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https://www.readbyqxmd.com/read/29778256/hepatitis-c-care-in-the-department-of-veterans-affairs-building-a-foundation-for-success
#1
REVIEW
Pamela S Belperio, Maggie Chartier, Rachel I Gonzalez, Angela M Park, David B Ross, Tim R Morgan, Lisa I Backus
The Department of Veterans Affairs (VA) has made significant progress in treating hepatitis C virus, experiencing more than a 75% reduction in veterans remaining to be treated since the availability of oral direct-acting antivirals. Hepatitis C Innovation Teams use lean process improvement and system redesign, resulting in practice models that address gaps in care. The key to success is creative improvements in veteran access to providers, including expanded use of nonphysician providers, video telehealth, and electronic technologies...
June 2018: Infectious Disease Clinics of North America
https://www.readbyqxmd.com/read/29766286/attenuation-of-the-association-between-sugar-sweetened-beverages-and-diabetes-risk-by-adiposity-adjustment-a-secondary-analysis-of-national-health-survey-data
#2
Yi Jing, Thang S Han, Majid M Alkhalaf, Michael E J Lean
PURPOSE: While weight gain and obesity are the dominant factors, dietary sugar and specifically sugar-sweetened beverages (SSB) has been implicated in causing type 2 diabetes (T2DM). We assessed how much of the apparent effect of SSB is explained by adiposity, but not captured by adjustment for BMI, which is a poor index of body fat. METHODS: We examined data from 5187 adults (mean age 50.8 years, SD = 16.4, 172 (3.3%) T2DM), from the Scottish Health Survey 2003 and 2008-2010 databases...
May 15, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29751833/patterns-of-early-life-body-mass-index-and-childhood-overweight-and-obesity-status-at-eight-years-of-age
#3
Joseph M Braun, Heidi J Kalkwarf, George D Papandonatos, Aimin Chen, Bruce P Lanphear
BACKGROUND: Excess weight gain in infancy and childhood is associated with increased risk of subsequent obesity. Identifying patterns of infancy and childhood weight gain associated with subsequent obesity or overweight status could help identify children at highest risk. Thus, we examined patterns of infancy and early childhood BMI in relation to mid-childhood overweight and obesity status. METHODS: In a prospective cohort of 215 children from Cincinnati, OH (born: 2003-2006), we measured weight and length or height at ages 4 weeks and 1, 2, 3, 4, 5, and 8 years...
May 11, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29701911/dysmobility-syndrome-independently-increases-fracture-risk-in-the-osteoporotic-fractures-in-men-mros-prospective-cohort-study
#4
Bjoern Buehring, Karen E Hansen, Brian L Lewis, Steven R Cummings, Nancy E Lane, Neil Binkley, Kristine E Ensrud, Peggy M Cawthon
We proposed the term "dysmobility syndrome" (DS) to identify individuals with impaired musculoskeletal health, a risk factor for falls and fractures. Whether DS is associated with increased risk of incident fracture is unknown. The "Osteoporotic Fractures in Men" study enrolled 5994 men ages ≥65 years, between March 2000 and April 2002. We used baseline data to determine whether DS increased fracture risk, independent of FRAX. Men met DS criteria at baseline if they had ≥3 of the following: appendicular lean mass/height2 <7...
April 27, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29701774/associations-between-plasma-chemerin-concentrations-and-bone-quality-in-adults-from-the-general-population
#5
Lejla Kadric, Stephanie Zylla, Matthias Nauck, Henry Völzke, Nele Friedrich, Anke Hannemann
Chemerin is an adipokine associated with parameters of inflammation and the metabolic syndrome. Small observational studies suggested that high circulating chemerin levels are also related to bone erosion. We aimed to determine whether plasma chemerin levels are related to bone quality in the general population and to investigate the influence of body mass index (BMI) on that relation. For our analyses we obtained data from 3,583 adults who participated in the population-based Study of Health in Pomerania (SHIP)-Trend...
April 25, 2018: Endocrinology
https://www.readbyqxmd.com/read/29695710/maternal-obesity-during-lactation-may-protect-offspring-from-high-fat-diet-induced-metabolic-dysfunction
#6
Jenifer Monks, David J Orlicky, Adrianne L Stefanski, Andrew E Libby, Elise S Bales, Michael C Rudolph, Ginger C Johnson, Vanessa D Sherk, Matthew R Jackman, Kayla Williamson, Nichole E Carlson, Paul S MacLean, James L McManaman
BACKGROUND/OBJECTIVES: The current obesity epidemic has spurred exploration of the developmental origin of adult heath and disease. A mother's dietary choices and health can affect both the early wellbeing and lifelong disease-risk of the offspring. SUBJECTS/METHODS: To determine if changes in the mother's diet and adiposity have long-term effects on the baby's metabolism, independently from a prenatal insult, we utilized a mouse model of diet-induced-obesity and cross-fostering...
April 25, 2018: Nutrition & Diabetes
https://www.readbyqxmd.com/read/29694491/multidisciplinary-and-motivational-intervention-for-the-treatment-of-low-income-brazilian-obese-adolescents-pilot-study
#7
Andrea Rocha Filgueiras, Ana Lydia Sawaya
OBJECTIVE: To test a multidisciplinary and motivational intervention for the treatment of Brazilian obese and low-income adolescents (Z score>2 BMI-for-age) that used nutritional counseling without dietary control. METHODS: An intervention protocol was developed including periodical nutritional education workshops, individual nutritional counseling guided by the stages of eating behavior of the Trans Theoretical Model of Behavior Change, physical exercise, psychological counseling, recreational activities, and clinical follow-up for 13 months in a sample of 21 adolescents (11-17 years old)...
April 23, 2018: Revista Paulista de Pediatria: Orgão Oficial da Sociedade de Pediatria de São Paulo
https://www.readbyqxmd.com/read/29670769/associations-between-ace-inhibitors-angiotensin-receptor-blockers-and-lean-body-mass-in-community-dwelling-older-women
#8
Jennifer W Bea, Sylvia Wassertheil-Smoller, Betsy C Wertheim, Yann Klimentidis, Zhao Chen, Oleg Zaslavsky, Todd M Manini, Catherine R Womack, Candyce H Kroenke, Andrea Z LaCroix, Cynthia A Thomson
Studies suggest that ACE-inhibitors (ACE-I) and angiotensin receptor blockers (ARBs) may preserve skeletal muscle with aging. We evaluated longitudinal differences in lean body mass (LBM) among women diagnosed with hypertension and classified as ACE-I/ARB users and nonusers among Women's Health Initiative participants that received dual energy X-ray absorptiometry scans to estimate body composition ( n =10,635) at baseline and at years 3 and 6 of follow-up. Of those, 2642 were treated for hypertension at baseline...
2018: Journal of Aging Research
https://www.readbyqxmd.com/read/29652901/early-postnatal-soluble-fgfr3-therapy-prevents-the-atypical-development-of-obesity-in-achondroplasia
#9
Celine Saint-Laurent, Stephanie Garcia, Vincent Sarrazy, Karine Dumas, Florence Authier, Sophie Sore, Albert Tran, Philippe Gual, Isabelle Gennero, Jean-Pierre Salles, Elvire Gouze
BACKGROUND: Achondroplasia is a rare genetic disease is characterized by abnormal bone development and early obesity. While the bone aspect of the disease has been thoroughly studied, early obesity affecting approximately 50% of them during childhood has been somewhat neglected. It nevertheless represents a major health problem in these patients, and is associated to life-threatening complications including increasing risk of cardiovascular pathologies. We have thus decided to study obesity in patients and to use the mouse model to evaluate if soluble FGFR3 therapy, an innovative treatment approach for achondroplasia, could also impact the development of this significant complication...
2018: PloS One
https://www.readbyqxmd.com/read/29649572/associations-of-sarcopenic-obesity-with-the-metabolic-syndrome-and-insulin-resistance-over-five-years-in-older-men-the-concord-health-and-ageing-in-men-project
#10
David Scott, Robert Cumming, Vasi Naganathan, Fiona Blyth, David G Le Couteur, David J Handelsman, Markus Seibel, Louise M Waite, Vasant Hirani
PURPOSE: Previous cross-sectional studies investigating associations of sarcopenic obesity with metabolic syndrome (MetS) and insulin resistance have not utilised consensus definitions of sarcopenia. We aimed to determine associations of sarcopenic obesity with MetS and insulin resistance over five years in community-dwelling older men. METHODS: 1231 men aged ≥70 years had appendicular lean mass (ALM) and body fat percentage assessed by dual-energy X-ray absorptiometry and hand grip strength and gait speed tests...
April 9, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29619669/longitudinal-associations-of-lifetime-adiposity-with-leukocyte-telomere-length-and-mitochondrial-dna-copy-number
#11
Dong Hang, Hongmei Nan, Ane Sørlie Kværner, Immaculata De Vivo, Andrew Tan Chan, Zhibin Hu, Hongbing Shen, Edward Giovannucci, Mingyang Song
Adiposity may cause adverse health outcomes by increasing oxidative stress and systemic inflammation, which can be reflected by altered telomere length (TL) and mitochondrial DNA copy number (mtCN) in peripheral blood leukocytes. However, little is known about the influence of lifetime adiposity on TL and mtCN in later life. This study was performed to investigate the associations of lifetime adiposity with leukocyte TL and mtCN in 9613 participants from the Nurses' Health Study. A group-based trajectory modelling approach was used to create trajectories of body shape from age 5 through 60 years, and a genetic risk score (GRS) was created based on 97 known adiposity susceptibility variants...
April 4, 2018: European Journal of Epidemiology
https://www.readbyqxmd.com/read/29604604/an-exploration-of-peer-assisted-learning-in-undergraduate-nursing-students-in-paediatric-clinical-settings-an-ethnographic-study
#12
Matthew C Carey, Anna Chick, Bridie Kent, Jos M Latour
BACKGROUND: Peer-assisted leaning relates to the acquisition of knowledge and skills through shared learning of matched equals. The concept has been explored within the field of nurse education across a range of learning environments, but its impact in practice is still relatively unknown. This paper reports on findings when observing paediatric undergraduate nursing students who engage in PAL within the clinical practice setting. OBJECTIVES: The aim of this paper is to report the findings of a study undertaken to explore peer-assisted learning in undergraduate nursing students, studying children's health, in the clinical practice setting...
March 22, 2018: Nurse Education Today
https://www.readbyqxmd.com/read/29570139/prevalence-of-suspected-nonalcoholic-fatty-liver-disease-in-lean-adolescents-in-the-united-states
#13
Praveen Kumar Conjeevaram Selvakumar, Mohammad Nasser Kabbany, Rocio Lopez, Maria S Rayas, Jane L Lynch, Naim Alkhouri
OBJECTIVES: Nonalcoholic fatty liver disease (NAFLD) can develop in lean subjects referred to as lean NAFLD. We aim to evaluate the prevalence and risk factors of NAFLD in lean adolescents in the United States (US). METHODS: Cross sectional data from 1482 lean subjects (body mass index < 85 percentile) aged between 12 and 18 years, who were enrolled in the National Health and Examination Survey during the 2005-2014 cycles were included. We defined suspected NAFLD as alanine aminotransferase > 25...
March 21, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29555095/continuing-conversations-about-adverse-childhood-experiences-aces-screening-a-public-health-perspective
#14
Shanta R Dube
Currently, in the U.S. and worldwide, childhood trauma is a public health crisis. Childhood adversities, such as abuse, neglect, and related household stressors, are common, interrelated and contribute to multiple adverse social, behavioral and health outcomes throughout the lifespan. The present article provides further discussion regarding adverse childhood experiences (ACEs) screening in healthcare utilizing the etic and emic perspectives. Screening in the healthcare system leans toward the etic view: objective observations of symptoms, which may then lead to intervention delivery...
March 16, 2018: Child Abuse & Neglect
https://www.readbyqxmd.com/read/29508038/mediterranean-diet-diet-quality-and-bone-mineral-content-in-adolescents-the-helena-study
#15
C Julián, I Huybrechts, L Gracia-Marco, E M González-Gil, Á Gutiérrez, M González-Gross, A Marcos, K Widhalm, A Kafatos, G Vicente-Rodríguez, L A Moreno
Dietary scores, rather than individual nutrients, allow exploring associations between overall diet and bone health. The aim of the present study was to assess the associations between the Mediterranean Diet Score for Adolescents (MDS-A) and the Diet Quality Index for Adolescents (DQI-A) and bone mineral content (BMC) among Spanish adolescents. Our results do not support an association between dietary scores or indices and BMC in adolescents. INTRODUCTION: To assess the associations between the MDS-A and a DQI-A with the BMC measured with dual-energy X-ray absorptiometry...
March 5, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29499371/association-between-involuntary-weight-loss-with-low-muscle-mass-and-health-related-quality-of-life-in-community-dwelling-older-adults-nationwide-surveys-knhanes-2008-2011
#16
Miji Kim, Junghoon Kim, Chang Won Won
OBJECTIVES: To investigate the relationship between involuntary weight loss with low muscle mass and health-related quality of life in a large representative sample of older adults. METHODS: A nationwide cross-sectional study based on data from the Korea National Health and Nutritional Examination Survey, 2008 to 2011. Study participants included 2249 individuals aged ≥70 years. The participants reported an unintentional weight loss >3 kg in the past year...
June 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29490638/dietary-patterns-are-influenced-by-socio-demographic-conditions-of-women-in-childbearing-age-a-cohort-study-of-pregnant-women
#17
Juliana Araujo Teixeira, Teresa Gontijo Castro, Cameron C Grant, Clare R Wall, Ana Lúcia da Silva Castro, Rossana Pulcineli Vieira Francisco, Sandra Elisabete Vieira, Silvia Regina Dias Medici Saldiva, Dirce Maria Marchioni
BACKGROUND: Women's health during their reproductive years and whilst pregnant has implications for their children's health, both in utero and during childhood. Associations of women's pre-pregnancy dietary patterns (DP) with maternal socio-demographic characteristics and nutrient intake were investigated in ProcriAr cohort study in São Paulo/Brazil, 2012. METHODS: The DPs of 454 women were investigated by principal component factor analysis, using dietary information from a validated 110-item food frequency questionnaire...
March 1, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29479645/association-of-sitting-time-and-breaks-in-sitting-with-muscle-mass-strength-function-and-inflammation-in-community-dwelling-older-adults
#18
N Reid, G N Healy, J Gianoudis, M Formica, P A Gardiner, E E Eakin, C A Nowson, R M Daly
The mechanisms through which excessive sitting time impacts health are important to understand. This study found that each hour of sitting per day was not associated with physical function, although associations with poor body composition were observed. Reducing sitting time for improved weight management in older adults needs further exploration. INTRODUCTION: To examine the association of sitting time and breaks in sitting time with muscle mass, strength, function, and inflammation in older Australians...
February 26, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29476104/exploring-the-link-between-serum-phosphate-levels-and-low-muscle-strength-dynapenia-and-sarcopenia
#19
Yuan-Yuei Chen, Tung-Wei Kao, Cheng-Wai Chou, Chen-Jung Wu, Hui-Fang Yang, Ching-Huang Lai, Li-Wei Wu, Wei-Liang Chen
Emerging evidences addressed an association between phosphate and muscle function. Because little attention was focused on this issue, the objective of our study was to explore the relationship of phosphate with muscle strength, dynapenia, and sarcopenia. From the National Health and Nutrition Examination Survey, a total of 7421 participants aged 20 years or older were included in our study with comprehensive examinations included anthropometric parameters, strength of the quadriceps muscle, and appendicular lean masses...
February 23, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29469024/association-between-body-composition-and-pulmonary-function-in-children-and-young-people-with-cystic-fibrosis
#20
Patrizia Calella, Giuliana Valerio, Matt Thomas, Helen McCabe, Jake Taylor, Malcolm Brodlie, Mario Siervo
OBJECTIVES: Body mass index (BMI) has significant limitations when assessing nutritional status in pediatric patients with cystic fibrosis (CF). We evaluated whether measurements of lean body mass (LBM) and fat mass (FM) are more sensitive nutritional parameters by testing their association with pulmonary function in adolescent patients with CF. METHODS: Sixty-nine male and female adolescents with CF were studied (age: 14.5 ± 2.3, BMI: 19.5 ± 2.3 kg/m2 )...
April 2018: Nutrition
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