keyword
https://read.qxmd.com/read/38540328/regulation-of-myo-mir-24-3p-on-the-myogenesis-and-fiber-type-transformation-of-skeletal-muscle
#1
JOURNAL ARTICLE
Danyang Fan, Yilong Yao, Yanwen Liu, Chao Yan, Fanqinyu Li, Shilong Wang, Mei Yu, Bingkun Xie, Zhonglin Tang
Skeletal muscle plays critical roles in providing a protein source and contributing to meat production. It is well known that microRNAs (miRNAs) exert important effects on various biological processes in muscle, including cell fate determination, muscle fiber morphology, and structure development. However, the role of miRNA in skeletal muscle development remains incompletely understood. In this study, we observed a critical miRNA, miR-24-3p, which exhibited higher expression levels in Tongcheng (obese-type) pigs compared to Landrace (lean-type) pigs...
February 21, 2024: Genes
https://read.qxmd.com/read/38528359/anthropometric-predictors-of-health-related-quality-of-life-in-obese-patients-attending-a-tertiary-hospital-in-nnewi-south-east-nigeria-a-cross-sectional-study
#2
JOURNAL ARTICLE
Amaka L Obi-Nwosu, Betrand O Nwosu, Sylvia I Ezemenahi, Daniella I Obi-Nwosu, Chinekwu S Nwosu, Bede C Azudialu, Chukwudi S Ojiakor, Uche M Umeh, Emeka C Izuchukwu, Chika I Ofiaeli, Chinyere M Ulochukwu
BACKGROUND: Obesity as a disorder with excess body fat directly decreases quality of life. While Body Mass Index (BMI) has been used largely in health studies as a measure of obesity, it is largely unable to differentiate between body fat and lean body mass, hence other anthropometric measures can be used to assess body fat. OBJECTIVE: To determine the association of anthropometric indicators with health-related quality of life (HRQoL) in obese adults. MATERIALS AND METHODS: A cross-sectional study of obese adults (BMI ≥30kg/m2) attending the general outpatient clinic was conducted over four months...
March 1, 2024: Nigerian Journal of Clinical Practice
https://read.qxmd.com/read/38515601/evaluating-the-metropolitan-public-health-preparedness-for-pandemics-using-entropy-topsis-if
#3
JOURNAL ARTICLE
Jin Liu, Allen Wood Liu, Xingye Li, Hui Li, Wenwei Luo, Wei Chen
INTRODUCTION: Metropolitan governance's efficacy is regularly gauged by its capability for public health preparedness, a critical component, particularly in the post-pandemic climate, as global cities reassess their mitigation abilities. This process has broader implications, curbing mortality rates and amplifying sustainability. Current methodologies for preparedness assessment lean primarily on either Subjective Evaluation-Based Assessment (SBA), predicated on experts' input on various capacity indicators, or they opt for Data-Based quantitative Assessments (DBA), chiefly utilizing public statistic data...
2024: Frontiers in Public Health
https://read.qxmd.com/read/38509635/development-of-a-modified-3d-region-proposal-network-for-lung-nodule-detection-in-computed-tomography-scans-a-secondary-analysis-of-lung-nodule-datasets
#4
JOURNAL ARTICLE
Chia-Ying Lin, Shu-Mei Guo, Jenn-Jier James Lien, Tzung-Yi Tsai, Yi-Sheng Liu, Chao-Han Lai, I-Lin Hsu, Chao-Chun Chang, Yau-Lin Tseng
BACKGROUND: Low-dose computed tomography (LDCT) has been shown useful in early lung cancer detection. This study aimed to develop a novel deep learning model for detecting pulmonary nodules on chest LDCT images. METHODS: In this secondary analysis, three lung nodule datasets, including Lung Nodule Analysis 2016 (LUNA16), Lung Nodule Received Operation (LNOP), and Lung Nodule in Health Examination (LNHE), were used to train and test deep learning models. The 3D region proposal network (RPN) was modified via a series of pruning experiments for better predictive performance...
March 20, 2024: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
https://read.qxmd.com/read/38476672/association-between-tyg-index-trajectory-and-new-onset-lean-nafld-a-longitudinal-study
#5
JOURNAL ARTICLE
Haoshuang Liu, Jingfeng Chen, Qian Qin, Su Yan, Youxiang Wang, Jiaoyan Li, Suying Ding
OBJECTIVE: The purpose of this manuscript is to identify longitudinal trajectories of changes in triglyceride glucose (TyG) index and investigate the association of TyG index trajectories with risk of lean nonalcoholic fatty liver disease (NAFLD). METHODS: Using data from 1,109 participants in the Health Management Cohort longitudinal study, we used Latent Class Growth Modeling (LCGM) to develop TyG index trajectories. Using a Cox proportional hazard model, the relationship between TyG index trajectories and incident lean NAFLD was analyzed...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38475215/wrist-based-fall-detection-towards-generalization-across-datasets
#6
JOURNAL ARTICLE
Vanilson Fula, Plinio Moreno
Increasing age is related to a decrease in independence of movement and with this decrease comes falls, millions of falls occur every year and the most affected people are the older adults. These falls usually have a big impact on health and independence of the older adults, as well as financial impact on the health systems. Thus, many studies have developed fall detectors from several types of sensors. Previous studies related to the creation of fall detection systems models use only one dataset that usually has a small number of samples...
March 5, 2024: Sensors
https://read.qxmd.com/read/38452917/glyphosate-exposure-muscular-health-and-functional-limitations-in-middle-aged-and-older-adults
#7
JOURNAL ARTICLE
Sara Jauregui-Zunzunegui, Fernando Rodríguez-Artalejo, María Tellez-Plaza, Esther García-Esquinas
BACKGROUND: Glyphosate is the most widely used herbicide worldwide, both in domestic and industrial settings. Experimental research in animal models has demonstrated changes in muscle physiology and reduced contractile strength associated with glyphosate exposure, while epidemiological studies have shown associations between glyphosate exposure and adverse health outcomes in critical biological systems affecting muscle function. METHODS: This study used data from a nationally representative survey of the non-institutionalized U...
March 5, 2024: Environmental Research
https://read.qxmd.com/read/38442653/greater-upper-limb-muscle-mass-associated-with-reduced-cardiovascular-mortality-compared-with-other-muscle-groups-in-diabetics
#8
JOURNAL ARTICLE
Chang Liu, Lin Hua, Zhong Xin
OBJECTIVES: Although muscle mass and its distribution have been shown to affect prognosis, the association between regional muscle mass and cardiovascular mortality risk in diabetic patients remains unclear. METHODS: This prospective cohort study analyzed data from 2166 individuals with diabetes who participated in the National Health and Nutrition Survey conducted in the United States between 2003 to 2006 and 2011 to 2018, linked to the National Death Index. Weighted Kaplan-Meier analysis and multivariable Cox proportional hazards models were used to explore the association between different regional lean mass and cardiovascular mortality...
February 8, 2024: Nutrition
https://read.qxmd.com/read/38430300/p21-activated-kinase-1-signaling-is-required-to-preserve-adipose-tissue-homeostasis-and-cardiac-function
#9
JOURNAL ARTICLE
Marcos Munoz, Christopher Solis, Maximilian McCann, Jooman Park, Koreena Rafael-Clyke, Shamim A K Chowdhury, Yuwei Jiang, Paola C Rosas
While P21-activated kinase-1 (PAK1) has been extensively studied in relation to cardiovascular health and glucose metabolism, its roles within adipose tissue and cardiometabolic diseases are less understood. In this study, we explored the effects of PAK1 deletion on energy balance, adipose tissue homeostasis, and cardiac function utilizing a whole-body PAK1 knockout (PAK1-/- ) mouse model. Our findings revealed that body weight differences between PAK1-/- and WT mice emerged at 9 weeks of age, with further increases observed at 12 weeks...
March 2, 2024: Molecular and Cellular Biochemistry
https://read.qxmd.com/read/38429434/smartphone-keyboard-dynamics-predict-affect-in-suicidal-ideation
#10
JOURNAL ARTICLE
Loran Knol, Anisha Nagpal, Imogen E Leaning, Elena Idda, Faraz Hussain, Emma Ning, Tory A Eisenlohr-Moul, Christian F Beckmann, Andre F Marquand, Alex Leow
While digital phenotyping provides opportunities for unobtrusive, real-time mental health assessments, the integration of its modalities is not trivial due to high dimensionalities and discrepancies in sampling frequencies. We provide an integrated pipeline that solves these issues by transforming all modalities to the same time unit, applying temporal independent component analysis (ICA) to high-dimensional modalities, and fusing the modalities with linear mixed-effects models. We applied our approach to integrate high-quality, daily self-report data with BiAffect keyboard dynamics derived from a clinical suicidality sample of mental health outpatients...
March 1, 2024: NPJ Digital Medicine
https://read.qxmd.com/read/38427692/high-fat-diet-is-associated-with-gut-microbiota-dysbiosis-and-decreased-gut-microbial-derived-metabolites-related-to-metabolic-health-in-young-g%C3%A3-ttingen-minipigs
#11
JOURNAL ARTICLE
Ditte Olsen Lützhøft, Cecilie Bækgård, Elizabeth Wimborne, Ellen Marie Straarup, Karen-Margrethe Pedersen, Jonathan R Swann, Henrik Duelund Pedersen, Kim Kristensen, Line Morgills, Dennis Sandris Nielsen, Axel Kornerup Hansen, Marianne Kronborg Bracken, Susanna Cirera, Berit Østergaard Christoffersen
The objectives were 1) to characterize a Göttingen Minipig model of metabolic syndrome regarding its colon microbiota and circulating microbial products, and 2) to assess whether ovariectomized female and castrated male minipigs show similar phenotypes. Twenty-four nine-week-old Göttingen Minipigs were allocated to four groups based on sex and diet: ovariectomized females and castrated males fed either chow or high-fat diet (HFD) for 12 weeks. At study end, body composition and plasma biomarkers were measured, and a mixed meal tolerance test (MMT) and an intravenous glucose tolerance test (IVGTT) were performed...
2024: PloS One
https://read.qxmd.com/read/38421203/new-aspects-characterizing-non-obese-nafld-by-the-analysis-of-the-intestinal-flora-and-metabolites-using-a-mouse-model
#12
JOURNAL ARTICLE
Wenji Zhang, Wenli Cheng, JingHui Li, Zhenrui Huang, Hui Lin, Wenjuan Zhang
UNLABELLED: Non-alcoholic fatty liver disease (NAFLD) is a major public health problem due to the high incidence affecting approximately one-third of the world's population. NAFLD is usually linked to obesity and excessive weight. A subset of patients with NAFLD expresses normal or low body mass index; thus, the condition is called non-obese NAFLD or lean NAFLD. However, patients and healthcare professionals have little awareness and understanding of NAFLD in non-obese individuals. Furthermore, preclinical results from non-obese animal models with NAFLD are unclear...
February 29, 2024: MSystems
https://read.qxmd.com/read/38407554/disparities-among-ethnic-groups-in-mortality-and-outcomes-among-adults-with-masld-a-multicenter-study
#13
JOURNAL ARTICLE
Majd B Aboona, Claire Faulkner, Pooja Rangan, Cheng Han Ng, Daniel Q Huang, Mark Muthiah, Moises I Nevah Rubin, Ma Ai Thanda Han, Michael B Fallon, Donghee Kim, Vincent L Chen, Karn Wijarnpreecha
BACKGROUND: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the leading cause of chronic liver disease and 10%-20% occurs in lean individuals. There is little data in the literature regarding outcomes in an ethnically-diverse patient populations with MASLD. Thus, we aim to investigate the natural history and ethnic disparities of MASLD patients in a diverse population, and stratified by body mass index categories. METHODS: We conducted a retrospective multicenter study on patients with MASLD at the Banner Health System from 2012 to 2022...
February 26, 2024: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/38398791/beneficial-effects-of-dietary-flaxseed-on-non-alcoholic-fatty-liver-disease
#14
JOURNAL ARTICLE
Mihir Parikh, Broderick C Hirst, Kimberley A O'Hara, Thane G Maddaford, J Alejandro Austria, Aleksandra Stamenkovic, Liping Yu, Branislav Kura, Bhavana Garg, Thomas Netticadan, Spencer D Proctor, Grant N Pierce
Non-alcoholic fatty liver disease (NAFLD), a significant cause of chronic liver disease, presents a considerable public health concern. Despite this, there is currently no treatment available. This study aimed to investigate dietary flaxseed in the JCR:LA-corpulent rat strain model of NAFLD. Both obese male and female rats were studied along with their lean counterparts after 12 weeks of ingestion of a control diet, or control diet with flaxseed, or high fat, high sucrose (HFHS), or HFHS plus flaxseed. Obese rats showed higher liver weight and increased levels of cholesterol, triglyceride, and saturated fatty acid, which were further elevated in rats on the HFHS diet...
February 6, 2024: Nutrients
https://read.qxmd.com/read/38393932/research-on-the-construction-of-information-based-nursing-quality-control-system-based-on-deep-learning-model-under-the-lean-perspective
#15
JOURNAL ARTICLE
Wan Pan, Yan Zhou, Yueping Ji, Lianfang Zhou, Li Wang
OBJECTIVE: In order to improve nursing quality management and protect patient medical safety, it is necessary to change the default mode and completely integrate information technology and nursing quality control utilising lean management. METHODS: A database was created, the nurse quality control scoring standard was entered into the computer and after the inspection, and various inspection reports were entered into the computer to precisely and promptly preserve data...
January 30, 2024: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://read.qxmd.com/read/38380888/bidirectional-relationships-between-muscularity-oriented-disordered-eating-and-mental-health-constructs-a-prospective-study
#16
JOURNAL ARTICLE
Cleo Anderson, Mariel Messer, Zoe McClure, Claudia Liu, Jake Linardon
Muscularity-oriented disordered eating (MODE) is a novel class of eating behaviors characterised by abnormal dietary alterations aimed towards building lean muscle. Although traditionally shown to affect men, emerging evidence suggests that increasingly more women are striving for the muscular and lean ideal, resulting in engagement of MODE behaviors. Prior research examining MODE in women is limited, yet emerging evidence from cross-sectional studies have established associations between MODE and poor mental health indices in this population...
February 21, 2024: Eating Disorders
https://read.qxmd.com/read/38374121/integrated-meta-omics-reveals-the-regulatory-landscape-involved-in-lipid-metabolism-between-pig-breeds
#17
JOURNAL ARTICLE
Jiajie Sun, Fang Xie, Jing Wang, Junyi Luo, Ting Chen, Qingyan Jiang, Qianyun Xi, George E Liu, Yongliang Zhang
BACKGROUND: Domesticated pigs serve as an ideal animal model for biomedical research and also provide the majority of meat for human consumption in China. Porcine intramuscular fat content associates with human health and diseases and is essential in pork quality. The molecular mechanisms controlling lipid metabolism and intramuscular fat accretion across tissues in pigs, and how these changes in response to pig breeds, remain largely unknown. RESULTS: We surveyed the tissue-resident cell types of the porcine jejunum, colon, liver, and longissimus dorsi muscle between Lantang and Landrace breeds by single-cell RNA sequencing...
February 20, 2024: Microbiome
https://read.qxmd.com/read/38366979/understanding-the-electrochemical-extraction-of-lithium-from-ultradilute-solutions
#18
JOURNAL ARTICLE
Kaige Sun, Mike Tebyetekerwa, Xiangkang Zeng, Zhuyuan Wang, Timothy T Duignan, Xiwang Zhang
The electrochemical extraction of lithium (Li) from aqueous sources using electrochemical means is a promising direct Li extraction technology. However, to this date, most electrochemical Li extraction studies are confined to Li-rich brine, neglecting the practical and existing Li-lean resources, with their overall extraction behaviors currently not fully understood. More still, the effect of elevated sodium (Na) concentrations typically found in most Li-lean water sources on Li extraction is unclear. Hence, in this work, we first understand the electrochemical Li extraction behaviors from ultradilute solutions using spinel lithium manganese oxide as the model electrode...
February 17, 2024: Environmental Science & Technology
https://read.qxmd.com/read/38364216/lasso-derived-model-for-the-prediction-of-lean-non-alcoholic-fatty-liver-disease-in-examinees-attending-a-routine-health-check-up
#19
JOURNAL ARTICLE
Chiao-Lin Hsu, Pin-Chieh Wu, Fu-Zong Wu, Hsien-Chung Yu
BACKGROUND: Lean individuals with non-alcohol fatty liver disease (NAFLD) often have normal body size but abnormal visceral fat. Therefore, an alternative to body mass index should be considered for prediction of lean-NAFLD. This study aimed to use representative visceral fat links with other laboratory parameters using the least absolute shrinkage and selection operator (LASSO) method to construct a predictive model for lean-NAFLD. METHODS: This retrospective cross-sectional analysis enrolled 2325 subjects with BMI < 24 kg/m2 from medical records of 51,271 examinees who underwent a routine health check-up...
December 2024: Annals of Medicine
https://read.qxmd.com/read/38360677/assessing-support-for-mental-health-policies-among-policy-influencers-and-the-general-public-in-alberta-and-manitoba-canada
#20
JOURNAL ARTICLE
Candace I J Nykiforuk, Mathew Thomson, Kimberley D Curtin, Ian Colman, T Cameron Wild, Elaine Hyshka
BACKGROUND: There is a need to improve mental health policy in Canada to address the growing population burden of mental illness. Understanding support for policy options is critical for advocacy efforts to improve mental health policy. Our purpose was to describe support for population-level healthy public policies to improve mental health among policy influencers and the general public in Alberta and Manitoba; and, identify associations between levels of support and sociodemographic variables and relative to the Nuffield Bioethics Intervention Ladder framework...
February 15, 2024: International Journal of Mental Health Systems
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