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https://www.readbyqxmd.com/read/29913334/abnormal-placentation-current-evidence-and-review-of-the-literature
#1
REVIEW
Ioannis G Papanikolaou, Ekaterini Domali, George Daskalakis, Marianna Theodora, Eirini Telaki, Petros Drakakis, Dimitrios Loutradis
Abnormal placentation often requires the involvement of a multidisciplinary team of medical caregivers. Practicing Obstetrics is a challenging and skillful duty. This is more obvious in cases of abnormal placentation, which represents one of the most dangerous and complex clinical conditions in materno-fetal medicine. Pathological placentation involves position and invasion abnormalities and represents a serious and potentially life-threatening condition for both the pregnant woman and the fetus. The dramatic increase in cesarean section rates is an important factor which could explain the rapid raise in abnormal placentation cases, which were considered rare a few years ago...
June 5, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29761476/comparison-of-materno-fetal-predictors-and-short-term-outcomes-between-early-and-late-onset-pre-eclampsia-in-the-low-income-setting-of-douala-cameroon
#2
Charlotte Tchente Nguefack, Annabel Ako Mangwi, Anastase Dzudie Tamdja, Théophile Nana Njamen, Paul Nkemtendong Tolefack, Emile Mboudou
OBJECTIVE: To describe and compare materno-fetal predictors and short-term outcomes of early onset pre-eclampsia (EOPE) and late onset pre-eclampsia (LOPE) in Douala, Cameroon. METHODS: The present prospective hospital-based cross-sectional study included women with pre-eclampsia attending obstetric units at four hospitals in Douala between December 1, 2016, and April 30, 2017. To determine maternal predictors, sociodemographic and medical data were recorded using a pretested questionnaire...
May 14, 2018: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29758177/the-efficacy-of-antenatal-steroid-therapy-is-dependent-on-the-duration-of-low-concentration-fetal-exposure-evidence-from-a-sheep-model-of-pregnancy
#3
Matthew W Kemp, Masatoshi Saito, Haruo Usuda, Shimpei Watanabe, Shinichi Sato, Takushi Hanita, Yusaku Kumagai, Timothy J Molloy, Michael Clarke, Peter J Eddershaw, Gabrielle C Musk, Augusto Schmidt, Demelza Ireland, Lucy Furfaro, Matthew S Payne, John P Newnham, Alan H Jobe
OBJECTIVE: Antenatal corticosteroids (ANS) are among the most important and widely used interventions to improve outcomes for preterm infants. ANS dosing regimens remain un-optimized and without maternal weight-adjusted dosing. We, and others, have hypothesised that once a low concentration of materno-fetal steroid exposure is achieved and maintained, the duration of the steroid exposure determines treatment efficacy. Using a sheep model of pregnancy, we tested the relationship between steroid dose, and duration of exposure, and treatment efficacy...
May 9, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29756650/stillbirth-rates-across-three-ape-species-in-accredited-american-zoos
#4
Sana T Saiyed, Rebecca C Liubicich, Mason Fidino, Stephen R Ross
Stillbirths, or births of infants that died in the womb, represent a failure of the materno-feto-placental unit to maintain a suitable fetal environment. Typical studies of nonhuman primate (NHP) stillbirth patterns are primarily descriptive and focus on macaques (genus Macaca). Thus, less is known about other NHP species and rarer still are studies that examine possible biological factors that influence stillbirth rates across taxa. To examine possible contributors to stillbirths in great apes, we analyzed 36 years (1980-2016) of historical data documenting births of zoo-housed chimpanzees (Pan troglodytes, N = 391), western lowland gorillas (Gorilla gorilla gorilla, N = 491), and orangutans (Pongo spp, N = 307) in accredited zoological parks in the United States...
May 14, 2018: American Journal of Primatology
https://www.readbyqxmd.com/read/29733064/apoyo-social-y-marginaci%C3%A3-n-como-determinantes-de-la-atenci%C3%A3-n-prenatal-en-mujeres-con-seguridad-social-en-m%C3%A3-xico
#5
Maritza Maldonado-Cisneros, Oswaldo Sinoe Medina-Gómez
Introducción: La atención prenatal garantiza resultados favorables para la salud materno-fetal, para ello es necesario que se realice de forma precoz, periódica, completa y con alta cobertura. Objetivo: Conocer los determinantes sociales para la atención prenatal en mujeres derechohabientes del Instituto Mexicano del Seguro Social durante 2014. Método: Estudio transversal en el que se analizó la asociación de condiciones sociales, apoyo social y funcionalidad familiar con atención prenatal inadecuada...
2018: Gaceta Médica de México
https://www.readbyqxmd.com/read/29621962/maternal-hair-and-neonatal-meconium-to-assess-gestational-consumption-and-prenatal-exposure-to-drugs-of-abuse-and-psychoactive-drugs
#6
Laura Cortes, Laura Almeida, Sally Sabra, Marta Muniesa, Francesco Paolo Busardo, Oscar Garcia-Algar, Maria Dolores Gomez-Roig
BACKGROUND: In the last two decades, the consumption of drugs of abuse among women of childbearing age has experienced a significant increase and results from analyses of surveys concerning maternal intake of psychoactive prescription drugs during pregnancy indicate that the rates of intake are increasing each year. Analyses of biological matrices such as maternal hair and neonatal meconium have recently been used for assessment of gestational consumption and consequent prenatal exposure to drugs of abuse in high-risk groups of women METHODS: Maternal hair and neonatal meconium were analyzed by validated chromatographic mass spectrometric methodologies to disclose gestational use of drugs of abuse and psychoactive prescription drugs and consequent prenatal exposure in a cohort of 513 mother-newborn dyads at the Sant Joan de Déu Barcelona Hospital, Spain, during 2012- 2013...
April 5, 2018: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/29499643/identification-of-placental-nutrient-transporters-associated-with-intrauterine-growth-restriction-and-pre-eclampsia
#7
Xiao Huang, Pascale Anderle, Lu Hostettler, Marc U Baumann, Daniel V Surbek, Edgar C Ontsouka, Christiane Albrecht
BACKGROUND: Gestational disorders such as intrauterine growth restriction (IUGR) and pre-eclampsia (PE) are main causes of poor perinatal outcomes worldwide. Both diseases are related with impaired materno-fetal nutrient transfer, but the crucial transport mechanisms underlying IUGR and PE are not fully elucidated. In this study, we aimed to identify membrane transporters highly associated with transplacental nutrient deficiencies in IUGR/PE. RESULTS: In silico analyses on the identification of differentially expressed nutrient transporters were conducted using seven eligible microarray datasets (from Gene Expression Omnibus), encompassing control and IUGR/PE placental samples...
March 2, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29485737/hypertension-in-pregnancy-taking-cues-from-pathophysiology-for-clinical-practice
#8
REVIEW
Ruxandra I Sava, Keith L March, Carl J Pepine
Pregnancy-related hypertension (PHTN) syndromes are a frequent and potentially deadly complication of pregnancy, while also negatively impacting the lifelong health of the mother and child. PHTN appears in women likely to develop hypertension later in life, with the stress of pregnancy unmasking a subclinical hypertensive phenotype. However, distinguishing between PHTN and chronic hypertension is essential for optimal management. Preeclampsia (PE) is linked to potentially severe outcomes and lacks effective treatments due to poorly understood mechanisms...
February 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29352601/regulating-needs-exploring-the-role-of-insulin-like-growth-factor-2-signalling-in-materno-fetal-resource-allocation
#9
Amanda Nancy Sferruzzi-Perri
During pregnancy, the fetus requires nutrients supplied by the mother to grow and develop. However, the mother also requires sufficient resources to support the pregnancy, as well as, to maintain her health. Failure to regulate resource allocation between the mother and fetus can lead to pregnancy complications with immediate and life-long consequences for maternal and offspring health. This review explores the role of insulin-like growth factor (IGF)-2 in regulating materno-fetal resource allocation, particularly via its regulation of placental development and function...
April 2018: Placenta
https://www.readbyqxmd.com/read/29340812/partial-amniotic-carbon-dioxide-insufflation-paci-during-minimally-invasive-fetoscopic-interventions-on-fetuses-with-spina-bifida-aperta
#10
Miriam Ziemann, Rolf Fimmers, Anastasiia Khaleeva, Rainer Schürg, Markus A Weigand, Thomas Kohl
BACKGROUND: Percutaneous partial amniotic carbon dioxide insufflation (PACI) is one of the most important means for improving visualization during minimally invasive fetoscopic surgery of fetal spina bifida. The purpose of the present study was to analyze maternal and fetal safety aspects of PACI in a recent patient cohort and to present management improvements. METHODS: PACI under general materno-fetal anesthesia was performed during 65 interventions for fetoscopic patch coverage of fetal spina bifida aperta between 21 + 0 and 29 + 1 weeks of gestation...
January 16, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29335435/placental-morphology-is-associated-with-maternal-depressive-symptoms-during-pregnancy-and-toddler-psychiatric-problems
#11
Marius Lahti-Pulkkinen, Melissa Jane Cudmore, Eva Haeussner, Christoph Schmitz, Anu-Katriina Pesonen, Esa Hämäläinen, Pia M Villa, Susanna Mehtälä, Eero Kajantie, Hannele Laivuori, Rebecca M Reynolds, Hans-Georg Frank, Katri Räikkönen
Maternal depressive symptoms during pregnancy predict increased psychiatric problems in children. The underlying biological mechanisms remain unclear. Hence, we examined whether alterations in the morphology of 88 term placentas were associated with maternal depressive symptoms during pregnancy and psychiatric problems in 1.9-3.1-years old (Mean = 2.1 years) toddlers. Maternal depressive symptoms were rated biweekly during pregnancy with the Center of Epidemiological Studies Depression Scale (n = 86)...
January 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29243058/does-prophylactic-ondansetron-reduce-norepinephrine-consumption-in-patients-undergoing-cesarean-section-with-spinal-anesthesia
#12
Feride Karacaer, Ebru Biricik, İlker Ünal, Selim Büyükkurt, Hakkı Ünlügenç
PURPOSE: Spinal anesthesia-induced hypotension (SAIH) during cesarean delivery is not rare and frequently leads to materno-fetal discrepancy and collapse. More recently, norepinephrine has been proposed for the prevention and treatment of SAIH with fewer tendencies to decrease heart rate and cardiac output. Ondansetron has been reported to reduce the incidence of SAIH in patients undergoing cesarean section. The aim of the present study was to assess the effect of prophylactic ondansetron on the incidence of SAIH, norepinephrine consumption, and adverse effects...
February 2018: Journal of Anesthesia
https://www.readbyqxmd.com/read/28962692/expression-and-function-of-nod-like-receptors-by-human-term-gestation-associated-tissues
#13
Aled H Bryant, Ryan J Bevan, Samantha Spencer-Harty, Louis M Scott, Ruth H Jones, Catherine A Thornton
INTRODUCTION: Nucleotide-binding oligomerization domain (NOD)-like receptors or NOD-like receptors (NLRs) have been implicated in several disease pathologies associated with inflammation. Since local and systemic inflammation is a hallmark of both term and preterm labour, a role for NLRs at the materno-fetal interface has been postulated. METHODS: Gene expression and immunolocalisation of NLR family members in human placenta, choriodecidua, and amnion were examined...
October 2017: Placenta
https://www.readbyqxmd.com/read/28888333/maternal-long-chain-polyunsaturated-fatty-acid-status-and-pregnancy-complications
#14
REVIEW
Nisha Wadhwani, Vidya Patil, Sadhana Joshi
Maternal nutrition plays a crucial role in influencing fetal growth and birth outcome. Any nutritional insult starting several weeks before pregnancy and during critical periods of gestation is known to influence fetal development and increase the risk for diseases during later life. Literature suggests that chronic adult diseases may have their origin during early life - a concept referred to as Developmental Origins of Health and Disease (DOHaD) which states that adverse exposures early in life "program" risks for later chronic disorders...
August 15, 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/28747528/embryo-implantation-evolved-from-an-ancestral-inflammatory-attachment-reaction
#15
Oliver W Griffith, Arun R Chavan, Stella Protopapas, Jamie Maziarz, Roberto Romero, Gunter P Wagner
The molecular changes that support implantation in eutherian mammals are necessary to establish pregnancy. In marsupials, pregnancy is relatively short, and although a placenta does form, it is present for only a few days before parturition. However, morphological changes in the uterus of marsupials at term mimic those that occur during implantation in humans and mice. We investigated the molecular similarity between term pregnancy in the marsupials and implantation in eutherian mammals using the gray short-tailed opossum (Monodelphis domestica) as a model...
August 8, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28712670/production-and-regulation-of-interleukin-1-family-cytokines-at-the-materno-fetal-interface
#16
Louis M Scott, Aled H Bryant, April Rees, Billy Down, Ruth H Jones, Catherine A Thornton
IL-1 family members regulate innate immune responses, are produced by gestation-associated tissues, and have a role in healthy and adverse pregnancy outcomes. To better understand their role at the materno-fetal interface we used a human tissue explant model to map lipopolysaccharide (LPS)-stimulated production of IL-1α, IL-1β, IL-18, IL-33, IL-1Ra, IL-18BPa, ST2 and IL-1RAcP by placenta, choriodecidua and amnion. Caspase-dependent processing of IL-1α, IL-1β, IL-18, and IL-33 and the ability of IL-1α, IL-1β, IL-18, and IL-33 to regulate the production of IL-1RA, IL-18BPa, ST2 and IL-1RAcP was also determined...
November 2017: Cytokine
https://www.readbyqxmd.com/read/28692229/-zika-virus-from-research-to-vaccine
#17
Manon Vouga, Marco P Alves, Isabelle Eperon, Gilles Eperon, Laurence Rochat, Roland Sahli, Didier Musso, David Baud
Zika virus has recently emerged as new teratogenic agent. Research is drastically increasing to allow a better comprehension of the role of this emerging virus in the induction of fetal cerebral anomalies. Several epidemiological and microbiological aspects may explain a higher virulence of the current strain. Various animal models have been developed and confirm the materno-fetal transmission as well as the induction of cerebral development's disorders. In parallel, various companies are working to develop a vaccine and antiviral medicine against Zika virus...
October 26, 2016: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28679758/a-cell-fusion-based-screening-method-identifies-glycosylphosphatidylinositol-anchored-protein-ly6e-as-the-receptor-for-mouse-endogenous-retroviral-envelope-syncytin-a
#18
Agathe Bacquin, Caroline Bireau, Maxime Tanguy, Charlotte Romanet, Cécile Vernochet, Anne Dupressoir, Thierry Heidmann
Syncytin genes are envelope genes of retroviral origin that have been exapted for a role in placentation. They are involved in the formation of a syncytial structure (the syncytiotrophoblast) at the fetomaternal interface via their fusogenic activity. The mouse placenta is unique among placental mammals since the fetomaternal interface comprises two syncytiotrophoblast layers (ST-I and ST-II) instead of one, as observed in humans and all other hemochorial placentae. Each layer specifically expresses a distinct mouse syncytin, namely, syncytin-A (SynA) for ST-I and syncytin-B (SynB) for ST-II, which have been shown to be essential to placentogenesis and embryo survival...
September 15, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28627202/maternal-underweight-and-perinatal-outcomes-a-restrospective-cohort-study
#19
Ángel Vilar Sánchez, Juan Jesús Fernández Alba, María Del Carmen González Macías, María Del Carmen Paublete Herrera, Concepción Carnicer Fuentes, Florentino Carral San Laureano, Rafael Torrejón Cardoso, Luis Javier Moreno Corral
Introduction: Some studies have linked maternal underweight with adverse perinatal outcomes such as spontaneous abortion, abruptio placentae, small for gestational age newborn, intrauterine growth retardation and preterm birth. Objective: To determine the influence of maternal underweight in the onset of labor, route of delivery, birth weight, Apgar score and preterm birth. Methods: Retrospective cohort study. We included pregnant women from the Hospital Universitario de Puerto Real. Period of study: 2002-2011...
June 5, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28591252/impact-of-the-use-of-different-diagnostic-criteria-in-the-prevalence-of-dyslipidemia-in-pregnant-women
#20
COMPARATIVE STUDY
Alina Coutinho Rodrigues Feitosa, Luciana Tedgue Barreto, Isabela Matos da Silva, Felipe Freire da Silva, Gilson Soares Feitosa
Background: There is a physiologic elevation of total cholesterol (TC) and triglycerides (TG) during pregnancy. Some authors define dyslipidemia (DLP) in pregnant women when TC, LDL and TG concentrations are above the 95th percentile (p95%) and HDL concentration is below the 5th percentile (P5%) for gestational age (GA). Objective: To compare the prevalence of DLP in pregnant women using percentiles criteria with the V Brazilian Guidelines on Dyslipidemia and the association with maternal and fetal outcomes...
July 2017: Arquivos Brasileiros de Cardiologia
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