Mihir Parikh, Broderick C Hirst, Kimberley A O'Hara, Thane G Maddaford, J Alejandro Austria, Aleksandra Stamenkovic, Liping Yu, Branislav Kura, Bhavana Garg, Thomas Netticadan, Spencer D Proctor, Grant N Pierce
Non-alcoholic fatty liver disease (NAFLD), a significant cause of chronic liver disease, presents a considerable public health concern. Despite this, there is currently no treatment available. This study aimed to investigate dietary flaxseed in the JCR:LA-corpulent rat strain model of NAFLD. Both obese male and female rats were studied along with their lean counterparts after 12 weeks of ingestion of a control diet, or control diet with flaxseed, or high fat, high sucrose (HFHS), or HFHS plus flaxseed. Obese rats showed higher liver weight and increased levels of cholesterol, triglyceride, and saturated fatty acid, which were further elevated in rats on the HFHS diet...
February 6, 2024: Nutrients