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https://www.readbyqxmd.com/read/29217977/combined-treatment-of-vigabatrin-and-corticoids-for-infantile-spasms-a-superiority-complex-or-truly-superior-to-corticoids-monotherapy
#1
COMMENT
Ajay Gupta
No abstract text is available yet for this article.
November 2017: Epilepsy Currents
https://www.readbyqxmd.com/read/29204074/academic-stress-induced-changes-in-th1-and-th2-cytokine-response
#2
Areej M Assaf, Reem Al-Abbassi, Maysaa Al-Binni
Psychological stress stimulates physiological responses releasing catecholamines and corticoids, which act via corresponding receptors on immune cells, producing a shift in the cytokine balance. These responses are variable depending on the nature of stressors. The effect of the academic stress on the production of the Th1-cytokines (TNF-α, IFN-γ, IL-1β, IL-2, IL-6 and IL-8) and Th2-cytokines (IL-1ra, IL-4, IL-5 and IL-10) on 35 medical/health sciences students after completing their questionnaires was investigated...
December 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/29171446/do-infections-with-disseminated-mycobacterium-avium-complex-precede-sweet-s-syndrome-a-case-report-and-literature-review
#3
REVIEW
Kenji Hibiya, Kazuya Miyagi, Maki Tamayose, Daijiro Nabeya, Takeshi Kinjo, Syo Takeshima, Nanae Ikemiyagi, Keisuke Yamada, Akane Fujita, Hiroe Hashioka, Wakaki Kami, Morifumi Inamine, Daisuke Shibahara, Hideta Nakamura, Makoto Furugen, Shusaku Haranaga, Futoshi Higa, Masao Tateyama, Jiro Fujita
Sweet's syndrome is reportedly associated with preceding nontuberculous mycobacterial infections (NTMIs). Here, we report on a systemic Mycobacterium intracellulare infection in a patient on corticoid therapy for Sweet's syndrome. Literature searches show that 69.1% of patients with Sweet's syndrome and NTMIs developed this syndrome later than NTMIs and 89.3% of them developed during the clinical course of a rapidly growing mycobacterial infection. The residual cases were associated with slow-growing mycobacteria (14...
October 2017: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/29169713/-detection-and-codification-of-adverse-drug-reactions-in-a-mother-child-university-hospital
#4
M Harry, D Lebel, A Comtois, J-F Bussières
INTRODUCTION: In view of the underdeclaration of adverse drug reactions (ADRs), there is a need for optimizing their reporting. To improve our declaration, a pharmacovigilance program was started in 2006 at our center and measures were progressively started (weekly patient rounds, monthly report, etc.). The objectives of the study were to describe and compare the annual average incidence of the ADRs coded by the medical archivists from 1 April 1989 to 31 March 2010 (period 1) and from 1 April 2010 to 31 March 2015 (period 2), to determine the therapeutic classes of drugs associated with ADRs according to age and determine the percentage of ADRs that are declared to Health Canada...
November 20, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/29132968/canaliculitis-due-to-gemella-haemolysans-in-a-single-isolate
#5
J L Romero-Trevejo, J Somavilla-Lupiáñez
CASE REPORT: An 84 year-old woman was referred for evaluation of a painless swelling with small purulent discharge in her left upper canaliculus, and an associated epiphora of one-month duration. The patient was diagnosed with acute primary canaliculitis. She was treated with topical and oral antibiotics, as well as topical corticoids for three months, with little response. Surgical treatment with left upper canaliculotomy and curettage was then performed, and Gemella haemolysans was identified from the curetted material...
November 10, 2017: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/29033123/diagnosis-and-treatment-of-otitis-media-with-effusion-codepeh-recommendations
#6
Faustino Núñez-Batalla, Carmen Jáudenes-Casaubón, Jose Miguel Sequí-Canet, Ana Vivanco-Allende, Jose Zubicaray-Ugarteche
The incidence and the prevalence rates of otitis media with effusion (OME) are high. However, there is evidence that only a minority of professionals follow the recommendations provided in clinical practice guidelines. For the purpose of improving diagnosis and treatment of OME in children to prevent and/or reduce its impact on children's development, the Commission for the Early Detection of Deafness (CODEPEH) has deeply reviewed the scientific literature on this field and has drafted a document of recommendations for a correct clinical reaction to of OME, including diagnosis and medical and surgical treatment methodology...
October 13, 2017: Acta Otorrinolaringológica Española
https://www.readbyqxmd.com/read/29019594/allogeneic-mesenchymal-stem-cells-and-xenogenic-platelet-rich-plasma-associated-or-not-in-the-repair-of-bone-failures-in-rabbits-with-secondary-osteoporosis
#7
Mariá Andrade de Carvalho Rocha, Laís Meireles Costa Silva, Wellson Andrade de Oliveira, Dayseanny de Oliveira Bezerra, Gustavo Cardoso da Silva, Lucilene Dos Santos Silva, Brenda Lurian do Nascimento Medeiros, Sílvia de Araújo França Baêta, Maria Acelina Martins de Carvalho, Napoleão Martins Argôlo
PURPOSE: To assess the efficacy of allogeneic mesenchymal stem cells and xenogenic platelet rich plasma in the treatment of bone failure of osteoporotic rabbits secondary to estrogenic deprivation and iatrogenic hypercortisolism. METHODS: Eight female rabbits underwent ovarian resection and corticoid therapy to induce clinical status of osteoporosis. Four failures were produced in the tibiae, with each failure being treated with hemostatic sponge, allogenic mesenchymal stem cells, xenogenic platelet-rich plasma and the association between both...
September 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/28992897/inflammatory-bowel-disease-and-eating-disorders-a-systematized-review-of-comorbidity
#8
REVIEW
L Ilzarbe, M Fàbrega, R Quintero, A Bastidas, L Pintor, J García-Campayo, F Gomollón, D Ilzarbe
OBJECTIVE: Research has shown that there is an association between Inflammatory Bowel Disease, anxiety and mood disorders, however little is known about their association with Eating Disorders. In this paper we will present a case of a young female with a comorbid diagnosis of Inflammatory Bowel Disease and Eating Disorder, and then discuss the results from a systematic review of the literature, describing published cases of patients with the same condition. METHODS: A systematized review of the literature was conducted according to MOOSE guidelines...
November 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28977167/11%C3%AE-hydroxysteroid-dehydrogenase-type-ii-activity-is-affected-by-grapefruit-juice-and-intense-muscular-work
#9
Christopher Kargl, Mohammad Arshad, Fahad Salman, Regina C Schurman, Pedro Del Corral
OBJECTIVE: The enzymatic activity of 11β-hydroxysteroid dehydrogenase-2 (11β-HSD2) is key to protecting mineral corticoid receptors from cortisol and has been implicated in blood pressure regulation. Grapefruit juice (GFJ) and acidity are thought to inhibit this enzyme in vitro. This study examines the effect of GFJ and intense exercise on 11β-HSD2 enzyme activity in vivo. SUBJECTS AND METHODS: Eighteen subjects ingested GFJ or apple juice (CON) on separate days prior to reporting to the laboratory in a randomized order...
September 18, 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28963086/developing-an-exogenous-pulmonary-surfactant-glucocorticoids-association-effect-of-corticoid-concentration-on-the-biophysical-properties-of-the-surfactant
#10
Alejandra Cimato, Graciela Facorro, Margarita Martínez Sarrasague
Glucocorticoids (GCs) are used to treat lung disease. GCs incorporated in an exogenous pulmonary surfactant (EPS) could be an alternative management to improve drug delivery avoiding side effects. In the development of these pharmaceutical products, it is important to know the maximum amount of GC that can be incorporated and if increasing quantities of GCs alter EPS biophysical properties. Formulations containing EPS and beclomethasone, budesonide or fluticasone were analyzed (PL 10mg/ml; GC 1-2mg/ml). The microstructure was evaluated by electron paramagnetic resonance spectroscopy, GCs incorporated were determined by UV absorption and polarized light microscopy and surfactant activity with pulsating bubble surfactometer...
September 27, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28947388/the-brain-gut-axis-of-fish-rainbow-trout-with-low-and-high-cortisol-response-show-innate-differences-in-intestinal-integrity-and-brain-gene-expression
#11
Malin Rosengren, Per-Ove Thörnqvist, Svante Winberg, Kristina Sundell
In fish, the stress hormone cortisol is released through the hypothalamic pituitary interrenal axis (HPI-axis).The reactivity of this axis differs between individuals and previous studies have linked this to different behavioural characteristics and stress coping styles. The current study examines the expression of stress related genes in the brain and investigates the stress sensitive barrier function of the intestine of low and high responding rainbow trout (LR and HR) in terms of cortisol release. LR and HR rainbow trout were identified using repeated confinement stress tests...
September 22, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28927806/-aging-prevention-new-surgical-techniques-and-future-options-for-facial-rejuvenation
#12
C Le Louarn
Prevention of aging is mainly obtained through appropriate health practices, modulated by the genetic causes of aging. Causes of facial structural aging include gravity, volume loss, contraction of the mimic muscles and obviously biological aging of tissues. Among the very numerous new surgical technique of facial rejuvenation, we could point out: for the frontal region, obviously we are focus on the endoscopic and non-endoscopic frontal lifts. But also, we should note the transcutaneous Brow Shaping which with a well defined, step by step technique is indeed a simple way to improve a possible difficult situation; concerning the mid-face lift, as the main risk is the secondary eyelid malposition, a high Smas or a temporo-malar lift can be performed...
October 2017: Annales de Chirurgie Plastique et Esthétique
https://www.readbyqxmd.com/read/28921035/-midportion-achilles-tendinopathy
#13
REVIEW
J Weber, T Buchhorn
Although the incidence of midportion Achilles tendinopathy is under 1% in the general population, it is quite a common disease in runners that is characterized by the symptom triad of pain, swelling and impaired physical performance. Pain and swelling are located in the area 2 to 7 cm proximal the tendon insertion onto the calcaneus.Diagnosis is made by adequate clinical symptoms and corresponding findings in sonography and/or magnetic resonance imaging scans. Histopathologically, mostly degenerative changes in the tendon structure are found, sometimes accompanied by intra- and paratendinous inflammation...
September 18, 2017: Der Unfallchirurg
https://www.readbyqxmd.com/read/28900820/outcome-of-childhood-leukaemia-survivors-and-necrosis-of-the-femoral-head-treated-with-autologous-mesenchymal-stem-cells
#14
T de Rojas, S Martínez-Álvarez, S Lerma-Lara, M Á Díaz, L Madero, M Ramírez
PURPOSE: Corticoid-induced osteonecrosis (ON) of femoral head can lead to severe hip joint impairment and hip replacement, with negative impact in young survivors of acute lymphoblastic leukaemia (ALL) with long life expectancy. We aim to improve quality of life in these patients with a novel approach. METHODS/PATIENTS: Based on the regenerative capacities of mesenchymal stem cells (MSCs), we performed locally implanted autologous cell therapy in two adolescents suffering of bilateral femoral ON...
September 12, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28879650/vascular-and-cardiac-function-in-young-adults-with-classical-congenital-adrenal-hyperplasia
#15
Joanna Wierzbicka-Chmiel, Artur Chmiel, Sławomir Rychlik, Monika Ogrodowczyk-Bobik, Bogdan Marek, Dariusz Kajdaniuk
INTRODUCTION: Patients with classical congenital adrenal hyperplasia (CAH) have increased cardiovascular risk, but the vascular and cardiac function during longitudinal corticoids replacement therapy is not known thoroughly. MATERIAL AND METHODS: Cross-sectional study of 19 Caucasian adults with CAH (age 23.7 ± 3.8 years; twelve males) compared to 20 healthy volunteers matched for origin, sex, age, and body mass index (BMI). All of the participants were assessed for flow mediated dilatation of the brachial artery (FMD), intima-media thickness of the common carotid artery (cIMT) and common femoral artery (fIMT), standard echocardiography, and global longitudinal left ventricular function using two-dimensional speckle-tracking echocardiography (LSTE)...
September 7, 2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/28866684/functional-connectivity-pattern-of-the-internal-hippocampal-network-in-awake-pigeons-a-resting-state-fmri-study
#16
Mehdi Behroozi, Felix Ströckens, Xavier Helluy, Martin Stacho, Onur Güntürkün
In the last two decades, the avian hippocampus has been repeatedly studied with respect to its architecture, neurochemistry, and connectivity pattern. We review these insights and conclude that we unfortunately still lack proper knowledge on the interaction between the different hippocampal subregions. To fill this gap, we need information on the functional connectivity pattern of the hippocampal network. These data could complement our structural connectivity knowledge. To this end, we conducted a resting-state fMRI experiment in awake pigeons in a 7-T MR scanner...
2017: Brain, Behavior and Evolution
https://www.readbyqxmd.com/read/28856015/antenatal-corticosteroid-treatment-for-the-prevention-of-peri-intraventricular-haemorrhage-in-preterm-newborns-a-retrospective-cohort-study-using-transfontanelle-ultrasonography
#17
Bianca A Almeida, Livia T Rios, Edward Araujo Júnior, Luciano M Nardozza, Antonio F Moron, Marília G Martins
OBJECTIVE: The objective of this study was to assess the correlation between antenatal corticosteroids and peri-intraventricular haemorrhage (PIVH) using transfontanelle ultrasonography, as well as to evaluate the risk factors for its incidence. METHODS: We performed a retrospective cohort study using medical records of preterm newborns. The protocol for maternal corticoid administration for foetal lung maturation included dexamethasone 4 mg (intramuscular) 8/8 hours per 48 hours, with one cycle per week...
June 2017: Journal of Ultrasonography
https://www.readbyqxmd.com/read/28833282/palatal-perforation-and-chemical-ulcers-of-the-tongue-in-a-blind-patient
#18
Tiago Novaes Pinheiro, Flavio Fayad, Luiz Roberto Magalhães Júnior, Brigitte Nichthauser, Francisco Braga, Shirley Maria Passos
We report a unique case of a potassium aluminum sulfate oral dissolution leading to palatal chemical necrosis and extensive chemical ulcers on the tongue. The patient, a 47-year-old white, blind male, denied using cocaine or other illegal drugs that could cause such lesions. His self-medication started as a treatment for a traumatic ulcerative lesion on the hard palate. After palatal perforation, he started another self-medication routine, mixing corticoid cream and tandrilax tablets with a gauze obturator...
August 22, 2017: Special Care in Dentistry
https://www.readbyqxmd.com/read/28821968/near-adult-height-in-male-kidney-transplant-recipients-started-on-growth-hormone-treatment-in-late-puberty
#19
Silvia Gil, Mariana Aziz, Marta Adragna, Marta Monteverde, Alicia Belgorosky
BACKGROUND: Growth retardation and its impact on adult height is considered to be one of the most common complications in patients with chronic kidney disease (CKD). Treatment with recombinant human growth hormone (rhGH) has been effective in improving growth in kidney transplantation (KTx) patients, but little data are available on adult height in patients who began rhGh treatment in late puberty. METHODS: Near-adult height was evaluated in 13 KTx patients treated with rhGH [growth hormone group (GHGr); dose 9...
January 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28810615/detecting-serum-and-urine-metabolic-profile-changes-of-ccl4-liver-fibrosis-in-rats-at-12-weeks-based-on-gas-chromatography-mass-spectrometry
#20
Jiarong Gao, Xiu-Juan Qin, Hui Jiang, Jin-Feng Chen, Ting Wang, Ting Zhang, Shuang-Zhi Xu, Jun-Mei Song
Liver fibrosis is caused by liver injury induced by a number of chronic liver diseases, including schistosome infection, hepatitis infection, metabolic disease, alcoholism and cholestasis. The tissue damage occurring after injury or inflammation of the liver is a reversible lesion; however, liver fibrosis has become a worldwide problem and poses a threat to human health. The development of an effective drug for the prevention and treatment of liver fibrosis is ongoing and uses information from different occurrences of liver fibrosis...
August 2017: Experimental and Therapeutic Medicine
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