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Plexus choroideus

Manuel Menéndez-González, Alfonso López-Muñiz, José A Vega, José M Salas-Pacheco, Oscar Arias-Carrión
BACKGROUND AND PURPOSE: Despite a strong correlation to severity of AD pathology, the measurement of medial temporal lobe atrophy (MTA) is not being widely used in daily clinical practice as a criterion in the diagnosis of prodromal and probable AD. This is mainly because the methods available to date are sophisticated and difficult to implement for routine use in most hospitals-volumetric methods-or lack objectivity-visual rating scales. In this pilot study we aim to describe a new, simple and objective method for measuring the rate of MTA in relation to the global atrophy using clinically available neuroimaging and describe the rationale behind this method...
2014: Frontiers in Aging Neuroscience
Nurdan Tacyildiz, Derya Ozyörük, Gülsan Yavuz, Emel Cabı Unal, Handan Dinçaslan, Gülşah Oktay Tanyıldız, Zülfikar Gördü, Zeynep Sıklar, Merih Berberoğlu, Gönül Ocal
BACKGROUND: It has been estimated that rare tumor rate is about 15% of all childhood cancer in United States. According to Turkish Pediatric Oncology Group (TPOG) datas, 8889 children were diagnosed between 2002 and 2008 in our country and 3.7% of them were diagnosed as rare tumors. AIM: To investigate the frequency and clinical features of rare tumors in our pediatric oncology center. MATERIALS AND METHODS: A total of 43 cases that have diagnosed as rare tumor in 574 cancer patients between the yaer 2002 and 2012 were reviewed retrospectively...
October 2013: Indian Journal of Medical and Paediatric Oncology
Péter Hauser, Ildikó Vancsó, Tímea Pócza, Dezső Schuler, Miklós Garami
In Hungary a new oral antiangiogenic treatment was introduced in cases of primary chemoresistant or recurrent pediatric CNS tumors, called Kieran schedule. The early results of this treatment were analyzed. From 2010 at Semmelweis University on individual decisions a daily combined per oral treatment was introduced in pediatric patients with recurrent or progressive CNS tumor (Kieran schedule: thalidomid, celecoxib, etoposid and cyclophosphamid). Efficacy of therapy was analyzed in terms of demographic data, histology, side effects and tolerability in a retrospective manner...
December 2013: Magyar Onkologia
K Jäger, S Wolf, H Dobrowolny, J Steiner, H Nave, E Maronde, B Bogerts, H-G Bernstein
The cellular uptake of L-arginine and other cationic amino acids (such as L-lysine and L-ornithine) is mainly mediated by cationic amino acid transporter (CAT) proteins. Despite the important roles of cationic amino acid transporters for normal brain functioning and various brain diseases there is currently only fragmentary knowledge about their cellular and regional distribution patterns in the human brain. We mapped the immunohistochemical localization of human cationic amino acid transporters 1, 2 and 3 (hCAT1, 2, and 3) throughout five adult human brains and found a wide but uneven distribution of these transporters...
February 2013: Amino Acids
Mira Schroten, Franz-Georg Hanisch, Natascha Quednau, Carolin Stump, Roland Riebe, Matthias Lenk, Hartwig Wolburg, Tobias Tenenbaum, Christian Schwerk
Epithelial cells of the plexus choroideus form the structural basis of the blood-cerebrospinal fluid barrier (BCSFB). In vitro models of the BCSFB presenting characteristics of a functional barrier are of significant scientific interest as tools for examination of BCSFB function. Due to a lack of suitable cell lines as in vitro models, primary porcine plexus epithelial cells were subjected to a series of selective cultivation steps until a stable continuous subcultivatable epithelial cell line (PCP-R) was established...
2012: PloS One
Nicole Eberhard, Christian Mayer, Radmila Santic, Ruben Peco Navio, Andrea Wagner, Hans Christian Bauer, Guenther Sperk, Ulrich Boehm, Barbara Kofler
Alarin is a 25 amino acid peptide that belongs to the galanin peptide family. It is derived from the galanin-like peptide gene by a splice variant, which excludes exon 3. Alarin was first identified in gangliocytes of neuroblastic tumors and later shown to have a vasoactive function in the skin. Recently, alarin was demonstrated to stimulate food intake as well as the hypothalamic-pituitary-gonadal axis in rodents, suggesting that it might be a neuromodulatory peptide in the brain. However, the individual neurons in the central nervous system that express alarin have not been identified...
January 2012: Journal of Molecular Neuroscience: MN
I González-Marrero, E M Carmona-Calero, P Fernández-Rodríguez, H Pérez-González, C Ormazabal-Ramos, L Castañeyra-Ruiz, C G Pérez-García, I Martínez-Peña-Valenzuela, A Castañeyra-Ruiz, A Castañeyra-Perdomo, R Ferres-Torres
The objective of this study was to analyze the proteins in the cerebrospinal fluid of spontaneously hypertensive rats and to study their possible role in the relationship between hydrocephalus, arterial hypertension and variations in the subfornical organ. Brains and cerebrospinal fluid from control Wistar-Kyoto rats and spontaneously hypertensive rats sacrificed with chloral hydrate were used. Cerebrospinal fluid and extract of subfornical organ were processed by protein electrophoresis. Antisera against protein bands of 141, 117 and 48 kDa and Concanavalin A were used for immunohistochemical and western blot study of the subfornical organ, adjacent circumventricular structures and cerebrospinal fluid...
2007: Histology and Histopathology
Karin Kosulin, Christine Haberler, Johannes A Hainfellner, Gabriele Amann, Susanna Lang, Thomas Lion
Adenoviruses (AdVs) contain genes coding for proteins with transforming potential, and certain AdV serotypes have been shown to induce tumors in rodents. However, data on the possible oncogenicity of AdVs in humans are scarce. We have therefore employed a real-time quantitative PCR (RQ-PCR) assay permitting highly sensitive detection of all 51 currently known human AdV serotypes to screen more than 500 tumor specimens derived from 17 different childhood cancer entities including leukemias, lymphomas, and solid tumors...
July 2007: Journal of Virology
A Hidalgo-Carballal, M P Suárez-Mier
A 4-year-old child with chickenpox infection for 5 days prior to death complained of swelling and pain in his right leg that required medical assistance in the emergency department. Radiologic study was normal, and analgesic and bandage of the leg were prescribed. Some hours later, he presented cyanosis, dizziness, and vomiting and collapsed. A complete forensic autopsy was performed 12 hours after death. External examination of the body showed numerous crusty varicella skin lesions, especially over the trunk, and swelling and reddening of his right leg...
March 2006: American Journal of Forensic Medicine and Pathology
Hakim Echchannaoui, Philipp Bachmann, Maryse Letiembre, Manuel Espinosa, Regine Landmann
The phagocyte pattern recognition receptor Toll-like receptor 2 (TLR2) and the multi-receptor adaptor MyD88 contribute to the reduction of bacterial load in infections with intra- and extra-cellular Gram-positive bacteria. Their mechanism of antibacterial action is mostly unresolved but evident in vivo by an increased pathogen burden in infected TLR2-/- and MyD88-/- compared to C57BL/6 wild type (wt) mice. We had previously observed higher bacterial numbers in brains of TLR2-/- than of wt mice with meningitis...
2005: Immunobiology
Birgitte Stoevring, Irakli Jaliashvili, Annemette V Thougaard, Christian Ensinger, Claus K Høgdall, Lars S Rasmussen, Finn Sellebjerg, Michael Christiansen
BACKGROUND: Tetranectin (TN) is a 67 kDa glycoprotein thought to play a prominent role in the regulation of proteolytic processes via its binding to plasminogen and indirect activation of plasminogen. The TN concentration in serum is approximately 10 mg/l and is reduced in patients with several cancers. The TN concentration in the normal CSF has not been examined. METHODS: The TN concentration in the serum and CSF of 47 normal subjects without neurological disorders was established using a polyclonal sandwich ELISA...
September 2005: Clinica Chimica Acta; International Journal of Clinical Chemistry
Jan M Schwab, Sabine Conrad, Philippe P Monnier, Sylvie Julien, Bernhard K Mueller, Hermann J Schluesener
The repulsive guidance molecule (RGM) is involved in the formation of the central nervous system (CNS) during development by modulating guidance of growing axons. However, a role of RGM in CNS injury remains to be established. We studied the expression of RGM in the spinal cord of rats with spinal cord injury (SCI). After SCI, RGM+ cells accumulated in lesions and peri-lesional areas. During the first days after SCI, RGM expression was confined to neurons, ballooned neurite fibers/retraction bulbs, smooth muscle/endothelial cells, and to leucocytes infiltrating the lesion...
March 2005: European Journal of Neuroscience
Selma Alicelebić, Zakira Mornjaković, Zlata Kundurović
BACKGROUND AND PURPOSE: Developmental process that leads to final forebrain shaping is a result of complex histogenetic and morphogenetic events. Comprehensions about brain development are based on observations carried out on onthogenetic successive stages. Microscopic analysis of brain together with analysis of serial sections gives information about shape the of some forebrain parts and basic relations between them. The aim of this study was to analyse morphogenesis in the earliest stages of rat's forebrain development...
February 2004: Bosnian Journal of Basic Medical Sciences
Neriman Colakoğlu, Aysel Kükner
Vitamin A metabolites are potent teratogens in a wide variety of species, including man. Transforming growth factor betas (TGF-betas) are involved in several mammalian prenatal developmental processes. The aim of this study was to determine the effects of exogenous and excessive all-trans retinoic acid on TGFbeta2 expression in the developing cerebral cortex of the rat. Many of the malformations including exencephaly, exophtalmus, abdominal wall defects, extremity reduction defects observed in this study were dependent on the time of administration of retinoic acid...
November 2004: Journal of Molecular Histology
David A Groneberg, Isabel Rubio-Aliaga, Monika Nickolaus, Frank Döring, Axel Fischer, Hannelore Daniel
Carrier-mediated transport of small peptides and peptidomimetics offers the opportunity for a targeted drug delivery across cell membranes in the central nervous system (CNS). This process is mediated by the proton-coupled transporter PEPT2 which is expressed in glial and choroid plexus cells. In the present studies, an uptake assay was established to visualize directly peptide uptake in intact rat brain slices. Accumulation of a reporter molecule, the fluorophore-labeled dipeptide derivative D-Ala-L-Lys-AMCA, was found in plexus choroideus and glial cells and uptake was inhibited by prototypical PEPT2 substrates, such as glycyl-L-glutamine and cefadroxil...
June 24, 2004: Neuroscience Letters
No abstract text is available yet for this article.
November 30, 1959: Zentralblatt Für Allgemeine Pathologie und Pathologische Anatomie
H Q Niu, K Eckhardt, C B Ostertag
The standard surgical treatment of hydrocephalus by cerebrospinal fluid (CSF) shunt is accompanied by numerous complications. The search for alternative treatment methods includes resection, coagulation and irradiation of part of the plexus choroideus. The reduction of CSF secretion after choroid plexus (CP) irradiation has been investigated only on the experimental level. The new Photon Radiosurgery System (PRS) now also provides clinically the opportunity to induce selective radionecrosis on the CP with high efficiency and safety...
April 2003: Minimally Invasive Neurosurgery: MIN
A D Gruber, A Wessmann, M Vandevelde, B A Summers, A Tipold
A 10-month-old female Parson Jack Russell Terrier was euthanatized because of therapy-resistant ataxia, hypermetria, and deafness that had first been observed at 10 weeks of age. Severe, bilateral, symmetrical neuronal degeneration and mineralization of the brain were found in the cochlear and cerebellar nuclei, dorsal areas of the medulla oblongata, the vestibulocochlear nerve, plexus choroideus, and within the granule cell layer of the ventral cerebellar hemispheres. The mineralized deposits were located free in the parenchyma, around intact or degenerate neurons, in myocytes of small- and medium-sized arteries, and around capillaries...
November 2002: Veterinary Pathology
Frank P M Kruijver, Rawien Balesar, Ana M Espila, Unga A Unmehopa, Dick F Swaab
The present study reports the first systematic rostrocaudal distribution of estrogen receptor-alpha immunoreactivity (ERalpha-ir) in the human hypothalamus and its adjacent areas in young adults. Postmortem material taken from 10 subjects (five male and five female), between 20 and 39 years of age, was investigated. In addition, three age-matched subjects with abnormal levels of estrogens were studied: a castrated, estrogen-treated 50-year-old male-to-female transsexual (T1), a 31-year-old man with an estrogen-producing tumor (S2), and an ovariectomized 46-year-old woman (S8)...
December 9, 2002: Journal of Comparative Neurology
A Schmitt, E Asan, K-P Lesch, Peter Kugler
Rapid uptake of synaptically released glutamate via the high affinity glutamate transporter 1 (GLT1; EAAT2) is important for limiting transmitter signalling and prevents a harmful receptor overstimulation. So far, in the adult brain GLT1 protein has only been detected in astrocytes. Here, we describe the cDNA cloning of a variant of GLT1 from rat brain which is generated by alternative splicing at the 3'-end of the GLT1 cDNA. Reverse transcription-polymerase chain reaction revealed that the GLT1 variant message was present not only in brain, but also in peripheral organs...
2002: Neuroscience
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