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https://www.readbyqxmd.com/read/29656363/2-pentadecyl-2-oxazoline-reduces-neuroinflammatory-environment-in-the-mptp-model-of-parkinson-disease
#1
Marika Cordaro, Rosalba Siracusa, Rosalia Crupi, Daniela Impellizzeri, Alessio Filippo Peritore, Ramona D'Amico, Enrico Gugliandolo, Rosanna Di Paola, Salvatore Cuzzocrea
Current pharmacological management of Parkinson disease (PD) does not provide for disease modification, but addresses only symptomatic features. Here, we explore a new approach to neuroprotection based on the use of 2-pentadecyl-2-oxazoline (PEA-OXA), the oxazoline derivative of the fatty acid amide signaling molecule palmitoylethanolamide (PEA), in an experimental model of PD. Daily oral treatment with PEA-OXA (10 mg/kg) significantly reduced behavioral impairments and neuronal cell degeneration of the dopaminergic tract induced by four intraperitoneal injections of the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on 8-week-old male C57 mice...
April 14, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29651747/tauroursodeoxycholic-acid-improves-motor-symptoms-in-a-mouse-model-of-parkinson-s-disease
#2
Alexandra Isabel Rosa, Sara Duarte-Silva, Anabela Silva-Fernandes, Maria João Nunes, Andreia Neves Carvalho, Elsa Rodrigues, Maria João Gama, Cecília Maria Pereira Rodrigues, Patrícia Maciel, Margarida Castro-Caldas
Parkinson's disease (PD) is characterized by severe motor symptoms, and currently there is no treatment that retards disease progression or reverses damage prior to the time of clinical diagnosis. Tauroursodeoxycholic acid (TUDCA) is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of PD; however, its effect in PD motor symptoms has never been addressed. In the present work, an extensive behavior analysis was performed to better characterize the MPTP model of PD and to evaluate the effects of TUDCA in the prevention/improvement of mice phenotype...
April 12, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29649746/degradation-of-alpha-synuclein-by-dendritic-cell-factor-1-delays-neurodegeneration-and-extends-lifespan-in-drosophila
#3
Shiqing Zhang, Ruili Feng, Yanhui Li, Linhua Gan, Fangfang Zhou, Shiquan Meng, Qian Li, Tieqiao Wen
Parkinson's disease (PD) is a common neurodegenerative disease associated with the progressive loss of dopaminergic neurons in the substantia nigra. Proteinaceous depositions of alpha-synuclein (α-syn) and its mutations, A30P and A53T, are one important characteristic of PD. However, little is known about their aggregation and degradation mechanisms. Dendritic cell factor 1 (DCF1) is a membrane protein that plays important roles in nerve development in mouse. In this study, we aimed to show that DCF1 overexpression in a PD Drosophila model significantly ameliorates impaired locomotor behavior in third instar larvae and normalizes neuromuscular junction growth...
March 13, 2018: Neurobiology of Aging
https://www.readbyqxmd.com/read/29649621/astrocyte-specific-dj-1-overexpression-protects-against-rotenone-induced-neurotoxicity-in-a-rat-model-of-parkinson-s-disease
#4
Briana R De Miranda, Emily M Rocha, Qing Bai, Amina El Ayadi, David Hinkle, Edward A Burton, J Timothy Greenamyre
DJ-1 is a redox-sensitive protein with several putative functions important in mitochondrial physiology, protein transcription, proteasome regulation, and chaperone activity. High levels of DJ-1 immunoreactivity are reported in astrocytes surrounding pathology associated with idiopathic Parkinson's disease, possibly reflecting the glial response to oxidative damage. Previous studies showed that astrocytic over-expression of DJ-1 in vitro prevented oxidative stress and mitochondrial dysfunction in primary neurons...
April 9, 2018: Neurobiology of Disease
https://www.readbyqxmd.com/read/29649511/interference-of-carbidopa-and-other-catechols-with-reactions-catalyzed-by-peroxidases
#5
Beata Gąsowska-Bajger, Yuki Nishigaya, Krystyna Hirsz-Wiktorzak, Anna Rybczyńska, Toshimasa Yamazaki, Hubert Wojtasek
BACKGROUND: A number of compounds, including ascorbic acid, catecholamines, flavonoids, p-diphenols and hydrazine derivatives have been reported to interfere with peroxidase-based medical diagnostic tests (Trinder reaction) but the mechanisms of these effects have not been fully elucidated. METHODS: Reactions of bovine myeloperoxidase with o-dianisidine, bovine lactoperoxidase with ABTS and horseradish peroxidase with 4-aminoantipyrine/phenol in the presence of carbidopa, an anti-Parkinsonian drug, and other catechols, including l-dopa, were monitored spectrophotometrically and by measuring hydrogen peroxide consumption...
April 9, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29644334/objective-measurement-in-routine-care-of-people-with-parkinson-s-disease-improves-outcomes
#6
Parisa Farzanehfar, Holly Woodrow, Michelle Braybrook, Sarah McGregor, Andrew Evans, Frank Nicklason, Malcolm Horne
It is common in medicine to titrate therapy according to target ranges of objectively measured parameters. Objective measurement of motor function is available for Parkinson's Disease (PD), making it possible to optimise therapy and clinical outcomes. In this study, an accelerometry based measurement and predefined target ranges were used to assess motor function in a Northern Tasmania PD cohort managed by a Movement Disorder clinic. Approximately 40% ( n  = 103) of the total PD population participated in this study and motor scores were within target in 22%...
2018: NPJ Parkinson's Disease
https://www.readbyqxmd.com/read/29628812/exercise-therapy-for-a-patient-with-parkinson-disease-and-back-pain-a-case-report
#7
Christina L Rosarion
Objective: The purpose of this report is to describe an exercise intervention for an elderly patient with Parkinson disease with a chief complaint of lower back pain. Clinical Features: The patient was an 85-year-old man who had been diagnosed with Parkinson disease and kyphosis. Back pain was preventing him from carrying out activities of daily living. He was referred for physical therapy for treatment to reduce lower back pain and increase function. An initial examination consisted of testing flexibility and range of motion and administering a pain severity scale and a Lower Extremity Functional Index (LEFI); the patient's initial LEFI score was 14/80...
March 2018: Journal of Chiropractic Medicine
https://www.readbyqxmd.com/read/29628303/overexpression-of-tfeb-drives-a-pleiotropic-neurotrophic-effect-and-prevents-parkinson-s-disease-related-neurodegeneration
#8
Albert Torra, Annabelle Parent, Thais Cuadros, Beatriz Rodríguez-Galván, Esther Ruiz-Bronchal, Andrea Ballabio, Analía Bortolozzi, Miquel Vila, Jordi Bové
The possible implication of transcription factor EB (TFEB) as a therapeutic target in Parkinson's disease has gained momentum since it was discovered that TFEB controls lysosomal biogenesis and autophagy and that its activation might counteract lysosomal impairment and protein aggregation. However, the majority of putative direct targets of TFEB described to date is linked to a range of biological processes that are not related to the lysosomal-autophagic system. Here, we assessed the effect of overexpressing TFEB with an adeno-associated viral vector in mouse substantia nigra dopaminergic neurons...
February 27, 2018: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/29621183/tau-induced-pathology-in-epilepsy-and-dementia-notions-from-patients-and-animal-models
#9
REVIEW
Marina P Sánchez, Ana M García-Cabrero, Gentzane Sánchez-Elexpuru, Daniel F Burgos, José M Serratosa
Patients with dementia present epilepsy more frequently than the general population. Seizures are more common in patients with Alzheimer's disease (AD), dementia with Lewy bodies (LBD), frontotemporal dementia (FTD) and progressive supranuclear palsy (PSP) than in other dementias. Missense mutations in the microtubule associated protein tau (MAPT) gene have been found to cause familial FTD and PSP, while the P301S mutation in MAPT has been associated with early-onset fast progressive dementia and the presence of seizures...
April 5, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29617109/targeted-brain-delivery-of-rabies-virus-glycoprotein-29-modified-deferoxamine-loaded-nanoparticles-reverses-functional-deficits-in-parkinsonian-mice
#10
Linhao You, Jing Wang, Tianqing Liu, Yinlong Zhang, Xuexiang Han, Ting Wang, Shanshan Guo, Tianyu Dong, Junchao Xu, Gregory J Anderson, Qiang Liu, Yan-Zhong Chang, Xin Lou, Guangjun Nie
Excess iron deposition in the brain often causes oxidative stress-related damage and necrosis of dopaminergic neurons in the substantia nigra and has been reported to be one of the major vulnerability factors in Parkinson's disease (PD). Iron chelation therapy using deferoxamine (DFO) may inhibit this nigrostriatal degeneration and prevent the progress of PD. However, DFO shows very short half-life in vivo and hardly penetrates the blood brain barrier (BBB). Hence, it is of great interest to develop DFO formulations for safe and efficient intracerebral drug delivery...
April 4, 2018: ACS Nano
https://www.readbyqxmd.com/read/29615705/gdnf-expressing-macrophages-mitigate-loss-of-dopamine-neurons-and-improve-parkinsonian-symptoms-in-mitopark-mice
#11
Cang Chen, Xiuhua Li, Guo Ge, Jingwei Liu, K C Biju, Suzette D Laing, Yusheng Qian, Cori Ballard, Zhixu He, Eliezer Masliah, Robert A Clark, Jason C O'Connor, Senlin Li
Glial cell line-derived neurotrophic factor (GDNF) is the most potent neuroprotective agent tested in cellular and animal models of Parkinson's disease (PD). However, CNS delivery of GDNF is restricted by the blood-brain barrier (BBB). Using total body irradiation as transplant preconditioning, we previously reported that hematopoietic stem cell (HSC) transplantation (HSCT)-based macrophage-mediated gene therapy could deliver GDNF to the brain to prevent degeneration of nigrostriatal dopamine (DA) neurons in an acute murine neurotoxicity model...
April 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29614698/cognitive-rehabilitation-in-parkinson-s-disease-a-systematic-review
#12
Hamad Alzahrani, Annalena Venneri
BACKGROUND: Cognitive impairments are the most common non-motor symptoms in Parkinson's disease (PD). These symptoms have a negative impact on patients' quality of life and daily living activities. This review will focus on published articles that investigated the efficacy of cognitive rehabilitation in PD. OBJECTIVES: To review the existing literature on the efficacy of cognitive rehabilitation in PD and highlight the most effective form of intervention to prevent cognitive decline...
March 26, 2018: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/29606187/the-serum-exosome-derived-microrna-135a-193b-and-384-were-potential-alzheimer-s-disease-biomarkers
#13
Ting Ting Yang, Chen Geng Liu, Shi Chao Gao, Yi Zhang, Pei Chang Wang
OBJECTIVE: MicroRNAs (miRs) are attractive molecules to be considered as one of the blood-based biomarkers for neurodegenerative disorders such as Alzheimer's disease (AD). The goal of this study was to explore their potential value as biomarkers for the diagnosis of AD. METHODS: The expression levels of exosomal miR-135a, -193b, and -384 in the serum from mild cognitive impairment (MCI), dementia of Alzheimer-type (DAT), Parkinson's disease with dementia (PDD), and vascular dementia (VaD) patients were measured with a real-time quantitative reverse transcriptase PCR (qRT-PCR) method...
February 2018: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/29604316/effect-of-phytate-and-zinc-ions-on-fluoride-toothpaste-efficacy-using-an-in-situ-caries-model
#14
Charles Parkinson, Gary R Burnett, Jon Creeth, Richard Lynch, Chandrashekhar Budhawant, Frank Lippert, Anderson T Hara, Domenick T Zero
OBJECTIVES: To compare and explore the dose-response of phytate-containing 1150 ppm fluoride toothpastes on model caries lesions and to determine the impact of zinc ions. METHODS: This was a single-centre, randomised, blinded (examiner/laboratory analyst), six-treatment, four-period crossover, in situ study in adults with a removable bilateral maxillary partial denture. Study treatments were toothpastes containing: 0.425% phytate/F; 0.85% phytate/F; 0.85% phytate/Zn/F; F-only; Zn/F and a 0% F placebo...
March 28, 2018: Journal of Dentistry
https://www.readbyqxmd.com/read/29601727/paradoxical-effect-of-trehalose-on-the-aggregation-of-%C3%AE-synuclein-expedites-onset-of-aggregation-yet-reduces-fibril-load
#15
Nidhi Katyal, Manish Agarwal, Raktim Sen, Vinay Kumar, Shashank Deep
Aggregation of α-synuclein is closely connected to the pathology of Parkinson's disease. The phenomenon involves multiple steps, commenced by partial misfolding and eventually leading to mature amyloid fibril formation. Trehalose, a widely accepted osmolyte, has been shown previously to inhibit aggregation of various globular proteins owing to its ability to prevent the initial unfolding of protein. In this study, we have examined if it behaves in a similar fashion with intrinsically disordered protein α-synuclein and possesses the potential to act as therapeutic agent against Parkinson's disease...
March 30, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29588573/vitexin-protects-dopaminergic-neurons-in-mptp-induced-parkinson-s-disease-through-pi3k-akt-signaling-pathway
#16
Ming Hu, Fangming Li, Weidong Wang
Parkinson's disease (PD) is a progressive neurodegenerative disease which is characterized by the degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc). Methods: In this study, the neuroprotective effect of vitexin (Vit), a flavonoid compound isolated from Crataegus pinnatifida Bunge was examined in PD models both in vitro and in vivo. Results: On SH-SY5Y cells, methyl-4-phenylpyridine (MPP+ ) treatment suppressed cell viability, induced apoptosis, and increased Bax/Bcl-2 ratio and caspase-3 activity...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29582396/the-effects-of-non-selective-dopamine-receptor-activation-by-apomorphine-in-the-mouse-hippocampus
#17
Luis Enrique Arroyo-García, Rubén Antonio Vázquez-Roque, Alfonso Díaz, Samuel Treviño, Fidel De La Cruz, Gonzalo Flores, Antonio Rodríguez-Moreno
Apomorphine is a dopamine receptor agonist that activates D1 -D5 dopamine receptors and that is used to treat Parkinson's disease (PD). However, the effect of apomorphine on non-motor activity has been poorly studied, and likewise, the effects of dopaminergic activation in brain areas that do not fulfill motor functions are unclear. The aim of this study was to determine how dopamine receptor activation affects behavior, as well as plasticity, morphology, and oxidative stress in the hippocampus. Adult mice were chronically administered apomorphine (1 mg/kg for 15 days), and the effects on memory and learning, synaptic plasticity, dendritic length, inflammatory responses, and oxidative stress were evaluated...
March 26, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29581333/reader-response-expression-of-concern-does-compensatory-hyperparathyroidism-predispose-to-ischemic-stroke-decreased-bone-mass-and-increased-bone-turnover-with-valproate-therapy-in-adults-with-epilepsy-an-alternative-to-vitamin-d-supplementation-to-prevent-fractures
#18
COMMENT
https://www.readbyqxmd.com/read/29581332/editors-note-expression-of-concern-does-compensatory-hyperparathyroidism-predispose-to-ischemic-stroke-decreased-bone-mass-and-increased-bone-turnover-with-valproate-therapy-in-adults-with-epilepsy-an-alternative-to-vitamin-d-supplementation-to-prevent-fractures
#19
COMMENT
https://www.readbyqxmd.com/read/29572571/exploring-the-relationship-between-motor-impairment-vascular-burden-and-cognition-in-parkinson-s-disease
#20
Tanja Stojkovic, Elka Stefanova, Ivan Soldatovic, Vladana Markovic, Iva Stankovic, Igor Petrovic, Federica Agosta, Sebastiano Galantucci, Massimo Filippi, Vladimir Kostic
OBJECTIVE: To determine frequency and type of cognitive disorders in cross-sectional analysis of a Parkinson's disease (PD) cohort, and explore its relations to motor symptoms, modifiable vascular risk factors and white matter lesions (WML) volume. METHODS: In a group of 133 PD patients, mild cognitive impairment (PD-MCI) and dementia (PDD) were diagnosed according to Movement Disorders Society Task Force criteria (level 2 for PD-MCI). Detailed motor measurements were applied, including rigidity, axial, bradykinesia, tremor and postural instability gait disorders (PIGD) scores...
March 23, 2018: Journal of Neurology
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