors define dyslipidemia (DLP) in pregnant women when TC, LDL and TG concentrations are above the 95th percentile (p95%) and HDL concentration is below the 5th percentile (P5%) for gestational age (GA). Objective: To compare the prevalence of DLP in pregnant women using percentiles criteria with the V Brazilian Guidelines on Dyslipidemia and the association with maternal and fetal outcomes...
July 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28561420/cab4b-the-first-human-platelet-antigen-carried-by-glycoprotein-ix-discovered-in-a-context-of-severe-neonatal-thrombocytopenia
#13
V Jallu, T Beranger, F Bianchi, C Casale, C Chenet, N Ferre, S Philippe, J Quesne, C Martageix, R Petermann
Essentials Life-threatening maternofetal thrombocytopenias mostly depend on αIIb β3 antigens. We performed serological, genomic and in vitro studies of two life-threatening thrombocytopenias. Identification of a c.368C>T variation leading to Pro123Leu substitution in GPIX. A rare GPIX variant reported in a genomic database define a new alloantigen. SUMMARY: Background After three miscarriages, a 39-year-old woman gave birth, with a 1-year interval, to two severely thrombocytopenic neonates (4 ×10(9) L(-1) and 33 ×10(9) L(-1) ) with intracranial hemorrhages...
August 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28508343/cytomegalovirus-infection-in-pregnancy
#14
REVIEW
Karl Oliver Kagan, Klaus Hamprecht
PURPOSE: Due to the severe risk of long-term sequelae, prenatal cytomegalovirus infection is of particular importance amongst intrauterine viral infections. This review summarizes the current knowledge about CMV infection in pregnancy. METHODS: A search of the Medline and Embase database was done for articles about CMV infection in pregnany. We performed a detailed review of the literature in view of diagnosis, epidemiology and management of CMV infection in pregnancy...
July 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28215301/neurotrophic-factors-and-maternal-nutrition-during-pregnancy
#15
REVIEW
M Dhobale
Maternal nutrition is one of the major determinants of pregnancy outcome. It has been suggested that reduced intakes or lack of specific nutrients during pregnancy influences the length of gestation, proper placental and fetal growth during pregnancy. Maternal nutrition, particularly micronutrients such as folate and vitamin B12, and long-chain polyunsaturated fatty acids (LCPUFA) are the major determinants of the one carbon cycle and are suggested to be at the heart of intrauterine programming of diseases in adult life...
2017: Vitamins and Hormones
https://www.readbyqxmd.com/read/28188612/hepatitis-b-immunoglobulin-during-pregnancy-for-prevention-of-mother-to-child-transmission-of-hepatitis-b-virus
#16
REVIEW
Ahizechukwu C Eke, George U Eleje, Uzoamaka A Eke, Yun Xia, Jiao Liu
BACKGROUND: Hepatitis is a viral infection of the liver. It is mainly transmitted between people through contact with infected blood, frequently from mother to baby in-utero. Hepatitis B poses significant risk to the fetus and up to 85% of infants infected by their mothers at birth develop chronic hepatitis B virus (HBV) infection. Hepatitis B immunoglobulin (HBIG) is a purified solution of human immunoglobulin that could be administered to the mother, newborn, or both. HBIG offers protection against HBV infection when administered to pregnant women who test positive for hepatitis B envelope antigen (HBeAg) or hepatitis B surface antigen (HBsAg), or both...
February 11, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28169502/physiological-adaptation-of-maternal-plasma-volume-during-pregnancy-a-systematic-review-and-meta-analysis
#17
REVIEW
S de Haas, C Ghossein-Doha, S M J van Kuijk, J van Drongelen, M E A Spaanderman
OBJECTIVE: To describe the physiological pattern of gestational plasma volume adjustments in normal singleton pregnancy and compare this with the pattern in pregnancies complicated by pregnancy-induced hypertension, pre-eclampsia or fetal growth restriction. METHODS: We performed a meta-analysis of the current literature on plasma volume adjustments during physiological and complicated pregnancies. Literature was retrieved from PubMed (NCBI) and EMBASE (Ovid) databases...
February 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28161062/localisation-of-epidermal-growth-factor-egf-its-specific-receptor-egf-r-and-aromatase-at-the-materno-fetal-interface-during-placentation-in-the-pregnant-mare
#18
W R Twink Allen, Susan Gower, Sandra Wilsher
INTRODUCTION: Implantation and placentation in the mare does not commence until as late as day 40 after ovulation. The reasons for this and the growth factors and/or hormones which drive placentation when it does finally occur are of considerable academic and practical interest. METHOD: Placental interface tissues recovered from 11 accurately aged and perfused-fixed horse uteri between 20 and 68 days of gestation were stained immunocytochemically for Epidermal Growth Factor (EGF), its specific receptor (EGF-R) and for the steroid hormone enzyme, aromatase...
February 2017: Placenta
https://www.readbyqxmd.com/read/28088214/determinants-and-materno-fetal-outcomes-related-to-cesarean-section-delivery-in-private-and-public-hospitals-in-low-and-middle-income-countries-a-systematic-review-and-meta-analysis-protocol
#19
Idrissa Beogo, Bomar Mendez Rojas, Marie-Pierre Gagnon
BACKGROUND: Despite the well-established morbidity, mortality, long-term effects, and unnecessary extra-cost burden associated with cesarean section delivery (CSD) worldwide, its rate has grown exponentially. This has become a great topical challenge for the international healthcare community and individual countries. Estimated at three times the acceptable rate as defined by the World Health Organization in 1985, the continued upward trend has been fuelled by higher income countries...
January 14, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28081266/human-extravillous-trophoblasts-penetrate-decidual-veins-and-lymphatics-before-remodeling-spiral-arteries-during-early-pregnancy
#20
Nannan He, Liesbeth van Iperen, Danielle de Jong, Karoly Szuhai, Frans M Helmerhorst, Lucette A J van der Westerlaken, Susana M Chuva de Sousa Lopes
In humans, the defective invasion of the maternal endometrium by fetal extravillous trophoblasts (EVTs) can lead to insufficient perfusion of the placenta, resulting in pregnancy complications that can put both mother and baby at risk. To study the invasion of maternal endometrium between (W)5.5-12 weeks of gestation by EVTs, we combined fluorescence in situ hybridization, immunofluorescence and immunohistochemistry to determine the presence of (male) EVTs in the vasculature of the maternal decidua. We observed that interstitial mononuclear EVTs directly entered decidual veins and lymphatics from W5...
2017: PloS One
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