Sudhasini Panda, Jeffrey Morgan, Catherine Cheng, Mayuko Saito, Robert H Gilman, Nelly Ciobanu, Valeriu Crudu, Donald G Catanzaro, Antonino Catanzaro, Timothy Rodwell, Judy S B Perera, Teshan Chathuranga, Bandu Gunasena, Aruna D DeSilva, Bjoern Peters, Alessandro Sette, Cecilia S Lindestam Arlehamn
There is still incomplete knowledge of which Mycobacterium tuberculosis (Mtb) antigens can trigger distinct T cell responses at different stages of infection. Here, a proteome-wide screen of 20,610 Mtb-derived peptides in 21 patients mid-treatment for active tuberculosis (ATB) reveals IFNγ-specific T cell responses against 137 unique epitopes. Of these, 16% are recognized by two or more participants and predominantly derived from cell wall and cell processes antigens. There is differential recognition of antigens, including TB vaccine candidate antigens, between ATB participants and interferon-gamma release assay (IGRA + /-) individuals...
January 26, 2024: Nature Communications