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https://www.readbyqxmd.com/read/27920666/circuits-regulating-pleasure-and-happiness-the-evolution-of-the-amygdalar-hippocampal-habenular-connectivity-in-vertebrates
#1
Anton J M Loonen, Svetlana A Ivanova
Appetitive-searching (reward-seeking) and distress-avoiding (misery-fleeing) behavior are essential for all free moving animals to stay alive and to have offspring. Therefore, even the oldest ocean-dwelling animal creatures, living about 560 million years ago and human ancestors, must have been capable of generating these behaviors. The current article describes the evolution of the forebrain with special reference to the development of the misery-fleeing system. Although, the earliest vertebrate ancestor already possessed a dorsal pallium, which corresponds to the human neocortex, the structure and function of the neocortex was acquired quite recently within the mammalian evolutionary line...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27917104/thirty-eight-year-follow-up-of-two-sibling-lipoid-congenital-adrenal-hyperplasia-patients-due-to-homozygous-steroidogenic-acute-regulatory-stard1-protein-mutation-molecular-structure-and-modeling-of-the-stard1-l275p-mutation
#2
Khalil Khoury, Elie Barbar, Youssef Ainmelk, Annie Ouellet, Pierre Lavigne, Jean-Guy LeHoux
Objective: Review the impact of StAR (STARD1) mutations on steroidogenesis and fertility in LCAH patients. Examine the endocrine mechanisms underlying the pathology of the disorder and the appropriate therapy for promoting fertility and pregnancies. Design: Published data in the literature and a detailed 38-year follow-up of two sibling LCAH patients. Molecular structure and modeling of the STARD1 L275P mutation. Setting: University hospital. Patients: Patient A (46,XY female phenotype) and patient B (46,XX female) with LCAH bearing the L275P mutation in STARD1...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27893550/application-of-dexamethasone-in-the-masseter-muscle-during-the-surgical-removal-of-lower-third-molars
#3
Alípio Miguel Rocha-Neto, Emerson Filipe de Carvalho Nogueira, Patrícia Mendonça Borba, José Rodrigues Laureano-Filho, Belmiro Cavalcanti do Egito Vasconcelos
PURPOSE: The aim of the present study was to analyze the effect of the application of dexamethasone in the masseter muscle during third molar surgery. METHODS: This randomized, clinical trial used dependent samples and the split-mouth method. A sample of 30 patients, with impacted or semi-impacted third molars, as well as vertical and mesioangular positions of a similar surgical difficulty (on both sides), was subjected to 2 operations: an experimental operation and a control procedure, with a 30-day wash-out...
November 23, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27892784/management-and-outcome-challenges-in-newborns-with-gastroschisis-a-6-year-retrospective-french-study
#4
B Tosello, M Zahed, F Guimond, K Baumstarck, A Faure, F Michel, O Claris, C Gire, I Berakdar, J Massardier, C D'Ercole, T Merrot
OBJECTIVE: to identify the gestational age (GA) at which risk of mortality and severe outcome was minimized comparing preterm delivery and expectant management. METHODS: Retrospective study performed between 2009 to 2014 of newborns with gastroschisis in three large French level III neonatal intensive care units. Each department followed two distinct strategies: elective delivery at 35 weeks GA and, a delayed approach. RESULTS: We included 69 gastroschisis cases...
November 28, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27879189/gemcitabine-induced-hemolytic-uremic-syndrome-treated-with-eculizumab-or-plasmapheresis-two-case-reports%C3%A2
#5
María Esperanza López Rubio, Raquel Rodado Martínez, María Luisa Illescas, Encarnación Mateo Bosch, Mercedes Martínez Díaz, Lourdes de la Vara Inesta, Basilio Cabezuelo, María Elisa Morales Albuja, Eladio Lucas Guillén, Luisa Jimeno García
BACKGROUND: Drug-induced hemolytic-uremic syndrome (HUS) has shown good response to eculizumab (ECU). We present 2 cases of patients with gemcitabine-induced HUS (GEM-HUS), one of whom was treated with ECU and the other with conventional treatment. Patient 1: A 74-year-old male with resected adenocarcinoma of the pancreas started adjuvant treatment with GEM, but after 5 months GEM was discontinued due to acute kidney injury and severe hypertension. Laboratory analyses identified microangiopathic hemolytic anemia (MHA) and thrombocytopenia...
November 23, 2016: Clinical Nephrology
https://www.readbyqxmd.com/read/27825644/-variability-and-suitability-of-anti-asmathic-treatment-in-pediatric-primary-health-care
#6
Cristina Suárez-Castañón, Gracia Modroño-Riaño, Gonzalo Solís-Sánchez
OBJECTIVE: To analyse the use patterns and the characteristics of anti-asmathic prescriptions in pediatric primary health care. DESIGN: Observational and retrospective study. LOCATION: Pediatric primary health care, Asturias, Spain. PARTICIPANTS: Drug prescriptions in respiratory diseases in children (<14years old) during 2011. PRINCIPAL MEASUREMENTS: Data obtained from the billing database of the Regional Health Service of Asturias and analysed by sanitary district and primary health centres, calculating the number of DDD/1...
November 5, 2016: Atencion Primaria
https://www.readbyqxmd.com/read/27785100/current-advances-in-biomarkers-for-targeted-therapy-in-triple-negative-breast-cancer
#7
REVIEW
Brett Fleisher, Charlotte Clarke, Sihem Ait-Oudhia
Triple-negative breast cancer (TNBC) is a complex heterogeneous disease characterized by the absence of three hallmark receptors: human epidermal growth factor receptor 2, estrogen receptor, and progesterone receptor. Compared to other breast cancer subtypes, TNBC is more aggressive, has a higher prevalence in African-Americans, and more frequently affects younger patients. Currently, TNBC lacks clinically accepted targets for tailored therapy, warranting the need for candidate biomarkers. BiomarkerBase, an online platform used to find biomarkers reported in clinical trials, was utilized to screen all potential biomarkers for TNBC and select only the ones registered in completed TNBC trials through clinicaltrials...
2016: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/27759787/management-of-acute-severe-ulcerative-colitis-a-clinical-update
#8
Carlos Walter Sobrado, Lucas Faraco Sobrado
Introduction: Acute severe colitis is a potentially lethal medical emergency and, even today, its treatment remains a challenge for clinicians and surgeons. Intravenous corticoid therapy, which was introduced into the therapeutic arsenal in the 1950s, continues to be the first-line treatment and, for patients who are refractory to this, the rescue therapy may consist of clinical measures or emergency colectomy. Objective: To evaluate the indications for and results from drug rescue therapy (cyclosporine, infliximab and tacrolimus), and to suggest a practical guide for clinical approaches...
July 2016: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
https://www.readbyqxmd.com/read/27754177/sy-15-4-role-of-histone-deacetylases-in-regulating-endothelial-and-vascular-function
#9
InKyeom Kim
Histone deacetylases (HDACs) act as co-repressors in gene transcription by erasing the acetylation of histones, resulting in epigenetic gene silencing. Recent studies revealed that HDAC inhibitors attenuated blood pressure of several hypertensive animal models such as spontaneously hypertensive rats, hyperaldosteronism rats, angiotensin II-induced hypertensive rats and pulmonary hypertensive rats. Unexpectedly, microarray studies uncovered that administration of HDAC inhibitors decreased expression of some genes for example extracellular matrix proteins, oxidative stress-related proteins, cytokines, chemokines and ion transporters, mostly targets of corticoid receptors...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27737327/the-coexistence-of-hypercalcemia-and-hypoglycemia-in-a-patient-with-a-renal-tumor-and-b-cell-lymphoma
#10
Jimena Soutelo, Sofía Moldes, Cielo Frisone, Laura Salvá, Cecilia Agostinis, Gabriel Faraj
Paraneoplastic syndromes are a heterogeneous group of malignant diseases caused by events which involve endocrine, immune and metabolic aspects and whose symptoms vary according to the substance produced and the primary tumor. Hypercalcemia is a frequent complication in cancer patients. Prognosis of cancer patients with hypercalcemia is usually poor. A factor called parathyroid hormone related peptide, whose actions are similar to those of the parathyroid hormone, is thought to be the most common cause of malignancy associated hypercalcemia...
October 10, 2016: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27716396/glucocorticoid-induced-leucine-zipper-gilz-is-involved-in-glucocorticoid-induced-and-mineralocorticoid-induced-leptin-production-by-osteoarthritis-synovial-fibroblasts
#11
Olivier Malaise, Biserka Relic, Edith Charlier, Mustapha Zeddou, Sophie Neuville, Céline Deroyer, Philippe Gillet, Edouard Louis, Michel G Malaise, Dominique de Seny
BACKGROUND: Glucocorticoid-induced leucine zipper (GILZ) is a mediator of the anti-inflammatory activities of glucocorticoids. However, GILZ deletion does not impair the anti-inflammatory activities of exogenous glucocorticoids in mice arthritis models and GILZ could also mediate some glucocorticoid-related adverse events. Osteoarthritis (OA) is a metabolic disorder that is partly attributed to adipokines such as leptin, and we previously observed that glucocorticoids induced leptin secretion in OA synovial fibroblasts...
October 4, 2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27643134/sy-15-4-role-of-histone-deacetylases-in-regulating-endothelial-and-vascular-function
#12
InKyeom Kim
Histone deacetylases (HDACs) act as co-repressors in gene transcription by erasing the acetylation of histones, resulting in epigenetic gene silencing. Recent studies revealed that HDAC inhibitors attenuated blood pressure of several hypertensive animal models such as spontaneously hypertensive rats, hyperaldosteronism rats, angiotensin II-induced hypertensive rats and pulmonary hypertensive rats. Unexpectedly, microarray studies uncovered that administration of HDAC inhibitors decreased expression of some genes for example extracellular matrix proteins, oxidative stress-related proteins, cytokines, chemokines and ion transporters, mostly targets of corticoid receptors...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27593925/sensitization-of-retinoids-and-corticoids-to-epigenetic-drugs-in-myc-activated-lung-cancers-by-antitumor-reprogramming
#13
O A Romero, S Verdura, M Torres-Diz, A Gomez, S Moran, E Condom, M Esteller, A Villanueva, M Sanchez-Cespedes
Components of the SWI/SNF chromatin remodeling complex, including BRG1 (also SMARCA4), are inactivated in cancer. Among other functions, SWI/SNF orchestrates the response to retinoid acid (RA) and glucocorticoids (GC) involving downregulation of MYC. The epigenetic drugs SAHA and azacytidine, as well as RA and GC, are currently being used to treat some malignancies but their therapeutic potential in lung cancer is not well established. Here we aimed to determine the possible therapeutic effects of azacytidine and SAHA (A/S) alone or in combination with GC plus RA (GC/RA) in lung cancers with either BRG1 inactivation or MYC amplification...
September 5, 2016: Oncogene
https://www.readbyqxmd.com/read/27578200/evaluation-of-insulin-like-growth-factor-1-total-thyroxine-feline-pancreas-specific-lipase-and-urinary-corticoid-to-creatinine-ratio-in-cats-with-diabetes-mellitus-in-switzerland-and-the-netherlands
#14
Sandra Schaefer, Hans S Kooistra, Barbara Riond, Jan S Suchodolski, Jörg M Steiner, Marrit Prins, Eric Zini, Claudia E Reusch
OBJECTIVES: The aim of the study was to evaluate circulating insulin-like growth factor-1 (IGF-1), feline pancreas-specific lipase (fPLI) and total thyroxine (TT4) concentrations and urinary corticoid-to-creatinine ratio (UCCR) as indicators for the prevalence of acromegaly, pancreatitis, hyperthyroidism and hypercortisolism in cats with diabetes mellitus. METHODS: Blood and urine samples were collected from diabetic cats treated in primary care clinics in Switzerland and the Netherlands...
August 30, 2016: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/27571867/-not-available
#15
María Josefa Martínez Gómez, Cristóbal Melián Fernández, María Romeo Donlo
La enfermedad inflamatoria intestinal (EII) es una patología crónica que cursa en brotes. En los últimos años se ha visto un aumento de la incidencia, sobre todo en edades más tempranas. La malnutrición se encuentra frecuentemente asociada a esta patología, por tanto, es de vital importancia una intervención nutricional adecuada, especialmente en pacientes pediátricos, que intente asegurar no solo un óptimo crecimiento, sino también una mejoría de la clínica. Nuestro objetivo será actualizar, según la evidencia publicada, el conocimiento del papel de la nutrición en la enfermedad y en el tratamiento de la misma...
July 12, 2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/27541060/successful-treatment-of-a-chronic-abdominal-wall-seroma-with-the-polysaccharide-4dryfield-%C3%A2-ph-a-case-report
#16
Andreas Kuthe
INTRODUCTION: Seroma formation is one of the most prevalent complications after liposuction, abdominoplasty, mastectomy or hernia repair. They can disappear without treatment, but also may persist and require complex therapy. This report describes how 4DryField(®) PH polysaccharide powder successfully was applied for chronic seroma therapy. PRESENTATION OF THE CASE: An 80year old male patient presented with a persistent seroma (1000cm(3) volume) resulting from liposuction about 15 years ago...
2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27538838/variability-in-the-frequency-of-rheumatology-consultations-in-patients-with-rheumatoid-arthritis-in-spain
#17
R Lopez-Gonzalez, D Seoane-Mato, S Perez-Vicente, M A Martin-Martinez, F Sanchez-Alonso, L Silva-Fernandez
The aim of this work was to assess the variability in the use of health-care resources, based on the number of visits to rheumatology departments by rheumatoid arthritis patients, in Spain, and its association with patient, physician and center characteristics. The sample consisted of patient records of men and women (aged 16 or older), with a clinical diagnosis of RA, who met the American Rheumatism Association 1987 revised criteria and who had been treated in a rheumatology department at a Spanish hospital with at least one visit to a rheumatologist during the two years preceding the date of the study...
November 2016: Rheumatology International
https://www.readbyqxmd.com/read/27514140/-antenatal-application-of-corticosteroids-in-late-preterm-births
#18
REVIEW
M Mladenova, E Uchikova, E Dimitrakova, G Amaliev, N Parahuleva
The aim of the following study is to present the current evidence of antenatal use of corticoids in premature birth. The benefits of antenatal use of corticosteroids after 34 week of gestation is still a process of discussion.
2016: Akusherstvo i Ginekologii︠a︡
https://www.readbyqxmd.com/read/27509264/glucocorticoid-receptor-gene-variants-and-neonatal-outcome-in-very-low-birth-weight-preterm-infants
#19
Christine Schreiner, Felix Schreiner, Christoph Härtel, Matthias Heckmann, Axel Heep, Peter Bartmann, Joachim Woelfle, Andreas Müller, Egbert Herting, Wolfgang Göpel
BACKGROUND: Induction of lung maturation by prenatal steroid treatment has become the standard of care for pregnant women at risk for preterm birth. In addition to the beneficial effects on lung maturation, prenatal steroids have been shown to reduce the incidence of neonatal death, necrotizing enterocolitis, sepsis, and intraventricular hemorrhage. However, little is known about the role of interindividual differences in corticoid sensitivity arising from polymorphisms in the glucocorticoid receptor (GR) gene...
August 11, 2016: Neonatology
https://www.readbyqxmd.com/read/27449641/evaluating-the-efficacy-of-dexamethasone-in-the-treatment-of-patients-with-persistent-acute-respiratory-distress-syndrome-study-protocol-for-a-randomized-controlled-trial
#20
Jesús Villar, Javier Belda, José Manuel Añón, Jesús Blanco, Lina Pérez-Méndez, Carlos Ferrando, Domingo Martínez, Juan Alfonso Soler, Alfonso Ambrós, Tomás Muñoz, Rosana Rivas, Ruth Corpas, Francisco J Díaz-Dominguez, Marina Soro, Miguel Angel García-Bello, Rosa Lidia Fernández, Robert M Kacmarek
BACKGROUND: Although much has evolved in our understanding of the pathogenesis and factors affecting outcome of patients with acute respiratory distress syndrome (ARDS), still there is no specific pharmacologic treatment for ARDS. Several clinical trials have evaluated the utility of corticoids but none of them has demonstrated a definitive benefit due to small sample sizes, selection bias, patient heterogeneity, and time of initiation of treatment or duration of therapy. We postulated that adjunctive treatment of persistent ARDS with intravenous dexamethasone might change the pulmonary and systemic inflammatory response and thereby reduce morbidity, leading to a decrease in duration of mechanical ventilation and a decrease in mortality...
2016: Trials
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