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https://www.readbyqxmd.com/read/28636087/extended-inferior-antrostomy-for-maxillary-sinus-surgery
#1
Justin Michel, Thomas Radulesco, Martin Penicaud, Patrick Dessi
Functional endoscopic sinus surgery (FESS) has considerably evolved over the past 20 years while minimally-invasive surgery also applies to sinus procedures. Development of new technologies combined with better knowledge of risks has allowed surgeons to achieve improved results in their FESS indications. One of the most difficult areas to visualize using the exclusive endoscopic approach is still the anterior recess of the maxillary sinus. Hence, external approaches, such as the Caldwell-Luc procedure, are still used by many surgeons to ensure visual control of this area in diseases such as fungal balls, mucoceles, inverted papilloma and other tumors...
June 21, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28634778/how-are-socio-demographic-and-psycho-social-factors-associated-with-the-prevalence-and-chronicity-of-severe-pain-in-14%C3%A2-different-body-sites-a%C3%A2-cross-sectional-population-based-survey
#2
Thomas Ernst Dorner, Katharina Viktoria Stein, Julia Hahne, Florian Wepner, Martin Friedrich, Ellenor Mittendorfer-Rutz
BACKGROUND: Severe pain and chronic pain have a high impact on individuals and society. Body location of pain is important with regard to perception, articulation, and underlying biological, mental or social causes of pain. METHODS: A cross-sectional survey was performed in the general Austrian population with 15,474 personally interviewed subjects aged 15 years and older. RESULTS: The 1‑year period prevalence of severe pain in any body site was 38...
June 20, 2017: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/28634240/leucine-biosynthesis-is-involved-in-regulating-high-lipid-accumulation-in-yarrowia-lipolytica
#3
Eduard J Kerkhoven, Young-Mo Kim, Siwei Wei, Carrie D Nicora, Thomas L Fillmore, Samuel O Purvine, Bobbie-Jo Webb-Robertson, Richard D Smith, Scott E Baker, Thomas O Metz, Jens Nielsen
The yeast Yarrowia lipolytica is a potent accumulator of lipids, and lipogenesis in this organism can be influenced by a variety of factors, such as genetics and environmental conditions. Using a multifactorial study, we elucidated the effects of both genetic and environmental factors on regulation of lipogenesis in Y. lipolytica and identified how two opposite regulatory states both result in lipid accumulation. This study involved comparison of a strain overexpressing diacylglycerol acyltransferase (DGA1) with a control strain grown under either nitrogen or carbon limitation conditions...
June 20, 2017: MBio
https://www.readbyqxmd.com/read/28634237/the-pseudomonas-aeruginosa-psl-polysaccharide-is-a-social-but-noncheatable-trait-in-biofilms
#4
Yasuhiko Irie, Aled E L Roberts, Kasper N Kragh, Vernita D Gordon, Jaime Hutchison, Rosalind J Allen, Gavin Melaugh, Thomas Bjarnsholt, Stuart A West, Stephen P Diggle
Extracellular polysaccharides are compounds secreted by microorganisms into the surrounding environment, and they are important for surface attachment and maintaining structural integrity within biofilms. The social nature of many extracellular polysaccharides remains unclear, and it has been suggested that they could function as either cooperative public goods or as traits that provide a competitive advantage. Here, we empirically tested the cooperative nature of the PSL polysaccharide, which is crucial for the formation of biofilms in Pseudomonas aeruginosa We show that (i) PSL is not metabolically costly to produce; (ii) PSL provides population-level benefits in biofilms, for both growth and antibiotic tolerance; (iii) the benefits of PSL production are social and are shared with other cells; (iv) the benefits of PSL production appear to be preferentially directed toward cells which produce PSL; (v) cells which do not produce PSL are unable to successfully exploit cells which produce PSL...
June 20, 2017: MBio
https://www.readbyqxmd.com/read/28632140/thermal-stability-and-rheological-properties-of-the-non-stick-caf1-biomaterial
#5
Yakup Ulusu, Gema Dura, Helen Waller, Matthew Benning, David Fulton, Jeremy Lakey, Daniel Thomas Peters
The ability to culture cells in three dimensions has many applications, from drug discovery to wound healing. 3D cell culture methods often require appropriate scaffolds that mimic the cellular environments of different tissue types. The choice of material from which these scaffolds are made is of paramount importance, as its properties will define the manner in which cells interact with the scaffold. Caf1 is a protein polymer that is secreted from its host organism, Yersinia pestis, to enable escape from phagocytosis...
June 20, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28630725/endoscopic-repair-of-hip-abductor-tears-outcomes-with-two-year-follow-up
#6
J W Thomas Byrd, Kay S Jones
Abductor lesions are increasingly recognized as a source of recalcitrant laterally based hip pain and dysfunction. There is a growing body of evidence that many of these may be amenable to endoscopic repair. To report the demographic data and outcomes of endoscopic hip abductor repair. Twelve patients underwent endoscopic abductor repair with 2-year follow-up. These patients were prospectively assessed with modified Harris hip and iHOT scores. The indications for surgery were clinical and MRI findings of symptomatic abductor tears that had failed conservative treatment...
January 2017: Journal of Hip Preservation Surgery
https://www.readbyqxmd.com/read/28630651/improving-antiretroviral-therapy-adherence-in-resource-limited-settings-at-scale-a-discussion-of-interventions-and-recommendations
#7
Jessica E Haberer, Lora Sabin, K Rivet Amico, Catherine Orrell, Omar Galárraga, Alexander C Tsai, Rachel C Vreeman, Ira Wilson, Nadia A Sam-Agudu, Terrence F Blaschke, Bernard Vrijens, Claude A Mellins, Robert H Remien, Sheri D Weiser, Elizabeth Lowenthal, Michael J Stirratt, Papa Salif Sow, Bruce Thomas, Nathan Ford, Edward Mills, Richard Lester, Jean B Nachega, Bosco Mwebesa Bwana, Fred Ssewamala, Lawrence Mbuagbaw, Paula Munderi, Elvin Geng, David R Bangsberg
Introduction: Successful population-level antiretroviral therapy (ART) adherence will be necessary to realize both the clinical and prevention benefits of antiretroviral scale-up and, ultimately, the end of AIDS. Although many people living with HIV are adhering well, others struggle and most are likely to experience challenges in adherence that may threaten virologic suppression at some point during lifelong therapy. Despite the importance of ART adherence, supportive interventions have generally not been implemented at scale...
2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28630595/qsar-models-of-human-data-can-enrich-or-replace-llna-testing-for-human-skin-sensitization
#8
Vinicius M Alves, Stephen J Capuzzi, Eugene Muratov, Rodolpho C Braga, Thomas Thornton, Denis Fourches, Judy Strickland, Nicole Kleinstreuer, Carolina H Andrade, Alexander Tropsha
Skin sensitization is a major environmental and occupational health hazard. Although many chemicals have been evaluated in humans, there have been no efforts to model these data to date. We have compiled, curated, analyzed, and compared the available human and LLNA data. Using these data, we have developed reliable computational models and applied them for virtual screening of chemical libraries to identify putative skin sensitizers. The overall concordance between murine LLNA and human skin sensitization responses for a set of 135 unique chemicals was low (R = 28-43%), although several chemical classes had high concordance...
December 21, 2016: Green Chemistry: An International Journal and Green Chemistry Resource: GC
https://www.readbyqxmd.com/read/28630467/computational-method-allowing-hydrogen-deuterium-exchange-mass-spectrometry-at-single-amide-resolution
#9
Chris Gessner, Wieland Steinchen, Sabrina Bédard, John J Skinner, Virgil L Woods, Thomas J Walsh, Gert Bange, Dionysios P Pantazatos
Hydrogen-deuterium exchange (HDX) coupled with mass spectrometry (HDXMS) is a rapid and effective method for localizing and determining protein stability and dynamics. Localization is routinely limited to a peptide resolution of 5 to 20 amino acid residues. HDXMS data can contain information beyond that needed for defining protein stability at single amide resolution. Here we present a method for extracting this information from an HDX dataset to generate a HDXMS protein stability fingerprint. High resolution (HR)-HDXMS was applied to the analysis of a model protein of a spectrin tandem repeat that exemplified an intuitive stability profile based on the linkage of two triple helical repeats connected by a helical linker...
June 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28630444/modelling-the-effects-of-global-climate-change-on-chikungunya-transmission-in-the-21-st-century
#10
Nils B Tjaden, Jonathan E Suk, Dominik Fischer, Stephanie M Thomas, Carl Beierkuhnlein, Jan C Semenza
The arrival and rapid spread of the mosquito-borne viral disease Chikungunya across the Americas is one of the most significant public health developments of recent years, preceding and mirroring the subsequent spread of Zika. Globalization in trade and travel can lead to the importation of these viruses, but climatic conditions strongly affect the efficiency of transmission in local settings. In order to direct preparedness for future outbreaks, it is necessary to anticipate global regions that could become suitable for Chikungunya transmission...
June 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28628296/enhanced-antibacterial-properties-of-self-assembling-peptide-amphiphiles-functionalized-with-heparin-binding-cardin-motifs
#11
Run Chang, Keerthana Subramanian, Mian Wang, Thomas J Webster
The emergence of antibiotic resistance in bacteria has caused many healthcare problems and social burdens. Herein, we designed and studied self-assembled peptide amphiphiles (PAs) functionalized with a heparin-binding Cardin-motif peptide (sequence (AKKARK)2) to combat bacteria drug resistance. These amphiphilic Cardin antimicrobial peptides (ACA-PAs) self-assembled into nanorods (7-10 nm in diameter) with the cationic Cardin-motif peptide exposed on the surface. The ACA nanorods formed above the critical micelle concentration (CMC) of 45 µM into a β-sheet secondary structure...
June 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28626069/how-many-deaths-from-colorectal-cancer-can-be-prevented-by-2030-a-scenario-based-quantification-of-risk-factor-modification-screening-and-treatment-in-norway
#12
Katrine Damgaard Skyrud, Tor Age Myklebust, Freddie Bray, Morten Tandberg Eriksen, Thomas de Lange, Inger Kristin Larsen, Bjørn Møller
BACKGROUND: Colorectal cancer (CRC) mortality can be reduced through risk factor modification (adherence to lifestyle recommendations), screening, and improved treatment. This study estimated the potential of these three strategies to modify CRC mortality rates in Norway. METHODS: The potential reduction in CRC mortality due to risk factor modification was estimated using the software Prevent, assuming that 50% of the population in Norway-who do not adhere to the various recommendations concerning prevention of smoking, physical activity, body weight, and intake of alcohol, red/processed meat, and fiber-started to follow the recommendations...
June 16, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28626000/baiap3-a-c2-domain-containing-munc13-protein-controls-the-fate-of-dense-core-vesicles-in-neuroendocrine-cells
#13
Xingmin Zhang, Shan Jiang, Kelly A Mitok, Lingjun Li, Alan D Attie, Thomas F J Martin
Dense-core vesicle (DCV) exocytosis is a SNARE (soluble N-ethylmaleimide-sensitive fusion attachment protein receptor)-dependent anterograde trafficking pathway that requires multiple proteins for regulation. Several C2 domain-containing proteins are known to regulate Ca(2+)-dependent DCV exocytosis in neuroendocrine cells. In this study, we identified others by screening all (∼139) human C2 domain-containing proteins by RNA interference in neuroendocrine cells. 40 genes were identified, including several encoding proteins with known roles (CAPS [calcium-dependent activator protein for secretion 1], Munc13-2, RIM1, and SYT10) and many with unknown roles...
June 16, 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/28623847/toxicity-after-post-prostatectomy-image-guided-intensity-modulated-radiotherapy-using-australian-guidelines
#14
Stephen Chin, Noel J Aherne, Andrew Last, Hassan Assareh, Thomas P Shakespeare
INTRODUCTION: We evaluated single institution toxicity outcomes after post-prostatectomy radiotherapy (PPRT) via image-guided intensity-modulated radiation therapy (IG-IMRT) with implanted fiducial markers following national eviQ guidelines, for which late toxicity outcomes have not been published. METHODS: Prospectively collected toxicity data were retrospectively reviewed for 293 men who underwent 64-66 Gy IG-IMRT to the prostate bed between 2007 and 2015. RESULTS: Median follow-up after PPRT was 39 months...
June 17, 2017: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/28623722/recent-advances-in-synthetic-biology-for-engineering-isoprenoid-production-in-yeast
#15
REVIEW
Claudia E Vickers, Thomas C Williams, Bingyin Peng, Joel Cherry
Isoprenoids (terpenes/terpenoids) have many useful industrial applications, but are often not produced at industrially viable level in their natural sources. Synthetic biology approaches have been used extensively to reconstruct metabolic pathways in tractable microbial hosts such as yeast and re-engineer pathways and networks to increase yields. Here we review recent advances in this field, focusing on central carbon metabolism engineering to increase precursor supply, re-directing carbon flux for production of C10, C15, or C20 isoprenoids, and chemical decoration of high value diterpenoids (C20)...
June 14, 2017: Current Opinion in Chemical Biology
https://www.readbyqxmd.com/read/28623024/functional-diversity-of-aquatic-ciliates
#16
REVIEW
Thomas Weisse
This paper first reviews the concept of functional diversity in general terms and then applies it to free-living aquatic ciliates. Ciliates are extremely versatile organisms and display an enormous functional diversity as key elements of pelagic food webs, acting as predators of bacteria, algae, other protists and even some metazoans. Planktonic ciliates are important food for zooplankton, and mixotrophic and functionally autotrophic species may significantly contribute to primary production in the ocean and in lakes...
April 13, 2017: European Journal of Protistology
https://www.readbyqxmd.com/read/28622459/structural-plasticity-among-glutathione-transferase-phi-members-natural-combination-of-catalytic-residues-confers-dual-biochemical-activities
#17
Henri Pégeot, Sandrine Mathiot, Thomas Perrot, Frédéric Gense, Arnaud Hecker, Claude Didierjean, Nicolas Rouhier
The glutathione transferase (GST) gene family is divided into fourteen classes in photosynthetic organisms. Among them, the Phi class (GSTF) is composed of a large number of genes that are often induced in response to environmental constraints due to their ability to detoxify xenobiotics, to their peroxidase activity and to their involvement in the biosynthesis and/or transport of secondary metabolites. However, the exact functions of GSTFs from many plants including Populus trichocarpa are unknown. Here, following GSTF1 characterization, we have performed a comparative analysis of the seven other GSTFs found in poplar by systematically evaluating the biochemical and enzymatic properties of the corresponding recombinant proteins and of variants mutated for active site residues and by determining the three-dimensional structures of several representatives...
June 16, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28622397/looking-for-the-most-suitable-orthotopic-retinoblastoma-mouse-model-in-order-to-characterize-the-tumoral-development
#18
Stéphanie Lemaitre, Florent Poyer, Sergio Marco, Paul Fréneaux, François Doz, Isabelle Aerts, Laurence Desjardins, Nathalie Cassoux, Carole D Thomas
Purpose: Because retinoblastoma therapies have many adverse effects, new approaches must be developed and evaluated on animal models. We describe orthotopic xenograft models of retinoblastoma using different strains of mice, suitable for this purpose. Methods: Human retinoblastoma tumors were established on immunodeficient mice by subcutaneous engraftment of tumors from enucleated eyes. The orthotopic model was obtained by subretinal injections of suspension cells into the right eye of immunodeficient (Swiss-nude, severe combined immunodeficiency [SCID]) and immunocompetent mice (C57BL/6N, B6Albino)...
June 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28622346/flavivirus-and-filovirus-evoprinters-new-alignment-tools-for-the-comparative-analysis-of-viral-evolution
#19
Thomas Brody, Amarendra S Yavatkar, Dong Sun Park, Alexander Kuzin, Jermaine Ross, Ward F Odenwald
BACKGROUND: Flavivirus and Filovirus infections are serious epidemic threats to human populations. Multi-genome comparative analysis of these evolving pathogens affords a view of their essential, conserved sequence elements as well as progressive evolutionary changes. While phylogenetic analysis has yielded important insights, the growing number of available genomic sequences makes comparisons between hundreds of viral strains challenging. We report here a new approach for the comparative analysis of these hemorrhagic fever viruses that can superimpose an unlimited number of one-on-one alignments to identify important features within genomes of interest...
June 16, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28620985/development-of-a-patient-and-institutional-based-model-for-estimation-of-operative-times-for-robot-assisted-radical-cystectomy-results-from-the-international-robotic-cystectomy-consortium
#20
Ahmed A Hussein, Paul R May, Youssef E Ahmed, Matthias Saar, Carl J Wijburg, Lee Richstone, Andrew Wagner, Timothy Wilson, Bertram Yuh, Joan Palou Redorta, Prokar Dasgupta, Omar Kawa, Mohammad Shamim Khan, Mani Menon, James O Peabody, Abolfazl Hosseini, Franco Gaboardi, Giovannalberto Pini, Francis Schanne, Alexandre Mottrie, Koon-Ho Rha, Ashok Hemal, Michael Stockle, John Kelly, Wei Shen Tan, Thomas J Maatman, Vassilis Poulakis, Jihad Kaouk, Abdullah Erdem Canda, Mevlana Derya Balbay, Peter Wiklund, Khurshid A Guru
OBJECTIVES: To design a methodology to predict operative times for robot-assisted radical cystectomy (RARC) based on variation in institutional, patient and disease characteristic to help in operating room scheduling and quality control. METHODS: The model included preoperative variables and therefore can be used for prediction of surgical times: institutional volume, age, gender, BMI, ASA Score, history of prior surgery and radiation, clinical stage, neoadjuvant chemotherapy, type, technique of diversion and the extent of lymph node dissection...
June 16, 2017: BJU International
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