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Choroid plexus

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https://www.readbyqxmd.com/read/29148023/fluid-structure-interaction-model-analysis-of-cerebrospinal-fluid-circulation-in-patients-with-continuous-flow-left-ventricular-assist-devices
#1
Jessica G Y Luc, Clifford A Pierre, Kevin Phan, Yashar S Vahedein, Alexander S Liberson, William K Cornwell, Steven J Phillips, Vakhtang Tchantchaleishvili
PURPOSE: The current 1-dimensional fluid structure interaction model (FSI) for understanding cerebrospinal fluid (CSF) circulation requires pulsatility as a precondition and has not been applied to patients with continuous-flow left ventricular assist devices (CF-LVAD) where pulsatility is chronically reduced. Our study aims to characterize the behavior of CSF pressure and flow in patients with CF-LVADs using a computational FSI model. METHODS: Utilizing the computational FSI model, CSF production in choroid plexuses of the 4 ventricles was specified as a boundary condition for the model...
November 16, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/29142154/the-choroid-plexus-of-the-lateral-ventricle-as-the-origin-of-csf-pulsation-is-questionable
#2
Ken Takizawa, Mitsunori Matsumae, Naokazu Hayashi, Akihiro Hirayama, Fumiya Sano, Satoshi Yatsushiro, Kagayaki Kuroda
The advent of magnetic resonance imaging (MRI) enables noninvasive measurement of cerebrospinal fluid (CSF) motion, and new information about CSF motion has now been acquired. The driving force of the CSF has long been thought to be choroid plexus (CP) pulsation, but to investigate whether this phenomenon actually occurs, CSF motion was observed in the ventricular system and subarachnoid space using MRI. Eleven healthy volunteers, ranging in age from 23 to 58 years, participated in this study. The MRI sequences used were four-dimensional phase-contrast (4D-PC) and time-spatial labeling inversion pulse (t-SLIP)...
November 16, 2017: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/29142152/indirect-proton-mr-imaging-and-kinetic-analysis-of-17-o-labeled-water-tracer-in-the-brain
#3
Kohsuke Kudo, Taisuke Harada, Hiroyuki Kameda, Ikuko Uwano, Fumio Yamashita, Satomi Higuchi, Kunihiro Yoshioka, Makoto Sasaki
PURPOSE: The feasibility of steady-state sequences for (17)O imaging was evaluated based on a kinetic analysis of the brain parenchyma and cerebrospinal fluid (CSF). MATERIALS AND METHODS: The institutional review board approved this prospective study with written informed consent. Dynamic 2D or 3D steady-state sequences were performed in five and nine participants, respectively, with different parameters using a 3T scanner. During two consecutive dynamic scans, saline was intravenously administered for control purposes in the first scan, and 20% (17)O-labeled water (1 mL/Kg) was administered in the second scan...
November 16, 2017: Magnetic Resonance in Medical Sciences: MRMS
https://www.readbyqxmd.com/read/29125515/endoscopic-third-ventriculostomy-to-address-hydrocephalus-in-africa-a-call-for-education-and-community-based-rehabilitation
#4
Andres Jimenez-Gomez, Heidi Castillo, Caryssa Burckart, Jonathan Castillo
PURPOSE: Endoscopic Third Ventriculostomy (ETV) and Choroid Plexus Cautery (CPC) are low-cost, safe, and promising interventions for spina bifida-associated hydrocephalus (SBHCP). The purpose of this review was to explore and describe these efforts in Africa in order to upscale surgical training and rehabilitation services. METHODS: A PubMed search for articles on ETV and CPC as management of SBHCP in Africa was performed. Two authors appraised the results for key themes in content: indications, technique, outcomes, complications, education, and rehabilitation...
October 27, 2017: Journal of Pediatric Rehabilitation Medicine
https://www.readbyqxmd.com/read/29125447/multiple-echocardiography-abnormalities-associated-with-endoscopic-third-ventriculostomy-failure
#5
Ashish H Shah, George M Ibrahim, Jun Sasaki, John Ragheb, Sanjiv Bhatia, Toba N Niazi
OBJECTIVE Although endoscopic third ventriculostomy (ETV) with choroid plexus cauterization (CPC) has gained increasing prominence in the management of hydrocephalus caused by intraventricular hemorrhage of prematurity, the rates of long-term shunt independence remain low. Furthermore, limited evidence is available to identify infants who might benefit from the procedure. The authors tested the hypothesis that elevated venous pressure that results from comorbid cardiac disease might predispose patients to ETV/CPC failure and shunt dependence...
November 10, 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29125413/a-computational-fluid-dynamics-simulation-framework-for-ventricular-catheter-design-optimization
#6
Sofy H Weisenberg, Stephanie C TerMaath, Charlotte N Barbier, Judith C Hill, James A Killeffer
OBJECTIVE Cerebrospinal fluid (CSF) shunts are the primary treatment for patients suffering from hydrocephalus. While proven effective in symptom relief, these shunt systems are plagued by high failure rates and often require repeated revision surgeries to replace malfunctioning components. One of the leading causes of CSF shunt failure is obstruction of the ventricular catheter by aggregations of cells, proteins, blood clots, or fronds of choroid plexus that occlude the catheter's small inlet holes or even the full internal catheter lumen...
November 10, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29125025/choroid-plexus-avm-with-anomalous-origin-of-the-capsulothalamic-artery-a-case-report
#7
Shigeru Yamauchi, Taichiro Kawakami, Keiji Murata, Tomoya Ishiguro, Hidetoshi Ikeda, Akimasa Nishio
Background and importance Traditionally, it has been believed that the plexal segment of the anterior choroidal artery (AChoA) can be sacrificed safely. Here, we present a case of choroid plexus arteriovenous malformation (AVM) in which the capsulothalamic artery originated from distal plexal segment of the AChoA. Clinical presentation A 45-year-old man was diagnosed with arteriovenous malformation involving the left inferior horn in screening MRI. Preceding stereotactic radiosurgery, transarterial target embolization was performed...
January 1, 2017: Interventional Neuroradiology
https://www.readbyqxmd.com/read/29124088/considerations-and-code-for-partial-volume-correcting-18-f-av-1451-tau-pet-data
#8
Suzanne L Baker, Anne Maass, William J Jagust
[(18)F]-AV-1451 is a leading tracer used with positron emission tomography (PET) to quantify tau pathology. However, [(18)F]-AV-1451 shows "off target" or non-specific binding, which we define as binding of the tracer in unexpected areas unlikely to harbor aggregated tau based on autopsy literature [1]. Along with caudate, putamen, pallidum and thalamus non-specific binding [2], [3], we have found binding in the superior portion of the cerebellar gray matter, leading us to use inferior cerebellar gray as the reference region...
December 2017: Data in Brief
https://www.readbyqxmd.com/read/29110779/dosing-collection-and-quality-control-issues-in-cerebrospinal-fluid-research-using-animal-models
#9
Donna M Barten, Gregory W Cadelina, Michael R Weed
Cerebrospinal fluid (CSF) is a complex fluid filling the ventricular system and surrounding the brain and spinal cord. Although the bulk of CSF is created by the choroid plexus, a significant fraction derives from the interstitial fluid in the brain and spinal cord parenchyma. For this reason, CSF can often be used as a source of pharmacodynamic and prognostic biomarkers to reflect biochemical changes occurring within the brain. For instance, CSF biomarkers can be used to diagnose and track progression of disease as well as understand pharmacokinetic and pharmacodynamic relationships in clinical trials...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/29110772/the-cerebrospinal-fluid-and-barriers-anatomic-and-physiologic-considerations
#10
Hayrettin Tumani, André Huss, Franziska Bachhuber
The cerebrospinal fluid (CSF) space consists of the intracerebral ventricles, subarachnoid spaces of the spine and brain (e.g., cisterns and sulci), and the central spinal cord canal. The CSF protects the central nervous system (CNS) in different ways involving metabolic homeostasis, supply of nutrients, functioning as lymphatic system, and regulation of intracranial pressure. CSF is produced by the choroid plexus, brain interstitium, and meninges, and it circulates in a craniocaudal direction from ventricles to spinal subarachnoid space from where it is removed via craniocaudal lymphatic routes and the venous system...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/29109897/optic-coherence-angiography-findings-in-type-2-macular-telangiectasia
#11
Hilal Nalcı, Figen Şermet, Sibel Demirel, Emin Özmert
Objectives: To evaluate the vascular changes of idiopathic macular telangiectasia type 2 (MacTel 2) patients with optical coherence tomography angiography (OCTA) and correlate these changes with the findings of spectral domain optical coherence tomography (SD-OCT). Materials and Methods: Simultaneous SD-OCT and OCTA images of 10 eyes of 6 patients who were diagnosed as MacTel 2 in Ankara University Faculty of Medicine, Department of Ophthalmology were obtained and graded according to the OCTA grading system for MacTel 2...
October 2017: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/29109132/granulocytic-sarcoma-of-the-choroid-plexus-complicating-acute-leukemia
#12
Caroline Apra, Pierre Bourdillon
No abstract text is available yet for this article.
November 7, 2017: Neurology
https://www.readbyqxmd.com/read/29100949/plasticity-of-the-human-visual-brain-after-early-cortical-lesion
#13
K Mikellidou, R Arrighi, G Aghakhanyan, F Tinelli, F Frijia, S Crespi, F De Masi, D Montanaro, M C Morrone
In adults, partial damage to V1 or optic radiations abolishes perception in the corresponding part of the visual field, causing a scotoma. However, it is widely accepted that the developing cortex has superior capacities to reorganize following an early lesion to endorse adaptive plasticity. Here we report a single patient case (G.S.) with near normal central field vision despite a massive unilateral lesion to the optic radiations acquired early in life. The patient underwent surgical removal of a right hemisphere parieto-temporal-occipital atypical choroid plexus papilloma of the right lateral ventricle at four months of age, which presumably altered the visual pathways during in utero development...
October 31, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/29088955/real-time-ultrasound-guided-external-ventricular-drain-placement-technical-note
#14
James H Manfield, Kenny K H Yu
In the United Kingdom, ultrasound-guided external ventricular drain (EVD) insertion is becoming the standard of care to mitigate the morbidity associated with catheter malposition and multiple passes. Many neurosurgeons routinely use ultrasound to check the preinsertion trajectory, although real-time visualization of ventricular cannulation is preferable since minor deviations can be significant in patients with smaller ventricles, and live visualization further enables the catheter tip to be adjusted away from the choroid plexus...
November 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/29077256/screening-with-whole-body-magnetic-resonance-imaging-in-pediatric-subjects-with-li-fraumeni-syndrome-a-single-institution-pilot-study
#15
Allison F O'Neill, Stephan D Voss, Jyothi P Jagannathan, Junne Kamihara, Callie Nibecker, Elena Itriago-Araujo, Serena Masciari, Erin Parker, Mauricio Barreto, Wendy B London, Judy E Garber, Lisa Diller
BACKGROUND: Li-Fraumeni syndrome (LFS) is an autosomal dominant hereditary cancer syndrome associated with germline mutations in the TP53 gene and a high risk of childhood-onset malignancies. Cancer surveillance is challenging in pediatric mutation carriers given the anatomic spectrum of malignancies and young age of onset. Whole-body magnetic resonance imaging (WB-MRI) may provide an acceptable method for early cancer detection. PROCEDURE: We conducted a prospective feasibility pilot study of pediatric subjects (age < 18 years) with LFS to determine return rates for annual WB-MRI scan...
October 27, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29076966/revisiting-tumor-patterns-and-penetrance-in-germline-tp53-mutation-carriers-temporal-phases-of-li-fraumeni-syndrome
#16
Amina Amadou, Maria I Waddington Achatz, Pierre Hainaut
PURPOSE OF REVIEW: Germline pathogenic TP53 mutation may predispose to multiple cancers but penetrance and cancer patterns remain incompletely documented. We have analyzed international agency for research on cancer TP53 database to reevaluate age and variant-dependent tumor patterns. RECENT FINDINGS: Genome-wide studies suggest that germline variants are more frequent than estimated prevalence of Li-Fraumeni syndrome (LFS), suggesting that many carriers of potentially pathogenic mutations may not develop the syndrome...
October 25, 2017: Current Opinion in Oncology
https://www.readbyqxmd.com/read/29076795/reliability-of-csf-turbulence-and-choroid-plexus-visualization-on-fast-sequence-mri-in-pediatric-hydrocephalus
#17
Curtis J Rozzelle, Casey Madura, Ron W Reeder
OBJECTIVE Endoscopic third ventriculostomy with choroid plexus cauterization for the treatment of neonatal and infant hydrocephalus has gained popularity in the past decade. Identifying treatment failure is critically important. Results of a pilot study of 2 novel imaging markers seen on fast-sequence T2-weighted axial MRI showed potential clinical utility. However, the reliability of multiple raters detecting these markers must be established before a multicenter validation study can be performed. METHODS Two sets of de-identified single-shot T2-weighted turbo spin-echo axial images were prepared from scans of patients before and after they underwent endoscopic third ventriculostomy with choroid plexus cauterization between March 2013 and January 2016...
October 27, 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29070607/contribution-of-de-novo-and-mosaic-tp53-mutations-to-li-fraumeni-syndrome
#18
Mariette Renaux-Petel, Françoise Charbonnier, Jean-Christophe Théry, Pierre Fermey, Gwendoline Lienard, Jacqueline Bou, Sophie Coutant, Myriam Vezain, Edwige Kasper, Steeve Fourneaux, Sandrine Manase, Maud Blanluet, Bruno Leheup, Ludovic Mansuy, Jacqueline Champigneulle, Céline Chappé, Michel Longy, Nicolas Sévenet, Brigitte Bressac-de Paillerets, Léa Guerrini-Rousseau, Laurence Brugières, Olivier Caron, Jean-Christophe Sabourin, Isabelle Tournier, Stéphanie Baert-Desurmont, Thierry Frébourg, Gaëlle Bougeard
BACKGROUND: Development of tumours such as adrenocortical carcinomas (ACC), choroid plexus tumours (CPT) or female breast cancers before age 31 or multiple primary cancers belonging to the Li-Fraumeni (LFS) spectrum is, independently of the familial history, highly suggestive of a germline TP53 mutation. The aim of this study was to determine the contribution of de novo and mosaic mutations to LFS. METHODS AND RESULTS: Among 328 unrelated patients harbouring a germline TP53 mutation identified by Sanger sequencing and/or QMPSF, we could show that the mutations had occurred de novo in 40 cases, without detectable parental age effect...
October 25, 2017: Journal of Medical Genetics
https://www.readbyqxmd.com/read/29070490/the-diverse-cellular-responses-of-the-choroid-plexus-during-infection-of-the-central-nervous-system
#19
Alexa N Lauer, Tobias Tenenbaum, Horst Schroten, Christian Schwerk
The choroid plexus (CP) is responsible for the production of a large amount of the cerebrospinal fluid (CSF). As a highly vascularized structure, the CP also presents a significant frontier between the blood and the central nervous system (CNS). To seal this border, the epithelium of the CP forms the blood-CSF barrier (BCSFB), one of the most important barriers separating the CNS from the blood. During the course of infectious disease, cells of the CP can experience interactions with intruding pathogens, especially when the CP is used as gateway for entry into the CNS...
October 25, 2017: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/29053774/plasma-klotho-and-frailty-in-older-adults-findings-from-the-inchianti-study
#20
Michelle Shardell, Richard D Semba, Rita R Kalyani, Stefania Bandinelli, Aric A Prather, Chee W Chia, Luigi Ferrucci
Background: The hormone klotho, encoded by the gene klotho, is primarily expressed in the kidney and choroid plexus of the brain. Higher klotho concentrations have been linked to better physical performance; however, it is unknown whether klotho relates to frailty status in older adults. Methods: Plasma klotho was measured in 774 participants aged ≥ 65 years enrolled in InCHIANTI, a prospective cohort study comprising Italian adults. Frailty status was assessed at three and six years after enrollment...
October 19, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
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