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https://www.readbyqxmd.com/read/27729841/in-silico-study-of-mirna-based-gene-regulation-involved-in-solid-cancer-by-the-assistance-of-argonaute-protein
#1
Surya Narayan Rath, Debasrita Das, V Badireenath Konkimalla, Sukanta Kumar Pradhan
Solid tumor is generally observed in tissues of epithelial or endothelial cells of lung, breast, prostate, pancreases, colorectal, stomach, and bladder, where several genes transcription is regulated by the microRNAs (miRNAs). Argonaute (AGO) protein is a family of protein which assists in miRNAs to bind with mRNAs of the target genes. Hence, study of the binding mechanism between AGO protein and miRNAs, and also with miRNAs-mRNAs duplex is crucial for understanding the RNA silencing mechanism. In the current work, 64 genes and 23 miRNAs have been selected from literatures, whose deregulation is well established in seven types of solid cancer like lung, breast, prostate, pancreases, colorectal, stomach, and bladder cancer...
September 2016: Genomics & Informatics
https://www.readbyqxmd.com/read/27363020/globally-increased-ultraconserved-noncoding-rna-expression-in-pancreatic-adenocarcinoma
#2
Jinmai Jiang, Ana Clara P Azevedo-Pouly, Roxana S Redis, Eun Joo Lee, Yuriy Gusev, David Allard, Dhruvitkumar S Sutaria, Mohamed Badawi, Ola A Elgamal, Megan R Lerner, Daniel J Brackett, George A Calin, Thomas D Schmittgen
Transcribed ultraconserved regions (T-UCRs) are a class of non-coding RNAs with 100% sequence conservation among human, rat and mouse genomes. T-UCRs are differentially expressed in several cancers, however their expression in pancreatic adenocarcinoma (PDAC) has not been studied. We used a qPCR array to profile all 481 T-UCRs in pancreatic cancer specimens, pancreatic cancer cell lines, during experimental pancreatic desmoplasia and in the pancreases of P48Cre/wt; KrasLSL-G12D/wt mice. Fourteen, 57 and 29% of the detectable T-UCRs were differentially expressed in the cell lines, human tumors and transgenic mouse pancreases, respectively...
June 23, 2016: Oncotarget
https://www.readbyqxmd.com/read/27224231/apparent-diffusion-coefficient-and-dynamic-contrast-enhanced-magnetic-resonance-imaging-in-pancreatic-cancer-characteristics-and-correlation-with-histopathologic-parameters
#3
Wanling Ma, Na Li, Weiwei Zhao, Jing Ren, Mengqi Wei, Yong Yang, Yingmei Wang, Xin Fu, Zhuoli Zhang, Andrew C Larson, Yi Huan
OBJECTIVE: To clarify diffusion and perfusion abnormalities and evaluate correlation between apparent diffusion coefficient (ADC), MR perfusion and histopathologic parameters of pancreatic cancer (PC). METHODS: Eighteen patients with PC underwent diffusion-weighted imaging and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). Parameters of DCE-MRI and ADC of cancer and non-cancerous tissue were compared. Correlation between the rate constant that represents transfer of contrast agent from the arterial blood into the extravascular extracellular space (K, volume of the extravascular extracellular space per unit volume of tissue (Ve), and ADC of PC and histopathologic parameters were analyzed...
September 2016: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/27108064/calcium-sensing-receptor-suppresses-human-pancreatic-tumorigenesis-through-a-novel-ncx1-ca-2-%C3%AE-catenin-signaling-pathway
#4
Bo Tang, Jimmy Y C Chow, Tobias Xiao Dong, Shi-Ming Yang, De-Sheng Lu, John M Carethers, Hui Dong
The calcium sensing receptor (CaSR) is functionally expressed in normal human pancreases, but its pathological role in pancreatic tumorigenesis is currently unknown. We sought to investigate the role of CaSR in pancreatic cancer (PC) and the underlying molecular mechanisms. We revealed that the expression of CaSR was consistently downregulated in the primary cancer tissues from PC patients, which was correlated with tumor size, differentiation and poor survival of the patients. CaSR activation markedly suppressed pancreatic tumorigenesis in vitro and in vivo likely through the Ca(2+) entry mode of Na(+)/Ca(2+) exchanger 1 (NCX1) to induce Ca(2+) entry into PC cells...
July 10, 2016: Cancer Letters
https://www.readbyqxmd.com/read/27070277/effects-of-obesity-and-diabetes-on-%C3%AE-and-%C3%AE-cell-mass-in-surgically-resected-human-pancreas
#5
Jun Inaishi, Yoshifumi Saisho, Seiji Sato, Kinsei Kou, Rie Murakami, Yuusuke Watanabe, Minoru Kitago, Yuko Kitagawa, Taketo Yamada, Hiroshi Itoh
CONTEXT: The ethnic difference in β-cell regenerative capacity in response to obesity may be attributable to different phenotypes of type 2 diabetes among ethnicities. OBJECTIVE: This study aimed to clarify the effects of diabetes and obesity on β- (BCM) and α-cell mass (ACM) in the Japanese population. DESIGN, SETTING, AND PARTICIPANTS: We obtained the pancreases of 99 individuals who underwent pancreatic surgery and whose resected pancreas sample contained adequate normal pancreas for histological analysis...
July 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/26842750/using-quantitative-seroproteomics-to-identify-antibody-biomarkers-in-pancreatic-cancer
#6
Darshil T Jhaveri, Min-Sik Kim, Elizabeth D Thompson, Lanqing Huang, Rajni Sharma, Alison P Klein, Lei Zheng, Dung T Le, Daniel A Laheru, Akhilesh Pandey, Elizabeth M Jaffee, Robert A Anders
Pancreatic cancer is the fourth leading cause of cancer-related deaths in the United States. Less than 6% of patients survive beyond the fifth year due to inadequate early diagnostics and ineffective treatment options. Our laboratory has developed an allogeneic, granulocyte-macrophage colony-stimulating factor (GM-CSF)-secreting pancreatic cancer vaccine (GVAX) that has been tested in phase II clinical trials. Here, we employed a serum antibodies-based SILAC immunoprecipitation (SASI) approach to identify proteins that elicit an antibody response after vaccination...
March 2016: Cancer Immunology Research
https://www.readbyqxmd.com/read/26415128/harmonic-motion-imaging-for-abdominal-tumor-detection-and-high-intensity-focused-ultrasound-ablation-monitoring-an-in-vivo-feasibility-study-in-a-transgenic-mouse-model-of-pancreatic-cancer
#7
Hong Chen, Gary Y Hou, Yang Han, Thomas Payen, Carmine F Palermo, Kenneth P Olive, Elisa E Konofagou
Harmonic motion imaging (HMI) is a radiationforce- based elasticity imaging technique that tracks oscillatory tissue displacements induced by sinusoidal ultrasonic radiation force to assess the resulting oscillatory displacement denoting the underlying tissue stiffness. The objective of this study was to evaluate the feasibility of HMI in pancreatic tumor detection and high-intensity focused ultrasound (HIFU) treatment monitoring. The HMI system consisted of a focused ultrasound transducer, which generated sinusoidal radiation force to induce oscillatory tissue motion at 50 Hz, and a diagnostic ultrasound transducer, which detected the axial tissue displacements based on acquired radio-frequency signals using a 1-D cross-correlation algorithm...
September 2015: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/26192788/risk-of-additional-pancreatic-cancer-in-patients-with-branch-duct-intraductal-papillary-mucinous-neoplasm
#8
Satoshi Tanno, Takeshi Obara, Kazuya Koizumi, Yasuhiro Nakano, Manabu Osanai, Yusuke Mizukami, Yutaka Kohgo
Branch duct intraductal papillary-mucinous neoplasms of the pancreas (BD-IPMN) are being diagnosed with increasing frequency. Although BD-IPMN outcomes are generally good, pancreatic ductal adenocarcinoma (PDA) is found distant from the original BD-IPMN in about 3.3-9.2% of cases. These reports raise the question of whether a possible association exists between BD-IPMN and PDA. Recent findings from follow-up studies suggest that pancreases with BD-IPMNs have a high risk of developing additional pancreatic cancer, with standardized incidence ratios (SIRs) of 15...
December 2009: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/25655296/liver-biliary-and-pancreatic-injuries-in-pancreaticobiliary-maljunction-model-in-cats
#9
Feng Chen, Lin Tang, Zhi-Qi Zhang, Bing-Wei Jin, Wei-Feng Dong, Jian Wang, Shun-Gen Huang
BACKGROUND: Pancreaticobiliary maljunction is a high risk factor of pancreatitis and biliary tract cancer. How this maljunction affects the liver remains obscure. This study aimed to examine the effects of pancreaticobiliary maljunction on the liver, pancreas and gallbladder in a cat model. METHODS: A model of choledocho-pancreatic side-to-side ductal anastomosis was created in ten cats. Before the procedure, a small piece of tissue from the liver, pancreas and gallbladder was collected as a control...
February 2015: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://www.readbyqxmd.com/read/24305049/p53-status-determines-the-role-of-autophagy-in-pancreatic-tumour-development
#10
Mathias T Rosenfeldt, Jim O'Prey, Jennifer P Morton, Colin Nixon, Gillian MacKay, Agata Mrowinska, Amy Au, Taranjit Singh Rai, Liang Zheng, Rachel Ridgway, Peter D Adams, Kurt I Anderson, Eyal Gottlieb, Owen J Sansom, Kevin M Ryan
Macroautophagy (hereafter referred to as autophagy) is a process in which organelles termed autophagosomes deliver cytoplasmic constituents to lysosomes for degradation. Autophagy has a major role in cellular homeostasis and has been implicated in various forms of human disease. The role of autophagy in cancer seems to be complex, with reports indicating both pro-tumorigenic and tumour-suppressive roles. Here we show, in a humanized genetically-modified mouse model of pancreatic ductal adenocarcinoma (PDAC), that autophagy's role in tumour development is intrinsically connected to the status of the tumour suppressor p53...
December 12, 2013: Nature
https://www.readbyqxmd.com/read/24252270/imaging-heterogeneity-in-the-mitochondrial-redox-state-of-premalignant-pancreas-in-the-pancreas-specific-pten-null-transgenic-mouse-model
#11
He N Xu, Shoko Nioka, Lin Z Li
BACKGROUND: Metabolic alteration is one of the hallmarks of carcinogenesis. We aimed to identify certain metabolic biomarkers for the early detection of pancreatic cancer (PC) using the transgenic PTEN-null mouse model. Pancreas-specific deletion of PTEN in mouse caused progressive premalignant lesions such as highly proliferative ductal metaplasia. We imaged the mitochondrial redox state of the pancreases of the transgenic mice approximately eight months old using the redox scanner, i...
2013: Biomarker Research
https://www.readbyqxmd.com/read/24167322/quantified-adc-histogram-analysis-a-new-method-for-differentiating-mass-forming-focal-pancreatitis-from-pancreatic-cancer
#12
Xiaohong Ma, Xinming Zhao, Han Ouyang, Fei Sun, Hongmei Zhang, Chunwu Zhou
BACKGROUND: As their prognosis and management are different, differentiation of mass-forming focal pancreatitis (FP) from pancreatic adenocarcinoma (PC) is important. However, the similar clinical presentations and imaging features of these conditions, along with inconclusive biopsy results can make such differentiation difficult. PURPOSE: To determine whether apparent diffusion coefficient (ADC) histogram analysis can discriminate between a normal pancreas, FP, and PC...
September 2014: Acta Radiologica
https://www.readbyqxmd.com/read/24083011/study-of-the-avoidable-mortality-in-iran-kerman-province
#13
Mohammadreza Amiresmaili, Narges Khanjani, Mahmood Nekoei Moghadam, Parvaneh Isfahani
BACKGROUND: Recognizing mortality pattern and observing its trend will help us in determining health priorities, allocating health resources and priorities in health section, eliminating main factors of premature deaths and carrying out epidemiological research. OBJECTIVE: The aim of this research was to determine avoidable mortality in Kerman province. MATERIALS AND METHODS: The present study was carried out longitudinal. A checklist was applied for data collection...
April 2013: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/23578383/oxidative-stress-induced-by-inactivation-of-tp53inp1-cooperates-with-krasg12d-to-initiate-and-promote-pancreatic-carcinogenesis-in-the-murine-pancreas
#14
Talal Al Saati, Pascal Clerc, Naïma Hanoun, Sylvain Peuget, Hubert Lulka, Véronique Gigoux, Florence Capilla, Benoît Béluchon, Anne Couvelard, Janick Selves, Louis Buscail, Alice Carrier, Nelson Dusetti, Marlène Dufresne
Tumor protein p53-induced nuclear protein 1 (TP53INP1) is involved in cell stress response. Its expression is lost at the pancreatic intraepithelial neoplasia 1b (PanIN1b)/PanIN2 stage of pancreatic carcinogenesis. Our objective was to determine whether TP53INP1 loss of expression contributes to pancreatic cancer formation in a conditional KrasG12D mouse model. We generated Kras-INP1KO mice using LSL-Kras(G12D/+);Pdx1-Cre(+/-) mice (Kras mice) and TP53INP1(-/-) mice. Analysis of pancreases during ageing shows that in the presence of activated Kras, TP53INP1 loss of expression accelerated PanIN formation and increased pancreatic injury and the number of high-grade lesions as compared with what occurs in Kras mice...
June 2013: American Journal of Pathology
https://www.readbyqxmd.com/read/22990986/wearable-and-implantable-pancreas-substitutes
#15
REVIEW
Leonardo Ricotti, Tareq Assaf, Paolo Dario, Arianna Menciassi
A lifelong-implanted and completely automated artificial or bioartificial pancreas (BAP) is the holy grail for type 1 diabetes treatment, and could be a definitive solution even for other severe pathologies, such as pancreatitis and pancreas cancer. Technology has made several important steps forward in the last years, providing new hope for the realization of such devices, whose feasibility is strictly connected to advances in glucose sensor technology, subcutaneous and intraperitoneal insulin pump development, the design of closed-loop control algorithms for mechatronic pancreases, as well as cell and tissue engineering and cell encapsulation for biohybrid pancreases...
March 2013: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/22776310/laparoscopic-common-hepatic-artery-ligation-and-staging-followed-by-distal-pancreatectomy-with-en-bloc-resection-of-celiac-artery-for-advanced-pancreatic-cancer
#16
V Raut, K Takaori, Y Kawaguchi, M Mizumoto, M Kawaguchi, M Koizumi, S Kodama, A Kida, S Uemoto
INTRODUCTION: Adeno-carcinomas of pancreatic body are usually asymptomatic and progress to advanced stage with involvement of major arteries. Resection of advanced cancer along with en bloc resection of a common hepatic artery and celiac trunk enables a "curative" resections and only possible treatment. However, the celiac axis resection always has a risk of compromising blood supply to liver, resulting in the hepatic insufficiency. We evaluated practicability of a two-stage procedure for the advanced pancreases body cancer, laparoscopic clamping of a common hepatic artery followed by open distal pancreatectomy with en bloc celiac arterial resection to prevent the hepatic insufficiency...
November 2011: Asian Journal of Endoscopic Surgery
https://www.readbyqxmd.com/read/22772764/histone-deacetylases-1-and-3-but-not-2-mediate-cytokine-induced-beta-cell-apoptosis-in-ins-1-cells-and-dispersed-primary-islets-from-rats-and-are-differentially-regulated-in-the-islets-of-type-1-diabetic-children
#17
M Lundh, D P Christensen, M Damgaard Nielsen, S J Richardson, M S Dahllöf, T Skovgaard, J Berthelsen, C A Dinarello, A Stevenazzi, P Mascagni, L G Grunnet, N G Morgan, T Mandrup-Poulsen
AIMS/HYPOTHESIS: Histone deacetylases (HDACs) are promising pharmacological targets in cancer and autoimmune diseases. All 11 classical HDACs (HDAC1-11) are found in the pancreatic beta cell, and HDAC inhibitors (HDACi) protect beta cells from inflammatory insults. We investigated which HDACs mediate inflammatory beta cell damage and how the islet content of these HDACs is regulated in recent-onset type 1 diabetes. METHODS: The rat beta cell line INS-1 and dispersed primary islets from rats, either wild type or HDAC1-3 deficient, were exposed to cytokines and HDACi...
September 2012: Diabetologia
https://www.readbyqxmd.com/read/22255605/laser-interstitial-thermotherapy-for-pancreatic-tumor-ablation-theoretical-model-and-experimental-validation
#18
COMPARATIVE STUDY
P Saccomandi, E Schena, F M Di Matteo, M Pandolfi, M Martino, R Rea, S Silvestri
This study aims to develop and verify a theoretical model to reproduce the thermal response of pancreatic tissue undergone Laser Induced Interstitial Thermotherapy (LITT). The model provides the evaluation of: a) ablated volumes induced by thermal ablation; b) tissue response time to irradiation; and c) heat extinction time. Theoretical volume values were compared with ex vivo healthy tissue and in vivo healthy and neoplastic tissue volume values. The theoretical model takes into account the differences between healthy and neoplastic tissue due to blood perfusion...
2011: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/21737903/the-pattern-of-neural-elements-in-the-islets-of-normal-and-diseased-pancreas-and-in-isolated-islets
#19
Parviz M Pour, Murat Saruc
CONTEXT: The association between islet cells and neural elements, the so-called "neuro-insular complex", has been known for centuries. OBJECTIVE: We examined the expression of beta-III tubulin, in normal pancreases from organ donors, surgical specimens of chronic pancreatitis, surgical specimens of ductal type carcinoma, isolated and purified islets of a 57-year-old male and the pancreases of adult Syrian golden hamsters by immunohistochemistry using a monoclonal antibody to beta-tubulin...
July 2011: JOP: Journal of the Pancreas
https://www.readbyqxmd.com/read/21445789/heterogeneity-of-mitochondrial-redox-state-in-premalignant-pancreas-in-a-pten-null-transgenic-mouse-model
#20
He N Xu, Shoko Nioka, Britton Chance, Lin Z Li
Pancreas-specific deletion of PTEN in mice revealed progressive premalignant lesions such as ductal metaplasia with infrequent malignant transformation. In this study, we aimed at evaluating the mitochondrial redox state of the metaplastic pancreas in a pancreas-specific PTEN null transgenic mouse model. The two intrinsic fluorophores, reduced nicotinamide adenine dinucleotide (NADH) and oxidized flavoproteins (Fp) such as flavin adenine dinucleotide (FAD), in the respiratory chain in mitochondria are sensitive indicators of mitochondrial redox states and have been applied to the studies of mitochondrial function with energy-linked processes...
2011: Advances in Experimental Medicine and Biology
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