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https://www.readbyqxmd.com/read/29457998/home-based-neuromuscular-electrical-stimulation-as-an-add-on-to-pulmonary-rehabilitation-does-not-provide-further-benefits-in-patients-with-chronic-obstructive-pulmonary-disease-a-multicenter-randomized-trial
#1
Tristan Bonnevie, Francis-Edouard Gravier, David Debeaumont, Catherine Viacroze, Jean-François Muir, Antoine Cuvelier, Marie Netchitaïlo, Anne Laure Roy, Jean Quieffin, Marie-Hélène Marques, Clément Médrinal, Johan Dupuis, Catherine Tardif
OBJECTIVE: To assess the additional effect of a home-based neuro muscular electrical stimulation (NMES) program as an add-on to pulmonary rehabilitation (PR), on functional capacity in subjects with chronic obstructive pulmonary disease (COPD). DESIGN: Single-blind, multicenter randomized trial. SETTING: Three PR centers. PARTICIPANTS: Subjects with severe to very severe COPD referred for PR (n=73; median FEV1, 1 (0...
February 16, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29456174/bilateral-maculopathy-after-exposure-to-a-laser-pointer-optical-coherence-tomography-angiography-findings
#2
R Clemente-Tomás, P Bayo-Calduch, P Neira-Ibáñez, A Gargallo-Benedicto, A M Duch-Samper
CASE REPORT: A 36-year-old man went to the emergency department the day after exposure to a laser pointer. Funduscopy revealed dispersed macular pigment alterations, and optical coherence tomography showed a disruption of the retinal layers. The visual acuity was counting fingers in both eyes. Nine months later, optical coherence tomography angiography showed a rarefaction in the choriocapillaris vascular flow in the area of the laser injuries. DISCUSSION: The retinal layer mainly damaged by the laser injury was the retinal pigment epithelium...
February 15, 2018: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/29450750/survival-impact-of-stations-of-pathological-lymph-nodes-in-n2-non-small-cell-lung-cancer-in-a-french-hospital
#3
Christelle Clément-Duchêne, Amandine Luc, Jean-Matthieu Casse, Jean-Michel Vignaud, Stéphanie Lacomme, Valentine Anne, Joëlle Siat, Olivier Ménard, Yves Martinet
BACKGROUND: The prognosis of lung cancer remains poor; only 20% of patients can undergo surgery. N2 non-small cell lung cancer (NSCLC) is a heterogeneous disease. We conducted a retrospective study to analyze the impact of N2 location on survival. METHODS: This study included 342 NSCLC with N2 involvement between 1988 and 2014. Patient-related data were collected through the CRB biobank and included demographic, therapeutic, and survival data. Survival was analyzed according to Kaplan-Maier method...
February 14, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29450028/implementation-of-a-novel-synchronous-multi-site-all-day-high-fidelity-simulation
#4
Paul Abraham, Franck Verdonk, Clement Buleon, Antoine Tesniere, Marc Lilot
Integration of simulation in educational curricula for anesthesia and intensive care residents is a hot topic. There is a great interest for simulation centers to share their experiences through multi-site synchronous simulation sessions. The present study results from an experience conducted at three sites in France (Paris, Lyon, and Caen), which involved 16 instructors and 25 residents facing the same scenario across 1 day. Synchronous simulations were performed at each site with local and shared debriefing via teleconference...
2018: Advances in Simulation
https://www.readbyqxmd.com/read/29449637/facile-emulsion-mediated-synthesis-of-phase-pure-diopside-nanoparticles
#5
Elena Tajuelo Rodriguez, Lawrence M Anovitz, Caleb D Clement, Adam J Rondinone, Michael C Cheshire
Diopside is a common natural pyroxene that is rarely found in a pure state, since magnesium is often partially substituted by iron, and other elements (sodium and aluminum) are often present. This pyroxene, along with feldspars and olivines, is common in concrete. As the prospective license renewal of light water reactors to 80 years of operation has raised concerns on the effects of radiation in the concrete biological shield surrounding the reactors, mineral nanoparticles can be valuable to perform amorphization studies to inform predictive models of mechanical properties of irradiated concrete...
February 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29449420/childhood-stature-and-growth-in-relation-to-first-ischemic-stroke-or-intracerebral-hemorrhage
#6
Line Klingen Gjærde, Thomas Clement Truelsen, Jennifer Lyn Baker
BACKGROUND AND PURPOSE: Attained height, an indicator of genetic potential and childhood growth environment, is inversely associated with stroke, but the mechanisms are poorly understood. We investigated whether childhood height and growth are associated with ischemic stroke (IS) and intracerebral hemorrhage (ICH). METHODS: In a cohort of Danish schoolchildren born 1930 to 1989, with measured height from 7 to 13 years, we investigated associations of childhood stature and growth with risks of adult IS and ICH...
February 15, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29449344/defeating-major-contaminants-in-fe-3-imac-phosphopeptide-enrichment
#7
Clement M Potel, Miao-Hsia Lin, Albert J R Heck, Simone Lemeer
Here we demonstrate that biomolecular contaminants, such as nucleic acid molecules, can seriously interfere with IMAC based phosphopeptide enrichments. We address and largely solve this issue, developing a robust protocol implementing methanol/chloroform protein precipitation and enzymatic digestion using benzonase, which degrades all forms of DNA and RNA, prior to IMAC-column loading. This simple procedure resulted in a drastic increase of enrichment sensitivity, enabling the identification of around 17,000 unique phosphopeptides and 12,500 unambiguously localized phosphosites in human cell-lines from a single LC-MS/MS run, constituting a 50% increase when compared to the standard protocol...
February 15, 2018: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/29447157/an-inconclusive-study-comparing-the-effect-of-concrete-and-abstract-descriptions-of-belief-inconsistent-information
#8
Katherine A Collins, Richard Clément
Linguistic bias is the differential use of linguistic abstraction (as defined by the Linguistic Category Model) to describe the same behaviour for members of different groups. Essentially, it is the tendency to use concrete language for belief-inconsistent behaviours and abstract language for belief-consistent behaviours. Having found that linguistic bias is produced without intention or awareness in many contexts, researchers argue that linguistic bias reflects, reinforces, and transmits pre-existing beliefs, thus playing a role in belief maintenance...
2018: PloS One
https://www.readbyqxmd.com/read/29447131/dna-repair-deficiency-sensitizes-lung-cancer-cells-to-nad-biosynthesis-blockade
#9
Mehdi Touat, Tony Sourisseau, Nicolas Dorvault, Roman M Chabanon, Marlène Garrido, Daphné Morel, Dragomir B Krastev, Ludovic Bigot, Julien Adam, Jessica Frankum, Sylvère Durand, Clement Pontoizeau, Sylvie Souquère, Mei-Shiue Kuo, Sylvie Sauvaigo, Faraz Mardakheh, Alain Sarasin, Ken A Olaussen, Luc Friboulet, Frédéric Bouillaud, Gérard Pierron, Alan Ashworth, Anne Lombès, Christopher J Lord, Jean-Charles Soria, Sophie Postel-Vinay
Synthetic lethality is an efficient mechanism-based approach to selectively target DNA repair defects. ERCC1 deficiency is frequently found in non-small cell lung cancers, making this DNA repair protein an attractive target for exploiting synthetic lethal approaches in this disease. Using unbiased proteomic and metabolic high-throughput profiling on a unique in-house generated isogenic model of ERCC1 deficiency, we found marked metabolic rewiring of ERCC1-deficient populations, including decreased levels of the metabolite NAD+ and reduced expression of the rate-limiting NAD+ biosynthetic enzyme nicotinamide phosphoribosyltransferase (NAMPT)...
February 15, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29446317/credentialing-of-radiotherapy-centres-in-australasia-for-trog-09-02-chisel-a-phase-iii-clinical-trial-on-stereotactic-ablative-body-radiotherapy-of-early-stage-lung-cancer
#10
Tomas Kron, Brent Chesson, Nicholas Hardcastle, Melissa Crain, Natalie Clements, Mark Burns, David Ball
OBJECTIVE: A randomised clinical trial comparing Stereotactic Ablative Body Radiotherapy (SABR) with conventional radiotherapy for early stage lung cancer has been conducted in Australia and New Zealand under the auspices of the TransTasman Radiation Oncology Group (NCT01014130). We report on the technical credentialing program as prerequisite for centres joining the trial. METHODS: Participating centres were asked to develop treatment plans for two test cases to assess their ability to create plans according to protocol...
February 15, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29445385/-fagopyrum-esculentum-alters-its-root-exudation-after-amaranthus-retroflexus-recognition-and-suppresses-weed-growth
#11
Aurélie Gfeller, Gaétan Glauser, Clément Etter, Constant Signarbieux, Judith Wirth
Weed control by crops through growth suppressive root exudates is a promising alternative to herbicides. Buckwheat ( Fagopyrum esculentum ) is known for its weed suppression and redroot pigweed ( Amaranthus retroflexus ) control is probably partly due to allelopathic root exudates. This work studies whether other weeds are also suppressed by buckwheat and if the presence of weeds is necessary to induce growth repression. Buckwheat and different weeds were co-cultivated in soil, separating roots by a mesh allowing to study effects due to diffusion...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29444437/mutations-in-cytosine-5-trna-methyltransferases-impact-mobile-element-expression-and-genome-stability-at-specific-dna-repeats
#12
Bianca Genenncher, Zeljko Durdevic, Katharina Hanna, Daniela Zinkl, Mehrpouya Balaghy Mobin, Nevcin Senturk, Bruno Da Silva, Carine Legrand, Clément Carré, Frank Lyko, Matthias Schaefer
The maintenance of eukaryotic genome stability is ensured by the interplay of transcriptional as well as post-transcriptional mechanisms that control recombination of repeat regions and the expression and mobility of transposable elements. We report here that mutations in two (cytosine-5) RNA methyltransferases, Dnmt2 and NSun2, impact the accumulation of mobile element-derived sequences and DNA repeat integrity in Drosophila. Loss of Dnmt2 function caused moderate effects under standard conditions, while heat shock exacerbated these effects...
February 13, 2018: Cell Reports
https://www.readbyqxmd.com/read/29444017/kerr-lens-mode-locked-yb-calgo-thin-disk-laser
#13
Norbert Modsching, Clément Paradis, François Labaye, Maxim Gaponenko, Ivan J Graumann, Andreas Diebold, Florian Emaury, Valentin J Wittwer, Thomas Südmeyer
We demonstrate the first Kerr lens mode-locked Yb:CaGdAlO4(Yb:CALGO) thin-disk laser oscillator. It generates pulses with a duration of 30 fs at a central wavelength of 1048 nm and a repetition rate of 124 MHz. The laser emits the shortest pulses generated by a thin-disk laser oscillator, equal to the shortest pulse duration obtained by Yb-doped bulk oscillators. The average output power is currently limited to 150 mW by the low gain and limited disk quality. We expect that more suitable Yb:CALGO disks will enable substantially higher power levels with similar pulse durations...
February 15, 2018: Optics Letters
https://www.readbyqxmd.com/read/29443880/magnetic-nanoparticles-interact-and-pass-an-in-vitro-co-culture-blood-placenta-barrier-model
#14
Elena K Müller, Christine Gräfe, Frank Wiekhorst, Christian Bergemann, Andreas Weidner, Silvio Dutz, Joachim H Clement
Magnetic nanoparticles are interesting tools for biomedicine. Before application, critical prerequisites have to be fulfilled. An important issue is the contact and interaction with biological barriers such as the blood-placenta barrier. In order to study these processes in detail, suitable in vitro models are needed. For that purpose a blood-placenta barrier model based on the trophoblast-like cell line BeWo and primary placenta-derived pericytes was established. This model was characterized by molecular permeability, transepithelial electrical resistance and cell-cell-contact markers...
February 14, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29443560/adolescent-pregnancy-prevention-in-group-homes-recruiting-and-retention-considerations
#15
Roy F Oman, Sara K Vesely, Kristen Clements-Nolle, Janene Fluhr
No abstract text is available yet for this article.
February 2018: American Journal of Public Health
https://www.readbyqxmd.com/read/29443557/adolescent-pregnancy-prevention-among-youths-living-in-group-care-homes-a-cluster-randomized-controlled-trial
#16
Roy F Oman, Sara K Vesely, Jennifer Green, Kristen Clements-Nolle, Minggen Lu
OBJECTIVES: To determine if the Power Through Choices (PTC) intervention can increase the use of birth control and reduce pregnancy among system-involved youths living in group care homes. METHODS: We performed a 2-arm cluster randomized controlled trial involving group care homes operated by child welfare or juvenile justice systems in California, Maryland, and Oklahoma with assessments immediately before and after the intervention, and at 6- and 12-month follow-up...
February 2018: American Journal of Public Health
https://www.readbyqxmd.com/read/29442611/relative-toxicity-of-benzodiazepines-and-hypnotics-commonly-used-for-self-poisoning-an-epidemiological-study-of-fatal-toxicity-and-case-fatality
#17
Galit Geulayov, Anne Ferrey, Deborah Casey, Claudia Wells, Alice Fuller, Clare Bankhead, David Gunnell, Caroline Clements, Navneet Kapur, Jennifer Ness, Keith Waters, Keith Hawton
The relative toxicity of anxiolytic and hypnotic drugs commonly used for self-poisoning was assessed using data on suicides, prescriptions and non-fatal self-poisonings in England, 2005-2012. Data on suicide by self-poisoning were obtained from the Office for National Statistics, information on intentional non-fatal self-poisoning was derived from the Multicentre Study of Self-harm in England and data on prescriptions in general practice from the Clinical Practice Research Datalink. We used two indices of relative toxicity: fatal toxicity (the number of fatal self-poisonings relative to the number of individuals prescribed each drug) and case fatality (the number of fatal relative to non-fatal self-poisonings)...
February 1, 2018: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/29442408/the-long-history-of-health-inequality-in-new-zealand-occupational-class-and-lifespan-in-the-late-1800s-and-early-1900s
#18
Nick Wilson, Christine Clement, Matt Boyd, Andrea Teng, Alistair Woodward, Tony Blakely
OBJECTIVE: As relatively little is known about how socioeconomic position might have affected health prior to the Second World War, we aimed to study lifespan by occupational class in two cohorts in New Zealand. METHODS: The first study included men on the electoral rolls in Dunedin in the period 1893 to 1902. The second study used an established cohort of male military personnel who were recruited for the First World War. Linear regression was used to estimate lifespan by occupational class...
February 14, 2018: Australian and New Zealand Journal of Public Health
https://www.readbyqxmd.com/read/29440653/genetic-and-morphological-support-for-possible-sympatric-origin-of-fish-from-subterranean-habitats
#19
Iraj Hashemzadeh Segherloo, Eric Normandeau, Laura Benestan, Clément Rougeux, Guillaume Coté, Jean-Sébastien Moore, NabiAllah Ghaedrahmati, Asghar Abdoli, Louis Bernatchez
Two blind Iran cave barbs, Garra typhlops and Garra lorestanensis, exist in sympatry in a single subterranean habitat, raising the hypothesis that they may represent a case of sympatric speciation following a colonization event. Their different mental disc forms have prompted some authors to propose the alternative hypothesis of two separate colonization events. In this study, we analysed a genome-wide panel of 11,257 SNPs genotyped by means of genotyping-by-sequencing combined with mitochondrial cytochrome c oxidase sub-unit I sequence data, field observations and morphological traits to test these two hypotheses...
February 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29440162/sequelae-of-multidrug-resistant-tuberculosis-protocol-for-a-systematic-review-and-meta-analysis
#20
Kefyalew Addis Alene, Archie C A Clements, Emma S McBryde, Ernesto Jaramillo, Knut Lonnroth, Debebe Shaweno, Kerri Viney
INTRODUCTION: The sequelae of multidrug-resistant tuberculosis (MDR-TB) are poorly understood and inconsistently reported. We will aim to assess the existing evidence for the clinical, psychological, social and economic sequelae of MDR-TB and to assess the health-related quality of life in patients with MDR-TB. METHODS AND ANALYSIS: We will perform a systematic review and meta-analysis of published studies reporting sequelae of MDR-TB. We will search PubMed, SCOPUS, ProQuest, Web of Science and PsychINFO databases up to 5 September 2017...
February 10, 2018: BMJ Open
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