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https://www.readbyqxmd.com/read/28528621/using-lean-to-rapidly-and-sustainably-transform-a-behavioral-health-crisis-program-impact-on-throughput-and-safety
#1
Margaret E Balfour, Kathleen Tanner, Paul J Jurica, Dawn Llewellyn, Robert G Williamson, Chris A Carson
BACKGROUND: Lean has been increasingly applied in health care to reduce waste and improve quality, particularly in fast-paced and high-acuity clinical settings such as emergency departments. In addition, Lean's focus on engagement of frontline staff in problem solving can be a catalyst for organizational change. In this study, ConnectionsAZ demonstrates how they applied Lean principles to rapidly and sustainably transform clinical operations in a behavioral health crisis facility. METHODS: A multidisciplinary team of management and frontline staff defined values-based outcome measures, mapped the current and ideal processes, and developed new processes to achieve the ideal...
June 2017: Joint Commission Journal on Quality and Patient Safety
https://www.readbyqxmd.com/read/28526377/orange-juice-allied-to-a-reduced-calorie-diet-results-in-weight-loss-and-ameliorates-obesity-related-biomarkers-a-randomized-controlled-trial
#2
Carolina Ribeiro, Grace Dourado, Thais Cesar
OBJECTIVE: Assumptions have linked orange juice (OJ) consumption with weight gain and adverse effects on health due to its sugar content; however, epidemiologic studies have not shown increased risk for overweight or obesity with the consumption of 100% OJ. The aim of this study was to verify whether the combination of a reduced-calorie diet (RCD) and 100% OJ contribute to weight loss, promote changes in glucose and lipid metabolism, and improve diet quality in obese individuals. METHODS: A randomized controlled trial with 78 obese patients (age 36 ± 1 y, body mass index [BMI] 33 ± 3 kg/m(2)) were enrolled in two groups: Individuals in the OJ group submitted to an RCD that included OJ (500 mL/d), and individuals in the control group submitted to an RCD without OJ...
June 2017: Nutrition
https://www.readbyqxmd.com/read/28492082/metabolomics-approach-in-the-investigation-of-metabolic-changes-in-obese-men-after-24-weeks-of-combined-training
#3
Renata G Duft, Alex Castro, Ivan L P Bonfante, Diego T Brunelli, Mara P T Chacon-Mikahil, Cláudia R Cavaglieri
Obesity is associated with comorbidities related to metabolic disorders due to excess of adipose tissue. Physical exercise has a major role in the prevention of obesity. Combined training (CT), in particular, has been shown to improve markers of health. In this study, we used (1)H NMR-based metabolomics to investigate changes in the metabolism of obese men after 24 weeks of CT. Twenty-two obese (body mass index 31 ± 1.4 kg/m(2)), middle-aged men (48.2 ± 6.1 years) were randomly assigned to a control group (CG, n = 11) or CT group (n = 11)...
May 18, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28481907/relationship-between-anthropometric-parameters-and-open-angle-glaucoma-the-korea-national-health-and-nutrition-examination-survey
#4
Jae Yeun Lee, Tae-Woo Kim, Hyun Tae Kim, Mi Yeon Lee, Hye Won Min, Yu Sam Won, Hyun Seok Kwon, Ki Ho Park, Joon Mo Kim
AIMS: To evaluate the relationships between open-angle glaucoma (OAG) and various anthropometric measurements. DESIGN: Korea National Health and Nutrition Examination Survey (KNHANES), a population-based cross-sectional study using a complex, stratified, multistage, probability-cluster survey. METHODS: A total of 5,255 participants including 247 glaucoma patients, aged ≥ 19 years were included from the KNHANES V database. Glaucoma diagnosis was based on International Society of Geographical and Epidemiological Ophthalmology criteria...
2017: PloS One
https://www.readbyqxmd.com/read/28470137/waste-in-health-information-systems-a-systematic-review
#5
Nadia Awang Kalong, Maryati Yusof
Purpose The purpose of this paper is to discuss a systematic review on waste identification related to health information systems (HIS) in Lean transformation. Design/methodology/approach A systematic review was conducted on 19 studies to evaluate Lean transformation and tools used to remove waste related to HIS in clinical settings. Findings Ten waste categories were identified, along with their relationships and applications of Lean tool types related to HIS. Different Lean tools were used at the early and final stages of Lean transformation; the tool selection depended on the waste characteristic...
May 8, 2017: International Journal of Health Care Quality Assurance
https://www.readbyqxmd.com/read/28453658/androgen-receptor-agonists-increase-lean-mass-improve-cardiopulmonary-functions-and-extend-survival-in-preclinical-models-of-duchenne-muscular-dystrophy
#6
Suriyan Ponnusamy, Ryan D Sullivan, Dahui You, Nadeem Zafar, Chuan He Yang, Thirumagal Thiyagarajan, Daniel L Johnson, Maron L Barrett, Nikki J Koehler, Mayra Star, Erin J Stephenson, Dave Bridges, Stephania A Cormier, Lawrence M Pfeffer, Ramesh Narayanan
Duchenne muscular dystrophy (DMD) is a neuromuscular disease that predominantly affects boys as a result of mutation(s) in the dystrophin gene. DMD is characterized by musculoskeletal and cardiopulmonary complications, resulting in shorter life-span. Boys afflicted by DMD typically exhibit symptoms within 3-5 years of age and declining physical functions before attaining puberty. We hypothesized that rapidly deteriorating health of pre-pubertal boys with DMD could be due to diminished anabolic actions of androgens in muscle, and that intervention with an androgen receptor (AR) agonist will reverse musculoskeletal complications and extend survival...
April 27, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28448584/sarcopenia-in-patients-with-chronic-kidney-disease-not-yet-on-dialysis-analysis-of-the-prevalence-and-associated-factors
#7
Viviane Angelina de Souza, Dílmerson Oliveira, Sérgio Ribeiro Barbosa, José Otávio do Amaral Corrêa, Fernando Antônio Basile Colugnati, Henrique Novais Mansur, Natália Maria da Silva Fernandes, Marcus Gomes Bastos
INTRODUCTION: Sarcopenia is a chronic condition that is associated with aging and characterized by a reduction of muscle mass, strength, and function. Sarcopenia is prevalent in patients with chronic kidney disease (CKD) and associated with increased morbidity and mortality, as well as cardiovascular complications. OBJECTIVES: To investigate the prevalence of sarcopenia in patients with CKD not yet on dialysis and its correlation with clinical and laboratory variables and inflammatory markers...
2017: PloS One
https://www.readbyqxmd.com/read/28441766/fat-mass-is-positively-associated-with-estimated-hip-bone-strength-among-chinese-men-aged-50-years-and-above-with-low-levels-of-lean-mass
#8
Guiyuan Han, Yu-Ming Chen, Hua Huang, Zhanyong Chen, Lipeng Jing, Su-Mei Xiao
This study investigated the relationships of fat mass (FM) and lean mass (LM) with estimated hip bone strength in Chinese men aged 50-80 years (median value: 62.0 years). A cross-sectional study including 889 men was conducted in Guangzhou, China. Body composition and hip bone parameters were generated by dual-energy X-ray absorptiometry (DXA). The relationships of the LM index (LMI) and the FM index (FMI) with bone phenotypes were detected by generalised additive models and multiple linear regression. The associations between the FMI and the bone variables in LMI tertiles were further analysed...
April 24, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28429917/the-impact-of-urbanization-on-the-community-food-environment-in-china
#9
Yang Wu, Hong Xue, Huijun Wang, Chang Su, Shufa Du, Youfa Wang
BACKGROUND AND OBJECTIVES: Research on how urbanization has influenced the food environment in China is limited. The study aimed to examine the impact of urbanization on the food environment in China. METHODS AND STUDY DESIGN: Longitudinal data collected during 1989-2009 from the China Health and Nutrition Survey were used, which covered 9 provinces in China. Urbanicity index (0-10) was assessed using an urbanicity scale. Final analyses included 216 communities...
May 2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28423041/modeling-the-shape-and-composition-of-the-human-body-using-dual-energy-x-ray-absorptiometry-images
#10
John A Shepherd, Bennett K Ng, Bo Fan, Ann V Schwartz, Peggy Cawthon, Steven R Cummings, Stephen Kritchevsky, Michael Nevitt, Adam Santanasto, Timothy F Cootes
There is growing evidence that body shape and regional body composition are strong indicators of metabolic health. The purpose of this study was to develop statistical models that accurately describe holistic body shape, thickness, and leanness. We hypothesized that there are unique body shape features that are predictive of mortality beyond standard clinical measures. We developed algorithms to process whole-body dual-energy X-ray absorptiometry (DXA) scans into body thickness and leanness images. We performed statistical appearance modeling (SAM) and principal component analysis (PCA) to efficiently encode the variance of body shape, leanness, and thickness across sample of 400 older Americans from the Health ABC study...
2017: PloS One
https://www.readbyqxmd.com/read/28408970/differential-regulation-of-cardiac-function-and-intracardiac-cytokines-by-rapamycin-in-healthy-and-diabetic-rats
#11
Christian Luck, Vincent G DeMarco, Abuzar Mahmood, Madhavi P Gavini, Lakshmi Pulakat
Diabetes is comorbid with cardiovascular disease and impaired immunity. Rapamycin improves cardiac functions and extends lifespan by inhibiting the mechanistic target of rapamycin complex 1 (mTORC1). However, in diabetic murine models, Rapamycin elevates hyperglycemia and reduces longevity. Since Rapamycin is an immunosuppressant, we examined whether Rapamycin (750 μg/kg/day) modulates intracardiac cytokines, which affect the cardiac immune response, and cardiac function in male lean (ZL) and diabetic obese Zucker (ZO) rats...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28404506/associations-of-24-hour-sleep-duration-and-ct-derived-measurements-of-muscle-and-bone-the-ages-reykjavik-study
#12
Elisa A Marques, Pedro Figueiredo, Vilmundur Gudnason, Thomas Lang, Gunnar Sigurdsson, Sigurdur Sigurdsson, Thor Aspelund, Kristin Siggeirsdottir, Lenore Launer, Gudny Eiriksdottir, Tamara B Harris
BACKGROUND: Although the importance of sleep on preservation of several physiological functions is well known, the relationship with the two interconnected tissues - muscle and bone is less understood. OBJECTIVES: This study aimed to examine the association of 24-hour sleep duration with mid-thigh muscle composition and proximal femur volumetric bone mineral density (vBMD). METHODS: 2438 men and 3326 women aged 66 to 96years, residents in the Reykjavik area, were included in this cross-sectional study...
July 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28400571/moderate-lifelong-overexpression-of-tuberous-sclerosis-complex-1-tsc1-improves-health-and-survival-in-mice
#13
Hong-Mei Zhang, Vivian Diaz, Michael E Walsh, Yiqiang Zhang
The tuberous sclerosis complex 1/2 (TSC1/2) is an endogenous regulator of the mechanistic target of rapamycin (mTOR). While mTOR has been shown to play an important role in health and aging, the role of TSC1/2 in aging has not been fully investigated. In the current study, a constitutive TSC1 transgenic (Tsc1 (tg) ) mouse model was generated and characterized. mTORC1 signaling was reduced in majority of the tissues, except the brain. In contrast, mTORC2 signaling was enhanced in Tsc1 (tg) mice. Tsc1 (tg) mice are more tolerant to exhaustive exercises and less susceptible to isoproterenol-induced cardiac hypertrophy at both young and advanced ages...
April 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28363839/selection-for-high-aerobic-capacity-has-no-protective-effect-against-obesity-in-laboratory-mice
#14
Julita Sadowska, Andrzej K Gębczyński, Marek Konarzewski
Aerobic capacity (VO2max measured during intensive physical exercise) both trained and intrinsic (i.e. genetically determined) has recently been deemed a good predictor of cardiometabolic risks. However, the underlying mechanisms linking VO2max and health risk factors are not entirely clear, as it seems that not VO2max per se, but rather some correlated traits, like spontaneous physical activity (SPA) are responsible for sustaining the lean phenotype. Here we investigated the link between genetically determined aerobic capacity, SPA and resistance to diet-induced health risks using replicated lines of mice selected for high aerobic capacity during swimming in mid-cold water (25°C) and Randomly Bred control mice...
June 1, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28358788/an-application-of-business-process-management-to-health-care-facilities
#15
Mohsen M D Hassan
The purpose of this article is to help health care facility managers and personnel identify significant elements of their facilities to address, and steps and actions to follow, when applying business process management to them. The ABPMP (Association of Business Process Management Professionals) life-cycle model of business process management is adopted, and steps from Lean, business process reengineering, and Six Sigma, and actions from operations management are presented to implement it. Managers of health care facilities can find in business process management a more comprehensive approach to improving their facilities than Lean, Six Sigma, business process reengineering, and ad hoc approaches that does not conflict with them because many of their elements can be included under its umbrella...
April 2017: Health Care Manager
https://www.readbyqxmd.com/read/28350314/integrating-quality-improvement-and-continuing-professional-development-at-an-academic-medical-center-a-partnership-between-practice-plan-hospital-and-medical-school
#16
Barbara Gold, Dawn England, William Riley, Ginny Jacobs-Halsey, Corinne Webb, Bobbi Daniels
INTRODUCTION: While quality improvement (QI) initiatives can be a highly effective means for improving health care delivery in academic medical centers (AMCs), many health care professionals are not formally trained in basic QI methodology, engaging clinicians in QI activities can be challenging, and there is often a lack of integration and coordination among QI functions (eg, Departments of Quality and Safety, Continuing Professional Development). In our AMC, we undertook a collaborative approach to achieve better vertical and horizontal integration of our QI education efforts...
October 2016: Journal of Continuing Education in the Health Professions
https://www.readbyqxmd.com/read/28333235/ovarian-hormones-and-obesity
#17
Brigitte Leeners, Nori Geary, Philippe N Tobler, Lori Asarian
BACKGROUND: Obesity is caused by an imbalance between energy intake, i.e. eating and energy expenditure (EE). Severe obesity is more prevalent in women than men worldwide, and obesity pathophysiology and the resultant obesity-related disease risks differ in women and men. The underlying mechanisms are largely unknown. Pre-clinical and clinical research indicate that ovarian hormones may play a major role. OBJECTIVE AND RATIONALE: We systematically reviewed the clinical and pre-clinical literature on the effects of ovarian hormones on the physiology of adipose tissue (AT) and the regulation of AT mass by energy intake and EE...
March 2, 2017: Human Reproduction Update
https://www.readbyqxmd.com/read/28329087/clinical-definitions-of-sarcopenia-and-risk-of-hospitalization-in-community-dwelling-older-men-the-osteoporotic-fractures-in-men-study
#18
Peggy M Cawthon, Li-Yung Lui, Brent C Taylor, Charles E McCulloch, Jane A Cauley, Jodi Lapidus, Eric Orwoll, Kristine E Ensrud
Background: The association between various definitions of sarcopenia and hospitalization has not been evaluated in community-dwelling older men. Methods: We used data from 1,516 participants at Visit 3 of the Osteoporotic Fractures in Men (MrOS) study who also had linked Medicare Fee-For-Service Claims data available. We examined the association between several sarcopenia definitions (International Working Group, European Working Group for Sarcopenia in Older Persons, Foundation for the NIH Sarcopenia Project, Baumgartner, and Newman) and hospitalization, using two-part ("hurdle") models, adjusted for age, clinical center, functional limitations, self-reported health, comorbidity, and cognitive function...
January 18, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28322093/peripheral-invariant-natural-killer-t-cell-deficiency-in-metabolically-unhealthy-but-normal-weight-versus-metabolically-healthy-but-obese-individuals
#19
Xiao-Li Wang, Xiang-Yun Chang, Xiao-Xiao Tang, Zhi-Gang Chen, Ting Zhou, Kan Sun
Objective To investigate the proportion of circulating invariant natural killer T (iNKT) cells in four body health types. Methods In this cross-sectional study, participants were classified into four body health types according to the body mass index and metabolic status: metabolically healthy and normal weight (MHNW), metabolically unhealthy but normal weight (MUNW), metabolically healthy but obese (MHO), or metabolically unhealthy and obese (MUO). Demographic and clinical characteristics were measured, and the homeostasis model assessment of insulin resistance (HOMA-IR) and visceral adiposity index (VAI) were calculated...
December 2016: Journal of International Medical Research
https://www.readbyqxmd.com/read/28292922/the-association-of-the-c-reactive-protein-inflammatory-biomarker-with-breast-cancer-incidence-and-mortality-in-the-women-s-health-initiative
#20
Sandahl H Nelson, Theodore M Brasky, Ruth E Patterson, Gail A Laughlin, Donna Kritz-Silverstein, Beatrice J Edwards, Dorothy Lane, Thomas E Rohan, Gloria Y F Ho, JoAnn E Manson, Andrea Z LaCroix
PURPOSE: To examine associations of pre-diagnosis high-sensitivity C-reactive (hsCRP) with breast cancer incidence and post-diagnosis survival and to assess whether associations are modified by Body Mass Index (BMI). METHODS: A prospective analysis of the Women's Health Initiative was conducted among 17,841 cancer free postmenopausal women with baseline hsCRP measurements. Cox proportional hazards models were used to examine associations between hsCRP concentrations and: 1) breast cancer risk (n cases=1,114) and 2) all-cause mortality after breast cancer diagnosis...
March 14, 2017: Cancer Epidemiology, Biomarkers & Prevention
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