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https://www.readbyqxmd.com/read/29039952/chloromonilinic-acids-c-and-d-phytotoxic-tetrasubstituted-3-chromanonacrylic-acids-isolated-from-cochliobolus-australiensis-with-potential-herbicidal-activity-against-buffelgrass-cenchrus-ciliaris
#1
Marco Masi, Susan Meyer, Suzette Clement, Gennaro Pescitelli, Alessio Cimmino, Massimo Cristofaro, Antonio Evidente
The fungal pathogen Cochliobolus australiensis isolated from infected leaves of the invasive weed buffelgrass (Pennisetum ciliare) was grown in vitro to evaluate its ability to produce phytotoxic metabolites that could potentially be used as natural herbicides against this weed. Two new tetrasubstituted 3-chromanonacrylic acids, named chloromonilinic acids C (1) and D (2), were isolated from the liquid cultures of C. australiensis, together with the known chloromonilinic acid B. Chloromonilinic acids C and D were characterized by spectroscopic and chemical methods as (E)-3-chloro-3-[(5-hydroxy-3-(1-hydroxy-2-methoxy-2-oxoethyl)-7-methyl-4-oxo-4H-chromen-2-yl)]acrylic acid and (Z)-3-chloro-3-[(5-hydroxy-3-(2-methoxy-2-oxoethyl)-7-methyl-4-oxo-4H-chromen-2-yl)]acrylic acid, respectively...
October 17, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/29036644/roles-of-female-and-male-genotype-in-post-mating-responses-in-drosophila-melanogaster-roles-of-female-and-male-genotype-in-female-drosophila-melanogaster-transcriptional-physiological-and-behavioral-responses-to-mating
#2
Sofie Y N Delbare, Clement Y Chow, Mariana F Wolfner, Andrew G Clark
Mating induces a multitude of changes in female behavior, physiology and gene expression. Interactions between female and male genotype lead to variation in post-mating phenotypes and reproductive success. So far, few female molecules responsible for these interactions have been identified. Here, we used Drosophila melanogaster from five geographically dispersed populations to investigate such female x male genotypic interactions at the female transcriptomic and phenotypic levels. Females from each line were singly-mated to males from the same five lines, for a total of 25 combinations...
October 4, 2017: Journal of Heredity
https://www.readbyqxmd.com/read/29035381/high-expression-of-hoxa13-correlates-with-poorly-differentiated-hepatocellular-carcinomas-and-modulates-sorafenib-response-in-in-vitro-models
#3
Luca Quagliata, Cristina Quintavalle, Manuela Lanzafame, Matthias S Matter, Chiara Novello, Luca di Tommaso, Tiziana Pressiani, Lorenza Rimassa, Luigi Tornillo, Massimo Roncalli, Clemente Cillo, Pierlorenzo Pallante, Salvatore Piscuoglio, Charlotte Ky Ng, Luigi M Terracciano
Hepatocellular carcinoma (HCC) represents the fifth and ninth cause of mortality among male and female cancer patients, respectively and typically arises on a background of a cirrhotic liver. HCC develops in a multi-step process, often encompassing chronic liver injury, steatosis and cirrhosis eventually leading to the malignant transformation of hepatocytes. Aberrant expression of the class I homeobox gene family (HOX), a group of genes crucial in embryogenesis, has been reported in a variety of malignancies including solid tumors...
October 16, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/29032585/infection-surveillance-in-pediatric-hematopoietic-stem-cell-transplantation-recipients
#4
Daniela Caldas Teixeira, Lilian Martins Oliveira Diniz, Paulo Henrique Orlandi Mourão, Fabiana Maria Kakehashi, Antonio Vaz de Macedo, Helena Duani, Wanessa Trindade Clemente, Karla Emília de Sá Rodrigues, Roberta Maia de Castro Romanelli
OBJECTIVE: Describe the profile of reported Healthcare-Associated Infections (HAIs) in pediatric patients submitted to hematopoietic stem cell transplantation (HSCT) at a reference center. METHODS: Retrospective cohort of pediatric patients who were submitted to HSCT from 2008 to 2016. The criteria for HAI were based on those established by the National Healthcare Safety Network. Data were collected by active surveillance performed daily by professionals. This study was approved by the Institutional Research Ethics Committee...
October 15, 2017: European Journal of Haematology
https://www.readbyqxmd.com/read/29031731/evaluation-of-a-melanocortin-4-receptor-mc4r-agonist-setmelanotide-in-mc4r-deficiency
#5
Tinh-Hai Collet, Béatrice Dubern, Jacek Mokrosinski, Hillori Connors, Julia M Keogh, Edson Mendes de Oliveira, Elana Henning, Christine Poitou-Bernert, Jean-Michel Oppert, Patrick Tounian, Florence Marchelli, Rohia Alili, Johanne Le Beyec, Dominique Pépin, Jean-Marc Lacorte, Andrew Gottesdiener, Rebecca Bounds, Shubh Sharma, Cathy Folster, Bart Henderson, Stephen O'Rahilly, Elizabeth Stoner, Keith Gottesdiener, Brandon L Panaro, Roger D Cone, Karine Clément, I Sadaf Farooqi, Lex H T Van der Ploeg
OBJECTIVE: Pro-opiomelanocortin (POMC)-derived peptides act on neurons expressing the Melanocortin 4 receptor (MC4R) to reduce body weight. Setmelanotide is a highly potent MC4R agonist that leads to weight loss in diet-induced obese animals and in obese individuals with complete POMC deficiency. While POMC deficiency is very rare, 1-5% of severely obese individuals harbor heterozygous mutations in MC4R. We sought to assess the efficacy of Setmelanotide in human MC4R deficiency. METHODS: We studied the effects of Setmelanotide on mutant MC4Rs in cells and the weight loss response to Setmelanotide administration in rodent studies and a human clinical trial...
October 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/29031595/unexpected-diagnosis-in-a-man-with-painful-and-swollen-leg
#6
Maria Giulia Tinti, Celeste Clemente, Graziella D'Amico, Michelangelo Nasuto, Vincenzo Carnevale
No abstract text is available yet for this article.
October 11, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/29031106/new-insights-into-resistance-to-colistin-and-third-generation-cephalosporins-of-escherichia-coli-in-poultry-portugal-novel-blactx-m-166-and-blaesac-genes
#7
Vera Manageiro, Lurdes Clemente, Rafael Graça, Ivone Correia, Teresa Albuquerque, Eugénia Ferreira, Manuela Caniça
The increasing incidence of intestinal colonization with extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae and Gram negative organisms that has been observed in food animals such as poultry, cattle and pigs, are suggestive that animals, food and environment are potential sources of ESBL-producing bacteria. Hence, the aim of this study was to characterized commensal E. coli obtained from healthy broiler and turkey flocks at slaughter for the presence of penicillinases-, ESBL-, extended-spectrum AmpC (ESAC)-, plasmid-mediated quinolone resistance- and MCR-encoding genes...
October 4, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29027185/advanced-containment-methods-for-legg-calv%C3%A3-perthes-disease-triple-pelvic-osteotomy-versus-chiari-osteotomy
#8
Olivier Rosello, Federico Solla, Ioana Oborocianu, Edouard Chau, Tony ElHayek, Jean-Luc Clement, Virginie Rampal
INTRODUCTION: The goal of intervention in Legg-Calvé-Perthes disease (LCPD) is to prevent femoral head deformation by containing the head within the acetabulum. Currently, surgical containment methods are the mainstay of treatment, and pelvic osteotomies have been shown to be successful. They include triple pelvic osteotomy (TPO), Salter osteotomy, Chiari osteotomy and shelf procedure. The purpose of this study was to compare clinical and radiologic results for Chiari osteotomy and TPO in LCPD...
October 11, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/29026879/tsunamis-in-the-geological-record-making-waves-with-a-cautionary-tale-from-the-mediterranean
#9
Nick Marriner, David Kaniewski, Christophe Morhange, Clément Flaux, Matthieu Giaime, Matteo Vacchi, James Goff
From 2000 to 2015, tsunamis and storms killed more than 430,000 people worldwide and affected a further >530 million, with total damages exceeding US$970 billion. These alarming trends, underscored by the tragic events of the 2004 Indian Ocean catastrophe, have fueled increased worldwide demands for assessments of past, present, and future coastal risks. Nonetheless, despite its importance for hazard mitigation, discriminating between storm and tsunami deposits in the geological record is one of the most challenging and hotly contended topics in coastal geoscience...
October 2017: Science Advances
https://www.readbyqxmd.com/read/29026132/evidence-of-early-stage-selection-on-epas1-and-gpr126-genes-in-andean-high-altitude-populations
#10
Christina A Eichstaedt, Luca Pagani, Tiago Antao, Charlotte E Inchley, Alexia Cardona, Alexander Mörseburg, Florian J Clemente, Timothy J Sluckin, Ene Metspalu, Mario Mitt, Reedik Mägi, Georgi Hudjashov, Mait Metspalu, Maru Mormina, Guy S Jacobs, Toomas Kivisild
The aim of this study is to identify genetic variants that harbour signatures of recent positive selection and may facilitate physiological adaptations to hypobaric hypoxia. To achieve this, we conducted whole genome sequencing and lung function tests in 19 Argentinean highlanders (>3500 m) comparing them to 16 Native American lowlanders. We developed a new statistical procedure using a combination of population branch statistics (PBS) and number of segregating sites by length (nSL) to detect beneficial alleles that arose since the settlement of the Andes and are currently present in 15-50% of the population...
October 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29025353/mass-spectrometry-based-proteomics-analyses-in-kallikrein-related-peptidase-research-implications-for-cancer-research-and-therapy
#11
Lakmali Munasinghage Silva, Judith Ann Clements
Kallikrein-related peptidases (KLKs) are a family of serine peptidases that are deregulated in numerous pathological conditions, with a multitude of KLK-mediated functional roles implicated in the progression of cancer. Advances in multidimensional mass spectrometry (MS)-based proteomics have facilitated the quantitative measurement of deregulated KLK expression in cancer, identifying certain KLKs, as well as their substrates, as potential cancer biomarkers. Areas covered: In this review, we discuss how these approaches have been utilized for KLK biomarker discovery and unbiased substrate determination in complex protein pools that mimic the in vivo extracellular microenvironment...
October 13, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/29025223/unusual-presentation-of-tinea-corporis-associated-with-the-use-of-a-microneedling-device
#12
Nélia Margarida Martins da Cunha, Sara Leite de Azevedo Campos, Ana Isabel Pina Clemente Fidalgo
No abstract text is available yet for this article.
July 1, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29025119/re-unit-conversions-between-loinc-codes-published-june-19-2017
#13
Daniel J Vreeman, Swapna Abhyankar, Clement J McDonald
No abstract text is available yet for this article.
August 23, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29024866/diclofenac-but-not-celecoxib-improves-endothelial-function-in-rheumatoid-arthritis-a-study-in-adjuvant-induced-arthritis
#14
Frank Verhoeven, Perle Totoson, Christine Marie, Anne Prigent-Tessier, Daniel Wendling, Maude Tournier-Nappey, Clément Prati, Céline Demougeot
BACKGROUND AND AIMS: We aimed at investigating the effect of celecoxib (COX-2 selective inhibitor) and diclofenac (non-selective COX inhibitor) on endothelial function, and at identifying the underlying mechanisms in adjuvant-induced arthritis (AIA). METHODS: At the first signs of AIA, diclofenac (5 mg/kg twice a day, i.p), celecoxib (3 mg/kg/day, i.p) or saline (Vehicle) was administered for 3 weeks. Endothelial function was studied in aortic rings relaxed with acetylcholine (Ach) with or without inhibitors of NOS, arginase, EDHF and superoxide anions (O2(-°)) production...
September 29, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29024428/heat-shock-protein-60-in-obesity-effect-of-bariatric-surgery-and-its-relation-to-inflammation-and-cardiovascular-risk
#15
Henrike Sell, Christine Poitou, Christiane Habich, Jean-Luc Bouillot, Jürgen Eckel, Karine Clément
OBJECTIVE: Heat shock protein 60 (Hsp60) is an adipokine, and its serum concentrations are higher in patients with obesity compared to lean patients. This study aimed to analyze the effect of bariatric surgery on circulating concentrations of Hsp60 in morbid obesity and their correlation with inflammation and metabolic and cardiovascular risk. METHODS: Fifty-three females with morbid obesity undergoing bariatric surgery were enrolled. Serum parameters and anthropometric measures were obtained at baseline and 3 to 12 months post surgery...
October 11, 2017: Obesity
https://www.readbyqxmd.com/read/29023752/a-novel-r3-myb-transcriptional-repressor-associated-with-the-loss-of-floral-pigmentation-in-iochroma
#16
Daniel J Gates, Bradley J S C Olson, Tom E Clemente, Stacey D Smith
Losses of floral pigmentation represent one of the most common evolutionary transitions in flower color, yet the genetic basis for these changes has been elucidated in only a handful of cases. Here we used crossing studies, bulk-segregant RNA sequencing, phylogenetic analyses and functional tests to identify the gene(s) responsible for the transition to white flowers in Iochroma loxense. Crosses between I. loxense and its blue-flowered sister species, I. cyaneum, suggested that a single locus controls the flower color difference and that the white allele causes a nearly complete loss of pigmentation...
October 12, 2017: New Phytologist
https://www.readbyqxmd.com/read/29022015/silylation-of-o-h-bonds-by-catalytic-dehydrogenative-and-decarboxylative-coupling-of-alcohols-with-silyl-formates
#17
Clément Chauvier, Timothé Godou, Thibault Cantat
The silylation of O-H bonds is a useful methodology in organic synthesis and materials science. While this transformation is commonly achieved by reacting alcohols with reactive chlorosilanes or hydrosilanes, we show herein for the first time that silylformates HCO2SiR3 are efficient silylating agents for alcohols, in the presence of a ruthenium molecular catalyst.
October 12, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29021945/an-evaluation-of-instructive-feedback-to-teach-play-behavior-to-a-child-with-autism-spectrum-disorder
#18
Laura L Grow, Tiffany Kodak, Andrea Clements
Instructive feedback is used to expose learners to secondary targets during skill acquisition programs (Reichow & Wolery, in Journal of Applied Behavior Analysis, 44, 327-340, 2011; Werts, Wolery, Gast, & Holcombe, in Journal of Behavioral Education, 5, 55-75, 1995). Although unrelated feedback may have clinical utility in practice, very little research has evaluated unrelated instructive feedback, particularly for promoting play behavior (Colozzi, Ward, & Crotty, in Education and Training in Developmental Disabilities, 43, 226-248, 2008)...
September 2017: Behavior Analysis in Practice
https://www.readbyqxmd.com/read/29020389/cactus-aorta
#19
Amira Mahrouf, Gilles Soulat, David Lebeaux, Laurence Iserin, Clement Karsenty
No abstract text is available yet for this article.
September 12, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29020212/screening-veterans-for-syphilis-implementation-of-the-reverse-sequence-algorithm
#20
Meredith E Clement, Amr Hammouda, Lawrence P Park, Jason Maxwell, Erika Samoff, Arlene C Seña, Maria Joyce
We evaluated the syphilis reverse sequence algorithm (RSA) in a Veteran Affairs facility, finding 5.5% reactive Treponema pallidum enzyme immunoassay (EIA) tests. In a subset of EIA+/VDRL-/TP-PA+ cases, 48% were previously treated. Of veterans with unknown/no prior therapy, only 45% had documentation of subsequent treatment, suggesting suboptimal interpretation of RSA results.
August 2, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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