keyword
MENU ▼
Read by QxMD icon Read
search

Lean model health

keyword
https://www.readbyqxmd.com/read/27902747/joint-profiling-of-mirnas-and-mrnas-reveals-mirna-mediated-gene-regulation-in-the-g%C3%A3-ttingen-minipig-obesity-model
#1
Caroline M Junker Mentzel, Ferhat Alkan, Helle Keinicke, Mette J Jacobsen, Jan Gorodkin, Merete Fredholm, Susanna Cirera
Obesity and its comorbidities are an increasing challenge for both affected individuals and health care systems, worldwide. In obese individuals, perturbation of expression of both protein-coding genes and microRNAs (miRNA) are seen in obesity-relevant tissues (i.e. adipose tissue, liver and skeletal muscle). miRNAs are small non-coding RNA molecules which have important regulatory roles in a wide range of biological processes, including obesity. Rodents are widely used animal models for human diseases including obesity...
2016: PloS One
https://www.readbyqxmd.com/read/27879495/fish-consumption-and-prostate-cancer-risk-and-mortality-in-a-danish-cohort-study
#2
Malene Outzen, Anne Tjønneland, Jane Christensen, Anja Olsen
Within the Danish 'Diet, Cancer and Health' cohort, we aimed to investigate the association between prediagnostic fish intake (total, lean, fatty) and (a) incidence of total and high-grade prostate cancer and (b) the risk of all-cause and prostate cancer-specific mortality among men with prostate cancer. Among 27 178 men, 1690 prostate cancer cases were identified through 2012. Of these, 1042 had a Gleason score of 7 or above and 498 had a Gleason score of 8 or above at the time of diagnosis; 364 died (n=228 from prostate cancer) during follow-up through 2013...
November 22, 2016: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/27813053/elevated-steroid-hormone-production-in-the-db-db-mouse-model-of-obesity-and-type-2-diabetes
#3
A Hofmann, M Peitzsch, C Brunssen, J Mittag, A Jannasch, A Frenzel, N F Brown, S M Weldon, G Eisenhofer, S R Bornstein, H Morawietz
Obesity and type 2 diabetes have become a major public health problem worldwide. Steroid hormone dysfunction appears to be linked to development of obesity and type 2 diabetes and correction of steroid abnormalities may offer new approaches to therapy. We therefore analyzed plasma steroids in 15-16 week old obese and diabetic db/db mice using liquid chromatography-tandem mass spectrometry. Lean db/+ served as controls. Db/db mice developed obesity, hyperglycemia, hyperleptinemia, and hyperlipidemia. Hepatic triglyceride storage was increased and adiponectin and pancreatic insulin were lowered...
November 3, 2016: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/27804237/association-between-pulse-pressure-and-body-mass-index-in-hypertensive-and-normotensive-populations-in-the-korea-national-health-and-nutrition-examination-survey-v-2010-2012
#4
Min Gyu Kang, Kye-Hwan Kim, Jin-Sin Koh, Jeong Rang Park, Seok-Jae Hwang, Jin-Yong Hwang, Jong Hwa Ahn, Jeong Yoon Jang, Young-Hoon Jeong, Choong Hwan Kwak, Hyun Woong Park
The authors conducted a national cross-sectional cohort study to evaluate the associations between pulse pressure (PP) and body mass index (BMI) and sex, according to blood pressure (BP) status. A total of 18 812 patients without a history of antihypertensive medication and cardiovascular disease were selected. There was good concordance between PP and the selected cardiovascular risk factors. PP increased with high BMI among patients with normal BP, but decreased with high BMI among patients with hypertension (HTN)...
November 2, 2016: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/27774916/substitution-of-meat-and-fish-with-vegetables-or-potatoes-and-risk-of-myocardial-infarction
#5
Anne M L Würtz, Mette D Hansen, Anne Tjønneland, Eric B Rimm, Erik B Schmidt, Kim Overvad, Marianne U Jakobsen
Red meat has been suggested to be adversely associated with risk of myocardial infarction (MI), whereas vegetable consumption has been found to be protective. The aim of this study was to investigate substitutions of red meat, poultry and fish with vegetables or potatoes for MI prevention. We followed up 29 142 women and 26 029 men in the Danish Diet, Cancer and Health study aged 50-64 years with no known history of MI at baseline. Diet was assessed by a validated 192-item FFQ at baseline. Adjusted Cox proportional hazard models were used to calculate hazard ratios (HR) and 95 % CI for MI associated with specified food substitutions of 150 g/week...
October 24, 2016: British Journal of Nutrition
https://www.readbyqxmd.com/read/27757172/trends-in-the-prevalence-of-self-reported-diabetes-in-brazilian-capital-cities-and-the-federal-district-2006-2014
#6
Betine Pinto Moehlecke Iser, Álvaro Vigo, Bruce Bartholow Duncan, Maria Inês Schmidt
BACKGROUND: Diabetes is increasing globally, particularly in low and middle income countries, posing a great challenge to health systems. Brazil is currently ranked 4th in the world in terms of the absolute number of persons with diabetes. Our aim was to analyze the trend in self-reported diabetes prevalence between 2006 and 2014 in Brazilian adults. METHODS: We used data from the national telephone survey-VIGITEL. Over 40,000 individuals from probabilistic sample of subjects ≥18 years old residing in 26 state capitals and the Federal District were interviewed per year in each location...
2016: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/27756900/synchronized-human-skeletal-myotubes-of-lean-obese-and-type-2-diabetic-patients-maintain-circadian-oscillation-of-clock-genes
#7
Jan Hansen, Silvie Timmers, Esther Moonen-Kornips, Helene Duez, Bart Staels, Matthijs K C Hesselink, Patrick Schrauwen
Cell and animal studies have demonstrated that circadian rhythm is governed by autonomous rhythmicity of clock genes. Although disturbances in circadian rhythm have been implicated in metabolic disease development, it remains unknown whether muscle circadian rhythm is altered in human models of type 2 diabetes. Here we used human primary myotubes (HPM) to investigate if rhythmicity of clock- and metabolic gene expression is altered in donors with obesity or type 2 diabetes compared to metabolically healthy donors...
October 19, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27737609/metabolic-characterization-of-overweight-and-obese-adults
#8
Katie R Hirsch, Abbie E Smith-Ryan, Malia N M Blue, Meredith G Mock, Eric T Trexler, Kristin S Ondrak
OBJECTIVES: Traditional evaluations of metabolic health may overlook underlying dysfunction in individuals who show no signs of insulin resistance or dyslipidemia. The purpose of this study was to characterize metabolic health in overweight and obese adults using traditional and non-traditional cardiometabolic variables. A secondary purpose was to evaluate differences between overweight/obese and male/female cohorts, respectively. METHODS: Forty-nine overweight and obese adults (Mean ± SD; Age=35...
October 13, 2016: Physician and Sportsmedicine
https://www.readbyqxmd.com/read/27718179/assessment-of-folate-status-in-obese-patients-should-we-measure-folate-in-serum-or-in-red-blood-cells
#9
Damien Denimal, Marie-Claude Brindisi, Stéphanie Lemaire, Laurence Duvillard
BACKGROUND: Recent studies revealed that obesity is associated with decreased serum but at the same time increased red blood cell (RBC) folate concentrations compared with lean subjects, thus casting doubt upon the agreement between serum and RBC folate measurements for assessing folate status. This work aimed to determine whether these two metrics lead to the same classification of folate status in obese patients. METHODS: RBC and serum folate concentrations were measured with a chemiluminescent immunoassay in 263 adults with body mass index ≥30 kg/m(2) and without previous bariatric surgery...
October 8, 2016: Obesity Surgery
https://www.readbyqxmd.com/read/27717738/influence-of-relative-strength-on-functional-independence-of-patients-with-spinal-cord-injury
#10
Frederico Ribeiro Neto, Patrícia Guanais, Guilherme H Lopes, Elisa Dornelas, Daniela de Campos Barbetta, Alessandra C B Coutinho, Carlos Wellington Gonçalves, Rodrigo Rodrigues Gomes Costa
OBJECTIVE: The study aimed to investigate the influence of strength values and fat mass on functional independence of men with different spinal cord injury levels (SCI). DESIGN: Cross-sectional study; Setting: SARAH Rehabilitation Hospital Network - Brasilia, Brazil. PARTICIPANTS: Forty-five men with SCI were enrolled in the study. INTERVENTIONS: Subjects were assessed in functional independence scales, one maximum repetition test (1RM) and body composition to detect absolute and relative strength: 1RM divided by body mass (BM) and lean body mass (LBM)...
October 4, 2016: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/27709979/risk-factors-that-predict-future-onset-of-each-dsm-5-eating-disorder-predictive-specificity-in-high-risk-adolescent-females
#11
Eric Stice, Jeff M Gau, Paul Rohde, Heather Shaw
Because no single report has examined risk factors that predict future onset each type of eating disorder and core symptom dimensions that crosscut disorders, we addressed these aims to advance knowledge regarding risk factor specificity. Data from 3 prevention trials that targeted young women with body dissatisfaction (N = 1,272; Mage = 18.5, SD = 4.2) and collected annual diagnostic interview data over 3-year follow-up were combined to identify predictors of subthreshold/threshold anorexia nervosa (AN), bulimia nervosa (BN), binge eating disorder (BED), and purging disorder (PD)...
October 6, 2016: Journal of Abnormal Psychology
https://www.readbyqxmd.com/read/27709227/is-meeting-the-recommended-dietary-allowance-rda-for-protein-related-to-body-composition-among-older-adults-results-from-the-cardiovascular-health-of-seniors-and-built-environment-study
#12
J M Beasley, A L Deierlein, K B Morland, E C Granieri, A Spark
OBJECTIVE: Studies suggest protein intake may be associated with lower body weight, but protein has also been associated with preservation of lean body mass. Understanding the role of protein in maintaining health for older adults is important for disease prevention among this population. DESIGN: Cross-sectional study of the relationship of dietary protein on body composition. SETTING: New York City community centers. PARTICIPANTS: 1,011 Black, White, and Latino urban men and women 60-99 years of age...
2016: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/27702621/relationships-between-anthropometric-measurements-and-intraocular-pressure-the-korea-national-health-and-nutrition-examination-survey
#13
Hyun Tae Kim, Joon Mo Kim, Jung Hoon Kim, Jae Hyuck Lee, Mi Yeon Lee, Jae Yeun Lee, Yu Sam Won, Ki Ho Park, Hyun Seok Kwon
PURPOSE: To evaluate the relationship between intraocular pressure (IOP) and various anthropometric measures. DESIGN: A population-based cross-sectional study. METHODS: A total of 5008 participants, 2080 men and 2928 women ≥19 years of age were included from the Korea National Health and Nutrition Examination Survey V database, focusing on the years 2010 and 2011. We selected IOP in the right eye of a normal healthy population as the outcome variable of our study...
January 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/27652290/cats-in-positive-energy-balance-have-lower-rates-of-adipose-gain-when-fed-diets-containing-188-versus-121%C3%A2-ppm-l-carnitine
#14
M A Gooding, D L Minikhiem, A K Shoveller
L-carnitine (LC) is included in select adult feline diets for weight management. This study investigated whether feeding adult cats with diets containing either 188 ppm of LC (LC188) or 121 ppm of LC (LC121) and feeding them 120% of maintenance energy requirement (MER) resulted in differences in total energy expenditure (EE), metabolic fuel selection, BW, body composition, and behavior. Cats (n = 20, 4 ± 1.2 yrs) were stratified for BCS and randomly assigned to one of two dietary treatments and fed for 16 weeks...
2016: TheScientificWorldJournal
https://www.readbyqxmd.com/read/27647791/the-frontal-assessment-battery-normative-performance-in-a-large-sample-of-older-community-dwelling-hospital-outpatient-or-general-practitioner-attenders
#15
Robert F Coen, Kevin McCarroll, Miriam Casey, Helene McNulty, Eamon Laird, Anne M Molloy, M Ward, J J Strain, Leane Hoey, Catherine Hughes, Conal J Cunningham
BACKGROUND: The Frontal Assessment Battery (FAB) is a short battery designed to assess frontal executive functioning, but data for interpretation of performance are limited. OBJECTIVES: The Trinity, Ulster, Department of Agriculture (TUDA) study provided the opportunity to derive performance data from a large sample of community-dwelling hospital outpatient or general practitioner (GP) attenders. METHODS: Normative analysis based on 2508 TUDA participants meeting these criteria: Mini-Mental State Examination (MMSE) >26/30, not depressed (Center for Epidemiologic Studies Depression <16) or anxious (Hospital Anxiety and Depression Scale <8), no history of stroke, or transient ischemic attack...
September 19, 2016: Journal of Geriatric Psychiatry and Neurology
https://www.readbyqxmd.com/read/27635625/do-anthropometric-measures-accurately-reflect-body-composition-in-preterm-infants
#16
S E Ramel, L Zhang, S Misra, C G Anderson, E W Demerath
BACKGROUND: Recent literature suggests that neonatal adiposity is predictive of later metabolic health, while neonatal lean mass is predictive of later cognitive function amongst preterm infants. Anthropometric indices that accurately reflect neonatal body composition could improve clinical care and aid future research, but their validity has not been systematically tested in preterm infants. OBJECTIVE: To determine the weight/length indices that best reflect neonatal body composition in preterm infants...
September 16, 2016: Pediatric Obesity
https://www.readbyqxmd.com/read/27616073/unravelling-the-relationship-between-body-mass-index-and-polychlorinated-biphenyl-concentrations-using-a-mechanistic-model
#17
Stephen A Wood, Feng Xu, James M Armitage, Frank Wania
Human biomonitoring (HBM) often reveals statistical associations between persistent organic pollutant (POP) concentrations and body mass index (BMI). Both negative and positive associations have been observed, which has been hypothesized to reflect variable toxicokinetics in lean and obese individuals during times of increasing and decreasing exposure. We examined this hypothesis and assessed the influence of the obesity epidemic on time trends in human exposure to polychlorinated biphenyls (PCB) at the population level using a mechanistic modeling approach and data from the National Health and Nutrition Examination Survey (NHANES) 1999-2004...
September 20, 2016: Environmental Science & Technology
https://www.readbyqxmd.com/read/27605320/pharmacist-prescribing-within-an-integrated-health-system-in-washington
#18
Roger Woolf, Amanda Locke, Catherine Potts
PURPOSE: Pharmacist prescribing as part of a collaborative drug therapy agreement (CDTA) within an integrated health system in Washington is described. SUMMARY: Virginia Mason Medical Center (VMMC) in Seattle, Washington, uses a team-based care model with broad-based CDTAs to provide quality patient care. The majority of patients are referred to the pharmacist after a diagnosis has been made and a clinical care plan has been started. The pharmacist manages the patient's care within his or her scope of practice as defined by state laws and further detailed by VMMC internal protocols...
September 15, 2016: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/27583789/maternal-obesity-in-pregnancy-developmentally-programs-adipose-tissue-inflammation-in-young-lean-male-mice-offspring
#19
Maria Z Alfaradhi, Laura C Kusinski, Denise S Fernandez-Twinn, Lucas C Pantaleão, Sarah K Carr, David Ferland-McCollough, Giles S H Yeo, Martin Bushell, Susan E Ozanne
Obesity during pregnancy has a long-term effect on the health of the offspring including risk of developing the metabolic syndrome. Using a mouse model of maternal diet-induced obesity, we employed a genome-wide approach to investigate the microRNA (miRNA) and miRNA transcription profile in adipose tissue to understand mechanisms through which this occurs. Male offspring of diet-induced obese mothers, fed a control diet from weaning, showed no differences in body weight or adiposity at 8 weeks of age. However, offspring from the obese dams had up-regulated cytokine (Tnfα; P < ...
November 2016: Endocrinology
https://www.readbyqxmd.com/read/27573855/association-between-the-ratio-of-triglyceride-to-high-density-lipoprotein-cholesterol-and-incident-type-2-diabetes-in-singapore-chinese-men-and-women
#20
Ye-Li Wang, Woon-Puay Koh, Mohammad Talaei, Jian-Min Yuan, An Pan
BACKGROUND: Increased triglycerides (TG) and decreased high-density lipoprotein cholesterol (HDL-C) are risk factors for type 2 diabetes (T2D). The relationship between TG:HDL-C ratio and T2D risk is not clear, and it is not known whether the association is modified by gender, body mass index, or fasting status. This study examined the relationship between TG:HDL-C ratio and risk of incident T2D, and the predictive ability of the ratio on top of other diabetes risk factors. METHODS: Blood biomarkers were determined in 571 T2D cases and 571 controls nested within a prospective, population-based cohort study, the Singapore Chinese Health Study...
August 30, 2016: Journal of Diabetes
keyword
keyword
91361
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"