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https://www.readbyqxmd.com/read/29684916/predictors-of-rapid-cognitive-decline-in-patients-with-mild-to-moderate-alzheimer-disease-a-prospective-cohort-study-with-12-month-follow-up-performed-in-memory-clinics
#1
Achille E Tchalla, Jean-Pierre Clément, Isabelle Saulnier, Betty Beaumatin, Florent Lachal, Caroline Gayot, Anaïs Bosetti, Iléana Desormais, Anaïck Perrochon, Pierre-Marie Preux, Philippe Couratier, Thierry Dantoine
BACKGROUND/AIMS: Alzheimer disease (AD) is particularly devastating, with no cure, no means of prevention, and no proven way to slow progression. AD is associated with the worsening of cognitive function attributable to a variety of factors of which little is known. Our main objective was to determine factors associated with rapid cognitive decline (RCD) in older AD patients. METHODS: We conducted a 12-month, prospective, multi-centre cohort study. Community-living individuals aged ≥65 years with mild-to-moderate AD were included...
April 23, 2018: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/29684766/characterization-and-competitive-ability-of-non-aflatoxigenic-aspergillus-flavus-isolated-from-the-maize-agro-ecosystem-in-argentina-as-potential-aflatoxin-biocontrol-agents
#2
María Silvina Alaniz Zanon, María Paz Clemente, Sofía Noemí Chulze
Aspergillus flavus is an opportunistic pathogen and may produce aflatoxins in maize, one of the most important crops in Argentina. A promising strategy to reduce aflatoxin accumulation is the biological control based on competitive exclusion. In order to select potential biocontrol agents among isolates from the maize growing region in Argentina, a total of 512 A. flavus strains were isolated from maize kernels and soil samples. Thirty-six per cent of the isolates from maize kernels did not produce detectable levels of aflatoxins, while 73% of the isolates from soil were characterized as non-aflatoxin producers...
April 13, 2018: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29684672/epigenetic-modulation-by-small-molecule-compounds-for-neurodegenerative-disorders
#3
REVIEW
Akash Kumar Singh, Sarmistha Halder Sinha, James P Clement, Tapas K Kundu
The accumulation of somatic and genetic mutations which altered the structure and coding information of the DNA are the major cause of neurological disorders. However, our recent understanding of molecular mechanisms of 'epigenetic' phenomenon reveals that the modifications of chromatin play a significant role in the development and severity of neurological disorders. These epigenetic processes are dynamic and reversible as compared to genetic ablations which are stable and irreversible. Therefore, targeting these epigenetic processes through small molecule modulators are of great therapeutic potential...
April 20, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29683845/adverse-fetal-and-infant-outcomes-among-hiv-infected-women-who-received-either-nnrti-or-pi-based-art-for-pmtct
#4
Rose Masaba, Craig B Borkowf, Sonali Girde, Clement Zeh, Richard Ndivo, Isabella Nyang'au, Kevin Achola, Timothy K Thomas, Shirley Lee Lecher
BACKGROUND: For HIV-infected pregnant and breastfeeding women, antiretroviral therapy (ART) is known to reduce the mother's risk of passing the infection to her child. However, concerns remain about possible associations between various components of different ART regimens and adverse fetal and infant outcomes. As part of a clinical trial in western Kenya for the prevention of mother-to-child transmission (PMTCT) of HIV, pregnant women received one of two different ART regimens. METHODS: The original PMTCT study conducted in Kenya enrolled 522 HIV-infected, ART-naïve pregnant women...
April 19, 2018: AIDS
https://www.readbyqxmd.com/read/29683524/fetal-sex-determination-in-twin-pregnancies-using-cell-free-fetal-dna-analysis
#5
Miguel Milan, Emilia Mateu, David Blesa, Monica Clemente-Ciscar, Carlos Simon
OBJECTIVE(S): We sought to develop an accurate sex classification method in twin pregnancies using data obtained from a standard commercial non-invasive prenatal test. STUDY DESIGN: A total of 706 twin pregnancies were included in this retrospective analytical data study. Normalized chromosome values for chromosomes X and Y were used and adapted into a sex-score to predict fetal sex in each fetus and results were compared to the clinical outcome at birth. RESULTS: Outcome information at birth for sex chromosomes was available for 232 twin pregnancies...
April 23, 2018: Prenatal Diagnosis
https://www.readbyqxmd.com/read/29680774/targeting-hypothalamic-pituitary-adrenal-axis-hormones-and-sex-steroids-for-improving-cognition-in-major-mood-disorders-and-schizophrenia-a-systematic-review-and-narrative-synthesis
#6
REVIEW
Virginia Soria, Alexandre González-Rodríguez, Elena Huerta-Ramos, Judith Usall, Jesús Cobo, Miquel Bioque, Juan David Barbero, Clemente García-Rizo, Meritxell Tost, José Antonio Monreal, Javier Labad
Cognitive deficits are a core feature of serious mental illnesses such as schizophrenia, major depressive disorder (MDD) and bipolar disorder (BD) and are a common cause of functional disability. There is limited efficacy of pharmacological interventions for improving the cognitive deficits in these disorders. As pro-cognitive pharmacological treatments are lacking, hormones or drugs that target the endocrine system may become potential candidates for 'repurposing' trials aiming to improve cognition. We aimed to study whether treatment with drugs targeting the hypothalamic-pituitary-adrenal (HPA) axis and sex steroids can improve cognition in patients with schizophrenia, MDD or BD...
April 14, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29680528/benthic-foraminiferal-and-organic-matter-compounds-as-proxies-of-environmental-quality-in-a-tropical-coastal-lagoon-the-itaipu-lagoon-brazil
#7
Débora Raposo, Iara Clemente, Marcos Figueiredo, Amanda Vilar, Maria Lucia Lorini, Fabrizio Frontalini, Virgínia Martins, Pierre Belart, Luiz Fontana, Renan Habib, Lazaro Laut
Lagoons in the southeast coast of Brazil have experienced eutrophication due to the exponential increase of human population and sewage discharges. Living benthic foraminifera have demonstrated to be good bioindicators of such impacts. This study aims to evaluate the organic matter accumulation effects on the foraminiferal distribution in the Itaipu lagoon (Brazil). On the basis of the biotic and abiotic analyses, three sectors are identified. The Sector I, an inner area, is characterized by high dissolved oxygen values and foraminiferal species with preference for marine conditions, demonstrating the sea influence...
April 2018: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/29680457/recommendations-regarding-the-genetic-and-immunological-study-of-reproductive-dysfunction
#8
María Concepción Alonso-Cerezo, Mercedes Calero Ruiz, Venancio Chantada-Abal, Luis Alfonso de la Fuente-Hernández, Inmaculada García-Cobaleda, Carlos García-Ochoa, José Miguel García-Sagredo, Rocío Nuñez, Rafael Oliva, María Orera-Clemente, David Pintado-Vera, Silvia Sanchez-Ramon
In this article several members of diverse scientific associations and reproduction experts from Spain have updated different genetic and immunological procedure recommendations in couples affected by reproductive dysfunction with the goal of providing a set of useful guidelines for the clinic. The laboratory test has been considered as highly recommendable for making clinical decisions when the result of the diagnostic test is relevant, moderately recommendable when the results are of limited evidence because they are inconsistent, and low when the benefit of the test is uncertain...
April 19, 2018: Medicina Clínica
https://www.readbyqxmd.com/read/29680145/3-10-le-risque-chimique-intentionnel
#9
Isabelle Klein, Axelle Montels, Kilian Bertho, Clément Derkenne, Hugues Lefort
No abstract text is available yet for this article.
April 2018: Soins; la Revue de Référence Infirmière
https://www.readbyqxmd.com/read/29679747/age-hiv-status-and-research-context-determined-attrition-in-a-longitudinal-cohort-in-nigeria
#10
Eileen O Dareng, Yinka Olaniyan, Sally N Adebamowo, Olabimpe R Eseyin, Michael K Odutola, Elonna M Obiefuna, Richard A Offiong, Paul P Pharoah, Clement A Adebamowo
OBJECTIVE: We explored determinants of attrition a longitudinal cohort study in Nigeria. STUDY DESIGN AND SETTING: We enroled 1,020 women into a prospective study. Of these, 973 were eligible to return for follow-up. We investigated the determinants of attrition among eligible women using a sequential mixed methods design. We used logistic regression models to compare the baseline characteristics of responders and non-responders. At the end of the parent study, we conducted 4 focus group discussions and 8 key informant interviews with non-responders RESULTS: Of the 973 women included in the quantitative analysis, 26% were non-responders...
April 18, 2018: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/29679428/estimating-sensitivity-of-seabed-habitats-to-disturbance-by-bottom-trawling-based-on-the-longevity-of-benthic-fauna
#11
Adriaan D Rijnsdorp, Stefan G Bolam, Clement Garcia, Jan Geert Hiddink, Niels T Hintzen, P Daniel van Denderen, Tobias van Kooten
Bottom fishing such as trawling and dredging may pose serious risks to the seabed and benthic habitats, calling for a quantitative assessment method to evaluate the impact and guide management to develop mitigation measures. We provide a method to estimate the sensitivity of benthic habitats based on the longevity composition of the invertebrate community. We hypothesize that long-lived species are more sensitive to trawling mortality due to their lower pace of life (i.e. slower growth, late maturation). We analyse data from box-core and grab samples taken from 401 stations in the English Channel and southern North Sea to estimate the habitat-specific longevity composition of the benthic invertebrate community and of specific functional groups (i...
April 20, 2018: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/29678957/a-new-role-for-extracellular-vesicles-how-small-vesicles-can-feed-tumors-big-appetite
#12
Ikrame Lazar, Emily Clement, Camille Attane, Catherine Muller, Laurence Nieto
Cancer cells must adapt their metabolism in order to meet the energy requirements for cell proliferation, survival in nutrient-deprived environments and dissemination. In particular, fatty acid metabolism is emerging as a critical process for tumors. Fatty acid metabolism can be modulated through intrinsic changes in gene expression or signaling between tumor cells, but also in response to signals from the surrounding microenvironment. Among these signals, extracellular vesicles could play an important role in fatty acid metabolism remodeling...
April 20, 2018: Journal of Lipid Research
https://www.readbyqxmd.com/read/29678937/identification-of-a-specific-functional-network-altered-in-poststroke-cognitive-impairment
#13
Clément Bournonville, Hilde Hénon, Thibaut Dondaine, Christine Delmaire, Stephanie Bombois, Anne-Marie Mendyk, Charlotte Cordonnier, Solène Moulin, Xavier Leclerc, Régis Bordet, Renaud Lopes
OBJECTIVE: To study the association between poststroke cognitive impairment and defining a specific resting functional marker. METHODS: The resting-state functional connectivity 6 months after an ischemic stroke in 56 patients was investigated. Twenty-nine of the patients who had an impairment of one or several cognitive domains were compared to 27 without any cognitive deficit. We studied the whole-brain connectivity using 2 complementary approaches: graph theory to study the functional network organization and network-based statistics to explore connectivity between brain regions...
April 20, 2018: Neurology
https://www.readbyqxmd.com/read/29678902/development-of-a-breast-cancer-risk-prediction-model-for-women-in-nigeria
#14
Shengfeng Wang, Temidayo O Ogundiran, Adeyinka Ademola, Olayiwola A Oluwasola, Adewunmi O Adeoye, Adenike Sofoluwe, Imran Morhason-Bello, Stella O Odedina, Imaria Agwai, Clement Adebamowo, Millicent Obajimi, Oladosu Ojengbede, Olufunmilayo I Olopade, Dezheng Huo
BACKGROUND: Risk prediction models have been widely used to identify women at higher risk of breast cancer. We aim to develop a model for absolute breast cancer risk prediction for Nigerian women. METHODS: A total of 1,811 breast cancer cases and 2,225 controls from the Nigerian Breast Cancer Study (NBCS, 1998~2015) were included. Subjects were randomly divided into the training and validation sets. Incorporating local incidence rates, multivariable logistic regressions were used to develop the model...
April 20, 2018: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/29678363/congenital-lingual-artery-aneurysm-as-an-unusual-cause-of-upper-gastrointestinal-bleeding
#15
M M Ramírez-Ramírez, U E Clemente-Gutiérrez, M Silva-González, H M Zúñiga-Zamora, A R Sánchez-Conejo
No abstract text is available yet for this article.
April 17, 2018: Revista de Gastroenterología de México
https://www.readbyqxmd.com/read/29678139/pulmonary-hemosiderosis-in-children-with-down-syndrome-a-national-experience
#16
Aurelia Alimi, Jessica Taytard, Rola Abou Taam, Véronique Houdouin, Aude Forgeron, Marc Lubrano Lavadera, Pierrick Cros, Isabelle Gibertini, Jocelyne Derelle, Antoine Deschildre, Caroline Thumerelle, Ralph Epaud, Philippe Reix, Michael Fayon, Sylvie Roullaud, Françoise Troussier, Marie-Catherine Renoux, Jacques de Blic, Sophie Leyronnas, Guillaume Thouvenin, Caroline Perisson, Aimé Ravel, Annick Clement, Harriet Corvol, Nadia Nathan
BACKGROUND: Pulmonary hemosiderosis is a rare and complex disease in children. A previous study from the French RespiRare® network led to two important findings: 20% of the children presented with both pulmonary hemosiderosis and Down syndrome (DS), and at least one tested autoantibody was found positive in 50%. This study investigates the relationships between pulmonary hemosiderosis and DS. METHODS: Patients younger than 20 years old and followed for pulmonary hemosiderosis were retrieved from the RespiRare® database...
April 20, 2018: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/29677914/integrating-biobank-data-into-a-clinical-data-research-network-the-ibcb-project
#17
Guillaume Bouzille, Vianney Jouhet, Bruno Turlin, Bruno Clement, Mireille Desille, Christine Riou, Moufid Hajjar, Denis Delamarre, Danielle Le Quilleuc, Frantz Thiessard, Marc Cuggia
Development of biobanks is still hampered by difficulty to collect high quality sample annotations using patient clinical information. The IBCB project evaluated the feasibility of a nationwide clinical data research network for this purpose. METHOD: the infrastructure, based on eHOP and I2B2 technologies, was interfaced with the legacy IT components of 3 hospitals. The evaluation focused on the data management process and tested 5 expert queries in Hepatocarcinoma. RESULTS: the integration of biobank data was comprehensive and easy...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29677127/direct-hetero-arylation-polymerization-of-a-spirobifluorene-and-a-dithienyl-diketopyrrolopyrrole-derivative-new-donor-polymers-for-organic-solar-cells
#18
Pierre Josse, Sergey Dayneko, Yangqian Zhang, Sylvie Dabos-Seignon, Shiming Zhang, Philippe Blanchard, Gregory C Welch, Clément Cabanetos
The synthesis and preliminary evaluation as donor material for organic photovoltaics of the poly(diketopyrrolopyrrole-spirobifluorene) ( PDPPSBF ) is reported herein. Prepared via homogeneous and heterogeneous direct (hetero)arylation polymerization (DHAP), through the use of different catalytic systems, conjugated polymers with comparable molecular weights were obtained. The polymers exhibited strong optical absorption out to 700 nm as thin-films and had appropriate electronic energy levels for use as a donor with PC70 BM ...
April 20, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29675337/highly-diluted-acetylcholine-promotes-wound-repair-in-an-in-vivo-model
#19
Francesca Uberti, Vera Morsanuto, Sabrina Ghirlanda, Sara Ruga, Nausicaa Clemente, Cristina Boieri, Renzo Boldorini, Claudio Molinari
Objective: Wound healing is a dynamic, interactive, and complex process that involves a series of events, including inflammation, migration, proliferation, granulation tissue formation, and matrix remodeling. Despite the high frequency of serious slow-healing wounds, there is still no adequate therapy. The aim of this study is to evaluate a new highly diluted acetylcholine (Ach) formulation obtained through a sequential kinetic activation (SKA) method applied to a wound healing in vivo model to verify the hypothesis that a low dose of Ach could be a more physiological stimulus for healing, by stimulating muscarinic and nicotinic receptors and their related intracellular pathways...
April 1, 2018: Advances in Wound Care
https://www.readbyqxmd.com/read/29674164/impact-of-r152k-and-r368k-neuraminidase-catalytic-substitutions-on-in-vitro-properties-and-virulence-of-recombinant-a-h1n1-pdm09-viruses
#20
Véronique Tu, Yacine Abed, Clément Fage, Mariana Baz, Guy Boivin
Neuraminidase (NA) mutations conferring resistance to NA inhibitors (NAIs) are expected to occur at framework or catalytic residues of the NA enzyme. Numerous clinical and in vitro reports already described NAI-resistant A(H1N1)pdm09 variants harboring various framework NA substitutions. By contrast, variants with NA catalytic changes remain poorly documented. Herein, we investigated the effect of R152K and R368K NA catalytic mutations on the NA enzyme properties, in vitro replicative capacity and virulence of A(H1N1)pdm09 recombinant viruses...
April 16, 2018: Antiviral Research
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