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https://www.readbyqxmd.com/read/28818985/somatostatin-antagonists-for-radioligand-therapy-of-non-endocrine-tumors
#1
Elif Hindie, Paolo Zanotti-Fregonara, Clément Morgat
No abstract text is available yet for this article.
August 17, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28818374/cell-wall-modifications-of-two-arabidopsis-thaliana-ecotypes-col-and-sha-in-response-to-sub-optimal-growth-conditions-an-integrative-study
#2
Harold Duruflé, Vincent Hervé, Philippe Ranocha, Thierry Balliau, Michel Zivy, Josiane Chourré, Hélène San Clemente, Vincent Burlat, Cécile Albenne, Sébastien Déjean, Elisabeth Jamet, Christophe Dunand
With the global temperature change, plant adaptations are predicted, but little is known about the molecular mechanisms underlying them. Arabidopsis thaliana is a model plant adapted to various environmental conditions, in particular able to develop along an altitudinal gradient. Two ecotypes, Columbia (Col) growing at low altitude, and Shahdara (Sha) growing at 3400m, have been studied at optimal and sub-optimal growth temperature (22°C vs 15°C). Macro- and micro-phenotyping, cell wall monosaccharides analyses, cell wall proteomics, and transcriptomics have been performed in order to accomplish an integrative analysis...
October 2017: Plant Science: An International Journal of Experimental Plant Biology
https://www.readbyqxmd.com/read/28817597/a-unified-censored-normal-regression-model-for-qpcr-differential-gene-expression-analysis
#3
Peter Pipelers, Lieven Clement, Matthijs Vynck, Jan Hellemans, Jo Vandesompele, Olivier Thas
Reverse transcription quantitative polymerase chain reaction (RT-qPCR) is considered as the gold standard for accurate, sensitive, and fast measurement of gene expression. Prior to downstream statistical analysis, RT-qPCR fluorescence amplification curves are summarized into one single value, the quantification cycle (Cq). When RT-qPCR does not reach the limit of detection, the Cq is labeled as "undetermined". Current state of the art qPCR data analysis pipelines acknowledge the importance of normalization for removing non-biological sample to sample variation in the Cq values...
2017: PloS One
https://www.readbyqxmd.com/read/28816051/lipid-stabilized-water-oil-interfaces-studied-by-micro-focusing-small-angle-x-ray-scattering
#4
Emanuela Di Cola, Kristian Torbensen, Ilaria Clemente, Federico Rossi, Sandra Ristori, Ali Abou-Hassan
Water in oil (w/o) simple emulsions are dispersed micro-confined systems which find applications in many areas of advanced materials and biotechnology, such as food industry, drug delivery and cosmetics, to name but a few. In these systems, the structural and chemical properties of the boundary layer at the w/o interface are of paramount importance to determine functionality and stability. Recently, microfluidic methods have emerged as a valuable tool to fabricate monodisperse emulsion droplets. Due to the intrinsic flexibility of microfluidics, different interfaces can be obtained, and general principles governing the interfacial stability are needed to guide the experimental approach...
August 17, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28815735/traps-and-transformations-influencing-the-financial-viability-of-tourism-on-private-land-conservation-areas
#5
Hayley S Clements, Graeme S Cumming
The ability of private conservation organizations to remain financially viable is a key factor influencing their effectiveness. A third of financially-motivated private land conservation areas (PLCAs) surveyed previously in South Africa were found to be unprofitable, raising questions about their ability to effectively adapt their business models to their socioeconomic environment. In any complex system, options for later adaptation can be constrained by starting conditions ('path dependence'). We tested three hypothesized drivers that might create path dependence in PLCA business models: (H1) land asset size (large mammalian game abundance is constrained by available land area); (H2) infrastructural asset extent (the introduction of charismatic predators, such as lion, requires substantial infrastructural investment); and (H3) productivity (rainfall limits vegetation and thereby game abundance)...
August 17, 2017: Conservation Biology: the Journal of the Society for Conservation Biology
https://www.readbyqxmd.com/read/28815178/stem-cell-manipulation-gene-therapy-and-the-risk-of-cancer-stem-cell-emergence
#6
REVIEW
Flora Clément, Elodie Grockowiak, Florence Zylbersztejn, Gaëlle Fossard, Stéphanie Gobert, Véronique Maguer-Satta
Stem cells (SCs) have been extensively studied in the context of regenerative medicine. Human hematopoietic stem cell (HSC)-based therapies have been applied to treat leukemic patients for decades. Handling of mesenchymal stem cells (MSCs) has also raised hopes and concerns in the field of tissue engineering. Lately, discovery of cell reprogramming by Yamanaka's team has profoundly modified research strategies and approaches in this domain. As we gain further insight into cell fate mechanisms and identification of key actors and parameters, this also raises issues as to the manipulation of SCs...
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/28814729/thermally-induced-crystallization-hole-transport-nlo-and-photovoltaic-activity-of-a-bis-diarylamine-based-push-pull-molecule
#7
Yue Jiang, Magali Allain, Denis Gindre, Sylvie Dabos-Seignon, Philippe Blanchard, Clément Cabanetos, Jean Roncali
The synthesis of a molecule constituted of two diarylamine-based push-pull chromophores covalently linked via their nitrogen atom is described. Comparison of the electronic properties with the parent monomer shows that dimerization has negligible influence on the electronic properties of the molecule but exerts a dramatic impact on the capacity of the material to self-reorganize. Application of thermal annealing to thin films induces the crystallization under original morphologies, a process accompanied by a partial bleaching of the absorption in the visible range and by a huge increase of hole-mobility...
August 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28814400/mediation-and-modification-of-genetic-susceptibility-to-obesity-by-eating-behaviors
#8
Blandine de Lauzon-Guillain, Emma Ad Clifton, Felix R Day, Karine Clément, Soren Brage, Nita G Forouhi, Simon J Griffin, Yves Akoli Koudou, Véronique Pelloux, Nicholas J Wareham, Marie-Aline Charles, Barbara Heude, Ken K Ong
Background: Many genetic variants show highly robust associations with body mass index (BMI). However, the mechanisms through which genetic susceptibility to obesity operates are not well understood. Potentially modifiable mechanisms, including eating behaviors, are of particular interest to public health.Objective: Here we explore whether eating behaviors mediate or modify genetic susceptibility to obesity.Design: Genetic risk scores for BMI (BMI-GRSs) were calculated for 3515 and 2154 adults in the Fenland and EDEN (Etude des déterminants pré et postnatals de la santé et du développement de l'enfant) population-based cohort studies, respectively...
August 16, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28814276/treatment-outcomes-of-patients-with-multidrug-resistant-and-extensively-drug-resistant-tuberculosis-in-hunan-province-china
#9
Kefyalew Addis Alene, Hengzhong Yi, Kerri Viney, Emma S McBryde, Kunyun Yang, Liqiong Bai, Darren J Gray, Archie C A Clements, Zuhui Xu
BACKGROUND: The worldwide emergence of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) has posed additional challenges for global tuberculosis (TB) control efforts, as limited treatment options are available and treatment outcomes are often sub-optimal. This study determined treatment outcomes among a cohort of MDR-TB and XDR-TB patients in Hunan Province, China, and identified factors associated with poor treatment outcomes. METHODS: We conducted a retrospective study using data obtained from medical records of TB patients in Hunan Chest Hospital, and from the internet-based TB management information system managed by the Tuberculosis Control Institute of Hunan Province, for the period 2011 to 2014...
August 16, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28813974/a-cosmetic-prosthetic-digit-with-bioinspired-embedded-touch-feedback
#10
Diego Barone, Marco D'Alonzo, Marco Controzzi, Francesco Clemente, Christian Cipriani
Partial hand amputation is the most frequent amputation level worldwide, accounting for approximately 90% of all upper limb amputations. Passive cosmetic prostheses represent one of the possible choices for its treatment, probably the most affordable one. However, these devices restore very limited motor function and subtle sensory feedback. The latter is an important component for restoring the body schema. In this work we present a simple yet potentially effective and low cost cosmetic digital prosthesis that embeds touch feedback; we dubbed this DESC-finger...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28813952/comparative-performance-analysis-of-m-imu-emg-and-voice-user-interfaces-for-assistive-robots
#11
Clemente Laureiti, Francesca Cordella, Francesco Scotto di Luzio, Stefano Saccucci, Angelo Davalli, Rinaldo Sacchetti, Loredana Zollo
People with a high level of disability experience great difficulties to perform activities of daily living and resort to their residual motor functions in order to operate assistive devices. The commercially available interfaces used to control assistive manipulators are typically based on joysticks and can be used only by subjects with upper-limb residual mobilities. Many other solutions can be found in the literature, based on the use of multiple sensory systems for detecting the human motion intention and state...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28813917/intuitive-adaptive-orientation-control-of-assistive-robots-for-people-living-with-upper-limb-disabilities
#12
Dinh-Son Vu, Ulysse Cote Allard, Clement Gosselin, Francois Routhier, Benoit Gosselin, Alexandre Campeau-Lecours
Robotic assistive devices enhance the autonomy of individuals living with physical disabilities in their day-to-day life. Although the first priority for such devices is safety, they must also be intuitive and efficient from an engineering point of view in order to be adopted by a broad range of users. This is especially true for assistive robotic arms, as they are used for the complex control tasks of daily living. One challenge in the control of such assistive robots is the management of the end-effector orientation which is not always intuitive for the human operator, especially for neophytes...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28813580/genetic-association-of-the-parl-abcc5-htr3d-htr3c-locus-with-primary-angle-closure-glaucoma-in-chinese
#13
Fang Yao Tang, Li Ma, Pancy O S Tam, Chi Pui Pang, Clement C Y Tham, Li Jia Chen
Purpose: This study evaluates the associations of haplotype-tagging single nucleotide polymorphisms (SNPs) in the PARL-ABCC5-HTR3D-HTR3C region with primary angle closure glaucoma (PACG), with a view to identify the responsible SNP in this region. Methods: Thirty SNPs from the PARL-ABCC5-HTR3D-HTR3C region were genotyped in a Hong Kong Chinese cohort of 422 PACG patients and 400 control subjects, using TaqMan SNP genotyping assays. Single marker and haplotype-based association analyses were performed...
August 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28813234/cardiac-mr-strain-a-noninvasive-biomarker-of-fibrofatty-remodeling-of-the-left-atrial-myocardium
#14
Adrian T Huber, Jérôme Lamy, Amer Rahhal, Morgane Evin, Fabrice Atassi, Carine Defrance, Guillaume Lebreton, Karine Clément, Myriam Berthet, Richard Isnard, Pascal Leprince, Philippe Cluzel, Stéphane N Hatem, Nadjia Kachenoura, Alban Redheuil
Purpose To determine whether left atrial (LA) strain quantification with cardiac magnetic resonance (MR) imaging feature tracking is associated with the severity of LA fibrofatty myocardial remodeling at histologic analysis. Materials and Methods This prospective case-control study was approved by the institutional review board. LA strain was evaluated with cardiac MR feature tracking between January 2014 and March 2015 in 13 consecutive patients (mean age, 61 years ± 19; nine male) with mitral regurgitation in the 24 hours before mitral valve surgery and 13 age- and sex-matched healthy control subjects...
August 16, 2017: Radiology
https://www.readbyqxmd.com/read/28812591/body-size-shifts-and-early-warning-signals-precede-the-historic-collapse-of-whale-stocks
#15
Christopher F Clements, Julia L Blanchard, Kirsty L Nash, Mark A Hindell, Arpat Ozgul
Predicting population declines is a key challenge in the face of global environmental change. Abundance-based early warning signals have been shown to precede population collapses; however, such signals are sensitive to the low reliability of abundance estimates. Here, using historical data on whales harvested during the 20th century, we demonstrate that early warning signals can be present not only in the abundance data, but also in the more reliable body size data of wild populations. We show that during the period of commercial whaling, the mean body size of caught whales declined dramatically (by up to 4 m over a 70-year period), leading to early warning signals being detectable up to 40 years before the global collapse of whale stocks...
June 22, 2017: Nature ecology & evolution
https://www.readbyqxmd.com/read/28812157/augmented-reality-in-a-tumor-resection-model
#16
Pauline Chauvet, Toby Collins, Clement Debize, Lorraine Novais-Gameiro, Bruno Pereira, Adrien Bartoli, Michel Canis, Nicolas Bourdel
BACKGROUND: Augmented Reality (AR) guidance is a technology that allows a surgeon to see sub-surface structures, by overlaying pre-operative imaging data on a live laparoscopic video. Our objectives were to evaluate a state-of-the-art AR guidance system in a tumor surgical resection model, comparing the accuracy of the resection with and without the system. Our system has three phases. Phase 1: using the MRI images, the kidney's and pseudotumor's surfaces are segmented to construct a 3D model...
August 15, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28811478/reduced-and-unstratified-crust-in-cv-chondrite-parent-body
#17
Clément Ganino, Guy Libourel
Early Solar System planetesimal thermal models predict the heating of the chondritic protolith and the preservation of a chondritic crust on differentiated parent bodies. Petrological and geochemical analyses of chondrites have suggested that secondary alteration phases formed at low temperatures (<300 °C) by fluid-rock interaction where reduced and oxidized Vigarano type Carbonaceous (CV) chondrites witness different physicochemical conditions. From a thermodynamical survey of Ca-Fe-rich secondary phases in CV3 chondrites including silica activity (aSiO2), here we show that the classical distinction between reduced and oxidized chondrites is no longer valid and that their Ca-Fe-rich secondary phases formed in similar reduced conditions near the iron-magnetite redox buffer at low aSiO2 (log(aSiO2) <-1) and moderate temperature (210-610 °C)...
August 15, 2017: Nature Communications
https://www.readbyqxmd.com/read/28811349/brain-macrophages-in-simian-immunodeficiency-virus-infected-antiretroviral-suppressed-macaques-a-functional-latent-reservoir
#18
Claudia R Avalos, Celina M Abreu, Suzanne E Queen, Ming Li, Sarah Price, Erin N Shirk, Elizabeth L Engle, Ellen Forsyth, Brandon T Bullock, Feilim Mac Gabhann, Stephen W Wietgrefe, Ashley T Haase, M Christine Zink, Joseph L Mankowski, Janice E Clements, Lucio Gama
A human immunodeficiency virus (HIV) infection cure requires an understanding of the cellular and anatomical sites harboring virus that contribute to viral rebound upon treatment interruption. Despite antiretroviral therapy (ART), HIV-associated neurocognitive disorders (HAND) are reported in HIV-infected individuals on ART. Biomarkers for macrophage activation and neuronal damage in cerebrospinal fluid (CSF) of HIV-infected individuals demonstrate continued effects of HIV in brain and suggest that the central nervous system (CNS) may serve as a viral reservoir...
August 15, 2017: MBio
https://www.readbyqxmd.com/read/28811191/can-psychological-well-being-scales-and-hormone-levels-be-used-to-predict-acute-performance-of-anaerobic-training-tasks-in-elite-female-volleyball-players
#19
Juan Mielgo-Ayuso, Michael C Zourdos, Vicente J Clemente-Suárez, Julio Calleja-González, Amber M Shipherd
The purpose of this study was to examine relationships between pre-training psychological well-being assessment scales (General Health Questionnaire-28-GHQ-28, Competitive State Anxiety Inventory-2-CSAI-2, Sport Competition Anxiety Test-SCAT, State-Trait Anxiety Inventory-S-STAI-S, Oviedo Sleep Questionnaire-OSQ and Psychological Characteristics Related to Sport Performance-PCSP), and pre-training stress hormone concentrations (cortisol-C, total testosterone-TT, free testosterone-FT, adrenocorticotropic hormone-ACTH and testosterone/cortisol-T/C ratios), on acute neuromuscular performance (ANP) in female volleyballers...
August 12, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28808712/from-aqueous-speciation-to-supramolecular-assembly-in-alkaline-earth-uranyl-polyoxometalates
#20
Clément Falaise, Sarah M Hickam, Peter C Burns, May Nyman
The interplay between aqueous alkaline earth (Ca, Sr, Ba) polycationic speciation and uranyl-peroxide polyoxometalate self-assembly and evolution is described here using solution (Raman and X-ray scattering) and solid-state (microscopy, X-ray diffraction) characterization. Supramolecular assembly of Sr-encapsulated and decorated polyanions and polycations yields the fourth largest inorganic unit cell reported from single-crystal X-ray diffraction.
August 15, 2017: Chemical Communications: Chem Comm
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