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https://www.readbyqxmd.com/read/28215301/neurotrophic-factors-and-maternal-nutrition-during-pregnancy
#1
M Dhobale
Maternal nutrition is one of the major determinants of pregnancy outcome. It has been suggested that reduced intakes or lack of specific nutrients during pregnancy influences the length of gestation, proper placental and fetal growth during pregnancy. Maternal nutrition, particularly micronutrients such as folate and vitamin B12, and long-chain polyunsaturated fatty acids (LCPUFA) are the major determinants of the one carbon cycle and are suggested to be at the heart of intrauterine programming of diseases in adult life...
2017: Vitamins and Hormones
https://www.readbyqxmd.com/read/28188612/hepatitis-b-immunoglobulin-during-pregnancy-for-prevention-of-mother-to-child-transmission-of-hepatitis-b-virus
#2
REVIEW
Ahizechukwu C Eke, George U Eleje, Uzoamaka A Eke, Yun Xia, Jiao Liu
BACKGROUND: Hepatitis is a viral infection of the liver. It is mainly transmitted between people through contact with infected blood, frequently from mother to baby in-utero. Hepatitis B poses significant risk to the fetus and up to 85% of infants infected by their mothers at birth develop chronic hepatitis B virus (HBV) infection. Hepatitis B immunoglobulin (HBIG) is a purified solution of human immunoglobulin that could be administered to the mother, newborn, or both. HBIG offers protection against HBV infection when administered to pregnant women who test positive for hepatitis B envelope antigen (HBeAg) or hepatitis B surface antigen (HBsAg), or both...
February 11, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28169502/physiological-adaptation-of-maternal-plasma-volume-during-pregnancy-a-systematic-review-and-meta-analysis
#3
REVIEW
S de Haas, C Ghossein-Doha, S M J van Kuijk, J van Drongelen, M E A Spaanderman
OBJECTIVE: To describe the physiological pattern of gestational plasma volume adjustments in normal singleton pregnancy and compare this with the pattern in pregnancies complicated by pregnancy-induced hypertension, pre-eclampsia or fetal growth restriction. METHODS: We performed a meta-analysis of the current literature on plasma volume adjustments during physiological and complicated pregnancies. Literature was retrieved from PubMed (NCBI) and EMBASE (Ovid) databases...
February 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28161062/localisation-of-epidermal-growth-factor-egf-its-specific-receptor-egf-r-and-aromatase-at-the-materno-fetal-interface-during-placentation-in-the-pregnant-mare
#4
W R Twink Allen, Susan Gower, Sandra Wilsher
INTRODUCTION: Implantation and placentation in the mare does not commence until as late as day 40 after ovulation. The reasons for this and the growth factors and/or hormones which drive placentation when it does finally occur are of considerable academic and practical interest. METHOD: Placental interface tissues recovered from 11 accurately aged and perfused-fixed horse uteri between 20 and 68 days of gestation were stained immunocytochemically for Epidermal Growth Factor (EGF), its specific receptor (EGF-R) and for the steroid hormone enzyme, aromatase...
February 2017: Placenta
https://www.readbyqxmd.com/read/28088214/determinants-and-materno-fetal-outcomes-related-to-cesarean-section-delivery-in-private-and-public-hospitals-in-low-and-middle-income-countries-a-systematic-review-and-meta-analysis-protocol
#5
Idrissa Beogo, Bomar Mendez Rojas, Marie-Pierre Gagnon
BACKGROUND: Despite the well-established morbidity, mortality, long-term effects, and unnecessary extra-cost burden associated with cesarean section delivery (CSD) worldwide, its rate has grown exponentially. This has become a great topical challenge for the international healthcare community and individual countries. Estimated at three times the acceptable rate as defined by the World Health Organization in 1985, the continued upward trend has been fuelled by higher income countries...
January 14, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28081266/human-extravillous-trophoblasts-penetrate-decidual-veins-and-lymphatics-before-remodeling-spiral-arteries-during-early-pregnancy
#6
Nannan He, Liesbeth van Iperen, Danielle de Jong, Karoly Szuhai, Frans M Helmerhorst, Lucette A J van der Westerlaken, Susana M Chuva de Sousa Lopes
In humans, the defective invasion of the maternal endometrium by fetal extravillous trophoblasts (EVTs) can lead to insufficient perfusion of the placenta, resulting in pregnancy complications that can put both mother and baby at risk. To study the invasion of maternal endometrium between (W)5.5-12 weeks of gestation by EVTs, we combined fluorescence in situ hybridization, immunofluorescence and immunohistochemistry to determine the presence of (male) EVTs in the vasculature of the maternal decidua. We observed that interstitial mononuclear EVTs directly entered decidual veins and lymphatics from W5...
2017: PloS One
https://www.readbyqxmd.com/read/28076590/effect-of-maternal-exercises-on-biophysical-fetal-and-maternal-parameters-a-transversal-study
#7
Caroline Mombaque Dos Santos, Wendel Mombaque Dos Santos, Francisco Maximiliano Pancich Gallarreta, Camila Pigatto, Luiz Osório Cruz Portela, Edson Nunes de Morais
Objective: To evaluate the acute effects of maternal and fetal hemodynamic responses in pregnant women submitted to fetal Doppler and an aerobic physical exercise test according to the degree of effort during the activity and the impact on the well-being. Methods: Transversal study with low risk pregnant women, obtained by convenience sample with gestational age between 26 to 34 weeks. The participants carry out a progressive exercise test. Results: After the exercise session, reduced resistance (p=0...
October 2016: Einstein
https://www.readbyqxmd.com/read/28046002/competition-for-materno-fetal-resource-partitioning-in-a-rabbit-model-of-undernourished-pregnancy
#8
Jorge Lopez-Tello, Maria Arias-Alvarez, Maria Angeles Jimenez-Martinez, Rosa Maria Garcia-Garcia, Maria Rodriguez, Pedro Luis Lorenzo Gonzalez, Ruben Bermejo-Poza, Antonio Gonzalez-Bulnes, Pilar Garcia Rebollar
The major goal of animal production is to obtain abundant and healthy meat for consumers. Maternal food restriction (MFR) is often applied in farms to reduce production costs. However, the suitability of MFR in livestock animals is questionable, as this management may compromise maternal fitness due to a severe negative energetic balance and can induce Intrauterine Growth Restriction (IUGR) and prenatal programming in the offspring. Here, we sought to determine, using pregnant rabbits, the consequences of MFR on maternal endocrine and metabolic status and conceptus development...
2017: PloS One
https://www.readbyqxmd.com/read/28012457/identification-of-novel-genetic-markers-for-mouse-yolk-sac-cells-by-using-microarray-analyses
#9
Shinomi Yagi, Nobuyoshi Shiojiri
The mouse embryonic yolk sac consists of a visceral yolk sac (VYS) and parietal yolk sac (PYS), and may function as a materno-fetal exchange system for nutrients and wastes, and physical protector for the embryo/fetus. The present study was undertaken to characterize gene expression of the VYS and PYS endodermal cells, and to identify their novel genetic markers from microarray data. Apoa4, Lrp2, Fxyd2, Slc34a3 and Entpd2 were predominantly expressed in VYS epithelial cells. Gkn2 and Pga5 were selected as markers for PYS cells...
January 2017: Placenta
https://www.readbyqxmd.com/read/27898024/perinatal-arterial-ischemic-stroke-is-associated-to-materno-fetal-immune-activation-and-intracranial-arteritis
#10
Clémence Guiraut, Nicole Cauchon, Martin Lepage, Guillaume Sébire
The medium-size intra-cranial arteries arising from the carotid bifurcation are prone to perinatal arterial ischemic strokes (PAIS). PAIS' physiopathology needs to be better understood to develop preventive and therapeutic interventions that are currently missing. We hypothesized that materno-fetal inflammation leads to a vasculitis affecting selectively the carotidian tree and promoting a focal thrombosis and subsequent stroke. Dams were injected with saline or lipopolysaccharide (LPS) from Escherichia coli...
November 25, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27852037/placental-immune-editing-switch-pies-learning-about-immunomodulatory-pathways-from-a-unique-case-report
#11
Miguel H Bronchud, Francesc Tresserra, Wenjie Xu, Sarah Warren, Maite Cusido, Bernat Zantop, Ana Claudia Zenclussen, Alessandra Cesano
The hypothesis of this work is that, in order to escape the natural immune surveillance mechanisms, cancer cells and the surrounding microenvironment might express ectopically genes that are physiologically present in the placenta to mediate fetal immune-tolerance. These natural "placental immune-editing switch" mechanisms (PIES) may represent the result of millions of years of mammalian evolution developed to allow materno-fetal tolerance. Here, we introduce genes of the immune regulatory pathways that are either similarly over- or under-expressed in tumor vs normal tissue...
November 11, 2016: Oncotarget
https://www.readbyqxmd.com/read/27793493/-bacterial-vaginosis-and-spontaneous-preterm-birth
#12
G Brabant
OBJECTIVE: To determine if bacterial vaginosis is a marker for risk of spontaneous preterm delivery and if its detection and treatment can reduce this risk. METHODS: Consultation of the database Pubmed/Medline, Science Direct, and international guidelines of medical societies. RESULTS: Bacterial vaginosis (BV) is a dysbiosis resulting in an imbalance in the vaginal flora through the multiplication of anaerobic bacteria and jointly of a disappearance of well-known protective Lactobacilli...
December 2016: Journal de Gynécologie, Obstétrique et Biologie de la Reproduction
https://www.readbyqxmd.com/read/27732785/noninvasive-prenatal-dna-testing-the-vanguard-of-genomic-medicine
#13
Lisa Hui, Diana W Bianchi
Noninvasive prenatal DNA testing is the vanguard of genomic medicine. In only four years, this screening test has revolutionized prenatal care globally and opened up new prospects for personalized medicine for the fetus. There are widespread implications for increasing the scope of human genetic variation that can be detected before birth, and for discovering more about maternofetal and placental biology. These include an urgent need to develop pretest education for all pregnant women and consistent post-test management recommendations for those with discordant test results...
January 14, 2017: Annual Review of Medicine
https://www.readbyqxmd.com/read/27625611/the-calcium-sensing-receptor-and-the-reproductive-system
#14
REVIEW
Isabella Ellinger
Active placental transport of maternal serum calcium (Ca(2+)) to the offspring is pivotal for proper development of the fetal skeleton as well as various organ systems. Moreover, extracellular Ca(2+) levels impact on distinct processes in mammalian reproduction. The calcium-sensing receptor (CaSR) translates changes in extracellular Ca(2+)-concentrations into cellular reactions. This review summarizes current knowledge on the expression of CaSR and its putative functions in reproductive organs. CaSR was detected in placental cells mediating materno-fetal Ca(2+)-transport such as the murine intraplacental yolk sac (IPYS) and the human syncytiotrophoblast...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27621448/maternal-and-fetal-genomes-interplay-through-phosphoinositol-3-kinase-pi3k-p110%C3%AE-signaling-to-modify-placental-resource-allocation
#15
Amanda N Sferruzzi-Perri, Jorge López-Tello, Abigail L Fowden, Miguel Constancia
Pregnancy success and life-long health depend on a cooperative interaction between the mother and the fetus in the allocation of resources. As the site of materno-fetal nutrient transfer, the placenta is central to this interplay; however, the relative importance of the maternal versus fetal genotypes in modifying the allocation of resources to the fetus is unknown. Using genetic inactivation of the growth and metabolism regulator, Pik3ca (encoding PIK3CA also known as p110α, α/+), we examined the interplay between the maternal genome and the fetal genome on placental phenotype in litters of mixed genotype generated through reciprocal crosses of WT and α/+ mice...
October 4, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27571855/-not-available
#16
Rosa María Martínez García
El embarazo representa un desafío desde el punto de vista nutricional, debido a que las necesidades de nutrientes están aumentadas y una alteración en su ingesta puede afectar la salud materno-fetal. Estados deficitarios en micronutrientes están relacionados con preeclampsia, retraso del crecimiento intrauterino, aborto y anomalías congénitas. Actualmente, la dieta de muchas madres gestantes es insuficiente en micronutrientes, siendo necesaria su suplementación. Se recomienda la suplementación con ácido fólico en dosis de 400 μg/día, y de 5 mg en embarazadas de riesgo, debiendo comenzar al menos 1 mes antes de la concepción y durante las primeras 12 semanas de gestación, y prolongarla durante todo el embarazo en madres con riesgo nutricional...
July 12, 2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/27555319/maternofetal-pharmacokinetics-and-fetal-lung-responses-in%C3%A2-chronically-catheterized-sheep-receiving-constant-low-dose-infusions-of-betamethasone-phosphate
#17
Matthew W Kemp, Masatoshi Saito, Haruo Usuda, Timothy J Molloy, Yuichiro Miura, Shinichi Sato, Shimpei Watanabe, Michael Clarke, Michael Fossler, Augusto Scmidt, Suhas G Kallapur, Boris W Kramer, John P Newnham, Alan H Jobe
BACKGROUND: Antenatal steroids are standard of care for cases of anticipated preterm labor to improve neonatal outcomes. However, steroids are potent drugs, and their use in pregnancy remains largely unoptimized. OBJECTIVE: The objective of the study was to measure the maternofetal pharmacokinetics of constant, low-dose intravenous betamethasone phosphate infusions and correlate these data with the transcriptional effect exerted by subclinical betamethasone exposures on the ovine fetal lung...
December 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27298525/materno-fetal-outcomes-with-viral-hepatitis-in-pregnancy
#18
Anshuja Singla, Sumita Mehta, Shalini Rajaram, Sneha Shree
OBJECTIVE: To evaluate materno-fetal outcomes in pregnant women with jaundice. METHODS: A prospective study was conducted over a period of 6 months in a tertiary care hospital of Delhi, India. 82 pregnant women with jaundice were included. The serum was screened for viral markers, liver function tests, and coagulation status. RESULTS: The mean age of women was 27.3 ± 4.3 years. 43.9 % (n = 36) women were HEV positive, 36 % (n = 27) HBsAg positive, 4 % (n = 3) HAV positive and 1...
June 2016: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/27292274/a-physiological-increase-in-maternal-cortisol-alters-uteroplacental-metabolism-in-the-pregnant-ewe
#19
O R Vaughan, K L Davies, J W Ward, M J de Blasio, A L Fowden
Fetal nutrition is determined by maternal availability, placental transport and uteroplacental metabolism of carbohydrates. Cortisol affects maternal and fetal metabolism but whether maternal cortisol concentrations within the physiological range regulate uteroplacental carbohydrate metabolism remains unknown. This study determined the effect of maternal cortisol infusion (1.2 mg kg(-1)  day(-1) iv. for 5 days, n = 20) on fetal glucose, lactate and oxygen supplies in pregnant ewes on day ∼130 of pregnancy (term = 145 days)...
June 13, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/27155775/placentation-in-different-mammalian-species
#20
REVIEW
Pascale Chavatte-Palmer, Anne Tarrade
The placenta is a complex, transient organ associated with viviparity, which is located at the interface of the dam and fetus during pregnancy. It is formed after attachment, or implantation, of the blastocyst on the uterine lining and derives from complex cellular and molecular interactions between uterine and embryonic tissues. In mammals, there are many forms of placentation but this organ has the same function in all species: it is responsible for orchestrating materno-fetal exchanges, together with endocrine and immunological functions...
June 2016: Annales D'endocrinologie
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